Cyclization by a specific lactam increases the ability of human parathyroid hormone (hPTH)-(1-31)NH2 to stimulate bone growth in ovariectomized rats

Journal of Bone and Mineral Research

Volumn 12, Issue 8, 1997, Pages 1246-1252

  Whitfield, J F ^a   Morley, P ^a   Willick, G ^a   Langille, R ^a   Ross, V ^a   Maclean, S ^a   Barbier, J R ^a  

^a NATIONAL RESEARCH COUNCIL CANADA   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

LACTAM; OSTABOLIN; PARATHYROID HORMONE; UNCLASSIFIED DRUG;

ANIMAL MODEL; ARTICLE; BONE GROWTH; BONE METABOLISM; CYCLIZATION; ENZYME ACTIVATION; NONHUMAN; OSTEOPOROSIS; OVARIECTOMY; RAT;

ADENYLATE CYCLASE; ANALYSIS OF VARIANCE; ANIMALS; BONE DEVELOPMENT; BONE NEOPLASMS; DISEASE MODELS, ANIMAL; FEMALE; FEMUR; HUMANS; LACTAMS; MOLECULAR WEIGHT; OSTEOPOROSIS, POSTMENOPAUSAL; OSTEOSARCOMA; OVARIECTOMY; PARATHYROID HORMONE; PEPTIDE FRAGMENTS; RATS; SERINE; STRUCTURE-ACTIVITY RELATIONSHIP; TUMOR CELLS, CULTURED; VALINE;

EID: 0030740994     PISSN: 08840431     EISSN: None     Source Type: Journal    
DOI: 10.1359/jbmr.1997.12.8.1246     Document Type: Article

References (28)

1. Selye H 1932 On the stimulation of new bone formation with parathyroid extract and irradiated ergosterol. Endocrinology 16:547-558.
2. Tregear GW, van Rietschofen J, Greene E, Niall HD, Keutman HT, Parsons JA, O'Riordan JLH, Potts JTJ 1974 Solid phase synthesis of the biologically active N-terminal 1-34 peptide of human parathyroid hormone. Hoppe-Seyler's Z Physiol Chem 355:415-421.
3. Dempster DW, Cosman F, Parisien M, Shen V, Lindsay R 1993 Anabolic actions of parathyroid hormone on bone. Endocrinol Rev 14:690-709.
4. Gasser JA, Jerome CP 1992 Parathyroid hormone: A cure for osteoporosis? Triangle 31:111-121.
5. Hodsman AB, Fraher LJ, Watson PH 1997 Parathyroid hormone: The clinical experience and prospects. In: Whitfield JF, Morley P (eds.) Anabolic Treatments for Osteoporosis. CRC Press, Boca Raton, FL, U.S.A., (in press).
6. Mosekilde L, Danielson CC, Sogard CH, McOsker JE, Wronski TJ 1995 The anabolic effects of parathyroid hormone on cortical bone mass dimensions and strength -Assessed in sexually mature, ovariectomized rat model. Bone 16:223-230.
7. Reeve J 1996 PTH: A future role in the management of osteoporosis? J Bone Miner Res 11:440-445.
8. Whitfield JF, Morley P 1995 Small bone-building fragments of parathyroid hormone: New therapeutic agents for osteoporosis. Trends Pharmacol Sci 16:382-386.
9. Whitfield JF, Morley P, Langille R, Willick G 1997 Adenylyl cyclase-activating anabolic agents: Parathyroid hormone and prostaglandins E. In: Whitfield JF, Morley P (eds.) Anabolic Treatments for Osteoporosis. CRC Press, Boca Raton, FL, U.S.A., (in press).
10. Rixon RH, Whitfield JF, Gagnon L, Isaacs RJ, Maclean S, Chakravarthy B, Durkin JP, Neugebauer W, Ross V, Sung W, Willick G 1994 Parathyroid hormone fragments may stimulate bone growth in ovariectomized rats by activating adenylyl cyclase. J Bone Miner Res 9:1179-1189.
11. Strein K 1994 Are animal studies with bisphosphonates and PTH-fragments predictive for the clinical situation? In: Russell RG (Chairman) Bone Diseases and Osteoporosis. IBC Technical Services Limited, London, U.K., Article 12.
12. Jouishomme H, Whitfield JF, Gagnon L, Maclean S, Isaacs R, Chakravarthy B, Durkin J, Neugebauer W, Willick G, Rixon R 1994 Further definition of the protein kinase C activation domain of the parathyroid hormone. J Bone Miner Res 9:943-949.
13. Neugebauer W, Barbier J-R, Sung WL, Whitfield JF, Willick GE 1995 Solution structure and adenylyl cyclase stimulating activities of C-terminal truncated human parathyroid hormone analogues. Biochemistry 34:8835-8842.
14. 2 (Ostabolin). Calcif Tissue Int 58:81-87.
15. Whitfield JF 1995 Calcium in Cell Cycles and Cancer. CRC Press, Boca Raton, FL, U.S.A.
16. Ingleton PM, Danks JA 1996 Distribution and functions of parathyroid hormone-related protein in vertebrate cells. Int Rev Cytol 166:231-280.
17. Barbier J-R, Neugebauer W, Morley P, Ross V, Soska M, Whitfield JF, Willick G 1997 Bioactivities and secondary structures of constrained analogues of human parathyroid hormone: Cyclic lactams of the receptor binding region. J Medicinal Chem 40:1373-1380.
18. Caulfield MP, McKee RL, Goldman ME, Duong LT, Fisher JE, Gay CT, DeHaven PA, Levy JJ, Roubini E, Nutt RF, Chorev M, Rosenblatt M 1990 The bovine renal parathyroid hormone (PTH) receptor has equal affinity for 2 different amino acid sequences - the receptor-binding domains of PTH and PTH-related protein are located in the 14-34 region. Endocrinology 127:83-87.
19. Gardella TJ, Wilson AK, Keutman HT, Oberstein R, Potts JT, Kronenberg HM, Nussbaum SR 1993 Analysis of parathyroid hormone's principal receptor-binding region by sitedirected mutagenesis and analog design. Endocrinology 132:2024-2030.
20. Neugebauer W, Surewicz WK, Gordon HL, Somorjai RL, Sung W, Willick GE 1992 Structural elements of human parathyroid hormone and their possible relation to biological activities. Biochemistry 31:2056-2063.
21. Wray V, Federeau T, Gronwald W, Mayer H, Schomberg D, Tegge W, Wingender E 1994 The structure of human parathyroid hormone from a study of fragments in solution using H-1 NMR spectroscopy and its biological implications. Biochemistry 33:1684-1693.
22. Leslie FM, Goldstein V 1982 Degradation of dynorphin-(1-13) by membrane-bound rat brain enzymes. Neuropeptides 2:185-196.
23. Chorev M, Rosenblatt M 1996 Parathyroid hormone: Structure-function relations and analog design. In: Bilezikian JP, Raisz LG, Rodan GA (eds.) Principles of Bone Biology. Academic Press, San Diego, CA, U.S.A., pp. 305-323.
24. Bolin DR, Michalewsky J, Wasserman MA, O'Donnell M 1995 Design and development of a vasoactive intestinal peptide analog as a novel therapeutic for bronchial asthma. Biopolymers (Peptide Sci) 37:57-66.
25. Chorev M, Roubini E, McKee RL, Gibbons SW, Goldman ME, Caulfield MP, Rosenblatt M 1991 Cyclic parathyroid hormone related protein antagonists - Lysine-13 to aspartic acid 17 side chain to side chain lactamization. Biochemistry 30:5968-5974.
26. Szewczuk Z, Gibbs BF, Yue SY, Purisima EO, Konishi Y 1992 Conformationally restricted thrombin inhibitors resistant to proteolytic digestion. Biochemistry 31:9132-9140.
27. Thompson DD, Simmons HA, Pirie CM, Ze HZ 1995 FDA guidelines and animal models for osteoporosis. Bone 17:125S-133S.
28. Dempster Dw, Birchman R, Xu R, Lindsay R, Shen V 1995 Temporal changes in cancellous bone structure of rats immediately after ovaiectomy. Bone 16:157-161.