Low prostate concentration of lycopene is associated with development of prostate cancer in patients with high-grade prostatic intraepithelial neoplasia

International Journal of Molecular Sciences

Volumn 15, Issue 1, 2014, Pages 1433-1440

  Mariani, Simone ^a,b   Lionetto, Luana ^a   Cavallari, Michele ^c   Tubaro, Andrea ^a,c   Rasio, Debora ^c   De Nunzio, Cosimo ^a   Hong, Gena M ^d   Borro, Marina ^a,c   Simmaco, Maurizio ^a,c  

^a SAPIENZA UNIVERSITY OF ROME   (Italy)

^b Fabia Mater Hospital   (Italy)

^c SAPIENZA UNIVERSITY OF ROME   (Italy)

^d BOSTON MEDICAL CENTER   (United States)

Author keywords

HGPIN; Lycopene; Prostate cancer; Prostatic lycopene

Indexed keywords

BIOLOGICAL MARKER; LYCOPENE; PROSTATE SPECIFIC ANTIGEN;

AGED; ARTICLE; CLINICAL ARTICLE; DIET SUPPLEMENTATION; DISEASE COURSE; FOLLOW UP; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; PREDICTIVE VALUE; PROSTATE BIOPSY; PROSTATE CANCER; PROSTATIC INTRAEPITHELIAL NEOPLASIA; PROSTATITIS; SENSITIVITY AND SPECIFICITY;

AGED; ANTICARCINOGENIC AGENTS; CAROTENOIDS; HUMANS; MALE; MIDDLE AGED; PROSTATIC INTRAEPITHELIAL NEOPLASIA; PROSTATIC NEOPLASMS;

EID: 84892873378     PISSN: 16616596     EISSN: 14220067     Source Type: Journal    
DOI: 10.3390/ijms15011433     Document Type: Article

References (21)

1. Ozten-Kandaş, N.; Bosland, M.C. Chemoprevention of prostate cancer: Natural compounds, antiandrogens, and antioxidants-In vivo evidence. J. Carcinog. 2011, 10, 27, doi:10.4103/1477-3163.90438.
2. Thapa, D.; Ghosh, R. Antioxidants for prostate cancer chemoprevention: Challenges and opportunities. Biochem. Pharmacol. 2012, 83, 1319-1330.
3. Shiota, M.; Yokomizo, A.; Naito, S. Pro-survival and anti-apoptotic properties of androgen receptor signaling by oxidative stress promote treatment resistance in prostate cancer. Endocr. Relat. Cancer 2012, 19, R243-R253.
4. Krinsky, N.I. The antioxidant and biological properties of the carotenoids. Ann. N.Y. Acad. Sci. 1998, 854, 443-447.
5. Park, Y.O.; Hwang, E.S.; Moon, T.W. The effect of lycopene on cell growth and oxidative DNA damage of Hep3B human hepatoma cells. Biofactors 2005, 23, 129-139.
6. Ivanov, N.I.; Cowell, S.P.; Brown, P.; Rennie, P.S.; Guns, E.S.; Cox, M.E. Lycopene differentially induces quiescence and apoptosis in androgen-responsive and -independent prostate cancer cell lines. Clin. Nutr. 2007, 26, 252-263.
7. Soares Nda, C.; Teodoro, A.J.; Oliveira, F.L.; Santos, C.A.; Takiya, C.M.; Junior, O.S.; Bianco, M.; Junior, A.P.; Nasciutti, L.E.; Ferreira, L.B. et al. Influence of lycopene on cell viability, cell cycle, and apoptosis of human prostate cancer and benign hyperplastic cells. Nutr. Cancer 2013, 65, 1076-1085.
8. Trejo-Solís, C.; Pedraza-Chaverrí, J.; Torres-Ramos, M.; Jiménez-Farfán, D.; Cruz Salgado, A.; Serrano-García, N.; Osorio-Rico, L.; Sotelo, J. Multiple molecular and cellular mechanisms of action of lycopene in cancer inhibition. Evid. Complement Alternat. Med. 2013, 2013, 705121.
9. Hantz, H.L.; Young, L.F.; Martin, K.R. Physiologically attainable concentrations of lycopene induce mitochondrial apoptosis in LNCaP human prostate cancer cells. Exp. Biol. Med. 2005, 230, 171-179.
10. Haseen, F.; Cantwell, M.M.; O'Sullivan, J.M.; Murray, L.J. Is there a benefit from lycopene supplementation in men with prostate cancer? A systematic review. Prostate Cancer Prostatic Dis. 2009, 12, 325-332.
11. Chen, L.; Stacewicz-Sapuntzakis, M.; Duncan, C.; Sharifi, R.; Ghosh, L.; van Breemen, R.; Ashton, D.; Bowen, P.E. Oxidative DNA damage in prostate cancer patients consuming tomato sauce-based entrees as a whole-food intervention. J. Natl. Cancer Inst. 2001, 93, 1872-1879.
12. Bowen, P.; Chen, L.; Stacewicz-Sapuntzakis, M.; Duncan, C.; Sharifi, R.; Ghosh, L.; Kim, H.S.; Christov-Tzelkov, K.; van Breemen, R. Tomato sauce supplementation and prostate cancer: Lycopene accumulation and modulation of biomarkers of carcinogenesis. Exp. Biol. Med. (Maywood) 2002, 227, 886-893.
13. Ilic, D.; Misso, M. Lycopene for the prevention and treatment of benign prostatic hyperplasia and prostate cancer: A systematic review. Maturitas 2012, 72, 269-276.
14. Wei, M.Y.; Giovannucci, E.L. Lycopene, Tomato products, and prostate cancer incidence: A review and reassessment in the PSA screening era. J. Oncol. 2012, doi:10.1155/2012/271063.
15. Taneja, S.S. Drug therapies for eradicating high-grade prostatic intraepithelial neoplasia in the prevention of prostate cancer. Rev. Urol. 2005, 7, S19-S29.
16. Hsing, A.W.; Comstock, G.W.; Abbey, H.; Polk, B.F. Serologic precursor of cancer. Retinol, carotenoids and tocopherol and risk of prostate cancer. J. Natl. Cancer Inst. 1990, 82, 941-946.
17. Gann, P.; Ma, J.; Giovannucci, E.; Willett, W.; Sacks, F.M.; Hennekens, C.H.; Stampfer, M.J. Lower prostate cancer risk in men with elevated plasma lycopene: Results of a prospective analysis. Cancer Res. 1999, 59, 1225-1230.
18. Rao, A.V. Serum and tissue lycopene and biomarkers of oxidation in prostate cancer patients: A case-control study. Nutr. Cancer 1999, 33, 159-164.
19. Ros, M.M.; Bueno-de-Mesquita, H.B.; Kampman, E.; Aben, K.K.; Büchner, F.L.; Jansen, E.H.; van Gils, C.H.; Egevad, L.; Overvad, K.; Tjønneland, A. et al. Plasma carotenoids and vitamin C concentrations and risk of urothelial cell carcinoma in the European Prospective Investigation into Cancer and Nutrition. Am. J. Clin. Nutr. 2012, 96, 902-910.
20. Hughes, K.J.; Mayne, S.T.; Blumberg, J.B.; Ribaya-Mercado, J.D.; Johnson, E.J.; Cartmel, B. Plasma carotenoids and biomarkers of oxidative stress in patients with prior head and neck cancer. Biomark Insights 2009, 23, 17-26.
21. Stahl, W.; Sies, H. Uptake of lycopene and its geometrical isomers is greater from heat-processed than from unprocessed tomato juice in humans. J. Nutr. 1992, 122, 2161-2166.