-
1
-
-
34249279527
-
Stability and flexibility of epigenetic gene regulation in mammalian development
-
PubMed doi:10.1038/nature05918
-
Reik W. Stability and flexibility of epigenetic gene regulation in mammalian development. Nature 2007;447:425-432 PubMed doi:10.1038/nature05918.
-
(2007)
Nature
, vol.447
, pp. 425-432
-
-
Reik, W.1
-
2
-
-
25844530426
-
Epigenetic changes in solid and hematopoietic tumors
-
DOI 10.1053/j.seminoncol.2005.07.003, PII S0093775405002708, Cancer Epigenetics
-
Toyota M, Issa JP. Epigenetic changes in solid and hematopoietic tumors. Semin Oncol 2005;32:521-530 PubMed doi:10.1053/j.seminoncol.2005.07.003. (Pubitemid 41396429)
-
(2005)
Seminars in Oncology
, vol.32
, Issue.5
, pp. 521-531
-
-
Toyota, M.1
Issa, J.-P.J.2
-
3
-
-
4043181214
-
Cancer genes and the pathways they control
-
DOI 10.1038/nm1087
-
Vogelstein B, Kinzler KW. Cancer genes and the pathways they control. Nat Med 2004;10:789-799 PubMed doi:10.1038/nm1087. (Pubitemid 39070849)
-
(2004)
Nature Medicine
, vol.10
, Issue.8
, pp. 789-799
-
-
Vogelstein, B.1
Kinzler, K.W.2
-
4
-
-
0030592517
-
Lessons from hereditary colorectal cancer
-
DOI 10.1016/S0092-8674(00)81333-1
-
Kinzler KW, Vogelstein B. Lessons from hereditary colorectal cancer. Cell 1996;87:159-70. PubMed doi:10.1016/S0092-8674(00)81333-81341 (Pubitemid 26358996)
-
(1996)
Cell
, vol.87
, Issue.2
, pp. 159-170
-
-
Kinzler, K.W.1
Vogelstein, B.2
-
5
-
-
36248962105
-
The genomic landscapes of human breast and colorectal cancers
-
DOI 10.1126/science.1145720
-
Wood LD, Parsons DW, Jones S, et al. The genomic landscapes of human breast and colorectal cancers. Science 2007;318:1108-1113 PubMed doi:10.1126/science.1145720. (Pubitemid 350134889)
-
(2007)
Science
, vol.318
, Issue.5853
, pp. 1108-1113
-
-
Wood, L.D.1
Parsons, D.W.2
Jones, S.3
Lin, J.4
Sjoblom, T.5
Leary, R.J.6
Shen, D.7
Boca, S.M.8
Barber, T.9
Ptak, J.10
Silliman, N.11
Szabo, S.12
Dezso, Z.13
Ustyanksky, V.14
Nikolskaya, T.15
Nikolsky, Y.16
Karchin, R.17
Wilson, P.A.18
Kaminker, J.S.19
Zhang, Z.20
Croshaw, R.21
Willis, J.22
Dawson, D.23
Shipitsin, M.24
Willson, J.K.V.25
Sukumar, S.26
Polyak, K.27
Ben, H.P.28
Pethiyagoda, C.L.29
Pant, P.V.K.30
Ballinger, D.G.31
Sparks, A.B.32
Hartigan, J.33
Smith, D.R.34
Suh, E.35
Papadopoulos, N.36
Buckhaults, P.37
Markowitz, S.D.38
Parmigiani, G.39
Kinzler, K.W.40
Velculescu, V.E.41
Vogelstein, B.42
more..
-
6
-
-
55549101623
-
DNA sequencing of a cytogenetically normal acute myeloid leukaemia genome
-
PubMed doi:10.1038/nature07485
-
Ley TJ, Mardis ER, Ding L, et al. DNA sequencing of a cytogenetically normal acute myeloid leukaemia genome. Nature 2008;456:66-72. PubMed doi:10.1038/nature07485.
-
(2008)
Nature
, vol.456
, pp. 66-72
-
-
Ley, T.J.1
Mardis, E.R.2
Ding, L.3
-
7
-
-
33847065486
-
The Epigenomics of Cancer
-
DOI 10.1016/j.cell.2007.01.029, PII S0092867407001274
-
Jones PA, Baylin SB. The epigenomics of cancer. Cell 2007;128:683-692 PubMed doi:10.1016/j.cell.2007.01.029. (Pubitemid 46273572)
-
(2007)
Cell
, vol.128
, Issue.4
, pp. 683-692
-
-
Jones, P.A.1
Baylin, S.B.2
-
8
-
-
0036144048
-
DNA methylation patterns and epigenetic memory
-
DOI 10.1101/gad.947102
-
Bird A. DNA methylation patterns and epigenetic memory. Genes Dev 2002;16:6-21. PubMed doi:10.1101/gad.947102. (Pubitemid 34049633)
-
(2002)
Genes and Development
, vol.16
, Issue.1
, pp. 6-21
-
-
Bird, A.1
-
9
-
-
35548953686
-
An elaborate pathway required for Ras-mediated epigenetic silencing
-
DOI 10.1038/nature06251, PII NATURE06251
-
Gazin C, Wajapeyee N, Gobeil S, Virbasius CM, Green MR. An elaborate pathway required for Ras-mediated epigenetic silencing. Nature 2007;449:1073-1077 PubMed doi:10.1038/nature06251. (Pubitemid 350014604)
-
(2007)
Nature
, vol.449
, Issue.7165
, pp. 1073-1077
-
-
Gazin, C.1
Wajapeyee, N.2
Gobeil, S.3
Virbasius, C.-M.4
Green, M.R.5
-
10
-
-
67449113768
-
Cancer DNA methylation: Molecular mechanisms and clinical implications
-
McCabe MT, Brandes JC, Vertino PM. Cancer DNA methylation: molecular mechanisms and clinical implications. Clin Cancer Res 2009;15:3927-3937
-
(2009)
Clin Cancer Res
, vol.15
, pp. 3927-3937
-
-
McCabe, M.T.1
Brandes, J.C.2
Vertino, P.M.3
-
11
-
-
33644856123
-
Epigenetic therapy of cancer: Past, present and future
-
PubMed doi:10.1038/nrd1930
-
Yoo CB, Jones PA. Epigenetic therapy of cancer: past, present and future. Nat Rev Drug Discov 2006;5:37-50. PubMed doi:10.1038/nrd1930.
-
(2006)
Nat Rev Drug Discov
, vol.5
, pp. 37-50
-
-
Yoo, C.B.1
Jones, P.A.2
-
12
-
-
34250213859
-
DNA methylation as a therapeutic target in cancer
-
PubMed doi:10.1158/1078-0432.CCR-06-2076
-
Issa JP. DNA methylation as a therapeutic target in cancer. Clin Cancer Res 2007;13:1634-7. PubMed doi:10.1158/1078-0432.CCR-06-2076.
-
(2007)
Clin Cancer Res
, vol.13
, pp. 1634-1637
-
-
Issa, J.P.1
-
13
-
-
0035839126
-
Epigenetic reprogramming in mammalian development
-
DOI 10.1126/science.1063443
-
Reik W, Dean W, Walter J. Epigenetic reprogramming in mammalian development. Science 2001;293:1089-1093 PubMed doi:10.1126/science.1063443. (Pubitemid 32758081)
-
(2001)
Science
, vol.293
, Issue.5532
, pp. 1089-1093
-
-
Reik, W.1
Dean, W.2
Walter, J.3
-
14
-
-
0035839106
-
Nuclear cloning and epigenetic reprogramming of the genome
-
DOI 10.1126/science.1063206
-
Rideout WM III, Eggan K, Jaenisch R. Nuclear cloning and epigenetic reprogramming of the genome. Science 2001;293:1093-1098 PubMed doi:10.1126/science.1063206. (Pubitemid 32758082)
-
(2001)
Science
, vol.293
, Issue.5532
, pp. 1093-1098
-
-
Rideout III, W.M.1
Eggan, K.2
Jaenisch, R.3
-
15
-
-
3543073392
-
Reprogramming of a melanoma genome by nuclear transplantation
-
DOI 10.1101/gad.1213504
-
Hochedlinger K, Blelloch R, Brennan C, et al. Reprogramming of a melanoma genome by nuclear transplantation. Genes Dev 2004;18:1875-1885 PubMed doi:10.1101/gad.1213504. (Pubitemid 39025097)
-
(2004)
Genes and Development
, vol.18
, Issue.15
, pp. 1875-1885
-
-
Hochedlinger, K.1
Blelloch, R.2
Brennan, C.3
Yamada, Y.4
Kim, M.5
Chin, L.6
Jaenisch, R.7
-
16
-
-
0018581647
-
Multiple new phenotypes induced in 10T 1/2 and 3T3 cells treated with 5-azacytidine
-
Taylor SM, Jones PA. Multiple new phenotypes induced in 10T1/2 and 3T3 cells treated with 5-azacytidine. Cell 1979;17:771-9. PubMed doi:10.1016/0092-8674(79)90317-90319 (Pubitemid 9252286)
-
(1979)
Cell
, vol.17
, Issue.4
, pp. 771-779
-
-
Taylor, S.M.1
Jones, P.A.2
-
17
-
-
0018860957
-
Cellular differentiation, cytidine analogs and DNA methylation
-
Jones PA, Taylor SM. Cellular differentiation, cytidine analogs and DNA methylation. Cell 1980;20:85-93. PubMed doi:10.1016/0092-8674(80)90237-90238 (Pubitemid 10117303)
-
(1980)
Cell
, vol.20
, Issue.1
, pp. 85-93
-
-
Jones, P.A.1
Taylor, S.M.2
-
18
-
-
43749124047
-
Concentrations of the DNA methyltransferase inhibitor 5-fluoro-2′- Deoxycytidine (FdCyd) and its cytotoxic metabolites in plasma of patients treated with FdCyd and tetrahydrouridine (THU)
-
DOI 10.1007/s00280-007-0603-8
-
Beumer JH, Parise RA, Newman EM, et al. Concentrations of the DNA methyltransferase inhibitor 5-fluoro-2′-deoxycytidine (FdCyd) and its cytotoxic metabolites in plasma of patients treated with FdCyd and tetrahydrouridine (THU). Cancer Chemother Pharmacol 2008;62:363-8. PubMed doi :10.1007/s00280-007-0603-608 (Pubitemid 351692084)
-
(2008)
Cancer Chemotherapy and Pharmacology
, vol.62
, Issue.2
, pp. 363-368
-
-
Beumer, J.H.1
Parise, R.A.2
Newman, E.M.3
Doroshow, J.H.4
Synold, T.W.5
Lenz, H.-J.6
Egorin, M.J.7
-
19
-
-
27644597195
-
Comparison of biological effects of non-nucleoside DNA methylation inhibitors versus 5-aza-2′-deoxycytidine
-
DOI 10.1158/1535-7163.MCT-05-0172
-
Chuang JC, Yoo CB, Kwan JM, et al. Comparison of biological effects of non-nucleoside DNA methylation inhibitors versus 5-aza-2′-deoxycytidine. Mol Cancer Ther 2005;4:1515-20. PubMed doi:10.1158/1535-7163.MCT-05-0172. (Pubitemid 41556433)
-
(2005)
Molecular Cancer Therapeutics
, vol.4
, Issue.10
, pp. 1515-1520
-
-
Chuang, J.C.1
Yoo, C.B.2
Kwan, J.M.3
Li, T.W.H.4
Liang, G.5
Yang, A.S.6
Jones, P.A.7
-
20
-
-
33645086120
-
Functional diversity of DNA methyltransferase inhibitors in human cancer cell lines
-
PubMed doi:10.1158/0008-5472.CAN-05-2821
-
Stresemann C, Brueckner B, Musch T, Stopper H, Lyko F. Functional diversity of DNA methyltransferase inhibitors in human cancer cell lines. Cancer Res 2006;66:2794-800. PubMed doi:10.1158/0008-5472.CAN-05-2821.
-
(2006)
Cancer Res
, vol.66
, pp. 2794-2800
-
-
Stresemann, C.1
Brueckner, B.2
Musch, T.3
Stopper, H.4
Lyko, F.5
-
21
-
-
0027198976
-
Increased cytosine DNA-methyltransferase activity during colon cancer progression
-
Issa JP, Vertino PM, Wu J, et al. Increased cytosine DNA- methyltransferase activity during colon cancer progression. J Natl Cancer Inst 1993;85:1235-1240 PubMed doi:10.1093/jnci/85.15.1235. (Pubitemid 23223530)
-
(1993)
Journal of the National Cancer Institute
, vol.85
, Issue.15
, pp. 1235-1240
-
-
Issa, J.-P.J.1
Vertino, P.M.2
Wu, J.3
Sazawal, S.4
Celano, P.5
Nelkin, B.D.6
Hamilton, S.R.7
Baylin, S.B.8
-
22
-
-
0034658196
-
Differential mRNA expression of the human DNA methyltransferases (DNMTs) 1, 3a and 3b during the G(0)/G(1) to S phase transition in normal and tumor cells
-
PubMed doi:10.1093/nar/28.10.2108
-
Robertson KD, Keyomarsi K, Gonzales FA, Velicescu M, Jones PA. Differential mRNA expression of the human DNA methyltransferases (DNMTs) 1, 3a and 3b during the G(0)/G(1) to S phase transition in normal and tumor cells. Nucleic Acids Res 2000;28:2108-2113 PubMed doi:10.1093/nar/28.10.2108.
-
(2000)
Nucleic Acids Res
, vol.28
, pp. 2108-2113
-
-
Robertson, K.D.1
Keyomarsi, K.2
Gonzales, F.A.3
Velicescu, M.4
Jones, P.A.5
-
23
-
-
18344390653
-
DNMT1 and DNMT3b cooperate to silence genes in human cancer cells
-
DOI 10.1038/416552a
-
Rhee I, Bachman KE, Park BH, et al. DNMT1 and DNMT3b cooperate to silence genes in human cancer cells. Nature 2002;416:552-556 PubMed doi:10.1038/416552a. (Pubitemid 34288859)
-
(2002)
Nature
, vol.416
, Issue.6880
, pp. 552-556
-
-
Rhee, I.1
Bachman, K.E.2
Park, B.H.3
Jair, K.-W.4
Yen, R.-W.C.5
Schuebel, K.E.6
Cui, H.7
Feinberg, A.P.8
Lengauer, C.9
Kinzler, K.W.10
Baylin, S.B.11
Vogelstein, B.12
-
24
-
-
42249104213
-
A phase I biological study of MG98, an oligodeoxynucleotide antisense to DNA methyltransferase 1, in patients with high-risk myelodysplasia and acute myeloid leukemia
-
DOI 10.1158/1078-0432.CCR-07-1320
-
Klisovic RB, Stock W, Cataland S, et al. A phase I biological study of MG98, an oligodeoxynucleotide antisense to DNA methyltransferase1, in patients with high-risk myelodysplasia and acute myeloid leukemia. Clin Cancer Res 2008;14:2444-9. PubMed doi:10.1158/1078-0432.CCR-07-1320. (Pubitemid 351551079)
-
(2008)
Clinical Cancer Research
, vol.14
, Issue.8
, pp. 2444-2449
-
-
Klisovic, R.B.1
Stock, W.2
Cataland, S.3
Klisovic, M.I.4
Liu, S.5
Blum, W.6
Green, M.7
Odenike, O.8
Godley, L.9
Vanden Burgt, J.10
Van Laar, E.11
Cullen, M.12
Macleod, A.R.13
Besterman, J.M.14
Reid, G.K.15
Byrd, J.C.16
Marcucci, G.17
-
25
-
-
0028151343
-
Toxicity of 5-aza-2′-deoxycytidine to mammalian cells is mediated primarily by covalent trapping of DNA methyltransferase rather than DNA demethylation
-
Juttermann R, Li E, Jaenisch R. Toxicity of 5-aza-2′-deoxycytidine to mammalian cells is mediated primarily by covalent trapping of DNA methyltransferase rather than DNA demethylation. Proc Natl Acad Sci U S A 1994;91:11797-11801 PubMed doi:10.1073/pnas.91.25.11797. (Pubitemid 24985095)
-
(1994)
Proceedings of the National Academy of Sciences of the United States of America
, vol.91
, Issue.25
, pp. 11797-11801
-
-
Juttermann, R.1
Li, E.2
Jaenisch, R.3
-
26
-
-
60249094793
-
Mechanisms of resistance to 5-aza-2′-deoxycytidine in human cancer cell lines
-
Qin T, Jelinek J, Si J, Shu J, Issa JP. Mechanisms of resistance to 5-aza-2′-deoxycytidine in human cancer cell lines. Blood 2008;113:659-667
-
(2008)
Blood
, vol.113
, pp. 659-667
-
-
Qin, T.1
Jelinek, J.2
Si, J.3
Shu, J.4
Issa, J.P.5
-
27
-
-
33744805399
-
Specific activation of microRNA-127 with downregulation of the proto-oncogene BCL6 by chromatin-modifying drugs in human cancer cells
-
DOI 10.1016/j.ccr.2006.04.020, PII S1535610806001437
-
Saito Y, Liang G, Egger G, et al. Specific activation of microRNA-127 with downregulation of the proto-oncogene BCL6 by chromatin-modifying drugs in human cancer cells. Cancer Cell 2006;9:435-443 PubMed doi:10.1016/j.ccr.2006.04. 020. (Pubitemid 43832188)
-
(2006)
Cancer Cell
, vol.9
, Issue.6
, pp. 435-443
-
-
Saito, Y.1
Liang, G.2
Egger, G.3
Friedman, J.M.4
Chuang, J.C.5
Coetzee, G.A.6
Jones, P.A.7
-
28
-
-
0035799382
-
Changes in DNA methylation in neoplasia: Pathophysiology and therapeutic implications
-
Santini V, Kantarjian HM, Issa JP. Changes in DNA methylation in neoplasia: pathophysiology and therapeutic implications. Ann Intern Med 2001;134:573-586 PubMed. (Pubitemid 32245319)
-
(2001)
Annals of Internal Medicine
, vol.134
, Issue.7
, pp. 573-586
-
-
Santini, V.1
Kantarjian, H.M.2
Issa, J.-P.3
-
29
-
-
60249094793
-
Mechanisms of resistance to 5-aza-2′-deoxycytidine in human cancer cell lines
-
Qin T, Jelinek J, Si J, Shu J, Issa JP. Mechanisms of resistance to 5-aza-2′-deoxycytidine in human cancer cell lines. Blood 2009;113:659-667
-
(2009)
Blood
, vol.113
, pp. 659-667
-
-
Qin, T.1
Jelinek, J.2
Si, J.3
Shu, J.4
Issa, J.P.5
-
30
-
-
0037093195
-
Randomized controlled trial of azacitidine in patients with the myelodysplastic syndrome: A study of the cancer and leukemia group B
-
DOI 10.1200/JCO.2002.04.117
-
Silverman LR, Demakos EP, Peterson BL, et al. Randomized controlled trial of azacitidine in patients with the myelodysplastic syndrome: a study of the cancer and leukemia group B. J Clin Oncol 2002;20:2429-2440 PubMed doi:10.1200/JCO.2002.04.117. (Pubitemid 34525728)
-
(2002)
Journal of Clinical Oncology
, vol.20
, Issue.10
, pp. 2429-2440
-
-
Silverman, L.R.1
Demakos, E.P.2
Peterson, B.L.3
Kornblith, A.B.4
Holland, J.C.5
Odchimar-Reissig, R.6
Stone, R.M.7
Nelson, D.8
Powell, B.L.9
Decastro, C.M.10
Ellerton, J.11
Larson, R.A.12
Schiffer, C.A.13
Holland, J.F.14
-
31
-
-
17444452612
-
Low-dose 5-Aza-2'-deoxycytidine, a DNA hypomethylating agent, for the treatment of high-risk myelodysplastic syndrome: A multicenter phase II study in elderly patients
-
Wijermans P, Lubbert M, Verhoef G, et al. Low-dose 5-aza-2′- deoxycytidine, a DNA hypomethylating agent, for the treatment of high-risk myelodysplastic syndrome: a multicenter phase II study in elderly patients. J Clin Oncol 2000;18:956-962 PubMed. (Pubitemid 30123770)
-
(2000)
Journal of Clinical Oncology
, vol.18
, Issue.5
, pp. 956-962
-
-
Wijermans, P.1
Lubbert, M.2
Verhoef, G.3
Bosly, A.4
Ravoet, C.5
Andre, M.6
Ferrant, A.7
-
32
-
-
10744233452
-
Phase 1 study of low-dose prolonged exposure schedules of the hypomethylating agent 5-aza-2′-deoxycytidine (decitabine) in hematopoietic malignancies
-
DOI 10.1182/blood-2003-03-0687
-
Issa JP, Garcia-Manero G, Giles FJ, et al. Phase I study of low-dose prolonged exposure schedules of the hypomethylating agent 5-aza-2′- deoxycytidine (Decitabine) in hematopoietic malignancies. Blood 2004;103:1635-40. PubMed doi:10.1182/blood-2003-03-0687. (Pubitemid 38268953)
-
(2004)
Blood
, vol.103
, Issue.5
, pp. 1635-1640
-
-
Issa, J.-P.J.1
Garcia-Manero, G.2
Giles, F.J.3
Mannari, R.4
Thomas, D.5
Faderl, S.6
Bayar, E.7
Lyons, J.8
Rosenfeld, C.S.9
Cortes, J.10
Kantarjian, H.M.11
-
33
-
-
62849104641
-
Efficacy of azacitidine compared with that of conventional care regimens inthe treatment of higher-risk myelodysplastic syndromes: A randomised, open-label, phase III study
-
Fenaux P, Mufti GJ, Hellstrom-Lindberg E, et al. Efficacy of azacitidine compared with that of conventional care regimens inthe treatment of higher-risk myelodysplastic syndromes: a randomised, open-label, phase III study. Lancet Oncol 2009;10:223-232
-
(2009)
Lancet Oncol
, vol.10
, pp. 223-232
-
-
Fenaux, P.1
Mufti, G.J.2
Hellstrom-Lindberg, E.3
-
34
-
-
33646071894
-
Decitabine improves patient outcomes in myelodysplastic syndromes: Results of a phase III randomized study
-
Kantarjian H, Issa JP, Rosenfeld CS, et al. Decitabine improves patient outcomes in myelodysplastic syndromes: results of a phase III randomized study. Cancer 2006;106:1794-1803
-
(2006)
Cancer
, vol.106
, pp. 1794-1803
-
-
Kantarjian, H.1
Issa, J.P.2
Rosenfeld, C.S.3
-
35
-
-
63149172482
-
Low dose decitabine versus best supportive care in elderly patients with Intermediate or high risk MDS not eligible for intensive chemotherapy: Final results of the randomized phase III study (06011) of the EORTC leukemia and German MDS study groups
-
abstr. 26
-
Wijermans P, Suciu S, Baila L, et al. Low dose decitabine versus best supportive care in elderly patients with Intermediate or high risk MDS not eligible for intensive chemotherapy: final results of the randomized phase III study (06011) of the EORTC leukemia and German MDS study groups. Blood (ASH Annual Meeting Abstracts) [abstr. 26] 2008;112.
-
(2008)
Blood (ASH Annual Meeting Abstracts)
, vol.112
-
-
Wijermans, P.1
Suciu, S.2
Baila, L.3
-
36
-
-
33947281469
-
Survival advantage with decitabine versus intensive chemotherapy in patients with higher risk myelodysplastic syndrome: Comparison with historical experience
-
DOI 10.1002/cncr.22508
-
Kantarjian HM, O'Brien S, Huang X, et al. Survival advantage with decitabine versus intensive chemotherapy in patients with higher risk myelodysplastic syndrome: comparison with historical experience. Cancer 2007;109:1133-1137 (Pubitemid 46435392)
-
(2007)
Cancer
, vol.109
, Issue.6
, pp. 1133-1137
-
-
Kantarjian, H.M.1
O'Brien, S.2
Huang, X.3
Garcia-Manero, G.4
Ravandi, F.5
Cortes, J.6
Shan, J.7
Davisson, J.8
Bueso-Ramos, C.E.9
Issa, J.-P.10
-
37
-
-
33846011361
-
Results of a randomized study of 3 schedules of low-dose decitabine in higher-risk myelodysplastic syndrome and chronic myelomonocytic leukemia
-
DOI 10.1182/blood-2006-05-021162
-
Kantarjian H, Oki Y, Garcia-Manero G, et al. Results of a randomized study of 3 schedules of low-dose decitabine in higher-risk myelodysplastic syndrome and chronic myelomonocytic leukemia. Blood 2007;109:52-7. PubMed doi:10.1182/blood-2006-05-021162. (Pubitemid 46053042)
-
(2007)
Blood
, vol.109
, Issue.1
, pp. 52-57
-
-
Kantarjian, H.1
Oki, Y.2
Garcia-Manero, G.3
Huang, X.4
O'Brien, S.5
Cortes, J.6
Faderl, S.7
Bueso-Ramos, C.8
Ravandi, F.9
Estrov, Z.10
Ferrajoli, A.11
Wierda, W.12
Shan, J.13
Davis, J.14
Giles, F.15
Saba, H.I.16
Issa, J.-P.J.17
-
38
-
-
41349083325
-
Induction of hypomethylation and molecular response after decitabine therapy in patients with chronic myelomonocytic leukemia
-
PubMed doi:10.1182/blood-2007-07-103960
-
Oki Y, Jelinek J, Shen L, Kantarjian HM, Issa JP. Induction of hypomethylation and molecular response after decitabine therapy in patients with chronic myelomonocytic leukemia. Blood 2008;111:2382-4. PubMed doi:10.1182/blood-2007-07-103960.
-
(2008)
Blood
, vol.111
, pp. 2382-2384
-
-
Oki, Y.1
Jelinek, J.2
Shen, L.3
Kantarjian, H.M.4
Issa, J.P.5
-
40
-
-
33846117560
-
Decitabine-Bedside to bench
-
DOI 10.1016/j.critrevonc.2006.07.010, PII S1040842806001697
-
Oki Y, Aoki E, Issa JP. Decitabine-bedside to bench. Crit Rev Oncol Hematol 2007;61:140-152 PubMed doi:10.1016/j.critrevonc.2006.07.010. (Pubitemid 46073782)
-
(2007)
Critical Reviews in Oncology/Hematology
, vol.61
, Issue.2
, pp. 140-152
-
-
Oki, Y.1
Aoki, E.2
Issa, J.-P.J.3
-
41
-
-
34948845116
-
Safety and clinical activity of the combination of 5-azacytidine, valproic acid, and all-trans retinoic acid in acute myeloid leukemia and myelodysplastic syndrome
-
DOI 10.1182/blood-2007-03-078576
-
Soriano AO, Yang H, Faderl S, et al. Safety and clinical activity of the combination of 5-azacytidine, valproic acid and all-trans retinoic acid in acute myeloid leukemia and myelodysplastic syndrome. Blood 2007;110:2302-2308 (Pubitemid 47523148)
-
(2007)
Blood
, vol.110
, Issue.7
, pp. 2302-2308
-
-
Soriano, A.O.1
Yang, H.2
Faderl, S.3
Estrov, Z.4
Giles, F.5
Ravandi, F.6
Cortes, J.7
Wierda, W.G.8
Ouzounian, S.9
Quezada, A.10
Pierce, S.11
Estey, E.H.12
Issa, J.-P.J.13
Kantarjian, H.M.14
Garcia-Manero, G.15
-
42
-
-
33744918070
-
DNA methylation changes after 5-aza-2′-deoxycytidine therapy in patients with leukemia
-
DOI 10.1158/0008-5472.CAN-05-2385
-
Yang AS, Doshi KD, Choi SW, et al. DNA methylation changes after 5-aza-2′-deoxycytidine therapy in patients with leukemia. Cancer Res 2006;66:5495-503. PubMed doi:10.1158/0008-5472.CAN-05-2385. (Pubitemid 43844978)
-
(2006)
Cancer Research
, vol.66
, Issue.10
, pp. 5495-5503
-
-
Yang, A.S.1
Doshi, K.D.2
Choi, S.-W.3
Mason, J.B.4
Mannari, R.K.5
Gharybian, V.6
Luna, R.7
Rashid, A.8
Shen, L.9
Estecio, M.R.H.10
Kantarjian, H.M.11
Garcia-Manero, G.12
Issa, J.-P.J.13
-
43
-
-
0037108309
-
Demethylation of a hypermethylated P15/INK4B gene in patients with myelodysplastic syndrome by 5-Aza-2′-deoxycytidine (decitabine) treatment
-
PubMed doi :10.1182/blood.V100.8.2957
-
Daskalakis M, Nguyen TT, Nguyen C, et al. Demethylation of a hypermethylated P15/INK4B gene in patients with myelodysplastic syndrome by 5-Aza-2′-deoxycytidine (decitabine) treatment. Blood 2002;100: 2957-2964 PubMed doi :10.1182/blood.V100.8.2957.
-
(2002)
Blood
, vol.100
, pp. 2957-2964
-
-
Daskalakis, M.1
Nguyen, T.T.2
Nguyen, C.3
-
44
-
-
33745714230
-
Combined DNA methyltransferase and histone deacetylase inhibition in the treatment of myeloid neoplasms
-
PubMed doi:10.1158/0008-5472.CAN-06-0080
-
Gore SD, Baylin S, Sugar E, et al. Combined DNA methyltransferase and histone deacetylase inhibition in the treatment of myeloid neoplasms. Cancer Res 2006;66:6361-9. PubMed doi:10.1158/0008-5472.CAN-06-0080.
-
(2006)
Cancer Res
, vol.66
, pp. 6361-6369
-
-
Gore, S.D.1
Baylin, S.2
Sugar, E.3
-
45
-
-
34548529948
-
Phase I study of decitabine alone or in combination with valproic acid in acute myeloid leukemia
-
DOI 10.1200/JCO.2006.09.4169
-
Blum W, Klisovic RB, Hackanson B, et al. Phase I study of decitabine alone or in combination with valproic acid in acute myeloid leukemia. J Clin Oncol 2007;25:3884-3891 PubMed doi:10.1200/JCO.2006.09.4169. (Pubitemid 47477265)
-
(2007)
Journal of Clinical Oncology
, vol.25
, Issue.25
, pp. 3884-3891
-
-
Blum, W.1
Klisovic, R.B.2
Hackanson, B.3
Liu, Z.4
Liu, S.5
Devine, H.6
Vukosavljevic, T.7
Huynh, L.8
Lozanski, G.9
Kefauver, C.10
Plass, C.11
Devine, S.M.12
Heerema, N.A.13
Murgo, A.14
Chan, K.K.15
Grever, M.R.16
Byrd, J.C.17
Marcucci, G.18
-
46
-
-
21244431605
-
Phase II study of low-dose decitabine in patients with chronic myelogenous leukemia resistant to imatinib mesylate
-
DOI 10.1200/JCO.2005.11.981
-
Issa JP, Gharibyan V, Cortes J, et al. Phase II study of low-dose decitabine in patients with chronic myelogenous leukemia resistant to imatinib mesylate. J Clin Oncol 2005;23:3948-3956 PubMed doi:10.1200/JCO.2005.11.981. (Pubitemid 46218698)
-
(2005)
Journal of Clinical Oncology
, vol.23
, Issue.17
, pp. 3948-3956
-
-
Issa, J.-P.F.1
Gharibyan, V.2
Cortes, J.3
Jelinek, J.4
Morris, G.5
Verstovsek, S.6
Talpaz, M.7
Garcia-Manero, G.8
Kantarjian, H.M.9
-
47
-
-
51649097598
-
A pilot pharmacokinetic study of oral azacitidine
-
PubMed doi:10.1038/leu.2008.145
-
Garcia-Manero G, Stoltz ML, Ward MR, Kantarjian H, Sharma S. A pilot pharmacokinetic study of oral azacitidine. Leukemia 2008;22:1680-1684 PubMed doi:10.1038/leu.2008.145.
-
(2008)
Leukemia
, vol.22
, pp. 1680-1684
-
-
Garcia-Manero, G.1
Stoltz, M.L.2
Ward, M.R.3
Kantarjian, H.4
Sharma, S.5
-
48
-
-
34447123203
-
Delivery of 5-aza-2′-deoxycytidine to cells using oligodeoxynucleotides
-
DOI 10.1158/0008-5472.CAN-07-0251
-
Yoo CB, Jeong S, Egger G, et al. Delivery of 5-aza-2″-deoxycytidine to cells using oligodeoxynucleotides. Cancer Res 2007;67:6400-8. PubMed doi:10.1158/0008-5472.CAN-07-0251. (Pubitemid 47037524)
-
(2007)
Cancer Research
, vol.67
, Issue.13
, pp. 6400-6408
-
-
Yoo, C.B.1
Jeong, S.2
Egger, G.3
Liang, G.4
Phiasivongsa, P.5
Tang, C.6
Redkar, S.7
Jones, P.A.8
-
49
-
-
60249094793
-
Mechanisms of resistance to 5-aza-2′-deoxycytidine in human cancer cell lines
-
Qin T, Jelinek J, Si J, Shu J, Issa JP. Mechanisms of resistance to 5-aza-2′-deoxycytidine in human cancer cell lines. Blood 2009;113:659-667
-
(2009)
Blood
, vol.113
, pp. 659-667
-
-
Qin, T.1
Jelinek, J.2
Si, J.3
Shu, J.4
Issa, J.P.5
-
50
-
-
0032948005
-
Synergy of demethylation and histone deacetylase inhibition in the re- Expression of genes silenced in cancer
-
DOI 10.1038/5047
-
Cameron EE, Bachman KE, Myohanen S, Herman JG, Baylin SB. Synergy of demethylation and histone deacetylase inhibition in the re- expression of genes silenced in cancer. Nat Genet 1999;21:103-107 PubMed doi:10.1038/5047. (Pubitemid 29036293)
-
(1999)
Nature Genetics
, vol.21
, Issue.1
, pp. 103-107
-
-
Cameron, E.E.1
Bachman, K.E.2
Myohanen, S.3
Herman, J.G.4
Baylin, S.B.5
-
51
-
-
67449145358
-
Rational combinations using HDAC inhibitors
-
Bots M, Johnstone RW. Rational combinations using HDAC inhibitors. Clin Cancer Res 2009;15:3970-3977
-
(2009)
Clin Cancer Res
, vol.15
, pp. 3970-3977
-
-
Bots, M.1
Johnstone, R.W.2
-
52
-
-
33847076849
-
Chromatin Modifications and Their Function
-
DOI 10.1016/j.cell.2007.02.005, PII S0092867407001845
-
Kouzarides T. Chromatin modifications and their function. Cell 2007;128:693-705. PubMed doi:10.1016/j.cell.2007.02.005. (Pubitemid 46273577)
-
(2007)
Cell
, vol.128
, Issue.4
, pp. 693-705
-
-
Kouzarides, T.1
-
53
-
-
44349131472
-
Gene silencing in cancer by histone H3 lysine 27 trimethylation independent of promoter DNA methylation
-
DOI 10.1038/ng.159, PII NG159
-
Kondo Y, Shen L, Cheng AS, et al. Gene silencing in cancer by histone H3 lysine 27 trimethylation independent of promoter DNA methylation. Nat Genet 2008;40:741-750 PubMed doi:10.1038/ng.159. (Pubitemid 351748874)
-
(2008)
Nature Genetics
, vol.40
, Issue.6
, pp. 741-750
-
-
Kondo, Y.1
Shen, L.2
Cheng, A.S.3
Ahmed, S.4
Boumber, Y.5
Charo, C.6
Yamochi, T.7
Urano, T.8
Furukawa, K.9
Kwabi-Addo, B.10
Gold, D.L.11
Sekido, Y.12
Huang, T.H.-M.13
Issa, J.-P.J.14
-
54
-
-
46449094276
-
Dissecting direct reprogramming through integrative genomic analysis
-
DOI 10.1038/nature07056, PII NATURE07056
-
Mikkelsen TS, Hanna J, Zhang X, et al. Dissecting direct reprogramming through integrative genomic analysis. Nature 2008;454:49-55. PubMed doi:10.1038/nature07056. (Pubitemid 351931978)
-
(2008)
Nature
, vol.454
, Issue.7200
, pp. 49-55
-
-
Mikkelsen, T.S.1
Hanna, J.2
Zhang, X.3
Ku, M.4
Wernig, M.5
Schorderet, P.6
Bernstein, B.E.7
Jaenisch, R.8
Lander, E.S.9
Meissner, A.10
-
55
-
-
58149174109
-
Phase I study of epigenetic modulation with 5-azacytidine and valproic acid in patientswith advanced cancers
-
PubMed doi:10.1158/1078-0432.CCR-08-1247
-
Braiteh F, Soriano AO, Garcia-Manero G, et al. Phase I study of epigenetic modulation with 5-azacytidine and valproic acid in patientswith advanced cancers. Clin Cancer Res 2008;14:6296-301. PubMed doi:10.1158/1078- 0432.CCR-08-1247.
-
(2008)
Clin Cancer Res
, vol.14
, pp. 6296-6301
-
-
Braiteh, F.1
Soriano, A.O.2
Garcia-Manero, G.3
-
56
-
-
29144473297
-
An epigenetic approach to the treatment of advanced MDS; the experience with the DNA demethylating agent 5-aza-2′-deoxycytidine (decitabine) in 177 patients
-
DOI 10.1007/s00277-005-0012-1
-
Wijermans PW, Lubbert M, Verhoef G, Klimek V, Bosly A. An epigenetic approach to the treatment of advanced MDS; the experience with the DNA demethylating agent 5-aza-2′-deoxycytidine (decitabine) in 177 patients. Ann Hematol 2005;84:9-17. PubMed doi:10.1007/s00277-005-0012-21 (Pubitemid 44419734)
-
(2005)
Annals of Hematology
, vol.84
, Issue.SUPPL. 13
, pp. 9-17
-
-
Wijermans, P.W.1
Lubbert, M.2
Verhoef, G.3
Klimek, V.4
Bosly, A.5
-
57
-
-
33646071894
-
Decitabine improves patient outcomes in myelodysplastic syndromes: Results of a phase III randomized study
-
PubMed doi:10.1002/cncr.21792
-
Kantarjian H, Issa JP, Rosenfeld CS, et al. Decitabine improves patient outcomes in myelodysplastic syndromes: results of a phase III randomized study. Cancer 2006;106:1794-1803 PubMed doi:10.1002/cncr.21792.
-
(2006)
Cancer
, vol.106
, pp. 1794-1803
-
-
Kantarjian, H.1
Issa, J.P.2
Rosenfeld, C.S.3
-
58
-
-
33750530675
-
Phase 1/2 study of the combination of 5-aza-2′-deoxycytidine with valproic acid in patients with leukemia
-
DOI 10.1182/blood-2006-03-009142
-
Garcia-Manero G, Kantarjian HM, Sanchez-Gonzalez B, et al. Phase 1/2 study of the combination of 5-aza-2′-deoxycytidine with valproic acid in patients with leukemia. Blood 2006;108:3271-9. PubMed doi:10.1182/blood-2006-03- 009142. (Pubitemid 44776863)
-
(2006)
Blood
, vol.108
, Issue.10
, pp. 3271-3279
-
-
Garcia-Manero, G.1
Kantarjian, H.M.2
Sanchez-Gonzalez, B.3
Yang, H.4
Rosner, G.5
Verstovsek, S.6
Rytting, M.7
Wierda, W.G.8
Ravandi, F.9
Koller, C.10
Xiao, L.11
Faderl, S.12
Estrov, Z.13
Cortes, J.14
O'Brien, S.15
Estey, E.16
Bueso-Ramos, C.17
Fiorentino, J.18
Jabbour, E.19
Issa, J.-P.20
more..
-
59
-
-
33748046812
-
Phase I trial of sequential low-dose 5-aza-2′-deoxycytidine plus high-dose intravenous bolus interleukin-2 in patients with melanoma or renal cell carcinoma
-
DOI 10.1158/1078-0432.CCR-06-0883
-
Gollob JA, Sciambi CJ, Peterson BL, et al. Phase I trial of sequential low-dose 5-aza-2′-deoxycytidine plus high-dose intravenous bolus interleukin-2 in patients with melanoma or renal cell carcinoma. Clin Cancer Res 2006;12:4619-27. PubMed doi:10.1158/1078-0432.CCR-06-0883. (Pubitemid 44297813)
-
(2006)
Clinical Cancer Research
, vol.12
, Issue.15
, pp. 4619-4627
-
-
Gollob, J.A.1
Sciambi, C.J.2
Peterson, B.L.3
Richmond, T.4
Thoreson, M.5
Moran, K.6
Dressman, H.K.7
Jelinek, J.8
Issa, J.-P.J.9
-
60
-
-
34548414620
-
Phase I and pharmacodynamic trial of the DNA methyltransferase inhibitor decitabine and carboplatin in solid tumors
-
DOI 10.1200/JCO.2007.10.8688
-
Appleton K, Mackay HJ, Judson I, et al. Phase I and pharmacodynamic trial of the DNA methyltransferase inhibitor decitabine and carboplatin in solid tumors. J Clin Oncol 2007;25:4603-4609 PubMed doi:10.1200/JCO.2007.10.8688. (Pubitemid 350035319)
-
(2007)
Journal of Clinical Oncology
, vol.25
, Issue.29
, pp. 4603-4609
-
-
Appleton, K.1
Mackay, H.J.2
Judson, I.3
Plumb, J.A.4
McCormick, C.5
Strathdee, G.6
Lee, C.7
Barrett, S.8
Reade, S.9
Jadayel, D.10
Tang, A.11
Bellenger, K.12
Mackay, L.13
Setanoians, A.14
Schatzlein, A.15
Twelves, C.16
Kaye, S.B.17
Brown, R.18
|