Quercetin is able to demethylate the p16INK4a gene promoter

Chemotherapy

Volumn 55, Issue 1, 2008, Pages 6-10

  Tan, Sainan ^a,b,c,d   Wang, Chong ^a,b,c   Lu, Cailing ^a,c   Zhao, Baojian ^a,b,c   Cui, Yi ^a,b,c   Shi, Xinquan ^a,b,c   Ma, Xu ^a,b,c  

^a NATIONAL RESEARCH INSTITUTE FOR FAMILY PLANNING   (China)

^b GRADUATE SCHOOL OF PEKING UNION MEDICAL COLLEGE   (China)

^c WORLD HEALTH ORGANIZATION   (Switzerland)

^d Family Planning Institute of Hunan Province   (China)

Author keywords

Flavonoids; p16INK4a, demethylation; Quercetin

Indexed keywords

CYCLIN DEPENDENT KINASE INHIBITOR 2A; QUERCETIN;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER CELL; CANCER GROWTH; CANCER INHIBITION; CELL ASSAY; COLON CANCER; CONCENTRATION RESPONSE; CONTROLLED STUDY; DEMETHYLATION; DNA METHYLATION; DRUG EFFECT; GENE EXPRESSION; GENETIC TRANSCRIPTION; HUMAN; HUMAN CELL; IN VITRO STUDY; PRIORITY JOURNAL; PROMOTER REGION;

ANTIOXIDANTS; BASE SEQUENCE; CELL LINE, TUMOR; CYCLIN-DEPENDENT KINASE INHIBITOR P16; DNA METHYLATION; DNA PRIMERS; DOSE-RESPONSE RELATIONSHIP, DRUG; HUMANS; PROMOTER REGIONS, GENETIC; QUERCETIN; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; TIME FACTORS;

EID: 54949113264     PISSN: 00093157     EISSN: None     Source Type: Journal    
DOI: 10.1159/000166383     Document Type: Article

References (27)

1. American Cancer Society: Cancer Facts and Figures 2005. Atlanta, American Cancer Society, 2005.
2. American Cancer Society: Cancer Statistics 2004. Atlanta, American Cancer Society, 2004.
3. Armstrong F, Mathers JC: Kill and cure: dietary augmentation of immune defences against colon cancer. Proc Nutr Soc 2000;59:215-220.
4. Go VLW, Wong DA, Butrum R: Diet, nutrition, and cancer prevention: where are we going from here? J Nutr 2001;131(suppl):3121S-3126S.
5. Bingham S: Diet and colorectal cancer prevention. Biochem Soc Trans 2000;28:12-16.
6. Giovannucci E, Willett WC: Dietary factors and risk of colon cancer. Ann Med 1994;26:443-452.
7. Steinmetz K, Potter JD: Vegetables, fruit, and cancer prevention: a review. J Am Diet Assoc 1996;96:1027-1039. DOI: 10.1016/S0002-8223(96)00273-8.
8. World Cancer Research Fund International: Food, Nutrition, and the Prevention of Cancer: A Global Perspective. Washington, American Institute for Cancer Research, 1997.
9. Bloch A: Position of the American Dietetic Association: phytochemicals and functional foods. J Am Diet Assoc 1995;95:493-496. DOI: 10.1016/S0002- 8223(95)00130-1.
10. Scambia G: Quercetin enhances transforming growth factor beta 1 secretion by human ovarian cancer cells. Int J Cancer 1994;57:211-215.
11. Cook N, Samman S: Flavonoids - chemistry, metabolism, cardioprotective effects, and dietary sources. J Nutr Biochem 1996;7:66-76. DOI: 10.1016/0955-2863(95)00168-9.
12. Huber W, McDaniel L, Kaderlik K, Teitel C, Lang N, Kadlubar F: Chemoprotection against the formation of colon DNA adducts from the food-borne carcinogen 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) in the rat. Mutat Res 1997;376:115-122.
13. Hollman PC, van Trijp JM, Mengelers MJ, de Vries JH, Katan MB: Bioavailability of the dietary antioxidant flavonol quercetin in man. Cancer Lett 1997;114:139-140. DOI: 10.1016/S0304-3835(97)04644-2.
14. Denda A, Endoh T, Tang Q, Tsujiuchi T, Nakae D, Konishi Y: Prevention by inhibitors of arachidonic acid cascade of liver carcinogenesis, cirrhosis and oxidative DNA damage caused by a choline-deficient, L-amino acid-defined diet in rats. Mutat Res 1998;402:279-288.
15. Herman JG, Graff JR, Myohane S, Nelkin BFD, Baylin SB: Methylation-specific PCR: a novel PCR assay for methylation status of CpG islands. Proc Natl Acad Sci USA 1996;93:9821-9826.
16. Swafford DS, Middleton SK, Palmisano WA, Nikula KJ, Tesfaigzi J, Baylin SB, Herman JG, Belinsky SA: Frequent aberrant methylation of p16INK4a in primary rat lung tumors. Mol Cell Biol 1997;17:1366-1374.
17. Fang MZ, Wang Y, Ai N, Hou Z, Sun Y, Lu H, Welsh W, Yang CS: Tea polyphenol (-)-epigallocatechin-3-gallate inhibits DNA methyltransferase and reactivates methylation-silenced genes in cancer cell lines. Cancer Res 2003;63:7563-7570.
18. Hara E, Smith R, Parry D, Tahara H, Stone S, Peters G: Regulation of p16CDKN2 expression and its implications for cell immortalization and senescence. Mol Cell Biol 1996;16:859-867.
19. Modesitt SC, Ramirez P, Zu Z, Bodurka-Bevers D, Gershenson D, Wolf JK: In vitro and in vivo adenovirus-mediated p53 and p16 tumor suppressor therapy in ovarian cancer. Clin Cancer Res 2001;7:1765-1772.
20. Balch C, Montgomery JS, Paik HI, Kim S, Kim S, Huang TH, Nephew KP: New anticancer strategies: epigenetic therapies and biomarkers. Front Biosci 2005;10:1897-1931.
21. Merlo A, Herman JG, Mao L, Lee DJ, Gabrielson E, Burger PC, Baylin SB, Sidransky D: 5′ CpG island methylation is associated with transcriptional silencing of the tumour suppressor p16/CDKN2/MTS1 in human cancers. Nat Med 1995;1:686-692.
22. Thompson LU, Robb P, Serraino M, Cheung F: Mammalian lignan production from various foods. Nutr Cancer 1991;16:43-52.
23. Fang M, Chen D, Yang CS: Dietary polyphenols may affect DNA methylation. J Nutr 2007;137(suppl 1):223S-228S.
24. Jones PA, Taylor SM: Cellular differentiation, cytidine analogs and DNA methylation. Cell 1980;20:85-93.
25. Moschidis A, Papageorgiou A, Atmatzidis K, Tsalis K, Moschidis E, Livanis J, Chrysogelou E, Mourelatos D, Tsavdaridis D, Harlaftis N: Synergistic antitumor activity of oxaliplatin in combination with gemcitabine in pancreatic tumor-bearing mice. Chemotherapy 2007;53:153-159.
26. Rosenberg L: Pancreatic cancer: does octreotide offer any promise? Chemotherapy 2001;47(suppl 2):134-149.
27. Covey JM, Zaharko DS: Comparison of the in vitro cytotoxicity (L1210) of 5-aza-2′-deoxycytidine with its therapeutic and toxic effects in mice. Eur J Cancer Clin Oncol 1985;21:109-117.