E3 ubiquitin ligase Smurf1 mediates core-binding factor α1/Runx2 degradation and plays a specific role in osteoblast differentiation

Journal of Biological Chemistry

Volumn 278, Issue 30, 2003, Pages 27939-27944

  Zhao, Ming ^a   Qiao, Mei ^a   Oyajobi, Babatunde O ^a   Mundy, Gregory R ^a   Chen, Di ^a  

^a UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER AT SAN ANTONIO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BONE; CELLS; DEGRADATION; PROTEINS;

OSTEOBLAST DIFFERENTIATION;

BIOCHEMISTRY;

BONE MORPHOGENETIC PROTEIN 2; CORE BINDING FACTOR; PROTEASOME; PROTEIN SMURF1; SMAD PROTEIN; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR RUNX2; UBIQUITIN PROTEIN LIGASE; UBIQUITIN PROTEIN LIGASE E3; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CELL DIFFERENTIATION; CONTROLLED STUDY; ENZYME INHIBITION; ENZYME MECHANISM; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; OSSIFICATION; OSTEOBLAST; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; PROTEIN TARGETING; REGULATORY MECHANISM;

ANIMALS; BONE AND BONES; CELL DIFFERENTIATION; CELL LINE; CELLS, CULTURED; CORE BINDING FACTOR ALPHA 1 SUBUNIT; CORE BINDING FACTORS; DNA, COMPLEMENTARY; DNA-BINDING PROTEINS; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME INHIBITORS; FORSKOLIN; IMMUNOBLOTTING; LIGASES; LUCIFERASES; MICE; NEOPLASM PROTEINS; OSTEOBLASTS; PEPTIDE HYDROLASES; PLASMIDS; PRECIPITIN TESTS; PROTEASOME ENDOPEPTIDASE COMPLEX; PROTEIN BINDING; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; SKULL; SMAD PROTEINS; SMAD1 PROTEIN; TRANS-ACTIVATORS; TRANSCRIPTION FACTORS; TRANSFECTION; UBIQUITIN-PROTEIN LIGASES;

ANIMALIA;

EID: 0041845297     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M304132200     Document Type: Article

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