3,3'-Diindolylmethane, but not indole-3-carbinol, inhibits histone deacetylase activity in prostate cancer cells

Toxicology and Applied Pharmacology

Volumn 263, Issue 3, 2012, Pages 345-351

  Beaver, Laura M ^a,b   Yu, Tian Wei ^a   Sokolowski, Elizabeth I ^b   Williams, David E ^a,b   Dashwood, Roderick H ^a,b   Ho, Emily ^a,b  

^a OREGON STATE UNIVERSITY   (United States)

^b OREGON STATE UNIVERSITY   (United States)

Author keywords

3,3' Diindolylmethane; Chemoprevention; Epigenetics; Histone deacetylase; Indole 3 carbinol; Prostate cancer

Indexed keywords

3 INDOLEMETHANOL; 3,3' DIINDOLYLMETHANE; ANDROGEN; HISTONE; HISTONE DEACETYLASE; HISTONE DEACETYLASE 1; HISTONE DEACETYLASE 3; HISTONE DEACETYLASE 4; HISTONE DEACETYLASE 6; HISTONE DEACETYLASE 8; PROTEIN P21;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER CELL; CARCINOGENESIS; CELL CYCLE ARREST; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME INHIBITION; HISTONE ACETYLATION; HUMAN; HUMAN CELL; PROSTATE CANCER; PROTEIN EXPRESSION;

ANDROGENS; ANTICARCINOGENIC AGENTS; CELL LINE, TUMOR; CELL PROLIFERATION; CYCLIN-DEPENDENT KINASE INHIBITOR P21; GENE EXPRESSION REGULATION, NEOPLASTIC; HISTONE DEACETYLASE 2; HISTONE DEACETYLASE INHIBITORS; HISTONE DEACETYLASES; HUMANS; INDOLES; MALE; PROSTATIC NEOPLASMS;

EID: 84865429801     PISSN: 0041008X     EISSN: 10960333     Source Type: Journal    
DOI: 10.1016/j.taap.2012.07.007     Document Type: Article

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