Prolonged ectopic calcification induced by BMP-2-derived synthetic peptide

Journal of Biomedical Materials Research - Part A

Volumn 70, Issue 1, 2004, Pages 115-121

  Saito, Atsuhiro ^a   Suzuki, Yoshihisa ^b   Ogata, Shin Ichi ^a   Ohtsuki, Chikara ^a   Tanihara, Masao ^a  

^a NARA INSTITUTE OF SCIENCE AND TECHNOLOGY   (Japan)

^b KYOTO UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

Author keywords

Alginate; BMP 2; Calcification; Osteoclasts; Synthetic peptide

Indexed keywords

BONE; CALCIFICATION (BIOCHEMISTRY); CARTILAGE; COLLAGEN; GELS; PROTEINS;

ALGINATE GELS; APOPTOSIS; ORGANOGENESIS; PEPTIDES;

BIOMEDICAL ENGINEERING;

ALGINIC ACID; ALKALINE PHOSPHATASE; BIOMATERIAL; BONE MORPHOGENETIC PROTEIN RECEPTOR; COLLAGEN GEL; MESSENGER RNA; OSTEOCALCIN; RECOMBINANT BONE MORPHOGENETIC PROTEIN 2; SYNTHETIC PEPTIDE;

ANIMAL TISSUE; APOPTOSIS; ARTICLE; BONE REGENERATION; CALCIFICATION; CARTILAGE; CELL ACTIVATION; CELL DIFFERENTIATION; CONJUGATION; COVALENT BOND; CROSS LINKING; ENZYME ACTIVITY; GASTROCNEMIUS MUSCLE; GEL; MALE; NONHUMAN; ORGANOGENESIS; OSSIFICATION; OSTEOBLAST; OSTEOCLAST; RAT;

EID: 3042727188     PISSN: 00219304     EISSN: None     Source Type: Journal    
DOI: 10.1002/jbm.a.30071     Document Type: Article

References (23)

1. Reddi AH. Role of morphogenetic proteins in skeletal tissue engineering and regeneration. Nat Biotech 1998;16:247-252.
2. Cunningham NS, Paralkar V, Reddi AH. Osteogenin and recombinant bone morphogenetic protein 2B are chemotactic for human monocytes and stimulate transforming growth factor beta 1 mRNA expression. Proc Natl Acad Sci USA 1992;89:11740-11744.
3. Aubin JE. Bone stem cells. J Cell Biochem 1998;Suppl 30-31:73-82.
4. Ducy P, Schinke T, Karsenty G. The osteoblast: A sophisticated fibroblast under central surveillance. Science 2000;289:1501-1504.
5. Groeneveld EHJ, Burger EH. Bone morphogenetic proteins in human bone regeneration. Eur J Endocrinol 2000;142:9-21.
6. Brekke JH, Toth JM. Principles of tissue engineering applied to programmable osteogenesis. J Biomed Mater Res (Appl Biomater) 1998;43:380-398.
7. Hollinger JO, Schmitt JM, Buck DC, Shannon R, Joh SP, Zegzula HD, Wozney J. Recombinant human bone morphogenetic protein-2 and collagen for bone regeneration. J Biomed Mater Res (Appl Biomater) 1998;43:356-364.
8. Butler D, Wadman M, Lehrman S, Schiermeier Q. Last chance to stop and think on risks of xenotransplants. Nature 1998;391:320-324.
9. Rosdy M, Clauss LC. Cytotoxicity testing of wound dressing using normal human keratinocytes in culture. J Biomed Mater Res 1990;24:363-377.
10. Suzuki Y, Nishimura Y, Tanihara M, Suzuki K, Shimizu Y, Yamawaki Y, Kakimaru Y. Evaluation of a novel alginate gel dressing: cytotoxicity to fibroblasts in vitro and foreign-body reaction in pig skin in vivo. J Biomed Mater Res 1998;39:317-322.
11. Sank A, Chi M, Shima T, Reich R, Martin GR. Increased calcium levels alter cellular and molecular events in wound healing. Surgery 1989;106:1141-1148.
12. Suzuki Y, Tanihara M, Nishimura Y, Suzuki K, Yamawaki Y, Kudo H, Kakimaru Y, Shimizu Y. In vivo evaluation of a novel alginate dressing. J Biomed Mater Res (Appl Biomater) 1999;48:522-527.
13. Suzuki Y, Tanihara M, Ohnishi K, Suzuki K, Endo K, Nishimura Y. Cat peripheral nerve regeneration across 50 mm gap repaired with a novel guide composed of freeze-dried alginate gel. Neurosci Lett 1999;259:75-78.
14. Suzuki K, Suzuki Y, Tanihara M, Ohnishi K, Hashimoto T, Endo K, Nishimura Y. Reconstruction of rat peripheral nerve gap without sutures using freeze-dried alginate gel. J Biomed Mater Res 2000;49:528-533.
15. Saito A, Suzuki Y, Ogata S, Ohtsuki C, Tanihara M. Activation of osteo-progenitor cells by a novel synthetic peptide derived from the bone morphogenetic protein-2 knuckle epitope. Biochim Biophys Acta 2003;1651:60-67.
16. Ito Y, Zheng J, Imanishi Y, Yonezawa K, Kasuga M. Protein-free cell culture on an artificial substrate with covalently immobilized insulin. Proc Natl Acad Sci USA 1996;93:3598-3601.
17. Marks SC Jr, Hermey DC. The structure and development of bone. In: Bilezikian JP, Raisz LG, Rodan GA, editors. Principles of bone biology. San Diego, CA: Academic Press; 1996. p 3-24.
18. Suda T, Udagawa N, Takahashi N. Cells of bone: Osteoclast generation. In Bilezikian JP, Raisz LG, Rodan GA, editors. Principles of bone biology. San Diego, CA: Academic Press; 1996. p 87-102.
19. Suda T, Takahashi N, Udagawa N, Jimi E, Gillespie MT, Martin TJ. Modulation of osteoclast differentiation and function by the new members of the tumor necrosis factor receptor and ligand families. Endocr Rev 1999;20:345-357.
20. Uludag H, Friess W, Williams D, Porter T, Timony G, D'Augusta D, Blake C, Palmer R, Biron B, Wozney J. rhBMP-collagen sponges as osteoinductive devices: Effects of in vitro sponge characteristics and protein pI on in vivo rhBMP pharmacokinetics. Ann NY Acad Sci 1999;18:369-378.
21. Uludag H, D'Augusta D, Palmer R, Timony G, Wozney J. Characterization of rhBMP-2 pharmacokinetics implanted with biomaterial carriers in the rat ectopic model. J Biomed Mater Res 1999;46:193-202.
22. Uludag H, D'Augusta D, Golden D, Li J, Timony G, Wozney JM. Implantation of recombinant human bone morphogenetic proteins with biomaterial carriers: A correlation between protein pharmacokinetics and osteoinduction in the rat ectopic model. J Biomed Mater Res 2000;50:227-238.
23. Tanahashi M, Matsuda T. Surface functional group dependence on apatite formation on self-assembled monolayers in a simulated body fluid. J Biomed Mater Res 1997;34:305-315.