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Volumn 64, Issue , 2010, Pages 590-603

Sulforaphane - A possible agent in prevention and therapy of cancer;Sulforafan - Potencjalny czynnik w prewencji i terapii chorób nowotworowych

Author keywords

Bioavailability; Cancer chemoprevention; Metabolism; Sulforaphane

Indexed keywords

ANTINEOPLASTIC AGENT; SULFORAFAN; THIOCYANIC ACID DERIVATIVE;

EID: 79952723845     PISSN: 00325449     EISSN: 17322693     Source Type: Journal    
DOI: None     Document Type: Review
Times cited : (19)

References (104)
  • 1
    • 2442587889 scopus 로고    scopus 로고
    • Breast Cancer Risk in Premenopausal Women Is Inversely Associated with Consumption of Broccoli, a Source of Isothiocyanates, but Is Not Modified by GST Genotype
    • Ambrosone C. B., McCann S. E., Freudenheim J. L., Marshall J. R., Zhang Y., Shields P. G.: Breast cancer risk in premenopausal women in inversely associated with consumption of broccoli, a source of isothiocyanates, but is modified by GST genotype. J. Nutr., 2004;134:1134-1138 (Pubitemid 38619952)
    • (2004) Journal of Nutrition , vol.134 , Issue.5 , pp. 1134-1138
    • Ambrosone, C.B.1    McCann, S.E.2    Freudenheim, J.L.3    Marshall, J.R.4    Zhang, Y.5    Shields, P.G.6
  • 3
    • 0346888660 scopus 로고    scopus 로고
    • Sulforaphane and quercetin modulate PhIP-DNA adduct formation in human HepG2 cells and hepatocytes
    • DOI 10.1093/carcin/bgg157
    • Bacon J. R., Williamson G., Garner R. C., Lappin G., Langouet S., Bao Y.: Sulforaphane and quercetin modulate PhIP-DNA adduct formation in human HepG2 cells and hepatocytes. Carcinogenesis, 2003;24:1903-1911 (Pubitemid 38008530)
    • (2003) Carcinogenesis , vol.24 , Issue.12 , pp. 1903-1911
    • Bacon, J.R.1    Williamson, G.2    Garner, R.C.3    Lappin, G.4    Langouet, S.5    Bao, Y.6
  • 4
    • 22044433408 scopus 로고    scopus 로고
    • NF-B, Nrf2, and HO-1 interplay in redox-regulated VCAM-1 expression
    • DOI 10.1089/ars.2005.7.889
    • Banning A., Brigelius-Flohe R.: NF-kappaB, Nrf2, and HO-1 interplay in redox-regulated VCAM-1 expression. Antioxid. Redox. Signal., 2005;7:889-899 (Pubitemid 40967140)
    • (2005) Antioxidants and Redox Signaling , vol.7 , Issue.7-8 , pp. 889-899
    • Banning, A.1    Brigelius-Flohe, R.2
  • 5
    • 0029879994 scopus 로고    scopus 로고
    • CYP2E1-mediated mechanism of anti-genotoxicity of the broccoli constituent sulforaphane
    • DOI 10.1093/carcin/17.2.277
    • Barcelo S., Gardiner J. M., Gescher A., Chipman J. K.: CYP2E1-mediated mechanism of anti-genotoxicity of the broccoli constituent sulforaphane. Carcinogenesis, 1996;17:277-282 (Pubitemid 26091306)
    • (1996) Carcinogenesis , vol.17 , Issue.2 , pp. 277-282
    • Barcelo, S.1    Gardiner, J.M.2    Gescher, A.3    Chipman, J.K.4
  • 6
    • 0036045433 scopus 로고    scopus 로고
    • Sulforaphane and its glutathione conjugate but not sulforaphane nitrile induce UDP-glucuronosyl transferase (UGT1A1) and glutathione transferase (GSTA1) in cultured cells
    • Basten G. P., Bao Y., Williamson G.: Sulforaphane and its glutathione conjugate but not sulforaphane nitrile induce UDP-glucuronosyl transferase (UGT1A1) and glutathione transferase (GSTA1) in cultured cells. Carcinogenesis, 2002;23:1399-1404
    • (2002) Carcinogenesis , vol.23 , pp. 1399-1404
    • Basten, G.P.1    Bao, Y.2    Williamson, G.3
  • 7
    • 33645472584 scopus 로고    scopus 로고
    • Inhibition of angiogenesis and endothelial cell functions are novel sulforaphane-mediated mechanisms in chemoprevention
    • Bertl E., Bartsch H., Gerhauser C: Inhibition of angiogenesis and endothelial cell functions are novel sulforaphane-mediated mechanisms in chemoprevention. Mol. Cancer Ther., 2006;5:575-585
    • (2006) Mol. Cancer Ther. , vol.5 , pp. 575-585
    • Bertl, E.1    Bartsch, H.2    Gerhauser, C.3
  • 8
    • 34247626240 scopus 로고    scopus 로고
    • The metabolic fate of purified glucoraphanin in F344 rats
    • DOI 10.1021/jf0633544
    • Bheemreddy R. M., Jeffery E. H.: The metabolic fate of purified glucoraphanin in F344 rats. J. Agric. Food Chem., 2007;55:2861-2866 (Pubitemid 46668290)
    • (2007) Journal of Agricultural and Food Chemistry , vol.55 , Issue.8 , pp. 2861-2866
    • Bheemreddy, R.M.1    Jeffery, E.H.2
  • 9
    • 0035881570 scopus 로고    scopus 로고
    • Dietary indoles and isothiocyanates that are generated from cruciferous vegetables can both stimulate apoptosis and confer protection against DNA damage in human colon cell lines
    • Bonnesen C, Eggleston I. M., Hayes J. D.: Dietary indoles and isothiocyanates that are generated from cruciferous vegetables can both stimulate apoptosis and confer protection against DNA damage in human colon cell lines. Cancer Res., 2001;61:6120-6130 (Pubitemid 32762548)
    • (2001) Cancer Research , vol.61 , Issue.16 , pp. 6120-6130
    • Bonnesen, C.1    Eggleston, I.M.2    Hayes, J.D.3
  • 10
  • 11
    • 57749182206 scopus 로고    scopus 로고
    • Synergistic effect of combination of phenethyl isothiocyanate and sulforaphane or curcumin and sulforaphane in the inhibition of inflammation
    • Cheung K. L., Khor T. O., Kong A. N.: Synergistic effect of combination of phenethyl isothiocyanate and sulforaphane or curcumin and sulforaphane in the inhibition of inflammation. Pharmaceut. Res., 2009;26:224-231
    • (2009) Pharmaceut. Res. , vol.26 , pp. 224-231
    • Cheung, K.L.1    Khor, T.O.2    Kong, A.N.3
  • 12
    • 0036511358 scopus 로고    scopus 로고
    • Sulforaphane and its metabolite mediate growth arrest and apoptosis in human prostate cancer cells
    • Chiao J. W., Chung F. L., Kancherla R., Ahmed T., Mittelman A., Conaway C. C.: Sulforaphane and its metabolite mediate growth arrest and apoptosis in human prostate cancer cells. Int. J. Oncol., 2002;20:631-636
    • (2002) Int. J. Oncol. , vol.20 , pp. 631-636
    • Chiao, J.W.1    Chung, F.L.2    Kancherla, R.3    Ahmed, T.4    Mittelman, A.5    Conaway, C.C.6
  • 13
    • 27644553527 scopus 로고    scopus 로고
    • 2/M arrest and caspase-mediated apoptosis induced by sulforaphane in DU145 prostate cancer cells
    • DOI 10.1207/s15327914nc5202-11
    • Cho S. D., Li G., Hu H., Jiang C, Kang K. S., Lee Y. S, Kim S. H., Lu J.: Involvement of c-jun N-terminal kinase in G2/M arrest and caspase-mediated apoptosis induced by sulforaphane in DU 145 prostate cancer cells. Nutr. Cancer, 2005;52:213-224 (Pubitemid 41579763)
    • (2005) Nutrition and Cancer , vol.52 , Issue.2 , pp. 213-224
    • Cho, S.-D.1    Li, G.2    Hu, H.3    Jiang, C.4    Kang, K.-S.5    Lee, Y.-S.6    Kim, S.-H.7    Lu, J.8
  • 14
    • 33845623882 scopus 로고    scopus 로고
    • D,L-Sulforaphane-induced cell death in human prostate cancer cells is regulated by inhibitor of apoptosis family proteins and Apaf-1
    • DOI 10.1093/carcin/bgl144
    • Choi S., Lew K. L., Xiao H., Herman-Antosiewicz A., Xiao D., Brown C. K., Singh S. V.: D, L-Sulforaphane-induced cell death in human prostate cancer cells is regulated by inhibitor of apoptosis family proteins and Apaf-1. Carcinogenesis, 2007;28:151-162 (Pubitemid 44942639)
    • (2007) Carcinogenesis , vol.28 , Issue.1 , pp. 151-162
    • Choi, S.1    Lew, K.L.2    Xiao, H.3    Herman-Antosiewicz, A.4    Xiao, D.5    Brown, C.K.6    Singh, S.V.7
  • 15
    • 2942527312 scopus 로고    scopus 로고
    • Role of Se-dependent glutathione peroxidases in gastrointestinal inflammation and cancer
    • DOI 10.1016/j.freeradbiomed.2004.04.010, PII S0891584904003132
    • Chu F. F., Esworthy R. S., Doroshow J. H.: Role of Se-dependent glutathione peroxidases in gastrointestinal inflammation and cancer. Free Radic. Biol. Med., 2004;36:1481-1495 (Pubitemid 38746557)
    • (2004) Free Radical Biology and Medicine , vol.36 , Issue.12 , pp. 1481-1495
    • Chu, F.-F.1    Esworthy, R.S.2    Doroshow, J.H.3
  • 16
    • 0034525122 scopus 로고    scopus 로고
    • Chemoprevention of colonic aberrant crypt foci in Fischer rats by sulforaphane and phenethyl isothiocyanate
    • Chung F. L., Conaway C. C., Rao C. V., Reddy B. S.: Chemoprevention of colonic aberrant crypt foci in Fisher rats by sulforaphane and phenethyl isothiocyanate. Carcinogenesis, 2000;21:2287-2291 (Pubitemid 32049237)
    • (2000) Carcinogenesis , vol.21 , Issue.12 , pp. 2287-2291
    • Chung, F.-L.1    Conaway, C.C.2    Rao, C.V.3    Reddy, B.S.4
  • 19
    • 0035813010 scopus 로고    scopus 로고
    • Role of MRP2 and GSH in intrahepatic cycling of toxins
    • DOI 10.1016/S0300-483X(01)00459-0, PII S0300483X01004590
    • Dietrich C. G., Ottenhoff R., de Waart D. R., OudeElferink R. P.: Role of MRP2 and GSH in intrahepatic cycling of toxins. Toxicology, 2001;167:73-81 (Pubitemid 32830948)
    • (2001) Toxicology , vol.167 , Issue.1 , pp. 73-81
    • Dietrich, C.G.1    Ottenhoff, R.2    De Waart, D.R.3    Oude Elferink, R.P.J.4
  • 22
    • 30844471529 scopus 로고    scopus 로고
    • Effect of sulforaphane on micronucleus induction in cultured human lymphocytes by four different mutagens
    • DOI 10.1002/em.20156
    • Fimognari C, Berti F., Cantelli-Forti G., Hrelia P.: Effect of sulforaphane on micronucleus induction in cultured human lymphocytes by four different mutagens. Environ. Mol. Mutagen., 2005;46:260-267 (Pubitemid 43107947)
    • (2005) Environmental and Molecular Mutagenesis , vol.46 , Issue.4 , pp. 260-267
    • Fimognari, C.1    Berti, F.2    Cantelli-Forti, G.3    Hrelia, P.4
  • 23
    • 45949107794 scopus 로고    scopus 로고
    • Induction of differentiation in human promyelocytic cells by the isothiocyanate sulforaphane
    • New Anticancer Agents
    • Fimognari C, Lenzi M., Cantelli-Forti G., Hrelia P.: Induction of differentiation in human promyelocytic cells by the isothiocyanate sulforaphane. In Vivo, 2008;22:317-320 (Pubitemid 351890808)
    • (2008) Vivo , vol.22 , Issue.3 , pp. 317-320
    • Fimognari, C.1    Lenzi, M.2    Cantelli-Forti, G.3    Hrelia, P.4
  • 24
    • 34047241356 scopus 로고    scopus 로고
    • Cell-cycle specificity of sulforaphane-mediated apoptosis in Jurkat T-leukemia cells
    • Fimognari C, Lenzi M., Sciuscio D., Cantelli-Forti G., Hrelia P.: Cell-cycle specificity of sulforaphane-mediated apoptosis in Jurkat T-leukemia cells. In Vivo, 2007;21:377-380 (Pubitemid 46534294)
    • (2007) Vivo , vol.21 , Issue.2 , pp. 377-380
    • Fimognari, C.1    Lenzi, M.2    Sciuscio, D.3    Cantelli-Forti, G.4    Hrelia, P.5
  • 25
    • 0036252496 scopus 로고    scopus 로고
    • Growth inhibition, cell-cycle arrest and apoptosis in human T-cell leukemia by the isothiocyanate sulforaphane
    • Fimognari C, Nusse M., Cesari R., Iori R., Cantelli-Forti G., Hrelia P.: Growth inhibition, cell-cycle arrest and apoptosis in human T-cell leukemia by the isothiocyanate sulforaphane, Carcinogenesis, 2002;23:581-586 (Pubitemid 34498494)
    • (2002) Carcinogenesis , vol.23 , Issue.4 , pp. 581-586
    • Fimognari, C.1    Nusse, M.2    Cesari, R.3    Iori, R.4    Cantelli-Forti, G.5    Hrelia, P.6
  • 27
    • 0034162822 scopus 로고    scopus 로고
    • Sulforaphane, a naturally occurring isothiocyanate, induces cell cycle arrest and apoptosis in HT29 human colon cancer cells
    • Gamet-Payrastre L., Li P., Lumeau S., Cassar G., Dupont M. A, Chevolleau S., Gasc N., Tulliez J., Terce F.: Sulforaphane, a naturally occurring isothiocyanate, induces cell cycle arrest and apoptosis in HT29 human colon cancer cells. Cancer Res., 2000;60:1426-1433 (Pubitemid 30152017)
    • (2000) Cancer Research , vol.60 , Issue.5 , pp. 1426-1433
    • Gamet-Payrastre, L.1    Li, P.2    Lumeau, S.3    Cassar, G.4    Dupont, M.-A.5    Chevolleau, S.6    Gasc, N.7    Tulliez, J.8    Terce, F.9
  • 28
    • 0031939472 scopus 로고    scopus 로고
    • Selective cytostatic and cytotoxic effects of glucosinolates hydrolysis products on human colon cancer cells in vitro
    • Gamet-Payrastre L., Lumeau S., Gasc N., Cassar G., Rollin P., Tulliez J.: Selective cytostatic and cytotoxic effects of glucosinolates hydrolysis products on human colon cancer cells in vitro. Anticancer Drugs, 1998;9:141-148 (Pubitemid 28080635)
    • (1998) Anti-Cancer Drugs , vol.9 , Issue.2 , pp. 141-148
    • Gamet-Payrastre, L.1    Lumeau, S.2    Gasc, N.3    Cassar, G.4    Rollin, P.5    Tulliez, J.6
  • 29
    • 0041847171 scopus 로고    scopus 로고
    • Cell cycle control and cancer
    • Garrett M. D.: Cell cycle control and cancer. Current Science, 2001;5:515-522 (Pubitemid 33616371)
    • (2001) Current Science , vol.81 , Issue.5 , pp. 515-522
    • Garrett, M.D.1
  • 31
    • 0345167177 scopus 로고    scopus 로고
    • Induction of medulloblastoma cell apoptosis by sulforaphane, a dietary anticarcinogen from Brassica vegetables
    • DOI 10.1016/j.canlet.2003.08.025
    • Gingras D., Gendron M., Boivin D., Moghrabi A., Theoret Y, Beliveau R.: Induction of medulloblastoma cell apoptosis by sulforaphane, a dietary anticarcinogen from Brassica vegetables. Cancer Lett., 2004;203:35-43 (Pubitemid 37506081)
    • (2004) Cancer Letters , vol.203 , Issue.1 , pp. 35-43
    • Gingras, D.1    Gendron, M.2    Boivin, D.3    Moghrabi, A.4    Theoret, Y.5    Beliveau, R.6
  • 33
    • 0031750787 scopus 로고    scopus 로고
    • Chemoprevention of cancer
    • DOI 10.1080/028418698429496
    • Hakama M.: Chemoprevention of cancer. Acta Oncol, 1998;37:227-230 (Pubitemid 28307844)
    • (1998) Acta Oncologica , vol.37 , Issue.3 , pp. 227-230
    • Hakama, M.1
  • 34
    • 0344011990 scopus 로고    scopus 로고
    • Efficacy of Sulforaphane in Eradicating Helicobacter pylori in Human Gastric Xenografts Implanted in Nude Mice
    • DOI 10.1128/AAC.47.12.3982-3984.2003
    • Haristoy X., Angioi-Duprez K., Duprez A., Lozniewski A.: Efficacy of sulforaphane in eradicating Helicobacter pylori in human gastric xenografts implanted in nude mice. Antimicrob. Agents Chemother., 2003;47:3982-3984 (Pubitemid 37485022)
    • (2003) Antimicrobial Agents and Chemotherapy , vol.47 , Issue.12 , pp. 3982-3984
    • Haristoy, X.1    Angioi-Duprez, K.2    Duprez, A.3    Lozniewski, A.4
  • 35
    • 0032980125 scopus 로고    scopus 로고
    • Chemoprevention of cancer by isothiocyanates, modifiers of carcinogen metabolism
    • Hecht S. S.: Chemoprevention of cancer by isothiocyanates, modifiers of carcinogen metabolism. J. Nutr., 1999;129:768S-774S
    • (1999) J. Nutr. , vol.129
    • Hecht, S.S.1
  • 36
    • 0035943597 scopus 로고    scopus 로고
    • Nuclear factor kappa B is a molecular target for sulforaphane-mediated antiinflammatory mechanisms
    • Heiss E, Herhaus C, Klimo K, Bartsch H, Gerhauser C: Nuclear factor kappa B is a molecular target for sulforaphane-mediated antiinflammatory mechanisms. J. Biol. Chem., 2001;276:32008-32015
    • (2001) J. Biol. Chem. , vol.276 , pp. 32008-32015
    • Heiss, E.1    Herhaus, C.2    Klimo, K.3    Bartsch, H.4    Gerhauser, C.5
  • 37
    • 34250757157 scopus 로고    scopus 로고
    • Induction of p21 protein protects against sulforaphane-induced mitotic arrest in LNCaP human prostate cancer cell line
    • DOI 10.1158/1535-7163.MCT-06-0807
    • Herman-Antosiewicz A., Xiao H., Lew K. L., Singh S. V: Induction of p21 protein protects against sulforaphane induced mitotic arrest in LnCaP human prostate cancer cell line. Mol. Cancer Ther., 2007;6:1673-1681 (Pubitemid 46954034)
    • (2007) Molecular Cancer Therapeutics , vol.6 , Issue.5 , pp. 1673-1681
    • Herman-Antosiewicz, A.1    Xiao, H.2    Lew, K.L.3    Singh, S.V.4
  • 39
    • 33749581701 scopus 로고    scopus 로고
    • Cancer chemoprevention of intestinal polyposis in ApcMin/+ mice by sulforaphane, a natural product derived from cruciferous vegetable
    • DOI 10.1093/carcin/bgl049
    • Hu R., Khor T. O., Shen G., Jeong W. S., Hebbar V, Chen C, Xu C, Reddy B., Chada K., Kong A. N: Cancer chemoprevention of intestinal polyposis in Apc min/+ mice by sulforaphane, a natural product derived from cruciferous vegetable. Carcinogenesis, 2006;27:2038-2046 (Pubitemid 44530579)
    • (2006) Carcinogenesis , vol.27 , Issue.10 , pp. 2038-2046
    • Hu, R.1    Khor, T.O.2    Shen, G.3    Jeong, W.-S.4    Hebbar, V.5    Chen, C.6    Xu, C.7    Reddy, B.8    Chada, K.9    Kong, A.-N.T.10
  • 40
    • 4444326097 scopus 로고    scopus 로고
    • Sulforaphane inhibits human MCF-7 mammary cancer cell mitotic progression and tubulin polymerization
    • Jackson S. J., Singletary K. W.: Sulforaphane inhibits human MCF-7 mammary cancer cell mitotic progression and tubulin polymerization. J. Nutr., 2004;134:2229-2236 (Pubitemid 39201590)
    • (2004) Journal of Nutrition , vol.134 , Issue.9 , pp. 2229-2236
    • Jackson, S.J.T.1    Singletary, K.W.2
  • 41
    • 1242307951 scopus 로고    scopus 로고
    • Sulforaphane: A naturally occuring mammary carcinoma mitotic inhibitor, which disrupts tubulin polymerization
    • DOI 10.1093/carcin/bgg192
    • Jackson S. J., Singletary K. W.: Sulforaphane: a naturally occurring mammary carcinoma mitotic inhibitor, which disrupts tubulin polymerization. Carcinogenesis, 2004;25:219-227 (Pubitemid 38239805)
    • (2004) Carcinogenesis , vol.25 , Issue.2 , pp. 219-227
    • Jackson, S.J.T.1    Singletary, K.W.2
  • 42
    • 23344431898 scopus 로고    scopus 로고
    • Isothiocyanates induce cell cycle arrest, apoptosis and mitochondrial potential depolarization in HL-60 and multidrug-resistant cell lines
    • Jakubikova J., Bao Y., Sedlak J.: Isothiocyanates induce cell cycle arrest, apoptosis and mitochondrial potential depolarization in HL-60 and multidrug-resistant cell lines. Anticancer Res., 2005;25:3375-3386 (Pubitemid 41105214)
    • (2005) Anticancer Research , vol.25 , Issue.5 , pp. 3375-3386
    • Jakubikova, J.1    Bao, Y.2    Sedlak, J.3
  • 43
    • 19344367171 scopus 로고    scopus 로고
    • 2/M arrest and cell death in Caco-2 cells
    • DOI 10.1016/j.bcp.2005.03.015, PII S0006295205001930
    • Jakubikova J., Sedlak J., Mithen R., Bao Y.: Role of PI3K/Akt and MEK/ERK signaling pathways in sulforaphane and erucin induced phase II enzymes and MRP2 transcription, G2/M arrest and cell death in Caco-2 cells. Biochem. Pharmacol., 2005;69:1543-1552 (Pubitemid 40719490)
    • (2005) Biochemical Pharmacology , vol.69 , Issue.11 , pp. 1543-1552
    • Jakubikova, J.1    Sedlak, J.2    Mithen, R.3    Bao, Y.4
  • 44
    • 76849112501 scopus 로고    scopus 로고
    • Combination treatment with resveratrol and sulforaphane Induces apoptosis in human U251 glioma cells
    • Jiang H., Shang X., Wu H., Huang G., Wang Y., Al-Holou S., Gautam S. C., Chopp M.: Combination treatment with resveratrol and sulforaphane Induces apoptosis in human U251 glioma cells. Neurochem. Res., 2010;35:152-161
    • (2010) Neurochem. Res. , vol.35 , pp. 152-161
    • Jiang, H.1    Shang, X.2    Wu, H.3    Huang, G.4    Wang, Y.5    Al-Holou, S.6    Gautam, S.C.7    Chopp, M.8
  • 45
    • 0037418625 scopus 로고    scopus 로고
    • Differential responses from seven mammalian cell lines to the treatments of detoxifying enzyme inducers
    • DOI 10.1016/S0024-3205(03)00101-2
    • Jiang Z. Q., Chen C, Yang B., Hebbar V, Kong A. N.: Differential responses from seven mammalian cell lines to the treatments of detoxifying enzyme inducers. Life Sci., 2003;72:2243-2253 (Pubitemid 36287361)
    • (2003) Life Sciences , vol.72 , Issue.20 , pp. 2243-2253
    • Jiang, Z.-Q.1    Chen, C.2    Yang, B.3    Hebbar, V.4    Kong, A.-N.T.5
  • 46
    • 33645468736 scopus 로고    scopus 로고
    • Modest induction of phase 2 enzyme activity in the F344 rat prostate
    • Jones S. B., Brooks J. D.: Modest induction of phase 2 enzyme activity in the F344 rat prostate. BMC Cancer, 2006;6:62-70
    • (2006) BMC Cancer , vol.6 , pp. 62-70
    • Jones, S.B.1    Brooks, J.D.2
  • 48
    • 33746422972 scopus 로고    scopus 로고
    • Activation of multiple molecular mechanisms for apoptosis in human malignant glioblastoma T98G and U87MG cells treated with sulforaphane
    • DOI 10.1016/j.neuroscience.2006.04.075, PII S0306452206006130
    • Karmakar S., Weinberg M. S., Banik N. L., Patel S. J., Ray S. K.: Activation of multiple molecular mechanisms for apoptosis in human malignant glioblastoma T98G and U87MG cells treated with sulforaphane. Neuroscience, 2006;141:1265-1280 (Pubitemid 44128679)
    • (2006) Neuroscience , vol.141 , Issue.3 , pp. 1265-1280
    • Karmakar, S.1    Weinberg, M.S.2    Banik, N.L.3    Patel, S.J.4    Ray, S.K.5
  • 49
    • 0030781225 scopus 로고    scopus 로고
    • Biotransformation of the naturally occurring isothiocyanate sulforaphane in the rat: Identification of phase I metabolites and glutathione conjugates
    • DOI 10.1021/tx970080t
    • Kassahun M., Davis M., Hu P., Martin B., Baillie T: Biotransformation of the naturally occurring isothiocyanate sulforaphane in the rat: identification of phase I metabolites and glutathione conjugates. Chem. Res. Toxicol., 1997;10:1228-1233 (Pubitemid 27524827)
    • (1997) Chemical Research in Toxicology , vol.10 , Issue.11 , pp. 1228-1233
    • Kassahun, K.1    Davis, M.2    Hu, P.3    Martin, B.4    Baillie, T.5
  • 50
    • 0036319611 scopus 로고    scopus 로고
    • Chemoprotective effects of garden cress (Lepidium sativum) and its constituents towards 2-amino-3-methyl-imidazo[4,5-f]quinoline (IQ)-induced genotoxic effects and colonic preneoplastic lesions
    • Kassie F., Rabot S., Uhl M., Huber W., Qin H. M., Helma C, Schulte-Hermann R., Knasmuller S.: Chemoprotective of garden cress (Lepidium sativum) and its constituents towards 2-amino-3-methyl-imidazo[4, - 5-f]quinoline (IQ)-induced genotoxic effects and colonic preneoplastic lesions. Carcinogenesis, 2002;23:1155-1161 (Pubitemid 34814773)
    • (2002) Carcinogenesis , vol.23 , Issue.7 , pp. 1155-1161
    • Kassie, F.1    Rabot, S.2    Uhl, M.3    Huber, W.4    Qin, H.M.5    Helma, C.6    Schulte-Hermann, R.7    Knasmuller, S.8
  • 51
    • 0037330680 scopus 로고    scopus 로고
    • Chemoprevention of 2-amino-3-methylimidazo[4,5-f]quinoline (IQ)-induced colonic and hepatic preneoplastic lesions in the F344 rat by cruciferous vegetables administered simultaneously with the carcinogen
    • DOI 10.1093/carcin/24.2.255
    • Kassie F., Uhl M., Rabot S., Grasl-Kraupp B., Verkerk R., Kundi M., Chabicovsky M., Schulte-Hermann R., Knasmuller S.: Chemoprevention of 2-amino-3-methyl-imidazo[4, 5-f]quinoline (IQ)-induced colonic and hepatic preneoplastic lesions in F344 rat by cruciferous vegetables administered simultanously with the carcinogen. Carcinogenesis, 2003;24:255-261 (Pubitemid 36267094)
    • (2003) Carcinogenesis , vol.24 , Issue.2 , pp. 255-261
    • Kassie, F.1    Uhl, M.2    Rabot, S.3    Grasl-Kraupp, B.4    Verkerk, R.5    Kundi, M.6    Chabicovsky, M.7    Schulte-Hermann, R.8    Knasmuller, S.9
  • 52
    • 0037947696 scopus 로고    scopus 로고
    • Food matrix effects on bioactivity of broccoli-derived sulforaphane in liver and colon of F344 rats
    • Keck A. S., Qiao Q., Jeffery E. H.: Food matrix effects on bioactivity of broccoli-derived sulforaphane in liver and colon of F344 rats. J. Agric. Food Chem., 2003;51:3320-3327
    • (2003) J. Agric. Food Chem. , vol.51 , pp. 3320-3327
    • Keck, A.S.1    Qiao, Q.2    Jeffery, E.H.3
  • 53
    • 33644777732 scopus 로고    scopus 로고
    • The phase 2 enzyme inducers ethacrynic acid, DL-sulforaphane, and oltipraz inhibit lipopolysaccharide-induced high-mobility group box 1 secretion by RAW 264.7 cells
    • DOI 10.1124/jpet.105.092841
    • Killeen M. E., Englert J. A., Stolz D. B., Song M., Han Y., Delude R. L., Kellum J. A., Fink M. P.: The phase 2 enzyme inducers ethacrynic acid, DL-sulforaphane, and oltipraz inhibit lipopolysaccharide-induced high-mobility group box 1 secretion by RAW 264.7 cells. J. Pharmacol. Exp. Ther., 2006;316:1070-1079 (Pubitemid 43345280)
    • (2006) Journal of Pharmacology and Experimental Therapeutics , vol.316 , Issue.3 , pp. 1070-1079
    • Killeen, M.E.1    Englert, J.A.2    Stolz, D.B.3    Song, M.4    Han, Y.5    Delude, R.L.6    Kellum, J.A.7    Fink, M.P.8
  • 54
    • 32944475745 scopus 로고    scopus 로고
    • Sulforaphane sensitizes tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-resistant hepatoma cells to TRAIL-induced apoptosis through reactive oxygen species-mediated up-regulation of DR5
    • DOI 10.1158/0008-5472.CAN-05-1568
    • Kim E., Kim E. H., Eom Y. W., Kim W. H., Kwon K. W., Lee S. J., Choi K. S.: Sulforaphane sensitizes tumor necrosis factor related apoptosisinducing ligand (TRAIL)-resistant hepatoma cells to TRAIL-induced apoptosis through reactive oxygen species-mediated up-regulation of DR5. Cancer Res., 2006;66:1740-1750 (Pubitemid 43259959)
    • (2006) Cancer Research , vol.66 , Issue.3 , pp. 1740-1750
    • Kim, H.1    Kim, E.H.2    Eom, Y.W.3    Kim, W.-H.4    Kwon, T.K.5    Lee, S.J.6    Choi, K.S.7
  • 55
    • 33746701934 scopus 로고    scopus 로고
    • Protective effects of benzyl isothiocyanate and sulforaphane but not resveratrol against initiation of pancreatic carcinogenesis in hamsters
    • DOI 10.1016/j.canlet.2005.10.028, PII S0304383505009456
    • Kuroiwa Y., Nishikawa A., Kitamura Y., Kanki K., Ishii Y., Umemura T., Hirose M.: Protective effects of benzyl isothiocyanate and sulforaphane but not resveratrol against initiation of pancreatic carcinogenesis in hamsters. Cancer Lett., 2006;241:275-280 (Pubitemid 44163037)
    • (2006) Cancer Letters , vol.241 , Issue.2 , pp. 275-280
    • Kuroiwa, Y.1    Nishikawa, A.2    Kitamura, Y.3    Kanki, K.4    Ishii, Y.5    Umemura, T.6    Hirose, M.7
  • 57
    • 0036792160 scopus 로고    scopus 로고
    • Brassica, biotransformation and cancer risk: Genetic polymorphisms alter the preventive effects of cruciferous vegetables
    • Lampe J. W., Peterson S.: Brassica, biotransformation and cancer risk: genetic polymorphisms alter the preventive effects of cruciferous vegetables. J. Nutr., 2002;132:2991-2994
    • (2002) J. Nutr. , vol.132 , pp. 2991-2994
    • Lampe, J.W.1    Peterson, S.2
  • 58
    • 33646496792 scopus 로고    scopus 로고
    • Determination of sulforaphane in broccoli and cabbage by high-performance liquid chromatography
    • Liang H., Yuan Q. P., Dong H. R., Liu Y. M.: Determination of sulforaphane in broccoli and cabbage by high-performance liquid chromatography. J. Food Comp. Anal., 2006;19:473-476
    • (2006) J. Food Comp. Anal. , vol.19 , pp. 473-476
    • Liang, H.1    Yuan, Q.P.2    Dong, H.R.3    Liu, Y.M.4
  • 60
    • 52949139019 scopus 로고    scopus 로고
    • Sulforaphane suppressed LPS-induced inflammation in mouse peritoneal macrophages through Nrf2 dependent pathway
    • Lin W., Wu R. T., Wu T., Khor T. O., Wang H., Kong A. N.: Sulforaphane suppressed LPS-induced inflammation in mouse peritoneal macrophages through Nrf2 dependent pathway. Biochem. Pharmacol, 2008;76:967-973
    • (2008) Biochem. Pharmacol. , vol.76 , pp. 967-973
    • Lin, W.1    Wu, R.T.2    Wu, T.3    Khor, T.O.4    Wang, H.5    Kong, A.N.6
  • 61
    • 0034718294 scopus 로고    scopus 로고
    • Isothiocyanates, glutathione S-transferase M1 and T1 polymorphisms, and lung-cancer risk: A prospective study of men in Shanghai, China
    • London S. J., Yuan J. M., Chung F. L., Gao Y. T., Coetzee G. A., Ross R. K., Yu M. C.: Isothiocyanates, glutathione S-transferase M1 and T1 polymorphisms, and lung-cancer risk: a prospective study of men in Shanghai, China. Lancet, 2000;356:724-729 (Pubitemid 30663242)
    • (2000) Lancet , vol.356 , Issue.9231 , pp. 724-729
    • London, S.J.1    Yuan, J.-M.2    Chung, F.-L.3    Gao, Y.-T.4    Coetzee, G.A.5    Ross, R.K.6    Yu, M.C.7
  • 62
    • 0030852501 scopus 로고    scopus 로고
    • Inhibition of cytochromes P-450 and induction of glutathione S- transferases by sulforaphane in primary human and rat hepatocytes
    • Maheo K., Morel F., Langouet S., Kramer H., Le Ferrec E., Ketterer B., Guillouzo A.: Inhibition of cytochromes P-450 and induction of glutathione S-transferases by sulforaphane in primary human and rat hepatocytes. Cancer Res., 1997;57:3649-3652 (Pubitemid 27381200)
    • (1997) Cancer Research , vol.57 , Issue.17 , pp. 3649-3652
    • Maheo, K.1    Morel, F.2    Langouet, S.3    Kramer, H.4    Le Ferrec, E.5    Ketterer, B.6    Guillouzo, A.7
  • 63
    • 9744283511 scopus 로고    scopus 로고
    • Transcription factor nrf2 is essential for induction of NAD (P) H: Quinone oxidoreductase 1, glutathione S-transferases, and glutamate cysteine ligase by broccoli seeds and isothiocyanates
    • McWalter G. K., Higgins L. G., McLellan L. I., Henderson C. J., Song L., Thornalley P. J., Itoh K., Yamamoto M., Hayes J. D.: Transcription factor nrf2 is essential for induction of NAD (P) H:quinone oxidoreductase 1, glutathione S-transferases, and glutamate cysteine ligase by broccoli seeds and isothiocyanates. J. Nutr., 2004;134:3499-3506
    • (2004) J. Nutr. , vol.134 , pp. 3499-3506
    • McWalter, G.K.1    Higgins, L.G.2    McLellan, L.I.3    Henderson, C.J.4    Song, L.5    Thornalley, P.J.6    Itoh, K.7    Yamamoto, M.8    Hayes, J.D.9
  • 64
    • 0038025250 scopus 로고    scopus 로고
    • Development of isothiocyanate-enriched broccoli, and its enhanced ability to induce phase 2 detoxification enzymes in mammalian cells
    • Mithen R., Faulkner K., Magrath R, Rose P., Williamson G., Marquez J.: Development of isothiocyanate-enriched broccoli, and its enhanced ability to induce phase 2 detoxification enzymes in mammalian cells. Theor. Appl. Genet., 2003;106:727-734 (Pubitemid 36599842)
    • (2003) Theoretical and Applied Genetics , vol.106 , Issue.4 , pp. 727-734
    • Mithen, R.1    Faulkner, K.2    Magrath, R.3    Rose, P.4    Williamson, G.5    Marquez, J.6
  • 65
    • 33644646401 scopus 로고    scopus 로고
    • Chemoprotection by sulforaphane: Keep one eye beyond Keap1
    • DOI 10.1016/j.canlet.2005.02.033, PII S030438350500203X
    • Myzak M. C., Dashwood R. H.: Chemoprotection by sulforaphane: Keep one eye beyond Keap1. Cancer Lett., 2006;233:208-218 (Pubitemid 43327375)
    • (2006) Cancer Letters , vol.233 , Issue.2 , pp. 208-218
    • Myzak, M.C.1    Dashwood, R.H.2
  • 66
    • 33645825587 scopus 로고    scopus 로고
    • min mice
    • DOI 10.1096/fj.05-4785fje
    • Myzak M. C., Dashwood W. M., Orner G. A., Ho E., Dashwood R. H.: Sulforaphane inhibits histone deacetylase in vivo and suppresses tumorigenesis in Apc-minus mice. FASEB J., 2006;20:506-508 (Pubitemid 46671231)
    • (2006) FASEB Journal , vol.20 , Issue.3 , pp. 506-508
    • Myzak, M.C.1    Dashwood, W.M.2    Orner, G.A.3    Ho, E.4    Dashwood, R.H.5
  • 67
    • 33645324413 scopus 로고    scopus 로고
    • Sulforaphane inhibits histone deacetylase activity in BPH-1, LnCaP and PC-3 prostate epithelial cells
    • Myzak M. C., Hardin K., Wang R., Dashwood R. H., Ho E.: Sulforaphane inhibits histone deacetylase activity in BPH-1, LnCaP and PC-3 prostate epithelial cells. Carcinogenesis, 2006;27:811-819
    • (2006) Carcinogenesis , vol.27 , pp. 811-819
    • Myzak, M.C.1    Hardin, K.2    Wang, R.3    Dashwood, R.H.4    Ho, E.5
  • 68
    • 4143130097 scopus 로고    scopus 로고
    • A novel mechanism of chemoprotection by sulforaphane: Inhibition of histone deacetylase
    • DOI 10.1158/0008-5472.CAN-04-1326
    • Myzak M. C., Karplus P. A., Chung, F. L., Dashwood R. H.: A novel mechanism of chemoprotection by sulforaphane: inhibition of histone deacetylase. Cancer Res., 2004;64:5767-5774 (Pubitemid 39095576)
    • (2004) Cancer Research , vol.64 , Issue.16 , pp. 5767-5774
    • Myzak, M.C.1    Karplus, P.A.2    Chung, F.-L.3    Dashwood, R.H.4
  • 69
    • 33846838750 scopus 로고    scopus 로고
    • Sulforaphane retards the growth of human PC-3 xenografts and inhibits HDAC activity in human subjects
    • Myzak M. C., Tong P., Dashwood W. M., Dashwood R. H., Ho E.: Sulforaphane retards the growth of human PC-3 xenografts and inhibits HDAC activity in human subjects. Exp. Biol. Med. (Maywood), 2007;232:227-234 (Pubitemid 46203291)
    • (2007) Experimental Biology and Medicine , vol.232 , Issue.2 , pp. 227-234
    • Myzak, M.C.1    Tong, P.2    Dashwood, W.-M.3    Dashwood, R.H.4    Ho, E.5
  • 70
    • 34548106014 scopus 로고    scopus 로고
    • Biphasic modulation of cell proliferation by sulforaphane at physiologically relevant exposure times in a human colon cancer cell line
    • DOI 10.1002/mnfr.200700115
    • Pappa G., Bartsch H., Gerhauser C: Biphasic modulation of cell proliferation by sulforaphane at physiologically relevant exposure times in a human colon cancer cell line. Mol. Nutr. Food Res., 2007;51:977-984 (Pubitemid 47292272)
    • (2007) Molecular Nutrition and Food Research , vol.51 , Issue.8 , pp. 977-984
    • Pappa, G.1    Bartsch, H.2    Gerhauser, C.3
  • 71
    • 33745875948 scopus 로고    scopus 로고
    • Comparison of growth inhibition profiles and mechanisms of apoptosis induction in human colon cancer cell lines by isothiocyanates and indoles from Brassicaceae
    • DOI 10.1016/j.mrfmmm.2006.01.007, PII S0027510706000492
    • Pappa G., Lichtenberg M., Iori R., Barillari J., Bartsch H., Gerhauser C: Comparison of growth inhibition profiles and mechanisms of apoptosis induction in human colon cancer cell lines by isothiocyanates and indoles from Brassicaceae. Mutation Res., 2006;599:76-87 (Pubitemid 44041504)
    • (2006) Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis , vol.599 , Issue.1-2 , pp. 76-87
    • Pappa, G.1    Lichtenberg, M.2    Iori, R.3    Barillari, J.4    Bartsch, H.5    Gerhauser, C.6
  • 72
    • 34548028505 scopus 로고    scopus 로고
    • Induction of apoptosis by isothiocyanate sulforaphane in human cervical carcinoma HeLa and hepatocarcinoma HepG2 cells through activation of caspase-3
    • Park S. Y., Kim G. Y., Bae S. J., Yoo Y. H., Choi Y. H.: Induction of apoptosis by isothiocyanate sulforaphane in human cervical carcinoma HeLa and hepatocarcinoma HepG2 cells through activation of caspase-3. Oncol. Rep., 2007;18:181-187
    • (2007) Oncol. Rep. , vol.18 , pp. 181-187
    • Park, S.Y.1    Kim, G.Y.2    Bae, S.J.3    Yoo, Y.H.4    Choi, Y.H.5
  • 75
    • 7444229836 scopus 로고    scopus 로고
    • The dietary isothiocyanate sulforaphane targets pathways of apoptosis, cell cycle arrest, and oxidative stress in human pancreatic cancer cells and inhibits tumor growth in severe combined immunodeficient mice
    • Pham N. A., Jacobberger J. W., Schimmer A. D., Cao P., Gronda M., Hedley D. W.: The dietary isothiocyanate sulforaphane targets pathways of apoptosis, cell cycle arrest, and oxidative stress in human pancreatic cancer cells and inhibits tumor growth in severe combined immunodefcient mice. Mol. Cancer Ther., 2004;3:1239-1248 (Pubitemid 39440169)
    • (2004) Molecular Cancer Therapeutics , vol.3 , Issue.10 , pp. 1239-1248
    • Pham, N.-A.1    Jacobberger, J.W.2    Schimmer, A.D.3    Cao, P.4    Gronda, M.5    Hedley, D.W.6
  • 76
    • 27744435860 scopus 로고    scopus 로고
    • Broccoli and watercress suppress matrix metalloproteinase-9 activity and invasiveness of human MDA-MB-231 breast cancer cells
    • DOI 10.1016/j.taap.2005.04.010, PII S0041008X05001675
    • Rose P., Huang Q., Ong C. N., Whiteman M.: Broccoli and watercress suppress matrix metalloproteinase-9 activity and invasiveness of human MDA-MB-231 breast cancer cells. Toxicol. Appl. Pharmacol., 2005;209:105-113 (Pubitemid 41587401)
    • (2005) Toxicology and Applied Pharmacology , vol.209 , Issue.2 , pp. 105-113
    • Rose, P.1    Huang, Q.2    Ong, C.N.3    Whiteman, M.4
  • 77
    • 67949110954 scopus 로고    scopus 로고
    • Activation of several concurrent proapoptic pathways by sulforaphane in human colon cancer cells SW620
    • Rudolf E., Andelova H., Cervinka M.: Activation of several concurrent proapoptic pathways by sulforaphane in human colon cancer cells SW620. Food Chem. Toxicol., 2009;47:2366-2373
    • (2009) Food Chem. Toxicol. , vol.47 , pp. 2366-2373
    • Rudolf, E.1    Andelova, H.2    Cervinka, M.3
  • 78
    • 21744457108 scopus 로고    scopus 로고
    • Global histone modification patterns predict risk of prostate cancer recurrence
    • DOI 10.1038/nature03672
    • Seligson D. B., Horvath S., Shi T., Yu H., Tze S., Grunstein M., Kurdistani S. K.: Global histone modification patterns predict risk of prostate cancer recurrence. Nature, 2005;435:1262-1266 (Pubitemid 40943093)
    • (2005) Nature , vol.435 , Issue.7046 , pp. 1262-1266
    • Seligson, D.B.1    Horvath, S.2    Shi, T.3    Yu, H.4    Tze, S.5    Grunstein, M.6    Kurdistani, S.K.7
  • 79
    • 0031711928 scopus 로고    scopus 로고
    • Urinary total isothiocyanate (ITC) in a population-based sample of middle-aged and older Chinese in Singapore: Relationship with dietary total ITC and glutathione S-transferase M1/T1/P1 genotypes
    • Seow A., Shi C. Y., Chung F. L., Jiao D., Hankin J. H, Lee H. P, Coetzee G. A., Yu M. C.: Urinary total isothiocyanate (ITC) in a population-based sample of middle-aged and older Chinese in Singapore: relationship with dietary total ITC and glutathione S-transferase M1/T1/P1 genotypes. Cancer Epidemiol. Biomarkers Prev., 1998;7:775-781 (Pubitemid 28420615)
    • (1998) Cancer Epidemiology Biomarkers and Prevention , vol.7 , Issue.9 , pp. 775-781
    • Seow, A.1    Shi, C.-Y.2    Chung, F.-L.3    Jiao, D.4    Hankin, J.H.5    Lee, H.-P.6    Coetzee, G.A.7    Yu, M.C.8
  • 80
    • 28244459182 scopus 로고    scopus 로고
    • Effect of glutathione-S-transferase polymorphisms on the cancer preventive potential of isothiocyanates: An epidemiological perspective
    • DOI 10.1016/j.mrfmmm.2005.06.004, PII S002751070500240X
    • Seow A., Vainio H., Yu M. C.: Effect of glutathione-stransferase polymorphisms on the cancer preventive potential of isothiocyanates: an epidemiological perspective. Mutat. Res., 2005;592:58-67 (Pubitemid 41714044)
    • (2005) Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis , vol.592 , Issue.1-2 , pp. 58-67
    • Seow, A.1    Vainio, H.2    Yu, M.C.3
  • 81
    • 0036949607 scopus 로고    scopus 로고
    • Dietary isothiocyanates, glutathione S-transferase polymorphisms and colorectal cancer risk in the Singapore Chinese Health Study
    • DOI 10.1093/carcin/23.12.2055
    • Seow A., Yuan J. M., Sun C. L., Van Den Berg D., Lee H. P, Yu M. C: Dietary isothiocyanates, glutathione S-transferase polymorphisms and colorectal cancer risk in the Singapore Chinese Health Study. Carcinogenesis, 2002;23:2055-2061 (Pubitemid 36104958)
    • (2002) Carcinogenesis , vol.23 , Issue.12 , pp. 2055-2061
    • Seow, A.1    Yuan, J.-M.2    Sun, C.-L.3    Van Den Berg, D.4    Lee, H.-P.5    Yu, M.C.6
  • 82
    • 0032406798 scopus 로고    scopus 로고
    • Human metabolism and excretion of cancer chemoprotective glucosinolates and isothiocyanates of cruciferous vegetables
    • Shapiro T. A., Fahey J. W., Wade K. L., Stephenson K. K., Talalay P.: Human metabolism and excretion of cancer chemoprotective glucosinolates and isothiocyanates of cruciferous vegetables. Cancer Epidemiol. Biomarkers Prev., 1998;7:1091-1100 (Pubitemid 29001665)
    • (1998) Cancer Epidemiology Biomarkers and Prevention , vol.7 , Issue.12 , pp. 1091-1100
    • Shapiro, T.A.1    Fahey, J.W.2    Wade, K.L.3    Stephenson, K.K.4    Talalay, P.5
  • 83
    • 33644841610 scopus 로고    scopus 로고
    • p53-independent G1 cell cycle arrest of human colon carcinoma cells HT-29 by sulforaphane is associated with induction of p21CIP1 and inhibition of expression of cyclin D1
    • Shen G., Xu C, Chen C, Hebbar V, Kong A. N.: p53-independent G1 cell cycle arrest of human colon carcinoma cells HT-29 by sulforaphane is associated with induction of p21CIP1 and inhibition of expression of cyclin D1. Cancer Chemother. Pharmacol., 2006;57:317-327
    • (2006) Cancer Chemother. Pharmacol. , vol.57 , pp. 317-327
    • Shen, G.1    Xu, C.2    Chen, C.3    Hebbar, V.4    Kong, A.N.5
  • 84
    • 1642545614 scopus 로고    scopus 로고
    • Sulforaphane induces caspase-mediated apoptosis in cultured PC-3 human prostate cancer cells and retards growth PC-3 xenografts in vivo
    • DOI 10.1093/carcin/bgg178
    • Singh A. V, Xiao D., Lew K. L., Dhir R., Singh S. V: Sulforaphane induces caspase-mediated apoptosis in cultured PC-3 human prostate cancer cells and retards growth of PC-3 xenografts in vivo. Carcinogenesis, 2004;25:83-90 (Pubitemid 38128621)
    • (2004) Carcinogenesis , vol.25 , Issue.1 , pp. 83-90
    • Singh, A.V.1    Xiao, D.2    Lew, K.L.3    Dhir, R.4    Singh, S.V.5
  • 87
    • 0034601232 scopus 로고    scopus 로고
    • Inhibition of benzo[a]pyrene- and 1,6-dinitropyrene-DNA adduct formation in human mammary epithelial cells bydibenzoylmethane and sulforaphane
    • DOI 10.1016/S0304-3835(00)00412-2, PII S0304383500004122
    • Singletary K., MacDonald C: Inhibition of benzo[a]pyrene and 1, 6-dinitropyrene-DNA adduct formation in human mammary epithelial cells by dibenzoylmethane and sulforaphane. Cancer Lett., 2000;155:47-54 (Pubitemid 30256223)
    • (2000) Cancer Letters , vol.155 , Issue.1 , pp. 47-54
    • Singletary, K.1    MacDonald, C.2
  • 89
    • 4544247421 scopus 로고    scopus 로고
    • Interactions between sulforaphane and apigenin in the induction of UGT1A1 and GSTA1 in CaCo-2 cells
    • DOI 10.1093/carcin/bgh169
    • Svehlikova V, Wang S., Jakubikova J., Williamson G., Mithen R., Bao Y.: Interactions between sulforaphane and apigenin in the induction of UGT1A1 and GSTA1 in Caco-2 cells. Carcinogenesis, 2004;25:1629-1637 (Pubitemid 39214305)
    • (2004) Carcinogenesis , vol.25 , Issue.9 , pp. 1629-1637
    • Svehlikova, V.1    Wang, S.2    Jakubikova, J.3    Williamson, G.4    Mithen, R.5    Bao, Y.6
  • 90
    • 33646201718 scopus 로고    scopus 로고
    • Antimetastatic activity of sulforaphane
    • Thejass P., Kuttan G.: Antimetastatic activity of sulforaphane. Life Sci., 2006;78:3043-3050
    • (2006) Life Sci. , vol.78 , pp. 3043-3050
    • Thejass, P.1    Kuttan, G.2
  • 91
    • 0037106099 scopus 로고    scopus 로고
    • Identification of Nrf2-regulated genes induced by the chemopreventive agent sulforaphane by oligonucleotide microarray
    • Thimmulappa R. K., Mai K. H., Srisuma S., Kensler T. W., Yamamoto M., Biswal S.: Identification of Nrf2-regulated genes induced by the chemopreventive agent sulforaphane by oligonucleotide microarray. Cancer Res., 2005;62:5196-5203
    • (2005) Cancer Res. , vol.62 , pp. 5196-5203
    • Thimmulappa, R.K.1    Mai, K.H.2    Srisuma, S.3    Kensler, T.W.4    Yamamoto, M.5    Biswal, S.6
  • 92
    • 3843072178 scopus 로고    scopus 로고
    • Targeting cell cycle machinery as a molecular mechanism of sulforaphane in prostate cancer prevention
    • Wang L., Liu D., Ahmed T., Chung F. L., Conaway C, Chiao J. W.: Targeting cell cycle machinery as a molecular mechanism of sulforaphane in prostate cancer prevention. Int. J. Oncol., 2004;24:187-192
    • (2004) Int. J. Oncol. , vol.24 , pp. 187-192
    • Wang, L.1    Liu, D.2    Ahmed, T.3    Chung, F.L.4    Conaway, C.5    Chiao, J.W.6
  • 93
    • 17844392872 scopus 로고    scopus 로고
    • Dietary intake of Cruciferous vegetables, Glutathione S-transferase (GST) polymorphisms and lung cancer risk in a Caucasian population
    • DOI 10.1007/s10552-004-1093-1
    • Wang L. I., Giovannucci E. L., Hunter D., Neuberg D., Su L., Christiani D. C: Dietary intake of cruciferous vegetables, glutathione S-transferase (GST) polymorphisms and lung cancer risk in Caucasian population. Cancer Causes Control, 2004;15:977-985 (Pubitemid 41449278)
    • (2004) Cancer Causes and Control , vol.15 , Issue.10 , pp. 977-985
    • Wang, L.I.1    Giovannucci, E.L.2    Hunter, D.3    Neuberg, D.4    Su, L.5    Christiani, D.C.6
  • 94
    • 33846120227 scopus 로고    scopus 로고
    • Mechanizmy przerzutowania i molekularne markery progresji nowotworów złośliwych. I. Rak jelita grubego
    • Wideł M. S., Wideł M.: Mechanizmy przerzutowania i molekularne markery progresji nowotworów złośliwych. I. Rak jelita grubego. Postȩpy Hig. Med. Dosw., 2006;60:453-470
    • (2006) Postȩpy Hig. Med. Dosw. , vol.60 , pp. 453-470
    • Wideł, M.S.1    Wideł, M.2
  • 95
    • 0032480901 scopus 로고    scopus 로고
    • Correlation of human jejunal permeability (in vivo) of drugs with experimentally and theoretically derived parameters. A multivariate data analysis approach
    • DOI 10.1021/jm9810102
    • Winiwarter S., Bonham N. M., Ax F., Hallberg A., Lennernas H., Karlen A.: Correlation of human jejunal permeability (in vivo) of drugs with experimentally and theoretically derived parameters. A multivariate data analysis approach. J. Med. Chem., 1998;41:4939-4949 (Pubitemid 28555452)
    • (1998) Journal of Medicinal Chemistry , vol.41 , Issue.25 , pp. 4939-4949
    • Winiwarter, S.1    Bonham, N.M.2    Ax, F.3    Hallberg, A.4    Lennernas, H.5    Karlen, A.6
  • 96
    • 0025847582 scopus 로고
    • Matrix metalloproteinases and their inhibitors in connective tissue remodeling
    • Woessner J. F. Jr: Matrix metalloproteinases and their inhibitors in connective tissue remodeling. FASEB J., 1991;5:2145-2154 (Pubitemid 21905847)
    • (1991) FASEB Journal , vol.5 , Issue.8 , pp. 2145-2154
    • Woessner Jr., J.F.1
  • 97
    • 33644865443 scopus 로고    scopus 로고
    • ERK and JNK signaling pathways are involved in the regulation of activator protein 1 and cell death elicited by three isothiocyanates in human prostate cancer PC-3 cells
    • DOI 10.1093/carcin/bgi251
    • Xu C, Shen G., Yuan X., Kim J. H., Gopalkrishnan A., Keum Y. S.: ERK and JNK signaling pathways are involved in the regulation of activator protein 1 and cell death elicited by three isothiocyanates in human prostate cancer PC-3 cells. Carcinogenesis, 2006;27:437-445 (Pubitemid 43372873)
    • (2006) Carcinogenesis , vol.27 , Issue.3 , pp. 437-445
    • Xu, C.1    Shen, G.2    Yuan, X.3    Kim, J.-H.4    Gopalkrishnan, A.5    Keum, Y.-S.6    Nair, S.7    Kong, A.-N.T.8
  • 98
    • 0028324459 scopus 로고
    • Cytochrome P-450 enzymes as targets for chemoprevention against chemical carcinogenesis and toxicity: Opportunities and limitations
    • Yang C. S., Smith T. J., Hong J. Y.: Cytochrome P-450 enzymes as targets for chemoprevention against chemical carcinogenesis and toxicity: opportunities and limitations. Cancer Res., 1994;54:1982s-1986s (Pubitemid 24132160)
    • (1994) Cancer Research , vol.54 , Issue.7 SUPPL.
    • Yang, C.S.1    Smith, T.J.2    Hong, J.-Y.3
  • 99
    • 0036135910 scopus 로고    scopus 로고
    • Quantitative determination of dithiocarbamates in human plasma, serum, erythrocytes and urine: Pharmacokinetics of broccoli sprout isothiocyanates in humans
    • DOI 10.1016/S0009-8981(01)00727-6, PII S0009898101007276
    • Ye L., Dinkova-Kostova A. T., Wade K. L., Zhang Y., Shapiro T. A., Talalay P.: Quantitative determination of dithiocarbamates in human plasma, serum, erythrocytes and urine: pharmacokinetics of broccoli sprout isothiocyanates in humans. Clin. Chim. Acta, 2002;316:43-53 (Pubitemid 34028187)
    • (2002) Clinica Chimica Acta , vol.316 , Issue.1-2 , pp. 43-53
    • Ye, L.1    Dinkova-Kostova, A.T.2    Wade, K.L.3    Zhang, Y.4    Shapiro, T.A.5    Talalay, P.6
  • 100
    • 27944494853 scopus 로고    scopus 로고
    • Effect of sulforaphane on metallothionein expression and induction of apoptosis in human hepatoma HepG2 cells
    • Yeh C. T., Yen G. C.: Effect of sulforaphane on metallothionein expression and induction of apoptosis in human hepatoma HepG2 cells. Carcinogenesis, 2005;26:2138-2148
    • (2005) Carcinogenesis , vol.26 , pp. 2138-2148
    • Yeh, C.T.1    Yen, G.C.2
  • 101
    • 5144230473 scopus 로고    scopus 로고
    • Cancer-preventive isothiocyanates: Measurement of human exposure and mechanism of action
    • DOI 10.1016/j.mrfmmm.2004.04.017, PII S0027510704002908
    • Zhang Y.: Cancer-preventive isothiocyanates: measurement of human exposure and mechanism of action. Mutation Res., 2004;555:173-190 (Pubitemid 39345403)
    • (2004) Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis , vol.555 , Issue.1-2 SPEC. ISS. , pp. 173-190
    • Zhang, Y.1
  • 102
    • 0037093463 scopus 로고    scopus 로고
    • High cellular accumulation of sulphoraphane, a dietary anticarcinogen, is followed by rapid transporter-mediated export as a glutathione conjugate
    • Zhang Y, Callaway E. C.: High cellular accumulation of sulphoraphane, a dietary anticarcinogen, is followed by rapid transporter-mediated export as a glutathione conjugate. Biochem. J., 2002;364:301-307 (Pubitemid 34538974)
    • (2002) Biochemical Journal , vol.364 , Issue.1 , pp. 301-307
    • Zhang, Y.1    Callaway, E.C.2
  • 103
    • 0026577605 scopus 로고
    • A major inducer of anticarcinogenic protective enzymes from broccoli: Isolation and elucidation of structure
    • Zhang Y., Talalay P., Cho G. C., Posner G. H.: A major inducer of anticarcinogenic protective enzymes from broccoli: isolation and elucidation of structure. Proc. Natl. Acad. Sci. USA, 1992;89:2399-2403
    • (1992) Proc. Natl. Acad. Sci. USA , vol.89 , pp. 2399-2403
    • Zhang, Y.1    Talalay, P.2    Cho, G.C.3    Posner, G.H.4
  • 104
    • 2342603414 scopus 로고    scopus 로고
    • Induction of HDAC2 expression upon loss of APC in colorectal tumorigenesis
    • DOI 10.1016/S1535-6108(04)00114-X, PII S153561080400114X
    • Zhu P., Martin E., Mengwasser J., Schlag P., Janssen K. P, Gottlicher M.: Induction of HDAC2 expression upon loss of APC in colorectal tumorigenesis. Cancer Cell, 2004;5:455-463 (Pubitemid 38610247)
    • (2004) Cancer Cell , vol.5 , Issue.5 , pp. 455-463
    • Zhu, P.1    Martin, E.2    Mengwasser, J.3    Schlag, P.4    Janssen, K.-P.5    Gottlicher, M.6


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