Cancer prevention and treatment with resveratrol: From rodent studies to clinical trials

Cancer Prevention Research

Volumn 2, Issue 5, 2009, Pages 409-418

  Bishayee, Anupam ^a  

^a NORTHEAST OHIO MEDICAL UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

FLUOROURACIL; GENISTEIN; RESVERATROL; ANTINEOPLASTIC AGENT; STILBENE DERIVATIVE;

ANTINEOPLASTIC ACTIVITY; BREAST CANCER; CANCER PREVENTION; CHEMOPROPHYLAXIS; CLINICAL TRIAL; DIET SUPPLEMENTATION; DRUG BIOAVAILABILITY; DRUG MECHANISM; GASTROINTESTINAL TUMOR; GROWTH INHIBITION; HUMAN; IN VIVO STUDY; INCIDENCE; LUNG TUMOR; NEUROBLASTOMA; NONHUMAN; PRIORITY JOURNAL; PROSTATE ADENOCARCINOMA; REVIEW; RODENT; SKIN CARCINOGENESIS; ANIMAL; NEOPLASM;

ANIMALS; ANTINEOPLASTIC AGENTS; CLINICAL TRIALS AS TOPIC; HUMANS; NEOPLASMS; STILBENES;

EID: 67650297506     PISSN: 19406207     EISSN: None     Source Type: Journal    
DOI: 10.1158/1940-6207.CAPR-08-0160     Document Type: Review

References (75)

1. Baur JA, Sinclair DA. Therapeutic potential of resveratrol: the in vivo evidence. Nat Rev Drug Discov 2006;5:493-506. (Pubitemid 44136961)
2. Saiko P, Szakmary A, Jaeger W, Szekeres T. Resveratrol and its analogs: defense against cancer, coronary disease and neurodegenerative maladies or just a fad?. Mutat Res 2008;658:68-94. (Pubitemid 351172881)
3. Harikumar KB, Aggarwal BB. Resveratrol. A multitargeted agent for age-associated chronic diseases. Cell Cycle 2008;7:1020-1037
4. Shishodia S, Aggarwal BB. Resveratrol: a polyphenol for all seasons. In: Aggarwal BB, Shishodia S, editors. Resveratrol in health and disease. Boca Raton: CRC Press; 2006. p. 1-16.
5. Kopp P. Resveratrol, a phytoestrogen found in red wine. A possible explanation for the conundrum of the 'French paradox'? Eur J Endocrinol 1998;138:619-620
6. Baur JA, Pearson KJ, Price NL, et al. Resveratrol improves health and survival of mice on a high-calorie diet. Nature 2006;444:337-342
7. Lagouge M, Argmann C, Gerhart-Hines Z, et al. Resveratrol improves mitochondrial function and protects against metabolic disease by activating SIRT1 and PGC-1α. Cell 2006;127:1109-1122 (Pubitemid 44894520)
8. Pezzuto JM, Kondratyuk T, Shalaev E. Cancer chemoprevention by wine polyphenols and resveratrol. In: Baer-Dubowska W, Brtoszek A, Malejka-Giganti D, editors. Carcinogenic and anticarcinogenic food components. Boca Raton: CRC Press; 2006. p. 239-282
9. Aggarwal BB, Bhardwaj A, Aggarwal RS, Seeram NP, Shishodia S, Takada Y. Role of resveratrol in prevention and therapy of cancer: preclinical and clinical studies. Anticancer Res 2004;24:2783-2840 (Pubitemid 39409568)
10. Shankar S, Singh G, Srivastava RK. Chemoprevention by resveratrol: molecular mechanisms and therapeutic potential. Front Biosci 2007;12:4839-4854
11. Kundu JK, Surh Y-J. Cancer chemopreventive and therapeutic potential of resveratrol: mechanistic perspectives. Cancer Lett 2008;269:243-261
12. Jang M, Cai L, Udeani GO, et al. Cancer chemopreventive activity of resveratrol, a natural product derived from grapes. Science 1997;275:218-220 (Pubitemid 127696281)
13. Jang M, Pezzuto JM. Effects of resveratrol on 12-O-tetradecanoylphorbol- 13-acetate-induced oxidative events and gene expression in mouse skin. Cancer Lett 1998;134:81-89 (Pubitemid 29070853)
14. Kapadia GJ, Azuine MA, Tokuda H, et al. Chemopreventive effect of resveratrol, sesamol, sesame oil and sunflower oil in the Epstein-Barr virus early antigen activation assay and the mouse skin two-stage carcinogenesis. Pharmacol Res 2002;45:499-505. (Pubitemid 35304500)
15. Soleas GJ, Grass L, Josephy PD, Goldberg DM, Diamandis EP. A comparison of the anticarcinogenic properties of four red wine polyphenols. Clin Biochem 2002;35:119-124 (Pubitemid 34442691)
16. Kalra N, Roy P, Prasad S, Shukla Y. Resveratrol induces apoptosis involving mitochondrial pathways in mouse skin tumorigenesis. Life Sci 2008;82:348-358
17. Afaq F, Adhami VM, Ahmad N. Prevention of short-term ultraviolet B radiation-mediated damages by resveratrol in SKH-1 hairless mice. Toxicol Appl Pharmacol 2003;186:28-37. (Pubitemid 36262946)
18. Reagan-Shaw S, Afaq F, Aziz MH, Ahmad N. Modulation of critical cell cycle regulatory events during chemoprevention of ultraviolet B-mediated responses by resveratrol in SKH-1 hairless mouse skin. Oncogene 2004;23:5151-5160 (Pubitemid 38980348)
19. Aziz MH, Afaq F, Ahmad N. Prevention of ultraviolet-B radiation damage by resveratrol in mouse skin is mediated via modulation in survivin. Photochem Photobiol 2005;81:25-31. (Pubitemid 40327556)
20. Aziz MH, Reagan-Shaw S, Wu J, Longley BJ, Ahmad N. Chemoprevention of skin cancer by grape constituent resveratrol: relevance to human disease?. FASEB J 2005;19:1193-1195 (Pubitemid 40946462)
21. Caltagirone S, Rossi C, Poggi A, et al. Flavonoids apigenin and quercetin inhibit melanoma growth and metastatic potential. Int J Cancer 2000;87:595-600. (Pubitemid 30639822)
22. Asensi M, Medina I, Ortega A, et al. Inhibition of cancer growth by resveratrol is related to its low bioavailability. Free Rad Biol Med 2002;33:387-398 (Pubitemid 34786278)
23. Niles RM, Cook CP, Meadows GG, Fu Y-M, McLaughlin JL, Rankin GO. Resveratrol is rapidly metabolized in athymic (Nu/Nu) mice and does not inhibit human melanoma xenograft tumor growth. J Nutr 2006;136:2542-2546
24. Banerjee S, Bueso-Ramos C, Aggarwal BB. Suppression of 7,12-dimethylbenz(a)anthracene-induced mammary carcinogenesis in rats by resveratrol: role of nuclear factor-κB, cyclooxygenase 2, and matrix metalloprotease 9. Cancer Res 2002;62:4945-4954
25. Whitsett T, Carpenter M, Lamartiniere CA. Resveratrol, but not EGCG, in the diet suppresses DMBA-induced mammary cancer in rats. J Carcinog 2006;5:15. (Pubitemid 44150682)
26. Whitsett TG, Jr., Lamartiniere CA. Genistein and resveratrol: mammary cancer chemoprevention and mechanisms of action in the rat. Expert Rev Anticancer Ther 2006;6:1699-1706 (Pubitemid 46062304)
27. Bhat KLP, Lantvit D, Christov K, Mehta RG, Moon RC, Pezzuto JM. Estrogenic and antiestrogenic properties of resveratrol in mammary tumor models. Cancer Res 2001;61:7456-7463 (Pubitemid 32995034)
28. Sato M, Per R-J, Yuri T, Danbara N, Nakane Y, Tsubura A. Prepubertal resveratrol exposure accelerates N-methyl-N-nitrosourea-induced mammary carcinoma in female Sprague-Dawley rats. Cancer Lett 2003;202:137-145 (Pubitemid 37485886)
29. Garvin S, Öllinger K, Dabrosin C. Resveratrol induces apoptosis and inhibits angiogenesis in human breast cancer xenografts in vivo. Cancer Lett 2006;231:113-122 (Pubitemid 41779459)
30. Bove K, Lincoln DW, Tsan M-F. Effect of resveratrol on growth of 4T1 breast cancer cells in vitro and in vivo. Biochem Biophys Res Commun 2002;291:1001-1005
31. Provinciali M, Re F, Donnini A, et al. Effect of resveratrol on the development of spontaneous mammary tumors in HER-2/neu transgenic mice. Int J Cancer 2005;115:36-45. (Pubitemid 40559666)
32. Schlachterman A, Valle F, Wall KM, et al. Combined resveratrol, quercetin, and catechin treatment reduces breast tumor growth in a nude mouse model. Translational Oncol 2008;1:19-27.
33. Harper CE, Patel BB, Wang J, Arabshahi A, Eltoum IA, Lamartiniere CA. Resveratrol suppresses prostate cancer progression in transgenic mice. Carcinogenesis 2007;28:1946-1953 (Pubitemid 47500607)
34. Seeni A, Takahashi S, Takeshita K, et al. Suppression of prostate cancer growth by resveratrol in the transgenic rat for adenocarcinoma of pros- tate (TRAP) model. Asian Pac J Cancer Prev 2008;9:7-14.
35. CIP expression. Carcinogenesis 2000;21:1619-1622 (Pubitemid 30608219)
36. Sengottuvelan M, Viswanathan P, Nalini N. Chemopreventive effect of trans-resveratrol - a phytoalexin against colonic aberrant crypt foci and cell proliferation in 1,2-dimethylhydrazine induced coion carcinogenesis. Carcinogenesis 2006;27:1038-1046
37. Sengottuvelan M, Senthilkumar R, Nalini N. Modulatory influence of dietary resveratrol during different phases of 1,2-dimethylhydrazine induced mucosal lipid-peroxidation, antioxidant status and aberrant crypt foci development in rat colon carcinogenesis. Biochim Biophys Acta 2006;1760:1175-1183 (Pubitemid 43928257)
38. Sengottuvelan M, Nalini N. Dietary supplementation of resveratrol suppresses colonic tumour incidence in 1,2-dimethylhydrazine-treated rats by modulating biotransforming enzymes and aberrant crypt foci development. Br J Nutr 2006;96:145-153 (Pubitemid 44160908)
39. Schneider Y, Duranton B, Gösse F, Schleiffer R, Seiler N, Raul F. Resveratrol inhibits intestinal tumorigenesis and modulates host-defense- regulated gene expression in an animal model of human familial adenomatous polyposis. Nutr Cancer 2001;39:102-107 (Pubitemid 32880955)
40. Min/+ mouse and cycloooygenase-2 in human-derived colon cancer cells. Int J Cancer 2005;115:194-201.
41. Min/+ mice. J Nutr 2004;134:5-10. (Pubitemid 38057415)
42. Li ZG, Hong T, Shimada Y, et al. Suppression of N- nitrosomethylbenzylamine (NMBA)-induced esophageal tumorigenesis in F344 rats by resveratrol. Carcinogenesis 2002;23:1531-1536 (Pubitemid 35012434)
43. Zhou H-B, Chen J-J, Wang W-X, Cai J-T, Du Q. Anticancer activity of resveratrol on implanted human primary gastric carcinoma cells in nude mice. World J Gastroenterol 2005;11:280-284 (Pubitemid 40125220)
44. Kuroiwa Y, Nishikawa A, Kitamura Y, et al. Protective effects of benzyl isothiocyanate and sulforaphane but not resveratrol against initiation of pancreatic carcinogenesis in hamsters. Cancer Lett 2006;241:275-280 (Pubitemid 44163037)
45. Carbó N, Costelli P, Baccino FM, López-Soriano FJ, Argilés JM. Resveratrol, a natural product present in wine, decreases tumour growth in a rat tumour model. Biochem Biophys Res Commun 1999;254:739-743
46. Miura D, Miura Y, Yagasaki K. Hypolipidemic action of dietary resveratrol, a phytoalexin in grapes and red wine, in hepatoma-bearing rats. Life Sci 2003;73:1393-1400 (Pubitemid 36798126)
47. Liu H-S, Pan C-E, Yang W, Liu X-M. Antitumor and immunomodulatory activity of resveratrol on experimentally implanted tumor of H22 in Balb/c mice. World J Gastroenterol 2003;9:1474-1476 (Pubitemid 36992335)
48. Yu L, Sun Z-J, Wu S-L, Pan C-E. Effect of resveratrol on cell cycle proteins in murine transplantable liver cancer. World J Gastroenterol 2003;9:2341-2343 (Pubitemid 37321474)
49. Wu S-L, Sun Z-J, Yu L, Meng K-W, Qin X-L, Pan C-E. Effect of resveratrol and in combination with 5-FU on murine liver cancer. World J Gastroenterol 2004;10:3048-3052 (Pubitemid 39303061)
50. Bishayee A, Dhir N. Resveratrol-mediated chemoprevention of diethylnitrosamine-initiated hepatocarcinogenesis: inhibition of cell proliferation and induction of apoptosis. Chem-Biol Interact 2009;179:131-144
51. Hecht SS, Kenney PMJ, Wang M, et al. Evaluation of butylated hydroxyanisole, myo-inositol, curcumin, esculetin, resveratrol and lycopene as inhibitors of benzo[a]pyrene plus 4-(methylnitrosamino)-1-(3-pyridyl)-1- butanone-induced lung tumorigenesis in A/J mice. Cancer Lett 1999;137:123-130 (Pubitemid 29179454)
52. Berge G, Øvrebø S, Haugen A, Mollerup S. Analysis of resveratrol as a lung cancer chemopreventive agent in A/J mice exposed to benzo[a]pyrene. Br J Cancer 2004;91:1380-1383
53. Kimura Y, Okuda H. Resveratrol isolated from Polygonum cuspidatum root prevents tumor growth and metastasis to lung and tumor-induced neovascularization in Lewis lung carcinoma-bearing mice. J Nutr 2001;131:1844-1849 (Pubitemid 32520456)
54. Busquets S, Ametller E, Fuster G, et al. Resveratrol, a natural diphenol, reduces metastatic growth in an experimental cancer model. Cancer Lett 2007;245:144-148
55. Lee E-O, Lee H-J, Hwang H-S, et al. Potent inhibition of Lewis lung cancer growth by heyneanol A from the roots of Vitis amurensis through apoptotic and anti-angiogenic activities. Carcinogenesis 2006;27:2059-2069
56. Chen Y, Tseng S-H, Lai H-S, Chen W-J. Resveratrol-induced cellular apoptosis and cell cycle arrest in neuroblastoma cells and antitumor effects on neuroblastoma in mice. Surgery 2004;136:57-66. (Pubitemid 38834220)
57. Tseng S-H, Lin S-M, Chen J-C, et al. Resveratrol suppresses the angiogenesis and tumor growth of gliomas in rats. Clin Cancer Res 2004;10:2190-2202 (Pubitemid 38375581)
58. Chen J-C, Chen Y, Lin J-H, Wu J-M, Tseng S-H. Resveratrol suppresses angiogenesis in gliomas: evaluation by color Doppler ultrasound. Anticancer Res 2006;26:1237-1246
59. van Ginkel PR, Sareen D, Subramanian L, et al. Resveratrol inhibits tumor growth of human neuroblastoma and mediates apoptosis by directly targeting mitochondria. Clin Cancer Res 2007;13:5162-5169 (Pubitemid 47502085)
60. Gao X, Xu YX, Divine G, Janakiraman N, Chapman RA, Gautam SC. Disparate in vitro and in vivo antileukemic effects of resveratrol, a natural polyphenols compound found in grapes. Nutr Cancer 2002;132:2076-2081 (Pubitemid 34742903)
61. Li T, Fan G-X, Wang W, Yuan Y-K. Resveratrol induces apoptosis, influences IL-6 and exerts immunomodulatory effects on mouse lymphocytic leukemia both in vitro and In vivo. Int Immunopharmacol 2007;7:1221-1231 (Pubitemid 47042639)
62. Brȧkenhielm E, Cao R, Cao Y. Suppression of angiogenesis, tumor growth, and wound healing by resveratrol, a natural compound in red wine and grapes. FASEB J 2001;15:1798-1800
63. van Ginkel PR, Darjatmoko SR, Sareen D, et al. Resveratrol inhibits uveal melanoma tumor growth via early mitochondrial dysfunction. Invest Ophthalmol Vis Sci 2008;49:1299-1306
64. Soleas GJ, Yan J, Goldberg DM. Ultrasensitivity assay for the three polyphenols (catechin, quercetin and resveratrol) and their conjugates in biological fluids utilizing gas chromatography with mass selective detection. J Chromatogr B 2002;757:161-172 (Pubitemid 32424469)
65. Goldberg DM, Yan J, Soleas GJ. Absorption of three wine-related polyphenols in three different matrices by healthy subjects. Clin Biochem 2003;36:79-87.
66. Walle T, Hsieh F, DeLegge MH, Oatis JE, Walle UK. High absorption but very low bioavailability of oral resveratrol in humans. Drug Metab Disp 2004;32:1377-1382
67. Meng X, Maliaki P, Lu H, Lee M-J, Yang CS. Urinary and plasma levels of resveratrol and quercetin in humans, mice, and rats after ingestion of pure compounds and grape juice. J Agric Food Chem 2004;52:935-942
68. Boocock DJ, Patel KR, Faust GES, et al. Quantitation of trans-resveratrol and detection of its metabolites in human plasma and urine by high performance liquid chromatography. J Chromatogr B 2007;848:182-187 (Pubitemid 46464044)
69. Boocock DJ, Faust GES, Patel KR, et al. Phase I dose escalation pharmacokinetic study in healthy volunteers of resveratrol, a potential cancer chemopreventive agent. Cancer Epidemiol Biomarkers Prev 2007;16:1246-1252
70. Vitaglione P, Sforza S, Galavema G, et al. Bioavailability of trans-resveratrol from red wine in humans. Mol Nutr Food Res 2005;49:495-504. (Pubitemid 40780396)
71. Zamora-Ross R, Urpi-Sardà M, Lamuela-Raventós RM, et al. Diagnostic performance of urinary resveratrol metabolites as a biomarker of moderate wine consumption. Clin Chem 2006;52:1373-1380
72. Levi F, Pasche C, Lucchini F, Ghidoni R, Ferraroni M, La Vecchia C. Resveratrol and breast cancer risk. Eur J Cancer Prev 2005;14:139-142
73. Suh N, Paul S, Hao X, et al. Pterostilbene, an active constituent of blueberries, suppresses aberrant crypt foci formation in the azoxymethane-induced colon carcinogenesis model in rats. Clin Cancer Res 2007;13:350-355 (Pubitemid 46121889)
74. Shibata M-A, Akao Y, Shibata E, et al. Vaticanol C, a novel resveratrol tetramer, reduces lymph node and lung metastases of mouse mammary carcinoma carrying p53 mutation. Cancer Chemother Pharmacol 2007;60:681-691 (Pubitemid 47247280)
75. Pan M-H, Gao J-H, Lai C-S, et al. Antitumor activity of 3,5,4′-trimethoxystilbene in COLO 205 cells and xenografts in SCID mice. Mol Carcinog 2008;47:184-196