Effects of sulforaphane and 3,3′-diindolylmethane on genome-wide promoter methylation in normal prostate epithelial cells and prostate cancer cells

PLoS ONE

Volumn 9, Issue 1, 2014, Pages

  Wong, Carmen P ^a,b   Hsu, Anna ^a,b   Buchanan, Alex ^a   Palomera Sanchez, Zoraya ^a,b   Beaver, Laura M ^a,b   Houseman, E Andres ^a   Williams, David E ^a,b   Dashwood, Roderick H ^a,b   Ho, Emily ^a,b  

^a OREGON STATE UNIVERSITY   (United States)

^b OREGON STATE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

3,3' DIINDOLYLMETHANE; DNA METHYLTRANSFERASE; SULFORAPHANE;

ARTICLE; CANCER CELL; CANCER CELL CULTURE; CANCER GROWTH; CONTROLLED STUDY; DNA METHYLATION; DRUG EFFECT; DRUG RESPONSE; HUMAN; HUMAN CELL; MALE; PROMOTER REGION; PROSTATE CANCER; PROSTATE EPITHELIUM; PROTEIN EXPRESSION;

ANALYSIS OF VARIANCE; ANTICARCINOGENIC AGENTS; CELLS, CULTURED; CHROMATIN IMMUNOPRECIPITATION; DNA METHYLATION; DNA PRIMERS; EPITHELIAL CELLS; HUMANS; INDOLES; ISOTHIOCYANATES; MALE; PROMOTER REGIONS, GENETIC; PROSTATE; PROSTATIC NEOPLASMS; REAL-TIME POLYMERASE CHAIN REACTION;

EID: 84898889926     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0086787     Document Type: Article

References (51)

1. Baylin SB, Jones PA (2011) A decade of exploring the cancer epigenome - biological and translational implications. Nat Rev Cancer 11: 726-734.
2. Portela A, Esteller M (2010) Epigenetic modifications and human disease. Nat Biotechnol 28: 1057-1068.
3. Denis H, Ndlovu MN, Fuks F (2011) Regulation of mammalian DNA methyltransferases: a route to new mechanisms. EMBO Rep 12: 647-656.
4. Mizuno S, Chijiwa T, Okamura T, Akashi K, Fukumaki Y, et al. (2001) Expression of DNA methyltransferases DNMT1, 3A, and 3B in normal hematopoiesis and in acute and chronic myelogenous leukemia. Blood 97: 1172-1179. (Pubitemid 32183737)
5. He S, Wang F, Yang L, Guo C, Wan R, et al. (2011) Expression of DNMT1 and DNMT3a are regulated by GLI1 in human pancreatic cancer. PLoS One 6: e27684.
6. Etoh T, Kanai Y, Ushijima S, Nakagawa T, Nakanishi Y, et al. (2004) Increased DNA methyltransferase 1 (DNMT1) protein expression correlates significantly with poorer tumor differentiation and frequent DNA hypermethylation of multiple CpG islands in gastric cancers. Am J Pathol 164: 689-699. (Pubitemid 38364682)
7. Lin RK, Wu CY, Chang JW, Juan LJ, Hsu HS, et al. (2010) Dysregulation of p53/Sp1 control leads to DNA methyltransferase-1 overexpression in lung cancer. Cancer Res 70: 5807-5817.
8. Morey Kinney SR, Smiraglia DJ, James SR, Moser MT, Foster BA, et al. (2008) Stage-specific alterations of DNA methyltransferase expression, DNA hypermethylation, and DNA hypomethylation during prostate cancer progression in the transgenic adenocarcinoma of mouse prostate model. Mol Cancer Res 6: 1365-1374.
9. Ho E, Beaver LM, Williams DE, Dashwood RH (2011) Dietary factors and epigenetic regulation for prostate cancer prevention. Adv Nutr 2: 497-510.
10. Li Y, Tollefsbol TO (2010) Impact on DNA methylation in cancer prevention and therapy by bioactive dietary components. Curr Med Chem 17: 2141-2151.
11. American Cancer Society (2012) Cancer Facts & Figures 2012. Atlanta: American Cancer Society.
12. Liu B, Mao Q, Cao M, Xie L (2012) Cruciferous vegetables intake and risk of prostate cancer: a meta-analysis. Int J Urol 19: 134-141.
13. Steinbrecher A, Nimptsch K, Husing A, Rohrmann S, Linseisen J (2009) Dietary glucosinolate intake and risk of prostate cancer in the EPIC-Heidelberg cohort study. Int J Cancer 125: 2179-2186.
14. Bradlow HL (2008) Review. Indole-3-carbinol as a chemoprotective agent in breast and prostate cancer. In Vivo 22: 441-445.
15. Clarke JD, Dashwood RH, Ho E (2008) Multi-targeted prevention of cancer by sulforaphane. Cancer Lett 269: 291-304.
16. Beaver LM, Yu TW, Sokolowski EI, Williams DE, Dashwood RH, et al. (2012) 3,3′-Diindolylmethane, but not indole-3-carbinol, inhibits histone deacetylase activity in prostate cancer cells. Toxicol Appl Pharmacol 263: 345-351.
17. Clarke JD, Hsu A, Yu Z, Dashwood RH, Ho E (2011) Differential effects of sulforaphane on histone deacetylases, cell cycle arrest and apoptosis in normal prostate cells versus hyperplastic and cancerous prostate cells. Mol Nutr Food Res 55: 999-1009.
18. Hsu A, Wong CP, Yu Z, Williams DE, Dashwood RH, et al. (2011) Promoter de-methylation of cyclin D2 by sulforaphane in prostate cancer cells. Clin Epigenetics 3: 3.
19. Meeran SM, Patel SN, Li Y, Shukla S, Tollefsbol TO (2012) Bioactive dietary supplements reactivate ER expression in ER-negative breast cancer cells by active chromatin modifications. PLoS One 7: e37748.
20. Meeran SM, Patel SN, Tollefsbol TO (2010) Sulforaphane causes epigenetic repression of hTERT expression in human breast cancer cell lines. PLoS One 5: e11457.
21. Anderton MJ, Manson MM, Verschoyle RD, Gescher A, Lamb JH, et al. (2004) Pharmacokinetics and tissue disposition of indole-3-carbinol and its acid condensation products after oral administration to mice. Clin Cancer Res 10: 5233-5241. (Pubitemid 39099798)
22. Myzak MC, Karplus PA, Chung FL, Dashwood RH (2004) A novel mechanism of chemoprotection by sulforaphane: inhibition of histone deacetylase. Cancer Res 64: 5767-5774. (Pubitemid 39095576)
23. Stein LD, Mungall C, Shu S, Caudy M, Mangone M, et al. (2002) The generic genome browser: a building block for a model organism system database. Genome Res 12: 1599-1610. (Pubitemid 35175099)
24. Saeed AI, Sharov V, White J, Li J, Liang W, et al. (2003) TM4: a free, opensource system for microarray data management and analysis. Biotechniques 34: 374-378. (Pubitemid 36184095)
25. Hulsen T, de Vlieg J, Alkema W (2008) BioVenn - a web application for the comparison and visualization of biological lists using area-proportional Venn diagrams. BMC Genomics 9: 488.
26. Huang da W, Sherman BT, Lempicki RA (2009) Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources. Nat Protoc 4: 44-57.
27. Halachev K, Bast H, Albrecht F, Lengauer T, Bock C (2012) EpiExplorer: live exploration and global analysis of large epigenomic datasets. Genome Biol 13: R96.
28. Palomera-Sanchez Z, Bucio-Mendez A, Valadez-Graham V, Reynaud E, Zurita M (2010) Drosophila p53 is required to increase the levels of the dKDM4B demethylase after UV-induced DNA damage to demethylate histone H3 lysine 9. J Biol Chem 285: 31370-31379.
29. Sandve GK, Gundersen S, Rydbeck H, Glad IK, Holden L, et al. (2010) The Genomic HyperBrowser: inferential genomics at the sequence level. Genome Biol 11: R121.
30. Sandve GK, Ferkingstad E, Nygard S (2011) Sequential Monte Carlo multiple testing. Bioinformatics 27: 3235-3241.
31. D'Antonio KB, Schultz L, Albadine R, Mondul AM, Platz EA, et al. (2010) Decreased expression of Cyr61 is associated with prostate cancer recurrence after surgical treatment. Clin Cancer Res 16: 5908-5913.
32. Kim IY, Ahn HJ, Zelner DJ, Shaw JW, Lang S, et al. (1996) Loss of expression of transforming growth factor beta type I and type II receptors correlates with tumor grade in human prostate cancer tissues. Clin Cancer Res 2: 1255-1261. (Pubitemid 26299422)
33. Terada N, Kulkarni P, Getzenberg RH (2012) Cyr61 is a potential prognostic marker for prostate cancer. Asian J Androl 14: 405-408.
34. Zhang Q, Rubenstein JN, Jang TL, Pins M, Javonovic B, et al. (2005) Insensitivity to transforming growth factor-beta results from promoter methylation of cognate receptors in human prostate cancer cells (LNCaP). Mol Endocrinol 19: 2390-2399. (Pubitemid 41252831)
35. Dubrovska A, Elliott J, Salamone RJ, Telegeev GD, Stakhovsky AE, et al. (2012) CXCR4 expression in prostate cancer progenitor cells. PLoS One 7: e31226.
36. Li JY, Ou ZL, Yu SJ, Gu XL, Yang C, et al. (2012) The chemokine receptor CCR4 promotes tumor growth and lung metastasis in breast cancer. Breast Cancer Res Treat 131: 837-848.
37. Sun YX, Wang J, Shelburne CE, Lopatin DE, Chinnaiyan AM, et al. (2003) Expression of CXCR4 and CXCL12 (SDF-1) in human prostate cancers (PCa) in vivo. J Cell Biochem 89: 462-473. (Pubitemid 36648768)
38. Yang YM, Feng AL, Zhou CJ, Liang XH, Mao HT, et al. (2011) Aberrant expression of chemokine receptor CCR4 in human gastric cancer contributes to tumor-induced immunosuppression. Cancer Sci 102: 1264-1271.
39. Consortium EP (2011) A user's guide to the encyclopedia of DNA elements (ENCODE). PLoS Biol 9: e1001046.
40. Bedford MT, van Helden PD (1987) Hypomethylation of DNA in pathological conditions of the human prostate. Cancer Res 47: 5274-5276. (Pubitemid 17152932)
41. Schulz WA, Elo JP, Florl AR, Pennanen S, Santourlidis S, et al. (2002) Genomewide DNA hypomethylation is associated with alterations on chromosome 8 in prostate carcinoma. Genes Chromosomes Cancer 35: 58-65. (Pubitemid 34847869)
42. Jeronimo C, Bastian PJ, Bjartell A, Carbone GM, Catto JW, et al. (2011) Epigenetics in prostate cancer: biologic and clinical relevance. Eur Urol 60: 753-766.
43. Lee C, Zhang Q, Zi X, Dash A, Soares MB, et al. (2012) TGF-beta mediated DNA methylation in prostate cancer. Transl Androl Urol 1(2): 78-88.
44. O'Hayre M, Salanga CL, Handel TM, Allen SJ (2008) Chemokines and cancer: migration, intracellular signalling and intercellular communication in the microenvironment. Biochem J 409: 635-649. (Pubitemid 351214190)
45. Vindrieux D, Escobar P, Lazennec G (2009) Emerging roles of chemokines in prostate cancer. Endocr Relat Cancer 16: 663-673.
46. Cho HJ, Seon MR, Lee YM, Kim J, Kim JK, et al. (2008) 3,3′-Diindolylmethane suppresses the inflammatory response to lipopolysaccharide in murine macrophages. J Nutr 138: 17-23.
47. Rajoria S, Suriano R, Wilson YL, Schantz SP, Moscatello A, et al. (2011) 3,3′-diindolylmethane inhibits migration and invasion of human cancer cells through combined suppression of ERK and AKT pathways. Oncol Rep 25: 491-497.
48. Shan Y, Zhang L, Bao Y, Li B, He C, et al. (2013) Epithelial-mesenchymal transition, a novel target of sulforaphane via COX-2/MMP2, 9/Snail, ZEB1 and miR-200c/ZEB1 pathways in human bladder cancer cells. J Nutr Biochem 24: 1062-1069.
49. Zhou J, Joplin DG, Cross JV, Templeton DJ (2012) Sulforaphane inhibits prostaglandin E2 synthesis by suppressing microsomal prostaglandin E synthase 1. PLoS One 7: e49744.
50. Sharma S, Kelly TK, Jones PA (2010) Epigenetics in cancer. Carcinogenesis 31: 27-36.
51. Zentner GE, Henikoff S (2013) Regulation of nucleosome dynamics by histone modifications. Nat Struct Mol Biol 20: 259-266.