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Volumn 36, Issue 4, 2016, Pages 579-640

Short Anabolic Peptides for Bone Growth

Author keywords

anabolic peptides; bone formation; medicinal chemistry; osteoblast activity; osteoporosis

Indexed keywords

AMYLIN; ANABOLIC AGENT; APELIN; BONE MORPHOGENETIC PROTEIN; C PEPTIDE; COLLAGEN; COLLAGEN BINDING PROTEIN; DIANTHIN G; DIANTHIN H; ENDOTHELIN 1; GALANIN; GHRELIN; GROWTH HORMONE; HYPOPHYSIS ADENYLATE CYCLASE ACTIVATING POLYPEPTIDE; INTEGRIN; NATRIURETIC PEPTIDE TYPE C; OREXIN; OSTEOBLAST ACTIVATING PEPTIDE; OSTEOGENIC GROWTH PEPTIDE; OSTEOPONTIN; PANCREAS HORMONE; PARATHYROID HORMONE; PEPTIDE; PEPTIDE E; PEPTIDE FRAGMENT; PEPTIDE HORMONE; PREPTIN; RUSALATIDE; SUBSTANCE P; UNCLASSIFIED DRUG; VASOACTIVE INTESTINAL POLYPEPTIDE;

EID: 84974694608     PISSN: 01986325     EISSN: 10981128     Source Type: Journal    
DOI: 10.1002/med.21388     Document Type: Review
Times cited : (14)

References (402)
  • 2
    • 76649123607 scopus 로고    scopus 로고
    • Osteoporosis: impact on health and economics
    • Harvey N, Dennison E, Cooper C. Osteoporosis: impact on health and economics. Nat Rev Rheumatol 2010;6:99–105.
    • (2010) Nat Rev Rheumatol , vol.6 , pp. 99-105
    • Harvey, N.1    Dennison, E.2    Cooper, C.3
  • 3
    • 84880305680 scopus 로고    scopus 로고
    • Osteoporosis in the European Union: Medical management, epidemiology and economic burden. A report prepared in collaboration with the International Osteoporosis Foundation (IOF) and the European Federation of Pharmaceutical Industry Associations (EFPIA)
    • Hernlund E, Svedbom A, Ivergard M, Compston J, Cooper C, Stenmark J, McCloskey EV, Jonsson B, Kanis JA. Osteoporosis in the European Union: Medical management, epidemiology and economic burden. A report prepared in collaboration with the International Osteoporosis Foundation (IOF) and the European Federation of Pharmaceutical Industry Associations (EFPIA). Arch Osteoporos 2013;8(136):1–115.
    • (2013) Arch Osteoporos , vol.8 , Issue.136 , pp. 1-115
    • Hernlund, E.1    Svedbom, A.2    Ivergard, M.3    Compston, J.4    Cooper, C.5    Stenmark, J.6    McCloskey, E.V.7    Jonsson, B.8    Kanis, J.A.9
  • 4
    • 79953751008 scopus 로고    scopus 로고
    • Osteoporosis: Now and the future
    • Rachner TD, Khosla S, Hofbauer LC. Osteoporosis: Now and the future. Lancet 2011;377(9773):1276–1287.
    • (2011) Lancet , vol.377 , Issue.9773 , pp. 1276-1287
    • Rachner, T.D.1    Khosla, S.2    Hofbauer, L.C.3
  • 6
    • 84974684285 scopus 로고    scopus 로고
    • National Osteoporosis Foundation. http://www.nof.org/home.
  • 7
    • 53849088180 scopus 로고    scopus 로고
    • Anti-resorptive therapies for osteoporosis
    • Reid IR. Anti-resorptive therapies for osteoporosis. Semin Cell Dev Biol 2008;19(5):473–478.
    • (2008) Semin Cell Dev Biol , vol.19 , Issue.5 , pp. 473-478
    • Reid, I.R.1
  • 8
    • 80054893464 scopus 로고    scopus 로고
    • Parathyroid hormone analogues in the treatment of osteoporosis
    • Kraenzlin ME, Meier C. Parathyroid hormone analogues in the treatment of osteoporosis. Nat Rev Endocrinol 2011;7(11):647–656.
    • (2011) Nat Rev Endocrinol , vol.7 , Issue.11 , pp. 647-656
    • Kraenzlin, M.E.1    Meier, C.2
  • 9
    • 84931564509 scopus 로고    scopus 로고
    • Short-term and long–term effects of osteoporosis therapies
    • Reid IR. Short-term and long–term effects of osteoporosis therapies. Nat Rev Endocrinol 2015;11(7):418–428.
    • (2015) Nat Rev Endocrinol , vol.11 , Issue.7 , pp. 418-428
    • Reid, I.R.1
  • 10
    • 84929649834 scopus 로고    scopus 로고
    • Efficacy, effectiveness and side effects of medications used to prevent fractures
    • Reid IR. Efficacy, effectiveness and side effects of medications used to prevent fractures. J Intern Med 2015;277(6):690–706.
    • (2015) J Intern Med , vol.277 , Issue.6 , pp. 690-706
    • Reid, I.R.1
  • 13
    • 77954923592 scopus 로고    scopus 로고
    • Phospholipase C signaling via the parathyroid hormone (PTH)/PTH-related peptide receptor is essential for normal bone responses to PTH
    • Guo J, Liu M, Yang D, Bouxsein ML, Thomas CC, Schipani E, Bringhurst FR, Kronenberg HM. Phospholipase C signaling via the parathyroid hormone (PTH)/PTH-related peptide receptor is essential for normal bone responses to PTH. Endocrinology 2010;151(8):3502–3513.
    • (2010) Endocrinology , vol.151 , Issue.8 , pp. 3502-3513
    • Guo, J.1    Liu, M.2    Yang, D.3    Bouxsein, M.L.4    Thomas, C.C.5    Schipani, E.6    Bringhurst, F.R.7    Kronenberg, H.M.8
  • 14
    • 84856783815 scopus 로고    scopus 로고
    • Update on bone anabolics in osteoporosis treatment: Rationale, current status, and perspectives
    • Baron R, Hesse E. Update on bone anabolics in osteoporosis treatment: Rationale, current status, and perspectives. J Clin Endocrinol Metab 2012;97(2):311–325.
    • (2012) J Clin Endocrinol Metab , vol.97 , Issue.2 , pp. 311-325
    • Baron, R.1    Hesse, E.2
  • 15
    • 77952004118 scopus 로고    scopus 로고
    • Parathyroid hormone receptor directly interacts with dishevelled to regulate beta-Catenin signaling and osteoclastogenesis
    • Romero G, Sneddon WB, Yang Y, Wheeler D, Blair HC, Friedman PA. Parathyroid hormone receptor directly interacts with dishevelled to regulate beta-Catenin signaling and osteoclastogenesis. J Biol Chem 2010;285(19):14756–14763.
    • (2010) J Biol Chem , vol.285 , Issue.19 , pp. 14756-14763
    • Romero, G.1    Sneddon, W.B.2    Yang, Y.3    Wheeler, D.4    Blair, H.C.5    Friedman, P.A.6
  • 16
    • 84869453613 scopus 로고    scopus 로고
    • Safety of osteoanabolic therapy: A decade of experience
    • Cipriani C, Irani D, Bilezikian JP. Safety of osteoanabolic therapy: A decade of experience. J Bone Miner Res 2012;27(12):2419–2428.
    • (2012) J Bone Miner Res , vol.27 , Issue.12 , pp. 2419-2428
    • Cipriani, C.1    Irani, D.2    Bilezikian, J.P.3
  • 17
    • 0031024187 scopus 로고    scopus 로고
    • A randomized controlled trial to compare the efficacy of cyclical parathyroid hormone versus cyclical parathyroid hormone and sequential calcitonin to improve bone mass in postmenopausal women with osteoporosis
    • Hodsman AB, Fraher LJ, Watson PH, Ostbye T, Stitt LW, Adachi JD, Taves DH, Drost D. A randomized controlled trial to compare the efficacy of cyclical parathyroid hormone versus cyclical parathyroid hormone and sequential calcitonin to improve bone mass in postmenopausal women with osteoporosis. J Clin Endocrinol Metab 1997;82(2):620–628.
    • (1997) J Clin Endocrinol Metab , vol.82 , Issue.2 , pp. 620-628
    • Hodsman, A.B.1    Fraher, L.J.2    Watson, P.H.3    Ostbye, T.4    Stitt, L.W.5    Adachi, J.D.6    Taves, D.H.7    Drost, D.8
  • 18
    • 10744231292 scopus 로고    scopus 로고
    • Proteasomal degradation of Runx2 shortens parathyroid hormone-induced anti-apoptotic signaling in osteoblasts. A putative explanation for why intermittent administration is needed for bone anabolism
    • Bellido T, Ali AA, Plotkin LI, Fu Q, Gubrij I, Roberson PK, Weinstein RS, O'Brien CA, Manolagas SC, Jilka RL. Proteasomal degradation of Runx2 shortens parathyroid hormone-induced anti-apoptotic signaling in osteoblasts. A putative explanation for why intermittent administration is needed for bone anabolism. J Biol Chem 2003;278(50):50259–50272.
    • (2003) J Biol Chem , vol.278 , Issue.50 , pp. 50259-50272
    • Bellido, T.1    Ali, A.A.2    Plotkin, L.I.3    Fu, Q.4    Gubrij, I.5    Roberson, P.K.6    Weinstein, R.S.7    O'Brien, C.A.8    Manolagas, S.C.9    Jilka, R.L.10
  • 21
    • 0345305666 scopus 로고    scopus 로고
    • Efficacy and safety of human parathyroid hormone-(1–84) in increasing bone mineral density in postmenopausal osteoporosis
    • Hodsman AB, Hanley DA, Ettinger MP, Bolognese MA, Fox J, Metcalfe AJ, Lindsay R. Efficacy and safety of human parathyroid hormone-(1–84) in increasing bone mineral density in postmenopausal osteoporosis. J Clin Endocrinol Metab 2003;88(11):5212–5220.
    • (2003) J Clin Endocrinol Metab , vol.88 , Issue.11 , pp. 5212-5220
    • Hodsman, A.B.1    Hanley, D.A.2    Ettinger, M.P.3    Bolognese, M.A.4    Fox, J.5    Metcalfe, A.J.6    Lindsay, R.7
  • 22
    • 57749189593 scopus 로고    scopus 로고
    • Teriparatide: A review of its use in osteoporosis
    • Blick SK, Dhillon S, Keam SJ. Teriparatide: A review of its use in osteoporosis. Drugs 2008;68(18):2709–2737.
    • (2008) Drugs , vol.68 , Issue.18 , pp. 2709-2737
    • Blick, S.K.1    Dhillon, S.2    Keam, S.J.3
  • 24
    • 77955846573 scopus 로고    scopus 로고
    • Effects of teriparatide on bone mineral density and bone turnover markers in Japanese subjects with osteoporosis at high risk of fracture in a 24-month clinical study: 12-Month, randomized, placebo-controlled, double-blind and 12-month open-label phases
    • Miyauchi A, Matsumoto T, Sugimoto T, Tsujimoto M, Warner MR, Nakamura T. Effects of teriparatide on bone mineral density and bone turnover markers in Japanese subjects with osteoporosis at high risk of fracture in a 24-month clinical study: 12-Month, randomized, placebo-controlled, double-blind and 12-month open-label phases. Bone 2010;47(3):493–502.
    • (2010) Bone , vol.47 , Issue.3 , pp. 493-502
    • Miyauchi, A.1    Matsumoto, T.2    Sugimoto, T.3    Tsujimoto, M.4    Warner, M.R.5    Nakamura, T.6
  • 25
    • 0037406825 scopus 로고    scopus 로고
    • The anabolic effects of parathyroid hormone therapy
    • Rubin MR, Bilezikian JP. The anabolic effects of parathyroid hormone therapy. Clin Geriatr Med 2003;19(2):415–432.
    • (2003) Clin Geriatr Med , vol.19 , Issue.2 , pp. 415-432
    • Rubin, M.R.1    Bilezikian, J.P.2
  • 26
    • 84866148169 scopus 로고    scopus 로고
    • Randomized Teriparatide [human parathyroid hormone (PTH) 1-34] Once-Weekly Efficacy Research (TOWER) trial for examining the reduction in new vertebral fractures in subjects with primary osteoporosis and high fracture risk
    • Nakamura T, Sugimoto T, Nakano T, Kishimoto H, Ito M, Fukunaga M, Hagino H, Sone T, Yoshikawa H, Nishizawa Y, Fujita T, Shiraki M. Randomized Teriparatide [human parathyroid hormone (PTH) 1-34] Once-Weekly Efficacy Research (TOWER) trial for examining the reduction in new vertebral fractures in subjects with primary osteoporosis and high fracture risk. J Clin Endocrinol Metab 2012;97(9):3097–3106.
    • (2012) J Clin Endocrinol Metab , vol.97 , Issue.9 , pp. 3097-3106
    • Nakamura, T.1    Sugimoto, T.2    Nakano, T.3    Kishimoto, H.4    Ito, M.5    Fukunaga, M.6    Hagino, H.7    Sone, T.8    Yoshikawa, H.9    Nishizawa, Y.10    Fujita, T.11    Shiraki, M.12
  • 27
    • 34248577022 scopus 로고    scopus 로고
    • Molecular and cellular mechanisms of the anabolic effect of intermittent PTH
    • Jilka RL. Molecular and cellular mechanisms of the anabolic effect of intermittent PTH. Bone 2007;40(6):1434–1446.
    • (2007) Bone , vol.40 , Issue.6 , pp. 1434-1446
    • Jilka, R.L.1
  • 28
    • 77951624097 scopus 로고    scopus 로고
    • Update in new anabolic therapies for osteoporosis
    • Canalis E. Update in new anabolic therapies for osteoporosis. J Clin Endocrinol Metab 2010;95(4):1496–1504.
    • (2010) J Clin Endocrinol Metab , vol.95 , Issue.4 , pp. 1496-1504
    • Canalis, E.1
  • 29
    • 84916891469 scopus 로고    scopus 로고
    • Single and combined use of human parathyroid hormone (PTH) (1-34) on areal bone mineral density (aBMD) in postmenopausal women with osteoporosis: Evidence based on 9 RCTs
    • Song J, Jing Z, Chang F, Li L, Su Y. Single and combined use of human parathyroid hormone (PTH) (1-34) on areal bone mineral density (aBMD) in postmenopausal women with osteoporosis: Evidence based on 9 RCTs. Med Sci Monit 2014;20:2624–2632.
    • (2014) Med Sci Monit , vol.20 , pp. 2624-2632
    • Song, J.1    Jing, Z.2    Chang, F.3    Li, L.4    Su, Y.5
  • 32
    • 84940733806 scopus 로고    scopus 로고
    • Healing of bisphosphonate-associated atypical femoral fractures in patients with osteoporosis: A comparison between treatment with and without teriparatide
    • Miyakoshi N, Aizawa T, Sasaki S, Ando S, Maekawa S, Aonuma H, Tsuchie H, Sasaki H, Kasukawa Y, Shimada Y. Healing of bisphosphonate-associated atypical femoral fractures in patients with osteoporosis: A comparison between treatment with and without teriparatide. J Bone Miner Metab 2015;33(5):553–559.
    • (2015) J Bone Miner Metab , vol.33 , Issue.5 , pp. 553-559
    • Miyakoshi, N.1    Aizawa, T.2    Sasaki, S.3    Ando, S.4    Maekawa, S.5    Aonuma, H.6    Tsuchie, H.7    Sasaki, H.8    Kasukawa, Y.9    Shimada, Y.10
  • 33
    • 84905246905 scopus 로고    scopus 로고
    • Literature review: The effects of teriparatide therapy at the hip in patients with osteoporosis
    • Eriksen EF, Keaveny TM, Gallagher ER, Krege JH. Literature review: The effects of teriparatide therapy at the hip in patients with osteoporosis. Bone 2014;67:246–256.
    • (2014) Bone , vol.67 , pp. 246-256
    • Eriksen, E.F.1    Keaveny, T.M.2    Gallagher, E.R.3    Krege, J.H.4
  • 34
    • 3242887547 scopus 로고    scopus 로고
    • Bone neoplasms in F344 rats given teriparatide [rhPTH(1-34)] are dependent on duration of treatment and dose
    • Vahle JL, Long GG, Sandusky G, Westmore M, Ma YL, Sato M. Bone neoplasms in F344 rats given teriparatide [rhPTH(1-34)] are dependent on duration of treatment and dose. Toxicol Pathol 2004;32(4):426–438.
    • (2004) Toxicol Pathol , vol.32 , Issue.4 , pp. 426-438
    • Vahle, J.L.1    Long, G.G.2    Sandusky, G.3    Westmore, M.4    Ma, Y.L.5    Sato, M.6
  • 35
    • 44849091923 scopus 로고    scopus 로고
    • Safety of parathyroid hormone for the treatment of osteoporosis
    • Miller PD. Safety of parathyroid hormone for the treatment of osteoporosis. Curr Osteoporos Rep 2008;6(1):12–16.
    • (2008) Curr Osteoporos Rep , vol.6 , Issue.1 , pp. 12-16
    • Miller, P.D.1
  • 36
    • 84925490554 scopus 로고    scopus 로고
    • Teriparatide treatment patterns in osteoporosis and subsequent fracture events: A US claims analysis
    • Bonafede MM, Shi N, Bower AG, Barron RL, Grauer A, Chandler DB. Teriparatide treatment patterns in osteoporosis and subsequent fracture events: A US claims analysis. Osteoporos Int 2015;26(3):1203–1212.
    • (2015) Osteoporos Int , vol.26 , Issue.3 , pp. 1203-1212
    • Bonafede, M.M.1    Shi, N.2    Bower, A.G.3    Barron, R.L.4    Grauer, A.5    Chandler, D.B.6
  • 37
    • 84941282411 scopus 로고    scopus 로고
    • Early effects of single and low-frequency repeated administration of teriparatide, hPTH(1-34), on bone formation and resorption in ovariectomized rats
    • Isogai Y, Takao-Kawabata R, Takakura A, Sugimoto E, Nakazono O, Ikegaki I, Kuriyama H, Ishizuya T. Early effects of single and low-frequency repeated administration of teriparatide, hPTH(1-34), on bone formation and resorption in ovariectomized rats. Calcif Tissue Int 2015;97(4):412–420.
    • (2015) Calcif Tissue Int , vol.97 , Issue.4 , pp. 412-420
    • Isogai, Y.1    Takao-Kawabata, R.2    Takakura, A.3    Sugimoto, E.4    Nakazono, O.5    Ikegaki, I.6    Kuriyama, H.7    Ishizuya, T.8
  • 39
    • 84866017861 scopus 로고    scopus 로고
    • A single injection of the anabolic bone agent, parathyroid hormone-collagen binding domain (PTH-CBD), results in sustained increases in bone mineral density for up to 12 months in normal female mice
    • Ponnapakkam T, Katikaneni R, Suda H, Miyata S, Matsushita O, Sakon J, Gensure RC. A single injection of the anabolic bone agent, parathyroid hormone-collagen binding domain (PTH-CBD), results in sustained increases in bone mineral density for up to 12 months in normal female mice. Calcif Tissue Int 2012;91(3):196–203.
    • (2012) Calcif Tissue Int , vol.91 , Issue.3 , pp. 196-203
    • Ponnapakkam, T.1    Katikaneni, R.2    Suda, H.3    Miyata, S.4    Matsushita, O.5    Sakon, J.6    Gensure, R.C.7
  • 40
    • 84858054312 scopus 로고    scopus 로고
    • The single dose pharmacokinetic profile of a novel oral human parathyroid hormone formulation in healthy postmenopausal women
    • Hammerle SP, Mindeholm L, Launonen A, Kiese B, Loeffler R, Harfst E, Azria M, Arnold M, John MR. The single dose pharmacokinetic profile of a novel oral human parathyroid hormone formulation in healthy postmenopausal women. Bone 2012;50(4):965–973.
    • (2012) Bone , vol.50 , Issue.4 , pp. 965-973
    • Hammerle, S.P.1    Mindeholm, L.2    Launonen, A.3    Kiese, B.4    Loeffler, R.5    Harfst, E.6    Azria, M.7    Arnold, M.8    John, M.R.9
  • 41
    • 78651225870 scopus 로고    scopus 로고
    • Parathyroid hormone (1-34)-coated microneedle patch system: Clinical pharmacokinetics and pharmacodynamics for treatment of osteoporosis
    • Daddona PE, Matriano JA, Mandema J, Maa YF. Parathyroid hormone (1-34)-coated microneedle patch system: Clinical pharmacokinetics and pharmacodynamics for treatment of osteoporosis. Pharm Res 2011;28(1):159–165.
    • (2011) Pharm Res , vol.28 , Issue.1 , pp. 159-165
    • Daddona, P.E.1    Matriano, J.A.2    Mandema, J.3    Maa, Y.F.4
  • 43
    • 33748636445 scopus 로고    scopus 로고
    • Daily nasal spray of hPTH(1-34) for 3 months increases bone mass in osteoporotic subjects: A pilot study
    • Matsumoto T, Shiraki M, Hagino H, Iinuma H, Nakamura T. Daily nasal spray of hPTH(1-34) for 3 months increases bone mass in osteoporotic subjects: A pilot study. Osteoporos Int 2006;17(10):1532–1538.
    • (2006) Osteoporos Int , vol.17 , Issue.10 , pp. 1532-1538
    • Matsumoto, T.1    Shiraki, M.2    Hagino, H.3    Iinuma, H.4    Nakamura, T.5
  • 45
    • 0030031878 scopus 로고    scopus 로고
    • Stimulation of the growth of femoral trabecular bone in ovariectomized rats by the novel parathyroid hormone fragment, hPTH-(1-31)NH2 (ostabolin)
    • Whitfield JF, Morley P, Willick GE, Ross V, Barbier JR, Isaacs RJ, Ohannessian-Barry L. Stimulation of the growth of femoral trabecular bone in ovariectomized rats by the novel parathyroid hormone fragment, hPTH-(1-31)NH2 (ostabolin). Calcif Tissue Int 1996;58(2):81–87.
    • (1996) Calcif Tissue Int , vol.58 , Issue.2 , pp. 81-87
    • Whitfield, J.F.1    Morley, P.2    Willick, G.E.3    Ross, V.4    Barbier, J.R.5    Isaacs, R.J.6    Ohannessian-Barry, L.7
  • 46
    • 0030884830 scopus 로고    scopus 로고
    • Comparison of the abilities of human parathyroid hormone(1-31)NH2 and human parathyroid hormone-related protein(1-31)NH2 to stimulate femoral trabecular bone growth in ovariectomized rats
    • Whitfield JF, Morley P, Willick GE, Ross V, Langille R, MacLean S, Barbier J, Isaacs RJ, Ohannessian-Barry L. Comparison of the abilities of human parathyroid hormone(1-31)NH2 and human parathyroid hormone-related protein(1-31)NH2 to stimulate femoral trabecular bone growth in ovariectomized rats. Calcif Tissue Int 1997;61(4):322–326.
    • (1997) Calcif Tissue Int , vol.61 , Issue.4 , pp. 322-326
    • Whitfield, J.F.1    Morley, P.2    Willick, G.E.3    Ross, V.4    Langille, R.5    MacLean, S.6    Barbier, J.7    Isaacs, R.J.8    Ohannessian-Barry, L.9
  • 48
    • 0030740994 scopus 로고    scopus 로고
    • Cyclization by a specific lactam increases the ability of human parathyroid hormone (hPTH)-(1-31)NH2 to stimulate bone growth in ovariectomized rats
    • Whitfield JF, Morley P, Willick G, Langille R, Ross V, MacLean S, Barbier JR. Cyclization by a specific lactam increases the ability of human parathyroid hormone (hPTH)-(1-31)NH2 to stimulate bone growth in ovariectomized rats. J Bone Miner Res 1997;12(8):1246–1252.
    • (1997) J Bone Miner Res , vol.12 , Issue.8 , pp. 1246-1252
    • Whitfield, J.F.1    Morley, P.2    Willick, G.3    Langille, R.4    Ross, V.5    MacLean, S.6    Barbier, J.R.7
  • 49
    • 43149118638 scopus 로고    scopus 로고
    • Ostabolin-C increases lumbar spine and hip BMD after 1 year of therapy: Results of a phase II clinical trial
    • Hodsman A, Bone H, Gallagher C. Ostabolin-C increases lumbar spine and hip BMD after 1 year of therapy: Results of a phase II clinical trial. J Bone Miner Res 2007;22(Suppl 1):S38.
    • (2007) J Bone Miner Res , vol.22 , pp. S38
    • Hodsman, A.1    Bone, H.2    Gallagher, C.3
  • 50
    • 39149086895 scopus 로고    scopus 로고
    • Pulmonary delivery of the parathyroid hormone analogue ostabolin-CTM stimulates markers of bone formation in postmenopausal women
    • Morley P, Bishop J, andersen R. Pulmonary delivery of the parathyroid hormone analogue ostabolin-CTM stimulates markers of bone formation in postmenopausal women. J Bone Miner Res 2007;22(Suppl 1):S127.
    • (2007) J Bone Miner Res , vol.22 , pp. S127
    • Morley, P.1    Bishop, J.2    andersen, R.3
  • 52
    • 0038687536 scopus 로고    scopus 로고
    • Developmental regulation of the growth plate
    • Kronenberg HM. Developmental regulation of the growth plate. Nature 2003;423(6937):332–336.
    • (2003) Nature , vol.423 , Issue.6937 , pp. 332-336
    • Kronenberg, H.M.1
  • 53
    • 0037323386 scopus 로고    scopus 로고
    • Short-term, high-dose parathyroid hormone-related protein as a skeletal anabolic agent for the treatment of postmenopausal osteoporosis
    • Horwitz MJ, Tedesco MB, Gundberg C, Garcia-Ocana A, Stewart AF. Short-term, high-dose parathyroid hormone-related protein as a skeletal anabolic agent for the treatment of postmenopausal osteoporosis. J Clin Endocrinol Metab 2003;88(2):569–575.
    • (2003) J Clin Endocrinol Metab , vol.88 , Issue.2 , pp. 569-575
    • Horwitz, M.J.1    Tedesco, M.B.2    Gundberg, C.3    Garcia-Ocana, A.4    Stewart, A.F.5
  • 55
    • 85043222871 scopus 로고    scopus 로고
    • Pharmacokinetics and pharmacodynamic of subcutaneously (SC) administered doses of BA058, a bone mass density restoring agent in healthy postmenopausal women
    • (abstract);
    • Obaidi M, Chavira R, Reinbolt L, Offman E, McKay E, O'Dea L. Pharmacokinetics and pharmacodynamic of subcutaneously (SC) administered doses of BA058, a bone mass density restoring agent in healthy postmenopausal women. AAPS 2010 (abstract);W5385.
    • (2010) AAPS , pp. W5385
    • Obaidi, M.1    Chavira, R.2    Reinbolt, L.3    Offman, E.4    McKay, E.5    O'Dea, L.6
  • 56
    • 84922540418 scopus 로고    scopus 로고
    • Long term effect of BA058, a novel human PTHrP analog, Restores bone mass in the aged osteopenic ovariectomized cynomolgus monkeys
    • ((abstract)
    • Doyle N, Varela A, Smith S, Guldberg R, Hattersley G. Long term effect of BA058, a novel human PTHrP analog, Restores bone mass in the aged osteopenic ovariectomized cynomolgus monkeys. J Bone Miner Res 2013;28(Suppl 1)(abstract).
    • (2013) J Bone Miner Res , vol.28
    • Doyle, N.1    Varela, A.2    Smith, S.3    Guldberg, R.4    Hattersley, G.5
  • 57
    • 84922550260 scopus 로고    scopus 로고
    • BA058, a novel human PTHrP analog, restores bone density and increases bone strength at the spine and femur in osteopenic rats
    • (abstract)
    • Hattersley G, Lesage E, Varela A, Mith S. BA058, a novel human PTHrP analog, restores bone density and increases bone strength at the spine and femur in osteopenic rats. Endocr Rev 2013;34(abstract).
    • (2013) Endocr Rev , vol.34
    • Hattersley, G.1    Lesage, E.2    Varela, A.3    Mith, S.4
  • 58
    • 84922553490 scopus 로고    scopus 로고
    • Effects of abaloparatide, a human parathyroid hormone-related peptide analog, on bone mineral density in postmenopausal women with osteoporosis
    • Leder BZ, O'Dea LS, Zanchetta JR, Kumar P, Banks K, McKay K, Lyttle CR, Hattersley G. Effects of abaloparatide, a human parathyroid hormone-related peptide analog, on bone mineral density in postmenopausal women with osteoporosis. J Clin Endocrinol Metab 2015;100(2):697–706.
    • (2015) J Clin Endocrinol Metab , vol.100 , Issue.2 , pp. 697-706
    • Leder, B.Z.1    O'Dea, L.S.2    Zanchetta, J.R.3    Kumar, P.4    Banks, K.5    McKay, K.6    Lyttle, C.R.7    Hattersley, G.8
  • 59
    • 84974730102 scopus 로고    scopus 로고
    • Radius Health. http://ir.radiuspharm.com/releasedetail.cfm?ReleaseID=9362012015.
  • 60
    • 0037102590 scopus 로고    scopus 로고
    • Use of recombinant human bone morphogenetic protein-2 in spinal fusion applications
    • McKay B, Sandhu HS. Use of recombinant human bone morphogenetic protein-2 in spinal fusion applications. Spine 2002;27(16S):S66–S85.
    • (2002) Spine , vol.27 , Issue.16S , pp. S66-S85
    • McKay, B.1    Sandhu, H.S.2
  • 61
    • 33745713060 scopus 로고    scopus 로고
    • Recombinant human BMP-2 and allograft compared with autogenous bone graft for reconstruction of diaphyseal tibial fractures with cortical defects
    • A randomized, controlled trial
    • Jones AL, Bucholz RW, Bosse MJ, Mirza SK, Lyon TR, Webb LX, Pollak AN, Golden JD, Valentin-Opran A. Recombinant human BMP-2 and allograft compared with autogenous bone graft for reconstruction of diaphyseal tibial fractures with cortical defects. A randomized, controlled trial. J Bone Joint Surg Am 2006;88(7):1431–1441.
    • (2006) J Bone Joint Surg Am , vol.88 , Issue.7 , pp. 1431-1441
    • Jones, A.L.1    Bucholz, R.W.2    Bosse, M.J.3    Mirza, S.K.4    Lyon, T.R.5    Webb, L.X.6    Pollak, A.N.7    Golden, J.D.8    Valentin-Opran, A.9
  • 62
    • 36448936383 scopus 로고    scopus 로고
    • TGFbeta-SMAD signal transduction: Molecular specificity and functional flexibility
    • Schmierer B, Hill CS. TGFbeta-SMAD signal transduction: Molecular specificity and functional flexibility. Nat Rev Mol Cell Biol 2007;8(12):970–982.
    • (2007) Nat Rev Mol Cell Biol , vol.8 , Issue.12 , pp. 970-982
    • Schmierer, B.1    Hill, C.S.2
  • 63
    • 0032453010 scopus 로고    scopus 로고
    • Effects of BMP-2 on osteoblastic cells and on skeletal growth and bone formation in unloaded rats
    • Zerath E, Holy X, Noel B, Malouvier A, Hott M, Marie PJ. Effects of BMP-2 on osteoblastic cells and on skeletal growth and bone formation in unloaded rats. Growth Horm IGF Res 1998;8(2):141–149.
    • (1998) Growth Horm IGF Res , vol.8 , Issue.2 , pp. 141-149
    • Zerath, E.1    Holy, X.2    Noel, B.3    Malouvier, A.4    Hott, M.5    Marie, P.J.6
  • 64
    • 16244411961 scopus 로고    scopus 로고
    • The ABCs of BMPs
    • Boden SD. The ABCs of BMPs. Orthop Nurs 2005;24(1):49–52.
    • (2005) Orthop Nurs , vol.24 , Issue.1 , pp. 49-52
    • Boden, S.D.1
  • 65
    • 2442638878 scopus 로고    scopus 로고
    • The use of recombinant human bone morphogenetic protein-2 (rhBMP-2) in orthopaedic applications
    • Khan SN, Lane JM. The use of recombinant human bone morphogenetic protein-2 (rhBMP-2) in orthopaedic applications. Expert Opin Biol Ther 2004;4(5):741–748.
    • (2004) Expert Opin Biol Ther , vol.4 , Issue.5 , pp. 741-748
    • Khan, S.N.1    Lane, J.M.2
  • 66
    • 0034029862 scopus 로고    scopus 로고
    • Alginate hydrogel linked with synthetic oligopeptide derived from BMP-2 allows ectopic osteoinduction in vivo
    • Suzuki Y, Tanihara M, Suzuki K, Saitou A, Sufan W, Nishimura Y. Alginate hydrogel linked with synthetic oligopeptide derived from BMP-2 allows ectopic osteoinduction in vivo. J Biomed Mater Res 2000;50(3):405–409.
    • (2000) J Biomed Mater Res , vol.50 , Issue.3 , pp. 405-409
    • Suzuki, Y.1    Tanihara, M.2    Suzuki, K.3    Saitou, A.4    Sufan, W.5    Nishimura, Y.6
  • 67
    • 84974675133 scopus 로고    scopus 로고
    • Activation of osteo-progenitor cells by a novel synthetic peptide derived from the bone morphogenetic protein-2 knuckle epitope
    • Saito A, Suzuki Y, Ogata S, Ohtsuki C, Tanihara M. Activation of osteo-progenitor cells by a novel synthetic peptide derived from the bone morphogenetic protein-2 knuckle epitope. Biochim Biophys Acta 2003;23:1–2.
    • (2003) Biochim Biophys Acta , vol.23 , pp. 1-2
    • Saito, A.1    Suzuki, Y.2    Ogata, S.3    Ohtsuki, C.4    Tanihara, M.5
  • 68
    • 10344249901 scopus 로고    scopus 로고
    • Accelerated bone repair with the use of a synthetic BMP-2-derived peptide and bone-marrow stromal cells
    • Saito A, Suzuki Y, Ogata S, Ohtsuki C, Tanihara M. Accelerated bone repair with the use of a synthetic BMP-2-derived peptide and bone-marrow stromal cells. J Biomed Mater Res 2005;72(1):77–82.
    • (2005) J Biomed Mater Res , vol.72 , Issue.1 , pp. 77-82
    • Saito, A.1    Suzuki, Y.2    Ogata, S.3    Ohtsuki, C.4    Tanihara, M.5
  • 69
    • 3042727188 scopus 로고    scopus 로고
    • Prolonged ectopic calcification induced by BMP-2-derived synthetic peptide
    • Saito A, Suzuki Y, Ogata S, Ohtsuki C, Tanihara M. Prolonged ectopic calcification induced by BMP-2-derived synthetic peptide. J Biomed Mater Res 2004;70(1):115–121.
    • (2004) J Biomed Mater Res , vol.70 , Issue.1 , pp. 115-121
    • Saito, A.1    Suzuki, Y.2    Ogata, S.3    Ohtsuki, C.4    Tanihara, M.5
  • 70
    • 34248551399 scopus 로고    scopus 로고
    • Experimental research on ectopic osteogenesis of BMP2-derived peptide P24 combined with PLGA copolymers
    • Duan Z, Zheng Q, Guo X, Yuan Q, Chen S. Experimental research on ectopic osteogenesis of BMP2-derived peptide P24 combined with PLGA copolymers. J Huazhong Univ Sci Technol 2007;27(2):179–182.
    • (2007) J Huazhong Univ Sci Technol , vol.27 , Issue.2 , pp. 179-182
    • Duan, Z.1    Zheng, Q.2    Guo, X.3    Yuan, Q.4    Chen, S.5
  • 71
    • 33847016490 scopus 로고    scopus 로고
    • Bioinspired growth of hydroxyapatite nanocrystals on PLGA-(PEG-ASP)n scaffolds modified with oligopeptide derived from BMP-2
    • Yuan Q, Guo X, Zheng Q, Zhao M, Pan Z, Chen S, Quan D. Bioinspired growth of hydroxyapatite nanocrystals on PLGA-(PEG-ASP)n scaffolds modified with oligopeptide derived from BMP-2. Key Eng Mater 2007;334-335:1261–1264.
    • (2007) Key Eng Mater , vol.334-335 , pp. 1261-1264
    • Yuan, Q.1    Guo, X.2    Zheng, Q.3    Zhao, M.4    Pan, Z.5    Chen, S.6    Quan, D.7
  • 72
    • 58149529591 scopus 로고    scopus 로고
    • Preparation and ectopic osteogenesis in vivo of scaffold based on mineralized recombinant human-like collagen loaded with synthetic BMP-2-derived peptide
    • Wu B, Zheng Q, Guo X, Wu Y, Wang Y, Cui F. Preparation and ectopic osteogenesis in vivo of scaffold based on mineralized recombinant human-like collagen loaded with synthetic BMP-2-derived peptide. Biomed Mater 2008;3(4):044111.
    • (2008) Biomed Mater , vol.3 , Issue.4 , pp. 044111
    • Wu, B.1    Zheng, Q.2    Guo, X.3    Wu, Y.4    Wang, Y.5    Cui, F.6
  • 73
    • 0038332706 scopus 로고    scopus 로고
    • Bone formation on two-dimensional poly(DL-lactide-co-glycolide) (PLGA) films and three-dimensional PLGA tissue engineering scaffolds in vitro
    • Karp JM, Shoichet MS, Davies JE. Bone formation on two-dimensional poly(DL-lactide-co-glycolide) (PLGA) films and three-dimensional PLGA tissue engineering scaffolds in vitro. J Biomed Mater Res A 2003;64(2):388–396.
    • (2003) J Biomed Mater Res A , vol.64 , Issue.2 , pp. 388-396
    • Karp, J.M.1    Shoichet, M.S.2    Davies, J.E.3
  • 74
    • 77952602328 scopus 로고    scopus 로고
    • Bone induction by biomimetic PLGA-(PEG-ASP)n copolymer loaded with a novel synthetic BMP-2-related peptide in vitro and in vivo
    • Lin ZY, Duan ZX, Guo XD, Li JF, Lu HW, Zheng QX, Quan DP, Yang SH. Bone induction by biomimetic PLGA-(PEG-ASP)n copolymer loaded with a novel synthetic BMP-2-related peptide in vitro and in vivo. J Control Release 2010;144(2):190–195.
    • (2010) J Control Release , vol.144 , Issue.2 , pp. 190-195
    • Lin, Z.Y.1    Duan, Z.X.2    Guo, X.D.3    Li, J.F.4    Lu, H.W.5    Zheng, Q.X.6    Quan, D.P.7    Yang, S.H.8
  • 75
    • 80053216243 scopus 로고    scopus 로고
    • Repair of rat cranial bone defects with nHAC/PLLA and BMP-2-related peptide or rhBMP-2
    • Li J, Hong J, Zheng Q, Guo X, Lan S, Cui F, Pan H, Zou Z, Chen C. Repair of rat cranial bone defects with nHAC/PLLA and BMP-2-related peptide or rhBMP-2. J Orthop Res 2011;29(11):1745–1752.
    • (2011) J Orthop Res , vol.29 , Issue.11 , pp. 1745-1752
    • Li, J.1    Hong, J.2    Zheng, Q.3    Guo, X.4    Lan, S.5    Cui, F.6    Pan, H.7    Zou, Z.8    Chen, C.9
  • 76
    • 77956255227 scopus 로고    scopus 로고
    • The effect of bone morphogenetic protein-2, bone morphogenetic protein-7, parathyroid hormone, and platelet-derived growth factor on the proliferation and osteogenic differentiation of mesenchymal stem cells derived from osteoporotic bone
    • Pountos I, Georgouli T, Henshaw K, Bird H, Jones E, Giannoudis PV. The effect of bone morphogenetic protein-2, bone morphogenetic protein-7, parathyroid hormone, and platelet-derived growth factor on the proliferation and osteogenic differentiation of mesenchymal stem cells derived from osteoporotic bone. J Orthop Trauma 2010;24(9):552–556.
    • (2010) J Orthop Trauma , vol.24 , Issue.9 , pp. 552-556
    • Pountos, I.1    Georgouli, T.2    Henshaw, K.3    Bird, H.4    Jones, E.5    Giannoudis, P.V.6
  • 78
    • 70349149485 scopus 로고    scopus 로고
    • Increased osteoblast functions in the presence of BMP-7 short peptides for nanostructured biomaterial applications
    • Chen Y, Webster TJ. Increased osteoblast functions in the presence of BMP-7 short peptides for nanostructured biomaterial applications. J Biomed Mater Res 2009;91(1):296–304.
    • (2009) J Biomed Mater Res , vol.91 , Issue.1 , pp. 296-304
    • Chen, Y.1    Webster, T.J.2
  • 80
    • 33847382801 scopus 로고    scopus 로고
    • Differentiation of preosteoblasts using a delivery system with BMPs and bioactive glass microspheres
    • Bergeron E, Marquis ME, Chrétien I, Faucheux N. Differentiation of preosteoblasts using a delivery system with BMPs and bioactive glass microspheres. J Mater Sci Mater Med 2007;18(2):255–263.
    • (2007) J Mater Sci Mater Med , vol.18 , Issue.2 , pp. 255-263
    • Bergeron, E.1    Marquis, M.E.2    Chrétien, I.3    Faucheux, N.4
  • 81
    • 72649096994 scopus 로고    scopus 로고
    • Murine preosteoblast differentiation induced by a peptide derived from bone morphogenetic proteins-9
    • Bergeron E, Senta H, Mailloux A, Park H, Lord E, Faucheux N. Murine preosteoblast differentiation induced by a peptide derived from bone morphogenetic proteins-9. Tissue Eng 2009;15(11):3341–3349.
    • (2009) Tissue Eng , vol.15 , Issue.11 , pp. 3341-3349
    • Bergeron, E.1    Senta, H.2    Mailloux, A.3    Park, H.4    Lord, E.5    Faucheux, N.6
  • 82
    • 84856281852 scopus 로고    scopus 로고
    • The evaluation of ectopic bone formation induced by delivery systems for bone morphogenetic protein-9 or its derived peptide
    • Bergeron E, Leblanc E, Drevelle O, Giguere R, Beauvais S, Grenier G, Faucheux N. The evaluation of ectopic bone formation induced by delivery systems for bone morphogenetic protein-9 or its derived peptide. Tissue Eng 2012;18(3-4):342–352.
    • (2012) Tissue Eng , vol.18 , Issue.3-4 , pp. 342-352
    • Bergeron, E.1    Leblanc, E.2    Drevelle, O.3    Giguere, R.4    Beauvais, S.5    Grenier, G.6    Faucheux, N.7
  • 83
    • 77955281661 scopus 로고    scopus 로고
    • The identification of a heparin binding domain peptide from bone morphogenetic protein-4 and its role on osteogenesis
    • Choi YJ, Lee JY, Park JH, Park JB, Suh JS, Choi YS, Lee SJ, Chung CP, Park YJ. The identification of a heparin binding domain peptide from bone morphogenetic protein-4 and its role on osteogenesis. Biomaterials 2010;31(28):7226–7238.
    • (2010) Biomaterials , vol.31 , Issue.28 , pp. 7226-7238
    • Choi, Y.J.1    Lee, J.Y.2    Park, J.H.3    Park, J.B.4    Suh, J.S.5    Choi, Y.S.6    Lee, S.J.7    Chung, C.P.8    Park, Y.J.9
  • 84
    • 0030727947 scopus 로고    scopus 로고
    • The action of GH/IGF-I/IGFBP in osteoblasts and osteoclasts
    • Chihara K, Sugimoto T. The action of GH/IGF-I/IGFBP in osteoblasts and osteoclasts. Horm Res 1997;5:45–49.
    • (1997) Horm Res , vol.5 , pp. 45-49
    • Chihara, K.1    Sugimoto, T.2
  • 85
    • 49549111375 scopus 로고    scopus 로고
    • Growth hormone, insulin-like growth factors, and the skeleton
    • Giustina A, Mazziotti G, Canalis E. Growth hormone, insulin-like growth factors, and the skeleton. Endocr Rev 2008;29(5):535–559.
    • (2008) Endocr Rev , vol.29 , Issue.5 , pp. 535-559
    • Giustina, A.1    Mazziotti, G.2    Canalis, E.3
  • 86
    • 0027457962 scopus 로고
    • Growth hormone stimulates proliferation and differentiation of normal human osteoblast-like cells in vitro
    • Kassem M, Blum W, Ristelli J, Mosekilde L, Eriksen EF. Growth hormone stimulates proliferation and differentiation of normal human osteoblast-like cells in vitro. Calcified Tissue Int 1993;52(3):222–226.
    • (1993) Calcified Tissue Int , vol.52 , Issue.3 , pp. 222-226
    • Kassem, M.1    Blum, W.2    Ristelli, J.3    Mosekilde, L.4    Eriksen, E.F.5
  • 87
    • 0242668869 scopus 로고    scopus 로고
    • Bone morphogenetic proteins, their antagonists, and the skeleton
    • Canalis E, Economides AN, Gazzerro E. Bone morphogenetic proteins, their antagonists, and the skeleton. Endocr Rev 2003;24(2):218–235.
    • (2003) Endocr Rev , vol.24 , Issue.2 , pp. 218-235
    • Canalis, E.1    Economides, A.N.2    Gazzerro, E.3
  • 88
    • 0036848938 scopus 로고    scopus 로고
    • Two years of treatment with recombinant human growth hormone increases bone mineral density in men with idiopathic osteoporosis
    • Gillberg P, Mallmin H, Petren-Mallmin M, Ljunghall S, Nilsson AG. Two years of treatment with recombinant human growth hormone increases bone mineral density in men with idiopathic osteoporosis. J Clin Endocrinol Metab 2002;87(11):4900–4906.
    • (2002) J Clin Endocrinol Metab , vol.87 , Issue.11 , pp. 4900-4906
    • Gillberg, P.1    Mallmin, H.2    Petren-Mallmin, M.3    Ljunghall, S.4    Nilsson, A.G.5
  • 89
    • 0037370988 scopus 로고    scopus 로고
    • Growth hormone increases bone mineral content in postmenopausal osteoporosis: A randomized placebo-controlled trial
    • Landin-Wilhelmsen K, Nilsson A, Bosaeus I, Bengtsson BA. Growth hormone increases bone mineral content in postmenopausal osteoporosis: A randomized placebo-controlled trial. J Bone Miner Res 2003;18(3):393–405.
    • (2003) J Bone Miner Res , vol.18 , Issue.3 , pp. 393-405
    • Landin-Wilhelmsen, K.1    Nilsson, A.2    Bosaeus, I.3    Bengtsson, B.A.4
  • 90
    • 0035134092 scopus 로고    scopus 로고
    • The influence of growth hormone deficiency, growth hormone replacement therapy, and other aspects of hypopituitarism on fracture rate and bone mineral density
    • Wuster C, Abs R, Bengtsson BA, Bennmarker H, Feldt-Rasmussen U, Hernberg-Stahl E, Monson JP, Westberg B, Wilton P. The influence of growth hormone deficiency, growth hormone replacement therapy, and other aspects of hypopituitarism on fracture rate and bone mineral density. J Bone Miner Res 2001;16(2):398–405.
    • (2001) J Bone Miner Res , vol.16 , Issue.2 , pp. 398-405
    • Wuster, C.1    Abs, R.2    Bengtsson, B.A.3    Bennmarker, H.4    Feldt-Rasmussen, U.5    Hernberg-Stahl, E.6    Monson, J.P.7    Westberg, B.8    Wilton, P.9
  • 91
    • 0033540056 scopus 로고    scopus 로고
    • Ghrelin is a growth-hormone-releasing acylated peptide from stomach
    • Kojima M, Hosoda H, Date Y, Nakazato M, Matsuo H, Kangawa K. Ghrelin is a growth-hormone-releasing acylated peptide from stomach. Nature 1999;402(6762):656–660.
    • (1999) Nature , vol.402 , Issue.6762 , pp. 656-660
    • Kojima, M.1    Hosoda, H.2    Date, Y.3    Nakazato, M.4    Matsuo, H.5    Kangawa, K.6
  • 93
    • 84856350685 scopus 로고    scopus 로고
    • The role of ghrelin in the control of energy balance
    • Kirchner H, Heppner KM, Tschop MH. The role of ghrelin in the control of energy balance. Handb Exp Pharmacol 2012;209:161–184.
    • (2012) Handb Exp Pharmacol , vol.209 , pp. 161-184
    • Kirchner, H.1    Heppner, K.M.2    Tschop, M.H.3
  • 94
    • 84867569409 scopus 로고    scopus 로고
    • Mechanisms in endocrinology: Ghrelin: The differences between acyl- and des-acyl ghrelin
    • Delhanty PJ, Neggers SJ, van der Lely AJ. Mechanisms in endocrinology: Ghrelin: The differences between acyl- and des-acyl ghrelin. Eur J Endocrinol 2012;167(5):601–608.
    • (2012) Eur J Endocrinol , vol.167 , Issue.5 , pp. 601-608
    • Delhanty, P.J.1    Neggers, S.J.2    van der Lely, A.J.3
  • 95
    • 67649124250 scopus 로고    scopus 로고
    • Targeting the ghrelin receptor to regulate food intake
    • Depoortere I. Targeting the ghrelin receptor to regulate food intake. Regul Peptides 2009;156(1–3):13–23.
    • (2009) Regul Peptides , vol.156 , Issue.1-3 , pp. 13-23
    • Depoortere, I.1
  • 96
    • 84924019193 scopus 로고    scopus 로고
    • Genetic determination of the cellular basis of the ghrelin-dependent bone remodeling
    • Ma C, Fukuda T, Ochi H, Sunamura S, Xu C, Xu R, Okawa A, Takeda S. Genetic determination of the cellular basis of the ghrelin-dependent bone remodeling. Mol Metab 2015;4(3):175–185.
    • (2015) Mol Metab , vol.4 , Issue.3 , pp. 175-185
    • Ma, C.1    Fukuda, T.2    Ochi, H.3    Sunamura, S.4    Xu, C.5    Xu, R.6    Okawa, A.7    Takeda, S.8
  • 97
    • 23844447768 scopus 로고    scopus 로고
    • Ghrelin stimulates proliferation and differentiation and inhibits apoptosis in osteoblastic MC3T3-E1 cells
    • Kim SW, Her SJ, Park SJ, Kim D, Park KS, Lee HK, Han BH, Kim MS, Shin CS, Kim SY. Ghrelin stimulates proliferation and differentiation and inhibits apoptosis in osteoblastic MC3T3-E1 cells. Bone 2005;37(3):359–369.
    • (2005) Bone , vol.37 , Issue.3 , pp. 359-369
    • Kim, S.W.1    Her, S.J.2    Park, S.J.3    Kim, D.4    Park, K.S.5    Lee, H.K.6    Han, B.H.7    Kim, M.S.8    Shin, C.S.9    Kim, S.Y.10
  • 98
    • 2942597289 scopus 로고    scopus 로고
    • Ghrelin exerts a proliferative effect on a rat pituitary somatotroph cell line via the mitogen-activated protein kinase pathway
    • Nanzer AM, Khalaf S, Mozid AM, Fowkes RC, Patel MV, Burrin JM, Grossman AB, Korbonits M. Ghrelin exerts a proliferative effect on a rat pituitary somatotroph cell line via the mitogen-activated protein kinase pathway. Eur J Endocrinol 2004;151(2):233–240.
    • (2004) Eur J Endocrinol , vol.151 , Issue.2 , pp. 233-240
    • Nanzer, A.M.1    Khalaf, S.2    Mozid, A.M.3    Fowkes, R.C.4    Patel, M.V.5    Burrin, J.M.6    Grossman, A.B.7    Korbonits, M.8
  • 100
    • 84926289333 scopus 로고    scopus 로고
    • Ghrelin increases beta-catenin level through protein kinase A activation and regulates OPG expression in rat primary osteoblasts
    • ;2015
    • Mrak E, Casati L, Pagani F, Rubinacci A, Zarattini G, Sibilia V. Ghrelin increases beta-catenin level through protein kinase A activation and regulates OPG expression in rat primary osteoblasts. Int J Endocrinol 2015;2015:10.
    • (2015) Int J Endocrinol , pp. 10
    • Mrak, E.1    Casati, L.2    Pagani, F.3    Rubinacci, A.4    Zarattini, G.5    Sibilia, V.6
  • 101
    • 84884707343 scopus 로고    scopus 로고
    • Ghrelin inhibits the apoptosis of MC3T3-E1 cells through ERK and AKT signaling pathway
    • Liang QH, Liu Y, Wu SS, Cui RR, Yuan LQ, Liao EY. Ghrelin inhibits the apoptosis of MC3T3-E1 cells through ERK and AKT signaling pathway. Toxicol Appl Pharmacol 2013;272(3):591–597.
    • (2013) Toxicol Appl Pharmacol , vol.272 , Issue.3 , pp. 591-597
    • Liang, Q.H.1    Liu, Y.2    Wu, S.S.3    Cui, R.R.4    Yuan, L.Q.5    Liao, E.Y.6
  • 106
    • 34547566399 scopus 로고    scopus 로고
    • Lack of an acute effect of ghrelin on markers of bone turnover in healthy controls and post-gastrectomy subjects
    • Huda M, Durham B, Wong S, Dovey T, McCulloch P, Kerrigan D, Pinkney J, Fraser W, Wilding J. Lack of an acute effect of ghrelin on markers of bone turnover in healthy controls and post-gastrectomy subjects. Bone 2007;41(3):406–413.
    • (2007) Bone , vol.41 , Issue.3 , pp. 406-413
    • Huda, M.1    Durham, B.2    Wong, S.3    Dovey, T.4    McCulloch, P.5    Kerrigan, D.6    Pinkney, J.7    Fraser, W.8    Wilding, J.9
  • 107
    • 46149098473 scopus 로고    scopus 로고
    • Stimulation of intramembranous bone repair in rats by ghrelin
    • Deng F, Ling J, Ma J, Liu C, Zhang W. Stimulation of intramembranous bone repair in rats by ghrelin. Exp Physiol 2008;93(7):872–879.
    • (2008) Exp Physiol , vol.93 , Issue.7 , pp. 872-879
    • Deng, F.1    Ling, J.2    Ma, J.3    Liu, C.4    Zhang, W.5
  • 109
    • 31544452274 scopus 로고    scopus 로고
    • Ghrelin and unacylated ghrelin stimulate human osteoblast growth via mitogen-activated protein kinase (MAPK)/phosphoinositide 3-kinase (PI3K) pathways in the absence of GHS-R1a
    • Delhanty PJ, van der Eerden BC, van der Velde M, Gauna C, Pols HA, Jahr H, Chiba H, van der Lely AJ, van Leeuwen JP. Ghrelin and unacylated ghrelin stimulate human osteoblast growth via mitogen-activated protein kinase (MAPK)/phosphoinositide 3-kinase (PI3K) pathways in the absence of GHS-R1a. J Endocrinol 2006;188(1):37–47.
    • (2006) J Endocrinol , vol.188 , Issue.1 , pp. 37-47
    • Delhanty, P.J.1    van der Eerden, B.C.2    van der Velde, M.3    Gauna, C.4    Pols, H.A.5    Jahr, H.6    Chiba, H.7    van der Lely, A.J.8    van Leeuwen, J.P.9
  • 110
    • 0034676324 scopus 로고    scopus 로고
    • Structure-function studies on the new growth hormone-releasing peptide, ghrelin: minimal sequence of ghrelin necessary for activation of growth hormone secretagogue receptor 1a
    • Bednarek MA, Feighner SD, Pong SS, McKee KK, Hreniuk DL, Silva MV, Warren VA, Howard AD, Van Der Ploeg LH, Heck JV. Structure-function studies on the new growth hormone-releasing peptide, ghrelin: minimal sequence of ghrelin necessary for activation of growth hormone secretagogue receptor 1a. J Med Chem 2000;43(23):4370–4376.
    • (2000) J Med Chem , vol.43 , Issue.23 , pp. 4370-4376
    • Bednarek, M.A.1    Feighner, S.D.2    Pong, S.S.3    McKee, K.K.4    Hreniuk, D.L.5    Silva, M.V.6    Warren, V.A.7    Howard, A.D.8    Van Der Ploeg, L.H.9    Heck, J.V.10
  • 113
    • 2942525145 scopus 로고    scopus 로고
    • Ala-scan of ghrelin (1-14): Interaction with the recombinant human ghrelin receptor
    • Van Craenenbroeck M, Gregoire F, De Neef P, Robberecht P, Perret J. Ala-scan of ghrelin (1-14): Interaction with the recombinant human ghrelin receptor. Peptides 2004;25(6):959–965.
    • (2004) Peptides , vol.25 , Issue.6 , pp. 959-965
    • Van Craenenbroeck, M.1    Gregoire, F.2    De Neef, P.3    Robberecht, P.4    Perret, J.5
  • 118
    • 84870501288 scopus 로고    scopus 로고
    • Metabolism of growth hormone releasing peptides
    • Thomas A, Delahaut P, Krug O, Schanzer W, Thevis M. Metabolism of growth hormone releasing peptides. Anal Chem 2012;84(23):10252–10259.
    • (2012) Anal Chem , vol.84 , Issue.23 , pp. 10252-10259
    • Thomas, A.1    Delahaut, P.2    Krug, O.3    Schanzer, W.4    Thevis, M.5
  • 122
    • 84905453700 scopus 로고    scopus 로고
    • Cytokines and hormones that contribute to the positive association between fat and bone
    • Naot D, Cornish J. Cytokines and hormones that contribute to the positive association between fat and bone. Front Endocrinol 2014;5(70):1–9.
    • (2014) Front Endocrinol , vol.5 , Issue.70 , pp. 1-9
    • Naot, D.1    Cornish, J.2
  • 124
    • 0023579739 scopus 로고
    • Purification and characterization of a peptide from amyloid-rich pancreases of type 2 diabetic patients
    • Cooper G, Willis A, Clark A, Turner R, Sim R, Reid K. Purification and characterization of a peptide from amyloid-rich pancreases of type 2 diabetic patients. Proc Natl Acad Sci USA 1987;84:8628–8632.
    • (1987) Proc Natl Acad Sci USA , vol.84 , pp. 8628-8632
    • Cooper, G.1    Willis, A.2    Clark, A.3    Turner, R.4    Sim, R.5    Reid, K.6
  • 125
    • 0028354142 scopus 로고
    • Amylin compared with calcitonin gene-related peptide: Structure, biology, and relevance to metabolic disease
    • Cooper GJS. Amylin compared with calcitonin gene-related peptide: Structure, biology, and relevance to metabolic disease. Endocr Rev 1994;15(2):163–201.
    • (1994) Endocr Rev , vol.15 , Issue.2 , pp. 163-201
    • Cooper, G.J.S.1
  • 126
    • 0027298124 scopus 로고
    • Amylin inhibits bone resorption by a direct effect on the motility of rat osteoclasts
    • Alam A, Moonga B, Bevis P, Huang C, Zaidi M. Amylin inhibits bone resorption by a direct effect on the motility of rat osteoclasts. Exp Physiol 1993;78(2):183–196.
    • (1993) Exp Physiol , vol.78 , Issue.2 , pp. 183-196
    • Alam, A.1    Moonga, B.2    Bevis, P.3    Huang, C.4    Zaidi, M.5
  • 127
    • 0024435068 scopus 로고
    • Amylinamide, bone conservation, and pancreatic beta cells
    • Macintyre I. Amylinamide, bone conservation, and pancreatic beta cells. Lancet 1989;334(8670):1026–1027.
    • (1989) Lancet , vol.334 , Issue.8670 , pp. 1026-1027
    • Macintyre, I.1
  • 128
    • 0027477606 scopus 로고
    • Inhibitory effect of amylin on basal and parathyroid hormone-stimulated bone resorption in cultured neonatal mouse calvaria
    • Pietschmann P, Farsoudi KH, Hoffmann O, Klaushofer K, Hörandner H, Peterlik M. Inhibitory effect of amylin on basal and parathyroid hormone-stimulated bone resorption in cultured neonatal mouse calvaria. Bone 1993;14(2):167–172.
    • (1993) Bone , vol.14 , Issue.2 , pp. 167-172
    • Pietschmann, P.1    Farsoudi, K.H.2    Hoffmann, O.3    Klaushofer, K.4    Hörandner, H.5    Peterlik, M.6
  • 129
    • 0036366984 scopus 로고    scopus 로고
    • Amylin and adrenomedullin: Novel regulators of bone growth
    • Cornish J, Naot D. Amylin and adrenomedullin: Novel regulators of bone growth. Curr Pharm Des 2002;8(23):2009–2021.
    • (2002) Curr Pharm Des , vol.8 , Issue.23 , pp. 2009-2021
    • Cornish, J.1    Naot, D.2
  • 130
    • 0028950047 scopus 로고
    • Amylin stimulates osteoblast proliferation and increases mineralized bone volume in adult mice
    • Cornish J, Callon KE, Cooper GJS, Reid IR. Amylin stimulates osteoblast proliferation and increases mineralized bone volume in adult mice. Biochem Biophys Res Commun 1995;207(1):133–139.
    • (1995) Biochem Biophys Res Commun , vol.207 , Issue.1 , pp. 133-139
    • Cornish, J.1    Callon, K.E.2    Cooper, G.J.S.3    Reid, I.R.4
  • 132
    • 0001000705 scopus 로고    scopus 로고
    • Calcitonin-gene related peptide, amylin, or parathyroid hormone stimulate (in vitro) biomineralization (Abstract)
    • Burns MD, Kawase T. Calcitonin-gene related peptide, amylin, or parathyroid hormone stimulate (in vitro) biomineralization (Abstract). J Bone Miner Res 1997;12:392.
    • (1997) J Bone Miner Res , vol.12 , pp. 392
    • Burns, M.D.1    Kawase, T.2
  • 134
    • 0031741159 scopus 로고    scopus 로고
    • Systemic administration of amylin increases bone mass, linear growth, and adiposity in adult male mice
    • Cornish J, Callon KE, King AR, Cooper GJS, Reid IR. Systemic administration of amylin increases bone mass, linear growth, and adiposity in adult male mice. Am J Physiol 1998;275(4):694–699.
    • (1998) Am J Physiol , vol.275 , Issue.4 , pp. 694-699
    • Cornish, J.1    Callon, K.E.2    King, A.R.3    Cooper, G.J.S.4    Reid, I.R.5
  • 136
    • 12144289840 scopus 로고    scopus 로고
    • Amylin fasting plasma levels are decreased in patients with osteoporosis
    • Bronský J, Průša R. Amylin fasting plasma levels are decreased in patients with osteoporosis. Osteoporos Int 2004;15(3):243–247.
    • (2004) Osteoporos Int , vol.15 , Issue.3 , pp. 243-247
    • Bronský, J.1    Průša, R.2
  • 137
    • 77649187443 scopus 로고    scopus 로고
    • Reduced amylin levels are associated with low bone mineral density in women with anorexia nervosa
    • Wojcik MH, Meenaghan E, Lawson EA, Misra M, Klibanski A, Miller KK. Reduced amylin levels are associated with low bone mineral density in women with anorexia nervosa. Bone 2010;46(3):796–800.
    • (2010) Bone , vol.46 , Issue.3 , pp. 796-800
    • Wojcik, M.H.1    Meenaghan, E.2    Lawson, E.A.3    Misra, M.4    Klibanski, A.5    Miller, K.K.6
  • 140
    • 84859432039 scopus 로고    scopus 로고
    • Synthesis and evaluation of disulfide bond mimetics of amylin-(1–8) as agents to treat osteoporosis
    • Kowalczyk R, Harris PWR, Brimble MA, Callon KE, Watson M, Cornish J. Synthesis and evaluation of disulfide bond mimetics of amylin-(1–8) as agents to treat osteoporosis. Bioorg Med Chem 2012;20(8):2661–2668.
    • (2012) Bioorg Med Chem , vol.20 , Issue.8 , pp. 2661-2668
    • Kowalczyk, R.1    Harris, P.W.R.2    Brimble, M.A.3    Callon, K.E.4    Watson, M.5    Cornish, J.6
  • 141
    • 84866904225 scopus 로고    scopus 로고
    • How to blast osteoblasts? Novel dicarba analogues of amylin-(1–8) to treat osteoporosis
    • Kowalczyk R, Brimble MA, Callon KE, Watson M, Cornish J. How to blast osteoblasts? Novel dicarba analogues of amylin-(1–8) to treat osteoporosis. Bioorg Med Chem 2012;20(20):6011–6018.
    • (2012) Bioorg Med Chem , vol.20 , Issue.20 , pp. 6011-6018
    • Kowalczyk, R.1    Brimble, M.A.2    Callon, K.E.3    Watson, M.4    Cornish, J.5
  • 142
    • 0035655635 scopus 로고    scopus 로고
    • Preptin derived from proinsulin-like growth factor II (proIGF-II) is secreted from pancreatic islet beta-cells and enhances insulin secretion
    • Buchanan C, Phillips A, Cooper G. Preptin derived from proinsulin-like growth factor II (proIGF-II) is secreted from pancreatic islet beta-cells and enhances insulin secretion. Biochem J 2001;360:431–439.
    • (2001) Biochem J , vol.360 , pp. 431-439
    • Buchanan, C.1    Phillips, A.2    Cooper, G.3
  • 143
    • 84884784880 scopus 로고    scopus 로고
    • Preptin analogues: Chemical synthesis, secondary structure and biological studies
    • Buchanan CM, Peng Z, Cefre A, Sarojini V. Preptin analogues: Chemical synthesis, secondary structure and biological studies. Chem Biol Drug Des 2013;82(4):429–437.
    • (2013) Chem Biol Drug Des , vol.82 , Issue.4 , pp. 429-437
    • Buchanan, C.M.1    Peng, Z.2    Cefre, A.3    Sarojini, V.4
  • 144
    • 0036345441 scopus 로고    scopus 로고
    • Use of site-specific antibodies to characterize the circulating form of big insulin-like growth factor II in patients with hepatitis C-associated osteosclerosis
    • Khosla S, Ballard FJ, Conover CA. Use of site-specific antibodies to characterize the circulating form of big insulin-like growth factor II in patients with hepatitis C-associated osteosclerosis. J Clin Endocr Metab 2002;87(8):3867–3870.
    • (2002) J Clin Endocr Metab , vol.87 , Issue.8 , pp. 3867-3870
    • Khosla, S.1    Ballard, F.J.2    Conover, C.A.3
  • 145
    • 84873034708 scopus 로고    scopus 로고
    • Lower circulating preptin levels in male patients with osteoporosis are correlated with bone mineral density and bone formation
    • Li N, Zheng Y-B, Han J, Liang W, Wang J-Y, Zhou J-R, Shen Y, Zhang J. Lower circulating preptin levels in male patients with osteoporosis are correlated with bone mineral density and bone formation. BMC Musculoskel Dis 2013;14(1):49.
    • (2013) BMC Musculoskel Dis , vol.14 , Issue.1 , pp. 49
    • Li, N.1    Zheng, Y.-B.2    Han, J.3    Liang, W.4    Wang, J.-Y.5    Zhou, J.-R.6    Shen, Y.7    Zhang, J.8
  • 148
    • 84876219685 scopus 로고    scopus 로고
    • Effects and differentiation activity of IGF-I, IGF-II, insulin and preptin on human primary bone cells
    • Bosetti M, Sabbatini M, Nicolì E, Fusaro L, Cannas M. Effects and differentiation activity of IGF-I, IGF-II, insulin and preptin on human primary bone cells. Growth Factors 2013;31(2):57–65.
    • (2013) Growth Factors , vol.31 , Issue.2 , pp. 57-65
    • Bosetti, M.1    Sabbatini, M.2    Nicolì, E.3    Fusaro, L.4    Cannas, M.5
  • 149
    • 77951666601 scopus 로고    scopus 로고
    • Connective tissue growth factor is a downstream mediator for preptin-induced proliferation and differentiation in human osteoblasts
    • Liu Y, Lu Y, Liu W, Xie H, Luo X, Wu X, Yuan L, Liao E. Connective tissue growth factor is a downstream mediator for preptin-induced proliferation and differentiation in human osteoblasts. Amino Acids 2010;38:763–769.
    • (2010) Amino Acids , vol.38 , pp. 763-769
    • Liu, Y.1    Lu, Y.2    Liu, W.3    Xie, H.4    Luo, X.5    Wu, X.6    Yuan, L.7    Liao, E.8
  • 151
    • 84974668464 scopus 로고    scopus 로고
    • Structure activity relationship (SAR) study on the peptide hormone preptin, a novel anabolic agent for the treatment of osteoporosis
    • Auckland, New Zealand, The University of Auckland
    • Amso Z, Kowalczyk R, Park Y-E, Watson M, Callon KE, Cornish J, Brimble MA. Structure activity relationship (SAR) study on the peptide hormone preptin, a novel anabolic agent for the treatment of osteoporosis. School of Chemical Sciences. Auckland, New Zealand: The University of Auckland; 2016.
    • (2016) School of Chemical Sciences
    • Amso, Z.1    Kowalczyk, R.2    Park, Y.-E.3    Watson, M.4    Callon, K.E.5    Cornish, J.6    Brimble, M.A.7
  • 152
    • 84974668463 scopus 로고    scopus 로고
    • Synthesis and in vitro osteoblast proliferative activity of cyclic preptin analogues
    • Auckland, New Zealand, The University of Auckland
    • Amso Z, Kowalczyk R, Park Y-E, Cornish J, Brimble MA. Synthesis and in vitro osteoblast proliferative activity of cyclic preptin analogues. School of Chemical Sciences. Auckland, New Zealand: The University of Auckland; 2016.
    • (2016) School of Chemical Sciences
    • Amso, Z.1    Kowalczyk, R.2    Park, Y.-E.3    Cornish, J.4    Brimble, M.A.5
  • 153
    • 84902547011 scopus 로고    scopus 로고
    • Synthesis of truncated analogues of preptin-(1–16), and investigation of their ability to stimulate osteoblast proliferation
    • Kowalczyk R, Yang SH, Brimble MA, Callon KE, Watson M, Park Y-E, Cornish J. Synthesis of truncated analogues of preptin-(1–16), and investigation of their ability to stimulate osteoblast proliferation. Bioorg Med Chem 2014;22(14):3565–3572.
    • (2014) Bioorg Med Chem , vol.22 , Issue.14 , pp. 3565-3572
    • Kowalczyk, R.1    Yang, S.H.2    Brimble, M.A.3    Callon, K.E.4    Watson, M.5    Park, Y.-E.6    Cornish, J.7
  • 156
    • 84892702500 scopus 로고    scopus 로고
    • The association between the serum C-peptide level and bone mineral density
    • Li Y, Liu H, Sato Y. The association between the serum C-peptide level and bone mineral density. PLoS One 2013;8(12):e83107.
    • (2013) PLoS One , vol.8 , Issue.12
    • Li, Y.1    Liu, H.2    Sato, Y.3
  • 158
    • 0025312570 scopus 로고
    • C-type natriuretic peptide (CNP): A new member of natriuretic peptide family identified in porcine brain
    • Sudoh T, Minamino N, Kangawa K, Matsuo H. C-type natriuretic peptide (CNP): A new member of natriuretic peptide family identified in porcine brain. Biochem Biophys Res Commun 1990;168(2):863–870.
    • (1990) Biochem Biophys Res Commun , vol.168 , Issue.2 , pp. 863-870
    • Sudoh, T.1    Minamino, N.2    Kangawa, K.3    Matsuo, H.4
  • 159
    • 32444444836 scopus 로고    scopus 로고
    • Natriuretic peptides, their receptors, and cyclic guanosine monophosphate-dependent signaling functions
    • Potter LR, Abbey-Hosch S, Dickey DM. Natriuretic peptides, their receptors, and cyclic guanosine monophosphate-dependent signaling functions. Endocr Rev 2006;27(1):47–72.
    • (2006) Endocr Rev , vol.27 , Issue.1 , pp. 47-72
    • Potter, L.R.1    Abbey-Hosch, S.2    Dickey, D.M.3
  • 160
    • 0027419064 scopus 로고
    • Detection of C-type natriuretic peptide (CNP) transcript in the rat heart and immune organs
    • Vollmar AM, Gerbes AL, Nemer M, Schulz R. Detection of C-type natriuretic peptide (CNP) transcript in the rat heart and immune organs. Endocrinology 1993;132(4):1872–1874.
    • (1993) Endocrinology , vol.132 , Issue.4 , pp. 1872-1874
    • Vollmar, A.M.1    Gerbes, A.L.2    Nemer, M.3    Schulz, R.4
  • 161
    • 0026703056 scopus 로고
    • Endothelial production of C-type natriuretic peptide and its marked augmentation by transforming growth factor-beta. Possible existence of “vascular natriuretic peptide system
    • Suga S, Nakao K, Itoh H, Komatsu Y, Ogawa Y, Hama N, Imura H. Endothelial production of C-type natriuretic peptide and its marked augmentation by transforming growth factor-beta. Possible existence of “vascular natriuretic peptide system.” J Clin Invest 1992;90(3):1145–1149.
    • (1992) J Clin Invest , vol.90 , Issue.3 , pp. 1145-1149
    • Suga, S.1    Nakao, K.2    Itoh, H.3    Komatsu, Y.4    Ogawa, Y.5    Hama, N.6    Imura, H.7
  • 163
    • 0032974166 scopus 로고    scopus 로고
    • Correlation between induction of expression of biglycan and mineralization by C-type natriuretic peptide in osteoblastic cells
    • Inoue A, Hayakawa T, Otsuka E, Kamiya A, Suzuki Y, Hirose S, Hagiwara H. Correlation between induction of expression of biglycan and mineralization by C-type natriuretic peptide in osteoblastic cells. J Biochem 1999;125(1):103–108.
    • (1999) J Biochem , vol.125 , Issue.1 , pp. 103-108
    • Inoue, A.1    Hayakawa, T.2    Otsuka, E.3    Kamiya, A.4    Suzuki, Y.5    Hirose, S.6    Hagiwara, H.7
  • 164
    • 0029026863 scopus 로고
    • C-type natriuretic peptide increases bone resorption in 1,25-dihydroxyvitamin D3-stimulated mouse bone marrow cultures
    • Holliday LS, Dean AD, Greenwald JE, Glucks SL. C-type natriuretic peptide increases bone resorption in 1,25-dihydroxyvitamin D3-stimulated mouse bone marrow cultures. J Biol Chem 1995;270(32):18983–18989.
    • (1995) J Biol Chem , vol.270 , Issue.32 , pp. 18983-18989
    • Holliday, L.S.1    Dean, A.D.2    Greenwald, J.E.3    Glucks, S.L.4
  • 167
    • 77958484651 scopus 로고    scopus 로고
    • Vessel dilator and C-type natriuretic peptide enhance the proliferation of human osteoblasts
    • Lenz A, Bennett M, Skelton WPt, Vesely DL. Vessel dilator and C-type natriuretic peptide enhance the proliferation of human osteoblasts. Pediatr Res 2010;68(5):405–408.
    • (2010) Pediatr Res , vol.68 , Issue.5 , pp. 405-408
    • Lenz, A.1    Bennett, M.2    Skelton, W.P.3    Vesely, D.L.4
  • 168
    • 33144468578 scopus 로고    scopus 로고
    • C-type natriuretic peptide enhances osteogenic protein-1-induced osteoblastic cell differentiation via Smad5 phosphorylation
    • Yeh LC, Zavala MC, Lee JC. C-type natriuretic peptide enhances osteogenic protein-1-induced osteoblastic cell differentiation via Smad5 phosphorylation. J Cell Biochem 2006;97(3):494–500.
    • (2006) J Cell Biochem , vol.97 , Issue.3 , pp. 494-500
    • Yeh, L.C.1    Zavala, M.C.2    Lee, J.C.3
  • 169
    • 0034574298 scopus 로고    scopus 로고
    • How cells read TGF-beta signals
    • Massague J. How cells read TGF-beta signals. Nat Rev Mol Cell Biol 2000;1(3):169–178.
    • (2000) Nat Rev Mol Cell Biol , vol.1 , Issue.3 , pp. 169-178
    • Massague, J.1
  • 171
    • 39049170428 scopus 로고    scopus 로고
    • The receptor attributable to C-type natriuretic peptide-induced differentiation of osteoblasts is switched from type B- to type C-natriuretic peptide receptor with aging
    • Kaneki H, Kurokawa M, Ide H. The receptor attributable to C-type natriuretic peptide-induced differentiation of osteoblasts is switched from type B- to type C-natriuretic peptide receptor with aging. J Cell Biochem 2008;103(3):753–764.
    • (2008) J Cell Biochem , vol.103 , Issue.3 , pp. 753-764
    • Kaneki, H.1    Kurokawa, M.2    Ide, H.3
  • 172
    • 34047199291 scopus 로고    scopus 로고
    • C-type natriuretic peptide regulates endochondral bone growth through p38 MAP kinase-dependent and -independent pathways
    • Agoston H, Khan S, James CG, Gillespie JR, Serra R, Stanton LA, Beier F. C-type natriuretic peptide regulates endochondral bone growth through p38 MAP kinase-dependent and -independent pathways. BMC Dev Biol 2007;7:18.
    • (2007) BMC Dev Biol , vol.7 , pp. 18
    • Agoston, H.1    Khan, S.2    James, C.G.3    Gillespie, J.R.4    Serra, R.5    Stanton, L.A.6    Beier, F.7
  • 175
  • 176
    • 40749090890 scopus 로고    scopus 로고
    • Differential effects of natriuretic peptide stimulation on tissue-engineered cartilage
    • Waldman SD, Usmani Y, Tse MY, Pang SC. Differential effects of natriuretic peptide stimulation on tissue-engineered cartilage. Tissue Eng 2008;14(3):441–448.
    • (2008) Tissue Eng , vol.14 , Issue.3 , pp. 441-448
    • Waldman, S.D.1    Usmani, Y.2    Tse, M.Y.3    Pang, S.C.4
  • 177
    • 27944483696 scopus 로고    scopus 로고
    • Interaction of fibroblast growth factor and C-natriuretic peptide signaling in regulation of chondrocyte proliferation and extracellular matrix homeostasis
    • Krejci P, Masri B, Fontaine V, Mekikian PB, Weis M, Prats H, Wilcox WR. Interaction of fibroblast growth factor and C-natriuretic peptide signaling in regulation of chondrocyte proliferation and extracellular matrix homeostasis. J Cell Sci 2005;118(Pt 21):5089–5100.
    • (2005) J Cell Sci , vol.118 , pp. 5089-5100
    • Krejci, P.1    Masri, B.2    Fontaine, V.3    Mekikian, P.B.4    Weis, M.5    Prats, H.6    Wilcox, W.R.7
  • 178
    • 0028887820 scopus 로고
    • Role of natriuretic peptide clearance receptor in in vivo control of C-type natriuretic peptide
    • Brandt RR, Heublein DM, Aarhus LL, Lewicki JA, Burnett JC, Jr. Role of natriuretic peptide clearance receptor in in vivo control of C-type natriuretic peptide. Am J Physiol 1995;269(1 Pt 2):H326–H331.
    • (1995) Am J Physiol , vol.269 , Issue.1 , pp. H326-H331
    • Brandt, R.R.1    Heublein, D.M.2    Aarhus, L.L.3    Lewicki, J.A.4    Burnett, J.C.5
  • 179
    • 0030835673 scopus 로고    scopus 로고
    • Neutral endopeptidase regulates C-type natriuretic peptide metabolism but does not potentiate its bioactivity in vivo
    • Brandt RR, Mattingly MT, Clavell AL, Barclay PL, Burnett JC, Jr. Neutral endopeptidase regulates C-type natriuretic peptide metabolism but does not potentiate its bioactivity in vivo. Hypertension 1997;30(2 Pt 1):184–190.
    • (1997) Hypertension , vol.30 , Issue.2 , pp. 184-190
    • Brandt, R.R.1    Mattingly, M.T.2    Clavell, A.L.3    Barclay, P.L.4    Burnett, J.C.5
  • 181
    • 77951919525 scopus 로고    scopus 로고
    • C-type natriuretic peptide: Structural studies, fragment synthesis, and preliminary biological evaluation in human osteosarcoma cell lines
    • Shaikh N, Russo L, Papaleo E, Giannoni P, De Gioia L, Nicotra F, Quarto R, Cipolla L. C-type natriuretic peptide: Structural studies, fragment synthesis, and preliminary biological evaluation in human osteosarcoma cell lines. Biopolymers 2010;94(2):213–219.
    • (2010) Biopolymers , vol.94 , Issue.2 , pp. 213-219
    • Shaikh, N.1    Russo, L.2    Papaleo, E.3    Giannoni, P.4    De Gioia, L.5    Nicotra, F.6    Quarto, R.7    Cipolla, L.8
  • 185
    • 0033405442 scopus 로고    scopus 로고
    • Endothelin and post-ganglionic sympathetic neurons
    • Damon DH. Endothelin and post-ganglionic sympathetic neurons. Clin Exp Pharmacol Physiol 1999;26(12):1000–1003.
    • (1999) Clin Exp Pharmacol Physiol , vol.26 , Issue.12 , pp. 1000-1003
    • Damon, D.H.1
  • 186
    • 0035060288 scopus 로고    scopus 로고
    • Endothelin-1 expression in long-term cultures of fetal rat calvarial osteoblasts: Regulation by BMP-7
    • Kitten AM, Andrews CJ. Endothelin-1 expression in long-term cultures of fetal rat calvarial osteoblasts: Regulation by BMP-7. J Cell Physiol 2001;187(2):218–225.
    • (2001) J Cell Physiol , vol.187 , Issue.2 , pp. 218-225
    • Kitten, A.M.1    Andrews, C.J.2
  • 187
    • 0031917967 scopus 로고    scopus 로고
    • Gene expression of bone matrix proteins and endothelin receptors in endothelin-1-deficient mice revealed by in situ hybridization
    • Kitano Y, Kurihara H, Kurihara Y, Maemura K, Ryo Y, Yazaki Y, Harii K. Gene expression of bone matrix proteins and endothelin receptors in endothelin-1-deficient mice revealed by in situ hybridization. J Bone Miner Res 1998;13(2):237–244.
    • (1998) J Bone Miner Res , vol.13 , Issue.2 , pp. 237-244
    • Kitano, Y.1    Kurihara, H.2    Kurihara, Y.3    Maemura, K.4    Ryo, Y.5    Yazaki, Y.6    Harii, K.7
  • 188
    • 0027482323 scopus 로고
    • Endothelin modulates osteopontin and osteocalcin messenger ribonucleic acid expression in rat osteoblastic osteosarcoma cells
    • Shioide M, Noda M. Endothelin modulates osteopontin and osteocalcin messenger ribonucleic acid expression in rat osteoblastic osteosarcoma cells. J Cell Biochem 1993;53(2):176–180.
    • (1993) J Cell Biochem , vol.53 , Issue.2 , pp. 176-180
    • Shioide, M.1    Noda, M.2
  • 189
    • 0026758607 scopus 로고
    • Endothelin-1 actions on resorption, collagen and noncollagen protein synthesis, and phosphatidylinositol turnover in bone organ cultures
    • Tatrai A, Foster S, Lakatos P, Shankar G, Stern PH. Endothelin-1 actions on resorption, collagen and noncollagen protein synthesis, and phosphatidylinositol turnover in bone organ cultures. Endocrinology 1992;131(2):603–607.
    • (1992) Endocrinology , vol.131 , Issue.2 , pp. 603-607
    • Tatrai, A.1    Foster, S.2    Lakatos, P.3    Shankar, G.4    Stern, P.H.5
  • 190
    • 0030612422 scopus 로고    scopus 로고
    • ETA receptor mediates the signaling of endothelin-1 in osteoblast-like cells
    • Suzuki A, Shinoda J, Watanabe-Tomita Y, Ozaki N, Oiso Y, Kozawa O. ETA receptor mediates the signaling of endothelin-1 in osteoblast-like cells. Bone 1997;21(2):143–146.
    • (1997) Bone , vol.21 , Issue.2 , pp. 143-146
    • Suzuki, A.1    Shinoda, J.2    Watanabe-Tomita, Y.3    Ozaki, N.4    Oiso, Y.5    Kozawa, O.6
  • 191
    • 0141527496 scopus 로고    scopus 로고
    • Endothelin-1 promotes osteoprogenitor proliferation and differentiation in fetal rat calvarial cell cultures
    • von Schroeder HP, Veillette CJ, Payandeh J, Qureshi A, Heersche JN. Endothelin-1 promotes osteoprogenitor proliferation and differentiation in fetal rat calvarial cell cultures. Bone 2003;33(4):673–684.
    • (2003) Bone , vol.33 , Issue.4 , pp. 673-684
    • von Schroeder, H.P.1    Veillette, C.J.2    Payandeh, J.3    Qureshi, A.4    Heersche, J.N.5
  • 193
    • 33846826885 scopus 로고    scopus 로고
    • Endothelin signaling in osteoblasts: Global genome view and implication of the calcineurin/NFAT pathway
    • Van Sant C, Wang G, Anderson MG, Trask OJ, Lesniewski R, Semizarov D. Endothelin signaling in osteoblasts: Global genome view and implication of the calcineurin/NFAT pathway. Mol Cancer Ther 2007;6(1):253–261.
    • (2007) Mol Cancer Ther , vol.6 , Issue.1 , pp. 253-261
    • Van Sant, C.1    Wang, G.2    Anderson, M.G.3    Trask, O.J.4    Lesniewski, R.5    Semizarov, D.6
  • 194
    • 0031737911 scopus 로고    scopus 로고
    • Endothelins inhibit the mineralization of osteoblastic MC3T3-E1 cells through the A-type endothelin receptor
    • Hiruma Y, Inoue A, Shiohama A, Otsuka E, Hirose S, Yamaguchi A, Hagiwara H. Endothelins inhibit the mineralization of osteoblastic MC3T3-E1 cells through the A-type endothelin receptor. Am J Physiol 1998;275(4 Pt 2):R1099–R1105.
    • (1998) Am J Physiol , vol.275 , Issue.4 , pp. R1099-R1105
    • Hiruma, Y.1    Inoue, A.2    Shiohama, A.3    Otsuka, E.4    Hirose, S.5    Yamaguchi, A.6    Hagiwara, H.7
  • 197
    • 0037098918 scopus 로고    scopus 로고
    • Expression and regulatory role of receptors for vasoactive intestinal peptide in bone cells
    • Lundberg P, Lerner UH. Expression and regulatory role of receptors for vasoactive intestinal peptide in bone cells. Microsc Res Tech 2002;58(2):98–103.
    • (2002) Microsc Res Tech , vol.58 , Issue.2 , pp. 98-103
    • Lundberg, P.1    Lerner, U.H.2
  • 198
    • 29244481953 scopus 로고    scopus 로고
    • Sympathetic nervous system and bone remodeling
    • Chenu C, Marenzana M. Sympathetic nervous system and bone remodeling. Joint Bone Spine 2005;72:481–483.
    • (2005) Joint Bone Spine , vol.72 , pp. 481-483
    • Chenu, C.1    Marenzana, M.2
  • 201
    • 0030962179 scopus 로고    scopus 로고
    • Pituitary adenylate cyclase activating polypeptide (PACAP) and vasoactive intestinal peptide (VIP) stimulate interleukin-6 production through the third subtype of PACAP/VIP receptor in rat bone marrow-derived stromal cells
    • Cai Y, Xin X, Shim G-J, Mokuno Y, Uehara H, Yamada T, Agui T, Matsumoto K. Pituitary adenylate cyclase activating polypeptide (PACAP) and vasoactive intestinal peptide (VIP) stimulate interleukin-6 production through the third subtype of PACAP/VIP receptor in rat bone marrow-derived stromal cells. Endocrinology 1997;138(6):2515–2520.
    • (1997) Endocrinology , vol.138 , Issue.6 , pp. 2515-2520
    • Cai, Y.1    Xin, X.2    Shim, G.-J.3    Mokuno, Y.4    Uehara, H.5    Yamada, T.6    Agui, T.7    Matsumoto, K.8
  • 202
    • 84868211615 scopus 로고    scopus 로고
    • Changes in pituitary adenylate cyclase-activating peptide 27-like immunoreactive nervous structures in the porcine descending colon during selected pathological processes
    • Gonkowski S, Calka J. Changes in pituitary adenylate cyclase-activating peptide 27-like immunoreactive nervous structures in the porcine descending colon during selected pathological processes. J Mol Neurosci 2012;48(3):777–787.
    • (2012) J Mol Neurosci , vol.48 , Issue.3 , pp. 777-787
    • Gonkowski, S.1    Calka, J.2
  • 203
    • 0035114914 scopus 로고    scopus 로고
    • Vasoactive intestinal peptide (VIP)/pituitary adenylate cyclase-activating peptide receptor subtypes in mouse calvarial osteoblasts: Presence of VIP-2 receptors and differentiation-induced expression of VIP-1 receptors 1
    • Lundberg P, Lundgren I, Mukohyama H, Lehenkari PP, Horton MA, Lerner UH. Vasoactive intestinal peptide (VIP)/pituitary adenylate cyclase-activating peptide receptor subtypes in mouse calvarial osteoblasts: Presence of VIP-2 receptors and differentiation-induced expression of VIP-1 receptors 1. Endocrinology 2001;142(1):339–347.
    • (2001) Endocrinology , vol.142 , Issue.1 , pp. 339-347
    • Lundberg, P.1    Lundgren, I.2    Mukohyama, H.3    Lehenkari, P.P.4    Horton, M.A.5    Lerner, U.H.6
  • 204
    • 0028264854 scopus 로고
    • Pituitary adenylate cyclase-activating polypeptide induces cAMP production independently from vasoactive intestinal polypeptide in osteoblast-like cells
    • Suzuki A, Kotoyori J, Oiso Y, Kozawa O. Pituitary adenylate cyclase-activating polypeptide induces cAMP production independently from vasoactive intestinal polypeptide in osteoblast-like cells. Cell Signal 1994;6(1):11–16.
    • (1994) Cell Signal , vol.6 , Issue.1 , pp. 11-16
    • Suzuki, A.1    Kotoyori, J.2    Oiso, Y.3    Kozawa, O.4
  • 206
    • 37049178084 scopus 로고
    • Innervation of periosteum and bone by sympathetic vasoactive intestinal peptide-containing nerve fibers
    • Hohmann EL, Elde RP, Rysavy JA, Einzig S, Gebhard RL. Innervation of periosteum and bone by sympathetic vasoactive intestinal peptide-containing nerve fibers. Science 1986;232(4752):868–871.
    • (1986) Science , vol.232 , Issue.4752 , pp. 868-871
    • Hohmann, E.L.1    Elde, R.P.2    Rysavy, J.A.3    Einzig, S.4    Gebhard, R.L.5
  • 207
    • 0030944068 scopus 로고    scopus 로고
    • Immunocytochemical demonstration of pituitary adenylate cyclase activating polypeptide (PACAP) in the porcine epiphyseal cartilage canals
    • Strange-Vognsen HH, Arnbjerg J, Hannibal J. Immunocytochemical demonstration of pituitary adenylate cyclase activating polypeptide (PACAP) in the porcine epiphyseal cartilage canals. Neuropeptides 1997;31(2):137–141.
    • (1997) Neuropeptides , vol.31 , Issue.2 , pp. 137-141
    • Strange-Vognsen, H.H.1    Arnbjerg, J.2    Hannibal, J.3
  • 208
    • 0033619702 scopus 로고    scopus 로고
    • Neuro-hormonal control of bone metabolism: Vasoactive intestinal peptide stimulates alkaline phosphatase activity and mRNA expression in mouse calvarial osteoblasts as well as calcium accumulation mineralized bone nodules
    • Lundberg P, Bostrom I, Mukohyama H, Bjurholm A, Smans K, Lerner UH. Neuro-hormonal control of bone metabolism: Vasoactive intestinal peptide stimulates alkaline phosphatase activity and mRNA expression in mouse calvarial osteoblasts as well as calcium accumulation mineralized bone nodules. Regul Pept 1999;85(1):47–58.
    • (1999) Regul Pept , vol.85 , Issue.1 , pp. 47-58
    • Lundberg, P.1    Bostrom, I.2    Mukohyama, H.3    Bjurholm, A.4    Smans, K.5    Lerner, U.H.6
  • 209
    • 84927766908 scopus 로고    scopus 로고
    • Neuropeptide Y, substance P, and human bone morphogenetic protein 2 stimulate human osteoblast osteogenic activity by enhancing gap junction intercellular communication
    • Ma WH, Liu YJ, Wang W, Zhang YZ. Neuropeptide Y, substance P, and human bone morphogenetic protein 2 stimulate human osteoblast osteogenic activity by enhancing gap junction intercellular communication. Braz J Med Biol Res 2015;48(4):299–307.
    • (2015) Braz J Med Biol Res , vol.48 , Issue.4 , pp. 299-307
    • Ma, W.H.1    Liu, Y.J.2    Wang, W.3    Zhang, Y.Z.4
  • 210
    • 84878421499 scopus 로고    scopus 로고
    • Neuropeptides stimulate human osteoblast activity and promote gap junctional intercellular communication
    • Ma W, Zhang X, Shi S, Zhang Y. Neuropeptides stimulate human osteoblast activity and promote gap junctional intercellular communication. Neuropeptides 2013;47(3):179–186.
    • (2013) Neuropeptides , vol.47 , Issue.3 , pp. 179-186
    • Ma, W.1    Zhang, X.2    Shi, S.3    Zhang, Y.4
  • 212
    • 80055000834 scopus 로고    scopus 로고
    • The neuropeptide VIP regulates the expression of osteoclastogenic factors in osteoblasts
    • Persson E, Lerner UH. The neuropeptide VIP regulates the expression of osteoclastogenic factors in osteoblasts. J Cell Biochem 2011;112(12):3732–3741.
    • (2011) J Cell Biochem , vol.112 , Issue.12 , pp. 3732-3741
    • Persson, E.1    Lerner, U.H.2
  • 213
    • 0031227950 scopus 로고    scopus 로고
    • Pituitary adenylyl cyclase-activating polypeptides and vasoactive intestinal peptide inhibit bone resorption by isolated rabbit osteoclasts
    • Winding B, Wiltink A, Foged NT. Pituitary adenylyl cyclase-activating polypeptides and vasoactive intestinal peptide inhibit bone resorption by isolated rabbit osteoclasts. Exp Physiol 1997;82(5):871–886.
    • (1997) Exp Physiol , vol.82 , Issue.5 , pp. 871-886
    • Winding, B.1    Wiltink, A.2    Foged, N.T.3
  • 214
    • 0034728775 scopus 로고    scopus 로고
    • The inhibitory effects of vasoactive intestinal peptide and pituitary adenylate cyclase-activating polypeptide on osteoclast formation are associated with upregulation of osteoprotegerin and downregulation of RANKL and RANK
    • Mukohyama H, Ransjo M, Taniguchi H, Ohyama T, Lerner UH. The inhibitory effects of vasoactive intestinal peptide and pituitary adenylate cyclase-activating polypeptide on osteoclast formation are associated with upregulation of osteoprotegerin and downregulation of RANKL and RANK. Biochem Biophys Res Commun 2000;271(1):158–163.
    • (2000) Biochem Biophys Res Commun , vol.271 , Issue.1 , pp. 158-163
    • Mukohyama, H.1    Ransjo, M.2    Taniguchi, H.3    Ohyama, T.4    Lerner, U.H.5
  • 215
    • 71349087748 scopus 로고    scopus 로고
    • Changes of substance P during fracture healing in ovariectomized mice
    • Ding WG, Zhang ZM, Zhang YH, Jiang SD, Jiang LS, Dai LY. Changes of substance P during fracture healing in ovariectomized mice. Regul Pept 2010;159(1–3):28–34.
    • (2010) Regul Pept , vol.159 , Issue.1-3 , pp. 28-34
    • Ding, W.G.1    Zhang, Z.M.2    Zhang, Y.H.3    Jiang, S.D.4    Jiang, L.S.5    Dai, L.Y.6
  • 216
    • 4444312989 scopus 로고    scopus 로고
    • Substance P enhances the inhibition of osteoblastic cell differentiation induced by lipopolysaccharide from Porphyromonas gingivalis
    • Azuma H, Kido J, Ikedo D, Kataoka M, Nagata T. Substance P enhances the inhibition of osteoblastic cell differentiation induced by lipopolysaccharide from Porphyromonas gingivalis. J Periodontol 2004;75(7):974–981.
    • (2004) J Periodontol , vol.75 , Issue.7 , pp. 974-981
    • Azuma, H.1    Kido, J.2    Ikedo, D.3    Kataoka, M.4    Nagata, T.5
  • 217
    • 33846081607 scopus 로고    scopus 로고
    • Substance P stimulates late-stage rat osteoblastic bone formation through neurokinin-1 receptors
    • Goto T, Nakao K, Gunjigake KK, Kido MA, Kobayashi S, Tanaka T. Substance P stimulates late-stage rat osteoblastic bone formation through neurokinin-1 receptors. Neuropeptides 2007;41(1):25–31.
    • (2007) Neuropeptides , vol.41 , Issue.1 , pp. 25-31
    • Goto, T.1    Nakao, K.2    Gunjigake, K.K.3    Kido, M.A.4    Kobayashi, S.5    Tanaka, T.6
  • 218
    • 84898655709 scopus 로고    scopus 로고
    • Substance P activates the Wnt signal transduction pathway and enhances the differentiation of mouse preosteoblastic MC3T3-E1 cells
    • Mei G, Zou Z, Fu S, Xia L, Zhou J, Zhang Y, Tuo Y, Wang Z, Jin D. Substance P activates the Wnt signal transduction pathway and enhances the differentiation of mouse preosteoblastic MC3T3-E1 cells. Int J Mol Sci 2014;15(4):6224–6240.
    • (2014) Int J Mol Sci , vol.15 , Issue.4 , pp. 6224-6240
    • Mei, G.1    Zou, Z.2    Fu, S.3    Xia, L.4    Zhou, J.5    Zhang, Y.6    Tuo, Y.7    Wang, Z.8    Jin, D.9
  • 219
    • 84904113314 scopus 로고    scopus 로고
    • Neuropeptide substance P improves osteoblastic and angiogenic differentiation capacity of bone marrow stem cells in vitro
    • Fu S, Mei G, Wang Z, Zou Z-L, Liu S, Pei G-X, Bi L, Jin D. Neuropeptide substance P improves osteoblastic and angiogenic differentiation capacity of bone marrow stem cells in vitro. BioMed Res Int 2014;2014:10.
    • (2014) BioMed Res Int , vol.2014 , pp. 10
    • Fu, S.1    Mei, G.2    Wang, Z.3    Zou, Z.-L.4    Liu, S.5    Pei, G.-X.6    Bi, L.7    Jin, D.8
  • 220
    • 84935832425 scopus 로고    scopus 로고
    • Protective effect of neuropeptide substance P on bone marrow mesenchymal stem cells against apoptosis induced by serum deprivation
    • ;270328
    • Fu S, Jin D, Liu S, Wang L, Wang Z, Mei G, Zou ZL, Wu JQ, Xu ZY. Protective effect of neuropeptide substance P on bone marrow mesenchymal stem cells against apoptosis induced by serum deprivation. Stem Cells Int 2015;270328(10):28.
    • (2015) Stem Cells Int , Issue.10 , pp. 28
    • Fu, S.1    Jin, D.2    Liu, S.3    Wang, L.4    Wang, Z.5    Mei, G.6    Zou, Z.L.7    Wu, J.Q.8    Xu, Z.Y.9
  • 221
    • 0035041139 scopus 로고    scopus 로고
    • Effect of the neuropeptide substance P on the rat bone marrow-derived osteogenic cells in vitro
    • Adamus MA, Dabrowski ZJ. Effect of the neuropeptide substance P on the rat bone marrow-derived osteogenic cells in vitro. J Cell Biochem 2001;81(3):499–506.
    • (2001) J Cell Biochem , vol.81 , Issue.3 , pp. 499-506
    • Adamus, M.A.1    Dabrowski, Z.J.2
  • 222
    • 67649452522 scopus 로고    scopus 로고
    • Substance P stimulates bone marrow stromal cell osteogenic activity, osteoclast differentiation, and resorption activity in vitro
    • Wang L, Zhao R, Shi X, Wei T, Halloran BP, Clark DJ, Jacobs CR, Kingery WS. Substance P stimulates bone marrow stromal cell osteogenic activity, osteoclast differentiation, and resorption activity in vitro. Bone 2009;45(2):309–320.
    • (2009) Bone , vol.45 , Issue.2 , pp. 309-320
    • Wang, L.1    Zhao, R.2    Shi, X.3    Wei, T.4    Halloran, B.P.5    Clark, D.J.6    Jacobs, C.R.7    Kingery, W.S.8
  • 224
    • 84901365548 scopus 로고    scopus 로고
    • Long-term comparative study of substance-P with methylprednisolone on the development of osteoporosis
    • Hong HS, Um J, Lee ZH, Son Y. Long-term comparative study of substance-P with methylprednisolone on the development of osteoporosis. J Toxicol Sci 2014;39(3):391–399.
    • (2014) J Toxicol Sci , vol.39 , Issue.3 , pp. 391-399
    • Hong, H.S.1    Um, J.2    Lee, Z.H.3    Son, Y.4
  • 225
    • 84933520097 scopus 로고    scopus 로고
    • Evaluation of substance-P toxicity with single dose and repeated dose in rats
    • Hong H, Lim S, Son Y. Evaluation of substance-P toxicity with single dose and repeated dose in rats. Mol Cell Toxicol 2015;11(2):201–211.
    • (2015) Mol Cell Toxicol , vol.11 , Issue.2 , pp. 201-211
    • Hong, H.1    Lim, S.2    Son, Y.3
  • 226
    • 0026072470 scopus 로고
    • Human galanin: Molecular cloning reveals a unique structure
    • Evans HF, Shine J. Human galanin: Molecular cloning reveals a unique structure. Endocrinology 1991;129(3):1682–1684.
    • (1991) Endocrinology , vol.129 , Issue.3 , pp. 1682-1684
    • Evans, H.F.1    Shine, J.2
  • 230
    • 0029908859 scopus 로고    scopus 로고
    • Expression of galanin and a galanin receptor in several sensory systems and bone anlage of rat embryos
    • Xu ZQ, Shi TJ, Hokfelt T. Expression of galanin and a galanin receptor in several sensory systems and bone anlage of rat embryos. Proc Natl Acad Sci USA 1996;93(25):14901–14905.
    • (1996) Proc Natl Acad Sci USA , vol.93 , Issue.25 , pp. 14901-14905
    • Xu, Z.Q.1    Shi, T.J.2    Hokfelt, T.3
  • 231
    • 65549146880 scopus 로고    scopus 로고
    • Presence of galanin-like immunoreactivity in mesenchymal and neural crest origin tissues during embryonic development in the mouse
    • Jones M, Perumal P, Vrontakis M. Presence of galanin-like immunoreactivity in mesenchymal and neural crest origin tissues during embryonic development in the mouse. Anat Rec 2009;292(4):481–487.
    • (2009) Anat Rec , vol.292 , Issue.4 , pp. 481-487
    • Jones, M.1    Perumal, P.2    Vrontakis, M.3
  • 232
    • 0242708805 scopus 로고    scopus 로고
    • Expression of galanin and galanin receptor-1 in normal bone and during fracture repair in the rat
    • McDonald AC, Schuijers JA, Shen P-J, Gundlach AL, Grills BL. Expression of galanin and galanin receptor-1 in normal bone and during fracture repair in the rat. Bone 2003;33(5):788–797.
    • (2003) Bone , vol.33 , Issue.5 , pp. 788-797
    • McDonald, A.C.1    Schuijers, J.A.2    Shen, P.-J.3    Gundlach, A.L.4    Grills, B.L.5
  • 233
    • 33847746677 scopus 로고    scopus 로고
    • Galanin treatment offsets the inhibition of bone formation and downregulates the increase in mouse calvarial expression of TNFα and GalR2 mRNA induced by chronic daily injections of an injurious vehicle
    • McDonald A, Schuijers J, Gundlach A, Grills B. Galanin treatment offsets the inhibition of bone formation and downregulates the increase in mouse calvarial expression of TNFα and GalR2 mRNA induced by chronic daily injections of an injurious vehicle. Bone 2007;40(4):895–903.
    • (2007) Bone , vol.40 , Issue.4 , pp. 895-903
    • McDonald, A.1    Schuijers, J.2    Gundlach, A.3    Grills, B.4
  • 234
    • 79960942001 scopus 로고    scopus 로고
    • Connectomics of orexin-producing neurons: Interface of systems of emotion, energy homeostasis and arousal
    • Sakurai T, Mieda M. Connectomics of orexin-producing neurons: Interface of systems of emotion, energy homeostasis and arousal. Trends Pharmacol Sci 2011;32(8):451–462.
    • (2011) Trends Pharmacol Sci , vol.32 , Issue.8 , pp. 451-462
    • Sakurai, T.1    Mieda, M.2
  • 235
    • 33847121297 scopus 로고    scopus 로고
    • The neural circuit of orexin (hypocretin): Maintaining sleep and wakefulness
    • Sakurai T. The neural circuit of orexin (hypocretin): Maintaining sleep and wakefulness. Nat Rev Neurosci 2007;8(3):171–181.
    • (2007) Nat Rev Neurosci , vol.8 , Issue.3 , pp. 171-181
    • Sakurai, T.1
  • 236
    • 84902246937 scopus 로고    scopus 로고
    • Orexin regulates bone remodeling via a dominant positive central action and a subordinate negative peripheral action
    • Wei W, Motoike T, Krzeszinski JY, Jin Z, Xie XJ, Dechow PC, Yanagisawa M, Wan Y. Orexin regulates bone remodeling via a dominant positive central action and a subordinate negative peripheral action. Cell Metab 2014;19(6):927–940.
    • (2014) Cell Metab , vol.19 , Issue.6 , pp. 927-940
    • Wei, W.1    Motoike, T.2    Krzeszinski, J.Y.3    Jin, Z.4    Xie, X.J.5    Dechow, P.C.6    Yanagisawa, M.7    Wan, Y.8
  • 237
    • 65449131670 scopus 로고    scopus 로고
    • Orexin B inhibits proliferation and stimulates specialized function of cultured rat calvarial osteoblast-like cells
    • Ziolkowska A, Rucinski M, Tyczewska M, Malendowicz LK. Orexin B inhibits proliferation and stimulates specialized function of cultured rat calvarial osteoblast-like cells. Int J Mol Med 2008;22(6):749–755.
    • (2008) Int J Mol Med , vol.22 , Issue.6 , pp. 749-755
    • Ziolkowska, A.1    Rucinski, M.2    Tyczewska, M.3    Malendowicz, L.K.4
  • 238
    • 10744231748 scopus 로고    scopus 로고
    • Structure−activity studies of orexin A and orexin B at the human orexin 1 and orexin 2 receptors led to orexin 2 receptor selective and orexin 1 receptor preferring ligands
    • Lang M, Söll RM, Dürrenberger F, Dautzenberg FM, Beck-Sickinger AG. Structure−activity studies of orexin A and orexin B at the human orexin 1 and orexin 2 receptors led to orexin 2 receptor selective and orexin 1 receptor preferring ligands. J Med Chem 2004;47(5):1153–1160.
    • (2004) J Med Chem , vol.47 , Issue.5 , pp. 1153-1160
    • Lang, M.1    Söll, R.M.2    Dürrenberger, F.3    Dautzenberg, F.M.4    Beck-Sickinger, A.G.5
  • 239
    • 0029002165 scopus 로고
    • Cell-matrix interaction in bone: type I collagen modulates signal transduction in osteoblast-like cells
    • Green J, Schotland S, Stauber DJ, Kleeman CR, Clemens TL. Cell-matrix interaction in bone: type I collagen modulates signal transduction in osteoblast-like cells. Am J Physiol 1995;268(5 Pt 1):C1090–C1103.
    • (1995) Am J Physiol , vol.268 , Issue.5 , pp. C1090-C1103
    • Green, J.1    Schotland, S.2    Stauber, D.J.3    Kleeman, C.R.4    Clemens, T.L.5
  • 240
    • 8944223519 scopus 로고    scopus 로고
    • Enhanced cell attachment to anorganic bone mineral in the presence of a synthetic peptide related to collagen
    • Qian JJ, Bhatnagar RS. Enhanced cell attachment to anorganic bone mineral in the presence of a synthetic peptide related to collagen. J Biomed Mater Res 1996;31(4):545–554.
    • (1996) J Biomed Mater Res , vol.31 , Issue.4 , pp. 545-554
    • Qian, J.J.1    Bhatnagar, R.S.2
  • 241
    • 0032970565 scopus 로고    scopus 로고
    • Design of biomimetic habitats for tissue engineering with P-15, a synthetic peptide analogue of collagen
    • Bhatnagar RS, Qian JJ, Wedrychowska A, Sadeghi M, Wu YM, Smith N. Design of biomimetic habitats for tissue engineering with P-15, a synthetic peptide analogue of collagen. Tissue Eng 1999;5(1):53–65.
    • (1999) Tissue Eng , vol.5 , Issue.1 , pp. 53-65
    • Bhatnagar, R.S.1    Qian, J.J.2    Wedrychowska, A.3    Sadeghi, M.4    Wu, Y.M.5    Smith, N.6
  • 242
    • 0142059194 scopus 로고    scopus 로고
    • Enhanced cell attachment and osteoblastic activity by P-15 peptide-coated matrix in hydrogels
    • Nguyen H, Qian JJ, Bhatnagar RS, Li S. Enhanced cell attachment and osteoblastic activity by P-15 peptide-coated matrix in hydrogels. Biochem Biophys Res Commun 2003;311(1):179–186.
    • (2003) Biochem Biophys Res Commun , vol.311 , Issue.1 , pp. 179-186
    • Nguyen, H.1    Qian, J.J.2    Bhatnagar, R.S.3    Li, S.4
  • 244
    • 66149098935 scopus 로고    scopus 로고
    • Histomorphometric evaluation of natural mineral combined with a synthetic cell-binding peptide (P-15) in critical-size defects in the rat calvaria
    • Artzi Z, Kozlovsky A, Nemcovsky CE, Moses O, Tal H, Rohrer MD, Prasad HS, Weinreb M. Histomorphometric evaluation of natural mineral combined with a synthetic cell-binding peptide (P-15) in critical-size defects in the rat calvaria. Int J Oral Maxillofac Implants 2008;23(6):1063–1070.
    • (2008) Int J Oral Maxillofac Implants , vol.23 , Issue.6 , pp. 1063-1070
    • Artzi, Z.1    Kozlovsky, A.2    Nemcovsky, C.E.3    Moses, O.4    Tal, H.5    Rohrer, M.D.6    Prasad, H.S.7    Weinreb, M.8
  • 245
    • 24044438488 scopus 로고    scopus 로고
    • A study of biologically active peptide sequences (P-15) on the surface of an ABM scaffold (PepGen P-15) using AFM and FTIR
    • Hole BB, Schwarz JA, Gilbert JL, Atkinson BL. A study of biologically active peptide sequences (P-15) on the surface of an ABM scaffold (PepGen P-15) using AFM and FTIR. J Biomed Mater Res A 2005;74(4):712–721.
    • (2005) J Biomed Mater Res A , vol.74 , Issue.4 , pp. 712-721
    • Hole, B.B.1    Schwarz, J.A.2    Gilbert, J.L.3    Atkinson, B.L.4
  • 246
    • 34548444030 scopus 로고    scopus 로고
    • A comparative evaluation of the effectiveness of an anorganic bone matrix/cell binding peptide with an open flap debridement in human infrabony defects: A clinical and radiographic study
    • Bhongade ML, Tiwari IR. A comparative evaluation of the effectiveness of an anorganic bone matrix/cell binding peptide with an open flap debridement in human infrabony defects: A clinical and radiographic study. J Contemp Dent Pract 2007;8(6):25–34.
    • (2007) J Contemp Dent Pract , vol.8 , Issue.6 , pp. 25-34
    • Bhongade, M.L.1    Tiwari, I.R.2
  • 247
    • 33846787089 scopus 로고    scopus 로고
    • P-15 small peptide bone graft substitute in the treatment of non-unions and delayed union
    • A pilot clinical trial
    • Gomar F, Orozco R, Villar JL, Arrizabalaga F. P-15 small peptide bone graft substitute in the treatment of non-unions and delayed union. A pilot clinical trial. Int Orthop 2007;31(1):93–99.
    • (2007) Int Orthop , vol.31 , Issue.1 , pp. 93-99
    • Gomar, F.1    Orozco, R.2    Villar, J.L.3    Arrizabalaga, F.4
  • 248
    • 84945381784 scopus 로고    scopus 로고
    • Effects of P-15 peptide coated hydroxyapatite on tibial defect repair in vivo in normal and osteoporotic rats
    • Hestehave Pedersen R, Rasmussen M, Overgaard S, Ding M. Effects of P-15 peptide coated hydroxyapatite on tibial defect repair in vivo in normal and osteoporotic rats. BioMed Res Int 2015;2015:1–14.
    • (2015) BioMed Res Int , vol.2015 , pp. 1-14
    • Hestehave Pedersen, R.1    Rasmussen, M.2    Overgaard, S.3    Ding, M.4
  • 251
    • 0032087173 scopus 로고    scopus 로고
    • Multi-center clinical evaluation of combination anorganic bovine-derived hydroxyapatite matrix (ABM)/cell binding peptide (P-15) as a bone replacement graft material in human periodontal osseous defects. 6-Month results
    • Yukna RA, Callan DP, Krauser JT, Evans GH, Aichelmann-Reidy ME, Moore K, Cruz R, Scott JB. Multi-center clinical evaluation of combination anorganic bovine-derived hydroxyapatite matrix (ABM)/cell binding peptide (P-15) as a bone replacement graft material in human periodontal osseous defects. 6-Month results. J Periodontol 1998;69(6):655–663.
    • (1998) J Periodontol , vol.69 , Issue.6 , pp. 655-663
    • Yukna, R.A.1    Callan, D.P.2    Krauser, J.T.3    Evans, G.H.4    Aichelmann-Reidy, M.E.5    Moore, K.6    Cruz, R.7    Scott, J.B.8
  • 252
    • 84862966394 scopus 로고    scopus 로고
    • Biomimetic surface modification using synthetic oligopeptides for enhanced guided bone regeneration in beagles
    • Lee CK, Koo KT, Park YJ, Lee JY, Rhee SH, Ku Y, Rhyu IC, Chung CP. Biomimetic surface modification using synthetic oligopeptides for enhanced guided bone regeneration in beagles. J Periodontol 2012;83(1):101–110.
    • (2012) J Periodontol , vol.83 , Issue.1 , pp. 101-110
    • Lee, C.K.1    Koo, K.T.2    Park, Y.J.3    Lee, J.Y.4    Rhee, S.H.5    Ku, Y.6    Rhyu, I.C.7    Chung, C.P.8
  • 253
    • 41049112547 scopus 로고    scopus 로고
    • Immobilization of a bone and cartilage stimulating peptide to a synthetic bone graft
    • Wang V, Misra G, Amsden B. Immobilization of a bone and cartilage stimulating peptide to a synthetic bone graft. J Mater Sci Mater Med 2008;19(5):2145–2155.
    • (2008) J Mater Sci Mater Med , vol.19 , Issue.5 , pp. 2145-2155
    • Wang, V.1    Misra, G.2    Amsden, B.3
  • 254
    • 80053128154 scopus 로고    scopus 로고
    • Recruitment of progenitor cells by an extracellular matrix cryptic peptide in a mouse model of digit amputation
    • Agrawal V, Tottey S, Johnson SA, Freund JM, Siu BF, Badylak SF. Recruitment of progenitor cells by an extracellular matrix cryptic peptide in a mouse model of digit amputation. Tissue Eng 2011;17(19–20):2435–2443.
    • (2011) Tissue Eng , vol.17 , Issue.19-20 , pp. 2435-2443
    • Agrawal, V.1    Tottey, S.2    Johnson, S.A.3    Freund, J.M.4    Siu, B.F.5    Badylak, S.F.6
  • 255
    • 82355164089 scopus 로고    scopus 로고
    • An isolated cryptic peptide influences osteogenesis and bone remodeling in an adult mammalian model of digit amputation
    • Agrawal V, Kelly J, Tottey S, Daly KA, Johnson SA, Siu BF, Reing J, Badylak SF. An isolated cryptic peptide influences osteogenesis and bone remodeling in an adult mammalian model of digit amputation. Tissue Eng 2011;17(23–24):3033–3044.
    • (2011) Tissue Eng , vol.17 , Issue.23-24 , pp. 3033-3044
    • Agrawal, V.1    Kelly, J.2    Tottey, S.3    Daly, K.A.4    Johnson, S.A.5    Siu, B.F.6    Reing, J.7    Badylak, S.F.8
  • 256
    • 84875894563 scopus 로고    scopus 로고
    • Early gene and protein expression associated with osteoblast differentiation in response to fish collagen peptides powder
    • Yamada S, Yoshizawa Y, Kawakubo A, Ikeda T, Yanagiguchi K, Hayashi Y. Early gene and protein expression associated with osteoblast differentiation in response to fish collagen peptides powder. Dent Mater J 2013;32(2):233–240.
    • (2013) Dent Mater J , vol.32 , Issue.2 , pp. 233-240
    • Yamada, S.1    Yoshizawa, Y.2    Kawakubo, A.3    Ikeda, T.4    Yanagiguchi, K.5    Hayashi, Y.6
  • 257
    • 0025823208 scopus 로고
    • Identification of a tetrapeptide recognition sequence for the alpha 2 beta 1 integrin in collagen
    • Staatz WD, Fok KF, Zutter MM, Adams SP, Rodriguez BA, Santoro SA. Identification of a tetrapeptide recognition sequence for the alpha 2 beta 1 integrin in collagen. J Biol Chem 1991;266(12):7363–7367.
    • (1991) J Biol Chem , vol.266 , Issue.12 , pp. 7363-7367
    • Staatz, W.D.1    Fok, K.F.2    Zutter, M.M.3    Adams, S.P.4    Rodriguez, B.A.5    Santoro, S.A.6
  • 258
    • 79953882460 scopus 로고    scopus 로고
    • Early osteogenic differentiation of mouse preosteoblasts induced by collagen-derived DGEA-peptide on nanofibrous phage tissue matrices
    • Yoo SY, Kobayashi M, Lee PP, Lee S-W. Early osteogenic differentiation of mouse preosteoblasts induced by collagen-derived DGEA-peptide on nanofibrous phage tissue matrices. Biomacromolecules 2011;12(4):987–996.
    • (2011) Biomacromolecules , vol.12 , Issue.4 , pp. 987-996
    • Yoo, S.Y.1    Kobayashi, M.2    Lee, P.P.3    Lee, S.-W.4
  • 259
    • 59649101082 scopus 로고    scopus 로고
    • The effect of collagen I mimetic peptides on mesenchymal stem cell adhesion and differentiation, and on bone formation at hydroxyapatite surfaces
    • Hennessy KM, Pollot BE, Clem WC, Phipps MC, Sawyer AA, Culpepper BK, Bellis SL. The effect of collagen I mimetic peptides on mesenchymal stem cell adhesion and differentiation, and on bone formation at hydroxyapatite surfaces. Biomaterials 2009;30(10):1898–1909.
    • (2009) Biomaterials , vol.30 , Issue.10 , pp. 1898-1909
    • Hennessy, K.M.1    Pollot, B.E.2    Clem, W.C.3    Phipps, M.C.4    Sawyer, A.A.5    Culpepper, B.K.6    Bellis, S.L.7
  • 260
    • 84974695929 scopus 로고    scopus 로고
    • The collagen I mimetic peptide DGEA enhances an osteogenic phenotype in mesenchymal stem cells when presented from cell-encapsulating hydrogels
    • Mehta M, Madl CM, Lee S, Duda GN, Mooney DJ. The collagen I mimetic peptide DGEA enhances an osteogenic phenotype in mesenchymal stem cells when presented from cell-encapsulating hydrogels. J Biomed Mater Res A 2015;8(10):35497.
    • (2015) J Biomed Mater Res A , vol.8 , Issue.10 , pp. 35497
    • Mehta, M.1    Madl, C.M.2    Lee, S.3    Duda, G.N.4    Mooney, D.J.5
  • 265
  • 266
    • 84907264996 scopus 로고    scopus 로고
    • Selective osteogenesis by a synthetic mineral inducing peptide for the treatment of osteoporosis
    • Park YS, Lee JY, Suh JS, Jin YM, Yu Y, Kim HY, Park YJ, Chung CP, Jo I. Selective osteogenesis by a synthetic mineral inducing peptide for the treatment of osteoporosis. Biomaterials 2014;35(37):9747–9754.
    • (2014) Biomaterials , vol.35 , Issue.37 , pp. 9747-9754
    • Park, Y.S.1    Lee, J.Y.2    Suh, J.S.3    Jin, Y.M.4    Yu, Y.5    Kim, H.Y.6    Park, Y.J.7    Chung, C.P.8    Jo, I.9
  • 267
    • 0242438787 scopus 로고    scopus 로고
    • Attachment, proliferation, and migration of marrow stromal osteoblasts cultured on biomimetic hydrogels modified with an osteopontin-derived peptide
    • Shin H, Zygourakis K, Farach-Carson MC, Yaszemski MJ, Mikos AG. Attachment, proliferation, and migration of marrow stromal osteoblasts cultured on biomimetic hydrogels modified with an osteopontin-derived peptide. Biomaterials 2004;25(5):895–906.
    • (2004) Biomaterials , vol.25 , Issue.5 , pp. 895-906
    • Shin, H.1    Zygourakis, K.2    Farach-Carson, M.C.3    Yaszemski, M.J.4    Mikos, A.G.5
  • 268
    • 84872683473 scopus 로고    scopus 로고
    • Enhanced osteogenesis by collagen-binding peptide from bone sialoprotein in vitro and in vivo
    • Choi YJ, Lee JY, Chung C-P, Park YJ. Enhanced osteogenesis by collagen-binding peptide from bone sialoprotein in vitro and in vivo. J Biomed Mater Res 2013;101A(2):547–554.
    • (2013) J Biomed Mater Res , vol.101A , Issue.2 , pp. 547-554
    • Choi, Y.J.1    Lee, J.Y.2    Chung, C.-P.3    Park, Y.J.4
  • 269
    • 84876756847 scopus 로고    scopus 로고
    • Targeting integrins to promote bone formation and repair
    • Marie PJ. Targeting integrins to promote bone formation and repair. Nat Rev Endocrinol 2013;9(5):288–295.
    • (2013) Nat Rev Endocrinol , vol.9 , Issue.5 , pp. 288-295
    • Marie, P.J.1
  • 270
    • 84856895642 scopus 로고    scopus 로고
    • Lentiviral-mediated integrin alpha5 expression in human adult mesenchymal stromal cells promotes bone repair in mouse cranial and long-bone defects
    • Srouji S, Ben-David D, Fromigue O, Vaudin P, Kuhn G, Muller R, Livne E, Marie PJ. Lentiviral-mediated integrin alpha5 expression in human adult mesenchymal stromal cells promotes bone repair in mouse cranial and long-bone defects. Hum Gene Ther 2012;23(2):167–172.
    • (2012) Hum Gene Ther , vol.23 , Issue.2 , pp. 167-172
    • Srouji, S.1    Ben-David, D.2    Fromigue, O.3    Vaudin, P.4    Kuhn, G.5    Muller, R.6    Livne, E.7    Marie, P.J.8
  • 271
    • 77953704786 scopus 로고    scopus 로고
    • Crosstalks between integrin alpha 5 and IGF2/IGFBP2 signalling trigger human bone marrow-derived mesenchymal stromal osteogenic differentiation
    • Hamidouche Z, Fromigue O, Ringe J, Haupl T, Marie PJ. Crosstalks between integrin alpha 5 and IGF2/IGFBP2 signalling trigger human bone marrow-derived mesenchymal stromal osteogenic differentiation. BMC Cell Biol 2010;11(44):1471–2121.
    • (2010) BMC Cell Biol , vol.11 , Issue.44 , pp. 1471-2121
    • Hamidouche, Z.1    Fromigue, O.2    Ringe, J.3    Haupl, T.4    Marie, P.J.5
  • 273
    • 0034617217 scopus 로고    scopus 로고
    • Molecular basis of ligand recognition by integrin alpha 5beta 1. I. Specificity of ligand binding is determined by amino acid sequences in the second and third NH2-terminal repeats of the alpha subunit
    • Mould AP, Askari JA, Humphries MJ. Molecular basis of ligand recognition by integrin alpha 5beta 1. I. Specificity of ligand binding is determined by amino acid sequences in the second and third NH2-terminal repeats of the alpha subunit. J Biol Chem 2000;275(27):20324–20336.
    • (2000) J Biol Chem , vol.275 , Issue.27 , pp. 20324-20336
    • Mould, A.P.1    Askari, J.A.2    Humphries, M.J.3
  • 274
    • 0027976103 scopus 로고
    • Isolation of a highly specific ligand for the alpha 5 beta 1 integrin from a phage display library
    • Koivunen E, Wang B, Ruoslahti E. Isolation of a highly specific ligand for the alpha 5 beta 1 integrin from a phage display library. J Cell Biol 1994;124(3):373–380.
    • (1994) J Cell Biol , vol.124 , Issue.3 , pp. 373-380
    • Koivunen, E.1    Wang, B.2    Ruoslahti, E.3
  • 276
    • 84924911742 scopus 로고    scopus 로고
    • Wnt-β-catenin signaling mediates osteoblast differentiation triggered by peptide-induced α5β1 integrin priming in mesenchymal skeletal cells
    • Saidak Z, Le Henaff C, Azzi S, Marty C, Da Nascimento S, Sonnet P, Marie PJ. Wnt-β-catenin signaling mediates osteoblast differentiation triggered by peptide-induced α5β1 integrin priming in mesenchymal skeletal cells. J Biol Chem 2015;290(11):6903–6912.
    • (2015) J Biol Chem , vol.290 , Issue.11 , pp. 6903-6912
    • Saidak, Z.1    Le Henaff, C.2    Azzi, S.3    Marty, C.4    Da Nascimento, S.5    Sonnet, P.6    Marie, P.J.7
  • 277
    • 84893258445 scopus 로고    scopus 로고
    • Osteogenic differentiation of human mesenchymal stem cells on alpha5 integrin binding peptide hydrogels is dependent on substrate elasticity
    • Gandavarapu NR, Alge DL, Anseth KS. Osteogenic differentiation of human mesenchymal stem cells on alpha5 integrin binding peptide hydrogels is dependent on substrate elasticity. Biomater Sci 2014;2(3):352–361.
    • (2014) Biomater Sci , vol.2 , Issue.3 , pp. 352-361
    • Gandavarapu, N.R.1    Alge, D.L.2    Anseth, K.S.3
  • 278
    • 84865799908 scopus 로고    scopus 로고
    • Tailored integrin-extracellular matrix interactions to direct human mesenchymal stem cell differentiation
    • Frith JE, Mills RJ, Hudson JE, Cooper-White JJ. Tailored integrin-extracellular matrix interactions to direct human mesenchymal stem cell differentiation. Stem Cells Dev 2012;21(13):2442–2456.
    • (2012) Stem Cells Dev , vol.21 , Issue.13 , pp. 2442-2456
    • Frith, J.E.1    Mills, R.J.2    Hudson, J.E.3    Cooper-White, J.J.4
  • 279
    • 49149124472 scopus 로고    scopus 로고
    • ASARM-truncated MEPE and AC-100 enhance osteogenesis by promoting osteoprogenitor adhesion
    • Sprowson AP, McCaskie AW, Birch MA. ASARM-truncated MEPE and AC-100 enhance osteogenesis by promoting osteoprogenitor adhesion. J Orthop Res 2008;26(9):1256–1262.
    • (2008) J Orthop Res , vol.26 , Issue.9 , pp. 1256-1262
    • Sprowson, A.P.1    McCaskie, A.W.2    Birch, M.A.3
  • 282
  • 283
    • 21644453949 scopus 로고    scopus 로고
    • A fragment of the hypophosphatemic factor, MEPE, requires inducible cyclooxygenase-2 to exert potent anabolic effects on normal human marrow osteoblast precursors
    • Nagel DE, Khosla S, Sanyal A, Rosen DM, Kumagai Y, Riggs BL. A fragment of the hypophosphatemic factor, MEPE, requires inducible cyclooxygenase-2 to exert potent anabolic effects on normal human marrow osteoblast precursors. J Cell Biochem 2004;93(6):1107–1114.
    • (2004) J Cell Biochem , vol.93 , Issue.6 , pp. 1107-1114
    • Nagel, D.E.1    Khosla, S.2    Sanyal, A.3    Rosen, D.M.4    Kumagai, Y.5    Riggs, B.L.6
  • 284
    • 81355138197 scopus 로고    scopus 로고
    • Cooperative effects in differentiation and proliferation between PDGF-BB and matrix derived synthetic peptides in human osteoblasts
    • Vordemvenne T, Paletta J, Hartensuer R, Pap T, Raschke M, Ochman S. Cooperative effects in differentiation and proliferation between PDGF-BB and matrix derived synthetic peptides in human osteoblasts. BMC Musculoskel Dis 2011;12(263):1–7.
    • (2011) BMC Musculoskel Dis , vol.12 , Issue.263 , pp. 1-7
    • Vordemvenne, T.1    Paletta, J.2    Hartensuer, R.3    Pap, T.4    Raschke, M.5    Ochman, S.6
  • 285
    • 3042778752 scopus 로고    scopus 로고
    • Dentonin, a fragment of MEPE, enhanced dental pulp stem cell proliferation
    • Liu H, Li W, Gao C, Kumagai Y, Blacher RW, DenBesten PK. Dentonin, a fragment of MEPE, enhanced dental pulp stem cell proliferation. J Dent Res 2004;83(6):496–499.
    • (2004) J Dent Res , vol.83 , Issue.6 , pp. 496-499
    • Liu, H.1    Li, W.2    Gao, C.3    Kumagai, Y.4    Blacher, R.W.5    DenBesten, P.K.6
  • 286
    • 84862815084 scopus 로고    scopus 로고
    • Surface immobilization of MEPE peptide onto HA/β-TCP ceramic particles enhances bone regeneration and remodeling
    • Acharya B, Chun S-Y, Kim S-Y, Moon C, Shin H-I, Park EK. Surface immobilization of MEPE peptide onto HA/β-TCP ceramic particles enhances bone regeneration and remodeling. J Biomed Mater Res Part B Appl Biomater 2012;100B(3):841–849.
    • (2012) J Biomed Mater Res Part B Appl Biomater , vol.100B , Issue.3 , pp. 841-849
    • Acharya, B.1    Chun, S.-Y.2    Kim, S.-Y.3    Moon, C.4    Shin, H.-I.5    Park, E.K.6
  • 287
    • 0029798147 scopus 로고    scopus 로고
    • Cloning and characterization of an IGF-1 isoform expressed in skeletal muscle subjected to stretch
    • Yang S, Alnaqeeb M, Simpson H, Goldspink G. Cloning and characterization of an IGF-1 isoform expressed in skeletal muscle subjected to stretch. J Muscle Res Cell Motil 1996;17(4):487–495.
    • (1996) J Muscle Res Cell Motil , vol.17 , Issue.4 , pp. 487-495
    • Yang, S.1    Alnaqeeb, M.2    Simpson, H.3    Goldspink, G.4
  • 288
    • 24044511547 scopus 로고    scopus 로고
    • Mechanical signals, IGF-I gene splicing, and muscle adaptation
    • Goldspink G. Mechanical signals, IGF-I gene splicing, and muscle adaptation. Physiology 2005;20:232–238.
    • (2005) Physiology , vol.20 , pp. 232-238
    • Goldspink, G.1
  • 289
    • 0033560860 scopus 로고    scopus 로고
    • Expression of insulin growth factor-1 splice variants and structural genes in rabbit skeletal muscle induced by stretch and stimulation
    • McKoy G, Ashley W, Mander J, Yang SY, Williams N, Russell B, Goldspink G. Expression of insulin growth factor-1 splice variants and structural genes in rabbit skeletal muscle induced by stretch and stimulation. J Physiol 1999;516(Pt 2):583–592.
    • (1999) J Physiol , vol.516 , pp. 583-592
    • McKoy, G.1    Ashley, W.2    Mander, J.3    Yang, S.Y.4    Williams, N.5    Russell, B.6    Goldspink, G.7
  • 290
    • 0038385981 scopus 로고    scopus 로고
    • Expression and splicing of the insulin-like growth factor gene in rodent muscle is associated with muscle satellite (stem) cell activation following local tissue damage
    • Hill M, Goldspink G. Expression and splicing of the insulin-like growth factor gene in rodent muscle is associated with muscle satellite (stem) cell activation following local tissue damage. J Physiol 2003;549(Pt 2):409–418.
    • (2003) J Physiol , vol.549 , pp. 409-418
    • Hill, M.1    Goldspink, G.2
  • 291
    • 77955427566 scopus 로고    scopus 로고
    • IGF-IEc expression, regulation and biological function in different tissues
    • Dai Z, Wu F, Yeung EW, Li Y. IGF-IEc expression, regulation and biological function in different tissues. Growth Horm IGF Res 2010;20(4):275–281.
    • (2010) Growth Horm IGF Res , vol.20 , Issue.4 , pp. 275-281
    • Dai, Z.1    Wu, F.2    Yeung, E.W.3    Li, Y.4
  • 292
    • 84865628351 scopus 로고    scopus 로고
    • The nuclear localization of MGF receptor in osteoblasts under mechanical stimulation
    • Peng Q, Qiu J, Sun J, Yang L, Zhang B, Wang Y. The nuclear localization of MGF receptor in osteoblasts under mechanical stimulation. Mol Cell Biochem 2012;369(1–2):147–156.
    • (2012) Mol Cell Biochem , vol.369 , Issue.1-2 , pp. 147-156
    • Peng, Q.1    Qiu, J.2    Sun, J.3    Yang, L.4    Zhang, B.5    Wang, Y.6
  • 293
    • 79961173310 scopus 로고    scopus 로고
    • Mechano growth factor E peptide promotes osteoblasts proliferation and bone-defect healing in rabbits
    • Deng M, Zhang B, Wang K, Liu F, Xiao H, Zhao J, Liu P, Li Y, Lin F, Wang Y. Mechano growth factor E peptide promotes osteoblasts proliferation and bone-defect healing in rabbits. Int Orthop 2011;35(7):1099–1106.
    • (2011) Int Orthop , vol.35 , Issue.7 , pp. 1099-1106
    • Deng, M.1    Zhang, B.2    Wang, K.3    Liu, F.4    Xiao, H.5    Zhao, J.6    Liu, P.7    Li, Y.8    Lin, F.9    Wang, Y.10
  • 294
    • 84861635694 scopus 로고    scopus 로고
    • Mechano-growth factor E peptide inhibits the differentiation and mineralization of osteoblasts
    • Xin C, Bingbing Z, Yuanliang W, Chengyu X, Li Y, Moyuan D, Qin P, Yuxiao L. Mechano-growth factor E peptide inhibits the differentiation and mineralization of osteoblasts. Arch Oral Biol 2012;57(6):720–727.
    • (2012) Arch Oral Biol , vol.57 , Issue.6 , pp. 720-727
    • Xin, C.1    Bingbing, Z.2    Yuanliang, W.3    Chengyu, X.4    Li, Y.5    Moyuan, D.6    Qin, P.7    Yuxiao, L.8
  • 295
    • 84898746988 scopus 로고    scopus 로고
    • In vitro cytocompatibility evaluation of MGF-Ct24E chemically grafted and physically blended with maleic anhydride modified poly(D, L-lactic acid)
    • Li Y, Wang Y, Wang P, Zhang B, Yan W, Sun J, Pan J. In vitro cytocompatibility evaluation of MGF-Ct24E chemically grafted and physically blended with maleic anhydride modified poly(D, L-lactic acid). J Biomater Sci Polym Ed 2013;24(7):849–864.
    • (2013) J Biomater Sci Polym Ed , vol.24 , Issue.7 , pp. 849-864
    • Li, Y.1    Wang, Y.2    Wang, P.3    Zhang, B.4    Yan, W.5    Sun, J.6    Pan, J.7
  • 296
    • 84893975930 scopus 로고    scopus 로고
    • Mechano growth factor E peptide regulates migration and differentiation of bone marrow mesenchymal stem cells
    • Cui H, Yi Q, Feng J, Yang L, Tang L. Mechano growth factor E peptide regulates migration and differentiation of bone marrow mesenchymal stem cells. J Mol Endocrinol 2014;52(2):111–120.
    • (2014) J Mol Endocrinol , vol.52 , Issue.2 , pp. 111-120
    • Cui, H.1    Yi, Q.2    Feng, J.3    Yang, L.4    Tang, L.5
  • 297
    • 84899435674 scopus 로고    scopus 로고
    • Functional and transcriptomic analysis of the regulation of osteoblasts by mechano-growth factor E peptide
    • Xin J, Wang Y, Wang Z, Lin F. Functional and transcriptomic analysis of the regulation of osteoblasts by mechano-growth factor E peptide. Biotechnol Appl Biochem 2014;61(2):193–201.
    • (2014) Biotechnol Appl Biochem , vol.61 , Issue.2 , pp. 193-201
    • Xin, J.1    Wang, Y.2    Wang, Z.3    Lin, F.4
  • 298
    • 84940447142 scopus 로고    scopus 로고
    • Improving the osteogenic efficacy of BMP2 with mechano growth factor by regulating the signaling events in BMP pathway
    • Deng M, Liu P, Xiao H, Zhang Y, Wang Y, Zhao J, Xu J. Improving the osteogenic efficacy of BMP2 with mechano growth factor by regulating the signaling events in BMP pathway. Cell Tissue Res 2015;361(3):723–731.
    • (2015) Cell Tissue Res , vol.361 , Issue.3 , pp. 723-731
    • Deng, M.1    Liu, P.2    Xiao, H.3    Zhang, Y.4    Wang, Y.5    Zhao, J.6    Xu, J.7
  • 304
    • 33846805814 scopus 로고    scopus 로고
    • Apelin stimulates proliferation and suppresses apoptosis of mouse osteoblastic cell line MC3T3-E1 via JNK and PI3-K/Akt signaling pathways
    • Tang S-Y, Xie H, Yuan L-Q, Luo X-H, Huang J, Cui R-R, Zhou H-D, Wu X-P, Liao E-Y. Apelin stimulates proliferation and suppresses apoptosis of mouse osteoblastic cell line MC3T3-E1 via JNK and PI3-K/Akt signaling pathways. Peptides 2007;28(3):708–718.
    • (2007) Peptides , vol.28 , Issue.3 , pp. 708-718
    • Tang, S.-Y.1    Xie, H.2    Yuan, L.-Q.3    Luo, X.-H.4    Huang, J.5    Cui, R.-R.6    Zhou, H.-D.7    Wu, X.-P.8    Liao, E.-Y.9
  • 305
    • 77954338033 scopus 로고    scopus 로고
    • Relationships between serum adiponectin, apelin, leptin, resistin, visfatin levels and bone mineral density, and bone biochemical markers in post-menopausal Chinese women
    • Zhang H, Xie H, Zhao Q, Xie GQ, Wu XP, Liao EY, Luo XH. Relationships between serum adiponectin, apelin, leptin, resistin, visfatin levels and bone mineral density, and bone biochemical markers in post-menopausal Chinese women. J Endocrinol Invest 2010;33(10):707–711.
    • (2010) J Endocrinol Invest , vol.33 , Issue.10 , pp. 707-711
    • Zhang, H.1    Xie, H.2    Zhao, Q.3    Xie, G.Q.4    Wu, X.P.5    Liao, E.Y.6    Luo, X.H.7
  • 307
    • 84856202713 scopus 로고    scopus 로고
    • Protective effect of apelin on cultured rat bone marrow mesenchymal stem cells against apoptosis
    • Zeng X, Yu SP, Taylor T, Ogle M, Wei L. Protective effect of apelin on cultured rat bone marrow mesenchymal stem cells against apoptosis. Stem Cell Res 2012;8(3):357–367.
    • (2012) Stem Cell Res , vol.8 , Issue.3 , pp. 357-367
    • Zeng, X.1    Yu, S.P.2    Taylor, T.3    Ogle, M.4    Wei, L.5
  • 308
    • 84862809553 scopus 로고    scopus 로고
    • New cyclic peptides with osteoblastic proliferative activity from Dianthus superbus
    • Tong Y, Luo JG, Wang R, Wang XB, Kong LY. New cyclic peptides with osteoblastic proliferative activity from Dianthus superbus. Bioorg Med Chem Lett 2012;22(5):1908–1911.
    • (2012) Bioorg Med Chem Lett , vol.22 , Issue.5 , pp. 1908-1911
    • Tong, Y.1    Luo, J.G.2    Wang, R.3    Wang, X.B.4    Kong, L.Y.5
  • 309
    • 84907930424 scopus 로고    scopus 로고
    • Synthesis and biological evaluation of the osteoblast proliferating cyclic peptides dianthins G and H
    • Kaur H, Heapy AM, Kowalczyk R, Amso Z, Watson M, Cornish J, Brimble MA. Synthesis and biological evaluation of the osteoblast proliferating cyclic peptides dianthins G and H. Tetrahedron 2014;70(42):7788–7794.
    • (2014) Tetrahedron , vol.70 , Issue.42 , pp. 7788-7794
    • Kaur, H.1    Heapy, A.M.2    Kowalczyk, R.3    Amso, Z.4    Watson, M.5    Cornish, J.6    Brimble, M.A.7
  • 310
    • 0026552958 scopus 로고
    • Histone H4-related osteogenic growth peptide (OGP): A novel circulating stimulator of osteoblastic activity
    • Bab I, Gazit D, Chorev M, Muhlrad A, Shteyer A, Greenberg Z, Namdar M, Kahn A. Histone H4-related osteogenic growth peptide (OGP): A novel circulating stimulator of osteoblastic activity. EMBO J 1992;11(5):1867–1873.
    • (1992) EMBO J , vol.11 , Issue.5 , pp. 1867-1873
    • Bab, I.1    Gazit, D.2    Chorev, M.3    Muhlrad, A.4    Shteyer, A.5    Greenberg, Z.6    Namdar, M.7    Kahn, A.8
  • 315
    • 0034017168 scopus 로고    scopus 로고
    • Osteogenic growth peptide normally stimulated by blood loss and marrow ablation has local and systemic effects on fracture healing in rats
    • Brager MA, Patterson MJ, Connolly JF, Nevo Z. Osteogenic growth peptide normally stimulated by blood loss and marrow ablation has local and systemic effects on fracture healing in rats. J Orthop Res 2000;18(1):133–139.
    • (2000) J Orthop Res , vol.18 , Issue.1 , pp. 133-139
    • Brager, M.A.1    Patterson, M.J.2    Connolly, J.F.3    Nevo, Z.4
  • 316
    • 0032056318 scopus 로고    scopus 로고
    • Osteogenic growth peptide enhances the rate of fracture healing in rabbits
    • Sun YQ, Ashhurst DE. Osteogenic growth peptide enhances the rate of fracture healing in rabbits. Cell Biol Int 1998;22(4):313–319.
    • (1998) Cell Biol Int , vol.22 , Issue.4 , pp. 313-319
    • Sun, Y.Q.1    Ashhurst, D.E.2
  • 317
    • 2942739131 scopus 로고    scopus 로고
    • Osteogenic growth peptide modulates fracture callus structural and mechanical properties
    • Gabet Y, Muller R, Regev E, Sela J, Shteyer A, Salisbury K, Chorev M, Bab I. Osteogenic growth peptide modulates fracture callus structural and mechanical properties. Bone 2004;35(1):65–73.
    • (2004) Bone , vol.35 , Issue.1 , pp. 65-73
    • Gabet, Y.1    Muller, R.2    Regev, E.3    Sela, J.4    Shteyer, A.5    Salisbury, K.6    Chorev, M.7    Bab, I.8
  • 318
    • 79955645757 scopus 로고    scopus 로고
    • Osteogenic growth peptide accelerates bone healing during distraction osteogenesis in rabbit tibia
    • Zhao Z-Y, Shao L, Zhao H-M, Zhong Z-H, Liu J-Y, Hao C-G. Osteogenic growth peptide accelerates bone healing during distraction osteogenesis in rabbit tibia. J Int Med Res 2011;39(2):456–463.
    • (2011) J Int Med Res , vol.39 , Issue.2 , pp. 456-463
    • Zhao, Z.-Y.1    Shao, L.2    Zhao, H.-M.3    Zhong, Z.-H.4    Liu, J.-Y.5    Hao, C.-G.6
  • 320
    • 36249032275 scopus 로고    scopus 로고
    • Biological designer self-assembling peptide nanofiber scaffolds significantly enhance osteoblast proliferation, differentiation and 3-D migration
    • Horii A, Wang X, Gelain F, Zhang S. Biological designer self-assembling peptide nanofiber scaffolds significantly enhance osteoblast proliferation, differentiation and 3-D migration. PLoS One 2007;2(2):e190.
    • (2007) PLoS One , vol.2 , Issue.2
    • Horii, A.1    Wang, X.2    Gelain, F.3    Zhang, S.4
  • 321
    • 55249116277 scopus 로고    scopus 로고
    • Osteogenic growth peptide incorporated into PLGA scaffolds accelerates healing of segmental long bone defects in rabbits
    • Shuqiang M, Kunzheng W, Xiaoqiang D, Wei W, Mingyu Z, Daocheng W. Osteogenic growth peptide incorporated into PLGA scaffolds accelerates healing of segmental long bone defects in rabbits. J Plast Reconstr Aesthet Surg 2008;61(12):1558–1560.
    • (2008) J Plast Reconstr Aesthet Surg , vol.61 , Issue.12 , pp. 1558-1560
    • Shuqiang, M.1    Kunzheng, W.2    Xiaoqiang, D.3    Wei, W.4    Mingyu, Z.5    Daocheng, W.6
  • 322
    • 54349110111 scopus 로고    scopus 로고
    • Osteogenic actions of the osteogenic growth peptide on bovine marrow mesenchymal stromal cells in culture
    • Zhu HB, Guo DZ, Yang SJ, Zhang YH, Wang H, Guo HT, Zhang Y, Cheng DC. Osteogenic actions of the osteogenic growth peptide on bovine marrow mesenchymal stromal cells in culture. Vet Med 2008;53(9):501–509.
    • (2008) Vet Med , vol.53 , Issue.9 , pp. 501-509
    • Zhu, H.B.1    Guo, D.Z.2    Yang, S.J.3    Zhang, Y.H.4    Wang, H.5    Guo, H.T.6    Zhang, Y.7    Cheng, D.C.8
  • 323
    • 0028920686 scopus 로고
    • Osteogenic growth peptide regulates proliferation and osteogenic maturation of human and rabbit bone marrow stromal cells
    • Robinson D, Bab I, Nevo Z. Osteogenic growth peptide regulates proliferation and osteogenic maturation of human and rabbit bone marrow stromal cells. J Bone Miner Res 1995;10(5):690–696.
    • (1995) J Bone Miner Res , vol.10 , Issue.5 , pp. 690-696
    • Robinson, D.1    Bab, I.2    Nevo, Z.3
  • 324
    • 78049473824 scopus 로고    scopus 로고
    • Osteogenic growth peptide enhances the proliferation of bone marrow mesenchymal stem cells from osteoprotegerin-deficient mice by CDK2/cyclin A
    • Fei Q, Guo C, Xu X, Gao J, Zhang J, Chen T, Cui D. Osteogenic growth peptide enhances the proliferation of bone marrow mesenchymal stem cells from osteoprotegerin-deficient mice by CDK2/cyclin A. Acta Biochim Biophys Sin 2010;42(11):801–806.
    • (2010) Acta Biochim Biophys Sin , vol.42 , Issue.11 , pp. 801-806
    • Fei, Q.1    Guo, C.2    Xu, X.3    Gao, J.4    Zhang, J.5    Chen, T.6    Cui, D.7
  • 325
    • 84879792131 scopus 로고    scopus 로고
    • Synthetic osteogenic growth peptide promotes differentiation of human bone marrow mesenchymal stem cells to osteoblasts via RhoA/ROCK pathway
    • Chen Z, Wang X, Shao Y, Shi D, Chen T, Cui D, Jiang X. Synthetic osteogenic growth peptide promotes differentiation of human bone marrow mesenchymal stem cells to osteoblasts via RhoA/ROCK pathway. Mol Cell Biochem 2011;358(1–2):221–227.
    • (2011) Mol Cell Biochem , vol.358 , Issue.1-2 , pp. 221-227
    • Chen, Z.1    Wang, X.2    Shao, Y.3    Shi, D.4    Chen, T.5    Cui, D.6    Jiang, X.7
  • 326
    • 0027199614 scopus 로고
    • Mitogenic action of osteogenic growth peptide (OGP): role of amino and carboxy-terminal regions and charge
    • Greenberg Z, Chorev M, Muhlrad A, Shteyer A, Namdar M, Mansur N, Bab I. Mitogenic action of osteogenic growth peptide (OGP): role of amino and carboxy-terminal regions and charge. Biochim Biophys Acta 1993;1178(3):273–280.
    • (1993) Biochim Biophys Acta , vol.1178 , Issue.3 , pp. 273-280
    • Greenberg, Z.1    Chorev, M.2    Muhlrad, A.3    Shteyer, A.4    Namdar, M.5    Mansur, N.6    Bab, I.7
  • 327
    • 0035011082 scopus 로고    scopus 로고
    • Mitogenic Gi protein-MAP kinase signaling cascade in MC3T3-E1 osteogenic cells: Activation by C-terminal pentapeptide of osteogenic growth peptide [OGP(10–14)] and attenuation of activation by cAMP
    • Gabarin N, Gavish H, Muhlrad A, Chen Y-C, Namdar-Attar M, Nissenson RA, Chorev M, Bab I. Mitogenic Gi protein-MAP kinase signaling cascade in MC3T3-E1 osteogenic cells: Activation by C-terminal pentapeptide of osteogenic growth peptide [OGP(10–14)] and attenuation of activation by cAMP. J Cell Biochem 2001;81(4):594–603.
    • (2001) J Cell Biochem , vol.81 , Issue.4 , pp. 594-603
    • Gabarin, N.1    Gavish, H.2    Muhlrad, A.3    Chen, Y.-C.4    Namdar-Attar, M.5    Nissenson, R.A.6    Chorev, M.7    Bab, I.8
  • 329
    • 34248591018 scopus 로고    scopus 로고
    • Osteogenic growth peptide C-terminal pentapeptide [OGP(10–14)] acts on rat bone marrow mesenchymal stem cells to promote differentiation to osteoblasts and to inhibit differentiation to adipocytes
    • Chen Z-X, Chang M, Peng Y-L, Zhao L, Zhan Y-R, Wang L-J, Wang R. Osteogenic growth peptide C-terminal pentapeptide [OGP(10–14)] acts on rat bone marrow mesenchymal stem cells to promote differentiation to osteoblasts and to inhibit differentiation to adipocytes. Regul Peptides 2007;142(1–2):16–23.
    • (2007) Regul Peptides , vol.142 , Issue.1-2 , pp. 16-23
    • Chen, Z.-X.1    Chang, M.2    Peng, Y.-L.3    Zhao, L.4    Zhan, Y.-R.5    Wang, L.-J.6    Wang, R.7
  • 330
    • 27844487984 scopus 로고    scopus 로고
    • ERK1/2-activated de novo Mapkapk2 synthesis is essential for osteogenic growth peptide mitogenic signaling in osteoblastic cells
    • Miguel SMS, Namdar-Attar M, Noh T, Frenkel B, Bab I. ERK1/2-activated de novo Mapkapk2 synthesis is essential for osteogenic growth peptide mitogenic signaling in osteoblastic cells. J Biol Chem 2005;280(45):37495–37502.
    • (2005) J Biol Chem , vol.280 , Issue.45 , pp. 37495-37502
    • Miguel, S.M.S.1    Namdar-Attar, M.2    Noh, T.3    Frenkel, B.4    Bab, I.5
  • 331
    • 46449123757 scopus 로고    scopus 로고
    • The small peptide OGP(10–14) acts through Src kinases and RhoA pathways in Mo-7e cells: Morphologic and immunologic evaluation
    • Mattii L, Battolla B, Moscato S, Fazzi R, Galimberti S, Bernardini N, Dolfi A, Petrini M. The small peptide OGP(10–14) acts through Src kinases and RhoA pathways in Mo-7e cells: Morphologic and immunologic evaluation. Med Sci Monit 2008;14(6):103–108.
    • (2008) Med Sci Monit , vol.14 , Issue.6 , pp. 103-108
    • Mattii, L.1    Battolla, B.2    Moscato, S.3    Fazzi, R.4    Galimberti, S.5    Bernardini, N.6    Dolfi, A.7    Petrini, M.8
  • 333
    • 0037061669 scopus 로고    scopus 로고
    • Bioactive pseudopeptidic analogues and cyclostereoisomers of osteogenic growth peptide C-terminal pentapeptide, OGP(10–14)
    • Chen YC, Muhlrad A, Shteyer A, Vidson M, Bab I, Chorev M. Bioactive pseudopeptidic analogues and cyclostereoisomers of osteogenic growth peptide C-terminal pentapeptide, OGP(10–14). J Med Chem 2002;45(8):1624–1632.
    • (2002) J Med Chem , vol.45 , Issue.8 , pp. 1624-1632
    • Chen, Y.C.1    Muhlrad, A.2    Shteyer, A.3    Vidson, M.4    Bab, I.5    Chorev, M.6
  • 334
    • 73249137506 scopus 로고    scopus 로고
    • The use of immobilized osteogenic growth peptide on gradient substrates synthesized via click chemistry to enhance MC3T3-E1 osteoblast proliferation
    • Moore NM, Lin NJ, Gallant ND, Becker ML. The use of immobilized osteogenic growth peptide on gradient substrates synthesized via click chemistry to enhance MC3T3-E1 osteoblast proliferation. Biomaterials 2010;31(7):1604–1611.
    • (2010) Biomaterials , vol.31 , Issue.7 , pp. 1604-1611
    • Moore, N.M.1    Lin, N.J.2    Gallant, N.D.3    Becker, M.L.4
  • 336
    • 84755161376 scopus 로고    scopus 로고
    • Isolation and characterization of a novel peptide, osteoblast activating peptide (OBAP), associated with osteoblast differentiation and bone formation
    • Fukushima N, Hiraoka K, Shirachi I, Kojima M, Nagata K. Isolation and characterization of a novel peptide, osteoblast activating peptide (OBAP), associated with osteoblast differentiation and bone formation. Biochem Biophys Res Commun 2010;400(1):157–163.
    • (2010) Biochem Biophys Res Commun , vol.400 , Issue.1 , pp. 157-163
    • Fukushima, N.1    Hiraoka, K.2    Shirachi, I.3    Kojima, M.4    Nagata, K.5
  • 337
    • 34347391527 scopus 로고    scopus 로고
    • Egg yolk soluble protein stimulates the proliferation and differentiation of osteoblastic MC3T3-E1 cells
    • Ji M, Leem KH, Kim M, Kim HK. Egg yolk soluble protein stimulates the proliferation and differentiation of osteoblastic MC3T3-E1 cells. Biosci Biotechnol Biochem 2007;71(5):1327–1329.
    • (2007) Biosci Biotechnol Biochem , vol.71 , Issue.5 , pp. 1327-1329
    • Ji, M.1    Leem, K.H.2    Kim, M.3    Kim, H.K.4
  • 338
    • 79952188659 scopus 로고    scopus 로고
    • Protective effect of egg yolk peptide on bone metabolism
    • Kim HK, Lee S, Leem KH. Protective effect of egg yolk peptide on bone metabolism. Menopause 2011;18(3):307–313.
    • (2011) Menopause , vol.18 , Issue.3 , pp. 307-313
    • Kim, H.K.1    Lee, S.2    Leem, K.H.3
  • 339
    • 84908133335 scopus 로고    scopus 로고
    • Effects of egg yolk-derived peptide on osteogenic gene expression and MAPK activation
    • Kim HK, Kim MG, Leem KH. Effects of egg yolk-derived peptide on osteogenic gene expression and MAPK activation. Molecules 2014;19(9):12909–12924.
    • (2014) Molecules , vol.19 , Issue.9 , pp. 12909-12924
    • Kim, H.K.1    Kim, M.G.2    Leem, K.H.3
  • 340
    • 33644986723 scopus 로고    scopus 로고
    • MAP kinase signaling cascades and gene expression in osteoblasts
    • Hipskind RA, Bilbe G. MAP kinase signaling cascades and gene expression in osteoblasts. Front Biosci 1998;1(3):d804–d816.
    • (1998) Front Biosci , vol.1 , Issue.3 , pp. d804-d816
    • Hipskind, R.A.1    Bilbe, G.2
  • 342
    • 0024104359 scopus 로고
    • Synthetic peptides bind to high-affinity thrombin receptors and modulate thrombin mitogenesis
    • Glenn KC, Frost GH, Bergmann JS, Carney DH. Synthetic peptides bind to high-affinity thrombin receptors and modulate thrombin mitogenesis. Pept Res 1988;1(2):65–73.
    • (1988) Pept Res , vol.1 , Issue.2 , pp. 65-73
    • Glenn, K.C.1    Frost, G.H.2    Bergmann, J.S.3    Carney, D.H.4
  • 344
    • 4344630571 scopus 로고    scopus 로고
    • Acceleration of fresh fracture healing with an injectable thrombin peptide in a rat model
    • Ryaby J, Carney D, Campbell M, Crowther R, Yang J, Bain S, Simmons D. Acceleration of fresh fracture healing with an injectable thrombin peptide in a rat model. Trans ORS 2000;25:877.
    • (2000) Trans ORS , vol.25 , pp. 877
    • Ryaby, J.1    Carney, D.2    Campbell, M.3    Crowther, R.4    Yang, J.5    Bain, S.6    Simmons, D.7
  • 345
    • 18244410123 scopus 로고    scopus 로고
    • Thrombin peptide (TP508) promotes fracture repair by up-regulating inflammatory mediators, early growth factors, and increasing angiogenesis
    • Wang H, Li X, Tomin E, Doty SB, Lane JM, Carney DH, Ryaby JT. Thrombin peptide (TP508) promotes fracture repair by up-regulating inflammatory mediators, early growth factors, and increasing angiogenesis. J Orthop Res 2005;23(3):671–679.
    • (2005) J Orthop Res , vol.23 , Issue.3 , pp. 671-679
    • Wang, H.1    Li, X.2    Tomin, E.3    Doty, S.B.4    Lane, J.M.5    Carney, D.H.6    Ryaby, J.T.7
  • 346
    • 18244410123 scopus 로고    scopus 로고
    • Thrombin peptide (TP508) promotes fracture repair by up-regulating inflammatory mediators, early growth factors, and increasing angiogenesis
    • Wang H, Li X, Tomin E, Doty SB, Lane JM, Carney DH, Ryaby JT. Thrombin peptide (TP508) promotes fracture repair by up-regulating inflammatory mediators, early growth factors, and increasing angiogenesis. J Orthop Res 2005;23(3):671–679.
    • (2005) J Orthop Res , vol.23 , Issue.3 , pp. 671-679
    • Wang, H.1    Li, X.2    Tomin, E.3    Doty, S.B.4    Lane, J.M.5    Carney, D.H.6    Ryaby, J.T.7
  • 348
    • 18244364350 scopus 로고    scopus 로고
    • rhBMP-2, rhVEGF(165), rhPTN and thrombin-related peptide, TP508 induce chemotaxis of human osteoblasts and microvascular endothelial cells
    • Li G, Cui Y, McIlmurray L, Allen WE, Wang H. rhBMP-2, rhVEGF(165), rhPTN and thrombin-related peptide, TP508 induce chemotaxis of human osteoblasts and microvascular endothelial cells. J Orthop Res 2005;23(3):680–685.
    • (2005) J Orthop Res , vol.23 , Issue.3 , pp. 680-685
    • Li, G.1    Cui, Y.2    McIlmurray, L.3    Allen, W.E.4    Wang, H.5
  • 349
    • 11044232864 scopus 로고    scopus 로고
    • Bone formation is enhanced by thrombin-related peptide TP508 during distraction osteogenesis
    • Li G, Ryaby JT, Carney DH, Wang H. Bone formation is enhanced by thrombin-related peptide TP508 during distraction osteogenesis. J Orthop Res 2005;23(1):196–202.
    • (2005) J Orthop Res , vol.23 , Issue.1 , pp. 196-202
    • Li, G.1    Ryaby, J.T.2    Carney, D.H.3    Wang, H.4
  • 350
    • 78649659248 scopus 로고    scopus 로고
    • Acceleration of consolidation period by thrombin peptide 508 in tibial distraction osteogenesis in rats
    • Cakarer S, Olgac V, Aksakalli N, Tang A, Keskin C. Acceleration of consolidation period by thrombin peptide 508 in tibial distraction osteogenesis in rats. Br J Oral Maxillofac Surg 2010;48(8):633–636.
    • (2010) Br J Oral Maxillofac Surg , vol.48 , Issue.8 , pp. 633-636
    • Cakarer, S.1    Olgac, V.2    Aksakalli, N.3    Tang, A.4    Keskin, C.5
  • 351
    • 61849169023 scopus 로고    scopus 로고
    • Thrombin related peptide TP508 promoted fracture repair in a mouse high energy fracture model
    • Hanratty BM, Ryaby JT, Pan XH, Li G. Thrombin related peptide TP508 promoted fracture repair in a mouse high energy fracture model. J Orthop Surg Res 2009;4(1):4–1.
    • (2009) J Orthop Surg Res , vol.4 , Issue.1 , pp. 1-4
    • Hanratty, B.M.1    Ryaby, J.T.2    Pan, X.H.3    Li, G.4
  • 353
    • 14644444227 scopus 로고    scopus 로고
    • Effect of varied release kinetics of the osteogenic thrombin peptide TP508 from biodegradable, polymeric scaffolds on bone formation in vivo
    • Hedberg EL, Kroese-Deutman HC, Shih CK, Crowther RS, Carney DH, Mikos AG, Jansen JA. Effect of varied release kinetics of the osteogenic thrombin peptide TP508 from biodegradable, polymeric scaffolds on bone formation in vivo. J Biomed Mater Res 2005;72A(4):343–353.
    • (2005) J Biomed Mater Res , vol.72A , Issue.4 , pp. 343-353
    • Hedberg, E.L.1    Kroese-Deutman, H.C.2    Shih, C.K.3    Crowther, R.S.4    Carney, D.H.5    Mikos, A.G.6    Jansen, J.A.7
  • 354
    • 41649110124 scopus 로고    scopus 로고
    • Local injection of thrombin-related peptide (TP508) in PPF/PLGA microparticles-enhanced bone formation during distraction osteogenesis
    • Wang Y, Wan C, Szoke G, Ryaby JT, Li G. Local injection of thrombin-related peptide (TP508) in PPF/PLGA microparticles-enhanced bone formation during distraction osteogenesis. J Orthop Res 2008;26(4):539–546.
    • (2008) J Orthop Res , vol.26 , Issue.4 , pp. 539-546
    • Wang, Y.1    Wan, C.2    Szoke, G.3    Ryaby, J.T.4    Li, G.5
  • 355
    • 33750695006 scopus 로고    scopus 로고
    • Thrombin peptide TP508 stimulates cellular events leading to angiogenesis, revascularization, and repair of dermal and musculoskeletal tissues
    • Ryaby JT, Sheller MR, Levine BP, Bramlet DG, Ladd AL, Carney DH. Thrombin peptide TP508 stimulates cellular events leading to angiogenesis, revascularization, and repair of dermal and musculoskeletal tissues. J Bone Joint Surg Am 2006;3:132–139.
    • (2006) J Bone Joint Surg Am , vol.3 , pp. 132-139
    • Ryaby, J.T.1    Sheller, M.R.2    Levine, B.P.3    Bramlet, D.G.4    Ladd, A.L.5    Carney, D.H.6
  • 356
    • 55249122720 scopus 로고    scopus 로고
    • Could rusalatide acetate be the future drug of choice for diabetic foot ulcers and fracture repair?
    • Carney DH, Olszewska-Pazdrak B. Could rusalatide acetate be the future drug of choice for diabetic foot ulcers and fracture repair? Expert Opin Pharmacother 2008;9(15):2717–2726.
    • (2008) Expert Opin Pharmacother , vol.9 , Issue.15 , pp. 2717-2726
    • Carney, D.H.1    Olszewska-Pazdrak, B.2
  • 357
    • 84974706676 scopus 로고    scopus 로고
    • Capstone Therapeutics Announces Operational Update. http://capstonethx.com/2012.
  • 358
    • 84974693598 scopus 로고    scopus 로고
    • Chrysalis Biotherapeutics. http://www.chrysbio.com/therapeutic-targets/regenerative-medicine.
  • 359
    • 34247645937 scopus 로고    scopus 로고
    • Functional expression of N-formyl peptide receptors in human bone marrow-derived mesenchymal stem cells
    • Viswanathan A, Painter RG, Lanson NA, Wang G. Functional expression of N-formyl peptide receptors in human bone marrow-derived mesenchymal stem cells. Stem Cells 2007;25(5):1263–1269.
    • (2007) Stem Cells , vol.25 , Issue.5 , pp. 1263-1269
    • Viswanathan, A.1    Painter, R.G.2    Lanson, N.A.3    Wang, G.4
  • 360
    • 0021333230 scopus 로고
    • Purification and identification of formyl-methionyl-leucyl-phenylalanine as the major peptide neutrophil chemotactic factor produced by Escherichia coli
    • Marasco WA, Phan SH, Krutzsch H, Showell HJ, Feltner DE, Nairn R, Becker EL, Ward PA. Purification and identification of formyl-methionyl-leucyl-phenylalanine as the major peptide neutrophil chemotactic factor produced by Escherichia coli. J Biol Chem 1984;259(9):5430–5439.
    • (1984) J Biol Chem , vol.259 , Issue.9 , pp. 5430-5439
    • Marasco, W.A.1    Phan, S.H.2    Krutzsch, H.3    Showell, H.J.4    Feltner, D.E.5    Nairn, R.6    Becker, E.L.7    Ward, P.A.8
  • 361
    • 34247141961 scopus 로고    scopus 로고
    • Expression and functional role of formyl peptide receptor in human bone marrow-derived mesenchymal stem cells
    • Kim M-K, Min DS, Park YJ, Kim JH, Ryu SH, Bae Y-S. Expression and functional role of formyl peptide receptor in human bone marrow-derived mesenchymal stem cells. FEBS Lett 2007;581(9):1917–1922.
    • (2007) FEBS Lett , vol.581 , Issue.9 , pp. 1917-1922
    • Kim, M.-K.1    Min, D.S.2    Park, Y.J.3    Kim, J.H.4    Ryu, S.H.5    Bae, Y.-S.6
  • 362
    • 79955765267 scopus 로고    scopus 로고
    • N-formyl-methionyl-leucyl-phenylalanine (fMLP) promotes osteoblast differentiation via the N-formyl peptide receptor 1-mediated signaling pathway in human mesenchymal stem cells from bone marrow
    • Shin MK, Jang YH, Yoo HJ, Kang DW, Park MH, Kim MK, Song JH, Kim SD, Min G, You HK, Choi K-Y, Bae Y-S, Min DS. N-formyl-methionyl-leucyl-phenylalanine (fMLP) promotes osteoblast differentiation via the N-formyl peptide receptor 1-mediated signaling pathway in human mesenchymal stem cells from bone marrow. J Biol Chem 2011;286(19):17133–17143.
    • (2011) J Biol Chem , vol.286 , Issue.19 , pp. 17133-17143
    • Shin, M.K.1    Jang, Y.H.2    Yoo, H.J.3    Kang, D.W.4    Park, M.H.5    Kim, M.K.6    Song, J.H.7    Kim, S.D.8    Min, G.9    You, H.K.10    Choi, K.-Y.11    Bae, Y.-S.12    Min, D.S.13
  • 363
    • 0025740387 scopus 로고
    • Selective secretion of annexin 1, a protein without a signal sequence, by the human prostate gland
    • Christmas P, Callaway J, Fallon J, Jones J, Haigler HT. Selective secretion of annexin 1, a protein without a signal sequence, by the human prostate gland. J Biol Chem 1991;266(4):2499–2507.
    • (1991) J Biol Chem , vol.266 , Issue.4 , pp. 2499-2507
    • Christmas, P.1    Callaway, J.2    Fallon, J.3    Jones, J.4    Haigler, H.T.5
  • 364
    • 0034811304 scopus 로고    scopus 로고
    • Annexin 1 peptides protect against experimental myocardial ischemia-reperfusion: Analysis of their mechanism of action
    • La M, D'Amico M, Bandiera S, Di Filippo C, Oliani SM, Gavins FN, Flower RJ, Perretti M. Annexin 1 peptides protect against experimental myocardial ischemia-reperfusion: Analysis of their mechanism of action. FASEB J 2001;15(12):2247–2256.
    • (2001) FASEB J , vol.15 , Issue.12 , pp. 2247-2256
    • La, M.1    D'Amico, M.2    Bandiera, S.3    Di Filippo, C.4    Oliani, S.M.5    Gavins, F.N.6    Flower, R.J.7    Perretti, M.8
  • 365
    • 84867334961 scopus 로고    scopus 로고
    • Iron homeostasis in osteoporosis and its clinical implications
    • Li GF, Pan YZ, Sirois P, Li K, Xu YJ. Iron homeostasis in osteoporosis and its clinical implications. Osteoporos Int 2012;23(10):2403–2408.
    • (2012) Osteoporos Int , vol.23 , Issue.10 , pp. 2403-2408
    • Li, G.F.1    Pan, Y.Z.2    Sirois, P.3    Li, K.4    Xu, Y.J.5
  • 366
    • 84899649150 scopus 로고    scopus 로고
    • Hepcidin deficiency undermines bone load-bearing capacity through inducing iron overload
    • Sun L, Guo W, Yin C, Zhang S, Qu G, Hou Y, Rong H, Ji H, Liu S. Hepcidin deficiency undermines bone load-bearing capacity through inducing iron overload. Gene 2014;543(1):161–165.
    • (2014) Gene , vol.543 , Issue.1 , pp. 161-165
    • Sun, L.1    Guo, W.2    Yin, C.3    Zhang, S.4    Qu, G.5    Hou, Y.6    Rong, H.7    Ji, H.8    Liu, S.9
  • 367
    • 58149512144 scopus 로고    scopus 로고
    • Role of iron in osteoporosis
    • Weinberg ED. Role of iron in osteoporosis. Pediatr Endocrinol Rev 2008;1:81–85.
    • (2008) Pediatr Endocrinol Rev , vol.1 , pp. 81-85
    • Weinberg, E.D.1
  • 368
    • 1642386686 scopus 로고    scopus 로고
    • Organization and expression analysis of the zebrafish hepcidin gene, an antimicrobial peptide gene conserved among vertebrates
    • Shike H, Shimizu C, Lauth X, Burns JC. Organization and expression analysis of the zebrafish hepcidin gene, an antimicrobial peptide gene conserved among vertebrates. Dev Comp Immunol 2004;28(7–8):747–754.
    • (2004) Dev Comp Immunol , vol.28 , Issue.7-8 , pp. 747-754
    • Shike, H.1    Shimizu, C.2    Lauth, X.3    Burns, J.C.4
  • 369
    • 10844258104 scopus 로고    scopus 로고
    • Hepcidin regulates cellular iron efflux by binding to ferroportin and inducing its internalization
    • Nemeth E, Tuttle MS, Powelson J, Vaughn MB, Donovan A, Ward DM, Ganz T, Kaplan J. Hepcidin regulates cellular iron efflux by binding to ferroportin and inducing its internalization. Science 2004;306(5704):2090–2093.
    • (2004) Science , vol.306 , Issue.5704 , pp. 2090-2093
    • Nemeth, E.1    Tuttle, M.S.2    Powelson, J.3    Vaughn, M.B.4    Donovan, A.5    Ward, D.M.6    Ganz, T.7    Kaplan, J.8
  • 370
    • 79551649662 scopus 로고    scopus 로고
    • A preliminary report of expression of hepcidin gene in SD rats osteoporosis model [J]
    • Ma Y, Xu Y-J. A preliminary report of expression of hepcidin gene in SD rats osteoporosis model [J]. Suzhou Univ J Med Sci 2006;26(3):367–369.
    • (2006) Suzhou Univ J Med Sci , vol.26 , Issue.3 , pp. 367-369
    • Ma, Y.1    Xu, Y.-J.2
  • 371
    • 84974731878 scopus 로고    scopus 로고
    • Treatment of osteoporosis in peri- and post- menopausal women with hepcidin
    • Huang X. Treatment of osteoporosis in peri- and post- menopausal women with hepcidin. US Patent Application US20100204122 A1. 2010.
    • (2010) US Patent Application US20100204122 A1
    • Huang, X.1
  • 373
    • 79551632249 scopus 로고    scopus 로고
    • Increased intracellular iron and mineralization of cultured hFOB 1.19 cells following hepcidin activation through ferroportin-1
    • Zhang P, Xu YJ, Zhao DY, Ma Y, Xiao L, Feng YS, Du BC, Qian ZM, Li K. Increased intracellular iron and mineralization of cultured hFOB 1.19 cells following hepcidin activation through ferroportin-1. Saudi Med J 2010;31(12):1303–1308.
    • (2010) Saudi Med J , vol.31 , Issue.12 , pp. 1303-1308
    • Zhang, P.1    Xu, Y.J.2    Zhao, D.Y.3    Ma, Y.4    Xiao, L.5    Feng, Y.S.6    Du, B.C.7    Qian, Z.M.8    Li, K.9
  • 374
    • 84916232307 scopus 로고    scopus 로고
    • Hepcidin promotes osteogenic differentiation through the bone morphogenetic protein 2/small mothers against decapentaplegic and mitogen-activated protein kinase/P38 signaling pathways in mesenchymal stem cells
    • Lu H, Lian L, Shi D, Zhao H, Dai Y. Hepcidin promotes osteogenic differentiation through the bone morphogenetic protein 2/small mothers against decapentaplegic and mitogen-activated protein kinase/P38 signaling pathways in mesenchymal stem cells. Mol Med Rep 2015;11(1):143–150.
    • (2015) Mol Med Rep , vol.11 , Issue.1 , pp. 143-150
    • Lu, H.1    Lian, L.2    Shi, D.3    Zhao, H.4    Dai, Y.5
  • 375
    • 84939886817 scopus 로고    scopus 로고
    • Effects of mouse hepcidin 1 treatment on osteoclast differentiation and intracellular iron concentration
    • Zhao GY, Di DH, Wang B, Huang X, Xu YJ. Effects of mouse hepcidin 1 treatment on osteoclast differentiation and intracellular iron concentration. Inflammation 2015;38(2):718–727.
    • (2015) Inflammation , vol.38 , Issue.2 , pp. 718-727
    • Zhao, G.Y.1    Di, D.H.2    Wang, B.3    Huang, X.4    Xu, Y.J.5
  • 377
    • 80054841445 scopus 로고    scopus 로고
    • Casein kinase 2 regulates in vivo bone formation through its interaction with bone morphogenetic protein receptor type Ia
    • Bragdon B, Thinakaran S, Moseychuk O, Gurski L, Bonor J, Price C, Wang L, Beamer WG, Nohe A. Casein kinase 2 regulates in vivo bone formation through its interaction with bone morphogenetic protein receptor type Ia. Bone 2011;49(5):944–954.
    • (2011) Bone , vol.49 , Issue.5 , pp. 944-954
    • Bragdon, B.1    Thinakaran, S.2    Moseychuk, O.3    Gurski, L.4    Bonor, J.5    Price, C.6    Wang, L.7    Beamer, W.G.8    Nohe, A.9
  • 379
    • 0041845297 scopus 로고    scopus 로고
    • E3 ubiquitin ligase Smurf1 mediates core-binding factor α1/Runx2 degradation and plays a specific role in osteoblast differentiation
    • Zhao M, Qiao M, Oyajobi BO, Mundy GR, Chen D. E3 ubiquitin ligase Smurf1 mediates core-binding factor α1/Runx2 degradation and plays a specific role in osteoblast differentiation. J Biol Chem 2003;278(30):27939–27944.
    • (2003) J Biol Chem , vol.278 , Issue.30 , pp. 27939-27944
    • Zhao, M.1    Qiao, M.2    Oyajobi, B.O.3    Mundy, G.R.4    Chen, D.5
  • 380
    • 84862753576 scopus 로고    scopus 로고
    • Regulation of osteoblastic differentiation by the proteasome inhibitor bortezomib
    • Uyama M, Sato MM, Kawanami M, Tamura M. Regulation of osteoblastic differentiation by the proteasome inhibitor bortezomib. Genes Cells 2012;17(7):548–558.
    • (2012) Genes Cells , vol.17 , Issue.7 , pp. 548-558
    • Uyama, M.1    Sato, M.M.2    Kawanami, M.3    Tamura, M.4
  • 381
    • 70450227260 scopus 로고    scopus 로고
    • Proteasome inhibitors in the treatment of multiple myeloma
    • Shah J, Orlowski R. Proteasome inhibitors in the treatment of multiple myeloma. Leukemia 2009;23(11):1964–1979.
    • (2009) Leukemia , vol.23 , Issue.11 , pp. 1964-1979
    • Shah, J.1    Orlowski, R.2
  • 382
    • 33947356281 scopus 로고    scopus 로고
    • Bortezomib-mediated 26S proteasome inhibition causes cell-cycle arrest and induces apoptosis in CD-30+ anaplastic large cell lymphoma
    • Bonvini P, Zorzi E, Basso G, Rosolen A. Bortezomib-mediated 26S proteasome inhibition causes cell-cycle arrest and induces apoptosis in CD-30+ anaplastic large cell lymphoma. Leukemia 2007;21:838–842.
    • (2007) Leukemia , vol.21 , pp. 838-842
    • Bonvini, P.1    Zorzi, E.2    Basso, G.3    Rosolen, A.4
  • 385
    • 58149478516 scopus 로고    scopus 로고
    • The proteasome inhibitor, bortezomib suppresses primary myeloma and stimulates bone formation in myelomatous and nonmyelomatous bones in vivo
    • Pennisi A, Li X, Ling W, Khan S, Zangari M, Yaccoby S. The proteasome inhibitor, bortezomib suppresses primary myeloma and stimulates bone formation in myelomatous and nonmyelomatous bones in vivo. Am J Hematol 2009;84(1):6–14.
    • (2009) Am J Hematol , vol.84 , Issue.1 , pp. 6-14
    • Pennisi, A.1    Li, X.2    Ling, W.3    Khan, S.4    Zangari, M.5    Yaccoby, S.6
  • 387
    • 66149127277 scopus 로고    scopus 로고
    • Bortezomib induces osteoblast differentiation via Wnt-independent activation of beta-catenin/TCF signaling
    • Qiang YW, Hu B, Chen Y, Zhong Y, Shi B, Barlogie B, Shaughnessy JD, Jr. Bortezomib induces osteoblast differentiation via Wnt-independent activation of beta-catenin/TCF signaling. Blood 2009;113(18):4319–4330.
    • (2009) Blood , vol.113 , Issue.18 , pp. 4319-4330
    • Qiang, Y.W.1    Hu, B.2    Chen, Y.3    Zhong, Y.4    Shi, B.5    Barlogie, B.6    Shaughnessy, J.D.7
  • 388
    • 84875260832 scopus 로고    scopus 로고
    • The proteasome inhibitor bortezomib stimulates osteoblastic differentiation of human osteoblast precursors via upregulation of vitamin D receptor signalling
    • Kaiser MF, Heider U, Mieth M, Zang C, von Metzler I, Sezer O. The proteasome inhibitor bortezomib stimulates osteoblastic differentiation of human osteoblast precursors via upregulation of vitamin D receptor signalling. Eur J Haematol 2013;90(4):263–272.
    • (2013) Eur J Haematol , vol.90 , Issue.4 , pp. 263-272
    • Kaiser, M.F.1    Heider, U.2    Mieth, M.3    Zang, C.4    von Metzler, I.5    Sezer, O.6
  • 390
    • 48949107708 scopus 로고    scopus 로고
    • Pulse treatment with the proteasome inhibitor bortezomib inhibits osteoclast resorptive activity in clinically relevant conditions
    • Boissy P, Andersen TL, Lund T, Kupisiewicz K, Plesner T, Delaisse JM. Pulse treatment with the proteasome inhibitor bortezomib inhibits osteoclast resorptive activity in clinically relevant conditions. Leuk Res 2008;32(11):1661–1668.
    • (2008) Leuk Res , vol.32 , Issue.11 , pp. 1661-1668
    • Boissy, P.1    Andersen, T.L.2    Lund, T.3    Kupisiewicz, K.4    Plesner, T.5    Delaisse, J.M.6
  • 391
    • 84903162356 scopus 로고    scopus 로고
    • HDAC4 integrates PTH and sympathetic signaling in osteoblasts
    • Obri A, Makinistoglu MP, Zhang H, Karsenty G. HDAC4 integrates PTH and sympathetic signaling in osteoblasts. J Cell Biol 2014;205(6):771–780.
    • (2014) J Cell Biol , vol.205 , Issue.6 , pp. 771-780
    • Obri, A.1    Makinistoglu, M.P.2    Zhang, H.3    Karsenty, G.4
  • 393
    • 33646433058 scopus 로고    scopus 로고
    • Regulation of bone mass by Wnt signaling
    • Krishnan V, Bryant HU, Macdougald OA. Regulation of bone mass by Wnt signaling. J Clin Invest 2006;116(5):1202–1209.
    • (2006) J Clin Invest , vol.116 , Issue.5 , pp. 1202-1209
    • Krishnan, V.1    Bryant, H.U.2    Macdougald, O.A.3
  • 399
    • 84904563953 scopus 로고    scopus 로고
    • Carfilzomib promotes the osteogenic differentiation potential of mesenchymal stem cells derived from myeloma patients by inhibiting notch1 activity in vitro
    • Li Y, Li J, Zhuang W, Wang Q, Ge X, Zhang X, Chen P, Fu J, Li B. Carfilzomib promotes the osteogenic differentiation potential of mesenchymal stem cells derived from myeloma patients by inhibiting notch1 activity in vitro. Leuk Res 2014;38(8):970–976.
    • (2014) Leuk Res , vol.38 , Issue.8 , pp. 970-976
    • Li, Y.1    Li, J.2    Zhuang, W.3    Wang, Q.4    Ge, X.5    Zhang, X.6    Chen, P.7    Fu, J.8    Li, B.9
  • 401
    • 84936750685 scopus 로고    scopus 로고
    • The proteasome inhibitor carfilzomib suppresses parathyroid hormone-induced osteoclastogenesis through a RANKL-mediated signaling pathway
    • Yang Y, Blair HC, Shapiro IM, Wang B. The proteasome inhibitor carfilzomib suppresses parathyroid hormone-induced osteoclastogenesis through a RANKL-mediated signaling pathway. J Biol Chem 2015;290(27):16918–16928.
    • (2015) J Biol Chem , vol.290 , Issue.27 , pp. 16918-16928
    • Yang, Y.1    Blair, H.C.2    Shapiro, I.M.3    Wang, B.4
  • 402
    • 33644845743 scopus 로고    scopus 로고
    • Crystal structure of the boronic acid-based proteasome inhibitor bortezomib in complex with the yeast 20S proteasome
    • Groll M, Berkers CR, Ploegh HL, Ovaa H. Crystal structure of the boronic acid-based proteasome inhibitor bortezomib in complex with the yeast 20S proteasome. Structure 2006;14(3):451–456.
    • (2006) Structure , vol.14 , Issue.3 , pp. 451-456
    • Groll, M.1    Berkers, C.R.2    Ploegh, H.L.3    Ovaa, H.4


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