MicroRNA-29b induces global DNA hypomethylation and tumor suppressor gene reexpression in acute myeloid leukemia by targeting directly DNMT3A and 3B and indirectly DNMT1

Blood

Volumn 113, Issue 25, 2009, Pages 6411-6418

  Garzon, Ramiro ^a,b   Liu, Shujun ^a,b   Fabbri, Muller ^a,b   Liu, Zhongfa ^a   Heaphy, Catherine E A ^a,b   Callegari, Elisa ^a,b   Schwind, Sebastian ^a,b   Pang, Jiuxia ^a,b   Yu, Jianhua ^a,b   Muthusamy, Natarajan ^a,b   Havelange, Violaine ^a,b   Volinia, Stefano ^a,b   Blum, William ^a,b   Rush, Laura J ^a   Perrotti, Danilo ^a,b   Andreeff, Michael ^c   Bloomfield, Clara D ^a,b   Byrd, John C ^a,b   Chan, Kenneth ^a   Wu, Lai Chu ^a   Croce, Carlo M ^a,b   Marcucci, Guido ^a,b   more..

^a OHIO STATE UNIVERSITY   (United States)

^b OHIO STATE UNIVERSITY   (United States)

^c UNIVERSITY OF TEXAS MD ANDERSON CANCER CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLIN DEPENDENT KINASE INHIBITOR 2B; DNA METHYLTRANSFERASE 1; DNA METHYLTRANSFERASE 3A; DNA METHYLTRANSFERASE 3B; ESR 1 PROTEIN; MICRORNA; MICRORNA 29B; OLIGONUCLEOTIDE; RNA; TRANSACTIVATOR PROTEIN; TRANSCRIPTION FACTOR SP1; UNCLASSIFIED DRUG; DNA (CYTOSINE 5 ) METHYLTRANSFERASE 1; DNA (CYTOSINE 5) METHYLTRANSFERASE; DNA (CYTOSINE-5-)-METHYLTRANSFERASE 1; ESR1 PROTEIN, HUMAN; ESTROGEN RECEPTOR ALPHA; TUMOR PROTEIN;

3' UNTRANSLATED REGION; ACUTE GRANULOCYTIC LEUKEMIA; ARTICLE; CONTROLLED STUDY; DNA METHYLATION; DOWN REGULATION; GENE EXPRESSION; GENE INTERACTION; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN TARGETING; TUMOR SUPPRESSOR GENE; ACUTE DISEASE; BIOSYNTHESIS; CANCER STEM CELL; CELL DIFFERENTIATION; DRUG ANTAGONISM; ENZYME INDUCTION; FELINE IMMUNODEFICIENCY VIRUS; GENE EXPRESSION REGULATION; GENE VECTOR; GENETICS; METABOLISM; MYELOID LEUKEMIA; PATHOLOGY; TUMOR CELL LINE;

3' UNTRANSLATED REGIONS; ACUTE DISEASE; CELL DIFFERENTIATION; CELL LINE, TUMOR; CYCLIN-DEPENDENT KINASE INHIBITOR P15; DNA (CYTOSINE-5-)-METHYLTRANSFERASE; DNA METHYLATION; DOWN-REGULATION; ENZYME INDUCTION; ESTROGEN RECEPTOR ALPHA; GENE EXPRESSION REGULATION, LEUKEMIC; GENES, TUMOR SUPPRESSOR; GENETIC VECTORS; HUMANS; IMMUNODEFICIENCY VIRUS, FELINE; LEUKEMIA, MYELOID; MICRORNAS; NEOPLASM PROTEINS; NEOPLASTIC STEM CELLS; RNA, NEOPLASM; SP1 TRANSCRIPTION FACTOR;

EID: 67650588646     PISSN: 00064971     EISSN: 15280020     Source Type: Journal    
DOI: 10.1182/blood-2008-07-170589     Document Type: Article

References (30)

1. Galm O, Herman JG, Baylin SB. The fundamental role of epigenetics in hematopoietic malignancies. Blood Rev. 2006;20:1-13. (Pubitemid 43106714)
2. Jones PA, Baylin SB. The fundamental role of epigenetic events in cancer. Nat Rev Genet. 2002;3:415-428.
3. Toyota M, Kopecky KJ, Toyota MO, Jair KW, Willman CL, Issa JP. Methylation profiling in acute myeloid leukemia. Blood. 2001;97:2823-2829.
4. Mizuno S, Chijiwa T, Okamura T, et al. Expression of DNA methyltransferases DNMT1, 3A, and 3B in normal hematopoiesis and in acute and chronic myelogenous leukemia. Blood. 2001;97:1172-1179. (Pubitemid 32183737)
5. Saito Y, Liang G, Egger T, et al. Specific activation of microRNA-127 with downregulation of the proto-oncogene BCL6 by chromatin-modifying drugs in human cancer cells. Cancer Cell. 2006;9:435-443. (Pubitemid 43832188)
6. Fabbri M, Garzon R, Cimmino A, et al. MicroRNA-29 family reverts aberrant methylation in lung cancer by targeting DNA methyltransferases 3A and 3B. Proc Natl Acad Sci U S A. 2007;104:15805-15810. (Pubitemid 350035380)
7. Garzon R, Fabbri M, Cimmino A, Calin GA, Croce C. MicroRNA expression and function in cancer. Trends Mol Med. 2006;12:580-587.
8. Calin GA, Dumitru DC, Shimitzu M, et al. Frequent deletions and down-regulation of microRNA genes miR-15 and miR-16 at 13q14 in chronic lymphocytic leukemia. Proc Natl Acad Sci U S A. 2002;99:15524-15529.
9. Calin GA, Ferracin M, Cimmino A, et al. A microRNA signature associated with prognosis and progression in chronic lymphocytic leukemia. N Engl J Med. 2005;353:1793-1801. (Pubitemid 41549891)
10. Raveche ES, Salerno E, Scaglione BJ, et al. Abnormal microRNA-16 locus with synteny to human 13q14 linked to CLL in NZB mice. Blood. 2007;109:5079-5086. (Pubitemid 46890521)
11. Chen C, Ridzon DA, Broomer AJ, et al. Real-time quantification of microRNAs by stem-loop RT-PCR. Nucleic Acids Res. 2005;33:e179.
12. Garzon R, Volinia S, Liu CG, et al. MicroRNA signatures associated with cytogenetics and prognosis in acute myeloid leukemia. Blood. 2008;111:3183-3189.
13. Livak KJ, Schmittgen TD. Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C (T)) method. Methods. 2001;25:402-408. (Pubitemid 34164012)
14. Liu S, Liu Z, Xie Z, et al. Bortezomib induces DNA hypomethylation and silenced gene transcription by interfering with Sp1/NF-κB-dependent DNA methyltransferase activity in acute myeloid leukemia. Blood. 2008;111:2364-2373.
15. Liu Z, Liu S, Xie Z, et al. Characterization of in vitro and in vivo hypomethylating effects of decitabine in acute myeloid leukemia by a rapid, specific and sensitive LC-MS/MS method. Nucleic Acids Res. 2007;35:e31. (Pubitemid 46592893)
16. Ehrich M, Nelson MR, Stanssens P, et al. Quantitative high-throughput analysis of DNA methylation patterns by base-specific cleavage and mass spectrometry. Proc Natl Acad Sci U S A. 2005;102:15785-15790. (Pubitemid 41552820)
17. Pasquali L, Bedeir A, Ringquist S, Styche A, Bhargava R, Trucco G. Quantification of CpG island methylation in progressive breast lesions from normal to invasive carcinoma. Cancer Lett. 2007;257:136-144. (Pubitemid 47464705)
18. Krek A, Grün D, Poy MN, et al. Combinatorial microRNA target prediction. Nat Genet. 2005;37:495-500.
19. Lewis B, Shih I, Jones-Rhoades M, Bartel D, Burge C. Prediction of mammalian microRNA targets. Cell. 2003;115:787-798.
20. Kishikawa S, Murata T, Kimura H, Shiota K, Yokoyama KK. Regulation of transcription of the Dnmt1 gene by Sp1 and Sp3 zinc finger proteins. Eur J Biochem. 2002;269:2961-2970. (Pubitemid 34754025)
21. Issa JP, Zehnbauer BA, Civin CI, et al. The estrogen receptor CpG island is methylated in most hematopoietic neoplasms. Cancer Res. 1996;56:973-977.
22. Herman JG, Jen J, Merlo A, Baylin SB. Hypermethylation-associated inactivation indicates a tumor suppressor role for p15INK4B. Cancer Res. 1996;56:722-727. (Pubitemid 26060512)
23. Sakashita K, Koike K, Kinoshite T, et al. Dynamic DNA methylation change in the CpG island region of p15 during human myeloid development. J Clin Invest. 2001;108:1195-1204.
24. Black AR, Black JD, Azizkhan-Clifford J. Sp1 and krüppel-like factor family of transcription factors in cell growth regulation and cancer. J Cell Physiol. 2001;188:143-160. (Pubitemid 32622905)
25. Rhee I, Bachman KE, Park BH, et al. DNMT1 and DNMT3B cooperate to silence genes in human cancer cells. Nature. 2002;416:552-556. (Pubitemid 34288859)
26. Wolff L, Garin MT, Koller R, et al. Hypermethylation of the Ink4b locus in murine myeloid leukemia and increased susceptibility to leukemia in p15(Ink4b)-deficient mice. Oncogene. 2003;22:9265-9274. (Pubitemid 38122038)
27. Blum B, Klisovic R, Liu S, et al. Phase I study of decitabine alone or in combination with valproic acid treatment in acute myeloid leukemia. J Clin Oncol. 2007;25:3884-3891. (Pubitemid 47477265)
28. Koschmieder S, Agrawal S, Radomska HS, et al. Decitabine and vitamin D3 differentially affect hematopoietic transcription factors to induce monocytic differentiation. Int J Oncol. 2007;30:349-355.
29. Mott JL, Kobayashi S, Bronk SF, Gores GJ. Mir-29 regulates Mcl-1 protein expression and apoptosis. Oncogene. 2007;26:6133-6140. (Pubitemid 47414372)
30. Garzon R, Pichiorri F, Calin GA, et al. MicroRNA-29b targets MCL-1 and is down-regulated in chemotherapy-resistant acute myeloid leukemia (AML) [abstract]. Blood. 2007;110:717a.