Roles of histone acetyltransferases and deacetylases in gene regulation

BioEssays

Volumn 20, Issue 8, 1998, Pages 615-626

  Kuo, Min Hao ^a   Allis, C David ^a  

^a UNIVERSITY OF ROCHESTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACYLTRANSFERASE; HISTONE; HISTONE ACETYLTRANSFERASE; HISTONE DEACETYLASE; LYSINE; SACCHAROMYCES CEREVISIAE PROTEIN;

ACETYLATION; CHEMISTRY; GENE EXPRESSION REGULATION; GENETICS; HUMAN; METABOLISM; REVIEW; SACCHAROMYCES CEREVISIAE; TRANSACTIVATION;

ACETYLATION; ACETYLTRANSFERASES; GENE EXPRESSION REGULATION; HISTONE ACETYLTRANSFERASES; HISTONE DEACETYLASES; HISTONES; HUMANS; LYSINE; SACCHAROMYCES CEREVISIAE; SACCHAROMYCES CEREVISIAE PROTEINS; TRANS-ACTIVATION (GENETICS);

EUKARYOTA; SACCHAROMYCES CEREVISIAE;

EID: 0032142918     PISSN: 02659247     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1521-1878(199808)20:8<615::AID-BIES4>3.0.CO;2-H     Document Type: Review

References (85)

1. Felsenfeld G (1996) Chromatin unfolds. Cell 86:13-19.
2. Paranjape SM, Kamakaka RT, Kadonaga JT (1994) Role of chromatin structure in the regulation of transcription by RNA polymerase II. Annu Rev Biochem 63:265-297.
3. Shen X, Gorovsky MA (1996) Linker histone H1 regulates specific gene expression but not globaltranscription in vivo. Cell 86:475-483.
4. Schild C, Claret F-X, Wahli W, Wolffe AP (1993) A nucleosome-dependent static loop potentitates estrogen-regulated transcription from the Xenopus vitellogenin B1 promoter in vitro. EMBO J 12:423-433.
5. Tsukiyama T, Wu C (1997) Chromatin remodeling and transcription. Curr Opin Genet Dev 7:182-191.
6. Grunstein M (1997) Histone acetylation in chromatin structure and transcription. Nature 389:349-352.
7. Brownell JE, Allis CD (1996) Special HATs for special occasions: Linking histone acetylation to chromatin assembly and gene activation. Curr Opin Genet Dev 16:1176-1184.
8. Wolffe AP, Pruss D (1996) Targeting chromatin disruption: Transcription regulators that acetylate histones. Cell 84:817-819.
9. Hong L, Schroth GP, Matthews HR, Yau P, Bradbury EM (1993) Studies of the DNA binding properties of histone H4 amino terminus. Thermal denaturation studies reveal that acetylation markedly reduces the binding constant of the H4 "tail" to DNA. J Biol Chem 268:305-314.
10. Norton VG, Imai BS, Yau P, Bradbury EM (1989) Histone acetylation reduces nucleosome core particle linking number change. Cell 57:449-457.
11. Garcia-Ramirez M, Rocchini C, Ausio J (1995) Modulation of chromatin folding by histone acetylation. J Biol Chem 270:17923-17928.
12. Bauer WR, Hayes JJ, White JH, Wolffe AP (1994) Nucleosome structural changes due to acetylation. J Mol Biol 236:685-690.
13. Hecht A, Laroche T, Strahl-Bolsinger S, Gasser SM, Grunstein M (1995) Histone H3 and H4 N-termini interact with SIR3 and SIR4 proteins: A molecular model for the formation of heterochromatin in yeast. Cell 80:583-592.
14. Edmonson DG, Smith MM, Roth SY (1996) Repression domain of the yeast global repressor Tup1 directly interacts with histones H3 and H4. Genes Dev 10:1247-1259.
15. Luger K, Mader AW, Richmond RK, Sargent DF, Richmond TJ (1997) Crystal structure of the nucleosome core particle at 2.8 Å resolution. Nature 389:251-260.
16. Allfrey VG, Faulkner R, Mirsky AE (1964) Acetylation and methylation of histones and their possible role in the regulation of RNA synthesis. Proc Natl Acad Sci USA 51:786-794.
17. Vettese-Dadey M, Grant PA, Hebbes TR, Crane-Robinson C, Allis CD, Workman JL (1996) Acetylation of histone H4 plays a primary role in enhancing transcription factor binding to nucleosomal DNA in vitro. EMBO J 15:2508-2518.
18. Lee DY, Hayes JJ, Pruss D, Wolffe AP (1993) A positive role for histone acetylation in transcription factor access to nucleosomal DNA. Cell 72:73-84.
19. Ura K, Kurumizaka H, Dimitrov S, Almouzni G, Wolffe AP (1997) Histone acetylation: Influence on transcription by RNA polymerase, nucleosome mobility and positioning, and linker histone dependent transcriptional repression. EMBO J 14:2209-2216.
20. Brownell JE, Zhou J, Ranalli T, Kobayashi R, Edmondson DG, Roth SY (1996) Tetrahymena histone acetyltransferase A: A homolog to yeast Gcn5p linking histone acetylation to gene activation. Cell 84:843-851.
21. Kuo M-H, Brownell JE, Ranalli TA, Cook RG, Edmonson DG, Roth SY, Allis CD (1996) Transcirption-linked acetylation by Gcn5p of histones H3 and H4 at specific lysines. Nature 383:269-272.
22. Wang L, Mizzen C, Ying C, Candau R, Barlev N, Brownell J, Allis CD, Berger SL (1997) Histone acetyltransferase activity is conserved between yeast and human GCN5 and is required for complementation of growth and transcriptional activation. Mol Cell Biol 17:519-527.
23. Yang XJ, Ogryzko VV, Nishikawa J, Howard BH, Nakatani Y (1996) A p300/CBP-associated factor that competes with the adenoviral oncoprotein E1A. Nature 382:319-324.
24. Ogryzko VV, Schiltz RL, Russanova V, Howard BH, Nakatani Y (1996) The transcriptional coactivators p300 and CBP are histone acetyltransferases. Cell 87:953-959.
25. Mizzen CA, Yang X-J, Kokubo T, Brownell JE, Bannister AJ, Owen-Hughes T, Workman J, Berger SL, Kouzarides T, Nakatani Y, Allis CD (1996) The TAFII250 subunit of TFIID has histone acetyltransferase activity. Cell 87:1261-1270.
26. Spencer TE, Jenster G, Burcin MM, Allis CD, Zhou J, Mizzen CA, McKenna NJ, Onate SA, Tsai SY, Tsai MJ, O'Malley BW (1997) Steroid receptor coactivator-1 is a histone acetyltransferase. Nature 389:194-198.
27. Chen H, Lin RJ, Schiltz RL, Chakravarti D, Nash A, Nagy L, Privalsky ML, Nakatani Y, Evans RM (1997) Nuclear receptor coactivator actr is a novel histone acetyltransferase and forms a multimeric activation complex with P/CAF and CBP/p300. Cell 90:569-580.
28. Kleff S, Andrulis ED, Anderson CW, Sternglanz R (1995) Identification of a gene encoding a yeast histone H4 acetyltransferase. J Biol Chem 270:24674-24677.
29. Parthun MR, Widom J, Gottschling DE (1996) The major cytoplasmic hi stone acetyltransferase in yeast: links to chromatin replication and histone metabolism. Cell 87:85-94.
30. Smith ER, Eisen A, Gu W, Sattah M, Pannuti A, Zhou J, RG Cook, Allis CD (1998) ESA1 is a novel histone acetyltransferase essential for growth in yeast. Proc Natl Acad Sci USA 95:3561-3565.
31. 30a Yamamoto T, Horikosh M (1998) Novel substrate specificity of the histone acetyltransferase activity of HIV-1-Tat interactive protein Tip60. Job Biol 27:30595-30598.
32. Georgakopoulos T, Thireos G (1992) Two distinct yeast transcriptional activators require the function of the GCN5 protein to promote normal levels of transcription. EMBO J 11:4145-4152.
33. Grant PA, Duggan L, Cote J, Roberts SM, Brownell JE, Candau R, Ohba R, Owen-Hughes T, Allis CD, Winston F, Berger SL, Workman JL (1997) Yeast Gcn5 functions in two multisubunit complexes to acetylate nucleosomal histones: Characterization of an Ada complex and the SAGA (Spt/Ada) complex. Genes Dev 11:1640-1650.
34. Pollard KJ, Peterson CL (1997) Role for ADA/GCN5 products in antagonizing chromatin-mediated transcriptional repression. Mol Cell Biol 17:6212-6222.
35. Kuo M-H, Zhou J, Jambeck P, Churchill MA, Allis CD (1998) The histone acetyltransferase activity of yeast Gcn5p is required for the activation of target genes. Genes Dev 12:627-639.
36. Martens JA, Genereaux J, Saleh A, Brandl CJ (1996) Transcriptional activation by yeast PDR1p is inhibited by its association with NGG1p/ ADA3p. J Biol Chem 271:15884-15890.
37. Chiang YC, Komarnitsky P, Chase D, Denis CL (1996) ADR1 activation domains contact the histone acetyltransferase GCN5 and the core transcriptional factor TFIIB. J Biol Chem 271:32359-32365.
38. Candau R, Zhou JX, Allis CD, Berger SL (1997) Histone acetyltransferase activity and interaction with ADA2 are critical for GCN5 function in vivo. EMBO J 16:555-565.
39. Barlev NA, Candau R, Wang L, Darpino P, Silverman N, Berger SL (1995) Characterization of physical interactions of the putative transcriptional adaptor, ADA2, with acidic activation domains and TATA-binding protein. J Biol Chem 270:19337-19344.
40. Silverman N, Agapite J, Guarente L (1994) Yeast ADA2 protein binds to the VP16 protein activation domain and activates transcription. Proc Natl Acad Sci USA 91:11665-11668.
41. Shikama N, Lyon J, La Thangue NB (1997) The p300/CBP family: Integrating signals with transcription factors and chromatin. Trends Cell Biol 7:230-236.
42. Kamei Y, Xu L, Heinzel T, Torchia J, Kurokawa R, Gloss B, Lin SC, Rose DW, Glass CK, Rosenfeld MG (1996) A CBP integrator complex mediates transcriptional activation and AP-1 inhibition by nuclear receptors. Cell 85:403-414.
43. Bannister AJ, Kouzarides T (1996) The CBP co-activator is a histone acetyltransferase. Nature 384:641-643.
44. Borrow J, Stanton VP, Andreson JM, Becher R, Behm FG, Chaganti RSK, Civin CI, Disteche C, Dube I, Frischauf AM, Horsman D, Mitelman F, Wolinia S, Watmore AE, Housman DE (1996) The translocation t(8;16)(p11;p13) of acute myiloid leukemia fuses a putative acetyltransferases to the CREB-binding protein. Nature Genet 14: 33-41.
45. Reifsnyder C, Lowell J, Clarke A, Pillus L (1996) Yeast SAS silencing genes and human genes associated with AML and HIV-1 Tat interactions are homologous with acetyltransferases. Nature Genet 14:42-49.
46. Yao TP, Ku G, Zhou N, Scully R, Livingston DM (1996) The nuclear hormone receptor coactivator SRC-1 is a specific target of p300. Proc Natl Acad Sci USA 93:10626-10631.
47. Onate SA, Tsai SY, Tsai MJ, O'Malley BW (1995) Sequence and characterization of a coactivator for the steroid hormone receptor superfamily. Science 270:1354-1357.
48. Zawel L, Reinberg D (1995) Common themes in assembly and function of eukaryotic transcription complexes. Annu Rev Biochem 64:533-561.
49. Reese JC, Apone L, Walker SS, Griffin LA, Green MR (1994) Yeast TAFIIS in a multisubunit complex required for activated transcription. Nature 371:523-527.
50. Walker SS, Reese JC, Apone LM, Green MR (1996) Transcription activation in cells lacking TAFIIS. Nature 383:185-188.
51. Moqtaderi Z, Bai Y, Poon D, Weil PA, Struhl K (1996) TBP-associated factors are not generally required for transcriptional activation in yeast. Nature 383:188-191.
52. Shen WC, Green MR (1997) Yeast TAF(II)145 functions as a core promoter selectivity factor, not a general coactivator. Cell 90:615-624.
53. Walker SS, Shen WC, Reese JC, Apone LM, Green MR (1997) Yeast TAF(II)145 required for transcription of G1/S cyclin genes and regulated by the cellular growth state. Cell 90:607-614.
54. Godde JS, Nakatani Y, Wolffe AP (1995) The amino-terminal tails of the core histones and the translational position of the TATA box determine TBP/TFIIA association with nucleosomal DNA. Nucleic Acids Res 23:4557-4564.
55. Imbalzano AN, Kwon H, Green MR, Kingston RE (1994) Facilitated binding of TATA-binding protein to nucleosomal DNA. Nature 370:481-485.
56. Hilfiker A, Hilfiker-Kleiner D, Pannuti A, Lucchesi JC (1997) mot, a putative acetyl transferase gene related to the Tip60 and MOZ human genes and to the SAS genes of yeast, is required for dosage compensation in Drosophila. EMBO J 16:2054-2060.
57. Lucchesi JC (1996) Dosage compensation in Drosophila and the "complex" world of transcriptional regulation. BioEssays 18:541-547.
58. Bone JR, Lavender J, Richman R, Palmer MJ, Turner BM, Kuroda MI (1994) Acetylated histone H4 on the male X chromosome is associated with dosage compensation in Drosophila. Genes Dev 8:96-104.
59. Braunstein M, Rose AB, Holmes SG, Allis CD, Broach JR (1993) Transcriptional silencing in yeast is associated with reduced nucleosome acetylation. Genes Dev 7:592-604.
60. Braunstein M, Sobel RE, Allis CD, Turner BM, Broach JR (1996) Efficient transcriptional silencing in Saccharomyces cerevisiae requires a heterochromatin histone acetylation pattern. Mol Cell Biol 16:4349-4356.
61. Lin R, Allis CD, Elledge SJ (1996) PAT1, an evolutionary conserved acetyltransferase homologue, is required for multiple steps in the cell cycle. Genes Cells 1:923-942.
62. Ling X, Harkness TA, Schultz MC, Fisher-Adams G, Grunstein M (1996) Yeast histone H3 and H4 amino termini are important for nucleosome assembly in vivo and in vitro: Redundant and position-independent functions in assembly but not in gene regulation. Genes Dev 10:686-699.
63. Freeman L, Kurumizaka H, Wolffe AP (1996) Functional domains for assembly of histones H3 and H4 into the chromatin of Xenopus embryos. Proc Natl Acad Sci USA 93:12780-12785.
64. Verreault A, Kaufman PD, Kobayachi, R, Stillman B (1996) Nucleosome assembly by a complex of CAF-1 and acetylated histones H3/H4. Cell 87:95-104.
65. Taunton J, Hassig CA, Schreiber SL (1996) A mammalian histone deacetylase related to the yeast transcriptional regulator Rpd3p. Science 272:408-411.
66. Roth SY, Allis CD (1996) Histone acetylation and chromatin assembly: A singer escort multiple dances? Cell 87:5-8.
67. Vidal M, Gaber RF (1991) RPD3 encodes a second factor required to achieve maximum positive and negative transcriptional states in Saccharomyces cerevisiae. Mol Cell Biol 11:6317-6327.
68. Qian YW, Wang YC, Hollingsworth Jr RE, Jones D, Ling N, Lee EY (1993) A retinoblastoma-binding protein related to a negative regulator of Ras in yeast. Nature 364:648-652.
69. Carmen AA, Rundlett SE, Grunstein M (1996) HDA1 and HDA3 are components of a yeast histone deacetylase (HDA) complex. J Biol Chem 271:15837-15844.
70. Rundlett SE, Carmen AA, Kobayashi R, Bavykin S, Turner BM, Grunstein M (1996) HDA1 and RPD3 are members of distinct yeast histone deacetylase complexes that regulate silencing and transcription. Proc Natl Acad Sci USA 93:14503-14508.
71. Kasten MM, Dorland S, Stillman DJ (1997) A large protein complex containing the yeast Sin3p and Rpd3p transcriptional regulators. Mol Cell Biol 17:4852-4858.
72. Pazin MJ, Kadonaga JT (1997b) What's up and down with histone deacetylation and transcription? Cell 89:325-328.
73. Wolffe AP (1997) Sinful repression. Nature 387:16-17.
74. Gu W, Roeder RG (1997) Activation of p53 sequence-specific DNA binding by acetylation of the p53 C-terminal domain. Cell 90:595-606.
75. Imhof A, Yang XJ, Ogryzko VV, Nakatani Y, Wolffe AP, Ge H (1997) Acetylation of general transcription factors by histone acetyltransferases. Curr Biol 7:689-692.
76. Jiang YW, Stillman DJ (1996) Epigenetic effects on yeast transcription caused by mutations in an actin-related protein present in the nucleus. Genes Dev 10:604-619.
77. Wang L, Liu L, Berger SL (1998) Critical residues for histone acetylation by Gcn5, functioning in Ada and SAGA complexes, are also required for transcriptional function in vivo. Genes Dev 12:640-653.
78. Kim YJ, Bjorklund S, Li Y, Sayre MH, Kornberg RD (1994) A multiprotein mediator of transcriptional activation and its interaction with the C-terminal repeat domain of RNA polymerase II. Cell 77:599-608.
79. Koleske AJ, Young RA (1994) An RNA polymerase II holoenzyme responsive to activators. Nature 368:466-469.
80. Thompson CM, Koleske AJ, Chao DM, Young RA (1993) A multisubunit complex associated with the RNA polymerase II CTD and TATA-binding protein in yeast. Cell 73:1361-1375.
81. Roberts SM, Winston F (1997) Essential functional interactions of SAGA, a Saccharomyces cerevisiae complex of Spt, Ada, and Gcn5 proteins, with the Snf/Swi and Srb/mediator complexes. Genetics 147:451-465.
82. Burns LG, Peterson CL (1997) The yeast SWI-SNF complex facilitates binding of a transcriptional activator to nucleosomal sites in vivo. Mol Cell Biol 17:4811-4819.
83. Bradbury EM (1992) Reversible histone modification and the chromosome cell cycle. BioEssays 14:9-16.
84. Zhang W, Bone JR, Edmonson DG, Turner BM, Roth SY (1998) Essential and redundant functions of histone acetylation revealed by mutation of target lysines and loss of the Gcn5p acetyltransferase. EMBO J 17:3155-3167.
85. Verreault A, Kaufman RD, Kobayashi R, Stillman B (1998) Nucleosomal DNA regulates the core-histone-binding subunit of the human Hatl acetyltransferase. Curr Biol 15:96-108.