-
2
-
-
0032489093
-
Orexins and orexin receptors: A family of hypothalamic neuropeptides and G protein-coupled receptors that regulate feeding behavior
-
DOI 10.1016/S0092-8674(00)80949-6
-
T. Sakurai Orexins and orexin receptors: a family of hypothalamic neuropeptides and G protein-coupled receptors that regulate feeding behavior Cell 92 1998 573 585 (Pubitemid 28101119)
-
(1998)
Cell
, vol.92
, Issue.4
, pp. 573-585
-
-
Sakurai, T.1
Amemiya, A.2
Ishii, M.3
Matsuzaki, I.4
Chemelli, R.M.5
Tanaka, H.6
Williams, S.C.7
Richardson, J.A.8
Kozlowski, G.P.9
Wilson, S.10
Arch, J.R.S.11
Buckingham, R.E.12
Haynes, A.C.13
Carr, S.A.14
Annan, R.S.15
McNulty, D.E.16
Liu, W.-S.17
Terrett, J.A.18
Elshourbagy, N.A.19
Bergsma, D.J.20
Yanagisawa, M.21
more..
-
3
-
-
3242765033
-
Regularly occurring periods of eye motility, and concomitant phenomena, during sleep
-
E. Aserinsky, and N. Kleitman Regularly occurring periods of eye motility, and concomitant phenomena, during sleep Science 118 1953 273 274
-
(1953)
Science
, vol.118
, pp. 273-274
-
-
Aserinsky, E.1
Kleitman, N.2
-
4
-
-
33847121297
-
The neural circuit of orexin (hypocretin): Maintaining sleep and wakefulness
-
DOI 10.1038/nrn2092, PII NRN2092
-
T. Sakurai The neural circuit of orexin (hypocretin): maintaining sleep and wakefulness Nat. Rev. Neurosci. 8 2007 171 181 (Pubitemid 46294664)
-
(2007)
Nature Reviews Neuroscience
, vol.8
, Issue.3
, pp. 171-181
-
-
Sakurai, T.1
-
5
-
-
30044447392
-
Role for hypocretin in mediating stress-induced reinstatement of cocaine-seeking behavior
-
DOI 10.1073/pnas.0507480102
-
B. Boutrel Role for hypocretin in mediating stress-induced reinstatement of cocaine-seeking behavior Proc. Natl. Acad. Sci. U.S.A. 102 2005 19168 19173 (Pubitemid 43049584)
-
(2005)
Proceedings of the National Academy of Sciences of the United States of America
, vol.102
, Issue.52
, pp. 19168-19173
-
-
Boutrel, B.1
Kenny, P.J.2
Specio, S.E.3
Martin-Fardon, R.4
Markou, A.5
Koob, G.F.6
De Lecea, L.7
-
6
-
-
0038521277
-
Hypothalamic orexin neurons regulate arousal according to energy balance in mice
-
DOI 10.1016/S0896-6273(03)00331-3
-
A. Yamanaka Hypothalamic orexin neurons regulate arousal according to energy balance in mice Neuron 38 2003 701 713 (Pubitemid 36694778)
-
(2003)
Neuron
, vol.38
, Issue.5
, pp. 701-713
-
-
Yamanaka, A.1
Beuckmann, C.T.2
Willie, J.T.3
Hara, J.4
Tsujino, N.5
Mieda, M.6
Tominaga, M.7
Yagami, K.-I.8
Sugiyama, F.9
Goto, K.10
Yanagisawa, M.11
Sakurai, T.12
-
8
-
-
9244251539
-
Orexin neurons function in an efferent pathway of a food-entrainable circadian oscillator in eliciting food-anticipatory activity and wakefulness
-
DOI 10.1523/JNEUROSCI.3171-04.2004
-
M. Mieda Orexin neurons function in an efferent pathway of a food-entrainable circadian oscillator in eliciting food-anticipatory activity and wakefulness J. Neurosci. 24 2004 10493 10501 (Pubitemid 39552634)
-
(2004)
Journal of Neuroscience
, vol.24
, Issue.46
, pp. 10493-10501
-
-
Mieda, M.1
Williams, S.C.2
Sinton, C.M.3
Richardson, J.A.4
Sakurai, T.5
Yanagisawa, M.6
-
9
-
-
20244374121
-
Input of orexin/hypocretin neurons revealed by a genetically encoded tracer in mice
-
DOI 10.1016/j.neuron.2005.03.010
-
T. Sakurai Input of orexin/hypocretin neurons revealed by a genetically encoded tracer in mice Neuron 46 2005 297 308 (Pubitemid 40545784)
-
(2005)
Neuron
, vol.46
, Issue.2
, pp. 297-308
-
-
Sakurai, T.1
Nagata, R.2
Yamanaka, A.3
Kawamura, H.4
Tsujino, N.5
Muraki, Y.6
Kageyama, H.7
Kunita, S.8
Takahashi, S.9
Goto, K.10
Koyama, Y.11
Shioda, S.12
Yanagisawa, M.13
-
11
-
-
25644432796
-
A role for lateral hypothalamic orexin neurons in reward seeking
-
DOI 10.1038/nature04071, PII N04071
-
G.C. Harris A role for lateral hypothalamic orexin neurons in reward seeking Nature 437 2005 556 559 (Pubitemid 41613553)
-
(2005)
Nature
, vol.437
, Issue.7058
, pp. 556-559
-
-
Harris, G.C.1
Wimmer, M.2
Aston-Jones, G.3
-
12
-
-
32344453801
-
Direct involvement of orexinergic systems in the activation of the mesolimbic dopamine pathway and related behaviors induced by morphine
-
DOI 10.1523/JNEUROSCI.2761-05.2006
-
M. Narita Direct involvement of orexinergic systems in the activation of the mesolimbic dopamine pathway and related behaviors induced by morphine J. Neurosci. 26 2006 398 405 (Pubitemid 43237102)
-
(2006)
Journal of Neuroscience
, vol.26
, Issue.2
, pp. 398-405
-
-
Narita, M.1
Nagumo, Y.2
Hashimoto, S.3
Narita, M.4
Khotib, J.5
Miyatake, M.6
Sakurai, T.7
Yanagisawa, M.8
Nakamachi, T.9
Shioda, S.10
Suzuki, T.11
-
13
-
-
0008390266
-
The hypocretins: Hypothalamus-specific peptides with neuroexcitatory activity
-
DOI 10.1073/pnas.95.1.322
-
L. de Lecea The hypocretins: hypothalamus-specific peptides with neuroexcitatory activity Proc. Natl. Acad. Sci. U.S.A. 95 1998 322 327 (Pubitemid 28103952)
-
(1998)
Proceedings of the National Academy of Sciences of the United States of America
, vol.95
, Issue.1
, pp. 322-327
-
-
De Lecea, L.1
Kilduff, T.S.2
Peyron, C.3
Gao, X.-B.4
Foye, P.E.5
Danielson, P.E.6
Fukuhara, C.7
Battenberg, E.L.F.8
Gautvik, V.T.9
Bartlett II, F.S.10
Frankel, W.N.11
Van Den Pol, A.N.12
Bloom, F.E.13
Gautvik, K.M.14
Sutcliffe, J.G.15
-
15
-
-
0042565939
-
Orexin receptor type-1 couples exclusively to pertussis toxin-insensitive G-proteins, while orexin receptor type-2 couples to both pertussis toxin-sensitive and -insensitive G-proteins
-
Y. Zhu Orexin receptor type-1 couples exclusively to pertussis toxin-insensitive G-proteins, while orexin receptor type-2 couples to both pertussis toxin-sensitive and -insensitive G-proteins J. Pharmacol. Sci. 92 2003 259 266 (Pubitemid 36992313)
-
(2003)
Journal of Pharmacological Sciences
, vol.92
, Issue.3
, pp. 259-266
-
-
Zhu, Y.1
Miwa, Y.2
Yamanaka, A.3
Yada, T.4
Shibahara, M.5
Abe, Y.6
Sakurai, T.7
Goto, K.8
-
16
-
-
0035908286
-
Differential expression of Orexin receptors 1 and 2 in the rat brain
-
DOI 10.1002/cne.1190
-
J.N. Marcus Differential expression of orexin receptors 1 and 2 in the rat brain J. Comp. Neurol. 435 2001 6 25 (Pubitemid 32448719)
-
(2001)
Journal of Comparative Neurology
, vol.435
, Issue.1
, pp. 6-25
-
-
Marcus, J.N.1
Aschkenasi, C.J.2
Lee, C.E.3
Chemelli, R.M.4
Saper, C.B.5
Yanagisawa, M.6
Elmquist, J.K.7
-
17
-
-
0032402181
-
Neurons containing hypocretin (orexin) project to multiple neuronal systems
-
C. Peyron Neurons containing hypocretin (orexin) project to multiple neuronal systems J. Neurosci. 18 1998 9996 10015 (Pubitemid 28543775)
-
(1998)
Journal of Neuroscience
, vol.18
, Issue.23
, pp. 9996-10015
-
-
Peyron, C.1
Tighe, D.K.2
Van Den Pol, A.N.3
De Lecea, L.4
Heller, H.C.5
Sutcliffe, J.G.6
Kilduff, T.S.7
-
18
-
-
0033535747
-
Distribution of orexin neurons in the adult rat brain
-
DOI 10.1016/S0006-8993(99)01336-0, PII S0006899399013360
-
T. Nambu Distribution of orexin neurons in the adult rat brain Brain Res. 827 1999 243 260 (Pubitemid 29222929)
-
(1999)
Brain Research
, vol.827
, Issue.1-2
, pp. 243-260
-
-
Nambu, T.1
Sakurai, T.2
Mizukami, K.3
Hosoya, Y.4
Yanagisawa, M.5
Goto, K.6
-
19
-
-
0033582175
-
Orexins, orexigenic hypothalamic peptides, interact with autonomic, neuroendocrine and neuroregulatory systems
-
DOI 10.1073/pnas.96.2.748
-
Y. Date Orexins, orexigenic hypothalamic peptides, interact with autonomic, neuroendocrine and neuroregulatory systems Proc. Natl. Acad. Sci. U.S.A. 96 1999 748 753 (Pubitemid 29061280)
-
(1999)
Proceedings of the National Academy of Sciences of the United States of America
, vol.96
, Issue.2
, pp. 748-753
-
-
Date, Y.1
Ueta, Y.2
Yamashita, H.3
Yamaguchi, H.4
Matsukura, S.5
Kangawa, K.6
Sakurai, T.7
Yanagisawa, M.8
Nakazato, M.9
-
20
-
-
0031912090
-
Genetic and familial aspects of narcolepsy
-
E. Mignot Genetic and familial aspects of narcolepsy Neurology 50 1998 S16 S22
-
(1998)
Neurology
, vol.50
-
-
Mignot, E.1
-
21
-
-
0033588184
-
Narcolepsy in orexin knockout mice: Molecular genetics of sleep regulation
-
DOI 10.1016/S0092-8674(00)81973-X
-
R.M. Chemelli Narcolepsy in orexin knockout mice: molecular genetics of sleep regulation Cell 98 1999 437 451 (Pubitemid 29402482)
-
(1999)
Cell
, vol.98
, Issue.4
, pp. 437-451
-
-
Chemelli, R.M.1
Willie, J.T.2
Sinton, C.M.3
Elmquist, J.K.4
Scammell, T.5
Lee, C.6
Richardson, J.A.7
Clay Williams, S.8
Xiong, Y.9
Kisanuki, Y.10
Fitch, T.E.11
Nakazato, M.12
Hammer, R.E.13
Saper, C.B.14
Yanagisawa, M.15
-
22
-
-
0033529520
-
The sleep disorder canine narcolepsy is caused by a mutation in the hypocretin (orexin) receptor 2 gene
-
DOI 10.1016/S0092-8674(00)81965-0
-
L. Lin The sleep disorder canine narcolepsy is caused by a mutation in the hypocretin (orexin) receptor 2 gene Cell 98 1999 365 376 (Pubitemid 29380571)
-
(1999)
Cell
, vol.98
, Issue.3
, pp. 365-376
-
-
Lin, L.1
Faraco, J.2
Li, R.3
Kadotani, H.4
Rogers, W.5
Lin, X.6
Qiu, X.7
De Jong, P.J.8
Nishino, S.9
Mignot, E.10
-
23
-
-
0034992322
-
Genetic ablation of orexin neurons in mice results in narcolepsy, hypophagia, and obesity
-
DOI 10.1016/S0896-6273(01)00293-8
-
J. Hara Genetic ablation of orexin neurons in mice results in narcolepsy, hypophagia, and obesity Neuron 30 2001 345 354 (Pubitemid 32530580)
-
(2001)
Neuron
, vol.30
, Issue.2
, pp. 345-354
-
-
Hara, J.1
Beuckmann, C.T.2
Nambu, T.3
Willie, J.T.4
Chemelli, R.M.5
Sinton, C.M.6
Sugiyama, F.7
Yagami, K.-I.8
Goto, K.9
Yanagisawa, M.10
Sakurai, T.11
-
24
-
-
0033826856
-
A mutation in a case of early onset narcolepsy and a generalized absence of hypocretin peptides in human narcoleptic brains
-
C. Peyron A mutation in a case of early onset narcolepsy and a generalized absence of hypocretin peptides in human narcoleptic brains Nat. Med. 9 2000 991 997
-
(2000)
Nat. Med.
, vol.9
, pp. 991-997
-
-
Peyron, C.1
-
25
-
-
0033710848
-
Reduced number of hypocretin neurons in human narcolepsy
-
T.C. Thannickal Reduced number of hypocretin neurons in human narcolepsy Neuron 27 2000 469 474
-
(2000)
Neuron
, vol.27
, pp. 469-474
-
-
Thannickal, T.C.1
-
26
-
-
0036791834
-
The role of cerebrospinal fluid hypocretin measurement in the diagnosis of narcolepsy and other hypersomnias
-
E. Mignot The role of cerebrospinal fluid hypocretin measurement in the diagnosis of narcolepsy and other hypersomnias Arch. Neurol. 59 2002 1553 1562
-
(2002)
Arch. Neurol.
, vol.59
, pp. 1553-1562
-
-
Mignot, E.1
-
28
-
-
0031861061
-
Genetic studies in the sleep disorder narcolepsy
-
H. Kadotani Genetic studies in the sleep disorder narcolepsy Genome Res. 8 1998 427 434 (Pubitemid 28256793)
-
(1998)
Genome Research
, vol.8
, Issue.5
, pp. 427-434
-
-
Kadotani, H.1
Faraco, J.2
Mignot, E.3
-
29
-
-
77949667777
-
Elevated Tribbles homolog 2-specific antibody levels in narcolepsy patients
-
V. Cvetkovic-Lopes Elevated Tribbles homolog 2-specific antibody levels in narcolepsy patients J. Clin. Invest. 120 2010 713 719
-
(2010)
J. Clin. Invest.
, vol.120
, pp. 713-719
-
-
Cvetkovic-Lopes, V.1
-
30
-
-
66649111903
-
Narcolepsy is strongly associated with the T-cell receptor alpha locus
-
J. Hallmayer Narcolepsy is strongly associated with the T-cell receptor alpha locus Nat. Genet. 41 2009 708 711
-
(2009)
Nat. Genet.
, vol.41
, pp. 708-711
-
-
Hallmayer, J.1
-
31
-
-
55049121064
-
Variant between CPT1B and CHKB associated with susceptibility to narcolepsy
-
T. Miyagawa Variant between CPT1B and CHKB associated with susceptibility to narcolepsy Nat. Genet. 40 2008 1324 1328
-
(2008)
Nat. Genet.
, vol.40
, pp. 1324-1328
-
-
Miyagawa, T.1
-
32
-
-
0038724250
-
Distinct narcolepsy syndromes in orexin receptor-2 and orexin null mice: Molecular genetic dissection of non-REM and REM sleep regulatory processes
-
DOI 10.1016/S0896-6273(03)00330-1
-
J.T. Willie Distinct narcolepsy syndromes in Orexin receptor-2 and Orexin null mice: molecular genetic dissection of non-REM and REM sleep regulatory processes Neuron 38 2003 715 730 (Pubitemid 36694779)
-
(2003)
Neuron
, vol.38
, Issue.5
, pp. 715-730
-
-
Willie, J.T.1
Chemelli, R.M.2
Sinton, C.M.3
Tokita, S.4
Williams, S.C.5
Kisanuki, Y.Y.6
Marcus, J.N.7
Lee, C.8
Elmquist, J.K.9
Kohlmeier, K.A.10
Leonard, C.S.11
Richardson, J.A.12
Hammer, R.E.13
Yanagisawa, M.14
-
33
-
-
33745512663
-
The neurobiology of hypocretins (orexins), narcolepsy and related therapeutic interventions
-
DOI 10.1016/j.tips.2006.05.006, PII S0165614706001301
-
J.M. Zeitzer The neurobiology of hypocretins (orexins), narcolepsy and related therapeutic interventions Trends Pharmacol. Sci. 27 2006 368 374 (Pubitemid 43963185)
-
(2006)
Trends in Pharmacological Sciences
, vol.27
, Issue.7
, pp. 368-374
-
-
Zeitzer, J.M.1
Nishino, S.2
Mignot, E.3
-
34
-
-
70350439281
-
Integrative physiology of orexins and orexin receptors
-
M. Mieda, and T. Sakurai Integrative physiology of orexins and orexin receptors CNS Neurol Disord Drug Targets 8 2009 281 295
-
(2009)
CNS Neurol Disord Drug Targets
, vol.8
, pp. 281-295
-
-
Mieda, M.1
Sakurai, T.2
-
35
-
-
79955777621
-
Differential roles of orexin receptor-1 and -2 in the regulation of non-REM and REM sleep
-
in press
-
Mieda, M. et al. Differential roles of orexin receptor-1 and -2 in the regulation of non-REM and REM sleep. J. Neurosci. in press
-
J. Neurosci.
-
-
Mieda, M.1
-
36
-
-
10644267749
-
Interaction between the corticotropin-releasing factor system and hypocretins (orexins): A novel circuit mediating stress response
-
DOI 10.1523/JNEUROSCI.3459-04.2004
-
R. Winsky-Sommerer Interaction between the corticotropin-releasing factor system and hypocretins (orexins): a novel circuit mediating stress response J. Neurosci. 24 2004 11439 11448 (Pubitemid 39658279)
-
(2004)
Journal of Neuroscience
, vol.24
, Issue.50
, pp. 11439-11448
-
-
Winsky-Sommerer, R.1
Yamanaka, A.2
Diano, S.3
Borok, E.4
Roberts, A.J.5
Sakurai, T.6
Kilduff, T.S.7
Horvath, T.L.8
De Lecea, L.9
-
37
-
-
0041629653
-
Attenuated defense response and low basal blood pressure in orexin knockout mice
-
Y. Kayaba Attenuated defense response and low basal blood pressure in orexin knockout mice Am. J. Physiol. Regul. Integr. Comp. Physiol. 285 2003 R581 R593
-
(2003)
Am. J. Physiol. Regul. Integr. Comp. Physiol.
, vol.285
-
-
Kayaba, Y.1
-
38
-
-
33744801936
-
Orexin neuron-mediated skeletal muscle vasodilation and shift of baroreflex during defense response in mice
-
W. Zhang Orexin neuron-mediated skeletal muscle vasodilation and shift of baroreflex during defense response in mice Am. J. Physiol. Regul. Integr. Comp. Physiol. 290 2006 R1654 R1663
-
(2006)
Am. J. Physiol. Regul. Integr. Comp. Physiol.
, vol.290
-
-
Zhang, W.1
-
39
-
-
61849174758
-
Orexin neurons in the hypothalamus mediate cardiorespiratory responses induced by disinhibition of the amygdala and bed nucleus of the stria terminalis
-
W. Zhang Orexin neurons in the hypothalamus mediate cardiorespiratory responses induced by disinhibition of the amygdala and bed nucleus of the stria terminalis Brain Res. 1262 2009 25 37
-
(2009)
Brain Res.
, vol.1262
, pp. 25-37
-
-
Zhang, W.1
-
40
-
-
77950522133
-
Reduced amygdala activity during aversive conditioning in human narcolepsy
-
A. Ponz Reduced amygdala activity during aversive conditioning in human narcolepsy Ann. Neurol. 67 2010 394 398
-
(2010)
Ann. Neurol.
, vol.67
, pp. 394-398
-
-
Ponz, A.1
-
41
-
-
27844592708
-
Orexinergic projections to the cat midbrain mediate alternation of emotional behavioural states from locomotion to cataplexy
-
DOI 10.1113/jphysiol.2005.085829
-
K. Takakusaki Orexinergic projections to the midbrain mediate alternation of emotional behavioral states from locomotion to cataplexy J. Physiol. 568 2005 1003 1020 (Pubitemid 41646038)
-
(2005)
Journal of Physiology
, vol.568
, Issue.3
, pp. 1003-1020
-
-
Takakusaki, K.1
Takahashi, K.2
Saitoh, K.3
Harada, H.4
Okumura, T.5
Kayama, Y.6
Koyama, Y.7
-
42
-
-
0023724417
-
Distribution of choline acetyltransferase immunoreactive somata in the feline brainstem: Implications for REM sleep generation
-
P.J. Shiromani Distribution of choline acetyltransferase immunoreactive somata in the feline brainstem: implications for REM sleep generation Sleep 11 1988 1 16
-
(1988)
Sleep
, vol.11
, pp. 1-16
-
-
Shiromani, P.J.1
-
43
-
-
3042554011
-
Mind versus metabolism in the control of food intake and energy balance
-
H.R. Berthoud Mind versus metabolism in the control of food intake and energy balance Physiol. Behav. 81 2004 781 793
-
(2004)
Physiol. Behav.
, vol.81
, pp. 781-793
-
-
Berthoud, H.R.1
-
44
-
-
0032080072
-
Neuropharmacological characterization of basal forebrain cholinergic stimulated cataplexy in narcoleptic canines
-
DOI 10.1006/exnr.1998.6787
-
M.S. Reid Neuropharmacological characterization of basal forebrain cholinergic stimulated cataplexy in narcoleptic canines Exp. Neurol. 151 1998 89 104 (Pubitemid 28223858)
-
(1998)
Experimental Neurology
, vol.151
, Issue.1
, pp. 89-104
-
-
Reid, M.S.1
Nishino, S.2
Tafti, M.3
Siegel, J.M.4
Dement, W.C.5
Mignot, E.6
-
45
-
-
0032526450
-
Innervation of histaminergic tuberomammillary neurons by GABAergic and galaninergic neurons in the ventrolateral preoptic nucleus of the rat
-
J.E. Sherin Innervation of histaminergic tuberomammillary neurons by GABAergic and galaninergic neurons in the ventrolateral preoptic nucleus of the rat J. Neurosci. 18 1998 4705 4721 (Pubitemid 28280179)
-
(1998)
Journal of Neuroscience
, vol.18
, Issue.12
, pp. 4705-4721
-
-
Sherin, J.E.1
Elmquist, J.K.2
Torrealba, F.3
Saper, C.B.4
-
47
-
-
33745755632
-
GABA(B) receptor-mediated modulation of hypocretin/orexin neurones in mouse hypothalamus
-
X. Xie GABA(B) receptor-mediated modulation of hypocretin/orexin neurones in mouse hypothalamus J. Physiol. 574 2006 399 414
-
(2006)
J. Physiol.
, vol.574
, pp. 399-414
-
-
Xie, X.1
-
48
-
-
63149122905
-
Selective loss of GABA(B) receptors in orexin-producing neurons results in disrupted sleep/wakefulness architecture
-
T. Matsuki Selective loss of GABA(B) receptors in orexin-producing neurons results in disrupted sleep/wakefulness architecture Proc. Natl. Acad. Sci. U.S.A. 106 2009 4459 4464
-
(2009)
Proc. Natl. Acad. Sci. U.S.A.
, vol.106
, pp. 4459-4464
-
-
Matsuki, T.1
-
50
-
-
11144301817
-
Reverse pharmacology of orexin: From an orphan GPCR to integrative physiology
-
DOI 10.1016/j.regpep.2004.08.006, PII S0167011504002885
-
T. Sakurai Reverse pharmacology of orexin: from an orphan GPCR to integrative physiology Regul. Pept. 126 2005 3 10 (Pubitemid 40037737)
-
(2005)
Regulatory Peptides
, vol.126
, Issue.1-2 SPEC. ISS.
, pp. 3-10
-
-
Sakurai, T.1
-
51
-
-
33745754494
-
Orexin neurons are directly and indirectly regulated by catecholamines in a complex manner
-
DOI 10.1152/jn.01361.2005
-
A. Yamanaka Orexin neurons are directly and indirectly regulated by catecholamines in a complex manner J. Neurophysiol. 96 2006 284 298 (Pubitemid 44015360)
-
(2006)
Journal of Neurophysiology
, vol.96
, Issue.1
, pp. 284-298
-
-
Yamanaka, A.1
Muraki, Y.2
Ichiki, K.3
Tsujino, N.4
Kilduff, T.S.5
Goto, K.6
Sakurai, T.7
-
52
-
-
0037137682
-
Hypocretin/orexin excites hypocretin neurons via a local glutamate neuron - A potential mechanism for orchestrating the hypothalamic arousal system
-
DOI 10.1016/S0896-6273(02)01132-7
-
Y. Li Hypocretin/Orexin excites hypocretin neurons via a local glutamate neuron-A potential mechanism for orchestrating the hypothalamic arousal system Neuron 36 2002 1169 1181 (Pubitemid 36044516)
-
(2002)
Neuron
, vol.36
, Issue.6
, pp. 1169-1181
-
-
Li, Y.1
Gao, X.-B.2
Sakurai, T.3
Van Den Pol, A.N.4
-
54
-
-
23744456008
-
Cholecystokinin activates orexin/hypocretin neurons through the cholecystokinin A receptor
-
DOI 10.1523/JNEUROSCI.1193-05.2005
-
N. Tsujino Cholecystokinin activates orexin/hypocretin neurons through the cholecystokinin A receptor J. Neurosci. 25 2005 7459 7469 (Pubitemid 41129819)
-
(2005)
Journal of Neuroscience
, vol.25
, Issue.32
, pp. 7459-7469
-
-
Tsujino, N.1
Yamanaka, A.2
Ichiki, K.3
Muraki, Y.4
Kilduff, T.S.5
Yagami, K.-I.6
Takahashi, S.7
Goto, K.8
Sakurai, T.9
-
55
-
-
77955177340
-
Activation of bombesin receptor subtype-3 influences activity of orexin neurons by both direct and indirect pathways
-
N. Furutani Activation of bombesin receptor subtype-3 influences activity of orexin neurons by both direct and indirect pathways J. Mol. Neurosci. 42 2010 106 111
-
(2010)
J. Mol. Neurosci.
, vol.42
, pp. 106-111
-
-
Furutani, N.1
-
56
-
-
77957193228
-
Orexin directly excites orexin neurons through orexin 2 receptor
-
A. Yamanaka Orexin directly excites orexin neurons through orexin 2 receptor J. Neurosci. 30 2010 12642 12652
-
(2010)
J. Neurosci.
, vol.30
, pp. 12642-12652
-
-
Yamanaka, A.1
-
57
-
-
14644396121
-
Physiological changes in glucose differentially modulate the excitability of hypothalamic melanin-concentrating hormone and orexin neurons in situ
-
DOI 10.1523/JNEUROSCI.4925-04.2005
-
D. Burdakov Physiological changes in glucose differentially modulate the excitability of hypothalamic melanin-concentrating hormone and orexin neurons in situ J. Neurosci. 25 2005 2429 2433 (Pubitemid 40322285)
-
(2005)
Journal of Neuroscience
, vol.25
, Issue.9
, pp. 2429-2433
-
-
Burdakov, D.1
Gerasimenko, O.2
Verkhratsky, A.3
-
58
-
-
33646914929
-
+ Channels Mediate Inhibition of Orexin Neurons by Glucose
-
DOI 10.1016/j.neuron.2006.04.032, PII S0896627306003692
-
D. Burdakov Tandem-pore K+ channels mediate inhibition of orexin neurons by glucose Neuron 50 2006 711 722 (Pubitemid 43792383)
-
(2006)
Neuron
, vol.50
, Issue.5
, pp. 711-722
-
-
Burdakov, D.1
Jensen, L.T.2
Alexopoulos, H.3
Williams, R.H.4
Fearon, I.M.5
O'Kelly, I.6
Gerasimenko, O.7
Fugger, L.8
Verkhratsky, A.9
-
59
-
-
0035157514
-
Hypoglycemia activates orexin neurons and selectively increases hypothalamic orexin-B levels: Responses inhibited by feeding and possibly mediated by the nucleus of the solitary tract
-
X.J. Cai Hypoglycemia activates orexin neurons and selectively increases hypothalamic orexin-B levels: responses inhibited by feeding and possibly mediated by the nucleus of the solitary tract Diabetes 50 2001 105 112 (Pubitemid 32047988)
-
(2001)
Diabetes
, vol.50
, Issue.1
, pp. 105-112
-
-
Cai, X.J.1
Evans, M.L.2
Lister, C.A.3
Leslie, R.A.4
Arch, J.R.S.5
Wilson, S.6
Williams, G.7
-
60
-
-
0035851851
-
The hypothalamus and the control of energy homeostasis: Different circuits, different purposes
-
DOI 10.1016/S0031-9384(01)00612-6, PII S0031938401006126
-
G. Williams The hypothalamus and the control of energy homeostasis: different circuits, different purposes Physiol. Behav. 74 2001 683 701 (Pubitemid 34076616)
-
(2001)
Physiology and Behavior
, vol.74
, Issue.4-5
, pp. 683-701
-
-
Williams, G.1
Bing, C.2
Cai, X.J.3
Harrold, J.A.4
King, P.J.5
Liu, X.H.6
-
61
-
-
0034704445
-
A selective orexin-1 receptor antagonist reduces food consumption in male and female rats
-
A.C. Haynes A selective orexin-1 receptor antagonist reduces food consumption in male and female rats Regul. Pept. 96 2000 45 51
-
(2000)
Regul. Pept.
, vol.96
, pp. 45-51
-
-
Haynes, A.C.1
-
62
-
-
13044249865
-
Orexin A activates locus coeruleus cell firing and increases arousal in the rat
-
DOI 10.1073/pnas.96.19.10911
-
J.J. Hagan Orexin A activates locus coeruleus cell firing and increases arousal in the rat Proc. Natl. Acad. Sci. U.S.A. 96 1999 10911 10916 (Pubitemid 29442243)
-
(1999)
Proceedings of the National Academy of Sciences of the United States of America
, vol.96
, Issue.19
, pp. 10911-10916
-
-
Hagan, J.J.1
Leslie, R.A.2
Patel, S.3
Evans, M.L.4
Wattam, T.A.5
Holmes, S.6
Benham, C.D.7
Taylor, S.G.8
Routledge, C.9
Hemmati, P.10
Munton, R.P.11
Ashmeade, T.E.12
Shah, A.S.13
Hatcher, J.P.14
Hatcher, P.D.15
Jones, D.N.C.16
Smith, M.I.17
Piper, D.C.18
Hunter, A.J.19
Porter, R.A.20
Upton, N.21
more..
-
63
-
-
69749116172
-
Sleep homeostasis modulates hypocretin-mediated sleep-to-wake transitions
-
M.E. Carter Sleep homeostasis modulates hypocretin-mediated sleep-to-wake transitions J Neurosci 29 2009 10939 10949
-
(2009)
J Neurosci
, vol.29
, pp. 10939-10949
-
-
Carter, M.E.1
-
64
-
-
36248996490
-
Neural substrates of awakening probed with optogenetic control of hypocretin neurons
-
DOI 10.1038/nature06310, PII NATURE06310
-
A.R. Adamantidis Neural substrates of awakening probed with optogenetic control of hypocretin neurons Nature 450 2007 420 424 (Pubitemid 350126754)
-
(2007)
Nature
, vol.450
, Issue.7168
, pp. 420-424
-
-
Adamantidis, A.R.1
Zhang, F.2
Aravanis, A.M.3
Deisseroth, K.4
De Lecea, L.5
-
65
-
-
0033552658
-
Hypocretin (orexin) activation and synaptic innervation of the locus coeruleus noradrenergic system
-
DOI 10.1002/(SICI)1096-9861(19991213)415: 2<145::AID-CNE1>3.0.CO;2- 2
-
T.L. Horvath Hypocretin (orexin) activation and synaptic innervation of the locus coeruleus noradrenergic system J. Comp. Neurol. 415 1999 145 159 (Pubitemid 29519873)
-
(1999)
Journal of Comparative Neurology
, vol.415
, Issue.2
, pp. 145-159
-
-
Horvath, T.L.1
Peyron, C.2
Diano, S.3
Ivanov, A.4
Aston-Jones, G.5
Kilduff, T.S.6
Van Den Pol, A.N.7
-
66
-
-
0034604826
-
Orexin-induced hyperlocomotion and stereotypy are mediated by the dopaminergic system
-
DOI 10.1016/S0006-8993(00)02555-5, PII S0006899300025555
-
T. Nakamura Orexin-induced hyperlocomotion and stereotypy are mediated by the dopaminergic system Brain Res. 873 2000 181 187 (Pubitemid 30468504)
-
(2000)
Brain Research
, vol.873
, Issue.1
, pp. 181-187
-
-
Nakamura, T.1
Uramura, K.2
Nambu, T.3
Yada, T.4
Goto, K.5
Yanagisawa, M.6
Sakurai, T.7
-
67
-
-
0036848635
-
Hypocretins (orexins) regulate serotonin neurons in the dorsal raphe nucleus by excitatory direct and inhibitory indirect actions
-
R.J. Liu Hypocretins (orexins) regulate serotonin neurons in the dorsal raphe nucleus by excitatory direct and inhibitory indirect actions J. Neurosci. 22 2002 9453 9464
-
(2002)
J. Neurosci.
, vol.22
, pp. 9453-9464
-
-
Liu, R.J.1
-
68
-
-
0037109767
-
Convergent excitation of dorsal raphe serotonin neurons by multiple arousal systems (orexin/hypocretin, histamine and noradrenaline)
-
R.E. Brown Convergent excitation of dorsal raphe serotonin neurons by multiple arousal systems (orexin/hypocretin, histamine and noradrenaline) J. Neurosci. 22 2002 8850 8859 (Pubitemid 35379054)
-
(2002)
Journal of Neuroscience
, vol.22
, Issue.20
, pp. 8850-8859
-
-
Brown, R.E.1
Sergeeva, O.A.2
Eriksson, K.S.3
Haas, H.L.4
-
69
-
-
18444375874
-
Orexins activate histaminergic neurons via the orexin 2 receptor
-
DOI 10.1006/bbrc.2001.6318
-
A. Yamanaka Orexins activate histaminergic neurons via the orexin 2 receptor Biochem. Biophys. Res. Commun. 290 2002 1237 1245 (Pubitemid 34694437)
-
(2002)
Biochemical and Biophysical Research Communications
, vol.290
, Issue.4
, pp. 1237-1245
-
-
Yamanaka, A.1
Tsujino, N.2
Funahashi, H.3
Honda, K.4
Guan, J.-L.5
Wang, Q.-P.6
Tominaga, M.7
Goto, K.8
Shioda, S.9
Sakurai, T.10
-
71
-
-
0035842557
-
Orexins/hypocretins excite basal forebrain cholinergic neurones
-
DOI 10.1016/S0306-4522(01)00512-7, PII S0306452201005127
-
E. Eggermann Orexins/hypocretins excite basal forebrain cholinergic neurones Neuroscience 108 2001 177 181 (Pubitemid 33152961)
-
(2001)
Neuroscience
, vol.108
, Issue.2
, pp. 177-181
-
-
Eggermann, E.1
Serafin, M.2
Bayer, L.3
Machard, D.4
Saint-Mleux, B.5
Jones, B.E.6
Muhlethaler, M.7
-
72
-
-
0033572664
-
Adenosinergic modulation of rat basal forebrain neurons during sleep and waking: Neuronal recording with microdialysis
-
M.N. Alam Adenosinergic modulation of rat basal forebrain neurons during sleep and waking: neuronal recording with microdialysis J Physiol. 521 1999 679 690 (Pubitemid 30042781)
-
(1999)
Journal of Physiology
, vol.521
, Issue.3
, pp. 679-690
-
-
Alam, M.N.1
Szymusiak, R.2
Gong, H.3
King, J.4
McGinty, D.5
-
73
-
-
0026516092
-
Pontine regulation of REM sleep components in cats: Integrity of the pedunculopontine tegmentum (PPT) is important for phasic events but unnecessary for atonia during REM sleep
-
M.N. Shouse, and J.M. Siegel Pontine regulation of REM sleep components in cats: integrity of the pedunculopontine tegmentum (PPT) is important for phasic events but unnecessary for atonia during REM sleep Brain Res. 571 1992 50 63
-
(1992)
Brain Res.
, vol.571
, pp. 50-63
-
-
Shouse, M.N.1
Siegel, J.M.2
-
74
-
-
0035906548
-
Effects on sleep and wakefulness of the injection of hypocretin-1 (orexin-A) into the laterodorsal tegmental nucleus of the cat
-
DOI 10.1016/S0006-8993(01)02317-4, PII S0006899301023174
-
M. Xi Effects on sleep and wakefulness of the injection of hypocretin-1 (orexin-A) into the laterodorsal tegmental nucleus of the cat Brain Res. 901 2001 259 264 (Pubitemid 32718830)
-
(2001)
Brain Research
, vol.901
, Issue.1-2
, pp. 259-264
-
-
Xi, M.-C.1
Morales, F.R.2
Chase, M.H.3
-
76
-
-
0036546690
-
Direct and Indirect Excitation of Laterodorsal Tegmental Neurons by Hypocretin/Orexin Peptides: Implications for Wakefulness and Narcolepsy
-
S. Burlet Direct and indirect excitation of laterodorsal tegmental neurons by hypocretin/orexin peptides: implication for wakefulness and narcolepsy J. Neurosci. 22 2002 2862 2872 (Pubitemid 37465835)
-
(2002)
Journal of Neuroscience
, vol.22
, Issue.7
, pp. 2862-2872
-
-
Burlet, S.1
Tyler, C.J.2
Leonard, C.S.3
-
77
-
-
0036674614
-
The neurobiology of sleep: Genetics, cellular physiology and subcortical networks
-
E.F. Pace-Schott, and J.A. Hobson The neurobiology of sleep: genetics, cellular physiology and subcortical networks Nat. Rev. Neurosci. 3 2002 591 605 (Pubitemid 135706668)
-
(2002)
Nature Reviews Neuroscience
, vol.3
, Issue.8
, pp. 591-605
-
-
Pace-Schott, E.F.1
Hobson, J.A.2
-
78
-
-
0035859825
-
Arousal effect of orexin A depends on activation of the histaminergic system
-
Z.L. Huang Arousal effect of orexin A depends on activation of the histaminergic system Proc. Natl. Acad. Sci. U.S.A. 98 2001 9965 9970
-
(2001)
Proc. Natl. Acad. Sci. U.S.A.
, vol.98
, pp. 9965-9970
-
-
Huang, Z.L.1
-
79
-
-
75749126518
-
Histamine-1 receptor is not required as a downstream effector of orexin-2 receptor in maintenance of basal sleep/wake states
-
M. Hondo Histamine-1 receptor is not required as a downstream effector of orexin-2 receptor in maintenance of basal sleep/wake states Acta Physiol. (Oxf.) 198 2010 287 294
-
(2010)
Acta Physiol. (Oxf.)
, vol.198
, pp. 287-294
-
-
Hondo, M.1
-
80
-
-
79951673017
-
Ectopic overexpression of orexin alters sleep/wakefulness states and muscle tone regulation during REM sleep in mice
-
J.T. Willie Ectopic overexpression of orexin alters sleep/wakefulness states and muscle tone regulation during REM sleep in mice J. Mol. Neurosci. 43 2011 155 161
-
(2011)
J. Mol. Neurosci.
, vol.43
, pp. 155-161
-
-
Willie, J.T.1
-
81
-
-
0035282983
-
Fos expression in orexin neurons varies with behavioral state
-
I.V. Estabrooke Fos expression in orexin neurons varies with behavioral state J. Neurosci. 21 2001 1656 1662 (Pubitemid 32182206)
-
(2001)
Journal of Neuroscience
, vol.21
, Issue.5
, pp. 1656-1662
-
-
Estabrooke, I.V.1
McCarthy, M.T.2
Ko, E.3
Chou, T.C.4
Chemelli, R.M.5
Yanagisawa, M.6
Saper, C.B.7
Scammell, T.E.8
-
82
-
-
0035783672
-
Fluctuation of extracellular hypocretin-1 (orexin A) levels in the rat in relation to the light-dark cycle and sleep-wake activities
-
DOI 10.1046/j.0953-816X.2001.01725.x
-
Y. Yoshida Fluctuation of extracellular hypocretin-1 (orexin A) levels in the rat in relation to the light-dark cycle and sleep-wake activities Eur. J. Neurosci. 14 2001 1075 1081 (Pubitemid 35463751)
-
(2001)
European Journal of Neuroscience
, vol.14
, Issue.7
, pp. 1075-1081
-
-
Yoshida, Y.1
Fujiki, N.2
Nakajima, T.3
Ripley, B.4
Matsumura, H.5
Yoneda, H.6
Mignot, E.7
Nishino, S.8
-
83
-
-
19544376694
-
Behavioral correlates of activity in identified hypocretin/orexin neurons
-
DOI 10.1016/j.neuron.2005.04.035, PII S0896627305003958
-
B.Y. Mileykovskiy Behavioral correlates of activity in identified hypocretin/orexin neurons Neuron 46 2005 787 798 (Pubitemid 40733133)
-
(2005)
Neuron
, vol.46
, Issue.5
, pp. 787-798
-
-
Mileykovskiy, B.Y.1
Kiyashchenko, L.I.2
Siegel, J.M.3
-
84
-
-
22244443005
-
Discharge of identified orexin/hypocretin neurons across the sleep-waking cycle
-
DOI 10.1523/JNEUROSCI.1887-05.2005
-
M.G. Lee Discharge of identified orexin/hypocretin neurons across the sleep-waking cycle J. Neurosci. 25 2005 6716 6720 (Pubitemid 40995304)
-
(2005)
Journal of Neuroscience
, vol.25
, Issue.28
, pp. 6716-6720
-
-
Lee, M.G.1
Hassani, O.K.2
Jones, B.E.3
-
85
-
-
43049176663
-
Neuronal activity of orexin and non-orexin waking-active neurons during wake-sleep states in the mouse
-
K. Takahashi Neuronal activity of orexin and non-orexin waking-active neurons during wake-sleep states in the mouse Neuroscience 153 2008 860 870
-
(2008)
Neuroscience
, vol.153
, pp. 860-870
-
-
Takahashi, K.1
-
86
-
-
0347418177
-
Disinhibition of ventrolateral preoptic area sleep-active neurons by adenosine: A new mechanism for sleep promotion
-
DOI 10.1016/j.neuroscience.2003.08.066
-
S. Morairty Disinhibition of ventrolateral preoptic area sleep-active neurons by adenosine: a new mechanism for sleep promotion Neuroscience 123 2004 451 457 (Pubitemid 38032921)
-
(2004)
Neuroscience
, vol.123
, Issue.2
, pp. 451-457
-
-
Morairty, S.1
Rainnie, D.2
McCarley, R.3
Greene, R.4
-
87
-
-
33646522163
-
Adenosine inhibits basal forebrain cholinergic and noncholinergic neurons in vitro
-
E. Arrigoni Adenosine inhibits basal forebrain cholinergic and noncholinergic neurons in vitro Neuroscience 140 2006 403 413
-
(2006)
Neuroscience
, vol.140
, pp. 403-413
-
-
Arrigoni, E.1
-
88
-
-
24944458193
-
Adenosine A2A, but not A1, receptors mediate the arousal effect of caffeine
-
Z.L. Huang Adenosine A2A, but not A1, receptors mediate the arousal effect of caffeine Nat. Neurosci. 8 2005 858 859
-
(2005)
Nat. Neurosci.
, vol.8
, pp. 858-859
-
-
Huang, Z.L.1
-
89
-
-
33745059329
-
Roles of orexins and orexin receptors in central regulation of feeding behavior and energy homeostasis
-
T. Sakurai Roles of orexins and orexin receptors in central regulation of feeding behavior and energy homeostasis CNS Neurol. Disord. Drug Targets 5 2006 313 325 (Pubitemid 43884171)
-
(2006)
CNS and Neurological Disorders - Drug Targets
, vol.5
, Issue.3
, pp. 313-325
-
-
Sakurai, T.1
-
90
-
-
0037086814
-
Anorectic, thermogenic and anti-obesity activity of a selective orexin-1 receptor antagonist in ob/ob mice
-
DOI 10.1016/S0167-0115(01)00358-5, PII S0167011501003585
-
A.C. Haynes Anorectic, thermogenic and anti-obesity activity of a selective orexin-1 receptor antagonist in ob/ob mice Regul. Pept. 104 2002 153 159 (Pubitemid 34119386)
-
(2002)
Regulatory Peptides
, vol.104
, Issue.1-3
, pp. 153-159
-
-
Haynes, A.C.1
Chapman, H.2
Taylor, C.3
Moore, G.B.T.4
Cawthorne, M.A.5
Tadayyon, M.6
Clapham, J.C.7
Arch, J.R.S.8
-
91
-
-
0032940785
-
The effect of the orexins on food intake: Comparison with neuropeptide Y, melanin-concentrating hormone and galanin
-
C.M. Edwards The effect of the orexins on food intake: comparison with neuropeptide Y, melanin-concentrating hormone and galanin J. Endocrinol. 160 1999 R7 R12
-
(1999)
J. Endocrinol.
, vol.160
-
-
Edwards, C.M.1
-
92
-
-
71449115890
-
Regulation of adaptive behaviour during fasting by hypothalamic Foxa2
-
J.P. Silva Regulation of adaptive behaviour during fasting by hypothalamic Foxa2 Nature 462 2009 646 650
-
(2009)
Nature
, vol.462
, pp. 646-650
-
-
Silva, J.P.1
-
93
-
-
18144370824
-
Difference in obesity phenotype between orexin-knockout mice and orexin neuron-deficient mice with same genetic background and environmental conditions
-
DOI 10.1016/j.neulet.2005.01.046
-
J. Hara Difference in obesity phenotype between orexin-knockout mice and orexin neuron-deficient mice with same genetic background and environmental conditions Neurosci. Lett. 380 2005 239 242 (Pubitemid 40616087)
-
(2005)
Neuroscience Letters
, vol.380
, Issue.3
, pp. 239-242
-
-
Hara, J.1
Yanagisawa, M.2
Sakurai, T.3
-
97
-
-
57849105425
-
Enhanced orexin receptor-2 signaling prevents diet-induced obesity and improves leptin sensitivity
-
H. Funato Enhanced orexin receptor-2 signaling prevents diet-induced obesity and improves leptin sensitivity Cell Metab. 9 2009 64 76
-
(2009)
Cell Metab.
, vol.9
, pp. 64-76
-
-
Funato, H.1
-
98
-
-
0034708393
-
Orexin-induced food intake involves neuropeptide Y pathway
-
DOI 10.1016/S0006-8993(00)02043-6, PII S0006899300020436
-
A. Yamanaka Orexin-induced food intake involves neuropeptide Y pathway Brain Res. 24 2000 404 409 (Pubitemid 30136120)
-
(2000)
Brain Research
, vol.859
, Issue.2
, pp. 404-409
-
-
Yamanaka, A.1
Kunii, K.2
Nambu, T.3
Tsujino, N.4
Sakai, A.5
Matsuzaki, I.6
Miwa, Y.7
Goto, K.8
Sakurai, T.9
-
99
-
-
12144288387
-
2+ signaling in a reciprocal manner to leptin: Orexigenic neuronal pathways in the mediobasal hypothalamus
-
DOI 10.1111/j.1460-9568.2004.03255.x
-
2+ signaling in a reciprocal manner to leptin: orexigenic neuronal pathways in the mediobasal hypothalamus Eur. J. Neurosci. 19 2004 1524 1534 (Pubitemid 38437915)
-
(2004)
European Journal of Neuroscience
, vol.19
, Issue.6
, pp. 1524-1534
-
-
Muroya, S.1
Funahashi, H.2
Yamanaka, A.3
Kohno, D.4
Uramura, K.5
Nambu, T.6
Shibahara, M.7
Kuramochi, M.8
Takigawa, M.9
Yanagisawa, M.10
Sakurai, T.11
Shioda, S.12
Yada, T.13
-
100
-
-
21544471830
-
Orexin A in the nucleus accumbens stimulates feeding and locomotor activity
-
DOI 10.1016/j.brainres.2005.05.045, PII S0006899305007882
-
A.J. Thorpe, and C.M. Kotz Orexin A in the nucleus accumbens stimulates feeding and locomotor activity Brain Res. 1050 2005 156 162 (Pubitemid 40922729)
-
(2005)
Brain Research
, vol.1050
, Issue.1-2
, pp. 156-162
-
-
Thorpe, A.J.1
Kotz, C.M.2
-
101
-
-
0842330416
-
A receptor-mediated inhibition of the nucleus accumbens shell, but not by exposure to a novel environment
-
DOI 10.1111/j.1460-9568.2004.03093.x
-
A receptor-mediated inhibition of the nucleus accumbens shell, but not by exposure to a novel environment Eur. J. Neurosci. 19 2004 376 386 (Pubitemid 38177876)
-
(2004)
European Journal of Neuroscience
, vol.19
, Issue.2
, pp. 376-386
-
-
Baldo, B.A.1
Gual-Bonilla, L.2
Sijapati, K.3
Daniel, R.A.4
Landry, C.F.5
Kelley, A.E.6
-
102
-
-
70449927248
-
Hypothalamic orexin stimulates feeding-associated glucose utilization in skeletal muscle via sympathetic nervous system
-
T. Shiuchi Hypothalamic orexin stimulates feeding-associated glucose utilization in skeletal muscle via sympathetic nervous system Cell Metab. 10 2009 466 480
-
(2009)
Cell Metab.
, vol.10
, pp. 466-480
-
-
Shiuchi, T.1
-
103
-
-
0033398188
-
Sympathetic and cardiovascular actions of orexins in conscious rats
-
T. Shirasaka Sympathetic and cardiovascular actions of orexins in conscious rats Am. J. Physiol. 277 1999 R1780 R1785
-
(1999)
Am. J. Physiol.
, vol.277
-
-
Shirasaka, T.1
-
104
-
-
32344446144
-
Orexin a in the VTA is critical for the induction of synaptic plasticity and behavioral sensitization to cocaine
-
DOI 10.1016/j.neuron.2006.01.016, PII S0896627306000456
-
S.L. Borgland Orexin A in the VTA is critical for the induction of synaptic plasticity and behavioral sensitization to cocaine Neuron 49 2006 589 601 (Pubitemid 43221893)
-
(2006)
Neuron
, vol.49
, Issue.4
, pp. 589-601
-
-
Borgland, S.L.1
Taha, S.A.2
Sarti, F.3
Fields, H.L.4
Bonci, A.5
-
105
-
-
0015944779
-
On the treatment of rapid eye movement narcolepsy
-
C. Guilleminault On the treatment of rapid eye movement narcolepsy Arch. Neurol. 30 1974 90 93
-
(1974)
Arch. Neurol.
, vol.30
, pp. 90-93
-
-
Guilleminault, C.1
-
106
-
-
33846979755
-
Promotion of sleep by targeting the orexin system in rats, dogs and humans
-
C. Brisbare-Roch Promotion of sleep by targeting the orexin system in rats, dogs and humans Nat. Med. 13 2007 150 155
-
(2007)
Nat. Med.
, vol.13
, pp. 150-155
-
-
Brisbare-Roch, C.1
-
107
-
-
77951497654
-
Orexin receptor antagonism, a new sleep-promoting paradigm: An ascending single-dose study with almorexant
-
P. Hoever Orexin receptor antagonism, a new sleep-promoting paradigm: an ascending single-dose study with almorexant Clin. Pharmacol. Ther. 87 2010 593 600
-
(2010)
Clin. Pharmacol. Ther.
, vol.87
, pp. 593-600
-
-
Hoever, P.1
-
108
-
-
77957368747
-
Intact learning and memory in rats following treatment with the dual orexin receptor antagonist almorexant
-
H. Dietrich, and F. Jenck Intact learning and memory in rats following treatment with the dual orexin receptor antagonist almorexant Psychopharmacology (Berl.) 212 2010 145 154
-
(2010)
Psychopharmacology (Berl.)
, vol.212
, pp. 145-154
-
-
Dietrich, H.1
Jenck, F.2
-
109
-
-
74549127520
-
Almorexant, a dual orexin receptor antagonist for the treatment of insomnia
-
D.N. Neubauer Almorexant, a dual orexin receptor antagonist for the treatment of insomnia Curr. Opin. Investig. Drugs 11 2010 101 110
-
(2010)
Curr. Opin. Investig. Drugs
, vol.11
, pp. 101-110
-
-
Neubauer, D.N.1
-
110
-
-
67649867893
-
Blockade of orexin-1 receptors attenuates orexin-2 receptor antagonism-induced sleep promotion in the rat
-
C. Dugovic Blockade of orexin-1 receptors attenuates orexin-2 receptor antagonism-induced sleep promotion in the rat J. Pharmacol. Exp. Ther. 330 2009 142 151
-
(2009)
J. Pharmacol. Exp. Ther.
, vol.330
, pp. 142-151
-
-
Dugovic, C.1
-
111
-
-
34547870546
-
Lateral hypothalamic orexin neurons are critically involved in learning to associate an environment with morphine reward
-
DOI 10.1016/j.bbr.2007.05.025, PII S0166432807002835
-
G.C. Harris Lateral hypothalamic orexin neurons are critically involved in learning to associate an environment with morphine reward Behav. Brain Res. 183 2007 43 51 (Pubitemid 47259526)
-
(2007)
Behavioural Brain Research
, vol.183
, Issue.1
, pp. 43-51
-
-
Harris, G.C.1
Wimmer, M.2
Randall-Thompson, J.F.3
Aston-Jones, G.4
-
112
-
-
79952992373
-
Orexin-1 receptor antagonist SB-334867 reduces the acquisition and expression of cocaine-conditioned reinforcement and the expression of amphetamine-conditioned reward
-
D.M. Hutcheson Orexin-1 receptor antagonist SB-334867 reduces the acquisition and expression of cocaine-conditioned reinforcement and the expression of amphetamine-conditioned reward Behav. Pharmacol. 22 2011 173 181
-
(2011)
Behav. Pharmacol.
, vol.22
, pp. 173-181
-
-
Hutcheson, D.M.1
-
113
-
-
73849143579
-
A key role for orexin in panic anxiety
-
P.L. Johnson A key role for orexin in panic anxiety Nat. Med. 16 2010 111 115
-
(2010)
Nat. Med.
, vol.16
, pp. 111-115
-
-
Johnson, P.L.1
-
115
-
-
77954731181
-
Discovery of the dual orexin receptor antagonist [(7R)-4-(5-chloro-1,3- benzoxazol-2-yl)-7-methyl-1,4-diazepan-1-yl][5-methy l-2-(2H-1,2,3-triazol-2-yl) phenyl]methanone (MK-4305) for the treatment of insomnia
-
C.D. Cox Discovery of the dual orexin receptor antagonist [(7R)-4-(5-chloro-1,3-benzoxazol-2-yl)-7-methyl-1,4-diazepan-1-yl][5-methy l-2-(2H-1,2,3-triazol-2-yl)phenyl]methanone (MK-4305) for the treatment of insomnia J. Med. Chem. 53 2010 5320 5332
-
(2010)
J. Med. Chem.
, vol.53
, pp. 5320-5332
-
-
Cox, C.D.1
-
116
-
-
1342322672
-
3H]-SB-674042, a novel nonpeptide antagonist, to the human orexin-1 receptor
-
DOI 10.1038/sj.bjp.0705610
-
C.J. Langmead Characterisation of the binding of [3H]-SB-674042, a novel nonpeptide antagonist, to the human orexin-1 receptor Br. J. Pharmacol. 141 2004 340 346 (Pubitemid 38250904)
-
(2004)
British Journal of Pharmacology
, vol.141
, Issue.2
, pp. 340-346
-
-
Langmead, C.J.1
Jerman, J.C.2
Brough, S.J.3
Scott, C.4
Porter, R.A.5
Herdon, H.J.6
-
117
-
-
0035939299
-
1,3-Biarylureas as selective non-peptide antagonists of the orexin-1 receptor
-
DOI 10.1016/S0960-894X(01)00343-2, PII S0960894X01003432
-
R.A. Porter 1,3-Biarylureas as selective non-peptide antagonists of the orexin-1 receptor Bioorg. Med. Chem. Lett. 11 2001 1907 1910 (Pubitemid 32675315)
-
(2001)
Bioorganic and Medicinal Chemistry Letters
, vol.11
, Issue.14
, pp. 1907-1910
-
-
Porter, R.A.1
Chan, W.N.2
Coulton, S.3
Johns, A.4
Hadley, M.S.5
Widdowson, K.6
Jerman, J.C.7
Brough, S.J.8
Coldwell, M.9
Smart, D.10
Jewitt, F.11
Jeffrey, P.12
Austin, N.13
-
118
-
-
3142668992
-
2R) antagonists
-
DOI 10.1016/j.bmcl.2004.06.032, PII S0960894X0400767X
-
L.C. McAtee Novel substituted 4-phenyl-[1,3]dioxanes: potent and selective orexin receptor 2 (OX(2)R) antagonists Bioorg. Med. Chem. Lett. 14 2004 4225 4229 (Pubitemid 38916941)
-
(2004)
Bioorganic and Medicinal Chemistry Letters
, vol.14
, Issue.16
, pp. 4225-4229
-
-
McAtee, L.C.1
Sutton, S.W.2
Rudolph, D.A.3
Li, X.4
Aluisio, L.E.5
Phuong, V.K.6
Dvorak, C.A.7
Lovenberg, T.W.8
Carruthers, N.I.9
Jones, T.K.10
|