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Volumn 21, Issue 4, 2011, Pages 353-361

Epigenetic priming of the metabolic syndrome

Author keywords

circadian; development; epigenetics; maternal diet; metabolic syndrome

Indexed keywords

ANGIOTENSIN 1B RECEPTOR; BASIC HELIX LOOP HELIX TRANSCRIPTION FACTOR; CRYPTOCHROME 1; CRYPTOCHROME 2; DNA METHYLTRANSFERASE 1; FOLIC ACID; GLUCOCORTICOID RECEPTOR; HISTONE; HISTONE ACETYLTRANSFERASE; HISTONE H3; HISTONE H4; INSULIN RECEPTOR; LYSINE; MICRORNA; NICOTINAMIDE ADENINE DINUCLEOTIDE; PER1 PROTEIN; PER2 PROTEIN; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR ALPHA; PROTEIN BMAL1; PROTEIN P16; SATURATED FATTY ACID; SIRTUIN 1; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR CLOCK; TRANSCRIPTION FACTOR PDX 1;

EID: 79954533286     PISSN: 15376516     EISSN: 15376524     Source Type: Journal    
DOI: 10.3109/15376516.2011.559370     Document Type: Review
Times cited : (45)

References (58)
  • 1
    • 51349085004 scopus 로고    scopus 로고
    • Developmental origins of disease and determinants of chromatin structure: Maternal diet modifies the primate fetal epigenome
    • Aagaard-Tillery KM, Grove K, Bishop J, Ke X, Fu Q, McKnight R, Lane RH. 2008. Developmental origins of disease and determinants of chromatin structure: maternal diet modifies the primate fetal epigenome. J Mol Endocrinol 41:91-102.
    • (2008) J Mol Endocrinol , vol.41 , pp. 91-102
    • Aagaard-Tillery, K.M.1    Grove, K.2    Bishop, J.3    Ke, X.4    Fu, Q.5    McKnight, R.6    Lane, R.H.7
  • 2
    • 79954525059 scopus 로고    scopus 로고
    • Pathways linking the early environment to long-term health and lifespan
    • Epub ahead of print
    • Barnes SK, Ozanne SE. 2010. Pathways linking the early environment to long-term health and lifespan. Prog Biophys Mol Biol Epub ahead of print.
    • (2010) Prog Biophys Mol Biol
    • Barnes, S.K.1    Ozanne, S.E.2
  • 3
    • 77949500501 scopus 로고    scopus 로고
    • Glucocorticoid effects on the programming of AT1b angiotensin receptor gene methylation and expression in the rat
    • Bogdarina I, Haase A, Langley-Evans S, Clark AJ. 2010. Glucocorticoid effects on the programming of AT1b angiotensin receptor gene methylation and expression in the rat. PLoS ONE 5:e9237.
    • (2010) PLoS ONE , vol.5
    • Bogdarina, I.1    Haase, A.2    Langley-Evans, S.3    Clark, A.J.4
  • 4
    • 78049402859 scopus 로고    scopus 로고
    • Molecular signals of epigenetic states
    • Bonasio R, Tu S, Reinberg D. 2010. Molecular signals of epigenetic states. Science 330:612-616.
    • (2010) Science , vol.330 , pp. 612-616
    • Bonasio, R.1    Tu, S.2    Reinberg, D.3
  • 5
    • 73249128357 scopus 로고    scopus 로고
    • The metabolic syndrome: Common origins of a multifactorial disorder
    • Bruce KD, Byrne CD. 2009. The metabolic syndrome: common origins of a multifactorial disorder. Postgrad Med J 85:614-621.
    • (2009) Postgrad Med J , vol.85 , pp. 614-621
    • Bruce, K.D.1    Byrne, C.D.2
  • 7
    • 77249117213 scopus 로고    scopus 로고
    • The developmental origins, mechanisms, and implications of metabolic syndrome
    • Bruce KD, Hanson MA. 2010. The developmental origins, mechanisms, and implications of metabolic syndrome. J Nutr 140:648-652.
    • (2010) J Nutr , vol.140 , pp. 648-652
    • Bruce, K.D.1    Hanson, M.A.2
  • 8
    • 66749093541 scopus 로고    scopus 로고
    • Folic acid supplementation during the juvenilepubertal period in rats modifies the phenotype and epigenotype induced by prenatal nutrition
    • Burdge GC, Lillycrop KA, Phillips ES, Slater-Jefferies JL, Jackson AA, Hanson MA. 2009. Folic acid supplementation during the juvenilepubertal period in rats modifies the phenotype and epigenotype induced by prenatal nutrition. J Nutr 139:1054-1060.
    • (2009) J Nutr , vol.139 , pp. 1054-1060
    • Burdge, G.C.1    Lillycrop, K.A.2    Phillips, E.S.3    Slater-Jefferies, J.L.4    Jackson, A.A.5    Hanson, M.A.6
  • 10
    • 78651431131 scopus 로고    scopus 로고
    • Developmental origins of the metabolic syndrome: Body clocks and stress responses
    • Cagampang FR, Poore KR, Hanson MA. 2011. Developmental origins of the metabolic syndrome: body clocks and stress responses. Brain Behav Immun 25:214-220.
    • (2011) Brain Behav Immun , vol.25 , pp. 214-220
    • Cagampang, F.R.1    Poore, K.R.2    Hanson, M.A.3
  • 11
  • 12
    • 77956206292 scopus 로고    scopus 로고
    • Obesity, insulin resistance, and pregnancy outcome
    • Catalano PM. 2010. Obesity, insulin resistance, and pregnancy outcome. Reproduction 140:365-371.
    • (2010) Reproduction , vol.140 , pp. 365-371
    • Catalano, P.M.1
  • 14
    • 70350313230 scopus 로고    scopus 로고
    • Maternal high-fat diet promotes body length increases and insulin insensitivity in second-generation mice
    • Dunn GA, Bale TL. 2009. Maternal high-fat diet promotes body length increases and insulin insensitivity in second-generation mice. Endocrinology 150:4999-5009.
    • (2009) Endocrinology , vol.150 , pp. 4999-5009
    • Dunn, G.A.1    Bale, T.L.2
  • 15
    • 23644445520 scopus 로고    scopus 로고
    • Prenatal protein malnutrition induces a phase shift advance of the spontaneous locomotor rhythm and alters the rest/activity ratio in adults rats
    • DOI 10.1080/10284150400026117
    • Durán P, Cintra L, Galler JR, Tonkiss J. 2005. Prenatal protein malnutrition induces a phase shift advance of the spontaneous locomotor rhythm and alters the rest/activity ratio in adult rats. Nutr Neurosci 8:167-172. (Pubitemid 41131433)
    • (2005) Nutritional Neuroscience , vol.8 , Issue.3 , pp. 167-172
    • Duran, P.1    Cintra, L.2    Galler, J.R.3    Tonkiss, J.4
  • 16
    • 70149105226 scopus 로고    scopus 로고
    • Long-term maternal high-fat feeding from weaning through pregnancy and lactation predisposes offspring to hypertension, raised plasma lipids and fatty liver in mice
    • Elahi MM, Cagampang FR, Mukhtar D, Anthony FW, Ohri SK, Hanson MA. 2009. Long-term maternal high-fat feeding from weaning through pregnancy and lactation predisposes offspring to hypertension, raised plasma lipids and fatty liver in mice. Br J Nutr 102:514-519.
    • (2009) Br J Nutr , vol.102 , pp. 514-519
    • Elahi, M.M.1    Cagampang, F.R.2    Mukhtar, D.3    Anthony, F.W.4    Ohri, S.K.5    Hanson, M.A.6
  • 17
    • 0037426839 scopus 로고    scopus 로고
    • Rhythmic histone acetylation underlies transcription in the mammalian circadian clock
    • DOI 10.1038/nature01314
    • Etchegaray JP, Lee C, Wade PA, Reppert SM. 2003. Rhythmic histone acetylation underlies transcription in the mammalian circadian clock. Nature 421:177-182. (Pubitemid 36090986)
    • (2003) Nature , vol.421 , Issue.6919 , pp. 177-182
    • Etchegaray, J.-P.1    Lee, C.2    Wade, P.A.3    Reppert, S.M.4
  • 19
    • 78650883004 scopus 로고    scopus 로고
    • The circadian clock and metabolism
    • Froy O. 2011. The circadian clock and metabolism. Clin Sci 120:65-72.
    • (2011) Clin Sci , vol.120 , pp. 65-72
    • Froy, O.1
  • 20
    • 34247106694 scopus 로고    scopus 로고
    • Developmental plasticity and human disease: Research directions
    • DOI 10.1111/j.1365-2796.2007.01802.x
    • Gluckman PD, Hanson MA. 2007. Developmental plasticity and human disease: research directions. J Intern Med 261:461-471. (Pubitemid 46587728)
    • (2007) Journal of Internal Medicine , vol.261 , Issue.5 , pp. 461-471
    • Gluckman, P.D.1    Hanson, M.A.2
  • 21
    • 33847367675 scopus 로고    scopus 로고
    • Non-genomic transgenerational inheritance of disease risk
    • DOI 10.1002/bies.20522
    • Gluckman PD, Hanson MA, Beedle AS. 2007. Non-genomic transgenerational inheritance of disease risk. Bioessays 29:145-154. (Pubitemid 46340249)
    • (2007) BioEssays , vol.29 , Issue.2 , pp. 145-154
    • Gluckman, P.D.1    Hanson, M.A.2    Beedle, A.S.3
  • 22
    • 0032104680 scopus 로고    scopus 로고
    • Maternal regulation of fetal development and health in adult life
    • DOI 10.1016/S0301-2115(98)00060-8, PII S0301211598000608
    • Godfrey KM. 1998. Maternal regulation of fetal development and health in adult life. Eur J Obstet Gynecol Reprod Biol 78:141-150. (Pubitemid 28201104)
    • (1998) European Journal of Obstetrics Gynecology and Reproductive Biology , vol.78 , Issue.2 , pp. 141-150
    • Godfrey, K.M.1
  • 24
    • 33645754517 scopus 로고    scopus 로고
    • Metabolic syndrome: Therapeutic considerations
    • Grundy SM. 2005. Metabolic syndrome: therapeutic considerations. Handb Exp Pharmacol 107-133.
    • (2005) Handb Exp Pharmacol , pp. 107-133
    • Grundy, S.M.1
  • 25
    • 0026772772 scopus 로고
    • Type 2 (non-insulin-dependent) diabetes mellitus: The thrifty phenotype hypothesis
    • Hales CN, Barker DJ. 1992. Type 2 (non-insulin-dependent) diabetes mellitus: the thrifty phenotype hypothesis. Diabetologia 35:595-601.
    • (1992) Diabetologia , vol.35 , pp. 595-601
    • Hales, C.N.1    Barker, D.J.2
  • 27
    • 43449133625 scopus 로고    scopus 로고
    • The metabolic syndrome and male infertility
    • DOI 10.2164/jandrol.107.003731
    • Kasturi SS, Tannir J, Brannigan RE. 2008. The metabolic syndrome and male infertility. J Androl 29:251-259. (Pubitemid 351669015)
    • (2008) Journal of Andrology , vol.29 , Issue.3 , pp. 251-259
    • Kasturi, S.S.1    Tannir, J.2    Brannigan, R.E.3
  • 28
    • 33750133607 scopus 로고    scopus 로고
    • Maternal obesity, metabolism, and pregnancy outcomes
    • King JC. 2006. Maternal obesity, metabolism, and pregnancy outcomes. Annu Rev Nutr 26:271-291.
    • (2006) Annu Rev Nutr , vol.26 , pp. 271-291
    • King, J.C.1
  • 29
    • 33749031807 scopus 로고    scopus 로고
    • Molecular components of the mammalian circadian clock
    • DOI 10.1093/hmg/ddl207
    • Ko CH, Takahashi JS. 2006. Molecular components of the mammalian circadian clock. Hum Mol Genet 15 Spec No 2:R271-R277. (Pubitemid 44446803)
    • (2006) Human Molecular Genetics , vol.15 , Issue.SUPPL. 2
    • Ko, C.H.1    Takahashi, J.S.2
  • 30
    • 73449110929 scopus 로고    scopus 로고
    • Inter-individual variation of dietary fat-induced mesoderm specific transcript in adipose tissue within inbred mice is not caused by altered promoter methylation
    • Koza RA, Rogers P, Kozak LP. 2009. Inter-individual variation of dietary fat-induced mesoderm specific transcript in adipose tissue within inbred mice is not caused by altered promoter methylation. Epigenetics 4:512-518.
    • (2009) Epigenetics , vol.4 , pp. 512-518
    • Koza, R.A.1    Rogers, P.2    Kozak, L.P.3
  • 31
    • 0034992684 scopus 로고    scopus 로고
    • A daily rhythm in glucose tolerance: A role for the suprachiasmatic nucleus
    • la Fleur SE, Kalsbeek A, Wortel J, Fekkes ML, Buijs RM. 2001. A daily rhythm in glucose tolerance: a role for the suprachiasmatic nucleus. Diabetes 50:1237-1243. (Pubitemid 32500154)
    • (2001) Diabetes , vol.50 , Issue.6 , pp. 1237-1243
    • La Fleur, S.E.1    Kalsbeek, A.2    Wortel, J.3    Fekkes, M.L.4    Buijs, R.M.5
  • 33
    • 20444411948 scopus 로고    scopus 로고
    • Dietary protein restriction of pregnant rats induces and folic acid supplementation prevents epigenetic modification of hepatic gene expression in the offspring
    • Lillycrop KA, Phillips ES, Jackson AA, Hanson MA, Burdge GC. 2005. Dietary protein restriction of pregnant rats induces and folic acid supplementation prevents epigenetic modification of hepatic gene expression in the offspring. J Nutr 135:1382-1386. (Pubitemid 40799599)
    • (2005) Journal of Nutrition , vol.135 , Issue.6 , pp. 1382-1386
    • Lillycrop, K.A.1    Phillips, E.S.2    Jackson, A.A.3    Hanson, M.A.4    Burdge, G.C.5
  • 34
    • 34247514180 scopus 로고    scopus 로고
    • Induction of altered epigenetic regulation of the hepatic glucocorticoid receptor in the offspring of rats fed a protein-restricted diet during pregnancy suggests that reduced DNA methyltransferase-1 expression is involved in impaired DNA methylation and changes in histone modifications
    • DOI 10.1017/S000711450769196X, PII S000711450769196X
    • Lillycrop KA, Slater-Jefferies JL, Hanson MA, Godfrey KM, Jackson AA, Burdge GC. 2007. Induction of altered epigenetic regulation of the hepatic glucocorticoid receptor in the offspring of rats fed a protein-restricted diet during pregnancy suggests that reduced DNA methyltransferase-1 expression is involved in impaired DNA methylation and changes in histone modifications. Br J Nutr 97:1064-1073. (Pubitemid 46925358)
    • (2007) British Journal of Nutrition , vol.97 , Issue.6 , pp. 1064-1073
    • Lillycrop, K.A.1    Slater-Jefferies, J.L.2    Hanson, M.A.3    Godfrey, K.M.4    Jackson, A.A.5    Burdge, G.C.6
  • 35
    • 77955635459 scopus 로고    scopus 로고
    • Maternal dietary choline deficiency alters angiogenesis in fetal mouse hippocampus
    • Mehedint MG, Craciunescu CN, Zeisel SH. 2010. Maternal dietary choline deficiency alters angiogenesis in fetal mouse hippocampus. Proc Natl Acad Sci USA 107:12834-12839.
    • (2010) Proc Natl Acad Sci USA , vol.107 , pp. 12834-12839
    • Mehedint, M.G.1    Craciunescu, C.N.2    Zeisel, S.H.3
  • 36
    • 47549088250 scopus 로고    scopus 로고
    • +-Dependent Deacetylase SIRT1 Modulates CLOCK-Mediated Chromatin Remodeling and Circadian Control
    • DOI 10.1016/j.cell.2008.07.002, PII S0092867408008799
    • Nakahata Y, Kaluzova M, Grimaldi B, Sahar S, Hirayama J, Chen D, Guarente LP, Sassone-Corsi P. 2008. The NAD+-dependent deacetylase SIRT1 modulates CLOCK-mediated chromatin remodeling and circadian control. Cell 134:329-340. (Pubitemid 352010336)
    • (2008) Cell , vol.134 , Issue.2 , pp. 329-340
    • Nakahata, Y.1    Kaluzova, M.2    Grimaldi, B.3    Sahar, S.4    Hirayama, J.5    Chen, D.6    Guarente, L.P.7    Sassone-Corsi, P.8
  • 37
    • 0033539313 scopus 로고    scopus 로고
    • Influence of maternal hypercholesterolaemia during pregnancy on progression of early atherosclerotic lesions in childhood: Fate of Early Lesions in Children (FELIC) study
    • DOI 10.1016/S0140-6736(99)02131-5
    • Napoli C, Glass CK, Witztum JL, Deutsch R, D'Armiento FP, Palinski W. 1999. Influence of maternal hypercholesterolaemia during pregnancy on progression of early atherosclerotic lesions in childhood: Fate of Early Lesions in Children (FELIC) study. Lancet 354:1234-1241. (Pubitemid 29469351)
    • (1999) Lancet , vol.354 , Issue.9186 , pp. 1234-1241
    • Napoli, C.1    Glass, C.K.2    Witztum, J.L.3    Deutsch, R.4    D'Armiento, F.P.5    Palinski, W.6
  • 38
    • 77958596171 scopus 로고    scopus 로고
    • Chronic high-fat diet in fathers programs̊-cell dysfunction in female rat offspring
    • Ng SF, Lin RC, Laybutt DR, Barres R, Owens JA, Morris MJ. 2010. Chronic high-fat diet in fathers programs̊-cell dysfunction in female rat offspring. Nature 467:963-966.
    • (2010) Nature , vol.467 , pp. 963-966
    • Ng, S.F.1    Lin, R.C.2    Laybutt, D.R.3    Barres, R.4    Owens, J.A.5    Morris, M.J.6
  • 39
    • 45549097738 scopus 로고    scopus 로고
    • Development of type 2 diabetes following intrauterine growth retardation in rats is associated with progressive epigenetic silencing of Pdx1
    • DOI 10.1172/JCI33655
    • Park JH, Stoffers DA, Nicholls RD, Simmons RA. 2008. Development of type 2 diabetes following intrauterine growth retardation in rats is associated with progressive epigenetic silencing of Pdx1. J Clin Invest 118:2316-2324. (Pubitemid 351872348)
    • (2008) Journal of Clinical Investigation , vol.118 , Issue.6 , pp. 2316-2324
    • Park, J.H.1    Stoffers, D.A.2    Nicholls, R.D.3    Simmons, R.A.4
  • 40
    • 0037194790 scopus 로고    scopus 로고
    • Coordination of circadian timing in mammals
    • DOI 10.1038/nature00965
    • Reppert SM, Weaver DR. 2002. Coordination of circadian timing in mammals. Nature 418:935-941. (Pubitemid 34976023)
    • (2002) Nature , vol.418 , Issue.6901 , pp. 935-941
    • Reppert, S.M.1    Weaver, D.R.2
  • 42
    • 0035997367 scopus 로고    scopus 로고
    • Metabolism and the control of circadian rhythms
    • DOI 10.1146/annurev.biochem.71.090501.142857
    • Rutter J, Reick M, McKnight SL. 2002. Metabolism and the control of circadian rhythms. Annu Rev Biochem 71:307-331. (Pubitemid 34800223)
    • (2002) Annual Review of Biochemistry , vol.71 , pp. 307-331
    • Rutter, J.1    Reick, M.2    McKnight, S.L.3
  • 44
    • 0037184977 scopus 로고    scopus 로고
    • A web of circadian pacemakers
    • DOI 10.1016/S0092-8674(02)01225-4
    • Schibler U, Sassone-Corsi P. 2002. A web of circadian pacemakers. Cell 111:919-922. (Pubitemid 36044683)
    • (2002) Cell , vol.111 , Issue.7 , pp. 919-922
    • Schibler, U.1    Sassone-Corsi, P.2
  • 47
    • 75249101597 scopus 로고    scopus 로고
    • Time trends in childhood and adolescent obesity in England from 1995 to 2007 and projections of prevalence to 2015
    • Stamatakis E, Zaninotto P, Falaschetti E, Mindell J, Head J. 2010. Time trends in childhood and adolescent obesity in England from 1995 to 2007 and projections of prevalence to 2015. J Epidemiol Community Health 64:167-174.
    • (2010) J Epidemiol Community Health , vol.64 , pp. 167-174
    • Stamatakis, E.1    Zaninotto, P.2    Falaschetti, E.3    Mindell, J.4    Head, J.5
  • 48
    • 0037341252 scopus 로고    scopus 로고
    • Neonatal exendin-4 prevents the development of diabetes in the intrauterine growth retarded rat
    • DOI 10.2337/diabetes.52.3.734
    • Stoffers DA, Desai BM, DeLeon DD, Simmons RA. 2003. Neonatal exendin-4 prevents the development of diabetes in the intrauterine growth retarded rat. Diabetes 52:734-740. (Pubitemid 36323581)
    • (2003) Diabetes , vol.52 , Issue.3 , pp. 734-740
    • Stoffers, D.A.1    Desai, B.M.2    DeLeon, D.D.3    Simmons, R.A.4
  • 49
    • 79551627622 scopus 로고    scopus 로고
    • Epigenomics: Maternal high-fat diet exposure in utero disrupts peripheral circadian gene expression in nonhuman primates
    • Suter M, Bocock P, Showalter L, Hu M, Shope C, McKnight R, Grove K, Lane R, Aagaard-Tillery K. 2011. Epigenomics: maternal high-fat diet exposure in utero disrupts peripheral circadian gene expression in nonhuman primates. FASEB J 25: 714-726.
    • (2011) FASEB J , vol.25 , pp. 714-726
    • Suter, M.1    Bocock, P.2    Showalter, L.3    Hu, M.4    Shope, C.5    McKnight, R.6    Grove, K.7    Lane, R.8    Aagaard-Tillery, K.9
  • 53
    • 77957258099 scopus 로고    scopus 로고
    • Maternal high-fat diet alters methylation and gene expression of dopamine and opioid-related genes
    • Vucetic Z, Kimmel J, Totoki K, Hollenbeck E, Reyes TM. 2010. Maternal high-fat diet alters methylation and gene expression of dopamine and opioid-related genes. Endocrinology 151:4756-4764.
    • (2010) Endocrinology , vol.151 , pp. 4756-4764
    • Vucetic, Z.1    Kimmel, J.2    Totoki, K.3    Hollenbeck, E.4    Reyes, T.M.5
  • 56
    • 33747157406 scopus 로고    scopus 로고
    • Nuclear Receptor Expression Links the Circadian Clock to Metabolism
    • DOI 10.1016/j.cell.2006.06.050, PII S0092867406009780
    • Yang X, Downes M, Yu RT, Bookout AL, He W, Straume M, Mangelsdorf DJ, Evans RM. 2006. Nuclear receptor expression links the circadian clock to metabolism. Cell 126:801-810. (Pubitemid 44233631)
    • (2006) Cell , vol.126 , Issue.4 , pp. 801-810
    • Yang, X.1    Downes, M.2    Yu, R.T.3    Bookout, A.L.4    He, W.5    Straume, M.6    Mangelsdorf, D.J.7    Evans, R.M.8
  • 57
    • 70449704430 scopus 로고    scopus 로고
    • Maternal high fat diet during pregnancy and lactation alters hepatic expression of insulin like growth factor-2 and key microRNAs in the adult offspring
    • Zhang J, Zhang F, Didelot X, Bruce KD, Cagampang FR, Vatish M, Hanson M, Lehnert H, Ceriello A, Byrne CD. 2009. Maternal high fat diet during pregnancy and lactation alters hepatic expression of insulin like growth factor-2 and key microRNAs in the adult offspring. BMC Genomics 10:478.
    • (2009) BMC Genomics , vol.10 , pp. 478
    • Zhang, J.1    Zhang, F.2    Didelot, X.3    Bruce, K.D.4    Cagampang, F.R.5    Vatish, M.6    Hanson, M.7    Lehnert, H.8    Ceriello, A.9    Byrne, C.D.10
  • 58
    • 79954543722 scopus 로고    scopus 로고
    • Histone modifications, not DNA methylation, cause transcriptional repression of p16 (CDKN2A) in the mammary glands of offspring of protein-restricted rats
    • Oct 7 [Epub ahead of print]
    • Zheng S, Pan YX. 2010. Histone modifications, not DNA methylation, cause transcriptional repression of p16 (CDKN2A) in the mammary glands of offspring of protein-restricted rats. J Nutr Biochem Oct 7 [Epub ahead of print].
    • (2010) J Nutr Biochem
    • Zheng, S.1    Pan, Y.X.2


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