메뉴 건너뛰기




Volumn 40_41, Issue , 2016, Pages 82-99

Dietary phytochemicals as epigenetic modifiers in cancer: Promise and challenges

Author keywords

Cancer chemoprevention; Dietary agents; DNA methylation; Epigenetics; Histone modification; microRNA; Plant polyphenols

Indexed keywords

3 INDOLEMETHANOL; 3,3' DIINDOLYLMETHANE; APIGENIN; CURCUMIN; DNA; EPIGALLOCATECHIN GALLATE; GENISTEIN; ISOFLAVONE DERIVATIVE; LYCOPENE; ORGANOSULFUR DERIVATIVE; PHENETHYL ISOTHIOCYANATE; PLANT MEDICINAL PRODUCT; POLYPHENOL DERIVATIVE; QUERCETIN; RESVERATROL; SULFORAPHANE; UNTRANSLATED RNA; ANTINEOPLASTIC AGENT;

EID: 84975691111     PISSN: 1044579X     EISSN: 10963650     Source Type: Journal    
DOI: 10.1016/j.semcancer.2016.04.002     Document Type: Review
Times cited : (123)

References (258)
  • 1
    • 0031201685 scopus 로고    scopus 로고
    • Exploring and explaining epigenetic effects
    • [1] Henikoff, S., Matzke, M.A., Exploring and explaining epigenetic effects. Trends Genet. 13 (1997), 293–295.
    • (1997) Trends Genet. , vol.13 , pp. 293-295
    • Henikoff, S.1    Matzke, M.A.2
  • 2
    • 84895893232 scopus 로고    scopus 로고
    • Epigenetics: the sins of the father
    • [2] Hughes, V., Epigenetics: the sins of the father. Nature 507 (2014), 22–24.
    • (2014) Nature , vol.507 , pp. 22-24
    • Hughes, V.1
  • 3
    • 58549109636 scopus 로고    scopus 로고
    • X chromosome dosage compensation: how mammals keep the balance
    • [3] Payer, B., Lee, J.T., X chromosome dosage compensation: how mammals keep the balance. Annu. Rev. Genet. 42 (2008), 733–772.
    • (2008) Annu. Rev. Genet. , vol.42 , pp. 733-772
    • Payer, B.1    Lee, J.T.2
  • 4
    • 38949212693 scopus 로고    scopus 로고
    • A novel CpG island set identifies tissue-specific methylation at developmental gene loci
    • [4] Illingworth, R., Kerr, A., DeSousa, D., Jørgensen, H., Ellis, P., Stalker, J., et al. A novel CpG island set identifies tissue-specific methylation at developmental gene loci. PLoS Biol., 6, 2008, e22.
    • (2008) PLoS Biol. , vol.6 , pp. e22
    • Illingworth, R.1    Kerr, A.2    DeSousa, D.3    Jørgensen, H.4    Ellis, P.5    Stalker, J.6
  • 5
    • 0027378582 scopus 로고
    • Role for DNA methylation in genomic imprinting
    • [5] Li, E., Beard, C., Jaenisch, R., Role for DNA methylation in genomic imprinting. Nature 366 (1993), 362–365.
    • (1993) Nature , vol.366 , pp. 362-365
    • Li, E.1    Beard, C.2    Jaenisch, R.3
  • 6
    • 0035839057 scopus 로고    scopus 로고
    • The role of DNA methylation in mammalian epigenetics
    • [6] Jones, P.A., Takai, D., The role of DNA methylation in mammalian epigenetics. Science 293 (2001), 1068–1070.
    • (2001) Science , vol.293 , pp. 1068-1070
    • Jones, P.A.1    Takai, D.2
  • 7
    • 84888190386 scopus 로고    scopus 로고
    • Histone lysine methylation: critical regulator of memory and behavior
    • [7] Jarome, T.J., Lubin, F.D., Histone lysine methylation: critical regulator of memory and behavior. Rev. Neurosci. 24 (2013), 375–387.
    • (2013) Rev. Neurosci. , vol.24 , pp. 375-387
    • Jarome, T.J.1    Lubin, F.D.2
  • 8
    • 84984929135 scopus 로고    scopus 로고
    • The role of histone acetylation in memory formation and cognitive impairments
    • [8] Peixoto, L., Abel, T., The role of histone acetylation in memory formation and cognitive impairments. Neuropsychopharmacology 38 (2013), 62–76.
    • (2013) Neuropsychopharmacology , vol.38 , pp. 62-76
    • Peixoto, L.1    Abel, T.2
  • 9
    • 80052465880 scopus 로고    scopus 로고
    • Epigenetic mechanisms: critical contributors to long-term memory formation
    • [9] Lubin, F.D., Gupta, S., Parrish, R.R., Grissom, N.M., Davis, R.L., Epigenetic mechanisms: critical contributors to long-term memory formation. Neuroscientist 17 (2011), 616–632.
    • (2011) Neuroscientist , vol.17 , pp. 616-632
    • Lubin, F.D.1    Gupta, S.2    Parrish, R.R.3    Grissom, N.M.4    Davis, R.L.5
  • 10
    • 84878406298 scopus 로고    scopus 로고
    • Epigenetic mechanisms of gene expression regulation in neurological diseases
    • [10] Gos, M., Epigenetic mechanisms of gene expression regulation in neurological diseases. Acta Neurobiol. Exp. (Wars) 73 (2013), 19–37.
    • (2013) Acta Neurobiol. Exp. (Wars) , vol.73 , pp. 19-37
    • Gos, M.1
  • 11
    • 0036274359 scopus 로고    scopus 로고
    • The fundamental role of epigenetic events in cancer
    • [11] Jones, P.A., Baylin, S.B., The fundamental role of epigenetic events in cancer. Nat. Rev. Genet. 3 (2002), 415–428.
    • (2002) Nat. Rev. Genet. , vol.3 , pp. 415-428
    • Jones, P.A.1    Baylin, S.B.2
  • 12
    • 79958001269 scopus 로고    scopus 로고
    • The role of histone acetylation in age-associated memory impairment and Alzheimer's disease
    • [12] Stilling, R.M., Fischer, A., The role of histone acetylation in age-associated memory impairment and Alzheimer's disease. Neurobiol. Learn Mem. 96 (2011), 19–26.
    • (2011) Neurobiol. Learn Mem. , vol.96 , pp. 19-26
    • Stilling, R.M.1    Fischer, A.2
  • 13
    • 79954533286 scopus 로고    scopus 로고
    • Epigenetic priming of the metabolic syndrome
    • [13] Bruce, K.D., Cagampang, F.R., Epigenetic priming of the metabolic syndrome. Toxicol Mech Methods 21 (2011), 353–361.
    • (2011) Toxicol Mech Methods , vol.21 , pp. 353-361
    • Bruce, K.D.1    Cagampang, F.R.2
  • 14
    • 69349093211 scopus 로고    scopus 로고
    • Environmental influences on epigenetic profiles
    • [14] Suter, M.A., Aagaard-Tillery, K.M., Environmental influences on epigenetic profiles. Semin. Reprod. Med. 27 (2009), 380–390.
    • (2009) Semin. Reprod. Med. , vol.27 , pp. 380-390
    • Suter, M.A.1    Aagaard-Tillery, K.M.2
  • 15
    • 0037372003 scopus 로고    scopus 로고
    • Epigenetic regulation of gene expression: how the genome integrates intrinsic and environmental signals
    • [15] Jaenisch, R., Bird, A., Epigenetic regulation of gene expression: how the genome integrates intrinsic and environmental signals. Nat. Genet. 33 (2003), 245–254.
    • (2003) Nat. Genet. , vol.33 , pp. 245-254
    • Jaenisch, R.1    Bird, A.2
  • 16
    • 79954517272 scopus 로고    scopus 로고
    • From Waddington's epigenetic landscape to small noncoding RNA: some important milestones in the history of epigenetics research
    • [16] Choudhuri, S., From Waddington's epigenetic landscape to small noncoding RNA: some important milestones in the history of epigenetics research. Toxicol. Mech. Methods 21 (2011), 252–274.
    • (2011) Toxicol. Mech. Methods , vol.21 , pp. 252-274
    • Choudhuri, S.1
  • 17
  • 19
    • 78049429911 scopus 로고    scopus 로고
    • Cancer chemoprevention by dietary polyphenols: promising role for epigenetics
    • [19] Link, A., Balaguer, F., Goel, A., Cancer chemoprevention by dietary polyphenols: promising role for epigenetics. Biochem. Pharmacol. 80 (2010), 1771–1792.
    • (2010) Biochem. Pharmacol. , vol.80 , pp. 1771-1792
    • Link, A.1    Balaguer, F.2    Goel, A.3
  • 20
    • 84874459800 scopus 로고    scopus 로고
    • Cancer chemoprevention and nutriepigenetics: state of the art and future challenges
    • [20] Gerhauser, C., Cancer chemoprevention and nutriepigenetics: state of the art and future challenges. Top Curr. Chem. 329 (2013), 73–132.
    • (2013) Top Curr. Chem. , vol.329 , pp. 73-132
    • Gerhauser, C.1
  • 21
    • 0033753779 scopus 로고    scopus 로고
    • The DNA methyltransferases of mammals
    • [21] Bestor, T.H., The DNA methyltransferases of mammals. Hum. Mol. Genet. 9 (2000), 2395–2402.
    • (2000) Hum. Mol. Genet. , vol.9 , pp. 2395-2402
    • Bestor, T.H.1
  • 22
    • 0020582853 scopus 로고
    • On the mechanism of inhibition of DNA-cytosine methyltransferases by cytosine analogs
    • [22] Santi, D.V., Garrett, C.E., Barr, P.J., On the mechanism of inhibition of DNA-cytosine methyltransferases by cytosine analogs. Cell 33 (1983), 9–10.
    • (1983) Cell , vol.33 , pp. 9-10
    • Santi, D.V.1    Garrett, C.E.2    Barr, P.J.3
  • 23
    • 0036144048 scopus 로고    scopus 로고
    • DNA methylation patterns and epigenetic memory
    • [23] Bird, A., DNA methylation patterns and epigenetic memory. Genes Dev. 16 (2002), 6–21.
    • (2002) Genes Dev. , vol.16 , pp. 6-21
    • Bird, A.1
  • 24
    • 0031577334 scopus 로고    scopus 로고
    • DNA (cytosine-5)-methyltransferases in mouse cells and tissues: studies with a mechanism-based probe
    • [24] Yoder, J.A., Soman, N.S., Verdine, G.L., Bestor, T.H., DNA (cytosine-5)-methyltransferases in mouse cells and tissues: studies with a mechanism-based probe. J. Mol. Biol. 270 (1997), 385–395.
    • (1997) J. Mol. Biol. , vol.270 , pp. 385-395
    • Yoder, J.A.1    Soman, N.S.2    Verdine, G.L.3    Bestor, T.H.4
  • 25
    • 0033615717 scopus 로고    scopus 로고
    • DNA methyltransferases Dnmt3a and Dnmt3b are essential for de novo methylation and mammalian development
    • [25] Okano, M., Bell, D.W., Haber, D.A., Li, E., DNA methyltransferases Dnmt3a and Dnmt3b are essential for de novo methylation and mammalian development. Cell 99 (1999), 247–257.
    • (1999) Cell , vol.99 , pp. 247-257
    • Okano, M.1    Bell, D.W.2    Haber, D.A.3    Li, E.4
  • 26
    • 0035930660 scopus 로고    scopus 로고
    • Dnmt3L and the establishment of maternal genomic imprints
    • [26] Bourc'his, D., Xu, G.L., Lin, C.S., Bollman, B., Bestor, T.H., Dnmt3L and the establishment of maternal genomic imprints. Science 294 (2001), 2536–2539.
    • (2001) Science , vol.294 , pp. 2536-2539
    • Bourc'his, D.1    Xu, G.L.2    Lin, C.S.3    Bollman, B.4    Bestor, T.H.5
  • 27
    • 0036333103 scopus 로고    scopus 로고
    • Dnmt3L cooperates with the Dnmt3 family of de novo DNA methyltransferases to establish maternal imprints in mice
    • [27] Hata, K., Okano, M., Lei, H., Li, E., Dnmt3L cooperates with the Dnmt3 family of de novo DNA methyltransferases to establish maternal imprints in mice. Development 129 (2002), 1983–1993.
    • (2002) Development , vol.129 , pp. 1983-1993
    • Hata, K.1    Okano, M.2    Lei, H.3    Li, E.4
  • 28
    • 79959990071 scopus 로고    scopus 로고
    • Regulation of mammalian DNA methyltransferases: a route to new mechanisms
    • [28] Denis, H., Ndlovu, M.N., Fuks, F., Regulation of mammalian DNA methyltransferases: a route to new mechanisms. EMBO Rep. 12 (2011), 647–656.
    • (2011) EMBO Rep. , vol.12 , pp. 647-656
    • Denis, H.1    Ndlovu, M.N.2    Fuks, F.3
  • 29
    • 0024081657 scopus 로고
    • Cytosine methylation prevents binding to DNA of a HeLa cell transcription factor required for optimal expression of the adenovirus major late promoter
    • [29] Watt, F., Molloy, P.L., Cytosine methylation prevents binding to DNA of a HeLa cell transcription factor required for optimal expression of the adenovirus major late promoter. Genes Dev. 2 (1988), 1136–1143.
    • (1988) Genes Dev. , vol.2 , pp. 1136-1143
    • Watt, F.1    Molloy, P.L.2
  • 30
    • 0034713275 scopus 로고    scopus 로고
    • CTCF mediates methylation-sensitive enhancer-blocking activity at the H19/Igf2 locus
    • [30] Hark, A.T., Schoenherr, C.J., Katz, D.J., Ingram, R.S., Levorse, J.M., Tilghman, S.M., CTCF mediates methylation-sensitive enhancer-blocking activity at the H19/Igf2 locus. Nature 405 (2000), 486–489.
    • (2000) Nature , vol.405 , pp. 486-489
    • Hark, A.T.1    Schoenherr, C.J.2    Katz, D.J.3    Ingram, R.S.4    Levorse, J.M.5    Tilghman, S.M.6
  • 31
    • 0027535235 scopus 로고
    • Effects of DNA methylation on DNA-binding proteins and gene expression
    • [31] Tate, P.H., Bird, A.P., Effects of DNA methylation on DNA-binding proteins and gene expression. Curr. Opin. Genet Dev. 3 (1993), 226–231.
    • (1993) Curr. Opin. Genet Dev. , vol.3 , pp. 226-231
    • Tate, P.H.1    Bird, A.P.2
  • 32
    • 0031837109 scopus 로고    scopus 로고
    • Methylated DNA and MeCP2 recruit histone deacetylase to repress transcription
    • [32] Jones, P.L., Veenstra, G.J., Wade, P.A., Vermaak, D., Kass, S.U., Landsberger, N., et al. Methylated DNA and MeCP2 recruit histone deacetylase to repress transcription. Nat. Genet. 19 (1998), 187–191.
    • (1998) Nat. Genet. , vol.19 , pp. 187-191
    • Jones, P.L.1    Veenstra, G.J.2    Wade, P.A.3    Vermaak, D.4    Kass, S.U.5    Landsberger, N.6
  • 33
    • 0032574977 scopus 로고    scopus 로고
    • Transcriptional repression by the methyl-CpG-binding protein MeCP2 involves a histone deacetylase complex
    • [33] Nan, X., Ng, H.H., Johnson, C.A., Laherty, C.D., Turner, B.M., Eisenman, R.N., et al. Transcriptional repression by the methyl-CpG-binding protein MeCP2 involves a histone deacetylase complex. Nature 393 (1998), 386–389.
    • (1998) Nature , vol.393 , pp. 386-389
    • Nan, X.1    Ng, H.H.2    Johnson, C.A.3    Laherty, C.D.4    Turner, B.M.5    Eisenman, R.N.6
  • 34
    • 0035312289 scopus 로고    scopus 로고
    • The MeCP1 complex represses transcription through preferential binding, remodeling, and deacetylating methylated nucleosomes
    • [34] Feng, Q., Zhang, Y., The MeCP1 complex represses transcription through preferential binding, remodeling, and deacetylating methylated nucleosomes. Genes Dev. 15 (2001), 827–832.
    • (2001) Genes Dev. , vol.15 , pp. 827-832
    • Feng, Q.1    Zhang, Y.2
  • 35
    • 0031792779 scopus 로고    scopus 로고
    • Identification and characterization of a family of mammalian methyl-CpG binding proteins
    • [35] Hendrich, B., Bird, A., Identification and characterization of a family of mammalian methyl-CpG binding proteins. Mol. Cell. Biol. 18 (1998), 6538–6547.
    • (1998) Mol. Cell. Biol. , vol.18 , pp. 6538-6547
    • Hendrich, B.1    Bird, A.2
  • 36
    • 0027495467 scopus 로고
    • Dissection of the methyl-CpG binding domain from the chromosomal protein MeCP2
    • [36] Nan, X., Meehan, R.R., Bird, A., Dissection of the methyl-CpG binding domain from the chromosomal protein MeCP2. Nucliic Acids Res. 21 (1993), 4886–4892.
    • (1993) Nucliic Acids Res. , vol.21 , pp. 4886-4892
    • Nan, X.1    Meehan, R.R.2    Bird, A.3
  • 37
    • 85001875348 scopus 로고    scopus 로고
    • Integrative DNA methylome analysis of pan-cancer biomarkers in cancer discordant monozygotic twin-pairs
    • [37] Roos, L., Van Dongen, J., Bell, C.G., Burri, A., Deloukas, P., Boomsma, D.I., et al. Integrative DNA methylome analysis of pan-cancer biomarkers in cancer discordant monozygotic twin-pairs. Clin. Epigenetics., 8, 2016, 7.
    • (2016) Clin. Epigenetics. , vol.8 , pp. 7
    • Roos, L.1    Van Dongen, J.2    Bell, C.G.3    Burri, A.4    Deloukas, P.5    Boomsma, D.I.6
  • 38
    • 84953449456 scopus 로고    scopus 로고
    • Biological implications and therapeutic significance of DNA methylation regulated genes in cervical cancer
    • [38] Bhat, S., Kabekkodu, S.P., Noronha, A., Satyamoorthy, K., Biological implications and therapeutic significance of DNA methylation regulated genes in cervical cancer. Biochimie 121 (2016), 298–311.
    • (2016) Biochimie , vol.121 , pp. 298-311
    • Bhat, S.1    Kabekkodu, S.P.2    Noronha, A.3    Satyamoorthy, K.4
  • 39
    • 84958627366 scopus 로고    scopus 로고
    • DNA methylation, histone acetylation and methylation of epigenetic modifications as a therapeutic approach for cancers
    • [39] Yen, C.Y., Huang, H.W., Shu, C.W., Hou, M.F., Yuan, S.F., Wang, H.R., et al. DNA methylation, histone acetylation and methylation of epigenetic modifications as a therapeutic approach for cancers. Cancer Lett. 373 (2016), 185–192.
    • (2016) Cancer Lett. , vol.373 , pp. 185-192
    • Yen, C.Y.1    Huang, H.W.2    Shu, C.W.3    Hou, M.F.4    Yuan, S.F.5    Wang, H.R.6
  • 40
    • 0032055025 scopus 로고    scopus 로고
    • The histone tails of the nucleosome
    • [40] Luger, K., Richmond, T.J., The histone tails of the nucleosome. Curr. Opin Genet Dev. 8 (1998), 140–146.
    • (1998) Curr. Opin Genet Dev. , vol.8 , pp. 140-146
    • Luger, K.1    Richmond, T.J.2
  • 41
    • 0033529565 scopus 로고    scopus 로고
    • Twenty-five years of the nucleosome, fundamental particle of the eukaryote chromosome
    • [41] Kornberg, R.D., Lorch, Y., Twenty-five years of the nucleosome, fundamental particle of the eukaryote chromosome. Cell 98 (1999), 285–294.
    • (1999) Cell , vol.98 , pp. 285-294
    • Kornberg, R.D.1    Lorch, Y.2
  • 42
    • 0034610814 scopus 로고    scopus 로고
    • The language of covalent histone modifications
    • [42] Strahl, B.D., Allis, C.D., The language of covalent histone modifications. Nature 403 (2000), 41–45.
    • (2000) Nature , vol.403 , pp. 41-45
    • Strahl, B.D.1    Allis, C.D.2
  • 43
    • 0032030770 scopus 로고    scopus 로고
    • Histone acetylation and transcriptional regulatory mechanisms
    • [43] Struhl, K., Histone acetylation and transcriptional regulatory mechanisms. Genes Dev. 12 (1998), 599–606.
    • (1998) Genes Dev. , vol.12 , pp. 599-606
    • Struhl, K.1
  • 44
    • 79952534189 scopus 로고    scopus 로고
    • Regulation of chromatin by histone modifications
    • [44] Bannister, A.J., Kouzarides, T., Regulation of chromatin by histone modifications. Cell Res. 21 (2011), 381–395.
    • (2011) Cell Res. , vol.21 , pp. 381-395
    • Bannister, A.J.1    Kouzarides, T.2
  • 45
    • 0032142918 scopus 로고    scopus 로고
    • Roles of histone acetyltransferases and deacetylases in gene regulation
    • [45] Kuo, M.H., Allis, C.D., Roles of histone acetyltransferases and deacetylases in gene regulation. Bioessays 20 (1998), 615–626.
    • (1998) Bioessays , vol.20 , pp. 615-626
    • Kuo, M.H.1    Allis, C.D.2
  • 47
    • 41149141516 scopus 로고    scopus 로고
    • Histone deacetylases: target enzymes for cancer therapy
    • [47] Mottet, D., Castronovo, V., Histone deacetylases: target enzymes for cancer therapy. Clin. Exp. Metastasis 25 (2008), 183–189.
    • (2008) Clin. Exp. Metastasis , vol.25 , pp. 183-189
    • Mottet, D.1    Castronovo, V.2
  • 48
    • 35349006314 scopus 로고    scopus 로고
    • Histone lysine demethylases: emerging roles in development, physiology and disease
    • [48] Shi, Y., Histone lysine demethylases: emerging roles in development, physiology and disease. Nat. Rev. Genet. 8 (2007), 829–833.
    • (2007) Nat. Rev. Genet. , vol.8 , pp. 829-833
    • Shi, Y.1
  • 49
    • 0035370439 scopus 로고    scopus 로고
    • Histone methylation versus histone acetylation: new insights into epigenetic regulation
    • [49] Rice, J.C., Allis, C.D., Histone methylation versus histone acetylation: new insights into epigenetic regulation. Curr. Opin. Cell Biol. 13 (2001), 263–273.
    • (2001) Curr. Opin. Cell Biol. , vol.13 , pp. 263-273
    • Rice, J.C.1    Allis, C.D.2
  • 50
    • 79952112943 scopus 로고    scopus 로고
    • Dynamics of histone lysine methylation: structures of methyl writers and erasers
    • [50] Upadhyay, A.K., Cheng, X., Dynamics of histone lysine methylation: structures of methyl writers and erasers. Prog. Drug Res. 67 (2011), 107–124.
    • (2011) Prog. Drug Res. , vol.67 , pp. 107-124
    • Upadhyay, A.K.1    Cheng, X.2
  • 51
    • 84958282873 scopus 로고    scopus 로고
    • Circulating autoantibodies in cancer patients have high specificity for glycoxidation modified histone H2A
    • [51] Mir, A.R., Moinuddin Islam, S., Circulating autoantibodies in cancer patients have high specificity for glycoxidation modified histone H2A. Clin. Chim. Acta. 453 (2016), 48–55.
    • (2016) Clin. Chim. Acta. , vol.453 , pp. 48-55
    • Mir, A.R.1    Moinuddin Islam, S.2
  • 52
    • 84992197837 scopus 로고    scopus 로고
    • Histone modifying enzymes: novel disease biomarkers and assay development
    • [52] Ma, F., Zhang, C.Y., Histone modifying enzymes: novel disease biomarkers and assay development. Expert Rev. Mol. Diagn. 11 (2016), 1–10.
    • (2016) Expert Rev. Mol. Diagn. , vol.11 , pp. 1-10
    • Ma, F.1    Zhang, C.Y.2
  • 53
    • 84900414359 scopus 로고    scopus 로고
    • EZH2: not EZHY (Easy) to deal
    • [53] Deb, G., Singh, A.K., Gupta, S., EZH2: not EZHY (Easy) to deal. Mol. Cancer Res. 12 (2014), 639–653.
    • (2014) Mol. Cancer Res. , vol.12 , pp. 639-653
    • Deb, G.1    Singh, A.K.2    Gupta, S.3
  • 54
    • 33847076849 scopus 로고    scopus 로고
    • Chromatin modifications and their function
    • [54] Kouzarides, T., Chromatin modifications and their function. Cell 128 (2007), 693–705.
    • (2007) Cell , vol.128 , pp. 693-705
    • Kouzarides, T.1
  • 55
    • 33645987615 scopus 로고    scopus 로고
    • Epigenetic control using natural products and synthetic molecules
    • [55] Suzuki, T., Miyata, N., Epigenetic control using natural products and synthetic molecules. Curr. Med. Chem. 13 (2006), 935–958.
    • (2006) Curr. Med. Chem. , vol.13 , pp. 935-958
    • Suzuki, T.1    Miyata, N.2
  • 56
    • 40649111338 scopus 로고    scopus 로고
    • Non-coding RNAs, epigenetics and complexity
    • [56] Costa, F.F., Non-coding RNAs, epigenetics and complexity. Gene 410 (2008), 9–17.
    • (2008) Gene , vol.410 , pp. 9-17
    • Costa, F.F.1
  • 57
    • 84891936130 scopus 로고    scopus 로고
    • Non-coding RNAs as direct and indirect modulators of epigenetic regulation
    • [57] Peschansky, V.J., Wahlestedt, C., Non-coding RNAs as direct and indirect modulators of epigenetic regulation. Epigenetics 9 (2014), 3–12.
    • (2014) Epigenetics , vol.9 , pp. 3-12
    • Peschansky, V.J.1    Wahlestedt, C.2
  • 58
    • 78649704843 scopus 로고    scopus 로고
    • Non-coding RNAs and their epigenetic regulatory mechanisms
    • [58] Zhou, H., Hu, H., Lai, M., Non-coding RNAs and their epigenetic regulatory mechanisms. Biol. Cell. 102 (2010), 645–655.
    • (2010) Biol. Cell. , vol.102 , pp. 645-655
    • Zhou, H.1    Hu, H.2    Lai, M.3
  • 59
    • 0035195942 scopus 로고    scopus 로고
    • Non-coding RNAs: the architects of eukaryotic complexity
    • [59] Mattick, J.S., Non-coding RNAs: the architects of eukaryotic complexity. EMBO Rep. 2 (2001), 986–991.
    • (2001) EMBO Rep. , vol.2 , pp. 986-991
    • Mattick, J.S.1
  • 61
    • 84877330098 scopus 로고    scopus 로고
    • Multifaceted role of EZH2 in breast and prostate tumorigenesis: epigenetics and beyond
    • [61] Deb, G., Thakur, V.S., Gupta, S., Multifaceted role of EZH2 in breast and prostate tumorigenesis: epigenetics and beyond. Epigenetics 8 (2013), 464–476.
    • (2013) Epigenetics , vol.8 , pp. 464-476
    • Deb, G.1    Thakur, V.S.2    Gupta, S.3
  • 62
    • 61349112251 scopus 로고    scopus 로고
    • MYC stimulates EZH2 expression by repression of its negative regulator miR-26a
    • [62] Sander, S., Bullinger, L., Klapproth, K., Fiedler, K., Kestler, H.A., Barth, T.F., et al. MYC stimulates EZH2 expression by repression of its negative regulator miR-26a. Blood 112 (2008), 4202–4212.
    • (2008) Blood , vol.112 , pp. 4202-4212
    • Sander, S.1    Bullinger, L.2    Klapproth, K.3    Fiedler, K.4    Kestler, H.A.5    Barth, T.F.6
  • 63
    • 58149239686 scopus 로고    scopus 로고
    • Genomic loss of microRNA-101 leads to overexpression of histone methyltransferase EZH2 in cancer
    • [63] Varambally, S., Cao, Q., Mani, R.S., Shankar, S., Wang, X., Ateeg, B., et al. Genomic loss of microRNA-101 leads to overexpression of histone methyltransferase EZH2 in cancer. Science 322 (2008), 1695–1699.
    • (2008) Science , vol.322 , pp. 1695-1699
    • Varambally, S.1    Cao, Q.2    Mani, R.S.3    Shankar, S.4    Wang, X.5    Ateeg, B.6
  • 64
    • 70349764482 scopus 로고    scopus 로고
    • Mir-214-dependent regulation of the polycomb protein Ezh2 in skeletal muscle and embryonic stem cells
    • [64] Juan, A.H., Kumar, R.M., Marx, J.G., Young, R.A., Sartorelli, V., Mir-214-dependent regulation of the polycomb protein Ezh2 in skeletal muscle and embryonic stem cells. Mol. Cell. 36 (2009), 61–74.
    • (2009) Mol. Cell. , vol.36 , pp. 61-74
    • Juan, A.H.1    Kumar, R.M.2    Marx, J.G.3    Young, R.A.4    Sartorelli, V.5
  • 65
    • 84868108584 scopus 로고    scopus 로고
    • miR-200c inhibits melanoma progression and drug resistance through down-regulation of BMI-1
    • [65] Liu, S., Tetzlaff, M.T., Cui, R., Xu, X., miR-200c inhibits melanoma progression and drug resistance through down-regulation of BMI-1. Am. J. Pathol. 181 (2012), 1823–1835.
    • (2012) Am. J. Pathol. , vol.181 , pp. 1823-1835
    • Liu, S.1    Tetzlaff, M.T.2    Cui, R.3    Xu, X.4
  • 66
    • 56449126945 scopus 로고    scopus 로고
    • Targeting of the Bmi-1 oncogene/stem cell renewal factor by microRNA-128 inhibits glioma proliferation and self-renewal
    • [66] Godlewski, J., Nowicki, M.O., Bronisz, A., Williams, S., Otsuki, A., Nuovo, G., et al. Targeting of the Bmi-1 oncogene/stem cell renewal factor by microRNA-128 inhibits glioma proliferation and self-renewal. Cancer Res. 68 (2008), 9125–9130.
    • (2008) Cancer Res. , vol.68 , pp. 9125-9130
    • Godlewski, J.1    Nowicki, M.O.2    Bronisz, A.3    Williams, S.4    Otsuki, A.5    Nuovo, G.6
  • 67
    • 84953351370 scopus 로고    scopus 로고
    • lncRNAs and microRNAs with a role in cancer development
    • [67] Liz, J., Esteller, M., lncRNAs and microRNAs with a role in cancer development. Biochim. Biophys. Acta 1859 (2016), 169–176.
    • (2016) Biochim. Biophys. Acta , vol.1859 , pp. 169-176
    • Liz, J.1    Esteller, M.2
  • 69
    • 73049110243 scopus 로고    scopus 로고
    • The EMT-activator ZEB1 promotes tumorigenicity by repressing stemness-inhibiting microRNAs
    • [69] Wellner, U., Schubert, J., Burk, U.C., Schmalhofer, O., Zhu, F., Sonntag, A., et al. The EMT-activator ZEB1 promotes tumorigenicity by repressing stemness-inhibiting microRNAs. Nat. Cell Biol. 11 (2009), 1487–1495.
    • (2009) Nat. Cell Biol. , vol.11 , pp. 1487-1495
    • Wellner, U.1    Schubert, J.2    Burk, U.C.3    Schmalhofer, O.4    Zhu, F.5    Sonntag, A.6
  • 70
    • 35649020283 scopus 로고    scopus 로고
    • MicroRNA-29 family reverts aberrant methylation in lung cancer by targeting DNA methyltransferases 3A and 3B
    • [70] Fabbri, M., Garzon, R., Cimmino, A., Liu, Z., Zanesi, N., Callegari, E., et al. MicroRNA-29 family reverts aberrant methylation in lung cancer by targeting DNA methyltransferases 3A and 3B. Proc. Natl. Acad. Sci. U. S. A. 104 (2007), 15805–15810.
    • (2007) Proc. Natl. Acad. Sci. U. S. A. , vol.104 , pp. 15805-15810
    • Fabbri, M.1    Garzon, R.2    Cimmino, A.3    Liu, Z.4    Zanesi, N.5    Callegari, E.6
  • 71
    • 67650588646 scopus 로고    scopus 로고
    • MicroRNA-29b induces global DNA hypomethylation and tumor suppressor gene reexpression in acute myeloid leukemia by targeting directly DNMT3A and 3B and indirectly DNMT1
    • [71] Garzon, R., Liu, S., Fabbri, M., Liu, Z., Heaphy, C.E., Callegari, E., et al. MicroRNA-29b induces global DNA hypomethylation and tumor suppressor gene reexpression in acute myeloid leukemia by targeting directly DNMT3A and 3B and indirectly DNMT1. Blood 113 (2009), 6411–6418.
    • (2009) Blood , vol.113 , pp. 6411-6418
    • Garzon, R.1    Liu, S.2    Fabbri, M.3    Liu, Z.4    Heaphy, C.E.5    Callegari, E.6
  • 72
    • 82055161827 scopus 로고    scopus 로고
    • Cancer chemoprevention by targeting the epigenome
    • [72] Huang, J., Plass, C., Gerhauser, C., Cancer chemoprevention by targeting the epigenome. Curr. Drug Targets. 12 (2011), 1925–1956.
    • (2011) Curr. Drug Targets. , vol.12 , pp. 1925-1956
    • Huang, J.1    Plass, C.2    Gerhauser, C.3
  • 74
    • 84893709504 scopus 로고    scopus 로고
    • Plant phytochemicals as epigenetic modulators: role in cancer chemoprevention
    • [74] Thakur, V.S., Deb, G., Babcook, M.A., Gupta, S., Plant phytochemicals as epigenetic modulators: role in cancer chemoprevention. AAPS J. 16 (2014), 151–163.
    • (2014) AAPS J. , vol.16 , pp. 151-163
    • Thakur, V.S.1    Deb, G.2    Babcook, M.A.3    Gupta, S.4
  • 75
    • 56249130451 scopus 로고    scopus 로고
    • Targeting epigenetic mechanisms: potential of natural products in cancer chemoprevention
    • [75] Hauser, A.T., Jung, M., Targeting epigenetic mechanisms: potential of natural products in cancer chemoprevention. Planta Med. 74 (2008), 1593–1601.
    • (2008) Planta Med. , vol.74 , pp. 1593-1601
    • Hauser, A.T.1    Jung, M.2
  • 76
    • 48349133693 scopus 로고    scopus 로고
    • Evidence for dietary regulation of microRNA expression in cancer cells
    • [76] Davis, C.D., Ross, S.A., Evidence for dietary regulation of microRNA expression in cancer cells. Nutr. Rev. 66 (2008), 477–482.
    • (2008) Nutr. Rev. , vol.66 , pp. 477-482
    • Davis, C.D.1    Ross, S.A.2
  • 77
    • 77953198124 scopus 로고    scopus 로고
    • Regulation of microRNAs by natural agents: an emerging field in chemoprevention and chemotherapy research
    • [77] Li, Y., Kong, D., Wang, Z., Sarkar, F.H., Regulation of microRNAs by natural agents: an emerging field in chemoprevention and chemotherapy research. Pharm. Res. 27 (2010), 1027–1041.
    • (2010) Pharm. Res. , vol.27 , pp. 1027-1041
    • Li, Y.1    Kong, D.2    Wang, Z.3    Sarkar, F.H.4
  • 78
    • 34248226610 scopus 로고    scopus 로고
    • Apigenin and cancer chemoprevention: progress, potential and promise (review)
    • [78] Patel, D., Shukla, S., Gupta, S., Apigenin and cancer chemoprevention: progress, potential and promise (review). Int. J. Oncol. 30 (2007), 233–245.
    • (2007) Int. J. Oncol. , vol.30 , pp. 233-245
    • Patel, D.1    Shukla, S.2    Gupta, S.3
  • 79
    • 0034807826 scopus 로고    scopus 로고
    • Dietary agents in cancer prevention: flavonoids and isoflavonoids
    • [79] Birt, D.F., Hendrich, S., Wang, W., Dietary agents in cancer prevention: flavonoids and isoflavonoids. Pharmacol. Ther. 90 (2001), 157–177.
    • (2001) Pharmacol. Ther. , vol.90 , pp. 157-177
    • Birt, D.F.1    Hendrich, S.2    Wang, W.3
  • 80
    • 0142166328 scopus 로고    scopus 로고
    • Cancer chemoprevention with dietary phytochemicals
    • [80] Surh, Y.J., Cancer chemoprevention with dietary phytochemicals. Nat. Rev. Cancer 3 (2003), 768–780.
    • (2003) Nat. Rev. Cancer , vol.3 , pp. 768-780
    • Surh, Y.J.1
  • 82
    • 0022739616 scopus 로고
    • Anti-mutagenesis and anti-promotion by apigenin, robinetin and indole-3-carbinol
    • [82] Birt, D.F., Walker, B., Tibbels, M.G., Bresnick, E., Anti-mutagenesis and anti-promotion by apigenin, robinetin and indole-3-carbinol. Carcinogenesis 7 (1986), 959–963.
    • (1986) Carcinogenesis , vol.7 , pp. 959-963
    • Birt, D.F.1    Walker, B.2    Tibbels, M.G.3    Bresnick, E.4
  • 83
    • 0025176844 scopus 로고
    • Inhibitory effect of apigenin, a plant flavonoid, on epidermal ornithine decarboxylase and skin tumor promotion in mice
    • [83] Wei, H., Tye, L., Bresnick, E., Birt, D.F., Inhibitory effect of apigenin, a plant flavonoid, on epidermal ornithine decarboxylase and skin tumor promotion in mice. Cancer Res. 50 (1990), 499–502.
    • (1990) Cancer Res. , vol.50 , pp. 499-502
    • Wei, H.1    Tye, L.2    Bresnick, E.3    Birt, D.F.4
  • 84
    • 84890034659 scopus 로고    scopus 로고
    • Effects of C-glycosylation on anti-diabetic, anti-Alzheimer's disease and anti-inflammatory potential of apigenin
    • [84] Choi, J.S., Islam, M.N., Ali, M.Y., Kim, E.J., Kim, Y.M., Jung, H.A., Effects of C-glycosylation on anti-diabetic, anti-Alzheimer's disease and anti-inflammatory potential of apigenin. Food Chem. Toxicol. 64 (2014), 27–33.
    • (2014) Food Chem. Toxicol. , vol.64 , pp. 27-33
    • Choi, J.S.1    Islam, M.N.2    Ali, M.Y.3    Kim, E.J.4    Kim, Y.M.5    Jung, H.A.6
  • 85
    • 33845969839 scopus 로고    scopus 로고
    • Dietary polyphenols may affect DNA methylation
    • [85] Fang, M., Chen, D., Yang, C.S., Dietary polyphenols may affect DNA methylation. J. Nutr. 137 (2007), 223s–228s.
    • (2007) J. Nutr. , vol.137 , pp. 223s-228s
    • Fang, M.1    Chen, D.2    Yang, C.S.3
  • 86
    • 84867745055 scopus 로고    scopus 로고
    • Plant flavone apigenin inhibits HDAC and remodels chromatin to induce growth arrest and apoptosis in human prostate cancer cells: in vitro and in vivo study
    • [86] Pandey, M., Kaur, P., Shukla, S., Abbas, A., Fu, P., Gupta, S., Plant flavone apigenin inhibits HDAC and remodels chromatin to induce growth arrest and apoptosis in human prostate cancer cells: in vitro and in vivo study. Mol. Carcinog. 51 (2012), 952–962.
    • (2012) Mol. Carcinog. , vol.51 , pp. 952-962
    • Pandey, M.1    Kaur, P.2    Shukla, S.3    Abbas, A.4    Fu, P.5    Gupta, S.6
  • 87
    • 84903640329 scopus 로고    scopus 로고
    • Apigenin reactivates Nrf2 anti-oxidative stress signaling in mouse skin epidermal JB6 P+ cells through epigenetics modifications
    • [87] Paredes-Gonzalez, X., Fuentes, F., Su, Z.Y., Kong, A.N., Apigenin reactivates Nrf2 anti-oxidative stress signaling in mouse skin epidermal JB6 P+ cells through epigenetics modifications. AAPS J. 16 (2014), 727–735.
    • (2014) AAPS J. , vol.16 , pp. 727-735
    • Paredes-Gonzalez, X.1    Fuentes, F.2    Su, Z.Y.3    Kong, A.N.4
  • 88
    • 84921535683 scopus 로고    scopus 로고
    • Curcumin a component of golden spice: from bedside to bench and back
    • [88] Prasad, S., Gupta, S.C., Tyagi, A.K., Aggarwal, B.B., Curcumin a component of golden spice: from bedside to bench and back. Biotechnol. Adv. 32 (2014), 1053–1064.
    • (2014) Biotechnol. Adv. , vol.32 , pp. 1053-1064
    • Prasad, S.1    Gupta, S.C.2    Tyagi, A.K.3    Aggarwal, B.B.4
  • 89
    • 77149179813 scopus 로고    scopus 로고
    • Curcumin as an anti-cancer agent: review of the gap between basic and clinical applications
    • [89] Bar-Sela, G., Epelbaum, R., Schaffer, M., Curcumin as an anti-cancer agent: review of the gap between basic and clinical applications. Curr. Med. Chem. 17 (2010), 190–197.
    • (2010) Curr. Med. Chem. , vol.17 , pp. 190-197
    • Bar-Sela, G.1    Epelbaum, R.2    Schaffer, M.3
  • 91
    • 79952025567 scopus 로고    scopus 로고
    • Curcumin-the paradigm of a multi-target natural compound with applications in cancer prevention and treatment
    • [91] Teiten, M.H., Eifes, S., Dicato, M., Diederich, M., Curcumin-the paradigm of a multi-target natural compound with applications in cancer prevention and treatment. Toxins (Basel) 2 (2010), 128–162.
    • (2010) Toxins (Basel) , vol.2 , pp. 128-162
    • Teiten, M.H.1    Eifes, S.2    Dicato, M.3    Diederich, M.4
  • 92
    • 78349269863 scopus 로고    scopus 로고
    • Development of curcumin as an epigenetic agent
    • [92] Fu, S., Kurzrock, R., Development of curcumin as an epigenetic agent. Cancer 116 (2010), 4670–4676.
    • (2010) Cancer , vol.116 , pp. 4670-4676
    • Fu, S.1    Kurzrock, R.2
  • 93
    • 79958002242 scopus 로고    scopus 로고
    • Natural products as DNA methyltransferase inhibitors: a computer-aided discovery approach
    • [93] Medina-Franco, J.L., Lopez-Vallejo, F., Kuck, D., Lyko, F., Natural products as DNA methyltransferase inhibitors: a computer-aided discovery approach. Mol. Divers 15 (2011), 293–304.
    • (2011) Mol. Divers , vol.15 , pp. 293-304
    • Medina-Franco, J.L.1    Lopez-Vallejo, F.2    Kuck, D.3    Lyko, F.4
  • 95
    • 67650078931 scopus 로고    scopus 로고
    • Molecular modifications on carboxylic acid derivatives as potent histone deacetylase inhibitors: activity and docking studies
    • [95] Bora-Tatar, G., Dayangac-Erden, D., Demir, A.S., Dalkara, S., Yelekçi, K., Erdem-Yurter, H., Molecular modifications on carboxylic acid derivatives as potent histone deacetylase inhibitors: activity and docking studies. Bioorg Med. Chem. 17 (2009), 5219–5228.
    • (2009) Bioorg Med. Chem. , vol.17 , pp. 5219-5228
    • Bora-Tatar, G.1    Dayangac-Erden, D.2    Demir, A.S.3    Dalkara, S.4    Yelekçi, K.5    Erdem-Yurter, H.6
  • 96
    • 18744403080 scopus 로고    scopus 로고
    • Curcumin a potent anti-tumor reagent, is a novel histone deacetylase inhibitor regulating B-NHL cell line Raji proliferation
    • [96] Liu, H.L., Chen, Y., Cui, G.H., Zhou, J.F., Curcumin a potent anti-tumor reagent, is a novel histone deacetylase inhibitor regulating B-NHL cell line Raji proliferation. Acta Pharmacol. Sin. 26 (2005), 603–609.
    • (2005) Acta Pharmacol. Sin. , vol.26 , pp. 603-609
    • Liu, H.L.1    Chen, Y.2    Cui, G.H.3    Zhou, J.F.4
  • 97
    • 36248957463 scopus 로고    scopus 로고
    • Curcumin, both histone deacetylase and p300/CBP-specific inhibitor, represses the activity of nuclear factor kappa B and Notch 1 in Raji cells
    • [97] Chen, Y., Shu, W., Chen, W., Wu, Q., Liu, H., Cui, G., Curcumin, both histone deacetylase and p300/CBP-specific inhibitor, represses the activity of nuclear factor kappa B and Notch 1 in Raji cells. Basic Clin. Pharmacol. Toxicol. 101 (2007), 427–433.
    • (2007) Basic Clin. Pharmacol. Toxicol. , vol.101 , pp. 427-433
    • Chen, Y.1    Shu, W.2    Chen, W.3    Wu, Q.4    Liu, H.5    Cui, G.6
  • 98
    • 70349311616 scopus 로고    scopus 로고
    • Histone acetyl transferases as emerging drug targets
    • [98] Dekker, F.J., Haisma, H.J., Histone acetyl transferases as emerging drug targets. Drug Discov. Today 14 (2009), 942–948.
    • (2009) Drug Discov. Today , vol.14 , pp. 942-948
    • Dekker, F.J.1    Haisma, H.J.2
  • 99
    • 33746127271 scopus 로고    scopus 로고
    • Curcumin is an inhibitor of p300 histone acetylatransferase
    • [99] Marcu, M.G., Jung, Y.J., Lee, S., Chung, E.J., Lee, M.J., Trepel, J., et al. Curcumin is an inhibitor of p300 histone acetylatransferase. Med. Chem. 2 (2006), 169–174.
    • (2006) Med. Chem. , vol.2 , pp. 169-174
    • Marcu, M.G.1    Jung, Y.J.2    Lee, S.3    Chung, E.J.4    Lee, M.J.5    Trepel, J.6
  • 100
    • 10944243759 scopus 로고    scopus 로고
    • Curcumin, a novel p300/CREB-binding protein-specific inhibitor of acetyltransferase, represses the acetylation of histone/nonhistone proteins and histone acetyltransferase-dependent chromatin transcription
    • [100] Balasubramanyam, K., Varier, R.A., Altaf, M., Swaminathan, V., Siddappa, N.B., Ranga, U., et al. Curcumin, a novel p300/CREB-binding protein-specific inhibitor of acetyltransferase, represses the acetylation of histone/nonhistone proteins and histone acetyltransferase-dependent chromatin transcription. J. Biol. Chem. 279 (2004), 51163–51171.
    • (2004) J. Biol. Chem. , vol.279 , pp. 51163-51171
    • Balasubramanyam, K.1    Varier, R.A.2    Altaf, M.3    Swaminathan, V.4    Siddappa, N.B.5    Ranga, U.6
  • 101
    • 84923864187 scopus 로고    scopus 로고
    • Curcumin inhibits anchorage-independent growth of HT29 human colon cancer cells by targeting epigenetic restoration of the tumor suppressor gene DLEC1
    • [101] Guo, Y., Shu, L., Zhang, C., Su, Z.Y., Kong, A.N., Curcumin inhibits anchorage-independent growth of HT29 human colon cancer cells by targeting epigenetic restoration of the tumor suppressor gene DLEC1. Biochem. Pharmacol. 9 (2015), 69–78.
    • (2015) Biochem. Pharmacol. , vol.9 , pp. 69-78
    • Guo, Y.1    Shu, L.2    Zhang, C.3    Su, Z.Y.4    Kong, A.N.5
  • 102
    • 84930726122 scopus 로고    scopus 로고
    • Curcumin-Mediated reversal of p15 gene promoter methylation: implication in anti-Neoplastic action against acute lymphoid leukaemia cell line
    • [102] Sharma, V., Jha, A.K., Kumar, A., Bhatnagar, A., Narayan, G., Kaur, J., Curcumin-Mediated reversal of p15 gene promoter methylation: implication in anti-Neoplastic action against acute lymphoid leukaemia cell line. Folia Biol. (Praha) 61 (2015), 81–89.
    • (2015) Folia Biol. (Praha) , vol.61 , pp. 81-89
    • Sharma, V.1    Jha, A.K.2    Kumar, A.3    Bhatnagar, A.4    Narayan, G.5    Kaur, J.6
  • 103
    • 41649090153 scopus 로고    scopus 로고
    • Curcumin (diferuloylmethane) alters the expression profiles of microRNAs in human pancreatic cancer cells
    • [103] Sun, M., Estrov, Z., Ji, Y., Coombes, K.R., Harris, D.H., Kurzrock, R., Curcumin (diferuloylmethane) alters the expression profiles of microRNAs in human pancreatic cancer cells. Mol. Cancer Ther. 7 (2008), 464–473.
    • (2008) Mol. Cancer Ther. , vol.7 , pp. 464-473
    • Sun, M.1    Estrov, Z.2    Ji, Y.3    Coombes, K.R.4    Harris, D.H.5    Kurzrock, R.6
  • 104
    • 77951745289 scopus 로고    scopus 로고
    • Gemcitabine sensitivity can be induced in pancreatic cancer cells through modulation of miR-200 and miR-21 expression by curcumin or its analogue CDF
    • [104] Ali, S., Ahmad, A., Banerjee, S., Padhye, S., Dominiak, K., Schaffert, J.M., et al. Gemcitabine sensitivity can be induced in pancreatic cancer cells through modulation of miR-200 and miR-21 expression by curcumin or its analogue CDF. Cancer Res. 70 (2010), 3606–3617.
    • (2010) Cancer Res. , vol.70 , pp. 3606-3617
    • Ali, S.1    Ahmad, A.2    Banerjee, S.3    Padhye, S.4    Dominiak, K.5    Schaffert, J.M.6
  • 105
    • 84938746275 scopus 로고    scopus 로고
    • Curcumin reactivates silenced tumor suppressor gene RARβ by reducing DNA methylation
    • [105] Jiang, A., Wang, X., Shan, X., Li, Y., Wang, P., Jiang, P., Feng, Q., Curcumin reactivates silenced tumor suppressor gene RARβ by reducing DNA methylation. Phytother. Res. 29 (2015), 1237–1245.
    • (2015) Phytother. Res. , vol.29 , pp. 1237-1245
    • Jiang, A.1    Wang, X.2    Shan, X.3    Li, Y.4    Wang, P.5    Jiang, P.6    Feng, Q.7
  • 106
    • 84939176791 scopus 로고    scopus 로고
    • Dendrosomal curcumin increases expression of the long non coding RNA gene MEG3 via up-regulation of epi-miRs in hepatocellular cancer
    • [106] Zamani, M., Sadeghizadeh, M., Behmanesh, M., Najafi, F., Dendrosomal curcumin increases expression of the long non coding RNA gene MEG3 via up-regulation of epi-miRs in hepatocellular cancer. Phytomedicine 22 (2015), 961–967.
    • (2015) Phytomedicine , vol.22 , pp. 961-967
    • Zamani, M.1    Sadeghizadeh, M.2    Behmanesh, M.3    Najafi, F.4
  • 107
    • 66149149841 scopus 로고    scopus 로고
    • Green tea: nature's defense against malignancies
    • [107] Butt, M.S., Sultan, M.T., Green tea: nature's defense against malignancies. Crit. Rev. Food Sci. Nutr. 49 (2009), 463–473.
    • (2009) Crit. Rev. Food Sci. Nutr. , vol.49 , pp. 463-473
    • Butt, M.S.1    Sultan, M.T.2
  • 108
    • 34547680062 scopus 로고    scopus 로고
    • Green tea polyphenols: biology and therapeutic implications in cancer
    • [108] Shankar, S., Ganapathy, S., Srivastava, R.K., Green tea polyphenols: biology and therapeutic implications in cancer. Front. Biosci. 12 (2007), 4881–4899.
    • (2007) Front. Biosci. , vol.12 , pp. 4881-4899
    • Shankar, S.1    Ganapathy, S.2    Srivastava, R.K.3
  • 109
    • 0345275879 scopus 로고    scopus 로고
    • Tea polyphenol (−)-epigallocatechin-3-gallate inhibits DNA methyltransferase and reactivates methylation-silenced genes in cancer cell lines
    • [109] Fang, M.Z., Wang, Y., Ai, N., Hou, Z., Sun, Y., Lu, H., et al. Tea polyphenol (−)-epigallocatechin-3-gallate inhibits DNA methyltransferase and reactivates methylation-silenced genes in cancer cell lines. Cancer Res. 63 (2003), 7563–7570.
    • (2003) Cancer Res. , vol.63 , pp. 7563-7570
    • Fang, M.Z.1    Wang, Y.2    Ai, N.3    Hou, Z.4    Sun, Y.5    Lu, H.6
  • 110
    • 77951225012 scopus 로고    scopus 로고
    • Promoter demethylation and chromatin remodeling by green tea polyphenols leads to re-expression of GSTP1 in human prostate cancer cells
    • [110] Pandey, M., Shukla, S., Gupta, S., Promoter demethylation and chromatin remodeling by green tea polyphenols leads to re-expression of GSTP1 in human prostate cancer cells. Int. J. Cancer. 126 (2010), 2520–2533.
    • (2010) Int. J. Cancer. , vol.126 , pp. 2520-2533
    • Pandey, M.1    Shukla, S.2    Gupta, S.3
  • 111
    • 84863011392 scopus 로고    scopus 로고
    • Green tea polyphenols causes cell cycle arrest and apoptosis in prostate cancer cells by suppressing class I histone deacetylases
    • [111] Thakur, V.S., Gupta, K., Gupta, S., Green tea polyphenols causes cell cycle arrest and apoptosis in prostate cancer cells by suppressing class I histone deacetylases. Carcinogenesis 33 (2012), 377–784.
    • (2012) Carcinogenesis , vol.33 , pp. 377-784
    • Thakur, V.S.1    Gupta, K.2    Gupta, S.3
  • 112
    • 77957784810 scopus 로고    scopus 로고
    • Synergistic epigenetic reactivation of estrogen receptor-alpha (ERalpha) by combined green tea polyphenol and histone deacetylase inhibitor in ERalpha-negative breast cancer cells
    • [112] Li, Y., Yuan, Y.Y., Meeran, S.M., Tollefsbol, T.O., Synergistic epigenetic reactivation of estrogen receptor-alpha (ERalpha) by combined green tea polyphenol and histone deacetylase inhibitor in ERalpha-negative breast cancer cells. Mol. Cancer, 9, 2010, 274.
    • (2010) Mol. Cancer , vol.9 , pp. 274
    • Li, Y.1    Yuan, Y.Y.2    Meeran, S.M.3    Tollefsbol, T.O.4
  • 113
    • 79953692105 scopus 로고    scopus 로고
    • (−)-Epigallocatechin-3-gallate reactivates silenced tumor suppressor genes, Cip1/p21 and p16INK4a, by reducing DNA methylation and increasing histones acetylation in human skin cancer cells
    • [113] Nandakumar, V., Vaid, M., Katiyar, S.K., (−)-Epigallocatechin-3-gallate reactivates silenced tumor suppressor genes, Cip1/p21 and p16INK4a, by reducing DNA methylation and increasing histones acetylation in human skin cancer cells. Carcinogenesis 32 (2011), 537–544.
    • (2011) Carcinogenesis , vol.32 , pp. 537-544
    • Nandakumar, V.1    Vaid, M.2    Katiyar, S.K.3
  • 114
    • 77950907191 scopus 로고    scopus 로고
    • The Bmi-1 polycomb protein antagonizes the (−)-epigallocatechin-3-gallate-dependent suppression of skin cancer cell survival
    • [114] Balasubramanian, S., Adhikary, G., Eckert, R.L., The Bmi-1 polycomb protein antagonizes the (−)-epigallocatechin-3-gallate-dependent suppression of skin cancer cell survival. Carcinogenesis 31 (2010), 496–503.
    • (2010) Carcinogenesis , vol.31 , pp. 496-503
    • Balasubramanian, S.1    Adhikary, G.2    Eckert, R.L.3
  • 115
    • 80053139713 scopus 로고    scopus 로고
    • (−)-Epigallocatechin-3-gallate and DZNep reduce polycomb protein level via a proteasome-dependent mechanism in skin cancer cells
    • [115] Choudhury, S.R., Balasubramanian, S., Chew, Y.C., Han, B., Marquez, V.E., Eckert, R.L., (−)-Epigallocatechin-3-gallate and DZNep reduce polycomb protein level via a proteasome-dependent mechanism in skin cancer cells. Carcinogenesis 32 (2011), 1525–1532.
    • (2011) Carcinogenesis , vol.32 , pp. 1525-1532
    • Choudhury, S.R.1    Balasubramanian, S.2    Chew, Y.C.3    Han, B.4    Marquez, V.E.5    Eckert, R.L.6
  • 116
    • 84926992337 scopus 로고    scopus 로고
    • Epigenetic induction of tissue inhibitor of matrix metalloproteinase-3 by green tea polyphenols in breast cancer cells
    • [116] Deb, G., Thakur, V.S., Limaye, A.M., Gupta, S., Epigenetic induction of tissue inhibitor of matrix metalloproteinase-3 by green tea polyphenols in breast cancer cells. Mol. Carcinog. 54 (2014), 485–499.
    • (2014) Mol. Carcinog. , vol.54 , pp. 485-499
    • Deb, G.1    Thakur, V.S.2    Limaye, A.M.3    Gupta, S.4
  • 117
    • 84924873819 scopus 로고    scopus 로고
    • (−)-Epigallocatechin-3 gallate reverses the expression of various tumor suppressor genes by inhibiting DNA methyltransferases and histone deacetylases in human cervical cancer cells
    • [117] Khan, M.A., Hussain, A., Sundaram, M.K., Alalami, U., Gunasekera, D., Ramesh, L., et al. (−)-Epigallocatechin-3 gallate reverses the expression of various tumor suppressor genes by inhibiting DNA methyltransferases and histone deacetylases in human cervical cancer cells. Oncol. Rep. 33 (2015), 1976–1984.
    • (2015) Oncol. Rep. , vol.33 , pp. 1976-1984
    • Khan, M.A.1    Hussain, A.2    Sundaram, M.K.3    Alalami, U.4    Gunasekera, D.5    Ramesh, L.6
  • 118
    • 84940473355 scopus 로고    scopus 로고
    • Epigallocatechin-3-gallate inhibits the invasion of salivary adenoid cystic carcinoma cells by reversing the hypermethylation status of the RECK gene
    • [118] Zhou, X.Q., Xu, X.N., Li, L., Ma, J.J., Zhen, E.M., Han, C.B., Epigallocatechin-3-gallate inhibits the invasion of salivary adenoid cystic carcinoma cells by reversing the hypermethylation status of the RECK gene. Mol. Med. Rep. 12 (2015), 6031–6036.
    • (2015) Mol. Med. Rep. , vol.12 , pp. 6031-6036
    • Zhou, X.Q.1    Xu, X.N.2    Li, L.3    Ma, J.J.4    Zhen, E.M.5    Han, C.B.6
  • 119
    • 84942550446 scopus 로고    scopus 로고
    • Natural compounds DNA methyltransferase inhibitors in oral squamous cell carcinoma
    • [119] Jha, M., Aggarwal, R., Jha, A.K., Shrivastava, A., Natural compounds DNA methyltransferase inhibitors in oral squamous cell carcinoma. Appl. Biochem. Biotechnol. 177 (2015), 577–594.
    • (2015) Appl. Biochem. Biotechnol. , vol.177 , pp. 577-594
    • Jha, M.1    Aggarwal, R.2    Jha, A.K.3    Shrivastava, A.4
  • 120
    • 84940541392 scopus 로고    scopus 로고
    • A genome-wide study of DNA methylation modified by epigallocatechin-3-gallate in the CAL-27 cell line
    • [120] Chen, L.L., Han, W.F., Geng, Y., Su, J.S., A genome-wide study of DNA methylation modified by epigallocatechin-3-gallate in the CAL-27 cell line. Mol. Med. Rep. 12 (2015), 5886–5890.
    • (2015) Mol. Med. Rep. , vol.12 , pp. 5886-5890
    • Chen, L.L.1    Han, W.F.2    Geng, Y.3    Su, J.S.4
  • 121
    • 0027134712 scopus 로고
    • Genistein, daidzein, and their β-glycoside conjugates: antitumor isoflavones in soybean foods from American and Asian diets
    • [121] Coward, L., Barnes, N.C., Setchell, K.D.R., Barnes, S., Genistein, daidzein, and their β-glycoside conjugates: antitumor isoflavones in soybean foods from American and Asian diets. J. Agric. Food Chem. 41 (1993), 1961–1967.
    • (1993) J. Agric. Food Chem. , vol.41 , pp. 1961-1967
    • Coward, L.1    Barnes, N.C.2    Setchell, K.D.R.3    Barnes, S.4
  • 122
    • 0031089258 scopus 로고    scopus 로고
    • A comparative survey of leguminous plants as sources of the isoflavones, genistein and daidzein: implications for human nutrition and health
    • [122] Kaufman, P.B., Duke, J.A., Brielmann, H., Boik, J., Hoyt, J.E., A comparative survey of leguminous plants as sources of the isoflavones, genistein and daidzein: implications for human nutrition and health. J. Altern. Complement Med. 3 (1997), 7–12.
    • (1997) J. Altern. Complement Med. , vol.3 , pp. 7-12
    • Kaufman, P.B.1    Duke, J.A.2    Brielmann, H.3    Boik, J.4    Hoyt, J.E.5
  • 123
    • 48749117943 scopus 로고    scopus 로고
    • Multi-targeted therapy of cancer by genistein
    • [123] Banerjee, S., Li, Y., Wang, Z., Sarkar, F.H., Multi-targeted therapy of cancer by genistein. Cancer Lett. 269 (2008), 226–242.
    • (2008) Cancer Lett. , vol.269 , pp. 226-242
    • Banerjee, S.1    Li, Y.2    Wang, Z.3    Sarkar, F.H.4
  • 124
    • 26444451123 scopus 로고    scopus 로고
    • Reversal of hypermethylation and reactivation of p16INK4a, RARbeta, and MGMT genes by genistein and other isoflavones from soy
    • [124] Fang, M.Z., Chen, D., Sun, Y., Jin, Z., Christman, J.K., Yang, C.S., Reversal of hypermethylation and reactivation of p16INK4a, RARbeta, and MGMT genes by genistein and other isoflavones from soy. Clin. Cancer Res. 11 (2005), 7033–7041.
    • (2005) Clin. Cancer Res. , vol.11 , pp. 7033-7041
    • Fang, M.Z.1    Chen, D.2    Sun, Y.3    Jin, Z.4    Christman, J.K.5    Yang, C.S.6
  • 125
    • 67449084948 scopus 로고    scopus 로고
    • Genistein depletes telomerase activity through cross-talk between genetic and epigenetic mechanisms
    • [125] Li, Y., Liu, L., Andrews, L.G., Tollefsbol, T.O., Genistein depletes telomerase activity through cross-talk between genetic and epigenetic mechanisms. Int. J. Cancer 125 (2009), 286–296.
    • (2009) Int. J. Cancer , vol.125 , pp. 286-296
    • Li, Y.1    Liu, L.2    Andrews, L.G.3    Tollefsbol, T.O.4
  • 126
    • 39749140314 scopus 로고    scopus 로고
    • Modulation of gene methylation by genistein or lycopene in breast cancer cells
    • [126] King-Batoon, A., Leszczynska, J.M., Klein, C.B., Modulation of gene methylation by genistein or lycopene in breast cancer cells. Environ. Mol. Mutagen 49 (2008), 36–45.
    • (2008) Environ. Mol. Mutagen , vol.49 , pp. 36-45
    • King-Batoon, A.1    Leszczynska, J.M.2    Klein, C.B.3
  • 127
    • 64349112758 scopus 로고    scopus 로고
    • BTG3 tumor suppressor gene promoter demethylation, histone modification and cell cycle arrest by genistein in renal cancer
    • [127] Majid, S., Dar, A.A., Ahmad, A.E., Hirata, H., Kawakami, K., Shahryari, V., et al. BTG3 tumor suppressor gene promoter demethylation, histone modification and cell cycle arrest by genistein in renal cancer. Carcinogenesis 30 (2009), 662–670.
    • (2009) Carcinogenesis , vol.30 , pp. 662-670
    • Majid, S.1    Dar, A.A.2    Ahmad, A.E.3    Hirata, H.4    Kawakami, K.5    Shahryari, V.6
  • 128
    • 74549216395 scopus 로고    scopus 로고
    • Genistein reverses hypermethylation and induces active histone modifications in tumor suppressor gene B-Cell translocation gene 3 in prostate cancer
    • [128] Majid, S., Dar, A.A., Shahryari, V., Hirata, H., Ahmad, A., Saini, S., et al. Genistein reverses hypermethylation and induces active histone modifications in tumor suppressor gene B-Cell translocation gene 3 in prostate cancer. Cancer 116 (2010), 66–76.
    • (2010) Cancer , vol.116 , pp. 66-76
    • Majid, S.1    Dar, A.A.2    Shahryari, V.3    Hirata, H.4    Ahmad, A.5    Saini, S.6
  • 131
    • 42349103444 scopus 로고    scopus 로고
    • Genistein induces the p21WAF1/CIP1 and p16INK4a tumor suppressor genes in prostate cancer cells by epigenetic mechanisms involving active chromatin modification
    • [131] Majid, S., Kikuno, N., Nelles, J., Noonan, E., Tanaka, Y., Kawamoto, K., et al. Genistein induces the p21WAF1/CIP1 and p16INK4a tumor suppressor genes in prostate cancer cells by epigenetic mechanisms involving active chromatin modification. Cancer Res. 68 (2008), 2736–2744.
    • (2008) Cancer Res. , vol.68 , pp. 2736-2744
    • Majid, S.1    Kikuno, N.2    Nelles, J.3    Noonan, E.4    Tanaka, Y.5    Kawamoto, K.6
  • 132
    • 55749097776 scopus 로고    scopus 로고
    • Genistein down-regulates androgen receptor by modulating HDAC6-Hsp90 chaperone function
    • [132] Basak, S., Pookot, D., Noonan, E.J., Dahiya, R., Genistein down-regulates androgen receptor by modulating HDAC6-Hsp90 chaperone function. Mol. Cancer Ther. 7 (2008), 3195–3202.
    • (2008) Mol. Cancer Ther. , vol.7 , pp. 3195-3202
    • Basak, S.1    Pookot, D.2    Noonan, E.J.3    Dahiya, R.4
  • 133
    • 84926505813 scopus 로고    scopus 로고
    • Genome-wide DNA methylation modified by soy phytoestrogens: role for epigenetic therapeutics in prostate cancer?
    • [133] Karsli-Ceppioglu, S., Ngollo, M., Adjakly, M., Dagdemir, A., Judes, G., Lebert, A., et al. Genome-wide DNA methylation modified by soy phytoestrogens: role for epigenetic therapeutics in prostate cancer?. OMICS 19 (2015), 209–219.
    • (2015) OMICS , vol.19 , pp. 209-219
    • Karsli-Ceppioglu, S.1    Ngollo, M.2    Adjakly, M.3    Dagdemir, A.4    Judes, G.5    Lebert, A.6
  • 134
    • 84928818101 scopus 로고    scopus 로고
    • Genistein increases estrogen receptor beta expression in prostate cancer via reducing its promoter methylation
    • [134] Mahmoud, A.M., Al-Alem, U., Ali, M.M., Bosland, M.C., Genistein increases estrogen receptor beta expression in prostate cancer via reducing its promoter methylation. J. Steroid Biochem. Mol. Biol. 152 (2015), 62–75.
    • (2015) J. Steroid Biochem. Mol. Biol. , vol.152 , pp. 62-75
    • Mahmoud, A.M.1    Al-Alem, U.2    Ali, M.M.3    Bosland, M.C.4
  • 135
    • 61649113446 scopus 로고    scopus 로고
    • Soy isoflavones have an antiestrogenic effect and alter mammary promoter hypermethylation in healthy premenopausal women
    • [135] Qin, W., Zhu, W., Shi, H., Hewett, J.E., Ruhlen, R.L., MacDonald, R.S., et al. Soy isoflavones have an antiestrogenic effect and alter mammary promoter hypermethylation in healthy premenopausal women. Nutr. Cancer 61 (2009), 238–244.
    • (2009) Nutr. Cancer , vol.61 , pp. 238-244
    • Qin, W.1    Zhu, W.2    Shi, H.3    Hewett, J.E.4    Ruhlen, R.L.5    MacDonald, R.S.6
  • 137
    • 69249096109 scopus 로고    scopus 로고
    • Up-regulation of miR-200 and let-7 by natural agents leads to the reversal of epithelial-to-mesenchymal transition in gemcitabine-resistant pancreatic cancer cells
    • [137] Li, Y., VandenBoom, T.G., Kong, D., Wang, Z., Ali, S., Philip, P.A., et al. Up-regulation of miR-200 and let-7 by natural agents leads to the reversal of epithelial-to-mesenchymal transition in gemcitabine-resistant pancreatic cancer cells. Cancer Res. 69 (2009), 6704–6712.
    • (2009) Cancer Res. , vol.69 , pp. 6704-6712
    • Li, Y.1    VandenBoom, T.G.2    Kong, D.3    Wang, Z.4    Ali, S.5    Philip, P.A.6
  • 138
    • 70349316774 scopus 로고    scopus 로고
    • Genistein inhibits growth of human uveal melanoma cells and affects microRNA-27a and target gene expression
    • [138] Sun, Q., Cong, R., Yan, H., Gu, H., Zeng, Y., Liu, N., et al. Genistein inhibits growth of human uveal melanoma cells and affects microRNA-27a and target gene expression. Oncol. Rep. 22 (2009), 563–567.
    • (2009) Oncol. Rep. , vol.22 , pp. 563-567
    • Sun, Q.1    Cong, R.2    Yan, H.3    Gu, H.4    Zeng, Y.5    Liu, N.6
  • 139
    • 84927919829 scopus 로고    scopus 로고
    • Genistein inhibits human colorectal cancer growth and suppresses miR-95, Akt and SGK1
    • [139] Qin, J., Chen, J.X., Zhu, Z., Teng, J.A., Genistein inhibits human colorectal cancer growth and suppresses miR-95, Akt and SGK1. Cell Physiol. Biochem. 35 (2015), 2069–2077.
    • (2015) Cell Physiol. Biochem. , vol.35 , pp. 2069-2077
    • Qin, J.1    Chen, J.X.2    Zhu, Z.3    Teng, J.A.4
  • 141
    • 33645761199 scopus 로고    scopus 로고
    • The natural chemopreventive compound indole-3-carbinol: state of the science
    • [141] Rogan, E.G., The natural chemopreventive compound indole-3-carbinol: state of the science. In Vivo 20 (2006), 221–228.
    • (2006) In Vivo , vol.20 , pp. 221-228
    • Rogan, E.G.1
  • 142
    • 34547180025 scopus 로고    scopus 로고
    • A review of the clinical efficacy and safety of cruciferous vegetable phytochemicals
    • [142] Minich, D.M., Bland, J.S., A review of the clinical efficacy and safety of cruciferous vegetable phytochemicals. Nutr. Rev. 65 (2007), 259–267.
    • (2007) Nutr. Rev. , vol.65 , pp. 259-267
    • Minich, D.M.1    Bland, J.S.2
  • 143
    • 84870475843 scopus 로고    scopus 로고
    • Chemopreventive properties of indole-3-carbinol, diindolylmethane and other constituents of cardamom against carcinogenesis
    • [143] Acharya, A., Das, I., Singh, S., Saha, T., Chemopreventive properties of indole-3-carbinol, diindolylmethane and other constituents of cardamom against carcinogenesis. Recent Pat. Food Nutr. Agric. 2 (2010), 166–177.
    • (2010) Recent Pat. Food Nutr. Agric. , vol.2 , pp. 166-177
    • Acharya, A.1    Das, I.2    Singh, S.3    Saha, T.4
  • 144
    • 25444449603 scopus 로고    scopus 로고
    • Molecular targets and anticancer potential of indole-3-carbinol and its derivatives
    • [144] Aggarwal, B.B., Ichikawa, H., Molecular targets and anticancer potential of indole-3-carbinol and its derivatives. Cell Cycle 4 (2005), 1201–1215.
    • (2005) Cell Cycle , vol.4 , pp. 1201-1215
    • Aggarwal, B.B.1    Ichikawa, H.2
  • 145
    • 79961211147 scopus 로고    scopus 로고
    • Attenuation of multi-targeted proliferation-linked signaling by 3,3′-diindolylmethane (DIM): from bench to clinic
    • [145] Banerjee, S., Kong, D., Wang, Z., Bao, B., Hillman, G.G., Sarkar, F.H., Attenuation of multi-targeted proliferation-linked signaling by 3,3′-diindolylmethane (DIM): from bench to clinic. Mutat. Res. 728 (2011), 47–66.
    • (2011) Mutat. Res. , vol.728 , pp. 47-66
    • Banerjee, S.1    Kong, D.2    Wang, Z.3    Bao, B.4    Hillman, G.G.5    Sarkar, F.H.6
  • 146
    • 76549093815 scopus 로고    scopus 로고
    • Chemopreventive agent 3,3′-diindolylmethane selectively induces proteasomal degradation of class I histone deacetylases
    • [146] Li, Y., Li, X., Guo, B., Chemopreventive agent 3,3′-diindolylmethane selectively induces proteasomal degradation of class I histone deacetylases. Cancer Res. 70 (2010), 646–654.
    • (2010) Cancer Res. , vol.70 , pp. 646-654
    • Li, Y.1    Li, X.2    Guo, B.3
  • 147
    • 84865429801 scopus 로고    scopus 로고
    • 3,3′-Diindolylmethane, but not indole-3-carbinol, inhibits histone deacetylase activity in prostate cancer cells
    • [147] Beaver, L.M., Yu, T.W., Sokolowski, E.I., Williams, D.E., Dashwood, R.H., Ho, E., 3,3′-Diindolylmethane, but not indole-3-carbinol, inhibits histone deacetylase activity in prostate cancer cells. Toxicol. Appl. Pharmacol. 263 (2012), 345–351.
    • (2012) Toxicol. Appl. Pharmacol. , vol.263 , pp. 345-351
    • Beaver, L.M.1    Yu, T.W.2    Sokolowski, E.I.3    Williams, D.E.4    Dashwood, R.H.5    Ho, E.6
  • 148
    • 84889576330 scopus 로고    scopus 로고
    • Natural indoles, indole-3-carbinol and 3,3'diindolymethane, inhibit T cell activation by staphylococcal enterotoxin B through epigenetic regulation involving HDAC expression
    • [148] Busbee, P.B., Nagarkatti, M., Nagarkatti, P.S., Natural indoles, indole-3-carbinol and 3,3'diindolymethane, inhibit T cell activation by staphylococcal enterotoxin B through epigenetic regulation involving HDAC expression. Toxicol. Appl. Pharmacol. 274 (2014), 7–16.
    • (2014) Toxicol. Appl. Pharmacol. , vol.274 , pp. 7-16
    • Busbee, P.B.1    Nagarkatti, M.2    Nagarkatti, P.S.3
  • 149
    • 76749152907 scopus 로고    scopus 로고
    • miR-146a suppresses invasion of pancreatic cancer cells
    • [149] Li, Y., Vandenboom, T.G., Wang, Z., Kong, D., Ali, S., Philip, P.A., et al. miR-146a suppresses invasion of pancreatic cancer cells. Cancer Res. 70 (2010), 1486–1495.
    • (2010) Cancer Res. , vol.70 , pp. 1486-1495
    • Li, Y.1    Vandenboom, T.G.2    Wang, Z.3    Kong, D.4    Ali, S.5    Philip, P.A.6
  • 150
    • 77956408743 scopus 로고    scopus 로고
    • 3,3′-Diindolylmethane negatively regulates Cdc25A and induces a G2/M arrest by modulation of microRNA 21 in human breast cancer cells
    • [150] Jin, Y., Zou, X., Feng, X., 3,3′-Diindolylmethane negatively regulates Cdc25A and induces a G2/M arrest by modulation of microRNA 21 in human breast cancer cells. Anticancer Drugs 21 (2010), 814–822.
    • (2010) Anticancer Drugs , vol.21 , pp. 814-822
    • Jin, Y.1    Zou, X.2    Feng, X.3
  • 151
    • 84929400940 scopus 로고    scopus 로고
    • DATS suppresses growth of esophageal squamous cell carcinoma by regulation of ERK1/2
    • [151] Wang, F., Li, S., Wang, L., Zong, H., Fan, Q., DATS suppresses growth of esophageal squamous cell carcinoma by regulation of ERK1/2. Clin. Lab. 61 (2015), 315–322.
    • (2015) Clin. Lab. , vol.61 , pp. 315-322
    • Wang, F.1    Li, S.2    Wang, L.3    Zong, H.4    Fan, Q.5
  • 152
    • 33847399068 scopus 로고    scopus 로고
    • Expression profiling by whole-genome microarray hybridization reveals differential gene expression in breast cancer cell lines after lycopene exposure
    • [152] Chalabi, N., Satih, S., Delort, L., Bignon, Y.J., Bernard-Gallon, D.J., Expression profiling by whole-genome microarray hybridization reveals differential gene expression in breast cancer cell lines after lycopene exposure. Biochim. Biophys. Acta 1769 (2007), 124–130.
    • (2007) Biochim. Biophys. Acta , vol.1769 , pp. 124-130
    • Chalabi, N.1    Satih, S.2    Delort, L.3    Bignon, Y.J.4    Bernard-Gallon, D.J.5
  • 154
    • 84911445517 scopus 로고    scopus 로고
    • The effects of lycopene on the methylation of the GSTP1 promoter and global methylation in prostatic cancer cell lines PC3 and LNCaP
    • [154] Fu, L.J., Ding, Y.B., Wu, L.X., Wen, C.J., Qu, Q., Zhang, X., et al. The effects of lycopene on the methylation of the GSTP1 promoter and global methylation in prostatic cancer cell lines PC3 and LNCaP. Int. J. Endocrinol., 2014, 2014, 620165.
    • (2014) Int. J. Endocrinol. , vol.2014 , pp. 620165
    • Fu, L.J.1    Ding, Y.B.2    Wu, L.X.3    Wen, C.J.4    Qu, Q.5    Zhang, X.6
  • 155
    • 63049130448 scopus 로고    scopus 로고
    • Biological properties of garlic and garlic-derived organosulfur compounds
    • [155] Iciek, M., Kwiecien, I., Wlodek, L., Biological properties of garlic and garlic-derived organosulfur compounds. Environ. Mol. Mutagen. 50 (2009), 247–265.
    • (2009) Environ. Mol. Mutagen. , vol.50 , pp. 247-265
    • Iciek, M.1    Kwiecien, I.2    Wlodek, L.3
  • 156
    • 63049105405 scopus 로고    scopus 로고
    • Modulation of histone deacetylase activity by dietary isothiocyanates and allyl sulfides: studies with sulforaphane and garlic organosulfur compounds
    • [156] Nian, H., Delage, B., Ho, E., Dashwood, R.H., Modulation of histone deacetylase activity by dietary isothiocyanates and allyl sulfides: studies with sulforaphane and garlic organosulfur compounds. Environ. Mol. Mutagen. 50 (2009), 213–221.
    • (2009) Environ. Mol. Mutagen. , vol.50 , pp. 213-221
    • Nian, H.1    Delage, B.2    Ho, E.3    Dashwood, R.H.4
  • 157
    • 0033173102 scopus 로고    scopus 로고
    • Increased acetylation of histones induced by diallyl disulfide and structurally related molecules
    • [157] Lea, M.A., Randolph, V.M., Patel, M., Increased acetylation of histones induced by diallyl disulfide and structurally related molecules. Int. J. Oncol. 15 (1999), 347–352.
    • (1999) Int. J. Oncol. , vol.15 , pp. 347-352
    • Lea, M.A.1    Randolph, V.M.2    Patel, M.3
  • 158
    • 0035876964 scopus 로고    scopus 로고
    • Induction of histone acetylation in mouse erythroleukemia cells by some organosulfur compounds including allyl isothiocyanate
    • [158] Lea, M.A., Randolph, V.M., Lee, J.E., desBordes, C., Induction of histone acetylation in mouse erythroleukemia cells by some organosulfur compounds including allyl isothiocyanate. Int. J. Cancer. 92 (2001), 784–789.
    • (2001) Int. J. Cancer. , vol.92 , pp. 784-789
    • Lea, M.A.1    Randolph, V.M.2    Lee, J.E.3    desBordes, C.4
  • 159
    • 0036437194 scopus 로고    scopus 로고
    • Induction of histone acetylation and inhibition of growth of mouse erythroleukemia cells by S-allylmercaptocysteine
    • [159] Lea, M.A., Rasheed, M., Randolph, V.M., Khan, F., Shareef, A., desBordes, C., Induction of histone acetylation and inhibition of growth of mouse erythroleukemia cells by S-allylmercaptocysteine. Nutr. Cancer 43 (2002), 90–102.
    • (2002) Nutr. Cancer , vol.43 , pp. 90-102
    • Lea, M.A.1    Rasheed, M.2    Randolph, V.M.3    Khan, F.4    Shareef, A.5    desBordes, C.6
  • 160
    • 3242755145 scopus 로고    scopus 로고
    • Diallyl disulfide (DADS) increases histone acetylation and p21(waf1/cip1) expression in human colon tumor cell lines
    • [160] Druesne, N., Pagniez, A., Mayeur, C., Thomas, M., Cherbuy, C., Duée, P.H., et al. Diallyl disulfide (DADS) increases histone acetylation and p21(waf1/cip1) expression in human colon tumor cell lines. Carcinogenesis 25 (2004), 1227–1236.
    • (2004) Carcinogenesis , vol.25 , pp. 1227-1236
    • Druesne, N.1    Pagniez, A.2    Mayeur, C.3    Thomas, M.4    Cherbuy, C.5    Duée, P.H.6
  • 161
    • 51849103354 scopus 로고    scopus 로고
    • Allyl mercaptan a garlic-derived organosulfur compound, inhibits histone deacetylase and enhances Sp3 binding on the P21WAF1 promoter
    • [161] Nian, H., Delage, B., Pinto, J.T., Dashwood, R.H., Allyl mercaptan a garlic-derived organosulfur compound, inhibits histone deacetylase and enhances Sp3 binding on the P21WAF1 promoter. Carcinogenesis 29 (2008), 1816–1824.
    • (2008) Carcinogenesis , vol.29 , pp. 1816-1824
    • Nian, H.1    Delage, B.2    Pinto, J.T.3    Dashwood, R.H.4
  • 162
    • 77449106593 scopus 로고    scopus 로고
    • Molecular targets of dietary phenethyl isothiocyanate and sulforaphane for cancer chemoprevention
    • [162] Cheung, K.L., Kong, A.N., Molecular targets of dietary phenethyl isothiocyanate and sulforaphane for cancer chemoprevention. AAPS J. 12 (2010), 87–97.
    • (2010) AAPS J. , vol.12 , pp. 87-97
    • Cheung, K.L.1    Kong, A.N.2
  • 163
    • 33846217828 scopus 로고    scopus 로고
    • Dual action on promoter demethylation and chromatin by an isothiocyanate restored GSTP1 silenced in prostate cancer
    • [163] Wang, L.G., Beklemisheva, A., Liu, X.M., Ferrari, A.C., Feng, J., Chiao, J.W., Dual action on promoter demethylation and chromatin by an isothiocyanate restored GSTP1 silenced in prostate cancer. Mol. Carcinog. 46 (2007), 24–31.
    • (2007) Mol. Carcinog. , vol.46 , pp. 24-31
    • Wang, L.G.1    Beklemisheva, A.2    Liu, X.M.3    Ferrari, A.C.4    Feng, J.5    Chiao, J.W.6
  • 165
    • 54949113264 scopus 로고    scopus 로고
    • Quercetin is able to demethylate the p16INK4a gene promoter
    • [165] Tan, S., Wang, C., Lu, C., Zhao, B., Cui, Y., Shi, X., et al. Quercetin is able to demethylate the p16INK4a gene promoter. Chemotherapy 55 (2009), 6–10.
    • (2009) Chemotherapy , vol.55 , pp. 6-10
    • Tan, S.1    Wang, C.2    Lu, C.3    Zhao, B.4    Cui, Y.5    Shi, X.6
  • 166
    • 34247872831 scopus 로고    scopus 로고
    • Quercetin inhibits TNF-induced NF-kappaB transcription factor recruitment to proinflammatory gene promoters in murine intestinal epithelial cells
    • [166] Ruiz, P.A., Braune, A., Holzlwimmer, G., Quintanilla-Fend, L., Haller, D., Quercetin inhibits TNF-induced NF-kappaB transcription factor recruitment to proinflammatory gene promoters in murine intestinal epithelial cells. J. Nutr. 137 (2007), 1208–1215.
    • (2007) J. Nutr. , vol.137 , pp. 1208-1215
    • Ruiz, P.A.1    Braune, A.2    Holzlwimmer, G.3    Quintanilla-Fend, L.4    Haller, D.5
  • 167
    • 78651347259 scopus 로고    scopus 로고
    • Quercetin induces FasL-related apoptosis, in part, through promotion of histone H3 acetylation in human leukemia HL-60 cells
    • [167] Lee, W.J., Chen, Y.R., Tseng, T.H., Quercetin induces FasL-related apoptosis, in part, through promotion of histone H3 acetylation in human leukemia HL-60 cells. Oncol. Rep. 25 (2011), 583–591.
    • (2011) Oncol. Rep. , vol.25 , pp. 583-591
    • Lee, W.J.1    Chen, Y.R.2    Tseng, T.H.3
  • 168
    • 79951915882 scopus 로고    scopus 로고
    • The flavonoid quercetin modulates the hallmark capabilities of hamster buccal pouch tumors
    • [168] Priyadarsini, R.V., Vinothini, G., Murugan, R.S., Manikandan, P., Nagini, S., The flavonoid quercetin modulates the hallmark capabilities of hamster buccal pouch tumors. Nutr. Cancer. 63 (2011), 218–226.
    • (2011) Nutr. Cancer. , vol.63 , pp. 218-226
    • Priyadarsini, R.V.1    Vinothini, G.2    Murugan, R.S.3    Manikandan, P.4    Nagini, S.5
  • 170
    • 84874939431 scopus 로고    scopus 로고
    • Synthesis and characterization of a SIRT6 open tubular column: predicting deacetylation activity using frontal chromatography
    • [170] Singh, N., Ravichandran, S., Norton, D.D., Fugmann, S.D., Moaddel, R., Synthesis and characterization of a SIRT6 open tubular column: predicting deacetylation activity using frontal chromatography. Anal. Biochem. 436 (2013), 78–83.
    • (2013) Anal. Biochem. , vol.436 , pp. 78-83
    • Singh, N.1    Ravichandran, S.2    Norton, D.D.3    Fugmann, S.D.4    Moaddel, R.5
  • 172
    • 84940838142 scopus 로고    scopus 로고
    • MicroRNA-143 enhances chemosensitivity of Quercetin through autophagy inhibition via target GABARAPL1 in gastric cancer cells
    • [172] Du, F., Feng, Y., Fang, J., Yang, M., MicroRNA-143 enhances chemosensitivity of Quercetin through autophagy inhibition via target GABARAPL1 in gastric cancer cells. Biomed. Pharmacother. 74 (2015), 169–177.
    • (2015) Biomed. Pharmacother. , vol.74 , pp. 169-177
    • Du, F.1    Feng, Y.2    Fang, J.3    Yang, M.4
  • 173
    • 84930960190 scopus 로고    scopus 로고
    • Quercetin decreases claudin-2 expression mediated by up-Regulation of microRNA miR-16 in lung adenocarcinoma A549Cells
    • [173] Sonoki, H., Sato, T., Endo, S., Matsunaga, T., Yamaguchi, M., Yamazaki, Y., et al. Quercetin decreases claudin-2 expression mediated by up-Regulation of microRNA miR-16 in lung adenocarcinoma A549Cells. Nutrients 7 (2015), 4578–4592.
    • (2015) Nutrients , vol.7 , pp. 4578-4592
    • Sonoki, H.1    Sato, T.2    Endo, S.3    Matsunaga, T.4    Yamaguchi, M.5    Yamazaki, Y.6
  • 174
    • 84928139602 scopus 로고    scopus 로고
    • The p53/miR-34a/SIRT1 positive feedback loop in quercetin induced apoptosis
    • [174] Lou, G., Liu, Y., Wu, S., Xue, J., Yang, F., Fu, H., et al. The p53/miR-34a/SIRT1 positive feedback loop in quercetin induced apoptosis. Cell Physiol. Biochem. 35 (2015), 2192–2202.
    • (2015) Cell Physiol. Biochem. , vol.35 , pp. 2192-2202
    • Lou, G.1    Liu, Y.2    Wu, S.3    Xue, J.4    Yang, F.5    Fu, H.6
  • 175
    • 84950280761 scopus 로고    scopus 로고
    • Quercetin enhances cisplatin sensitivity of human osteosarcoma cells by modulating microRNA-217-KRAS axis
    • [175] Zhang, X., Guo, Q., Chen, J., Chen, Z., Quercetin enhances cisplatin sensitivity of human osteosarcoma cells by modulating microRNA-217-KRAS axis. Mol. Cells 38 (2015), 638–642.
    • (2015) Mol. Cells , vol.38 , pp. 638-642
    • Zhang, X.1    Guo, Q.2    Chen, J.3    Chen, Z.4
  • 176
    • 84916210567 scopus 로고    scopus 로고
    • Zheng JH.Combination of quercetin and hyperoside inhibits prostate cancer cell growth and metastasis via regulation of microRNA-21
    • [176] Yang, F.Q., Liu, M., Li, W., Che, J.P., Wang, G.C., Zheng JH.Combination of quercetin and hyperoside inhibits prostate cancer cell growth and metastasis via regulation of microRNA-21. Mol. Med. Rep. 11 (2015), 1085–1092.
    • (2015) Mol. Med. Rep. , vol.11 , pp. 1085-1092
    • Yang, F.Q.1    Liu, M.2    Li, W.3    Che, J.P.4    Wang, G.C.5
  • 177
  • 178
  • 179
    • 53149137486 scopus 로고    scopus 로고
    • Impaired DNA damage response, genome instability, and tumorigenesis in SIRT1 mutant mice
    • [179] Wang, R.H., Sengupta, K., Li, C., Kim, H.S., Cao, L., Xiao, C., et al. Impaired DNA damage response, genome instability, and tumorigenesis in SIRT1 mutant mice. Cancer Cell 14 (2008), 312–323.
    • (2008) Cancer Cell , vol.14 , pp. 312-323
    • Wang, R.H.1    Sengupta, K.2    Li, C.3    Kim, H.S.4    Cao, L.5    Xiao, C.6
  • 180
    • 0141719702 scopus 로고    scopus 로고
    • Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan
    • [180] Howitz, K.T., Bitterman, K.J., Cohen, H.Y., Lamming, D.W., Lavu, S., Wood, J.G., et al. Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan. Nature 425 (2003), 191–196.
    • (2003) Nature , vol.425 , pp. 191-196
    • Howitz, K.T.1    Bitterman, K.J.2    Cohen, H.Y.3    Lamming, D.W.4    Lavu, S.5    Wood, J.G.6
  • 181
    • 67650297506 scopus 로고    scopus 로고
    • Cancer prevention and treatment with resveratrol: from rodent studies to clinical trials
    • [181] Bishayee, A., Cancer prevention and treatment with resveratrol: from rodent studies to clinical trials. Cancer Prev. Res. (Phila) 2 (2009), 409–418.
    • (2009) Cancer Prev. Res. (Phila) , vol.2 , pp. 409-418
    • Bishayee, A.1
  • 182
    • 3943071801 scopus 로고    scopus 로고
    • Sirtuin activators mimic caloric restriction and delay ageing in metazoans
    • [182] Wood, J.G., Rogina, B., Lavu, S., Howitz, K., Helfand, S.L., Tatar, M., et al. Sirtuin activators mimic caloric restriction and delay ageing in metazoans. Nature 430 (2004), 686–689.
    • (2004) Nature , vol.430 , pp. 686-689
    • Wood, J.G.1    Rogina, B.2    Lavu, S.3    Howitz, K.4    Helfand, S.L.5    Tatar, M.6
  • 183
    • 68949113934 scopus 로고    scopus 로고
    • SirT1-null mice develop tumors at normal rates but are poorly protected by resveratrol
    • [183] Boily, G., He, X.H., Pearce, B., Jardine, K., McBurney, M.W., SirT1-null mice develop tumors at normal rates but are poorly protected by resveratrol. Oncogene 28 (2009), 2882–2893.
    • (2009) Oncogene , vol.28 , pp. 2882-2893
    • Boily, G.1    He, X.H.2    Pearce, B.3    Jardine, K.4    McBurney, M.W.5
  • 184
    • 53149144656 scopus 로고    scopus 로고
    • Interplay among BRCA1, SIRT1, and survivin during BRCA1-associated tumorigenesis
    • [184] Wang, R.H., Zheng, Y., Kim, H.S., Xu, X., Cao, L., Luhasen, T., et al. Interplay among BRCA1, SIRT1, and survivin during BRCA1-associated tumorigenesis. Mol. Cell. 32 (2008), 11–20.
    • (2008) Mol. Cell. , vol.32 , pp. 11-20
    • Wang, R.H.1    Zheng, Y.2    Kim, H.S.3    Xu, X.4    Cao, L.5    Luhasen, T.6
  • 185
    • 77449099964 scopus 로고    scopus 로고
    • Resveratrol enhances p53 acetylation and apoptosis in prostate cancer by inhibiting MTA1/NuRD complex
    • [185] Kai, L., Samuel, S.K., Levenson, A.S., Resveratrol enhances p53 acetylation and apoptosis in prostate cancer by inhibiting MTA1/NuRD complex. Int. J. Cancer 126 (2010), 1538–1548.
    • (2010) Int. J. Cancer , vol.126 , pp. 1538-1548
    • Kai, L.1    Samuel, S.K.2    Levenson, A.S.3
  • 186
    • 84959143809 scopus 로고    scopus 로고
    • Epigenetic-based combinatorial resveratrol and pterostilbene alters DNA damage response by affecting SIRT1 and DNMT enzyme expression, including SIRT1-dependent γ-H2AX and telomerase regulation in triple-negative breast cancer
    • [186] Kala, R., Shah, H.N., Martin, S.L., Tollefsbol, T.O., Epigenetic-based combinatorial resveratrol and pterostilbene alters DNA damage response by affecting SIRT1 and DNMT enzyme expression, including SIRT1-dependent γ-H2AX and telomerase regulation in triple-negative breast cancer. BMC Cancer, 15, 2015, 672.
    • (2015) BMC Cancer , vol.15 , pp. 672
    • Kala, R.1    Shah, H.N.2    Martin, S.L.3    Tollefsbol, T.O.4
  • 187
    • 84896105051 scopus 로고    scopus 로고
    • Shortterm resveratrol exposure causes in vitro and in vivo growth inhibition and apoptosis of bladder cancer cells
    • [187] Wu, M.L., Li, H., Yu, L.J., Chen, X.Y., Kong, Q.Y., Song, X., et al. Shortterm resveratrol exposure causes in vitro and in vivo growth inhibition and apoptosis of bladder cancer cells. PLoS One, 9, 2014, e89806.
    • (2014) PLoS One , vol.9 , pp. e89806
    • Wu, M.L.1    Li, H.2    Yu, L.J.3    Chen, X.Y.4    Kong, Q.Y.5    Song, X.6
  • 188
    • 84895078313 scopus 로고    scopus 로고
    • Methylation and miRNA effects of resveratrol on mammary tumors vs normal tissue
    • [188] Qin, W., Zhang, K., Clarke, K., Weiland, T., Sauter, E.R., Methylation and miRNA effects of resveratrol on mammary tumors vs normal tissue. Nutr. Cancer 66 (2014), 270–277.
    • (2014) Nutr. Cancer , vol.66 , pp. 270-277
    • Qin, W.1    Zhang, K.2    Clarke, K.3    Weiland, T.4    Sauter, E.R.5
  • 189
    • 84924755849 scopus 로고    scopus 로고
    • Gestational exposure to the AhR agonist 2,3,7,8-tetrachlorodibenzo-p-dioxin induces BRCA-1 promoter hypermethylation and reduces BRCA-1 expression in mammary tissue of rat offspring:Preventive effects of resveratrol
    • [189] Papoutsis, A.J., Selmin, O.I., Borg, J.L., Romagnolo, D.F., Gestational exposure to the AhR agonist 2,3,7,8-tetrachlorodibenzo-p-dioxin induces BRCA-1 promoter hypermethylation and reduces BRCA-1 expression in mammary tissue of rat offspring:Preventive effects of resveratrol. Mol. Carcinog. 54 (2015), 261–269.
    • (2015) Mol. Carcinog. , vol.54 , pp. 261-269
    • Papoutsis, A.J.1    Selmin, O.I.2    Borg, J.L.3    Romagnolo, D.F.4
  • 190
    • 84944463738 scopus 로고    scopus 로고
    • Time – and concentration – dependent effects of resveratrol on miR 15a and miR16-1Expression and apoptosis in the CCRF-CEM acute lymphoblastic leukemia cell line
    • [190] Azimi, A., Hagh, M.F., Talebi, M., Yousefi, B., Hossein Pour Feizi, A.A., Baradaran, B., et al. Time – and concentration – dependent effects of resveratrol on miR 15a and miR16-1Expression and apoptosis in the CCRF-CEM acute lymphoblastic leukemia cell line. Asian Pac. J. Cancer Prev. 16 (2015), 6463–6468.
    • (2015) Asian Pac. J. Cancer Prev. , vol.16 , pp. 6463-6468
    • Azimi, A.1    Hagh, M.F.2    Talebi, M.3    Yousefi, B.4    Hossein Pour Feizi, A.A.5    Baradaran, B.6
  • 191
    • 84944472691 scopus 로고    scopus 로고
    • Resveratrol and pterostilbene epigenetically restore PTEN expression by targeting oncomiRs of the miR-17 family in prostate cancer
    • [191] Dhar, S., Kumar, A., Rimando, A.M., Zhang, X., Levenson, A.S., Resveratrol and pterostilbene epigenetically restore PTEN expression by targeting oncomiRs of the miR-17 family in prostate cancer. Oncotarget 6 (2015), 27214–27226.
    • (2015) Oncotarget , vol.6 , pp. 27214-27226
    • Dhar, S.1    Kumar, A.2    Rimando, A.M.3    Zhang, X.4    Levenson, A.S.5
  • 192
    • 51349088974 scopus 로고    scopus 로고
    • Multi-targeted prevention of cancer by sulforaphane
    • [192] Clarke, J.D., Dashwood, R.H., Ho, E., Multi-targeted prevention of cancer by sulforaphane. Cancer Lett. 269 (2008), 291–304.
    • (2008) Cancer Lett. , vol.269 , pp. 291-304
    • Clarke, J.D.1    Dashwood, R.H.2    Ho, E.3
  • 193
    • 79952723845 scopus 로고    scopus 로고
    • Sulforaphane–a possible agent in prevention and therapy of cancer
    • [193] Tomczyk, J., Olejnik, A., Sulforaphane–a possible agent in prevention and therapy of cancer. Postepy Hig. Med. Dosw. 64 (2010), 590–603.
    • (2010) Postepy Hig. Med. Dosw. , vol.64 , pp. 590-603
    • Tomczyk, J.1    Olejnik, A.2
  • 194
    • 23244450241 scopus 로고    scopus 로고
    • Transcriptome analysis of human colon Caco-2 cells exposed to sulforaphane
    • [194] Traka, M., Gasper, A.V., Smith, J.A., Hawkey, C.J., Bao, Y., Mithen, R.F., Transcriptome analysis of human colon Caco-2 cells exposed to sulforaphane. J. Nutr. 135 (2005), 1865–1872.
    • (2005) J. Nutr. , vol.135 , pp. 1865-1872
    • Traka, M.1    Gasper, A.V.2    Smith, J.A.3    Hawkey, C.J.4    Bao, Y.5    Mithen, R.F.6
  • 195
    • 77955352742 scopus 로고    scopus 로고
    • Sulforaphane causes epigenetic repression of hTERT expression in human breast cancer cell lines
    • [195] Meeran, S.M., Patel, S.N., Tollefsbol, T.O., Sulforaphane causes epigenetic repression of hTERT expression in human breast cancer cell lines. PLoS One, 5, 2010, e11457.
    • (2010) PLoS One , vol.5 , pp. e11457
    • Meeran, S.M.1    Patel, S.N.2    Tollefsbol, T.O.3
  • 196
    • 4143130097 scopus 로고    scopus 로고
    • A novel mechanism of chemoprotection by sulforaphane: inhibition of histone deacetylase
    • [196] Myzak, M.C., Karplus, P.A., Chung, F.L., Dashwood, R.H., A novel mechanism of chemoprotection by sulforaphane: inhibition of histone deacetylase. Cancer Res. 64 (2004), 5767–5774.
    • (2004) Cancer Res. , vol.64 , pp. 5767-5774
    • Myzak, M.C.1    Karplus, P.A.2    Chung, F.L.3    Dashwood, R.H.4
  • 197
    • 33645324413 scopus 로고    scopus 로고
    • Sulforaphane inhibits histone deacetylase activity in BpH −1, LnCaP and PC-3 prostate epithelial cells
    • [197] Myzak, M.C., Hardin, K., Wang, R., Dashwood, R.H., Ho, E., Sulforaphane inhibits histone deacetylase activity in BpH −1, LnCaP and PC-3 prostate epithelial cells. Carcinogenesis 27 (2006), 811–819.
    • (2006) Carcinogenesis , vol.27 , pp. 811-819
    • Myzak, M.C.1    Hardin, K.2    Wang, R.3    Dashwood, R.H.4    Ho, E.5
  • 198
    • 34147135143 scopus 로고    scopus 로고
    • Sulforaphane induces cell type-specific apoptosis in human breast cancer cell lines
    • [198] Pledgie-Tracy, A., Sobolewski, M.D., Davidson, N.E., Sulforaphane induces cell type-specific apoptosis in human breast cancer cell lines. Mol. Cancer Ther. 6 (2007), 1013–1021.
    • (2007) Mol. Cancer Ther. , vol.6 , pp. 1013-1021
    • Pledgie-Tracy, A.1    Sobolewski, M.D.2    Davidson, N.E.3
  • 199
    • 84898889926 scopus 로고    scopus 로고
    • Andres Houseman E, et al Effects of sulforaphane and 3,3′-diindolylmethane on genome-wide promoter methylation in normal prostate epithelial cells and prostate cancer cells
    • [199] Wong, C.P., Hsu, A., Buchanan, A., Palomera-Sanchez, Z., Beaver, L.M., Andres Houseman E, et al Effects of sulforaphane and 3,3′-diindolylmethane on genome-wide promoter methylation in normal prostate epithelial cells and prostate cancer cells. PLoS One, 9, 2014, e86787.
    • (2014) PLoS One , vol.9 , pp. e86787
    • Wong, C.P.1    Hsu, A.2    Buchanan, A.3    Palomera-Sanchez, Z.4    Beaver, L.M.5
  • 200
    • 84897130844 scopus 로고    scopus 로고
    • Requirement and epigenetics reprogramming of Nrf2 in suppression of tumor promoter TPA-induced mouse skin cell transformation by sulforaphane
    • [200] Su, Z.Y., Zhang, C., Lee, J.H., Shu, L., Wu, T.Y., Khor, T.O., et al. Requirement and epigenetics reprogramming of Nrf2 in suppression of tumor promoter TPA-induced mouse skin cell transformation by sulforaphane. Cancer Prev. Res. 7 (2014), 319–329.
    • (2014) Cancer Prev. Res. , vol.7 , pp. 319-329
    • Su, Z.Y.1    Zhang, C.2    Lee, J.H.3    Shu, L.4    Wu, T.Y.5    Khor, T.O.6
  • 201
    • 84948799646 scopus 로고    scopus 로고
    • Polyphenols as modulator of oxidative stress in cancer disease: new therapeutic strategies
    • [201] Mileo, A.M., Miccadei, S., Polyphenols as modulator of oxidative stress in cancer disease: new therapeutic strategies. Oxid. Med. Cell. Longevity, 2016, 2016, 6475624, 10.1155/2016/6475624.
    • (2016) Oxid. Med. Cell. Longevity , vol.2016 , pp. 6475624
    • Mileo, A.M.1    Miccadei, S.2
  • 202
    • 33645825587 scopus 로고    scopus 로고
    • Sulforaphane inhibits histone deacetylase in vivo and suppresses tumorigenesis in Apc-minus mice
    • [202] Myzak, M.C., Dashwood, W.M., Orner, G.A., Ho, E., Dashwood, R.H., Sulforaphane inhibits histone deacetylase in vivo and suppresses tumorigenesis in Apc-minus mice. FASEB J. 20 (2006), 506–508.
    • (2006) FASEB J. , vol.20 , pp. 506-508
    • Myzak, M.C.1    Dashwood, W.M.2    Orner, G.A.3    Ho, E.4    Dashwood, R.H.5
  • 203
    • 33846838750 scopus 로고    scopus 로고
    • Sulforaphane retards the growth of human PC-3 xenografts and inhibits HDAC activity in human subjects
    • [203] Myzak, M.C., Tong, P., Dashwood, W.M., Dashwood, R.H., Ho, E., Sulforaphane retards the growth of human PC-3 xenografts and inhibits HDAC activity in human subjects. Exp. Biol. Med. (Maywood) 232 (2007), 227–234.
    • (2007) Exp. Biol. Med. (Maywood) , vol.232 , pp. 227-234
    • Myzak, M.C.1    Tong, P.2    Dashwood, W.M.3    Dashwood, R.H.4    Ho, E.5
  • 204
    • 25144507259 scopus 로고    scopus 로고
    • Mechanisms for the inhibition of DNA methyltransferases by tea catechins and bioflavonoids
    • [204] Lee, W.J., Shim, J.Y., Zhu, B.T., Mechanisms for the inhibition of DNA methyltransferases by tea catechins and bioflavonoids. Mol. Pharmacol. 68 (2005), 1018–1030.
    • (2005) Mol. Pharmacol. , vol.68 , pp. 1018-1030
    • Lee, W.J.1    Shim, J.Y.2    Zhu, B.T.3
  • 205
    • 57349118457 scopus 로고    scopus 로고
    • EGCG stabilizes p27kip1 in E2-stimulated MCF-7 cells through down-regulation of the Skp2 protein
    • [205] Huang, H.C., Way, T.D., Lin, C.L., Lin, J.K., EGCG stabilizes p27kip1 in E2-stimulated MCF-7 cells through down-regulation of the Skp2 protein. Endocrinology 149 (2008), 5972–5983.
    • (2008) Endocrinology , vol.149 , pp. 5972-5983
    • Huang, H.C.1    Way, T.D.2    Lin, C.L.3    Lin, J.K.4
  • 208
    • 49549087270 scopus 로고    scopus 로고
    • Effects of green tea polyphenol on methylation status of RECK gene and cancer cell invasion in oral squamous cell carcinoma cells
    • [208] Kato, K., Long, N.K., Makita, H., Toida, M., Yamashita, T., Hatakeyama, D., et al. Effects of green tea polyphenol on methylation status of RECK gene and cancer cell invasion in oral squamous cell carcinoma cells. Br. J. Cancer. 99 (2008), 647–665.
    • (2008) Br. J. Cancer. , vol.99 , pp. 647-665
    • Kato, K.1    Long, N.K.2    Makita, H.3    Toida, M.4    Yamashita, T.5    Hatakeyama, D.6
  • 209
    • 57349126317 scopus 로고    scopus 로고
    • Persistent hypomethylation in the promoter of nucleosomal binding protein 1 (Nsbp1) correlates with overexpression of Nsbp1 in mouse uteri neonatally exposed to diethylstilbestrol or genistein
    • [209] Tang, W.Y., Newbold, R., Mardilovich, K., Jefferson, W., Cheng, R.Y., Medvedovic, M., et al. Persistent hypomethylation in the promoter of nucleosomal binding protein 1 (Nsbp1) correlates with overexpression of Nsbp1 in mouse uteri neonatally exposed to diethylstilbestrol or genistein. Endocrinology 149 (2008), 5922–5931.
    • (2008) Endocrinology , vol.149 , pp. 5922-5931
    • Tang, W.Y.1    Newbold, R.2    Mardilovich, K.3    Jefferson, W.4    Cheng, R.Y.5    Medvedovic, M.6
  • 210
    • 20344382068 scopus 로고    scopus 로고
    • Promoter hypermethylation and inactivation of O(6)-methylguanine-DNA methyltransferase in esophageal squamous cell carcinomas and its reactivation in cell lines
    • [210] Fang, M.Z., Jin, Z., Wang, Y., Liao, J., Yang, G.Y., Wang, L.D., et al. Promoter hypermethylation and inactivation of O(6)-methylguanine-DNA methyltransferase in esophageal squamous cell carcinomas and its reactivation in cell lines. Int. J. Oncol. 26 (2005), 615–622.
    • (2005) Int. J. Oncol. , vol.26 , pp. 615-622
    • Fang, M.Z.1    Jin, Z.2    Wang, Y.3    Liao, J.4    Yang, G.Y.5    Wang, L.D.6
  • 212
    • 73749085369 scopus 로고    scopus 로고
    • The effect of dietary polyphenols on the epigenetic regulation of gene expression in MCF7 breast cancer cells
    • [212] Paluszczak, J., Krajka-Kuźniak, V., Baer-Dubowska, W., The effect of dietary polyphenols on the epigenetic regulation of gene expression in MCF7 breast cancer cells. Toxicol. Lett. 192 (2010), 119–125.
    • (2010) Toxicol. Lett. , vol.192 , pp. 119-125
    • Paluszczak, J.1    Krajka-Kuźniak, V.2    Baer-Dubowska, W.3
  • 213
    • 77953539793 scopus 로고    scopus 로고
    • Hypomethylation and induction of retinoic acid receptor beta 2 by concurrent action of adenosine analogues and natural compounds in breast cancer cells
    • [213] Stefanska, B., Rudnicka, K., Bednarek, A., Fabianowska-Majewska, K., Hypomethylation and induction of retinoic acid receptor beta 2 by concurrent action of adenosine analogues and natural compounds in breast cancer cells. Eur. J. Pharmacol. 638 (2010), 47–53.
    • (2010) Eur. J. Pharmacol. , vol.638 , pp. 47-53
    • Stefanska, B.1    Rudnicka, K.2    Bednarek, A.3    Fabianowska-Majewska, K.4
  • 214
    • 70549091994 scopus 로고    scopus 로고
    • Computational screening of molecular targets in Plasmodium for novel non-resistant anti-malarial drugs
    • [214] Singh, N., Misra, K., Computational screening of molecular targets in Plasmodium for novel non-resistant anti-malarial drugs. Bioinformation 3 (2009), 255–262.
    • (2009) Bioinformation , vol.3 , pp. 255-262
    • Singh, N.1    Misra, K.2
  • 215
    • 15744370742 scopus 로고    scopus 로고
    • Curcumin-induced histone hypoacetylation: the role of reactive oxygen species
    • [215] Kang, J., Chen, J., Shi, Y., Jia, J., Zhang, Y., Curcumin-induced histone hypoacetylation: the role of reactive oxygen species. Biochem. Pharmacol. 69 (2005), 1205–1213.
    • (2005) Biochem. Pharmacol. , vol.69 , pp. 1205-1213
    • Kang, J.1    Chen, J.2    Shi, Y.3    Jia, J.4    Zhang, Y.5
  • 216
    • 34447546839 scopus 로고    scopus 로고
    • PfGCN5-mediated histone H3 acetylation plays a key role in gene expression in Plasmodium falciparum
    • [216] Cui, L., Miao, J., Furuya, T., Li, X., Su, X.Z., Cui, L., PfGCN5-mediated histone H3 acetylation plays a key role in gene expression in Plasmodium falciparum. Eukaryot. Cell 6 (2007), 1219–1227.
    • (2007) Eukaryot. Cell , vol.6 , pp. 1219-1227
    • Cui, L.1    Miao, J.2    Furuya, T.3    Li, X.4    Su, X.Z.5    Cui, L.6
  • 217
    • 33645059712 scopus 로고    scopus 로고
    • Histone modifications in kainate-induced status epilepticus
    • [217] Sng, J.C., Taniura, H., Yoneda, Y., Histone modifications in kainate-induced status epilepticus. Eur. J. Neurosci. 23 (2006), 1269–1282.
    • (2006) Eur. J. Neurosci. , vol.23 , pp. 1269-1282
    • Sng, J.C.1    Taniura, H.2    Yoneda, Y.3
  • 218
    • 67651182607 scopus 로고    scopus 로고
    • Curcumin prevents diabetes-associated abnormalities in the kidneys by inhibiting p300 and nuclear factor-kappaB
    • [218] Chiu, J., Khan, Z.A., Farhangkhoee, H., Chakrabarti, S., Curcumin prevents diabetes-associated abnormalities in the kidneys by inhibiting p300 and nuclear factor-kappaB. Nutrition 25 (2009), 964–972.
    • (2009) Nutrition , vol.25 , pp. 964-972
    • Chiu, J.1    Khan, Z.A.2    Farhangkhoee, H.3    Chakrabarti, S.4
  • 219
    • 40949119020 scopus 로고    scopus 로고
    • Change in post-translational modifications of histone H3, heat-shock protein-27 and MAP kinase p38 expression by curcumin in streptozotocin-induced type I diabetic nephropathy
    • [219] Tikoo, K., Meena, R.L., Kabra, D.G., Gaikwad, A.B., Change in post-translational modifications of histone H3, heat-shock protein-27 and MAP kinase p38 expression by curcumin in streptozotocin-induced type I diabetic nephropathy. Br. J. Pharmacol. 153 (2008), 1225–1231.
    • (2008) Br. J. Pharmacol. , vol.153 , pp. 1225-1231
    • Tikoo, K.1    Meena, R.L.2    Kabra, D.G.3    Gaikwad, A.B.4
  • 221
    • 40549135974 scopus 로고    scopus 로고
    • The dietary compound curcumin inhibits p300 histone acetyltransferase activity and prevents heart failure in rats
    • [221] Morimoto, T., Sunagawa, Y., Kawamura, T., Takaya, T., Wada, H., Nagasawa, A., et al. The dietary compound curcumin inhibits p300 histone acetyltransferase activity and prevents heart failure in rats. J. Clin. Invest. 118 (2008), 868–878.
    • (2008) J. Clin. Invest. , vol.118 , pp. 868-878
    • Morimoto, T.1    Sunagawa, Y.2    Kawamura, T.3    Takaya, T.4    Wada, H.5    Nagasawa, A.6
  • 222
    • 18744403080 scopus 로고    scopus 로고
    • Curcumin a potent anti-tumor reagent, is a novel histone deacetylase inhibitor regulating B-NHL cell line Raji proliferation
    • [222] Liu, H.L., Chen, Y., Cui, G.H., Zhou, J.F., Curcumin a potent anti-tumor reagent, is a novel histone deacetylase inhibitor regulating B-NHL cell line Raji proliferation. Acta Pharmacol. Sin. 26 (2005), 603–609.
    • (2005) Acta Pharmacol. Sin. , vol.26 , pp. 603-609
    • Liu, H.L.1    Chen, Y.2    Cui, G.H.3    Zhou, J.F.4
  • 223
    • 58349094740 scopus 로고    scopus 로고
    • Epigallocatechin-3-gallate, a histone acetyltransferase inhibitor, inhibits EBV-induced B lymphocyte transformation via suppression of RelA acetylation
    • [223] Choi, K.C., Jung, M.G., Lee, Y.H., Yoon, J.C., Kwon, S.H., Kang, H.B., et al. Epigallocatechin-3-gallate, a histone acetyltransferase inhibitor, inhibits EBV-induced B lymphocyte transformation via suppression of RelA acetylation. Cancer Res. 69 (2009), 583–592.
    • (2009) Cancer Res. , vol.69 , pp. 583-592
    • Choi, K.C.1    Jung, M.G.2    Lee, Y.H.3    Yoon, J.C.4    Kwon, S.H.5    Kang, H.B.6
  • 224
    • 0035156867 scopus 로고    scopus 로고
    • Induction of histone acetylation in rat liver and hepatoma by organosulfur compounds including diallyl disulfide
    • [224] Lea, M.A., Randolph, V.M., Induction of histone acetylation in rat liver and hepatoma by organosulfur compounds including diallyl disulfide. Anticancer Res. 21 (2001), 2841–2845.
    • (2001) Anticancer Res. , vol.21 , pp. 2841-2845
    • Lea, M.A.1    Randolph, V.M.2
  • 225
    • 51249112155 scopus 로고    scopus 로고
    • The dietary histone deacetylase inhibitor sulforaphane induces human beta-defensin-2 in intestinal epithelial cells
    • [225] Schwab, M., Reynders, V., Loitsch, S., Steinhilber, D., Schroder, O., Stein, J., The dietary histone deacetylase inhibitor sulforaphane induces human beta-defensin-2 in intestinal epithelial cells. Immunology 125 (2008), 241–251.
    • (2008) Immunology , vol.125 , pp. 241-251
    • Schwab, M.1    Reynders, V.2    Loitsch, S.3    Steinhilber, D.4    Schroder, O.5    Stein, J.6
  • 226
    • 33749581701 scopus 로고    scopus 로고
    • Cancer chemoprevention of intestinal polyposis in ApcMin/+ mice by sulforaphane, a natural product derived from cruciferous vegetable
    • [226] Hu, R., Khor, T.O., Shen, G., Jeong, W.S., Hebbar, V., Chen, C., et al. Cancer chemoprevention of intestinal polyposis in ApcMin/+ mice by sulforaphane, a natural product derived from cruciferous vegetable. Carcinogenesis 27 (2006), 2038–2046.
    • (2006) Carcinogenesis , vol.27 , pp. 2038-2046
    • Hu, R.1    Khor, T.O.2    Shen, G.3    Jeong, W.S.4    Hebbar, V.5    Chen, C.6
  • 227
    • 34147135143 scopus 로고    scopus 로고
    • Sulforaphane induces cell type-specific apoptosis in human breast cancer cell lines
    • [227] Pledgie-Tracy, A., Sobolewski, M.D., Davidson, N.E., Sulforaphane induces cell type-specific apoptosis in human breast cancer cell lines. Mol. Cancer Ther. 6 (2007), 1013–1021.
    • (2007) Mol. Cancer Ther. , vol.6 , pp. 1013-1021
    • Pledgie-Tracy, A.1    Sobolewski, M.D.2    Davidson, N.E.3
  • 228
    • 84860249089 scopus 로고    scopus 로고
    • Alterations in expression of specific microRNAs by combination of 4-HPR and EGCG inhibited growth of human malignant neuroblastoma cells
    • [228] Chakrabarti, M., Khandkar, M., Banik, N.L., Ray, S.K., Alterations in expression of specific microRNAs by combination of 4-HPR and EGCG inhibited growth of human malignant neuroblastoma cells. Brain Res. 1454 (2012), 1–13.
    • (2012) Brain Res. , vol.1454 , pp. 1-13
    • Chakrabarti, M.1    Khandkar, M.2    Banik, N.L.3    Ray, S.K.4
  • 229
    • 84877920467 scopus 로고    scopus 로고
    • miR-138 overexpression is more powerful than hTERT knockdown to potentiate apigenin for apoptosis in neuroblastoma in vitro and in vivo
    • [229] Chakrabarti, M., Banik, N.L., Ray, S.K., miR-138 overexpression is more powerful than hTERT knockdown to potentiate apigenin for apoptosis in neuroblastoma in vitro and in vivo. Exp. Cell Res. 319 (2013), 1575–1585.
    • (2013) Exp. Cell Res. , vol.319 , pp. 1575-1585
    • Chakrabarti, M.1    Banik, N.L.2    Ray, S.K.3
  • 230
    • 80051827246 scopus 로고    scopus 로고
    • MicroRNA HSA-miR-125a-5p induces apoptosis by activating p53 in lung cancer cells
    • [230] Jiang, L., Huang, Q., Chang, J., Wang, E., Qiu, X., MicroRNA HSA-miR-125a-5p induces apoptosis by activating p53 in lung cancer cells. Exp. Lung Res. 37 (2011), 387–398.
    • (2011) Exp. Lung Res. , vol.37 , pp. 387-398
    • Jiang, L.1    Huang, Q.2    Chang, J.3    Wang, E.4    Qiu, X.5
  • 231
    • 80053905142 scopus 로고    scopus 로고
    • Curcumin modulates microRNA-203-mediated regulation of the Src-Akt axis in bladder cancer
    • [231] Saini, S., Arora, S., Majid, S., Shahryari, V., Chen, Y., Deng, G., et al. Curcumin modulates microRNA-203-mediated regulation of the Src-Akt axis in bladder cancer. Cancer Prev. Res. (Phila.) 4 (2011), 1698–1709.
    • (2011) Cancer Prev. Res. (Phila.) , vol.4 , pp. 1698-1709
    • Saini, S.1    Arora, S.2    Majid, S.3    Shahryari, V.4    Chen, Y.5    Deng, G.6
  • 232
    • 78149342035 scopus 로고    scopus 로고
    • Curcumin promotes apoptosis in human lung adenocarcinoma cells through miR-186n signaling pathway
    • [232] Zhang, J., Du, Y., Wu, C., Ren, X., Ti, X., Shi, J., et al. Curcumin promotes apoptosis in human lung adenocarcinoma cells through miR-186n signaling pathway. Oncol. Rep. 24 (2010), 1217–1223.
    • (2010) Oncol. Rep. , vol.24 , pp. 1217-1223
    • Zhang, J.1    Du, Y.2    Wu, C.3    Ren, X.4    Ti, X.5    Shi, J.6
  • 233
    • 84862831802 scopus 로고    scopus 로고
    • Pure curcumin decreases the expression of WT1 by upregulation of miR-15a and miR-16-1 in leukemic cells
    • [233] Gao, S.M., Yang, J.J., Chen, C.Q., Chen, J.J., Ye, L.P., Wang, L.Y., et al. Pure curcumin decreases the expression of WT1 by upregulation of miR-15a and miR-16-1 in leukemic cells. J. Exp. Clin. Cancer Res., 31, 2012, 27.
    • (2012) J. Exp. Clin. Cancer Res. , vol.31 , pp. 27
    • Gao, S.M.1    Yang, J.J.2    Chen, C.Q.3    Chen, J.J.4    Ye, L.P.5    Wang, L.Y.6
  • 234
    • 41649090153 scopus 로고    scopus 로고
    • Curcumin (diferuloylmethane) alters the expression profiles of microRNAs in human pancreatic cancer cells
    • [234] Sun, M., Estrov, Z., Ji, Y., Coombes, K.R., Harris, D.H., Kurzrock, R., et al. Curcumin (diferuloylmethane) alters the expression profiles of microRNAs in human pancreatic cancer cells. Mol. Cancer Ther. 7 (2008), 464–473.
    • (2008) Mol. Cancer Ther. , vol.7 , pp. 464-473
    • Sun, M.1    Estrov, Z.2    Ji, Y.3    Coombes, K.R.4    Harris, D.H.5    Kurzrock, R.6
  • 235
    • 73949133652 scopus 로고    scopus 로고
    • Epigallocatechin gallate up-regulation of miR-16 and induction of apoptosis in human cancer cells
    • [235] Tsang, W.P., Kwok, T.T., Epigallocatechin gallate up-regulation of miR-16 and induction of apoptosis in human cancer cells. J. Nutr. Biochem. 21 (2010), 140–146.
    • (2010) J. Nutr. Biochem. , vol.21 , pp. 140-146
    • Tsang, W.P.1    Kwok, T.T.2
  • 236
    • 84870174953 scopus 로고    scopus 로고
    • Curcumin and synthetic analogs induce reactive oxygen species and decreases specificity protein (Sp) transcription factors by targeting microRNAs
    • [236] Gandhy, S.U., Kim, K., Larsen, L., Rosengren, R.J., Safe, S., Curcumin and synthetic analogs induce reactive oxygen species and decreases specificity protein (Sp) transcription factors by targeting microRNAs. BMC Cancer, 12, 2012, 564.
    • (2012) BMC Cancer , vol.12 , pp. 564
    • Gandhy, S.U.1    Kim, K.2    Larsen, L.3    Rosengren, R.J.4    Safe, S.5
  • 237
    • 84857145850 scopus 로고    scopus 로고
    • 3,3′-Diindolylmethane inhibits breast cancer cell growth via miR-21-mediated Cdc25A degradation
    • [237] Jin, Y., 3,3′-Diindolylmethane inhibits breast cancer cell growth via miR-21-mediated Cdc25A degradation. Mol. Cell Biochem. 358 (2011), 345–354.
    • (2011) Mol. Cell Biochem. , vol.358 , pp. 345-354
    • Jin, Y.1
  • 238
    • 84863050461 scopus 로고    scopus 로고
    • Epigenetic silencing of miR-34a in human prostate cancer cells and tumor tissue specimens can be reversed by BR-DIM treatment
    • [238] Kong, D., Heath, E., Chen, W., Cher, M., Powell, I., Heilbrun, L., et al. Epigenetic silencing of miR-34a in human prostate cancer cells and tumor tissue specimens can be reversed by BR-DIM treatment. Am. J. Transl. Res. 4 (2012), 14–23.
    • (2012) Am. J. Transl. Res. , vol.4 , pp. 14-23
    • Kong, D.1    Heath, E.2    Chen, W.3    Cher, M.4    Powell, I.5    Heilbrun, L.6
  • 239
    • 77649196575 scopus 로고    scopus 로고
    • Alteration of microRNA expression in vinyl carbamate-induced mouse lung tumors and modulation by the chemopreventive agent indole-3-carbinol
    • [239] Melkamu, T., Zhang, X., Tan, J., Zeng, Y., Kassie, F., Alteration of microRNA expression in vinyl carbamate-induced mouse lung tumors and modulation by the chemopreventive agent indole-3-carbinol. Carcinogenesis 31 (2010), 252–258.
    • (2010) Carcinogenesis , vol.31 , pp. 252-258
    • Melkamu, T.1    Zhang, X.2    Tan, J.3    Zeng, Y.4    Kassie, F.5
  • 240
    • 84867931323 scopus 로고    scopus 로고
    • Lycopene inhibits hepatic steatosis via microRNA-21-induced downregulation of fatty acid-binding protein 7 in mice fed a high-fat diet
    • [240] Ahn, J., Lee, H., Jung, C.H., Ha, T., Lycopene inhibits hepatic steatosis via microRNA-21-induced downregulation of fatty acid-binding protein 7 in mice fed a high-fat diet. Mol. Nutr. Food Res. 56 (2012), 1665–1674.
    • (2012) Mol. Nutr. Food Res. , vol.56 , pp. 1665-1674
    • Ahn, J.1    Lee, H.2    Jung, C.H.3    Ha, T.4
  • 241
    • 84878244435 scopus 로고    scopus 로고
    • Organosulfur garlic compounds induce neovasculogenesis in human endothelial progenitor cells through a modulation of MicroRNA 221 and the PI3-K/Akt signaling pathways
    • [241] Chiang, E.P., Chiu, S.C., Pai, M.H., Wang, Y.C., Wang, F.Y., Kuo, Y.H., et al. Organosulfur garlic compounds induce neovasculogenesis in human endothelial progenitor cells through a modulation of MicroRNA 221 and the PI3-K/Akt signaling pathways. J. Agric. Food Chem. 61 (2013), 4839–4849.
    • (2013) J. Agric. Food Chem. , vol.61 , pp. 4839-4849
    • Chiang, E.P.1    Chiu, S.C.2    Pai, M.H.3    Wang, Y.C.4    Wang, F.Y.5    Kuo, Y.H.6
  • 242
    • 84911910268 scopus 로고    scopus 로고
    • Diallyl disulfide suppresses SRC/Ras/ERK signaling-mediated proliferation and metastasis in human breast cancer by up-regulating miR-34a
    • [242] Xiao, X., Chen, B., Liu, X., Liu, P., Zheng, G., Ye, F., et al. Diallyl disulfide suppresses SRC/Ras/ERK signaling-mediated proliferation and metastasis in human breast cancer by up-regulating miR-34a. PLoS One, 9, 2014, e112720.
    • (2014) PLoS One , vol.9 , pp. e112720
    • Xiao, X.1    Chen, B.2    Liu, X.3    Liu, P.4    Zheng, G.5    Ye, F.6
  • 243
    • 79961064507 scopus 로고    scopus 로고
    • Resveratrol and prostate cancer: promising role for microRNAs
    • [243] Dhar, S., Hicks, C., Levenson, A.S., Resveratrol and prostate cancer: promising role for microRNAs. Mol. Nutr. Food Res. 55 (2011), 1219–1229.
    • (2011) Mol. Nutr. Food Res. , vol.55 , pp. 1219-1229
    • Dhar, S.1    Hicks, C.2    Levenson, A.S.3
  • 244
    • 84871318501 scopus 로고    scopus 로고
    • Resveratrol reduces prostate cancer growth and metastasis by inhibiting the Akt/MicroRNA-21 pathway
    • [244] Sheth, S., Jajoo, S., Kaur, T., Mukherjea, D., Sheehan, K., Rybak, L.P., et al. Resveratrol reduces prostate cancer growth and metastasis by inhibiting the Akt/MicroRNA-21 pathway. PLoS One, 7, 2012, e51655.
    • (2012) PLoS One , vol.7 , pp. e51655
    • Sheth, S.1    Jajoo, S.2    Kaur, T.3    Mukherjea, D.4    Sheehan, K.5    Rybak, L.P.6
  • 245
    • 77957721534 scopus 로고    scopus 로고
    • Resveratrol modulates the levels of microRNAs targeting genes encoding tumor-suppressors and effectors of TGFbeta signaling pathway in SW480 cells
    • [245] Tili, E., Michaille, J.J., Alder, H., Volinia, S., Delmas, D., Latruffe, N., Croce, C.M., Resveratrol modulates the levels of microRNAs targeting genes encoding tumor-suppressors and effectors of TGFbeta signaling pathway in SW480 cells. Biochem. Pharmacol. 80 (2010), 2057–2065.
    • (2010) Biochem. Pharmacol. , vol.80 , pp. 2057-2065
    • Tili, E.1    Michaille, J.J.2    Alder, H.3    Volinia, S.4    Delmas, D.5    Latruffe, N.6    Croce, C.M.7
  • 246
    • 84903542436 scopus 로고    scopus 로고
    • Gefitinib and luteolin cause growth arrest of human prostate cancer PC-3 cells via inhibition of cyclin G-associated kinase and induction of miR-630
    • [246] Sakurai, M.A., Ozaki, Y., Okuzaki, D., Naito, Y., Sasakura, T., Okamoto, A., et al. Gefitinib and luteolin cause growth arrest of human prostate cancer PC-3 cells via inhibition of cyclin G-associated kinase and induction of miR-630. PLoS One, 9, 2014, e100124.
    • (2014) PLoS One , vol.9 , pp. e100124
    • Sakurai, M.A.1    Ozaki, Y.2    Okuzaki, D.3    Naito, Y.4    Sasakura, T.5    Okamoto, A.6
  • 247
    • 84947728723 scopus 로고    scopus 로고
    • Luteolin induces apoptosis by up-regulating miR-34a in human gastric cancer cells
    • [247] Wu, H., Huang, M., Liu, Y., Shu, Y., Liu, P., Luteolin induces apoptosis by up-regulating miR-34a in human gastric cancer cells. Technol. Cancer Res. Treat. 14 (2015), 747–755.
    • (2015) Technol. Cancer Res. Treat. , vol.14 , pp. 747-755
    • Wu, H.1    Huang, M.2    Liu, Y.3    Shu, Y.4    Liu, P.5
  • 248
    • 84865503446 scopus 로고    scopus 로고
    • miR-141modulates androgen receptor transcriptional activity in human prostate cancer cells through targeting the small heterodimer partner protein
    • [248] Xiao, J., Gong, A.Y., Eischeid, A.N., Chen, D., Deng, C., Young, C.Y., et al. miR-141modulates androgen receptor transcriptional activity in human prostate cancer cells through targeting the small heterodimer partner protein. Prostate 72 (2012), 1514–1522.
    • (2012) Prostate , vol.72 , pp. 1514-1522
    • Xiao, J.1    Gong, A.Y.2    Eischeid, A.N.3    Chen, D.4    Deng, C.5    Young, C.Y.6
  • 249
    • 77953425009 scopus 로고    scopus 로고
    • Combined inhibitory effects of soy isoflavones and curcumin on the production of prostate-specific antigen
    • [249] Ide, H., Tokiwa, S., Sakamaki, K., Nishio, K., Isotani, S., Muto, S., et al. Combined inhibitory effects of soy isoflavones and curcumin on the production of prostate-specific antigen. Prostate 70 (2010), 1127–1133.
    • (2010) Prostate , vol.70 , pp. 1127-1133
    • Ide, H.1    Tokiwa, S.2    Sakamaki, K.3    Nishio, K.4    Isotani, S.5    Muto, S.6
  • 250
    • 0034772953 scopus 로고    scopus 로고
    • Pharmacodynamic and pharmacokinetic study of oral Curcuma extract in patients with colorectal cancer
    • [250] Sharma, R.A., McLelland, H.R., Hill, K.A., Ireson, C.R., Euden, S.A., Manson, M.M., et al. Pharmacodynamic and pharmacokinetic study of oral Curcuma extract in patients with colorectal cancer. Clin. Cancer Res. 7 (2001), 1894–1900.
    • (2001) Clin. Cancer Res. , vol.7 , pp. 1894-1900
    • Sharma, R.A.1    McLelland, H.R.2    Hill, K.A.3    Ireson, C.R.4    Euden, S.A.5    Manson, M.M.6
  • 251
    • 70549097006 scopus 로고    scopus 로고
    • Green tea polyphenols for prostate cancer chemoprevention: a translational perspective
    • [251] Johnson, J.J., Bailey, H.H., Mukhtar, H., Green tea polyphenols for prostate cancer chemoprevention: a translational perspective. Phytomedicine 17 (2010), 3–13.
    • (2010) Phytomedicine , vol.17 , pp. 3-13
    • Johnson, J.J.1    Bailey, H.H.2    Mukhtar, H.3
  • 252
    • 84857681419 scopus 로고    scopus 로고
    • Randomized, double-blind, placebo-controlled trial of polyphenon E in prostate cancer patients before prostatectomy: evaluation of potential chemopreventive activities
    • [252] Nguyen, M.M., Ahmann, F.R., Nagle, R.B., Hsu, C.H., Tangrea, J.A., Parnes, H.L., et al. Randomized, double-blind, placebo-controlled trial of polyphenon E in prostate cancer patients before prostatectomy: evaluation of potential chemopreventive activities. Cancer Prev. Res. 5 (2012), 290–298.
    • (2012) Cancer Prev. Res. , vol.5 , pp. 290-298
    • Nguyen, M.M.1    Ahmann, F.R.2    Nagle, R.B.3    Hsu, C.H.4    Tangrea, J.A.5    Parnes, H.L.6
  • 253
    • 84871571920 scopus 로고    scopus 로고
    • The effects of short-term genistein intervention on prostate biomarker expression in patients with localised prostate cancer before radical prostatectomy
    • [253] Lazarevic, B., Hammarstrom, C., Yang, J., Ramberg, H., Diep, L.M., Karlsen, S.J., et al. The effects of short-term genistein intervention on prostate biomarker expression in patients with localised prostate cancer before radical prostatectomy. Br. J. Nutr. 108 (2012), 2138–2147.
    • (2012) Br. J. Nutr. , vol.108 , pp. 2138-2147
    • Lazarevic, B.1    Hammarstrom, C.2    Yang, J.3    Ramberg, H.4    Diep, L.M.5    Karlsen, S.J.6
  • 254
    • 84855481687 scopus 로고    scopus 로고
    • Prostate cancer chemoprevention study: an investigative randomized control study using purified isoflavones in men with rising prostate-specific antigen
    • [254] Miyanaga, N., Akaza, H., Hinotsu, S., Fujioka, T., Naito, S., Namiki, M., et al. Prostate cancer chemoprevention study: an investigative randomized control study using purified isoflavones in men with rising prostate-specific antigen. Cancer Sci. 103 (2012), 125–130.
    • (2012) Cancer Sci. , vol.103 , pp. 125-130
    • Miyanaga, N.1    Akaza, H.2    Hinotsu, S.3    Fujioka, T.4    Naito, S.5    Namiki, M.6
  • 255
    • 77957372039 scopus 로고    scopus 로고
    • A phase I dose-escalation study of oral BR-DIM in castrate-resistant, non-metastatic prostate cancer
    • [255] Heath, E.I., Heilbrun, L.K., Li, J., Vaishampayan, U., Harper, F., Pemberton, P., et al. A phase I dose-escalation study of oral BR-DIM in castrate-resistant, non-metastatic prostate cancer. Am. J. Transl. Res. 2 (2010), 402–411.
    • (2010) Am. J. Transl. Res. , vol.2 , pp. 402-411
    • Heath, E.I.1    Heilbrun, L.K.2    Li, J.3    Vaishampayan, U.4    Harper, F.5    Pemberton, P.6
  • 256
    • 84892873378 scopus 로고    scopus 로고
    • Low prostate concentration of lycopene is associated with development of prostate cancer in patients with high-grade prostatic intraepithelial neoplasia
    • [256] Mariani, S., Lionetto, L., Cavallari, M., Tubaro, A., Rasio, D., De Nunzio, C., et al. Low prostate concentration of lycopene is associated with development of prostate cancer in patients with high-grade prostatic intraepithelial neoplasia. Int. J. Mol. Sci. 15 (2014), 1433–1440.
    • (2014) Int. J. Mol. Sci. , vol.15 , pp. 1433-1440
    • Mariani, S.1    Lionetto, L.2    Cavallari, M.3    Tubaro, A.4    Rasio, D.5    De Nunzio, C.6
  • 257
    • 0037248470 scopus 로고    scopus 로고
    • Absorption of three wine-related polyphenols in three different matrices by healthy subjects
    • [257] Goldberg, D.M., Yan, J., Soleas, G.J., Absorption of three wine-related polyphenols in three different matrices by healthy subjects. Clin. Biochem. 36 (2003), 79–87.
    • (2003) Clin. Biochem. , vol.36 , pp. 79-87
    • Goldberg, D.M.1    Yan, J.2    Soleas, G.J.3
  • 258
    • 84939538926 scopus 로고    scopus 로고
    • A phase II study of sulforaphane-rich broccoli sprout extracts in men with recurrent prostate cancer
    • [258] Alumkal, J.J., Slottke, R., Schwartzman, J., Cherala, G., Munar, M., Graff, J.N., et al. A phase II study of sulforaphane-rich broccoli sprout extracts in men with recurrent prostate cancer. Investig. New Drugs 33 (2015), 480–489.
    • (2015) Investig. New Drugs , vol.33 , pp. 480-489
    • Alumkal, J.J.1    Slottke, R.2    Schwartzman, J.3    Cherala, G.4    Munar, M.5    Graff, J.N.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.