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Volumn 12, Issue 7, 2011, Pages 647-656

Regulation of mammalian DNA methyltransferases: A route to new mechanisms

Author keywords

DNAna methylation; DNAna methyltransferases; non coding RNArnas; PTptM

Indexed keywords

DNA METHYLTRANSFERASE; LYSINE; MICRORNA; UNTRANSLATED RNA;

EID: 79959990071     PISSN: 1469221X     EISSN: 14693178     Source Type: Journal    
DOI: 10.1038/embor.2011.110     Document Type: Review
Times cited : (302)

References (86)
  • 5
    • 51349116001 scopus 로고    scopus 로고
    • Amammalian microRNAcluster controls DNAmethylation and telomere recombination via Rbl2-dependent regulation of DNAmethyltransferases
    • Benetti Ret al (2008) Amammalian microRNAcluster controls DNAmethylation and telomere recombination via Rbl2-dependent regulation of DNAmethyltransferases. Nat Struct Mol Biol 15: 998
    • (2008) Nat Struct Mol Biol , vol.15 , pp. 998
    • Benetti, R.1
  • 6
    • 0023701018 scopus 로고
    • Cloning and sequencing of a cDNAencoding DNAmethyltransferase of mouse cells. The carboxyl-terminal domain of the mammalian enzymes is related to bacterial restriction methyltransferases
    • Bestor T, Laudano A, Mattaliano R, Ingram V (1988) Cloning and sequencing of a cDNAencoding DNAmethyltransferase of mouse cells. The carboxyl-terminal domain of the mammalian enzymes is related to bacterial restriction methyltransferases. J Mol Biol 203: 971-983
    • (1988) J Mol Biol , vol.203 , pp. 971-983
    • Bestor, T.1    Laudano, A.2    Mattaliano, R.3    Ingram, V.4
  • 7
    • 0036144048 scopus 로고    scopus 로고
    • DNAmethylation patterns and epigenetic memory
    • Bird A(2002) DNAmethylation patterns and epigenetic memory. Genes Dev 16: 6-21
    • (2002) Genes Dev , vol.16 , pp. 6-21
    • Bird, A.1
  • 8
    • 77950600443 scopus 로고    scopus 로고
    • MicroRNA-dependent regulation of DNAmethyltransferase-1 and tumor suppressor gene expression by interleukin-6 in human malignant cholangiocytes
    • Braconi C, Huang N, Patel T(2010) MicroRNA-dependent regulation of DNAmethyltransferase-1 and tumor suppressor gene expression by interleukin-6 in human malignant cholangiocytes. Hepatology 51: 881-890
    • (2010) Hepatology , vol.51 , pp. 881-890
    • Braconi, C.1    Huang, N.2    Patel, T.3
  • 10
    • 34249290027 scopus 로고    scopus 로고
    • A methylation rendezvous: Reader meets writers
    • DOI 10.1016/j.devcel.2007.05.011, PII S1534580707002067
    • Brenner C, Fuks F (2007) Amethylation rendezvous: reader meets writers. Dev Cell 12: 843-844 (Pubitemid 46805929)
    • (2007) Developmental Cell , vol.12 , Issue.6 , pp. 843-844
    • Brenner, C.1    Fuks, F.2
  • 11
    • 79251504611 scopus 로고    scopus 로고
    • Control of DNMT1 abundance in epigenetic inheritance by acetylation, ubiquitylation, and the histone code
    • Bronner C(2011) Control of DNMT1 abundance in epigenetic inheritance by acetylation, ubiquitylation, and the histone code. Sci Signal 4: pe3
    • (2011) Sci Signal , vol.4
    • Bronner, C.1
  • 12
    • 67349190247 scopus 로고    scopus 로고
    • Linking DNAmethylation and histone modification: Patterns and paradigms
    • Cedar H, Bergman Y(2009) Linking DNAmethylation and histone modification: patterns and paradigms. Nat Rev Genet 10: 295-304
    • (2009) Nat Rev Genet , vol.10 , pp. 295-304
    • Cedar, H.1    Bergman, Y.2
  • 13
    • 0032480226 scopus 로고    scopus 로고
    • DNA hypomethylation leads to elevated mutation rates
    • DOI 10.1038/25779
    • Chen RZ, Pettersson U, Beard C, Jackson-Grusby L, Jaenisch R(1998) DNAhypomethylation leads to elevated mutation rates. Nature 395: 89-93 (Pubitemid 28420236)
    • (1998) Nature , vol.395 , Issue.6697 , pp. 89-93
    • Chen, R.Z.1    Pettersson, U.2    Beard, C.3    Jackson-Grusby, L.4    Jaenisch, R.5
  • 14
    • 77950678085 scopus 로고    scopus 로고
    • Coordinated chromatin control: Structural and functional linkage of DNAand histone methylation
    • Cheng X, Blumenthal RM (2010) Coordinated chromatin control: structural and functional linkage of DNAand histone methylation. Biochemistry 49: 2999-3008
    • (2010) Biochemistry , vol.49 , pp. 2999-3008
    • Cheng, X.1    Blumenthal, R.M.2
  • 18
    • 78049510229 scopus 로고    scopus 로고
    • DNMT1 stability is regulated by proteins coordinating deubiquitination and acetylation-driven ubiquitination
    • Du Zet al (2010) DNMT1 stability is regulated by proteins coordinating deubiquitination and acetylation-driven ubiquitination. Sci Signal 3: ra80
    • (2010) Sci Signal , vol.3
    • Du, Z.1
  • 19
    • 42449086421 scopus 로고    scopus 로고
    • MiR-148 targets human DNMT3b protein coding region
    • DOI 10.1261/rna.972008
    • Duursma AM, Kedde M, Schrier M, le Sage C, Agami R(2008) miR-148 targets human DNMT3b protein coding region. RNA 14: 872-877 (Pubitemid 351574909)
    • (2008) RNA , vol.14 , Issue.5 , pp. 872-877
    • Duursma, A.M.1    Kedde, M.2    Schrier, M.3    Le Sage, C.4    Agami, R.5
  • 23
    • 77952734605 scopus 로고    scopus 로고
    • Conservation and divergence of methylation patterning in plants and animals
    • Feng S et al (2010) Conservation and divergence of methylation patterning in plants and animals. Proc Natl Acad Sci USA 107: 8689-8694
    • (2010) Proc Natl Acad Sci USA , vol.107 , pp. 8689-8694
    • Feng, S.1
  • 24
    • 38349169664 scopus 로고    scopus 로고
    • Mechanisms of post-transcriptional regulation by microRNAs: Are the answers in sight?
    • Filipowicz W, Bhattacharyya SN, Sonenberg N(2008) Mechanisms of post-transcriptional regulation by microRNAs: are the answers in sight? Nat Rev Genet 9: 102-114
    • (2008) Nat Rev Genet , vol.9 , pp. 102-114
    • Filipowicz, W.1    Bhattacharyya, S.N.2    Sonenberg, N.3
  • 25
    • 79955473684 scopus 로고    scopus 로고
    • OPERating Chromatin on a Colorful Language where Context Matters
    • Gardner KE, Allis CD, Strahl BD (2011) OPERating Chromatin ON, a Colorful Language where Context Matters. J Mol Biol 409: 36-46
    • (2011) J Mol Biol , vol.409 , pp. 36-46
    • Gardner, K.E.1    Allis, C.D.2    Strahl, B.D.3
  • 26
    • 67650588646 scopus 로고    scopus 로고
    • MicroRNA-29b induces global DNAhypomethylation and tumor suppressor gene reexpression in acute myeloid leukemia by targeting directly DNMT3Aand 3B and indirectly DNMT1
    • Garzon Ret al (2009) MicroRNA-29b induces global DNAhypomethylation and tumor suppressor gene reexpression in acute myeloid leukemia by targeting directly DNMT3Aand 3B and indirectly DNMT1. Blood 113: 6411-6418
    • (2009) Blood , vol.113 , pp. 6411-6418
    • Garzon, R.1
  • 27
    • 0030743025 scopus 로고    scopus 로고
    • Peptide mapping of the murine DNA methyltransferase reveals a major phosphorylation site and the start of translation
    • DOI 10.1074/jbc.272.28.17851
    • Glickman JF, Pavlovich JG, Reich NO(1997) Peptide mapping of the murine DNAmethyltransferase reveals a major phosphorylation site and the start of translation. J Biol Chem 272: 17851-17857 (Pubitemid 27311228)
    • (1997) Journal of Biological Chemistry , vol.272 , Issue.28 , pp. 17851-17857
    • Glickman, J.F.1    Pavlovich, J.G.2    Reich, N.O.3
  • 28
    • 15744401773 scopus 로고    scopus 로고
    • Eukaryotic cytosine methyltransferases
    • DOI 10.1146/annurev.biochem.74.010904.153721
    • Goll MG, Bestor TH (2005) Eukaryotic cytosine methyltransferases. Annu Rev Biochem 74: 481-514 (Pubitemid 40995515)
    • (2005) Annual Review of Biochemistry , vol.74 , pp. 481-514
    • Goll, M.G.1    Bestor, T.H.2
  • 29
    • 0035933337 scopus 로고    scopus 로고
    • Enzymatic properties of recombinant Dnmt3a DNA methyltransferase from mouse: The enzyme modifies DNA in a non-processive manner and also methylates non-CpA sites
    • DOI 10.1006/jmbi.2001.4710
    • Gowher H, Jeltsch A(2001) Enzymatic properties of recombinant Dnmt3a DNAmethyltransferase from mouse: the enzyme modifies DNAin a non-processive manner and also methylates non-CpG[correction of non-CpA] sites. J Mol Biol 309: 1201-1208 (Pubitemid 32623318)
    • (2001) Journal of Molecular Biology , vol.309 , Issue.5 , pp. 1201-1208
    • Gowher, H.1    Jeltsch, A.2
  • 30
    • 36749000637 scopus 로고    scopus 로고
    • Phosphorylation of serine-515 activates the mammalian maintenance methyltransferase Dnmt1
    • Goyal R, Rathert P, Laser H, Gowher H, Jeltsch A(2007) Phosphorylation of serine-515 activates the mammalian maintenance methyltransferase Dnmt1. Epigenetics 2: 155-160 (Pubitemid 350200393)
    • (2007) Epigenetics , vol.2 , Issue.3 , pp. 155-160
    • Goyal, R.1    Rathert, P.2    Laser, H.3    Gowher, H.4    Jeltsch, A.5
  • 31
    • 18044393242 scopus 로고    scopus 로고
    • Profound flanking sequence preference of Dnmt3a and Dnmt3b mammalian DNA methyltransferases shape the human epigenome
    • DOI 10.1016/j.jmb.2005.02.044
    • Handa V, Jeltsch A(2005) Profound flanking sequence preference of Dnmt3a and Dnmt3b mammalian DNAmethyltransferases shape the human epigenome. J Mol Biol 348: 1103-1112 (Pubitemid 40602369)
    • (2005) Journal of Molecular Biology , vol.348 , Issue.5 , pp. 1103-1112
    • Handa, V.1    Jeltsch, A.2
  • 32
    • 66249108936 scopus 로고    scopus 로고
    • Promoter targeted small RNAs induce long-term transcriptional gene silencing in human cells
    • Hawkins PG, Santoso S, Adams C, Anest V, Morris KV (2009) Promoter targeted small RNAs induce long-term transcriptional gene silencing in human cells. Nucleic Acids Res 37: 2984-2995
    • (2009) Nucleic Acids Res , vol.37 , pp. 2984-2995
    • Hawkins, P.G.1    Santoso, S.2    Adams, C.3    Anest, V.4    Morris, K.V.5
  • 34
    • 69749092741 scopus 로고    scopus 로고
    • High definition profiling of mammalian DNAmethylation by array capture and single molecule bisulfite sequencing
    • Hodges E et al (2009) High definition profiling of mammalian DNAmethylation by array capture and single molecule bisulfite sequencing. Genome Res 19: 1593-1605
    • (2009) Genome Res , vol.19 , pp. 1593-1605
    • Hodges, E.1
  • 35
    • 38049164130 scopus 로고    scopus 로고
    • Activation and transposition of endogenous retroviral elements in hypomethylation induced tumors in mice
    • Howard G, Eiges R, Gaudet F, Jaenisch R, Eden A(2008) Activation and transposition of endogenous retroviral elements in hypomethylation induced tumors in mice. Oncogene 27: 404-408
    • (2008) Oncogene , vol.27 , pp. 404-408
    • Howard, G.1    Eiges, R.2    Gaudet, F.3    Jaenisch, R.4    Eden, A.5
  • 36
    • 77954234485 scopus 로고    scopus 로고
    • Down-regulated microRNA-152 induces aberrant DNAmethylation in hepatitis B virus-related hepatocellular carcinoma by targeting DNAmethyltransferase 1
    • Huang J, Wang Y, Guo Y, Sun S (2010) Down-regulated microRNA-152 induces aberrant DNAmethylation in hepatitis B virus-related hepatocellular carcinoma by targeting DNAmethyltransferase 1. Hepatology 52: 60-70
    • (2010) Hepatology , vol.52 , pp. 60-70
    • Huang, J.1    Wang, Y.2    Guo, Y.3    Sun, S.4
  • 38
    • 10344250458 scopus 로고    scopus 로고
    • Components of the DNA methylation system of chromatin control are RNA-binding proteins
    • DOI 10.1074/jbc.M409070200
    • Jeffery L, Nakielny S (2004) Components of the DNAmethylation system of chromatin control are RNA-binding proteins. J Biol Chem 279: 49479-49487 (Pubitemid 39625835)
    • (2004) Journal of Biological Chemistry , vol.279 , Issue.47 , pp. 49479-49487
    • Jeffery, L.1    Nakielny, S.2
  • 40
    • 34548603504 scopus 로고    scopus 로고
    • Structure of Dnmt3a bound to Dnmt3L suggests a model for de novo DNA methylation
    • DOI 10.1038/nature06146, PII NATURE06146
    • Jia D, Jurkowska RZ, Zhang X, Jeltsch A, Cheng X (2007) Structure of Dnmt3a bound to Dnmt3Lsuggests a model for de novo DNAmethylation. Nature 449: 248-251 (Pubitemid 47402375)
    • (2007) Nature , vol.449 , Issue.7159 , pp. 248-251
    • Jia, D.1    Jurkowska, R.Z.2    Zhang, X.3    Jeltsch, A.4    Cheng, X.5
  • 41
    • 33847065486 scopus 로고    scopus 로고
    • The epigenomics of cancer
    • DOI 10.1016/j.cell.2007.01.029, PII S0092867407001274
    • Jones PA, Baylin SB (2007) The epigenomics of cancer. Cell 128: 683-692 (Pubitemid 46273572)
    • (2007) Cell , vol.128 , Issue.4 , pp. 683-692
    • Jones, P.A.1    Baylin, S.B.2
  • 42
    • 78751470921 scopus 로고    scopus 로고
    • Structure and function of mammalian DNAmethyltransferases
    • Jurkowska RZ, Jurkowski TP, Jeltsch A(2011) Structure and function of mammalian DNAmethyltransferases. Chembiochem 12: 206-222
    • (2011) Chembiochem , vol.12 , pp. 206-222
    • Jurkowska, R.Z.1    Jurkowski, T.P.2    Jeltsch, A.3
  • 44
    • 0035861938 scopus 로고    scopus 로고
    • Dnmt3b, de Novo DNA methyltransferase, interacts with SUMO-1 and Ubc9 through its N-terminal region and is subject to modification by SUMO-1
    • DOI 10.1006/bbrc.2001.6057
    • Kang ES, Park CW, Chung JH (2001) Dnmt3b, de novo DNAmethyltransferase, interacts with SUMO-1 and Ubc9 through its N-terminal region and is subject to modification by SUMO-1. Biochem Biophys Res Commun 289: 862-868 (Pubitemid 34060084)
    • (2001) Biochemical and Biophysical Research Communications , vol.289 , Issue.4 , pp. 862-868
    • Kang, E.S.1    Park, C.W.2    Chung, J.H.3
  • 49
    • 77649267695 scopus 로고    scopus 로고
    • Dynamic changes in the human methylome during differentiation
    • Laurent Let al (2010) Dynamic changes in the human methylome during differentiation. Genome Res 20: 320-331
    • (2010) Genome Res , vol.20 , pp. 320-331
    • Laurent, L.1
  • 50
    • 69249241855 scopus 로고    scopus 로고
    • SUMOylation enhances DNAmethyltransferase 1 activity
    • Lee B, Muller MT(2009) SUMOylation enhances DNAmethyltransferase 1 activity. Biochem J 421: 449-461
    • (2009) Biochem J , vol.421 , pp. 449-461
    • Lee, B.1    Muller, M.T.2
  • 52
    • 0026708177 scopus 로고
    • Targeted mutation of the DNAmethyltransferase gene results in embryonic lethality
    • Li E, Bestor TH, Jaenisch R(1992) Targeted mutation of the DNAmethyltransferase gene results in embryonic lethality. Cell 69: 915-926
    • (1992) Cell , vol.69 , pp. 915-926
    • Li, E.1    Bestor, T.H.2    Jaenisch, R.3
  • 53
    • 1342306395 scopus 로고    scopus 로고
    • Modification of de novo DNA methyltransferase 3a (Dnmt3a) by SUMO-1 modulates its interaction with histone deacetylases (HDACs) and its capacity to repress transcription
    • DOI 10.1093/nar/gkh195
    • Ling Y, Sankpal UT, Robertson AK, McNally JG, Karpova T, Robertson KD (2004) Modification of de novo DNA methyl transferase 3a (Dnmt3a) by SUMO-1 modulates its interaction with histone deacetylases (HDACs) and its capacity to repress transcription. Nucleic Acids Res 32: 598-610 (Pubitemid 38263051)
    • (2004) Nucleic Acids Research , vol.32 , Issue.2 , pp. 598-610
    • Ling, Y.1    Sankpal, U.T.2    Robertson, A.K.3    McNally, J.G.4    Karpova, T.5    Robertson, K.D.6
  • 55
    • 70450217879 scopus 로고    scopus 로고
    • Human DNAmethylomes at base resolution show widespread epigenomic differences
    • Lister Ret al (2009) Human DNAmethylomes at base resolution show widespread epigenomic differences. Nature 462: 315-322
    • (2009) Nature , vol.462 , pp. 315-322
    • Lister, R.1
  • 56
    • 65849331461 scopus 로고    scopus 로고
    • The RNA-binding protein HuRregulates DNAmethylation through stabilization of DNMT3b mRNA
    • Lopez de Silanes Iet al (2009) The RNA-binding protein HuRregulates DNAmethylation through stabilization of DNMT3b mRNA. Nucleic Acids Res 37: 2658-2671
    • (2009) Nucleic Acids Res , vol.37 , pp. 2658-2671
    • Lopez De Silanes, I.1
  • 58
    • 49649125042 scopus 로고    scopus 로고
    • Genome-scale DNAmethylation maps of pluripotent and differentiated cells
    • Meissner Aet al (2008) Genome-scale DNAmethylation maps of pluripotent and differentiated cells. Nature 454: 766-770
    • (2008) Nature , vol.454 , pp. 766-770
    • Meissner, A.1
  • 59
    • 78049235116 scopus 로고    scopus 로고
    • Proteomic analyses identify a diverse array of nuclear processes affected by small ubiquitin-like modifier conjugation in Arabidopsis
    • Miller MJ, Barrett-Wilt GA, Hua Z, Vierstra RD (2010) Proteomic analyses identify a diverse array of nuclear processes affected by small ubiquitin-like modifier conjugation in Arabidopsis. Proc Natl Acad Sci USA 107: 16512-16517
    • (2010) Proc Natl Acad Sci USA , vol.107 , pp. 16512-16517
    • Miller, M.J.1    Barrett-Wilt, G.A.2    Hua, Z.3    Vierstra, R.D.4
  • 62
    • 70449099301 scopus 로고    scopus 로고
    • Structural basis for recognition of H3K4 methylation status by the DNAmethyltransferase 3AATRX-DNMT3-DNMT3Ldomain
    • Otani J, Nankumo T, Arita K, Inamoto S, Ariyoshi M, Shirakawa M (2009) Structural basis for recognition of H3K4 methylation status by the DNAmethyltransferase 3AATRX-DNMT3-DNMT3Ldomain. EMBO Rep 10: 1235-1241
    • (2009) EMBO Rep , vol.10 , pp. 1235-1241
    • Otani, J.1    Nankumo, T.2    Arita, K.3    Inamoto, S.4    Ariyoshi, M.5    Shirakawa, M.6
  • 63
    • 77953624215 scopus 로고    scopus 로고
    • MicroRNA-21 and microRNA-148a contribute to DNAhypomethylation in lupus CD4+ T cells by directly and indirectly targeting DNAmethyltransferase 1
    • Pan W, Zhu S, Yuan M, Cui H, Wang L, Luo X, Li J, Zhou H, Tang Y, Shen N(2010) MicroRNA-21 and microRNA-148a contribute to DNAhypomethylation in lupus CD4+ T cells by directly and indirectly targeting DNAmethyltransferase 1. J Immunol 184: 6773-6781
    • (2010) J Immunol , vol.184 , pp. 6773-6781
    • Pan, W.1    Zhu, S.2    Yuan, M.3    Cui, H.4    Wang, L.5    Luo, X.6    Li, J.7    Zhou, H.8    Tang, Y.9    Shen, N.10
  • 64
    • 77957970301 scopus 로고    scopus 로고
    • Epigenetic modifications and human disease
    • Portela A, Esteller M (2010) Epigenetic modifications and human disease. Nat Biotechnol 28: 1057-1068
    • (2010) Nat Biotechnol , vol.28 , pp. 1057-1068
    • Portela, A.1    Esteller, M.2
  • 65
    • 33750435234 scopus 로고    scopus 로고
    • Distinct catalytic and non-catalytic roles of ARGONAUTE4 in RNA-directed DNA methylation
    • DOI 10.1038/nature05198, PII NATURE05198
    • Qi Y, He X, Wang XJ, Kohany O, Jurka J, Hannon GJ (2006) Distinct catalytic and non-catalytic roles of ARGONAUTE4 in RNA-directed DNAmethylation. Nature 443: 1008-1012 (Pubitemid 44646179)
    • (2006) Nature , vol.443 , Issue.7114 , pp. 1008-1012
    • Qi, Y.1    He, X.2    Wang, X.-J.3    Kohany, O.4    Jurka, J.5    Hannon, G.J.6
  • 66
    • 0035839126 scopus 로고    scopus 로고
    • Epigenetic reprogramming in mammalian development
    • DOI 10.1126/science.1063443
    • Reik W, Dean W, Walter J (2001) Epigenetic reprogramming in mammalian development. Science 293: 1089-1093 (Pubitemid 32758081)
    • (2001) Science , vol.293 , Issue.5532 , pp. 1089-1093
    • Reik, W.1    Dean, W.2    Walter, J.3
  • 67
    • 22844457491 scopus 로고    scopus 로고
    • DNAmethylation and human disease
    • Robertson KD (2005) DNAmethylation and human disease. Nat Rev Genet 6: 597-610
    • (2005) Nat Rev Genet , vol.6 , pp. 597-610
    • Robertson, K.D.1
  • 69
    • 77958576363 scopus 로고    scopus 로고
    • Interaction of noncoding RNAwith the rDNApromoter mediates recruitment of DNMT3b and silencing of rRNAgenes
    • Schmitz KM, Mayer C, Postepska A, Grummt I(2010) Interaction of noncoding RNAwith the rDNApromoter mediates recruitment of DNMT3b and silencing of rRNAgenes. Genes Dev 24: 2264-2269
    • (2010) Genes Dev , vol.24 , pp. 2264-2269
    • Schmitz, K.M.1    Mayer, C.2    Postepska, A.3    Grummt, I.4
  • 71
    • 79952258043 scopus 로고    scopus 로고
    • Nucleosomes containing methylated DNAstabilize DNAmethyltransferases 3A/3B and ensure faithful epigenetic inheritance
    • Sharma S, De Carvalho DD, Jeong S, Jones PA, Liang G(2011) Nucleosomes containing methylated DNAstabilize DNAmethyltransferases 3A/3B and ensure faithful epigenetic inheritance. PLoS Genet 7: e1001286
    • (2011) PLoS Genet , vol.7
    • Sharma, S.1    De Carvalho, D.D.2    Jeong, S.3    Jones, P.A.4    Liang, G.5
  • 73
    • 78651280460 scopus 로고    scopus 로고
    • Selective chemical labeling reveals the genome-wide distribution of 5-hydroxymethylcytosine
    • Song CX et al (2011) Selective chemical labeling reveals the genome-wide distribution of 5-hydroxymethylcytosine. Nat Biotechnol 29: 68-72
    • (2011) Nat Biotechnol , vol.29 , pp. 68-72
    • Song, C.X.1
  • 75
    • 67650998877 scopus 로고    scopus 로고
    • Potential role of miR-29b in modulation of Dnmt3a and Dnmt3b expression in primordial germ cells of female mouse embryos
    • Takada S, Berezikov E, Choi YL, Yamashita Y, Mano H (2009) Potential role of miR-29b in modulation of Dnmt3a and Dnmt3b expression in primordial germ cells of female mouse embryos. RNA 15: 1507-1514
    • (2009) RNA , vol.15 , pp. 1507-1514
    • Takada, S.1    Berezikov, E.2    Choi, Y.L.3    Yamashita, Y.4    Mano, H.5
  • 76
    • 63649088662 scopus 로고    scopus 로고
    • Mobilization-competent lentiviral vector-mediated sustained transcriptional modulation of HIV-1 expression
    • Turner AM, De La Cruz J, Morris KV (2009) Mobilization-competent lentiviral vector-mediated sustained transcriptional modulation of HIV-1 expression. Mol Ther 17: 360-368
    • (2009) Mol Ther , vol.17 , pp. 360-368
    • Turner, A.M.1    De La Cruz, J.2    Morris, K.V.3
  • 78
    • 0037295721 scopus 로고    scopus 로고
    • Modification with SUMOArole in transcriptional regulation
    • Verger A, Perdomo J, Crossley M (2003) Modification with SUMOArole in transcriptional regulation. EMBO Rep 4: 137-142
    • (2003) EMBO Rep , vol.4 , pp. 137-142
    • Verger, A.1    Perdomo, J.2    Crossley, M.3
  • 80
    • 58149156264 scopus 로고    scopus 로고
    • The lysine demethylase LSD1 (KDM1) is required for maintenance of global DNAmethylation
    • Wang J et al (2009) The lysine demethylase LSD1 (KDM1) is required for maintenance of global DNAmethylation. Nat Genet 41: 125-129
    • (2009) Nat Genet , vol.41 , pp. 125-129
    • Wang, J.1
  • 81
    • 34047116826 scopus 로고    scopus 로고
    • Distribution, silencing potential and evolutionary impact of promoter DNA methylation in the human genome
    • DOI 10.1038/ng1990, PII NG1990
    • Weber M, Hellmann I, Stadler MB, Ramos L, Paabo S, Rebhan M, Schubeler D (2007) Distribution, silencing potential and evolutionary impact of promoter DNAmethylation in the human genome. Nat Genet 39: 457-466 (Pubitemid 46514772)
    • (2007) Nature Genetics , vol.39 , Issue.4 , pp. 457-466
    • Weber, M.1    Hellmann, I.2    Stadler, M.B.3    Ramos, L.4    Paabo, S.5    Rebhan, M.6    Schubeler, D.7
  • 82
    • 31044433795 scopus 로고    scopus 로고
    • The antisense strand of small interfering RNAs directs histone methylation and transcriptional gene silencing in human cells
    • DOI 10.1261/rna.2235106
    • Weinberg MS, Villeneuve LM, Ehsani A, Amarzguioui M, Aagaard L, Chen ZX, Riggs AD, Rossi JJ, Morris KV (2006) The antisense strand of small interfering RNAs directs histone methylation and transcriptional gene silencing in human cells. RNA 12: 256-262 (Pubitemid 43121930)
    • (2006) RNA , vol.12 , Issue.2 , pp. 256-262
    • Weinberg, M.S.1    Villeneuve, L.M.2    Ehsani, A.3    Amarzguioui, M.4    Aagaard, L.5    Chen, Z.-X.6    Riggs, A.D.7    Rossi, J.J.8    Morris, K.V.9
  • 83
    • 77954842322 scopus 로고    scopus 로고
    • Dnmt3a-dependent nonpromoter DNAmethylation facilitates transcription of neurogenic genes
    • Wu H, Coskun V, Tao J, Xie W, Ge W, Yoshikawa K, Li E, Zhang Y, Sun YE (2010) Dnmt3a-dependent nonpromoter DNAmethylation facilitates transcription of neurogenic genes. Science 329: 444-448
    • (2010) Science , vol.329 , pp. 444-448
    • Wu, H.1    Coskun, V.2    Tao, J.3    Xie, W.4    Ge, W.5    Yoshikawa, K.6    Li, E.7    Zhang, Y.8    Sun, Y.E.9
  • 84
    • 77954126183 scopus 로고    scopus 로고
    • Chromatin methylation activity of Dnmt3a and Dnmt3a/3Lis guided by interaction of the ADD domain with the histone H3 tail
    • Zhang Yet al (2010) Chromatin methylation activity of Dnmt3a and Dnmt3a/3Lis guided by interaction of the ADD domain with the histone H3 tail. Nucleic Acids Res 38: 4246-4253
    • (2010) Nucleic Acids Res , vol.38 , pp. 4246-4253
    • Zhang, Y.1
  • 85
    • 62049086288 scopus 로고    scopus 로고
    • PRMT5-mediated methylation of histone H4R3 recruits DNMT3A, coupling histone and DNAmethylation in gene silencing
    • Zhao Q et al (2009) PRMT5-mediated methylation of histone H4R3 recruits DNMT3A, coupling histone and DNAmethylation in gene silencing. Nat Struct Mol Biol 16: 304-311
    • (2009) Nat Struct Mol Biol , vol.16 , pp. 304-311
    • Zhao, Q.1
  • 86
    • 79955569628 scopus 로고    scopus 로고
    • MicroRNA-126 regulates DNAmethylation in CD4(+) T cells and contributes to systemic lupus erythematosus by targeting DNAmethyltransferase 1
    • Zhao S, Wang Y, Liang Y, Zhao M, Long H, Ding S, Yin H, Lu Q (2011) MicroRNA-126 regulates DNAmethylation in CD4(+) T cells and contributes to systemic lupus erythematosus by targeting DNAmethyltransferase 1. Arthritis Rheum 63: 1376-1386
    • (2011) Arthritis Rheum , vol.63 , pp. 1376-1386
    • Zhao, S.1    Wang, Y.2    Liang, Y.3    Zhao, M.4    Long, H.5    Ding, S.6    Yin, H.7    Lu, Q.8


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