Peptide-based activation of alpha5 integrin for promoting osteogenesis

Journal of Cellular Biochemistry

Volumn 113, Issue 9, 2012, Pages 3029-3038

  Fromigué, Olivia ^a,b   Brun, Julia ^a,b   Marty, Caroline ^a,b   Da Nascimento, Sophie ^c   Sonnet, Pascal ^c   Marie, Pierre J ^a,b  

^a HÔPITAL LARIBOISIÈRE   (France)

^b UNIVERSITÉ PARIS DESCARTES   (France)

^c UNIVERSITÉ DE PICARDIE JULES VERNE   (France)

Author keywords

bone formation; Integrin ALPHA5; osteoblast; signaling

Indexed keywords

ALPHA5 INTEGRIN; COLLAGEN TYPE 1; CYCLOPEPTIDE; FOCAL ADHESION KINASE; GA CRRETAWAC GA; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; RECOMBINANT BONE MORPHOGENETIC PROTEIN 2; TRANSCRIPTION FACTOR RUNX2; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; APOPTOSIS; ARTICLE; BONE DEVELOPMENT; BONE MINERALIZATION; CELL ADHESION; CELL DIFFERENTIATION; CELL DIVISION; CELL FUNCTION; CELL PROTECTION; CONTROLLED STUDY; EXTRACELLULAR MATRIX; GENE EXPRESSION; IN VITRO STUDY; IN VIVO STUDY; MESENCHYME CELL; MORPHOMETRICS; MOUSE; NONHUMAN; OSSIFICATION; OSTEOBLAST; PRIORITY JOURNAL; SKULL; STEM CELL;

ANIMALS; BLOTTING, WESTERN; CELL ADHESION; CELL PROLIFERATION; INTEGRIN ALPHA5; MICE; OSTEOGENESIS; PEPTIDES, CYCLIC; REAL-TIME POLYMERASE CHAIN REACTION;

MURINAE;

EID: 84863661874     PISSN: 07302312     EISSN: 10974644     Source Type: Journal    
DOI: 10.1002/jcb.24181     Document Type: Article

References (48)

1. Almeida M, Han L, Bellido T, Manolagas SC, Kousteni S,. 2005. Wnt proteins prevent apoptosis of both uncommitted osteoblast progenitors and differentiated osteoblasts by beta-catenin-dependent and -independent signaling cascades involving Src/ERK and phosphatidylinositol 3-kinase/AKT. J Biol Chem 280: 41342-41351.
2. Aubin JE,. 1998. Bone stem cells. J Cell Biochem (Suppl 30-31): 73-82.
3. Aubin JE,. 2001. Regulation of osteoblast formation and function. Rev Endocr Metab Disord 2: 81-94.
4. Bianco P, Riminucci M, Gronthos S, Robey PG,. 2001. Bone marrow stromal stem cells: Nature, biology, and potential applications. Stem Cells 19: 180-192.
5. Cao Z, Huang K, Horwitz AF,. 1998. Identification of a domain on the integrin alpha5 subunit implicated in cell spreading and signaling. J Biol Chem 273: 31670-31679.
6. Chen D, Zhao M, Mundy GR,. 2004. Bone morphogenetic proteins. Growth Factors 22: 233-241.
7. Dufour C, Guénou H, Kaabeche K, Bouvard D, Sanjay A, Marie PJ,. 2008a. FGFR2-Cbl interaction in lipid rafts triggers attenuation of PI3K/Akt signaling and osteoblast survival. Bone 42: 1032-1039.
8. Dufour C, Holy X, Marie PJ,. 2008b. Transforming growth factor-beta prevents osteoblast apoptosis induced by skeletal unloading via PI3K/Akt, Bcl-2, and phospho-Bad signaling. Am J Physiol Endocrinol Metab 294: E794-E801.
9. Franceschi RT,. 1999. The developmental control of osteoblast-specific gene expression: Role of specific transcription factors and the extracellular matrix environment. Crit Rev Oral Biol Med 10: 40-57.
10. Ge C, Yang Q, Zhao G, Yu H, Kirkwood KL, Franceschi RT,. 2011. Interactions between extracellular signal-regulated kinase 1/2 and P38 map kinase pathways in the control of RUNX2 phosphorylation and transcriptional activity. J Bone Miner Res 27: 538-551.
11. Giancotti FG,. 1997. Integrin signaling: Specificity and control of cell survival and cell cycle progression. Curr Opin Cell Biol 9: 691-700.
12. Grossmann J,. 2002. Molecular mechanisms of "detachment-induced apoptosis-Anoikis ". Apoptosis 7: 247-260.
13. Hamidouche Z, Fromigué O, Ringe J, Haüpl T, Vaudin P, Pages JC, Srouji S, Livne E, Marie PJ,. 2009. Priming integrin alpha5 promotes human mesenchymal stromal cell osteoblast differentiation and osteogenesis. Proc Natl Acad Sci USA 106: 18587-18591.
14. Hamidouche Z, Fromigué O, Ringe J, Haupl T, Marie PJ,. 2010. Crosstalks between integrin alpha 5 and IGF2/IGFBP2 signalling trigger human bone marrow-derived mesenchymal stromal osteogenic differentiation. BMC Cell Biol 11: 44.
15. Howe AK, Aplin AE, Juliano RL,. 2002. Anchorage-dependent ERK signaling-mechanisms and consequences. Curr Opin Genet Dev 12: 30-35.
16. Hynes RO,. 2002. Integrins: Bidirectional, allosteric signaling machines. Cell 110: 673-687.
17. Jaiswal RK, Jaiswal N, Bruder SP, Mbalaviele G, Marshak DR, Pittenger MF,. 2000. Adult human mesenchymal stem cell differentiation to the osteogenic or adipogenic lineage is regulated by mitogen-activated protein kinase. J Biol Chem 275: 9645-9652.
18. Kaabeche K, Guénou H, Bouvard D, Didelot N, Listrat A, Marie PJ,. 2005. Cbl-mediated ubiquitination of alpha5 integrin subunit mediates fibronectin-dependent osteoblast detachment and apoptosis induced by FGFR2 activation. J Cell Sci 118: 1223-1232.
19. Karsenty G, Wagner EF,. 2002. Reaching a genetic and molecular understanding of skeletal development. Dev Cell 2: 389-406.
20. Kassem M,. 2004. Mesenchymal stem cells: Biological characteristics and potential clinical applications. Cloning Stem Cells 6: 369-374.
21. Khosla S, Riggs BL,. 2005. Pathophysiology of age-related bone loss and osteoporosis. Endocrinol Metab Clin North Am 34: 1015-1030, xi.
22. Koivunen E, Wang B, Ruoslahti E,. 1994. Isolation of a highly specific ligand for the alpha 5 beta 1 integrin from a phage display library. J Cell Biol 124: 373-380.
23. Lian JB, Javed A, Zaidi SK, Lengner C, Montecino M, van Wijnen AJ, Stein JL, Stein GS,. 2004. Regulatory controls for osteoblast growth and differentiation: Role of Runx/Cbfa/AML factors. Crit Rev Eukaryot Gene Expr 14: 1-41.
24. Manolagas SC,. 2000. Birth and death of bone cells: Basic regulatory mechanisms and implications for the pathogenesis and treatment of osteoporosis. Endocr Rev 21: 115-137.
25. Marie PJ,. 2009. Bone cell-matrix protein interactions. Osteoporos Int 20: 1037-1042.
26. Marie PJ, Fromigué O,. 2006. Osteogenic differentiation of human marrow-derived mesenchymal stem cells. Regen Med 1: 539-548.
27. Marie PJ, Kassem M,. 2011a. Extrinsic mechanisms involved in age-related defective bone formation. J Clin Endocrinol Metab. 96: 600-609.
28. Marie PJ, Kassem M,. 2011b. Osteoblasts in osteoporosis: Past, emerging and future anabolic targets. Eur J Endocrinol 165: 1-10.
29. Matter ML, Ruoslahti E,. 2001. A signaling pathway from the alpha5beta1 and alpha(v)beta3 integrins that elevates bcl-2 transcription. J Biol Chem 276: 27757-27763.
30. Meredith JE Jr, Fazeli B, Schwartz MA,. 1993. The extracellular matrix as a cell survival factor. Mol Biol Cell 4: 953-961.
31. Mould AP, Burrows L, Humphries MJ,. 1998. Identification of amino acid residues that form part of the ligand-binding pocket of integrin alpha5 beta1. J Biol Chem 273: 25664-25672.
32. Mould AP, Askari JA, Humphries MJ,. 2000. Molecular basis of ligand recognition by integrin alpha 5beta 1. I. Specificity of ligand binding is determined by amino acid sequences in the second and third NH2-terminal repeats of the alpha subunit. J Biol Chem 275: 20324-20336.
33. Mould AP, Koper EJ, Byron A, Zahn G, Humphries MJ,. 2009. Mapping the ligand-binding pocket of integrin alpha5beta1 using a gain-of-function approach. Biochem J 424: 179-189.
34. Moursi AM, Damsky CH, Lull J, Zimmerman D, Doty SB, Aota S, Globus RK,. 1996. Fibronectin regulates calvarial osteoblast differentiation. J Cell Sci 109 (Pt 6): 1369-1380.
35. Moursi AM, Globus RK, Damsky CH,. 1997. Interactions between integrin receptors and fibronectin are required for calvarial osteoblast differentiation in vitro. J Cell Sci 110 (Pt 18): 2187-2196.
36. Mundy G, Garrett R, Harris S, Chan J, Chen D, Rossini G, Boyce B, Zhao M, Gutierrez G,. 1999. Stimulation of bone formation in vitro and in rodents by statins. Science 286: 1946-1949.
37. Parfitt AM, Drezner MK, Glorieux FH, Kanis JA, Malluche H, Meunier PJ, Ott SM, Recker RR,. 1987. Bone histomorphometry: Standardization of nomenclature, symbols, and units. Report of the ASBMR Histomorphometry Nomenclature Committee. J Bone Miner Res 2: 595-610.
38. Phimphilai M, Zhao Z, Boules H, Roca H, Franceschi RT,. 2006. BMP signaling is required for RUNX2-dependent induction of the osteoblast phenotype. J Bone Miner Res 21: 637-646.
39. Prockop DJ,. 2009. Repair of tissues by adult stem/progenitor cells (MSCs): Controversies, myths, and changing paradigms. Mol Ther 17: 939-946.
40. Pulai JI, Del Carlo M Jr, Loeser RF,. 2002. The alpha5beta1 integrin provides matrix survival signals for normal and osteoarthritic human articular chondrocytes in vitro. Arthritis Rheum 46: 1528-1535.
41. Reginato MJ, Mills KR, Paulus JK, Lynch DK, Sgroi DC, Debnath J, Muthuswamy SK, Brugge JS,. 2003. Integrins and EGFR coordinately regulate the pro-apoptotic protein Bim to prevent anoikis. Nat Cell Biol 5: 733-740.
42. Riggs BL, Parfitt AM,. 2005. Drugs used to treat osteoporosis: The critical need for a uniform nomenclature based on their action on bone remodeling. J Bone Miner Res 20: 177-184.
43. Rosen V,. 2009. BMP2 signaling in bone development and repair. Cytokine Growth Factor Rev 20: 475-480.
44. Ruoslahti E, Reed JC,. 1994. Anchorage dependence, integrins, and apoptosis. Cell 77: 477-478.
45. Salasznyk RM, Klees RF, Williams WA, Boskey A, Plopper GE,. 2007. Focal adhesion kinase signaling pathways regulate the osteogenic differentiation of human mesenchymal stem cells. Exp Cell Res 313: 22-37.
46. Srouji S, Ben-David D, Fromigué O, Vaudin P, Kuhn G, Muller R, Livne E, Marie PJ,. 2012. Lentiviral-mediated integrin alpha5 expression in human adult mesenchymal stromal cells promotes bone repair in mouse cranial and long-bone defects. Hum Gene Ther 23: 167-172.
47. Xiao G, Jiang D, Thomas P, Benson MD, Guan K, Karsenty G, Franceschi RT,. 2000. MAPK pathways activate and phosphorylate the osteoblast-specific transcription factor, Cbfa1. J Biol Chem 275: 4453-4459.
48. Zhang Z, Vuori K, Reed JC, Ruoslahti E,. 1995. The alpha 5 beta 1 integrin supports survival of cells on fibronectin and up-regulates Bcl-2 expression. Proc Natl Acad Sci USA 92: 6161-6165.