-
1
-
-
78149299837
-
Proteasome inhibitors: dozens of molecules and still counting
-
de Bettignies, G. & Coux, O. (2010) Proteasome inhibitors: dozens of molecules and still counting. Biochimie 92, 1530-1545.
-
(2010)
Biochimie
, vol.92
, pp. 1530-1545
-
-
de Bettignies, G.1
Coux, O.2
-
2
-
-
33947659939
-
20S proteasome and its inhibitors: crystallographic knowledge for drug development
-
Borissenko, L. & Groll, M. (2007) 20S proteasome and its inhibitors: crystallographic knowledge for drug development. Chem. Rev. 107, 687-717.
-
(2007)
Chem. Rev.
, vol.107
, pp. 687-717
-
-
Borissenko, L.1
Groll, M.2
-
3
-
-
58249122326
-
Small molecule-mediated disruption of Wnt-dependent signaling in tissue regeneration and cancer
-
Chen, B., Dodge, M.E., Tang, W., Lu, J., Ma, Z., Fan, C.W., Wei, S., Hao, W., Kilgore, J., Williams, N.S., Roth, M.G., Amatruda, J.F., Chen, C. & Lum, L. (2009) Small molecule-mediated disruption of Wnt-dependent signaling in tissue regeneration and cancer. Nat. Chem. Biol. 5, 100-107.
-
(2009)
Nat. Chem. Biol.
, vol.5
, pp. 100-107
-
-
Chen, B.1
Dodge, M.E.2
Tang, W.3
Lu, J.4
Ma, Z.5
Fan, C.W.6
Wei, S.7
Hao, W.8
Kilgore, J.9
Williams, N.S.10
Roth, M.G.11
Amatruda, J.F.12
Chen, C.13
Lum, L.14
-
4
-
-
0032535483
-
The ubiquitin-proteasome pathway: on protein death and cell life
-
Ciechanover, A. (1998) The ubiquitin-proteasome pathway: on protein death and cell life. EMBO J. 17, 7151-7160.
-
(1998)
EMBO J.
, vol.17
, pp. 7151-7160
-
-
Ciechanover, A.1
-
5
-
-
38449099679
-
Role of proteasomes in disease
-
Dahlmann, B. (2007) Role of proteasomes in disease. BMC Biochem. 8(Suppl. 1), S3.
-
(2007)
BMC Biochem.
, vol.8
, Issue.SUPPL. 1
-
-
Dahlmann, B.1
-
6
-
-
77649237033
-
Building on bortezomib: second-generation proteasome inhibitors as anti-cancer therapy
-
Dick, L.R. & Fleming, P.E. (2010) Building on bortezomib: second-generation proteasome inhibitors as anti-cancer therapy. Drug Discov. Today 15, 243-249.
-
(2010)
Drug Discov. Today
, vol.15
, pp. 243-249
-
-
Dick, L.R.1
Fleming, P.E.2
-
7
-
-
0028927556
-
Two distinct osteoblast-specific cis-acting elements control expression of a mouse osteocalcin gene
-
Ducy, P. & Karsenty, G. (1995) Two distinct osteoblast-specific cis-acting elements control expression of a mouse osteocalcin gene. Mol. Cell. Biol. 15, 1858-1869.
-
(1995)
Mol. Cell. Biol.
, vol.15
, pp. 1858-1869
-
-
Ducy, P.1
Karsenty, G.2
-
8
-
-
0030678549
-
Osf2/Cbfa1: a transcriptional activator of osteoblast differentiation
-
Ducy, P., Zhang, R., Geoffroy, V., Ridall, A.L. & Karsenty, G. (1997) Osf2/Cbfa1: a transcriptional activator of osteoblast differentiation. Cell 89, 747-754.
-
(1997)
Cell
, vol.89
, pp. 747-754
-
-
Ducy, P.1
Zhang, R.2
Geoffroy, V.3
Ridall, A.L.4
Karsenty, G.5
-
9
-
-
0038819051
-
Selective inhibitors of the osteoblast proteasome stimulate bone formation in vivo and in vitro
-
Garrett, I.R., Chen, D., Gutierrez, G., Zhao, M., Escobedo, A., Rossini, G., Harris, S.E., Gallwitz, W., Kim, K.B., Hu, S., Crews, C.M. & Mundy, G.R. (2003) Selective inhibitors of the osteoblast proteasome stimulate bone formation in vivo and in vitro. J. Clin. Invest. 111, 1771-1782.
-
(2003)
J. Clin. Invest.
, vol.111
, pp. 1771-1782
-
-
Garrett, I.R.1
Chen, D.2
Gutierrez, G.3
Zhao, M.4
Escobedo, A.5
Rossini, G.6
Harris, S.E.7
Gallwitz, W.8
Kim, K.B.9
Hu, S.10
Crews, C.M.11
Mundy, G.R.12
-
10
-
-
23744498205
-
Myeloma cells block RUNX2/CBFA1 activity in human bone marrow osteoblast progenitors and inhibit osteoblast formation and differentiation
-
Giuliani, N., Colla, S., Morandi, F., Lazzaretti, M., Sala, R., Bonomini, S., Grano, M., Colucci, S., Svaldi, M. & Rizzoli, V. (2005) Myeloma cells block RUNX2/CBFA1 activity in human bone marrow osteoblast progenitors and inhibit osteoblast formation and differentiation. Blood 106, 2472-2483.
-
(2005)
Blood
, vol.106
, pp. 2472-2483
-
-
Giuliani, N.1
Colla, S.2
Morandi, F.3
Lazzaretti, M.4
Sala, R.5
Bonomini, S.6
Grano, M.7
Colucci, S.8
Svaldi, M.9
Rizzoli, V.10
-
11
-
-
34347400592
-
The proteasome inhibitor bortezomib affects osteoblast differentiation in vitro and in vivo in multiple myeloma patients
-
Giuliani, N., Morandi, F., Tagliaferri, S., Lazzaretti, M., Bonomini, S., Crugnola, M., Mancini, C., Martella, E., Ferrari, L., Tabilio, A. & Rizzoli, V. (2007) The proteasome inhibitor bortezomib affects osteoblast differentiation in vitro and in vivo in multiple myeloma patients. Blood 110, 334-338.
-
(2007)
Blood
, vol.110
, pp. 334-338
-
-
Giuliani, N.1
Morandi, F.2
Tagliaferri, S.3
Lazzaretti, M.4
Bonomini, S.5
Crugnola, M.6
Mancini, C.7
Martella, E.8
Ferrari, L.9
Tabilio, A.10
Rizzoli, V.11
-
12
-
-
33746786028
-
Bortezomib increases osteoblast activity in myeloma patients irrespective of response to treatment
-
Heider, U., Kaiser, M., Müller, C., Jakob, C., Zavrski, I., Schulz, C.O., Fleissner, C., Hecht, M. & Sezer, O. (2006) Bortezomib increases osteoblast activity in myeloma patients irrespective of response to treatment. Eur. J. Haematol. 77, 233-238.
-
(2006)
Eur. J. Haematol.
, vol.77
, pp. 233-238
-
-
Heider, U.1
Kaiser, M.2
Müller, C.3
Jakob, C.4
Zavrski, I.5
Schulz, C.O.6
Fleissner, C.7
Hecht, M.8
Sezer, O.9
-
13
-
-
33744454653
-
Regulation of adult bone mass by the zinc finger adapter protein Schnurri-3
-
Jones, D.C., Wein, M.N., Oukka, M., Hofstaetter, J.G., Glimcher, M.J. & Glimcher, L.H. (2006) Regulation of adult bone mass by the zinc finger adapter protein Schnurri-3. Science 312, 1223-1227.
-
(2006)
Science
, vol.312
, pp. 1223-1227
-
-
Jones, D.C.1
Wein, M.N.2
Oukka, M.3
Hofstaetter, J.G.4
Glimcher, M.J.5
Glimcher, L.H.6
-
14
-
-
0036732838
-
Identification of a BMP-responsive element in Id1, the gene for inhibition of myogenesis
-
Katagiri, T., Imada, M., Yanai, T., Suda, T., Takahashi, N. & Kamijo, R. (2002) Identification of a BMP-responsive element in Id1, the gene for inhibition of myogenesis. Genes Cells 7, 949-960.
-
(2002)
Genes Cells
, vol.7
, pp. 949-960
-
-
Katagiri, T.1
Imada, M.2
Yanai, T.3
Suda, T.4
Takahashi, N.5
Kamijo, R.6
-
15
-
-
0027946689
-
Bone morphogenetic protein-2 converts the differentiation pathway of C2C12 myoblasts into the osteoblast lineage
-
Katagiri, T., Yamaguchi, A., Komaki, M., Abe, E., Takahashi, N., Ikeda, T., Rosen, V., Wozney, J., Fujisawa-Sehara, A. & Suda, T. (1994) Bone morphogenetic protein-2 converts the differentiation pathway of C2C12 myoblasts into the osteoblast lineage. J. Cell Biol. 127, 1755-1766.
-
(1994)
J. Cell Biol.
, vol.127
, pp. 1755-1766
-
-
Katagiri, T.1
Yamaguchi, A.2
Komaki, M.3
Abe, E.4
Takahashi, N.5
Ikeda, T.6
Rosen, V.7
Wozney, J.8
Fujisawa-Sehara, A.9
Suda, T.10
-
16
-
-
0342467925
-
ATF4 degradation relies on a phosphorylation-dependent interaction with the SCF(betaTrCP) ubiquitin ligase
-
Lassot, I., Ségéral, E., Berlioz-Torrent, C., Durand, H., Groussin, L., Hai, T., Benarous, R. & Margottin-Goguet, F. (2001) ATF4 degradation relies on a phosphorylation-dependent interaction with the SCF(betaTrCP) ubiquitin ligase. Mol. Cell. Biol. 21, 2192-2202.
-
(2001)
Mol. Cell. Biol.
, vol.21
, pp. 2192-2202
-
-
Lassot, I.1
Ségéral, E.2
Berlioz-Torrent, C.3
Durand, H.4
Groussin, L.5
Hai, T.6
Benarous, R.7
Margottin-Goguet, F.8
-
17
-
-
67650230896
-
Wnt/beta-catenin signaling: components, mechanisms, and diseases
-
MacDonald, B., Tamai, K. & He, X. (2009) Wnt/beta-catenin signaling: components, mechanisms, and diseases. Dev. Cell 17, 9-26.
-
(2009)
Dev. Cell
, vol.17
, pp. 9-26
-
-
MacDonald, B.1
Tamai, K.2
He, X.3
-
18
-
-
0037167519
-
Id: a target of BMP signaling
-
Miyazono, K. & Miyazawa, K. (2002) Id: a target of BMP signaling. Sci. STKE 2002, PE40.
-
(2002)
Sci. STKE
, vol.2002
-
-
Miyazono, K.1
Miyazawa, K.2
-
19
-
-
38849130851
-
Pharmacologic targeting of a stem/progenitor population in vivo is associated with enhanced bone regeneration in mice
-
Mukherjee, S., Raje, N., Schoonmaker, J.A. et al. (2008) Pharmacologic targeting of a stem/progenitor population in vivo is associated with enhanced bone regeneration in mice. J. Clin. Invest. 118, 491-504.
-
(2008)
J. Clin. Invest.
, vol.118
, pp. 491-504
-
-
Mukherjee, S.1
Raje, N.2
Schoonmaker, J.A.3
-
20
-
-
27844541752
-
Cross-talk between Wnt and bone morphogenetic protein 2 (BMP-2) signaling in differentiation pathway of C2C12 myoblasts
-
Nakashima, A., Katagiri, T. & Tamura, M. (2005) Cross-talk between Wnt and bone morphogenetic protein 2 (BMP-2) signaling in differentiation pathway of C2C12 myoblasts. J. Biol. Chem. 280, 37660-37668.
-
(2005)
J. Biol. Chem.
, vol.280
, pp. 37660-37668
-
-
Nakashima, A.1
Katagiri, T.2
Tamura, M.3
-
21
-
-
0030997581
-
Identification of the domain of alpha-catenin involved in its association with beta-catenin and plakoglobin (gamma-catenin)
-
Obama, H. & Ozawa, M. (1997) Identification of the domain of alpha-catenin involved in its association with beta-catenin and plakoglobin (gamma-catenin). J. Biol. Chem. 272, 11017-11020.
-
(1997)
J. Biol. Chem.
, vol.272
, pp. 11017-11020
-
-
Obama, H.1
Ozawa, M.2
-
22
-
-
53049106912
-
Molecular basis of bortezomib resistance: proteasome subunit beta5 (PSMB5) gene mutation and overexpression of PSMB5 protein
-
Oerlemans, R., Franke, N.E., Assaraf, Y.G., et al. (2008) Molecular basis of bortezomib resistance: proteasome subunit beta5 (PSMB5) gene mutation and overexpression of PSMB5 protein. Blood 112, 2489-2499.
-
(2008)
Blood
, vol.112
, pp. 2489-2499
-
-
Oerlemans, R.1
Franke, N.E.2
Assaraf, Y.G.3
-
23
-
-
34848853850
-
Stimulation of new bone formation by the proteasome inhibitor, bortezomib: implications for myeloma bone disease
-
Oyajobi, B.O., Garrett, I.R., Gupta, A., Flores, A., Esparza, J., Muñoz, S., Zhao, M. & Mundy, G.R. (2007) Stimulation of new bone formation by the proteasome inhibitor, bortezomib: implications for myeloma bone disease. Br. J. Haematol. 139, 434-438.
-
(2007)
Br. J. Haematol.
, vol.139
, pp. 434-438
-
-
Oyajobi, B.O.1
Garrett, I.R.2
Gupta, A.3
Flores, A.4
Esparza, J.5
Muñoz, S.6
Zhao, M.7
Mundy, G.R.8
-
24
-
-
58149478516
-
The proteasome inhibitor, bortezomib suppresses primary myeloma and stimulates bone formation in myelomatous and nonmyelomatous bones in vivo
-
Pennisi, A., Li, X., Ling, W., Khan, S., Zangari, M. & Yaccoby, S. (2009) The proteasome inhibitor, bortezomib suppresses primary myeloma and stimulates bone formation in myelomatous and nonmyelomatous bones in vivo. Am. J. Hematol. 84, 6-14.
-
(2009)
Am. J. Hematol.
, vol.84
, pp. 6-14
-
-
Pennisi, A.1
Li, X.2
Ling, W.3
Khan, S.4
Zangari, M.5
Yaccoby, S.6
-
25
-
-
60849091616
-
Bone morphogenetic protein-2 enhances Wnt/beta-catenin signaling-induced osteoprotegerin expression
-
Sato, M., Nakashima, A., Nashimoto, M., Yawaka, Y. & Tamura, M. (2009a) Bone morphogenetic protein-2 enhances Wnt/beta-catenin signaling-induced osteoprotegerin expression. Genes Cells 14, 141-153.
-
(2009)
Genes Cells
, vol.14
, pp. 141-153
-
-
Sato, M.1
Nakashima, A.2
Nashimoto, M.3
Yawaka, Y.4
Tamura, M.5
-
26
-
-
64949115943
-
Bone morphogenetic protein-2 down-regulates miR-206 expression by blocking its maturation process
-
Sato, M., Nashimoto, M., Katagiri, T., Yawaka, Y. & Tamura, M. (2009b) Bone morphogenetic protein-2 down-regulates miR-206 expression by blocking its maturation process. Biochem. Biophys. Res. Commun. 383, 125-129.
-
(2009)
Biochem. Biophys. Res. Commun.
, vol.383
, pp. 125-129
-
-
Sato, M.1
Nashimoto, M.2
Katagiri, T.3
Yawaka, Y.4
Tamura, M.5
-
27
-
-
61449156563
-
Targeting proteins for destruction by the ubiquitin system: implications for human pathobiology
-
Schwartz, A.L. & Ciechanover, A. (2009) Targeting proteins for destruction by the ubiquitin system: implications for human pathobiology. Annu. Rev. Pharmacol. Toxicol. 49, 73-96.
-
(2009)
Annu. Rev. Pharmacol. Toxicol.
, vol.49
, pp. 73-96
-
-
Schwartz, A.L.1
Ciechanover, A.2
-
28
-
-
70450227260
-
Proteasome inhibitors in the treatment of multiple myeloma
-
Shah, J.J. & Orlowski, R.Z. (2009) Proteasome inhibitors in the treatment of multiple myeloma. Leukemia 23, 1964-1979.
-
(2009)
Leukemia
, vol.23
, pp. 1964-1979
-
-
Shah, J.J.1
Orlowski, R.Z.2
-
29
-
-
33646808104
-
Wnt signalling in osteoblasts regulates expression of the receptor activator of NFkappaB ligand and inhibits osteoclastogenesis in vitro
-
Spencer, G., Utting, J., Etheridge, S., Arnett, T. & Genever, P. (2006) Wnt signalling in osteoblasts regulates expression of the receptor activator of NFkappaB ligand and inhibits osteoclastogenesis in vitro. J. Cell Sci. 119, 1283-1296.
-
(2006)
J. Cell Sci.
, vol.119
, pp. 1283-1296
-
-
Spencer, G.1
Utting, J.2
Etheridge, S.3
Arnett, T.4
Genever, P.5
-
30
-
-
77957329671
-
Role of the Wnt signaling pathway in bone and tooth
-
Tamura, M., Nemoto, E., Sato, M.M., Nakashima, A. & Shimauchi, H. (2010) Role of the Wnt signaling pathway in bone and tooth. Front. Biosci. (Elite Ed.) 2, 1405-1413.
-
(2010)
Front. Biosci. (Elite Ed.)
, vol.2
, pp. 1405-1413
-
-
Tamura, M.1
Nemoto, E.2
Sato, M.M.3
Nakashima, A.4
Shimauchi, H.5
-
32
-
-
77952714029
-
Smurf control in bone cells
-
Xing, L., Zhang, M. & Chen, D. (2010) Smurf control in bone cells. J. Cell. Biochem. 110, 554-563.
-
(2010)
J. Cell. Biochem.
, vol.110
, pp. 554-563
-
-
Xing, L.1
Zhang, M.2
Chen, D.3
-
33
-
-
17044414102
-
Ubiquitin ligase Smurf1 controls osteoblast activity and bone homeostasis by targeting MEKK2 for degradation
-
Yamashita, M., Ying, S.X., Zhang, G.M., Li, C., Cheng, S.Y., Deng, C.X. & Zhang, Y.E. (2005) Ubiquitin ligase Smurf1 controls osteoblast activity and bone homeostasis by targeting MEKK2 for degradation. Cell 121, 101-113.
-
(2005)
Cell
, vol.121
, pp. 101-113
-
-
Yamashita, M.1
Ying, S.X.2
Zhang, G.M.3
Li, C.4
Cheng, S.Y.5
Deng, C.X.6
Zhang, Y.E.7
-
34
-
-
11144357428
-
ATF4 is a substrate of RSK2 and an essential regulator of osteoblast biology; implication for Coffin-Lowry Syndrome
-
Yang, X., Matsuda, K., Bialek, P., Jacquot, S., Masuoka, H.C., Schinke, T., Li, L., Brancorsini, S., Sassone-Corsi, P., Townes, T.M., Hanauer, A. & Karsenty, G. (2004) ATF4 is a substrate of RSK2 and an essential regulator of osteoblast biology; implication for Coffin-Lowry Syndrome. Cell 117, 387-398.
-
(2004)
Cell
, vol.117
, pp. 387-398
-
-
Yang, X.1
Matsuda, K.2
Bialek, P.3
Jacquot, S.4
Masuoka, H.C.5
Schinke, T.6
Li, L.7
Brancorsini, S.8
Sassone-Corsi, P.9
Townes, T.M.10
Hanauer, A.11
Karsenty, G.12
-
35
-
-
37249010753
-
Dorsomorphin inhibits BMP signals required for embryogenesis and iron metabolism
-
Yu, P.B., Hong, C.C., Sachidanandan, C., Babitt, J.L., Deng, D.Y., Hoyng, S.A., Lin, H.Y., Bloch, K.D. & Peterson, R.T. (2008a) Dorsomorphin inhibits BMP signals required for embryogenesis and iron metabolism. Nat. Chem. Biol. 4, 33-41.
-
(2008)
Nat. Chem. Biol.
, vol.4
, pp. 33-41
-
-
Yu, P.B.1
Hong, C.C.2
Sachidanandan, C.3
Babitt, J.L.4
Deng, D.Y.5
Hoyng, S.A.6
Lin, H.Y.7
Bloch, K.D.8
Peterson, R.T.9
-
36
-
-
41949123120
-
General transcription factor IIA-gamma increases osteoblast-specific osteocalcin gene expression via activating transcription factor 4 and runt-related transcription factor 2
-
Yu, S., Jiang, Y., Galson, D.L., Luo, M., Lai, Y., Lu, Y., Ouyang, H.J., Zhang, J. & Xiao, G. (2008b) General transcription factor IIA-gamma increases osteoblast-specific osteocalcin gene expression via activating transcription factor 4 and runt-related transcription factor 2. J. Biol. Chem. 283, 5542-5553.
-
(2008)
J. Biol. Chem.
, vol.283
, pp. 5542-5553
-
-
Yu, S.1
Jiang, Y.2
Galson, D.L.3
Luo, M.4
Lai, Y.5
Lu, Y.6
Ouyang, H.J.7
Zhang, J.8
Xiao, G.9
-
37
-
-
1842477311
-
Smurf1 inhibits osteoblast differentiation and bone formation in vitro and in vivo
-
Zhao, M., Qiao, M., Harris, S.E., Oyajobi, B.O., Mundy, G.R. & Chen, D. (2004) Smurf1 inhibits osteoblast differentiation and bone formation in vitro and in vivo. J. Biol. Chem. 279, 12854-12859.
-
(2004)
J. Biol. Chem.
, vol.279
, pp. 12854-12859
-
-
Zhao, M.1
Qiao, M.2
Harris, S.E.3
Oyajobi, B.O.4
Mundy, G.R.5
Chen, D.6
-
38
-
-
0041845297
-
E3 ubiquitin ligase Smurf1 mediates core-binding factor alpha1/Runx2 degradation and plays a specific role in osteoblast differentiation
-
Zhao, M., Qiao, M., Oyajobi, B.O., Mundy, G.R. & Chen, D. (2003) E3 ubiquitin ligase Smurf1 mediates core-binding factor alpha1/Runx2 degradation and plays a specific role in osteoblast differentiation. J. Biol. Chem. 278, 27939-27944.
-
(2003)
J. Biol. Chem.
, vol.278
, pp. 27939-27944
-
-
Zhao, M.1
Qiao, M.2
Oyajobi, B.O.3
Mundy, G.R.4
Chen, D.5
-
39
-
-
0033549789
-
A SMAD ubiquitin ligase targets the BMP pathway and affects embryonic pattern formation
-
Zhu, H., Kavsak, P., Abdollah, S., Wrana, J.L. & Thomsen, G.H. (1999) A SMAD ubiquitin ligase targets the BMP pathway and affects embryonic pattern formation. Nature 400, 687-693.
-
(1999)
Nature
, vol.400
, pp. 687-693
-
-
Zhu, H.1
Kavsak, P.2
Abdollah, S.3
Wrana, J.L.4
Thomsen, G.H.5
|