메뉴 건너뛰기




Volumn 11, Issue 1, 2015, Pages 143-150

Hepcidin promotes osteogenic differentiation through the bone morphogenetic protein 2/small mothers against decapentaplegic and mitogen-activated protein kinase/P38 signaling pathways in mesenchymal stem cells

Author keywords

Activated protein kinase P38; Bone morphogenetic protein small mothers against decapentaplegic; Hepcidin; Mitogen; Osteogenic differentiation

Indexed keywords

ALKALINE PHOSPHATASE; BONE MORPHOGENETIC PROTEIN 2; DECAPENTAPLEGIC PROTEIN; HEPCIDIN; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE P38; SMAD1 PROTEIN; SMAD5 PROTEIN; SMAD8 PROTEIN; STRESS ACTIVATED PROTEIN KINASE; SMAD PROTEIN;

EID: 84916232307     PISSN: 17912997     EISSN: 17913004     Source Type: Journal    
DOI: 10.3892/mmr.2014.2769     Document Type: Article
Times cited : (25)

References (33)
  • 1
    • 55849107783 scopus 로고    scopus 로고
    • European guidance for the diagnosis and management of osteoporosis in postmenopausal women-what is the current message for clinical practice?
    • Kanis JA and Reginster JY: European guidance for the diagnosis and management of osteoporosis in postmenopausal women-what is the current message for clinical practice? Pol Arch Med Wewn 118: 538-540, 2008.
    • (2008) Pol Arch Med Wewn , vol.118 , pp. 538-540
    • Kanis, J.A.1    Reginster, J.Y.2
  • 2
    • 79953751008 scopus 로고    scopus 로고
    • Osteoporosis: Now and the future
    • Rachner TD, Khosla S and Hofbauer LC: Osteoporosis: now and the future. Lancet 377: 1276-1287, 2011.
    • (2011) Lancet , vol.377 , pp. 1276-1287
    • Rachner, T.D.1    Khosla, S.2    Hofbauer, L.C.3
  • 3
    • 84873573215 scopus 로고    scopus 로고
    • Metabolomic profles delineate signature metabolic shifts during estrogen defciency-induced bone loss in rat by GC-TOF/MS
    • Ma B, Liu J, Zhang Q, Ying H, A J, Sun J, Wu D, Wang Y, Li J and Liu Y: Metabolomic profles delineate signature metabolic shifts during estrogen defciency-induced bone loss in rat by GC-TOF/MS. PLoS One 8: e54965, 2013.
    • (2013) PLoS One , vol.8 , pp. e54965
    • Ma, B.1    Liu, J.2    Zhang, Q.3    Ying, H.J.A.4    Sun, J.5    Wu, D.6    Wang, Y.7    Li, J.8    Liu, Y.9
  • 4
    • 0029785626 scopus 로고    scopus 로고
    • Hormone replacement therapy: Clinical benefts and side-effects
    • de Lignieres B: Hormone replacement therapy: clinical benefts and side-effects. Maturitas 23: S31-S36, 1996.
    • (1996) Maturitas , vol.23 , pp. S31-S36
    • De Lignieres, B.1
  • 5
    • 14044266896 scopus 로고    scopus 로고
    • Breast cancer risk in relation to different types of hormone replacement therapy in the E3N-EPIC cohort
    • Fournier A, Berrino F, Riboli E, Avenel V and Clavel-Chapelon F: Breast cancer risk in relation to different types of hormone replacement therapy in the E3N-EPIC cohort. Int J Cancer 114: 448-454, 2005.
    • (2005) Int J Cancer , vol.114 , pp. 448-454
    • Fournier, A.1    Berrino, F.2    Riboli, E.3    Avenel, V.4    Clavel-Chapelon, F.5
  • 6
    • 34248574353 scopus 로고    scopus 로고
    • Ovarian cancer and hormone replacement therapy in the Million Women Study
    • Beral V, Million Women Study Collaborators, Bull D, Green J and Reeves G: Ovarian cancer and hormone replacement therapy in the Million Women Study. Lancet 369: 1703-1710, 2007.
    • (2007) Lancet , vol.369 , pp. 1703-1710
    • Beral, V.1    Bull, D.2    Green, J.3    Reeves, G.4
  • 8
    • 84867334961 scopus 로고    scopus 로고
    • Iron homeostasis in osteoporosis and its clinical implications
    • Li GF, Pan YZ, Sirois P, Li K and Xu YJ: Iron homeostasis in osteoporosis and its clinical implications. Osteoporos Int 23: 2403-2408, 2012.
    • (2012) Osteoporos Int , vol.23 , pp. 2403-2408
    • Li, G.F.1    Pan, Y.Z.2    Sirois, P.3    Li, K.4    Xu, Y.J.5
  • 9
    • 33750610853 scopus 로고    scopus 로고
    • Iron loading: A risk factor for osteoporosis
    • Weinberg ED: Iron loading: a risk factor for osteoporosis. Biometals 19: 633-635, 2006.
    • (2006) Biometals , vol.19 , pp. 633-635
    • Weinberg, E.D.1
  • 10
    • 62149108646 scopus 로고    scopus 로고
    • Association between iron overload and osteoporosis in patients with hereditary hemochromatosis
    • Valenti L, Varenna M, Fracanzani AL, Rossi V, Fargion S and Sinigaglia L: Association between iron overload and osteoporosis in patients with hereditary hemochromatosis. Osteoporos Int 20: 549-555, 2009.
    • (2009) Osteoporos Int , vol.20 , pp. 549-555
    • Valenti, L.1    Varenna, M.2    Fracanzani, A.L.3    Rossi, V.4    Fargion, S.5    Sinigaglia, L.6
  • 11
    • 58149512144 scopus 로고    scopus 로고
    • Role of iron in osteoporosis
    • Weinberg ED: Role of iron in osteoporosis. Pediatr Endocrinol Rev 6: 81-85, 2008.
    • (2008) Pediatr Endocrinol Rev , vol.6 , pp. 81-85
    • Weinberg, E.D.1
  • 12
    • 84893743248 scopus 로고    scopus 로고
    • Beta-thalassemia major and female fertility: The role of iron and iron-induced oxidative stress
    • Roussou P, Tsagarakis NJ, Kountouras D, Livadas S and Diamanti-Kandarakis E: Beta-thalassemia major and female fertility: the role of iron and iron-induced oxidative stress. Anemia 2013: 617204, 2013.
    • (2013) Anemia , vol.2013 , pp. 617204
    • Roussou, P.1    Tsagarakis, N.J.2    Kountouras, D.3    Livadas, S.4    Diamanti-Kandarakis, E.5
  • 13
    • 84899649150 scopus 로고    scopus 로고
    • Hepcidin defciency undermines bone load-bearing capacity through inducing iron overload
    • Sun L, Guo W, Yin C, Zhang S, Qu G, Hou Y, Rong H, Ji H and Liu S: Hepcidin defciency undermines bone load-bearing capacity through inducing iron overload. Gene 543: 161-165, 2014.
    • (2014) Gene , vol.543 , pp. 161-165
    • Sun, L.1    Guo, W.2    Yin, C.3    Zhang, S.4    Qu, G.5    Hou, Y.6    Rong, H.7    Ji, H.8    Liu, S.9
  • 14
    • 84862792124 scopus 로고    scopus 로고
    • Targeting the hepcidin-ferroportin axis to develop new treatment strategies for anemia of chronic disease and anemia of infammation
    • Sun CC, Vaja V, Babitt JL and Lin HY: Targeting the hepcidin-ferroportin axis to develop new treatment strategies for anemia of chronic disease and anemia of infammation. Am J Hematol 87: 392-400, 2012.
    • (2012) Am J Hematol , vol.87 , pp. 392-400
    • Sun, C.C.1    Vaja, V.2    Babitt, J.L.3    Lin, H.Y.4
  • 15
    • 84893972482 scopus 로고    scopus 로고
    • Hereditary hemochromatosis, iron, hepcidin, and coronary heart disease
    • Mascitelli L and Goldstein MR: Hereditary hemochromatosis, iron, hepcidin, and coronary heart disease. Med Hypotheses 82: 402-403, 2014
    • (2014) Med Hypotheses , vol.82 , pp. 402-403
    • Mascitelli, L.1    Goldstein, M.R.2
  • 16
    • 79951987291 scopus 로고    scopus 로고
    • The swinging pendulum of the anemia of cancer: Erythropoietin trumps hepcidin
    • Zucker S: The swinging pendulum of the anemia of cancer: erythropoietin trumps hepcidin. J Clin Oncol 29: e42, 2011.
    • (2011) J Clin Oncol , vol.29 , pp. e42
    • Zucker, S.1
  • 17
    • 84899434509 scopus 로고    scopus 로고
    • Hepcidin and HFE protein: Iron metabolism as a target for the anemia of chronic kidney disease
    • Canavesi E, Alferi C, Pelusi S and Valenti L Hepcidin and HFE protein: Iron metabolism as a target for the anemia of chronic kidney disease. World J Nephrol 1: 166-176, 2012.
    • (2012) World J Nephrol , vol.1 , pp. 166-176
    • Canavesi, E.1    Alferi, C.2    Pelusi, S.3    Valenti, L.4
  • 18
    • 80053574093 scopus 로고    scopus 로고
    • Hepcidin increases intracellular Ca2+ of osteoblast hFOB1.19 through L-type Ca2+ channels
    • Xu Y, Li G, Du B, Zhang P, Xiao L, Sirois P and Li K: Hepcidin increases intracellular Ca2+ of osteoblast hFOB1.19 through L-type Ca2+ channels. Regul Pept 172: 58-61, 2011.
    • (2011) Regul Pept , vol.172 , pp. 58-61
    • Xu, Y.1    Li, G.2    Du, B.3    Zhang, P.4    Xiao, L.5    Sirois, P.6    Li, K.7
  • 19
    • 84872142761 scopus 로고    scopus 로고
    • Interpretation of protein quantitation using the Bradford assay: Comparison with two calculation models
    • Ku HK, Lim HM, Oh KH, Yang HJ, Jeong JS and Kim SK: Interpretation of protein quantitation using the Bradford assay: comparison with two calculation models. Anal Biochem 434: 178-180, 2013.
    • (2013) Anal Biochem , vol.434 , pp. 178-180
    • Ku, H.K.1    Lim, H.M.2    Oh, K.H.3    Yang, H.J.4    Jeong, J.S.5    Kim, S.K.6
  • 20
    • 79551632249 scopus 로고    scopus 로고
    • Increased intracellular iron and mineralization of cultured hFOB 1.19 cells following hepcidin activation through ferroportin-1
    • Zhang P, Xu YJ, Zhao DY, Ma Y, Xiao L, Feng YS, Du BC, Qian ZM and Li K: Increased intracellular iron and mineralization of cultured hFOB 1.19 cells following hepcidin activation through ferroportin-1. Saudi Med J 31: 1303-1308, 2010.
    • (2010) Saudi Med J , vol.31 , pp. 1303-1308
    • Zhang, P.1    Xu, Y.J.2    Zhao, D.Y.3    Ma, Y.4    Xiao, L.5    Feng, Y.S.6    Du, B.C.7    Qian, Z.M.8    Li, K.9
  • 21
    • 77950603770 scopus 로고    scopus 로고
    • Rapamycin promotes the osteoblastic differentiation of human embryonic stem cells by blocking the mTOR pathway and stimulating the BMP/Smad pathway
    • Lee KW, Yook JY, Son MY, Kim MJ, Koo DB, Han YM and Cho YS: Rapamycin promotes the osteoblastic differentiation of human embryonic stem cells by blocking the mTOR pathway and stimulating the BMP/Smad pathway. Stem Cells Dev 19: 557-568, 2010.
    • (2010) Stem Cells Dev , vol.19 , pp. 557-568
    • Lee, K.W.1    Yook, J.Y.2    Son, M.Y.3    Kim, M.J.4    Koo, D.B.5    Han, Y.M.6    Cho, Y.S.7
  • 22
    • 84888592603 scopus 로고    scopus 로고
    • Nectandrin A Enhances the BMP-Induced Osteoblastic Differentiation and Mineralization by Activation of p38 MAPK-Smad Signaling Pathway
    • Kim do Y, Kim GW and Chung SH: Nectandrin A Enhances the BMP-Induced Osteoblastic Differentiation and Mineralization by Activation of p38 MAPK-Smad Signaling Pathway. Korean J Physiol Pharmacol 17: 447-453, 2013.
    • (2013) Korean J Physiol Pharmacol , vol.17 , pp. 447-453
    • Kim Do, Y.1    Kim, G.W.2    Chung, S.H.3
  • 23
    • 84863233123 scopus 로고    scopus 로고
    • Ginsenoside Rh2(S) induces the differentiation and mineralization of osteoblastic MC3T3-E1 cells through activation of PKD and p38 MAPK pathways
    • Kim do Y, Jung MS, Park YG, Yuan HD, Quan HY and Chung SH: Ginsenoside Rh2(S) induces the differentiation and mineralization of osteoblastic MC3T3-E1 cells through activation of PKD and p38 MAPK pathways. BMB Rep 44: 659-664, 2011.
    • (2011) BMB Rep , vol.44 , pp. 659-664
    • Kim Do, Y.1    Jung, M.S.2    Park, Y.G.3    Yuan, H.D.4    Quan, H.Y.5    Chung, S.H.6
  • 24
    • 36248932643 scopus 로고    scopus 로고
    • Concise review: Mesenchymal stem cells: Their phenotype, differentiation capacity, immunological features, and potential for homing
    • Chamberlain G, Fox J, Ashton B and Middleton J: Concise review: mesenchymal stem cells: their phenotype, differentiation capacity, immunological features, and potential for homing. Stem Cells 25: 2739-2749, 2007
    • (2007) Stem Cells , vol.25 , pp. 2739-2749
    • Chamberlain, G.1    Fox, J.2    Ashton, B.3    Middleton, J.4
  • 25
    • 0036727925 scopus 로고    scopus 로고
    • Hepcidin expression inversely correlates with the expression of duodenal iron transporters and iron absorption in rats
    • Frazer DM, Wilkins SJ, Becker EM, Vulpe CD, McKie AT, Trinder D and Anderson GJ: Hepcidin expression inversely correlates with the expression of duodenal iron transporters and iron absorption in rats. Gastroenterology 123: 835-844, 2002.
    • (2002) Gastroenterology , vol.123 , pp. 835-844
    • Frazer, D.M.1    Wilkins, S.J.2    Becker, E.M.3    Vulpe, C.D.4    McKie, A.T.5    Trinder, D.6    Anderson, G.J.7
  • 27
    • 84904239960 scopus 로고    scopus 로고
    • Genistein promotion of osteogenic differentiation through BMP/SMAD5/RUNX2 signaling
    • Dai J, Li Y, Zhou H, Chen J, Chen M and Xiao Z: Genistein promotion of osteogenic differentiation through BMP/SMAD5/RUNX2 signaling. Int J Biol Sci 9: 1089-1098, 2013.
    • (2013) Int J Biol Sci , vol.9 , pp. 1089-1098
    • Dai, J.1    Li, Y.2    Zhou, H.3    Chen, J.4    Chen, M.5    Xiao, Z.6
  • 28
    • 34848922689 scopus 로고    scopus 로고
    • Genistein stimulates osteoblastic differentiation via p38 MAPK-Cbfal pathway in bone marrow culture
    • Liao QC, Xiao ZS, Qin YF and Zhou HH: Genistein stimulates osteoblastic differentiation via p38 MAPK-Cbfal pathway in bone marrow culture. Acta Pharmacol Sin 28: 1597-1602, 2007
    • (2007) Acta Pharmacol Sin , vol.28 , pp. 1597-1602
    • Liao, Q.C.1    Xiao, Z.S.2    Qin, Y.F.3    Zhou, H.H.4
  • 30
    • 84890171521 scopus 로고    scopus 로고
    • Osteogenic differentiation of bone marrow MSCs by β-tricalcium phosphate stimulating macrophages via BMP2 signalling pathway
    • Chen Z, Wu C, Gu W, Klein T, Crawford R and Xiao Y Osteogenic differentiation of bone marrow MSCs by β-tricalcium phosphate stimulating macrophages via BMP2 signalling pathway. Biomaterials 35: 1507-1518, 2014
    • (2014) Biomaterials , vol.35 , pp. 1507-1518
    • Chen, Z.1    Wu, C.2    Gu, W.3    Klein, T.4    Crawford, R.5    Xiao, Y.6
  • 31
    • 34548825938 scopus 로고    scopus 로고
    • Iron transferrin regulates hepcidin synthesis in primary hepatocyte culture through hemojuvelin and BMP2/4
    • Lin L, Valore EV, Nemeth E, Goodnough JB, Gabayan V and Ganz T: Iron transferrin regulates hepcidin synthesis in primary hepatocyte culture through hemojuvelin and BMP2/4 Blood 110: 2182-2189, 2007
    • (2007) Blood , vol.110 , pp. 2182-2189
    • Lin, L.1    Valore, E.V.2    Nemeth, E.3    Goodnough, J.B.4    Gabayan, V.5    Ganz, T.6
  • 33
    • 84884342027 scopus 로고    scopus 로고
    • Function of TGF-beta and p38 MAKP signaling pathway in osteoblast differentiation from rat adipose-derived stem cells
    • Liu Y, Zheng WK, Gao WS, Shen Y and Ding WY Function of TGF-beta and p38 MAKP signaling pathway in osteoblast differentiation from rat adipose-derived stem cells. Eur Rev Med Pharmacol Sci 17: 1611-1619, 2013.
    • (2013) Eur Rev Med Pharmacol Sci , vol.17 , pp. 1611-1619
    • Liu, Y.1    Zheng, W.K.2    Gao, W.S.3    Shen, Y.4    Ding, W.Y.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.