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Volumn 167, Issue 5, 2012, Pages 601-608

Ghrelin: The differences between acyl- and des-acyl ghrelin

Author keywords

[No Author keywords available]

Indexed keywords

ACYL GRHELIN; AGENTS AFFECTING METABOLISM; BIM 28163; DES ACYL GRHELIN; GHRELIN; GHRELIN RECEPTOR; GLUCOSE; INSULIN; PLACEBO; RECEPTOR BLOCKING AGENT; UNCLASSIFIED DRUG; GHRELIN, DES N OCTANOYL; GHRELIN, DES-N-OCTANOYL;

EID: 84867569409     PISSN: 08044643     EISSN: 1479683X     Source Type: Journal    
DOI: 10.1530/EJE-12-0456     Document Type: Review
Times cited : (199)

References (58)
  • 1
    • 0033540056 scopus 로고    scopus 로고
    • Ghrelin is a growth-hormone-releasing acylated peptide from stomach
    • doi:10.1038/45230
    • Kojima M, Hosoda H, Date Y, Nakazato M, Matsuo H & Kangawa K. Ghrelin is a growth-hormone-releasing acylated peptide from stomach. Nature 1999 402 656-660. (doi:10.1038/45230)
    • (1999) Nature , vol.402 , pp. 656-660
    • Kojima, M.1    Hosoda, H.2    Date, Y.3    Nakazato, M.4    Matsuo, H.5    Kangawa, K.6
  • 2
    • 77954229592 scopus 로고    scopus 로고
    • Changes in acyl ghrelin, des-acyl ghrelin, and ratio of acyl ghrelin to total ghrelin with short-term refeeding in female inpatients with restricting-type anorexia nervosa
    • doi:10.1055/s-0030-1252017
    • Koyama KI, Yasuhara D, Nakahara T, Harada T, Uehara M, Ushikai M, Asakawa A & Inui A. Changes in acyl ghrelin, des-acyl ghrelin, and ratio of acyl ghrelin to total ghrelin with short-term refeeding in female inpatients with restricting-type anorexia nervosa. Hormone and Metabolic Research 2010 42 595-598. (doi:10.1055/s-0030-1252017)
    • (2010) Hormone and Metabolic Research , vol.42 , pp. 595-598
    • Koyama, K.I.1    Yasuhara, D.2    Nakahara, T.3    Harada, T.4    Uehara, M.5    Ushikai, M.6    Asakawa, A.7    Inui, A.8
  • 4
    • 38849090670 scopus 로고    scopus 로고
    • Identification of the acyltransferase that octanoylates ghrelin, an appetite-stimulating peptide hormone
    • doi:10.1016/j.cell.2008.01.017
    • Yang J, Brown MS, Liang G, Grishin NV & Goldstein JL. Identification of the acyltransferase that octanoylates ghrelin, an appetite-stimulating peptide hormone. Cell 2008 132 387-396. (doi:10.1016/j.cell.2008.01.017)
    • (2008) Cell , vol.132 , pp. 387-396
    • Yang, J.1    Brown, M.S.2    Liang, G.3    Grishin, N.V.4    Goldstein, J.L.5
  • 6
  • 7
    • 34547157499 scopus 로고    scopus 로고
    • Unacylated ghrelin is not a functional antagonist but a full agonist of the type 1a growth hormone secretagogue receptor (GHS-R)
    • doi:10.1016/j.mce.2007.05.010
    • Gauna C, van de Zande B, van Kerkwijk A, Themmen AP, van der Lely AJ & Delhanty PJ. Unacylated ghrelin is not a functional antagonist but a full agonist of the type 1a growth hormone secretagogue receptor (GHS-R). Molecular and Cellular Endocrinology 2007 274 30-34. (doi:10.1016/j.mce.2007.05.010)
    • (2007) Molecular and Cellular Endocrinology , vol.274 , pp. 30-34
    • Gauna, C.1    Van De Zande, B.2    Van Kerkwijk, A.3    Themmen, A.P.4    Van Der Lely, A.J.5    Delhanty, P.J.6
  • 9
    • 33751506108 scopus 로고    scopus 로고
    • Hyperphagia alters expression of hypothalamic 5-HT2C and 5-HT1B receptor genes and plasma des-acyl ghrelin levels in Ay mice
    • doi:10.1210/en.2006-0418
    • Nonogaki K, Nozue K & Oka Y. Hyperphagia alters expression of hypothalamic 5-HT2C and 5-HT1B receptor genes and plasma des-acyl ghrelin levels in Ay mice. Endocrinology 2006 147 5893-5900. (doi:10.1210/en.2006-0418)
    • (2006) Endocrinology , vol.147 , pp. 5893-5900
    • Nonogaki, K.1    Nozue, K.2    Oka, Y.3
  • 10
    • 72949115929 scopus 로고    scopus 로고
    • Acylated and nonacylated ghrelin levels and their associations with insulin resistance in obese and normal weight children with metabolic syndrome
    • doi:10.1530/EJE-09-0375
    • Pacifico L, Poggiogalle E, Costantino F, Anania C, Ferraro F, Chiarelli F & Chiesa C. Acylated and nonacylated ghrelin levels and their associations with insulin resistance in obese and normal weight children with metabolic syndrome. European Journal of Endocrinology 2009 161 861-870. (doi:10.1530/EJE-09-0375)
    • (2009) European Journal of Endocrinology , vol.161 , pp. 861-870
    • Pacifico, L.1    Poggiogalle, E.2    Costantino, F.3    Anania, C.4    Ferraro, F.5    Chiarelli, F.6    Chiesa, C.7
  • 14
    • 79960839413 scopus 로고    scopus 로고
    • In adults with Prader-Willi syndrome, elevated ghrelin levels are more consistent with hyperphagia than high PYY and GLP-1 levels
    • doi:10.1016/j.npep.2011.06.001
    • Purtell L, Sze L, Loughnan G, Smith E, Herzog H, Sainsbury A, Steinbeck K, Campbell LV & Viardot A. In adults with Prader-Willi syndrome, elevated ghrelin levels are more consistent with hyperphagia than high PYY and GLP-1 levels. Neuropeptides 2011 45 301-307. (doi:10.1016/j.npep.2011.06.001)
    • (2011) Neuropeptides , vol.45 , pp. 301-307
    • Purtell, L.1    Sze, L.2    Loughnan, G.3    Smith, E.4    Herzog, H.5    Sainsbury, A.6    Steinbeck, K.7    Campbell, L.V.8    Viardot, A.9
  • 15
    • 84871029043 scopus 로고    scopus 로고
    • Appetite hormones and the transition to hyperphagia in children with Prader-Willi syndrome
    • In press. (doi:10.1038/ijo.2011.274)
    • Goldstone AP, Holland AJ, Butler JV & Whittington JE. Appetite hormones and the transition to hyperphagia in children with Prader-Willi syndrome. International Journal of Obesity 2012. In press. (doi:10.1038/ijo. 2011.274)
    • (2012) International Journal of Obesity
    • Goldstone, A.P.1    Holland, A.J.2    Butler, J.V.3    Whittington, J.E.4
  • 18
    • 29244486778 scopus 로고    scopus 로고
    • Acylated ghrelin stimulates food intake in the fed and fasted states but desacylated ghrelin has no effect [6]
    • Neary NM, Druce MR, Small CJ & Bloom SR. Acylated ghrelin stimulates food intake in the fed and fasted states but desacylated ghrelin has no effect. Gut 2006 55 135. (Pubitemid 41820653)
    • (2006) Gut , vol.55 , Issue.1 , pp. 135
    • Neary, N.M.1    Druce, M.R.2    Small, C.J.3    Bloom, S.R.4
  • 19
    • 77955842961 scopus 로고    scopus 로고
    • Proghrelin peptides: Desacyl ghrelin is a powerful inhibitor of acylated ghrelin, likely to impair physiological effects of acyl ghrelin but not of obestatin A study of pancreatic polypeptide secretion from mouse islets
    • doi:10.1016/j.regpep.2010.06.005
    • Kumar R, Salehi A, Rehfeld JF, Hoglund P, Lindstrom E & Hakanson R. Proghrelin peptides: desacyl ghrelin is a powerful inhibitor of acylated ghrelin, likely to impair physiological effects of acyl ghrelin but not of obestatin A study of pancreatic polypeptide secretion from mouse islets. Regulatory Peptides 2010 164 65-70. (doi:10.1016/j.regpep.2010.06.005)
    • (2010) Regulatory Peptides , vol.164 , pp. 65-70
    • Kumar, R.1    Salehi, A.2    Rehfeld, J.F.3    Hoglund, P.4    Lindstrom, E.5    Hakanson, R.6
  • 21
    • 33846435771 scopus 로고    scopus 로고
    • Acylated and unacylated ghrelin promote proliferation and inhibit apoptosis of pancreatic β-cells and human islets: Involvement of 3′,5′-cyclic adenosine monophosphate/protein kinase A, extracellular signal-regulated kinase 1/2, and phosphatidyl inositol 3-kinase/Akt signaling
    • doi:10.1210/en.2006-0266
    • Granata R, Settanni F, Biancone L, Trovato L, Nano R, Bertuzzi F, Destefanis S, Annunziata M, Martinetti M, Catapano F, Ghe C, Isgaard J, Papotti M, Ghigo E & Muccioli G. Acylated and unacylated ghrelin promote proliferation and inhibit apoptosis of pancreatic β-cells and human islets: involvement of 3′,5′-cyclic adenosine monophosphate/protein kinase A, extracellular signal-regulated kinase 1/2, and phosphatidyl inositol 3-kinase/Akt signaling. Endocrinology 2007 148 512-529. (doi:10.1210/en.2006- 0266)
    • (2007) Endocrinology , vol.148 , pp. 512-529
    • Granata, R.1    Settanni, F.2    Biancone, L.3    Trovato, L.4    Nano, R.5    Bertuzzi, F.6    Destefanis, S.7    Annunziata, M.8    Martinetti, M.9    Catapano, F.10    Ghe, C.11    Isgaard, J.12    Papotti, M.13    Ghigo, E.14    Muccioli, G.15
  • 23
    • 79251634954 scopus 로고    scopus 로고
    • Effect of desacyl ghrelin, obestatin and related peptides on triglyceride storage, metabolism and GHSR signaling in 3T3-L1 adipocytes
    • doi:10.1002/jcb.22983
    • Miegueu P, St Pierre D, Broglio F & Cianflone K. Effect of desacyl ghrelin, obestatin and related peptides on triglyceride storage, metabolism and GHSR signaling in 3T3-L1 adipocytes. Journal of Cellular Biochemistry 2011 112 704-714. (doi:10.1002/jcb.22983)
    • (2011) Journal of Cellular Biochemistry , vol.112 , pp. 704-714
    • Miegueu, P.1    St Pierre, D.2    Broglio, F.3    Cianflone, K.4
  • 24
    • 33646148717 scopus 로고    scopus 로고
    • The contractile effect of the ghrelin receptor antagonist, D-Lys3-GHRP-6, in rat fundic strips is mediated through 5-HT receptors
    • doi:10.1016/j.ejphar.2006.03.043
    • Depoortere I, Thijs T & Peeters T. The contractile effect of the ghrelin receptor antagonist, D-Lys3-GHRP-6, in rat fundic strips is mediated through 5-HT receptors. European Journal of Pharmacology 2006 537 160-165. (doi:10.1016/j.ejphar.2006.03.043)
    • (2006) European Journal of Pharmacology , vol.537 , pp. 160-165
    • Depoortere, I.1    Thijs, T.2    Peeters, T.3
  • 25
    • 0031445516 scopus 로고    scopus 로고
    • Characterization of the binding of MSH-B, HB-228, GHRP-6 and 153N-6 to the human melanocortin receptor subtypes
    • doi:10.1016/S0143-4179(97)90002-0
    • Schioth HB, Muceniece R & Wikberg JE. Characterization of the binding of MSH-B, HB-228, GHRP-6 and 153N-6 to the human melanocortin receptor subtypes. Neuropeptides 1997 31 565-571. (doi:10.1016/S0143-4179(97)90002-0)
    • (1997) Neuropeptides , vol.31 , pp. 565-571
    • Schioth, H.B.1    Muceniece, R.2    Wikberg, J.E.3
  • 26
    • 4444246201 scopus 로고    scopus 로고
    • Ghrelin and des-acyl ghrelin both inhibit isoproterenol-induced lipolysis in rat adipocytes via a non-type 1a growth hormone secretagogue receptor
    • doi:10.1016/j.ejphar.2004.07.066
    • Muccioli G, Pons N, Ghe C, Catapano F, Granata R & Ghigo E. Ghrelin and des-acyl ghrelin both inhibit isoproterenol-induced lipolysis in rat adipocytes via a non-type 1a growth hormone secretagogue receptor. European Journal of Pharmacology 2004 498 27-35. (doi:10.1016/j.ejphar.2004.07.066)
    • (2004) European Journal of Pharmacology , vol.498 , pp. 27-35
    • Muccioli, G.1    Pons, N.2    Ghe, C.3    Catapano, F.4    Granata, R.5    Ghigo, E.6
  • 27
    • 79955755910 scopus 로고    scopus 로고
    • Acylated and unacylated ghrelin attenuate isoproterenol-induced lipolysis in isolated rat visceral adipocytes through activation of phosphoinositide 3-kinase g and phosphodiesterase 3B
    • doi:10.1016/j.bbalip.2011.03.001
    • Baragli A, Ghe C, Arnoletti E, Granata R, Ghigo E & Muccioli G. Acylated and unacylated ghrelin attenuate isoproterenol-induced lipolysis in isolated rat visceral adipocytes through activation of phosphoinositide 3-kinase g and phosphodiesterase 3B. Biochimica et Biophysica Acta 2011 1811 386-396. (doi:10.1016/j.bbalip.2011.03.001)
    • (2011) Biochimica et Biophysica Acta , vol.1811 , pp. 386-396
    • Baragli, A.1    Ghe, C.2    Arnoletti, E.3    Granata, R.4    Ghigo, E.5    Muccioli, G.6
  • 29
    • 58949092112 scopus 로고    scopus 로고
    • Des-acyl ghrelin fragments evoke endothelium-dependent vasodilatation of rat mesenteric vascular bed via activation of potassium channels
    • doi:10.1016/j.ejphar.2008.10.032
    • Moazed B, Quest D & Gopalakrishnan V. Des-acyl ghrelin fragments evoke endothelium-dependent vasodilatation of rat mesenteric vascular bed via activation of potassium channels. European Journal of Pharmacology 2009 604 79-86. (doi:10.1016/j.ejphar.2008.10.032)
    • (2009) European Journal of Pharmacology , vol.604 , pp. 79-86
    • Moazed, B.1    Quest, D.2    Gopalakrishnan, V.3
  • 30
    • 10844287775 scopus 로고    scopus 로고
    • Stomach regulates energy balance via acylated ghrelin and desacyl ghrelin
    • doi:10.1136/gut.2004.038737
    • Asakawa A, Inui A, Fujimiya M, Sakamaki R, Shinfuku N, Ueta Y, Meguid MM & Kasuga M. Stomach regulates energy balance via acylated ghrelin and desacyl ghrelin. Gut 2005 54 18-24. (doi:10.1136/gut.2004.038737)
    • (2005) Gut , vol.54 , pp. 18-24
    • Asakawa, A.1    Inui, A.2    Fujimiya, M.3    Sakamaki, R.4    Shinfuku, N.5    Ueta, Y.6    Meguid, M.M.7    Kasuga, M.8
  • 31
    • 50449085374 scopus 로고    scopus 로고
    • Effect of desacyl ghrelin on adiposity and glucose metabolism
    • doi:10.1210/en.2008-0263
    • Zhang W, Chai B, Li JY, Wang H & Mulholland MW. Effect of desacyl ghrelin on adiposity and glucose metabolism. Endocrinology 2008 149 4710-4716. (doi:10.1210/en.2008-0263)
    • (2008) Endocrinology , vol.149 , pp. 4710-4716
    • Zhang, W.1    Chai, B.2    Li, J.Y.3    Wang, H.4    Mulholland, M.W.5
  • 32
    • 76749118930 scopus 로고    scopus 로고
    • Ectopic recombination in the central and peripheral nervous system by aP2/FABP4-Cre mice: Implications for metabolism research
    • doi:10.1016/j.febslet.2010.01.061
    • Martens K, Bottelbergs A & Baes M. Ectopic recombination in the central and peripheral nervous system by aP2/FABP4-Cre mice: implications for metabolism research. FEBS Letters 2010 584 1054-1058. (doi:10.1016/j.febslet. 2010.01.061)
    • (2010) FEBS Letters , vol.584 , pp. 1054-1058
    • Martens, K.1    Bottelbergs, A.2    Baes, M.3
  • 37
    • 33646582986 scopus 로고    scopus 로고
    • Unacylated ghrelin is active on the INS-1E rat insulinoma cell line independently of the growth hormone secretagogue receptor type 1a and the corticotropin releasing factor 2 receptor
    • doi:10.1016/j.mce.2006.03.040
    • Gauna C, Delhanty PJ, van Aken MO, Janssen JA, Themmen AP, Hofland LJ, Culler M, Broglio F, Ghigo E & van der Lely AJ. Unacylated ghrelin is active on the INS-1E rat insulinoma cell line independently of the growth hormone secretagogue receptor type 1a and the corticotropin releasing factor 2 receptor. Molecular and Cellular Endocrinology 2006 251 103-111. (doi:10.1016/j.mce.2006. 03.040)
    • (2006) Molecular and Cellular Endocrinology , vol.251 , pp. 103-111
    • Gauna, C.1    Delhanty, P.J.2    Van Aken, M.O.3    Janssen, J.A.4    Themmen, A.P.5    Hofland, L.J.6    Culler, M.7    Broglio, F.8    Ghigo, E.9    Van Der Lely, A.J.10
  • 38
    • 27344437877 scopus 로고    scopus 로고
    • A novel growth hormone secretagogue-1a receptor antagonist that blocks ghrelin-induced growth hormone secretion but induces increased body weight gain
    • doi:10.1159/000088796
    • Halem HA, Taylor JE, Dong JZ, Shen Y, Datta R, Abizaid A, Diano S, Horvath TL & Culler MD. A novel growth hormone secretagogue-1a receptor antagonist that blocks ghrelin-induced growth hormone secretion but induces increased body weight gain. Neuroendocrinology 2005 81 339-349. (doi:10.1159/000088796)
    • (2005) Neuroendocrinology , vol.81 , pp. 339-349
    • Halem, H.A.1    Taylor, J.E.2    Dong, J.Z.3    Shen, Y.4    Datta, R.5    Abizaid, A.6    Diano, S.7    Horvath, T.L.8    Culler, M.D.9
  • 39
    • 22344435662 scopus 로고    scopus 로고
    • Des-acyl ghrelin acts by CRF type 2 receptors to disrupt fasted stomach motility in conscious rats
    • doi:10.1053/j.gastro.2005.04.015
    • Chen CY, Inui A, Asakawa A, Fujino K, Kato I, Chen CC, Ueno N & Fujimiya M. Des-acyl ghrelin acts by CRF type 2 receptors to disrupt fasted stomach motility in conscious rats. Gastroenterology 2005 129 8-25. (doi:10.1053/j.gastro.2005.04.015)
    • (2005) Gastroenterology , vol.129 , pp. 8-25
    • Chen, C.Y.1    Inui, A.2    Asakawa, A.3    Fujino, K.4    Kato, I.5    Chen, C.C.6    Ueno, N.7    Fujimiya, M.8
  • 40
    • 84857138764 scopus 로고    scopus 로고
    • Des-acyl ghrelin exhibits pro-anabolic and anti-catabolic effects on C2C12 myotubes exposed to cytokines and reduces burn-induced muscle proteolysis in rats
    • doi:10.1016/j.mce.2011.12.021
    • Sheriff S, Kadeer N, Joshi R, Friend LA, James JH & Balasubramaniam A. Des-acyl ghrelin exhibits pro-anabolic and anti-catabolic effects on C2C12 myotubes exposed to cytokines and reduces burn-induced muscle proteolysis in rats. Molecular and Cellular Endocrinology 2012 351 286-295. (doi:10.1016/j.mce.2011.12.021)
    • (2012) Molecular and Cellular Endocrinology , vol.351 , pp. 286-295
    • Sheriff, S.1    Kadeer, N.2    Joshi, R.3    Friend, L.A.4    James, J.H.5    Balasubramaniam, A.6
  • 42
    • 84859591097 scopus 로고    scopus 로고
    • Plasma ghrelin levels are closely associated with severity and morphology of angiographically-detected coronary atherosclerosis in Chineses patients with diabetes mellitus
    • doi:10.1038/aps.2011.196
    • Zhang M, Fang WY, Yuan F, Qu XK, Liu H, Xu YJ, Chen H, Yu YF, Shen Y & Zheng ZC. Plasma ghrelin levels are closely associated with severity and morphology of angiographically-detected coronary atherosclerosis in Chineses patients with diabetes mellitus. Acta Pharmacologica Sinica 2012 33 452-458. (doi:10.1038/aps.2011.196)
    • (2012) Acta Pharmacologica Sinica , vol.33 , pp. 452-458
    • Zhang, M.1    Fang, W.Y.2    Yuan, F.3    Qu, X.K.4    Liu, H.5    Xu, Y.J.6    Chen, H.7    Yu, Y.F.8    Shen, Y.9    Zheng, Z.C.10
  • 43
    • 84861082286 scopus 로고    scopus 로고
    • Ghrelin protects H9c2 cardiomyocytes from angiotensin II-induced apoptosis through the endoplasmic reticulum stress pathway
    • doi:10.1097/FJC.0b013e31824a7b60
    • Yang C,Wang Y, Liu H, Li N, Sun Y, Zhonghui L & Ping Y. Ghrelin protects H9c2 cardiomyocytes from angiotensin II-induced apoptosis through the endoplasmic reticulum stress pathway. Journal of Cardiovascular Pharmacology 2012 59 465-471. (doi:10.1097/FJC.0b013e31824a7b60)
    • (2012) Journal of Cardiovascular Pharmacology , vol.59 , pp. 465-471
    • Yang, C.1    Wang, Y.2    Liu, H.3    Li, N.4    Sun, Y.5    Zhonghui, L.6    Ping, Y.7
  • 45
    • 84859420695 scopus 로고    scopus 로고
    • Ghrelin: An emerging new anticonvulsant neuropeptide
    • doi:10.1111/j.1528-1167.2012.03423.x
    • Portelli J, Michotte Y & Smolders I. Ghrelin: an emerging new anticonvulsant neuropeptide. Epilepsia 2012 53 585-595. (doi:10.1111/j.1528- 1167.2012.03423.x)
    • (2012) Epilepsia , vol.53 , pp. 585-595
    • Portelli, J.1    Michotte, Y.2    Smolders, I.3
  • 46
    • 35648974703 scopus 로고    scopus 로고
    • Ghrelin and reproduction: Ghrelin as novel regulator of the gonadotropic axis
    • doi:10.1016/S0083-6729(06)77012-1
    • Tena-Sempere M. Ghrelin and reproduction: ghrelin as novel regulator of the gonadotropic axis. Vitamins and Hormones 2007 77 285-300. (doi:10.1016/S0083-6729(06)77012-1)
    • (2007) Vitamins and Hormones , vol.77 , pp. 285-300
    • Tena-Sempere, M.1
  • 47
    • 56649102174 scopus 로고    scopus 로고
    • Ghrelin as a pleotrophic modulator of gonadal function and reproduction
    • doi:10.1038/ncpendmet1003
    • Tena-Sempere M. Ghrelin as a pleotrophic modulator of gonadal function and reproduction. Nature Clinical Practice. Endocrinology and Metabolism 2008 4 666-674. (doi:10.1038/ncpendmet1003)
    • (2008) Nature Clinical Practice. Endocrinology and Metabolism , vol.4 , pp. 666-674
    • Tena-Sempere, M.1
  • 49
    • 80053339023 scopus 로고    scopus 로고
    • Lack of direct effects of acyl ghrelin, des-acyl ghrelin, and obestatin on rat lower esophageal sphincter motility in vitro
    • doi:10.1016/j.jcma.2011.08.003
    • Chen CY & Huang SC. Lack of direct effects of acyl ghrelin, des-acyl ghrelin, and obestatin on rat lower esophageal sphincter motility in vitro. Journal of the Chinese Medical Association 2011 74 394-399. (doi:10.1016/j.jcma. 2011.08.003)
    • (2011) Journal of the Chinese Medical Association , vol.74 , pp. 394-399
    • Chen, C.Y.1    Huang, S.C.2
  • 50
    • 79953115619 scopus 로고    scopus 로고
    • Ghrelin: A gut hormonal basis of motility regulation and functional dyspepsia
    • doi:10.1111/j.1440-1746.2011.06630.x
    • Ogiso K, Asakawa A, Amitani H & Inui A. Ghrelin: a gut hormonal basis of motility regulation and functional dyspepsia. Journal of Gastroenterology and Hepatology 2011 26 (Suppl 3) 67-72. (doi:10.1111/j.1440-1746.2011.06630.x)
    • (2011) Journal of Gastroenterology and Hepatology , vol.26 , Issue.SUPPL. 3 , pp. 67-72
    • Ogiso, K.1    Asakawa, A.2    Amitani, H.3    Inui, A.4
  • 53
    • 84859746019 scopus 로고    scopus 로고
    • Expression of ghrelin is correlated to a favorable outcome in invasive breast cancer
    • doi:10.3109/0284186X.2011.631576
    • Gronberg M, Fjallskog ML, Jirstrom K & Janson ET. Expression of ghrelin is correlated to a favorable outcome in invasive breast cancer. Acta Oncologica 2012 51 386-393. (doi:10.3109/0284186X.2011.631576)
    • (2012) Acta Oncologica , vol.51 , pp. 386-393
    • Gronberg, M.1    Fjallskog, M.L.2    Jirstrom, K.3    Janson, E.T.4


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