Graded attenuation of TCR Signaling elicits distinct autoimmune diseases by altering thymic T cell selection and regulatory T cell function

Journal of Immunology

Volumn 185, Issue 4, 2010, Pages 2295-2305

  Tanaka, Satoshi ^a   Maeda, Shinji ^a   Hashimoto, Motomu ^a   Fujimori, Chihiro ^a   Ito, Yoshinaga ^a   Teradaira, Shin ^a   Hirota, Keiji ^a   Yoshitomi, Hiroyuki ^a   Katakai, Tomoya ^b   Shimizu, Akira ^a   Nomura, Takashi ^a   Sakaguchi, Noriko ^a   Sakaguchi, Shimon ^a,b,c,d  

^a KYOTO UNIVERSITY   (Japan)

^b KYOTO UNIVERSITY   (Japan)

^c JAPAN SCIENCE AND TECHNOLOGY AGENCY   (Japan)

^d OSAKA UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

PROTEIN KINASE ZAP 70; T LYMPHOCYTE RECEPTOR; TRANSCRIPTION FACTOR FOXP3; TYROSINE; LYMPHOCYTE ANTIGEN RECEPTOR;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTHRITIS; ARTICLE; ATTENUATION; AUTOIMMUNE DISEASE; CELL FUNCTION; CELL SELECTION; CELL STIMULATION; CELL TRANSFER; CELLULAR IMMUNITY; CONTROLLED STUDY; DISEASE COURSE; DISEASE SEVERITY; ENVIRONMENTAL EXPOSURE; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; GASTRITIS; GENE DOSAGE; GENE MUTATION; GENETIC ASSOCIATION; HISTOPATHOLOGY; INNATE IMMUNITY; MALE; MOUSE; NEWBORN; NONHUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; REGULATORY T LYMPHOCYTE; SIGNAL TRANSDUCTION; T CELL DEPLETION; THYMOCYTE; ANIMAL; BAGG ALBINO MOUSE; CYTOLOGY; FLOW CYTOMETRY; GENETICS; GENOTYPE; IMMUNOLOGY; INSULIN DEPENDENT DIABETES MELLITUS; METABOLISM; MOUSE MUTANT; NONOBESE DIABETIC MOUSE; NUDE MOUSE; T LYMPHOCYTE; THYMUS; TRANSGENIC MOUSE;

ANIMALS; ARTHRITIS; AUTOIMMUNE DISEASES; DIABETES MELLITUS, TYPE 1; FLOW CYTOMETRY; GENOTYPE; MICE; MICE, INBRED BALB C; MICE, INBRED NOD; MICE, KNOCKOUT; MICE, NUDE; MICE, TRANSGENIC; RECEPTORS, ANTIGEN, T-CELL; SIGNAL TRANSDUCTION; T-LYMPHOCYTES; T-LYMPHOCYTES, REGULATORY; THYMUS GLAND; ZAP-70 PROTEIN-TYROSINE KINASE;

EID: 77956894327     PISSN: 00221767     EISSN: 15506606     Source Type: Journal    
DOI: 10.4049/jimmunol.1000848     Document Type: Article

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