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Volumn 269, Issue 2, 2008, Pages 291-304

Multi-targeted prevention of cancer by sulforaphane

Author keywords

Chemoprevention; Colorectal cancer; Prostate cancer; Sulforaphane

Indexed keywords

CARCINOGEN; HISTONE DEACETYLASE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE; REACTIVE OXYGEN METABOLITE; SULFORAPHANE;

EID: 51349088974     PISSN: 03043835     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.canlet.2008.04.018     Document Type: Review
Times cited : (471)

References (68)
  • 4
    • 0035155096 scopus 로고    scopus 로고
    • Glucosinolates - biochemistry, genetics and biological activity
    • Mithen R. Glucosinolates - biochemistry, genetics and biological activity. Plant Growth Regul. 34 (2001) 91-103
    • (2001) Plant Growth Regul. , vol.34 , pp. 91-103
    • Mithen, R.1
  • 5
    • 0026577605 scopus 로고
    • A major inducer of anticarcinogenic protective enzymes from broccoli: isolation and elucidation of structure
    • Zhang Y., Talalay P., Cho C.G., and Posner G.H. A major inducer of anticarcinogenic protective enzymes from broccoli: isolation and elucidation of structure. Proc. Natl. Acad. Sci. USA 89 (1992) 2399-2403
    • (1992) Proc. Natl. Acad. Sci. USA , vol.89 , pp. 2399-2403
    • Zhang, Y.1    Talalay, P.2    Cho, C.G.3    Posner, G.H.4
  • 6
    • 34047136753 scopus 로고    scopus 로고
    • Cruciferous vegetables and human cancer risk: epidemiologic evidence and mechanistic basis
    • Higdon J.V., Delage B., Williams D.E., and Dashwood R.H. Cruciferous vegetables and human cancer risk: epidemiologic evidence and mechanistic basis. Pharmacol. Res. 55 (2007) 224-236
    • (2007) Pharmacol. Res. , vol.55 , pp. 224-236
    • Higdon, J.V.1    Delage, B.2    Williams, D.E.3    Dashwood, R.H.4
  • 7
    • 34247606510 scopus 로고    scopus 로고
    • Molecular basis for chemoprevention by sulforaphane: a comprehensive review
    • Juge N., Mithen R.F., and Traka M. Molecular basis for chemoprevention by sulforaphane: a comprehensive review. Cell Mol. Life Sci. 64 (2007) 1105-1127
    • (2007) Cell Mol. Life Sci. , vol.64 , pp. 1105-1127
    • Juge, N.1    Mithen, R.F.2    Traka, M.3
  • 8
    • 0026577605 scopus 로고
    • A major inducer of anticarcinogenic protective enzymes from broccoli: isolation and elucidation of structure
    • Zhang Y., Talalay P., Cho C.G., and Posner G.H. A major inducer of anticarcinogenic protective enzymes from broccoli: isolation and elucidation of structure. Proc. Natl. Acad. Sci. USA 89 (1992) 2399-2403
    • (1992) Proc. Natl. Acad. Sci. USA , vol.89 , pp. 2399-2403
    • Zhang, Y.1    Talalay, P.2    Cho, C.G.3    Posner, G.H.4
  • 9
    • 0030852501 scopus 로고    scopus 로고
    • Inhibition of cytochromes p-450 and induction of glutathione s-transferases by sulforaphane in primary human and rat hepatocytes
    • Maheo K., Morel F., Langouet S., Kramer H., Le Ferrec E., Ketterer B., and Guillouzo A. Inhibition of cytochromes p-450 and induction of glutathione s-transferases by sulforaphane in primary human and rat hepatocytes. Cancer Res. 57 (1997) 3649-3652
    • (1997) Cancer Res. , vol.57 , pp. 3649-3652
    • Maheo, K.1    Morel, F.2    Langouet, S.3    Kramer, H.4    Le Ferrec, E.5    Ketterer, B.6    Guillouzo, A.7
  • 10
    • 33644646401 scopus 로고    scopus 로고
    • Chemoprotection by sulforaphane: keep one eye beyond keap1
    • Myzak M.C., and Dashwood R.H. Chemoprotection by sulforaphane: keep one eye beyond keap1. Cancer Lett. 233 (2006) 208-218
    • (2006) Cancer Lett. , vol.233 , pp. 208-218
    • Myzak, M.C.1    Dashwood, R.H.2
  • 11
    • 0034854057 scopus 로고    scopus 로고
    • Potent induction of phase 2 enzymes in human prostate cells by sulforaphane
    • Brooks J.D., Paton V.G., and Vidanes G. Potent induction of phase 2 enzymes in human prostate cells by sulforaphane. Cancer Epidemiol. Biomarkers Prev. 10 (2001) 949-954
    • (2001) Cancer Epidemiol. Biomarkers Prev. , vol.10 , pp. 949-954
    • Brooks, J.D.1    Paton, V.G.2    Vidanes, G.3
  • 12
    • 0037947696 scopus 로고    scopus 로고
    • Food matrix effects on bioactivity of broccoli-derived sulforaphane in liver and colon of f344 rats
    • Keck A.S., Qiao Q., and Jeffery E.H. Food matrix effects on bioactivity of broccoli-derived sulforaphane in liver and colon of f344 rats. J. Agric. Food Chem. 51 (2003) 3320-3327
    • (2003) J. Agric. Food Chem. , vol.51 , pp. 3320-3327
    • Keck, A.S.1    Qiao, Q.2    Jeffery, E.H.3
  • 13
    • 33645468736 scopus 로고    scopus 로고
    • Modest induction of phase 2 enzyme activity in the f-344 rat prostate
    • Jones S.B., and Brooks J.D. Modest induction of phase 2 enzyme activity in the f-344 rat prostate. BMC Cancer 6 (2006) 62
    • (2006) BMC Cancer , vol.6 , pp. 62
    • Jones, S.B.1    Brooks, J.D.2
  • 15
    • 0037106099 scopus 로고    scopus 로고
    • Identification of nrf2-regulated genes induced by the chemopreventive agent sulforaphane by oligonucleotide microarray
    • Thimmulappa R.K., Mai K.H., Srisuma S., Kensler T.W., Yamamoto M., and Biswal S. Identification of nrf2-regulated genes induced by the chemopreventive agent sulforaphane by oligonucleotide microarray. Cancer Res. 62 (2002) 5196-5203
    • (2002) Cancer Res. , vol.62 , pp. 5196-5203
    • Thimmulappa, R.K.1    Mai, K.H.2    Srisuma, S.3    Kensler, T.W.4    Yamamoto, M.5    Biswal, S.6
  • 16
    • 33746889956 scopus 로고    scopus 로고
    • Gene expression profiles induced by cancer chemopreventive isothiocyanate sulforaphane in the liver of c57bl/6j mice and c57bl/6j/nrf2 (-/-) mice
    • Hu R., Xu C., Shen G., Jain M.R., Khor T.O., Gopalkrishnan A., Lin W., Reddy B., Chan J.Y., and Kong A.N. Gene expression profiles induced by cancer chemopreventive isothiocyanate sulforaphane in the liver of c57bl/6j mice and c57bl/6j/nrf2 (-/-) mice. Cancer Lett. 243 (2006) 170-192
    • (2006) Cancer Lett. , vol.243 , pp. 170-192
    • Hu, R.1    Xu, C.2    Shen, G.3    Jain, M.R.4    Khor, T.O.5    Gopalkrishnan, A.6    Lin, W.7    Reddy, B.8    Chan, J.Y.9    Kong, A.N.10
  • 17
    • 9744283511 scopus 로고    scopus 로고
    • Transcription factor nrf2 is essential for induction of nad(p)h:quinone oxidoreductase 1, glutathione s-transferases, and glutamate cysteine ligase by broccoli seeds and isothiocyanates
    • McWalter G.K., Higgins L.G., McLellan L.I., Henderson C.J., Song L., Thornalley P.J., Itoh K., Yamamoto M., and Hayes J.D. Transcription factor nrf2 is essential for induction of nad(p)h:quinone oxidoreductase 1, glutathione s-transferases, and glutamate cysteine ligase by broccoli seeds and isothiocyanates. J. Nutr. 134 (2004) 3499S-3506S
    • (2004) J. Nutr. , vol.134
    • McWalter, G.K.1    Higgins, L.G.2    McLellan, L.I.3    Henderson, C.J.4    Song, L.5    Thornalley, P.J.6    Itoh, K.7    Yamamoto, M.8    Hayes, J.D.9
  • 19
    • 34250757157 scopus 로고    scopus 로고
    • Induction of p21 protein protects against sulforaphane-induced mitotic arrest in lncap human prostate cancer cell line
    • Herman-Antosiewicz A., Xiao H., Lew K.L., and Singh S.V. Induction of p21 protein protects against sulforaphane-induced mitotic arrest in lncap human prostate cancer cell line. Mol. Cancer Ther. 6 (2007) 1673-1681
    • (2007) Mol. Cancer Ther. , vol.6 , pp. 1673-1681
    • Herman-Antosiewicz, A.1    Xiao, H.2    Lew, K.L.3    Singh, S.V.4
  • 20
    • 27644553527 scopus 로고    scopus 로고
    • Involvement of c-jun N-terminal kinase in g2/m arrest and caspase-mediated apoptosis induced by sulforaphane in du145 prostate cancer cells
    • Cho S.D., Li G., Hu H., Jiang C., Kang K.S., Lee Y.S., Kim S.H., and Lu J. Involvement of c-jun N-terminal kinase in g2/m arrest and caspase-mediated apoptosis induced by sulforaphane in du145 prostate cancer cells. Nutr. Cancer 52 (2005) 213-224
    • (2005) Nutr. Cancer , vol.52 , pp. 213-224
    • Cho, S.D.1    Li, G.2    Hu, H.3    Jiang, C.4    Kang, K.S.5    Lee, Y.S.6    Kim, S.H.7    Lu, J.8
  • 22
    • 0034162822 scopus 로고    scopus 로고
    • Sulforaphane, a naturally occurring isothiocyanate, induces cell cycle arrest and apoptosis in ht29 human colon cancer cells
    • Gamet-Payrastre L., Li P., Lumeau S., Cassar G., Dupont M.-A., Chevolleau S., Gasc N., Tulliez J., and Terce F. Sulforaphane, a naturally occurring isothiocyanate, induces cell cycle arrest and apoptosis in ht29 human colon cancer cells. Cancer Res. 60 (2000) 1426-1433
    • (2000) Cancer Res. , vol.60 , pp. 1426-1433
    • Gamet-Payrastre, L.1    Li, P.2    Lumeau, S.3    Cassar, G.4    Dupont, M.-A.5    Chevolleau, S.6    Gasc, N.7    Tulliez, J.8    Terce, F.9
  • 23
    • 33644841610 scopus 로고    scopus 로고
    • P53-independent g1 cell cycle arrest of human colon carcinoma cells ht-29 by sulforaphane is associated with induction of p21cip1 and inhibition of expression of cyclin d1
    • Shen G., Xu C., Chen C., Hebbar V., and Kong A.-N. P53-independent g1 cell cycle arrest of human colon carcinoma cells ht-29 by sulforaphane is associated with induction of p21cip1 and inhibition of expression of cyclin d1. Cancer Chemother. Pharmacol. 57 (2006) 317-327
    • (2006) Cancer Chemother. Pharmacol. , vol.57 , pp. 317-327
    • Shen, G.1    Xu, C.2    Chen, C.3    Hebbar, V.4    Kong, A.-N.5
  • 24
    • 0036511358 scopus 로고    scopus 로고
    • Sulforaphane and its metabolite mediate growth arrest and apoptosis in human prostate cancer cells
    • Chiao J.W., Chung F.L., Kancherla R., Ahmed T., Mittelman A., and Conaway C.C. Sulforaphane and its metabolite mediate growth arrest and apoptosis in human prostate cancer cells. Int. J. Oncol. 20 (2002) 631-636
    • (2002) Int. J. Oncol. , vol.20 , pp. 631-636
    • Chiao, J.W.1    Chung, F.L.2    Kancherla, R.3    Ahmed, T.4    Mittelman, A.5    Conaway, C.C.6
  • 25
    • 3843072178 scopus 로고    scopus 로고
    • Targeting cell cycle machinery as a molecular mechanism of sulforaphane in prostate cancer prevention
    • Wang L., Liu D., Ahmed T., Chung F.L., Conaway C., and Chiao J.W. Targeting cell cycle machinery as a molecular mechanism of sulforaphane in prostate cancer prevention. Int. J. Oncol. 24 (2004) 187-192
    • (2004) Int. J. Oncol. , vol.24 , pp. 187-192
    • Wang, L.1    Liu, D.2    Ahmed, T.3    Chung, F.L.4    Conaway, C.5    Chiao, J.W.6
  • 26
    • 19344367171 scopus 로고    scopus 로고
    • Role of pi3k/akt and mek/erk signaling pathways in sulforaphane- and erucin-induced phase ii enzymes and mrp2 transcription, g2/m arrest and cell death in caco-2 cells
    • Jakubikova J., Sedlak J., Mithen R., and Bao Y. Role of pi3k/akt and mek/erk signaling pathways in sulforaphane- and erucin-induced phase ii enzymes and mrp2 transcription, g2/m arrest and cell death in caco-2 cells. Biochem. Pharmacol. 69 (2005) 1543-1552
    • (2005) Biochem. Pharmacol. , vol.69 , pp. 1543-1552
    • Jakubikova, J.1    Sedlak, J.2    Mithen, R.3    Bao, Y.4
  • 27
    • 34548106014 scopus 로고    scopus 로고
    • Biphasic modulation of cell proliferation by sulforaphane at physiologically relevant exposure times in a human colon cancer cell line
    • Pappa G., Bartsch H., and Gerhäuser C. Biphasic modulation of cell proliferation by sulforaphane at physiologically relevant exposure times in a human colon cancer cell line. Mol. Nutr. Food Res. 51 (2007) 977-984
    • (2007) Mol. Nutr. Food Res. , vol.51 , pp. 977-984
    • Pappa, G.1    Bartsch, H.2    Gerhäuser, C.3
  • 28
    • 23244450241 scopus 로고    scopus 로고
    • Transcriptome analysis of human colon caco-2 cells exposed to sulforaphane
    • Traka M., Gasper A.V., Smith J.A., Hawkey C.J., Bao Y., and Mithen R.F. Transcriptome analysis of human colon caco-2 cells exposed to sulforaphane. J. Nutr. 135 (2005) 1865-1872
    • (2005) J. Nutr. , vol.135 , pp. 1865-1872
    • Traka, M.1    Gasper, A.V.2    Smith, J.A.3    Hawkey, C.J.4    Bao, Y.5    Mithen, R.F.6
  • 29
    • 33645324413 scopus 로고    scopus 로고
    • Sulforaphane inhibits histone deacetylase activity in bph-1, lncap and pc-3 prostate epithelial cells
    • Myzak M.C., Hardin K., Wang R., Dashwood R.H., and Ho E. Sulforaphane inhibits histone deacetylase activity in bph-1, lncap and pc-3 prostate epithelial cells. Carcinogenesis 27 (2006) 811-819
    • (2006) Carcinogenesis , vol.27 , pp. 811-819
    • Myzak, M.C.1    Hardin, K.2    Wang, R.3    Dashwood, R.H.4    Ho, E.5
  • 30
    • 33745875948 scopus 로고    scopus 로고
    • Comparison of growth inhibition profiles and mechanisms of apoptosis induction in human colon cancer cell lines by isothiocyanates and indoles from brassicaceae
    • Pappa G., Lichtenberg M., Iori R., Barillari J., Bartsch H., and Gerhauser C. Comparison of growth inhibition profiles and mechanisms of apoptosis induction in human colon cancer cell lines by isothiocyanates and indoles from brassicaceae. Mutat. Res. 599 (2006) 76-87
    • (2006) Mutat. Res. , vol.599 , pp. 76-87
    • Pappa, G.1    Lichtenberg, M.2    Iori, R.3    Barillari, J.4    Bartsch, H.5    Gerhauser, C.6
  • 31
    • 1642545614 scopus 로고    scopus 로고
    • Sulforaphane induces caspase-mediated apoptosis in cultured pc-3 human prostate cancer cells and retards growth of pc-3 xenografts in vivo
    • Singh A.V., Xiao D., Lew K.L., Dhir R., and Singh S.V. Sulforaphane induces caspase-mediated apoptosis in cultured pc-3 human prostate cancer cells and retards growth of pc-3 xenografts in vivo. Carcinogenesis 25 (2004) 83-90
    • (2004) Carcinogenesis , vol.25 , pp. 83-90
    • Singh, A.V.1    Xiao, D.2    Lew, K.L.3    Dhir, R.4    Singh, S.V.5
  • 32
    • 1842631408 scopus 로고    scopus 로고
    • Upregulation and nuclear recruitment of hdac1 in hormone refractory prostate cancer
    • Halkidou K., Gaughan L., Cook S., Leung H.Y., Neal D.E., and Robson C.N. Upregulation and nuclear recruitment of hdac1 in hormone refractory prostate cancer. Prostate 59 (2004) 177-189
    • (2004) Prostate , vol.59 , pp. 177-189
    • Halkidou, K.1    Gaughan, L.2    Cook, S.3    Leung, H.Y.4    Neal, D.E.5    Robson, C.N.6
  • 34
    • 21744457108 scopus 로고    scopus 로고
    • Global histone modification patterns predict risk of prostate cancer recurrence
    • Seligson D.B., Horvath S., Shi T., Yu H., Tze S., Grunstein M., and Kurdistani S.K. Global histone modification patterns predict risk of prostate cancer recurrence. Nature 435 (2005) 1262-1266
    • (2005) Nature , vol.435 , pp. 1262-1266
    • Seligson, D.B.1    Horvath, S.2    Shi, T.3    Yu, H.4    Tze, S.5    Grunstein, M.6    Kurdistani, S.K.7
  • 36
    • 0036527775 scopus 로고    scopus 로고
    • Histone-deacetylase inhibitors: novel drugs for the treatment of cancer
    • Johnstone R.W. Histone-deacetylase inhibitors: novel drugs for the treatment of cancer. Nat. Rev. Drug Discov. 1 (2002) 287-299
    • (2002) Nat. Rev. Drug Discov. , vol.1 , pp. 287-299
    • Johnstone, R.W.1
  • 37
    • 4143130097 scopus 로고    scopus 로고
    • A novel mechanism of chemoprotection by sulforaphane: inhibition of histone deacetylase
    • Myzak M.C., Karplus P.A., Chung F.L., and Dashwood R.H. A novel mechanism of chemoprotection by sulforaphane: inhibition of histone deacetylase. Cancer Res. 64 (2004) 5767-5774
    • (2004) Cancer Res. , vol.64 , pp. 5767-5774
    • Myzak, M.C.1    Karplus, P.A.2    Chung, F.L.3    Dashwood, R.H.4
  • 38
    • 34548456881 scopus 로고    scopus 로고
    • Dietary histone deacetylase inhibitors: from cells to mice to man
    • Dashwood R.H., and Ho E. Dietary histone deacetylase inhibitors: from cells to mice to man. Semin. Cancer Biol. 17 (2007) 363-369
    • (2007) Semin. Cancer Biol. , vol.17 , pp. 363-369
    • Dashwood, R.H.1    Ho, E.2
  • 39
    • 33645825587 scopus 로고    scopus 로고
    • Sulforaphane inhibits histone deacetylase in vivo and suppresses tumorigenesis in apc-minus mice
    • Myzak M.C., Dashwood W.M., Orner G.A., Ho E., and Dashwood R.H. Sulforaphane inhibits histone deacetylase in vivo and suppresses tumorigenesis in apc-minus mice. FASEB J. 20 (2006) 506-508
    • (2006) FASEB J. , vol.20 , pp. 506-508
    • Myzak, M.C.1    Dashwood, W.M.2    Orner, G.A.3    Ho, E.4    Dashwood, R.H.5
  • 40
    • 1842607591 scopus 로고    scopus 로고
    • Modulation of ap-1 by natural chemopreventive compounds in human colon ht-29 cancer cell line
    • Jeong W.S., Kim I.W., Hu R., and Kong A.N. Modulation of ap-1 by natural chemopreventive compounds in human colon ht-29 cancer cell line. Pharm. Res. 21 (2004) 649-660
    • (2004) Pharm. Res. , vol.21 , pp. 649-660
    • Jeong, W.S.1    Kim, I.W.2    Hu, R.3    Kong, A.N.4
  • 41
    • 33644865443 scopus 로고    scopus 로고
    • Erk and jnk signaling pathways are involved in the regulation of activator protein 1 and cell death elicited by three isothiocyanates in human prostate cancer pc-3 cells
    • Xu C., Shen G., Yuan X., Kim J.H., Gopalkrishnan A., Keum Y.S., Nair S., and Kong A.N. Erk and jnk signaling pathways are involved in the regulation of activator protein 1 and cell death elicited by three isothiocyanates in human prostate cancer pc-3 cells. Carcinogenesis 27 (2006) 437-445
    • (2006) Carcinogenesis , vol.27 , pp. 437-445
    • Xu, C.1    Shen, G.2    Yuan, X.3    Kim, J.H.4    Gopalkrishnan, A.5    Keum, Y.S.6    Nair, S.7    Kong, A.N.8
  • 42
    • 33749019130 scopus 로고    scopus 로고
    • Mechanism of action of sulforaphane: inhibition of p38 mitogen-activated protein kinase isoforms contributing to the induction of antioxidant response element-mediated heme oxygenase-1 in human hepatoma hepg2 cells
    • Keum Y.-S., Yu S., Chang P.P.-J., Yuan X., Kim J.-H., Xu C., Han J., Agarwal A., and Kong A.-N.T. Mechanism of action of sulforaphane: inhibition of p38 mitogen-activated protein kinase isoforms contributing to the induction of antioxidant response element-mediated heme oxygenase-1 in human hepatoma hepg2 cells. Cancer Res. 66 (2006) 8804-8813
    • (2006) Cancer Res. , vol.66 , pp. 8804-8813
    • Keum, Y.-S.1    Yu, S.2    Chang, P.P.-J.3    Yuan, X.4    Kim, J.-H.5    Xu, C.6    Han, J.7    Agarwal, A.8    Kong, A.-N.T.9
  • 43
    • 0033596124 scopus 로고    scopus 로고
    • Aberrant rel/nfkb genes and activity in human cancer
    • Rayet B., and Gelinas C. Aberrant rel/nfkb genes and activity in human cancer. Oncogene 18 (1999) 6938-6947
    • (1999) Oncogene , vol.18 , pp. 6938-6947
    • Rayet, B.1    Gelinas, C.2
  • 44
    • 0035137882 scopus 로고    scopus 로고
    • Control of oncogenesis and cancer therapy resistance by the transcription factor nf-{{kappa}}b
    • Baldwin A.S. Control of oncogenesis and cancer therapy resistance by the transcription factor nf-{{kappa}}b. J. Clin. Invest. 107 (2001) 241-246
    • (2001) J. Clin. Invest. , vol.107 , pp. 241-246
    • Baldwin, A.S.1
  • 45
    • 33845623882 scopus 로고    scopus 로고
    • d,l-Sulforaphane-induced cell death in human prostate cancer cells is regulated by inhibitor of apoptosis family proteins and apaf-1
    • Choi S., Lew K.L., Xiao H., Herman-Antosiewicz A., Xiao D., Brown C.K., and Singh S.V. d,l-Sulforaphane-induced cell death in human prostate cancer cells is regulated by inhibitor of apoptosis family proteins and apaf-1. Carcinogenesis 28 (2007) 151-162
    • (2007) Carcinogenesis , vol.28 , pp. 151-162
    • Choi, S.1    Lew, K.L.2    Xiao, H.3    Herman-Antosiewicz, A.4    Xiao, D.5    Brown, C.K.6    Singh, S.V.7
  • 46
    • 22744440329 scopus 로고    scopus 로고
    • Suppression of nf-kappab and nf-kappab-regulated gene expression by sulforaphane and peitc through ikappabalpha, ikk pathway in human prostate cancer pc-3 cells
    • Xu C., Shen G., Chen C., Gelinas C., and Kong A.N. Suppression of nf-kappab and nf-kappab-regulated gene expression by sulforaphane and peitc through ikappabalpha, ikk pathway in human prostate cancer pc-3 cells. Oncogene 24 (2005) 4486-4495
    • (2005) Oncogene , vol.24 , pp. 4486-4495
    • Xu, C.1    Shen, G.2    Chen, C.3    Gelinas, C.4    Kong, A.N.5
  • 47
    • 1842555356 scopus 로고    scopus 로고
    • Modulatory properties of various natural chemopreventive agents on the activation of nf-kappab signaling pathway
    • Jeong W.S., Kim I.W., Hu R., and Kong A.N. Modulatory properties of various natural chemopreventive agents on the activation of nf-kappab signaling pathway. Pharm. Res. 21 (2004) 661-670
    • (2004) Pharm. Res. , vol.21 , pp. 661-670
    • Jeong, W.S.1    Kim, I.W.2    Hu, R.3    Kong, A.N.4
  • 49
    • 33745282435 scopus 로고    scopus 로고
    • Sulforaphane causes autophagy to inhibit release of cytochrome c and apoptosis in human prostate cancer cells
    • Herman-Antosiewicz A., Johnson D.E., and Singh S.V. Sulforaphane causes autophagy to inhibit release of cytochrome c and apoptosis in human prostate cancer cells. Cancer Res. 66 (2006) 5828-5835
    • (2006) Cancer Res. , vol.66 , pp. 5828-5835
    • Herman-Antosiewicz, A.1    Johnson, D.E.2    Singh, S.V.3
  • 50
    • 0000295679 scopus 로고    scopus 로고
    • The myrosinase-glucosinolate system, its organisation and biochemistry
    • Bones A.M., and Rossiter J.T. The myrosinase-glucosinolate system, its organisation and biochemistry. Physiologia Plantarum 97 (1996) 194-208
    • (1996) Physiologia Plantarum , vol.97 , pp. 194-208
    • Bones, A.M.1    Rossiter, J.T.2
  • 51
    • 0030781225 scopus 로고    scopus 로고
    • Biotransformation of the naturally occurring isothiocyanate sulforaphane in the rat: identification of phase i metabolites and glutathione conjugates
    • Kassahun K., Davis M., Hu P., Martin B., and Baillie T. Biotransformation of the naturally occurring isothiocyanate sulforaphane in the rat: identification of phase i metabolites and glutathione conjugates. Chem. Res. Toxicol. 10 (1997) 1228-1233
    • (1997) Chem. Res. Toxicol. , vol.10 , pp. 1228-1233
    • Kassahun, K.1    Davis, M.2    Hu, P.3    Martin, B.4    Baillie, T.5
  • 53
    • 0032406798 scopus 로고    scopus 로고
    • Human metabolism and excretion of cancer chemoprotective glucosinolates and isothiocyanates of cruciferous vegetables
    • Shapiro T.A., Fahey J.W., Wade K.L., Stephenson K.K., and Talalay P. Human metabolism and excretion of cancer chemoprotective glucosinolates and isothiocyanates of cruciferous vegetables. Cancer Epidemiol. Biomarkers Prev. 7 (1998) 1091-1100
    • (1998) Cancer Epidemiol. Biomarkers Prev. , vol.7 , pp. 1091-1100
    • Shapiro, T.A.1    Fahey, J.W.2    Wade, K.L.3    Stephenson, K.K.4    Talalay, P.5
  • 54
    • 34247626240 scopus 로고    scopus 로고
    • The metabolic fate of purified glucoraphanin in f344 rats
    • Bheemreddy R.M., and Jeffery E.H. The metabolic fate of purified glucoraphanin in f344 rats. J. Agric. Food Chem. 55 (2007) 2861-2866
    • (2007) J. Agric. Food Chem. , vol.55 , pp. 2861-2866
    • Bheemreddy, R.M.1    Jeffery, E.H.2
  • 55
    • 0034928041 scopus 로고    scopus 로고
    • Chemoprotective glucosinolates and isothiocyanates of broccoli sprouts: metabolism and excretion in humans
    • Shapiro T.A., Fahey J.W., Wade K.L., Stephenson K.K., and Talalay P. Chemoprotective glucosinolates and isothiocyanates of broccoli sprouts: metabolism and excretion in humans. Cancer Epidemiol. Biomarkers Prev. 10 (2001) 501-508
    • (2001) Cancer Epidemiol. Biomarkers Prev. , vol.10 , pp. 501-508
    • Shapiro, T.A.1    Fahey, J.W.2    Wade, K.L.3    Stephenson, K.K.4    Talalay, P.5
  • 56
    • 28244459182 scopus 로고    scopus 로고
    • Effect of glutathione-s-transferase polymorphisms on the cancer preventive potential of isothiocyanates: an epidemiological perspective
    • Seow A., Vainio H., and Yu M.C. Effect of glutathione-s-transferase polymorphisms on the cancer preventive potential of isothiocyanates: an epidemiological perspective. Mutat. Res. 592 (2005) 58-67
    • (2005) Mutat. Res. , vol.592 , pp. 58-67
    • Seow, A.1    Vainio, H.2    Yu, M.C.3
  • 57
    • 0036792160 scopus 로고    scopus 로고
    • Brassica, biotransformation and cancer risk: genetic polymorphisms alter the preventive effects of cruciferous vegetables
    • Lampe J.W., and Peterson S. Brassica, biotransformation and cancer risk: genetic polymorphisms alter the preventive effects of cruciferous vegetables. J. Nutr. 132 (2002) 2991-2994
    • (2002) J. Nutr. , vol.132 , pp. 2991-2994
    • Lampe, J.W.1    Peterson, S.2
  • 58
    • 0031711928 scopus 로고    scopus 로고
    • Urinary total isothiocyanate (itc) in a population-based sample of middle-aged and older hinese in Singapore: relationship with dietary total itc and glutathione s-transferase m1/t1/p1 genotypes
    • Seow A., Shi C.Y., Chung F.L., Jiao D., Hankin J.H., Lee H.P., Coetzee G.A., and Yu M.C. Urinary total isothiocyanate (itc) in a population-based sample of middle-aged and older hinese in Singapore: relationship with dietary total itc and glutathione s-transferase m1/t1/p1 genotypes. Cancer Epidemiol. Biomarkers Prev. 7 (1998) 775-781
    • (1998) Cancer Epidemiol. Biomarkers Prev. , vol.7 , pp. 775-781
    • Seow, A.1    Shi, C.Y.2    Chung, F.L.3    Jiao, D.4    Hankin, J.H.5    Lee, H.P.6    Coetzee, G.A.7    Yu, M.C.8
  • 59
    • 0036949607 scopus 로고    scopus 로고
    • Dietary isothiocyanates glutathione s-transferase polymorphisms and colorectal cancer risk in the singapore chinese health study
    • Seow A., Yuan J.M., Sun C.L., Van Den Berg D., Lee H.P., and Yu M.C. Dietary isothiocyanates glutathione s-transferase polymorphisms and colorectal cancer risk in the singapore chinese health study. Carcinogenesis 23 (2002) 2055-2061
    • (2002) Carcinogenesis , vol.23 , pp. 2055-2061
    • Seow, A.1    Yuan, J.M.2    Sun, C.L.3    Van Den Berg, D.4    Lee, H.P.5    Yu, M.C.6
  • 62
    • 0036135910 scopus 로고    scopus 로고
    • Quantitative determination of dithiocarbamates in human plasma, serum, erythrocytes and urine: pharmacokinetics of broccoli sprout isothiocyanates in humans
    • Ye L., Dinkova-Kostova A.T., Wade K.L., Zhang Y., Shapiro T.A., and Talalay P. Quantitative determination of dithiocarbamates in human plasma, serum, erythrocytes and urine: pharmacokinetics of broccoli sprout isothiocyanates in humans. Clin Chim. Acta 316 (2002) 43-53
    • (2002) Clin Chim. Acta , vol.316 , pp. 43-53
    • Ye, L.1    Dinkova-Kostova, A.T.2    Wade, K.L.3    Zhang, Y.4    Shapiro, T.A.5    Talalay, P.6
  • 64
    • 33749581701 scopus 로고    scopus 로고
    • Cancer chemoprevention of intestinal polyposis in apcmin/+ mice by sulforaphane, a natural product derived from cruciferous vegetable
    • Hu R., Khor T.O., Shen G., Jeong W.S., Hebbar V., Chen C., Xu C., Reddy B., Chada K., and Kong A.N. Cancer chemoprevention of intestinal polyposis in apcmin/+ mice by sulforaphane, a natural product derived from cruciferous vegetable. Carcinogenesis 27 (2006) 2038-2046
    • (2006) Carcinogenesis , vol.27 , pp. 2038-2046
    • Hu, R.1    Khor, T.O.2    Shen, G.3    Jeong, W.S.4    Hebbar, V.5    Chen, C.6    Xu, C.7    Reddy, B.8    Chada, K.9    Kong, A.N.10
  • 65
    • 0034525122 scopus 로고    scopus 로고
    • Chemoprevention of colonic aberrant crypt foci in fischer rats by sulforaphane and phenethyl isothiocyanate
    • Chung F.L., Conaway C.C., Rao C.V., and Reddy B.S. Chemoprevention of colonic aberrant crypt foci in fischer rats by sulforaphane and phenethyl isothiocyanate. Carcinogenesis 21 (2000) 2287-2291
    • (2000) Carcinogenesis , vol.21 , pp. 2287-2291
    • Chung, F.L.1    Conaway, C.C.2    Rao, C.V.3    Reddy, B.S.4
  • 66
    • 33846838750 scopus 로고    scopus 로고
    • Sulforaphane retards the growth of human pc-3 xenografts and inhibits hdac activity in human subjects
    • Myzak M.C., Tong P., Dashwood W.M., Dashwood R.H., and Ho E. Sulforaphane retards the growth of human pc-3 xenografts and inhibits hdac activity in human subjects. Exp. Biol. Med. (Maywood) 232 (2007) 227-234
    • (2007) Exp. Biol. Med. (Maywood) , vol.232 , pp. 227-234
    • Myzak, M.C.1    Tong, P.2    Dashwood, W.M.3    Dashwood, R.H.4    Ho, E.5


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