Epigenetic induction of tissue inhibitor of matrix metalloproteinase-3 by green tea polyphenols in breast cancer cells

Molecular Carcinogenesis

Volumn 54, Issue 6, 2015, Pages 485-499

  Deb, Gauri ^a,b   Thakur, Vijay S ^a,c   Limaye, Anil M ^b   Gupta, Sanjay ^a,c,d  

^a CASE WESTERN RESERVE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b INDIAN INSTITUTE OF TECHNOLOGY GUWAHATI   (India)

^c UNIVERSITY HOSPITALS OF CLEVELAND   (United States)

^d CASE WESTERN RESERVE UNIVERSITY   (United States)

Author keywords

Breast cancer; Enhancer of zeste homolog 2; Green tea polyphenols; Histone deacetylases; Invasion; Metastasis; Tissue inhibitors of matrix metalloproteinase 3

Indexed keywords

EPIGALLOCATECHIN GALLATE; GELATIN; GELATINASE A; GELATINASE B; GUANOSINE TRIPHOSPHATE; HISTONE DEACETYLASE 1; HISTONE H3; LYSINE; MESSENGER RNA; POLYPHENOL; TISSUE INHIBITOR OF METALLOPROTEINASE 3; TRANSCRIPTION FACTOR EZH2; CATECHIN; TEA;

ARTICLE; BREAST CANCER CELL LINE; CONTROLLED STUDY; DNA METHYLATION; ENZYME INDUCTION; EPIGENETICS; GENE REPRESSION; GENE SILENCING; HISTONE ACETYLATION; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; TEA; TRANSCRIPTION INITIATION; WOUND HEALING; ZYMOGRAPHY; ACETYLATION; ANALOGS AND DERIVATIVES; BREAST; BREAST NEOPLASMS; CHEMISTRY; DRUG EFFECTS; FEMALE; GENE EXPRESSION REGULATION; GENETIC EPIGENESIS; GENETICS; METABOLISM; PATHOLOGY; PROMOTER REGION; TUMOR CELL LINE;

ACETYLATION; BREAST; BREAST NEOPLASMS; CATECHIN; CELL LINE, TUMOR; DNA METHYLATION; EPIGENESIS, GENETIC; FEMALE; GENE EXPRESSION REGULATION, NEOPLASTIC; GENE SILENCING; HUMANS; POLYPHENOLS; PROMOTER REGIONS, GENETIC; TEA; TISSUE INHIBITOR OF METALLOPROTEINASE-3;

EID: 84926992337     PISSN: 08991987     EISSN: 10982744     Source Type: Journal    
DOI: 10.1002/mc.22121     Document Type: Article

References (53)

1. Siegel R, Naishadham D, Jemal A. Cancer statistics, 2013. CA Cancer J Clin 2013; 63:11-30.
2. Joyce JA, Pollard JW. Microenvironmental regulation of metastasis. Nat Rev Cancer 2009; 9:239-252.
3. Stetler-Stevenson WG, Aznavoorian S, Liotta LA. Tumor cell interactions with the extracellular matrix during invasion and metastasis. Ann Rev Cell Biol 1993; 9:541-573.
4. Friedl P, Wolf K. Tube travel: The role of proteases in individual and collective cancer cell invasion. Cancer Res 2008; 68:7247-7249.
5. Birkedal-Hansen H, Moore WGI, Bodden MK, et al. Matrix metalloproteinases: A review. Crit Rev Oral Biol Med 1993; 4:197-250.
6. Liotta LA, Tryggvason K, Garbisa S, Hart I, Foltz CM, Shafie S. Metastatic potential correlates with enzymatic degradation of basement membrane collagen. Nature 1980; 284:67-68.
7. Schor SL, Schor AM. Phenotypic and genetic alterations in mammary stroma: Implications for tumour progression. Breast Cancer Res 2001; 3:373-379.
8. Takafuji V, Forgues M, Unsworth E, Goldsmith P, Wang XW. An osteopontin fragment is essential for tumor cell invasion in hepatocellular carcinoma. Oncogene 2007; 26:6361-6371.
9. Johansson N, Ahonen M, Kahari VM. Matrix metalloproteinases in tumor invasion. Cell Mol Life Sci 2000; 57:5-15.
10. Bergers G, Brekken R, McMahon G, et al. Matrix metalloproteinase-9 triggers the angiogenic switch during carcinogenesis. Nat Cell Biol 2000; 2:737-744.
11. Fang J, Shing Y, Wiederschain D, et al. Matrix metalloproteinase-2 is required for the switch to the angiogenic phenotype in a tumor model. Proc Natl Acad Sci USA 2000; 97:3884-3889.
12. Visse R, Nagase H. Matrix metalloproteinases and tissue inhibitors of metalloproteinases: Structure, function, and biochemistry. Circ Res 2003; 92:827-839.
13. Cruz-Munoz W, Khokha R. The role of tissue inhibitors of metalloproteinases in tumorigenesis and metastasis. Crit Rev Clin Lab Sci 2008; 45:291-338.
14. Brew K, Nagase H. The tissue inhibitors of metalloproteinases (TIMPs): An ancient family with structural and functional diversity. Biochim Biophys Acta 2010; 1803:55-71.
15. Bode W, Fernandez-Catalan C, Grams F, et al. Insights into MMP-TIMP interactions. Ann N Y Acad Sci 1999; 878:73-91.
16. Imren S, Kohn DB, Shimada H, Blavier L, DeClerck YA. Overexpression of tissue inhibitor of metalloproteinases-2 retroviral-mediated gene transfer in vivo inhibits tumor growth and invasion. Cancer Res 1996; 56:2891-2895.
17. Watanabe M, Takahashi Y, Ohta T, Mai M, Sasaki T, Seiki M. Inhibition of metastasis in human gastric cancer cells transfected with tissue inhibitor of metalloproteinase 1 gene in nude mice. Cancer 1996; 77:1676-1680.
18. Khokha R, Zimmer MJ, Graham CH, Lala PK, Waterhouse P. Suppression of invasion by inducible expression of tissue inhibitor of metalloproteinase-1 (TIMP-1) in B16-F10 melanoma cells. J Natl Cancer Inst 1992; 84:1017-1022.
19. DeClerck YA, Perez N, Shimada H, Boone TC, Langley KE, Taylor SM. Inhibition of invasion and metastasis in cells transfected with an inhibitor of metalloproteinases. Cancer Res 1992; 52:701-708.
20. Wang M, Liu YE, Greene J, et al. Inhibition of tumor growth and metastasis of human breast cancer cells transfected with tissue inhibitor of metalloproteinase 4. Oncogene 1997; 14:2767-2774.
21. Mylona E, Magkou C, Giannopoulou I, et al. Expression of tissue inhibitor of matrix metalloproteinases (TIMP)-3 protein in invasive breast carcinoma: Relation to tumor phenotype and clinical outcome. Breast Cancer Res 2006; 8:R57.
22. Chambers AF, Matrisian LM. Changing views of the role of matrix metalloproteinases in metastasis. J Natl Cancer Inst 1997; 89:1260-1270.
23. Zhang L, Zhao L, Zhao D, et al. Inhibition of tumor growth and induction of apoptosis in prostate cancer cell lines by overexpression of tissue inhibitor of matrix metalloproteinase-3. Cancer Gene Ther 2010; 17:171-179.
24. Deng X, Bhagat S, Dong Z, Mullins C, Chinni SR, Cher M. Tissue inhibitor of metalloproteinase-3 induces apoptosis in prostate cancer cells and confers increased sensitivity to paclitaxel. Eur J Cancer 2006; 42:3267-3273.
25. Lui EL, Loo WT, Zhu L, Cheung MN. Chow, LW DNA hypermethylation of TIMP3 gene in invasive breast ductal carcinoma. Biomed Pharmacother 2005; 59:S363-S365.
26. Bachman KE, Herman JG, Corn PG, et al. Methylation-associated silencing of the tissue inhibitor of metalloproteinase-3 gene suggest a suppressor role in kidney, brain, and other human cancers. Cancer Res 1999; 59:798-802.
27. Shinojima T, Yu Q, Huang SK, et al. Heterogeneous epigenetic regulation of TIMP3 in prostate cancer. Epigenetics 2012; 7:1279-1289.
28. Wu AH, Yu MC, Tseng C-C, Hankin J, Pike MC. Green tea and risk of breast cancer in Asian Americans. Int J Cancer 2003; 106:574-579.
29. Zhang M, Holman CDAJ, Huang J-P, Xie X. Green tea and the prevention of breast cancer: A case-control study in Southeast China. Carcinogenesis 2007; 28:1074-1078.
30. Dreosti IE, Wargovich MJ, Yang CS. Inhibition of carcinogenesis by tea: The evidence from experimental studies. Crit Rev Food Sci Nutr 1997; 37:761-770.
31. Braicu C, Gherman C. Epigallocatechin gallate induce cell death and apoptosis in triple negative breast cancer cells Hs578T. J Drug Target 2013; 21:250-256.
32. Stuart EC, Jarvis RM, Rosengren RJ. In vitro mechanism of action for the cytotoxicity elicited by the combination of epigallocatechin gallate and raloxifene in MDA-MB-231 cells. Oncol Rep 2010; 24:779-785.
33. Kavanagh KT, Hafer LJ, Kim DW, et al. Green tea extracts decrease carcinogen-induced mammary tumor burden in rats and rate of breast cancer cell proliferation in culture. J Cell Biochem 2001; 82:387-398.
34. Sen T, Dutta A, Chatterjee A. Epigallocatechin-3-gallate (EGCG) downregulates gelatinase-B (MMP-9) by involvement of FAK/ERK/NFkappaB and AP-1 in the human breast cancer cell line MDA-MB-231. Anticancer Drugs 2010; 21:632-644.
35. Farabegoli F, Papi A, Orlandi M. (-)-Epigallocatechin-3-gallate down-regulates EGFR, MMP-2, MMP-9 and EMMPRIN and inhibits the invasion of MCF-7 tamoxifen-resistant cells. Biosci Rep 2011; 31:99-108.
36. Fang MZ, Wang Y, Ai N, et al. Tea polyphenol (-)-epigallocatechin-3-gallate inhibits DNA methyltransferase and reactivates methylation-silenced genes in cancer cell lines. Cancer Res 2003; 63:7563-7570.
37. Thakur VS, Gupta K, Gupta S. Green tea polyphenols causes cell cycle arrest and apoptosis in prostate cancer cells by suppressing class I histone deacetylases. Carcinogenesis 2012; 33:377-384.
38. Shin YJ, Kim JH. The role of EZH2 in the regulation of the activity of matrix metalloproteinases in prostate cancer cells. PLoS ONE 2012; 7:e30393.
39. Paz MF, Fraga MF, Avila S, et al. A systematic profile of DNA methylation in human cancer cell lines. Cancer Res 2003; 63:1114-1121.
40. Komashko VM, Farnham PJ. 5-Azacytidine treatment reorganizes genomic histone modification patterns. Epigenetics 2010; 5:229-240.
41. Deb G, Thakur VS, Gupta S. Multifaceted role of EZH2 in breast and prostate tumorigenesis: Epigenetics and beyond. Epigenetics 2013; 8:464-476.
42. Collett K, Eide GE, Arnes J, et al. Expression of enhancer of zeste homologue 2 is significantly associated with increased tumor cell proliferation and is a marker of aggressive breast cancer. Clin Cancer Res 2006; 12:1168-1174.
43. Bachmann IM, Halvorsen OJ, Collett K, et al. EZH2 expression is associated with high proliferation rate and aggressive tumor subgroups in cutaneous melanoma and cancers of the endometrium, prostate, and breast. J Clin Oncol 2006; 24:268-273.
44. Yang X, Karuturi RK, Sun F, et al. CDKN1C (p57) is a direct target of EZH2 and suppressed by multiple epigenetic mechanisms in breast cancer cells. PLoS ONE 2009; 4:e5011.
45. Fujii S, Ito K, Ito Y, Ochiai A. Enhancer of zeste homologue 2 (EZH2) down-regulates RUNX3 by increasing histone H3 methylation. J Biol Chem 2008; 283:17324-17332.
46. Stearns V, Zhou Q, Davidson NE. Epigenetic regulation as a new target for breast cancer therapy. Cancer Invest 2007; 25:659-665.
47. Balasubramanian S, Adhikary G, Eckert RL. The Bmi-1 polycomb protein antagonizes the (-)-epigallocatechin-3-gallate-dependent suppression of skin cancer cell survival. Carcinogenesis 2010; 31:496-503.
48. Choudhury SR, Balasubramanian S, Chew YC, Han B, Marquez VE, Eckert RL. (-)-Epigallocatechin-3-gallate and DZNep reduce polycomb protein level via a proteasome-dependent mechanism in skin cancer cells. Carcinogenesis 2011; 32:1525-1532.
49. Thakur VS, Gupta K, Gupta S. The chemopreventive and chemotherapeutic potentials of tea polyphenols. Curr Pharm Biotechnol 2012; 13:191-199.
50. Sen T, Moulik S, Dutta A, et al. Multifunctional effect of epigallocatechin-3-gallate (EGCG) in downregulation of gelatinase-A (MMP-2) in human breast cancer cell line MCF-7. Life Sci 2009; 84:194-204.
51. Kato K, Long NK, Makita H, et al. Effects of green tea polyphenol on methylation status of RECK gene and cancer cell invasion in oral squamous cell carcinoma cells. Br J Cancer 2008; 99:647-654.
52. Singer CF, Kronsteiner N, Marton E, et al. MMP-2 and MMP-9 expression in breast cancer-derived human fibroblasts is differentially regulated by stromal-epithelial interactions. Breast Cancer Res Treat 2002; 72:69-77.
53. Kleiner DE, Stetler-Stevenson WG. Quantitative zymography: Detection of picogram quantities of gelatinases. Anal Biochem 1994; 218:325-329.