Isolation and characterization of a novel peptide, osteoblast activating peptide (OBAP), associated with osteoblast differentiation and bone formation

Biochemical and Biophysical Research Communications

Volumn 400, Issue 1, 2010, Pages 157-163

  Fukushima, Nobuhiro ^a   Hiraoka, Koji ^a   Shirachi, Isao ^a   Kojima, Masayasu ^b   Nagata, Kensei ^a  

^a KURUME UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^b KURUME UNIVERSITY   (Japan)

Author keywords

Bone mineral density (BMD); Differentiation; Osteoblast; Peptide

Indexed keywords

ALKALINE PHOSPHATASE; CALCIUM; OSTEOBLAST ACTIVATING PEPTIDE; OSTEOCALCIN; PEPTIDE; UNCLASSIFIED DRUG; OSTEOBLAST ACTIVATING PEPTIDE, RAT;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BONE DENSITY; BONE METABOLISM; CALCIUM CELL LEVEL; CELL DIFFERENTIATION; CONTROLLED STUDY; DRUG EFFECT; ENZYME ACTIVITY; FETUS; GASTRECTOMY; MALE; NONHUMAN; NUCLEOTIDE SEQUENCE; OSSIFICATION; OSTEOBLAST; OSTEOPOROSIS; PEPTIDE ANALYSIS; PRIORITY JOURNAL; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; ANIMAL; BLOOD; BONE DEVELOPMENT; CELL PROLIFERATION; CHEMISTRY; CYTOLOGY; DRUG EFFECTS; ISOLATION AND PURIFICATION; METABOLISM; PROTEIN CONFORMATION; SPRAGUE DAWLEY RAT;

ALKALINE PHOSPHATASE; ANIMALS; BONE DENSITY; CALCIUM; CELL DIFFERENTIATION; CELL PROLIFERATION; OSTEOBLASTS; OSTEOGENESIS; PEPTIDES; PROTEIN CONFORMATION; RATS; RATS, SPRAGUE-DAWLEY;

RATTUS;

EID: 84755161376     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2010.08.036     Document Type: Article

References (22)

1. Stepnick L.S. The frequency of bone disease. Bone Health and Osteoporosis: A Report of the Surgeon General 2004, 68-87. Office of the US Surgeon General, Washington, DC. J.A. McGowan, L.G. Raisz, A.S. Noonan, A.L. Elderkin (Eds.).
2. Shoback D. Update in osteoporosis and metabolic bone disorders. J. Clin. Endocrinol. Metab. 2007, 92:747-753.
3. Bellows C.G., Aubin J.E., Heersche J.N. Physiological concentrations of glucocorticoids stimulate formation of bone nodules from isolated rat calvaria cells in vitro. Endocrinology 1987, 121:1985-1992.
4. Fukushima N., Hanada R., Teranishi H., Fukue Y., Tachibana T., Ishikawa H., Takeda S., Takeuchi Y., Fukumoto S., Kangawa K., Nagata K., Kojima M. Ghrelin directly regulates bone formation. J. Bone Miner. Res. 2005, 20:790-798.
5. Kojima M., Hosoda H., Date Y., Nakazato M., Matsuo H., Kangawa K. Ghrelin is a growth-hormone-releasing acylated peptide from stomach. Nature 1999, 402:656-660.
6. Editorial, Osteomalacia after gastrectomy, Lancet 1 (1986) 77-78.
7. Bussabarger R.A., Freeman S., Ivy A.C. The experimental production of severe homogeneous osteoporosis by gastrectomy in puppies. Am. J. Physiol. 1938, 121:137-148.
8. Tovey F.I., Hall M.L., Ell P.J., Hobsley M. Postgastrectomy osteoporosis. Br. J. Surg. 1991, 78:1335-1337.
9. Klinge B., Lehto-Axtelius D., Åkerman M., Håkanson R. Structure of calvaria after gastrectomy. An experimental study in the rat. Scand. J. Gastroenterol. 1995, 30:952-957.
10. Persson P., Gagnemo-Persson R., Chen D., Axelson J., Nylander A.G., Johnell O., Håkanson R. Gastrectomy causes bone loss in the rat: is lack of gastric acid responsible?. Scand. J. Gastroenterol. 1993, 28:301-306.
11. Nilas L., Christiansen C., Christiansen J. Regulation of vitamin D and calcium metabolism after gastrectomy. Gut 1985, 26:252-257.
12. Axelson J., Persson P., Gagnemo-Persson G., Håkansson R. Importance of the stomach in maintaining calcium homeostasis in the rat. Gut 1991, 32:1298-1302.
13. Davies M., Heys S.E., Selby P.L., Berry J.L., Mawer E.B. Increased catabolism of 25-hydroxyvitamin D in patients with partial gastrectomy and elevated 1,25-dihydroxyvitamin D levels. Implications for metabolic bone disease. J. Clin. Endocrinol. Metab. 1997, 82:209-212.
14. Maier G.W., Kreis M.E., Zittel T.T., Becker H.D. Calcium regulation and bone mass loss after total gastrectomy in pig. Ann. Surg. 1997, 225:181-192.
15. Lehto-Axtelius D., Stenström M., Johnell O. Osteopenia after gastrectomy, fundectomy, or antrectomy: an experimental study in the rat. Regul. Pept. 1998, 78:41-50.
16. 2+ second messenger response in osteoblastic cells. Regul. Pept. 2001, 97(2-3):153-161.
17. Larsson B., Norlén P., Lindström E., Zhao D., Håkanson R., Linde A. Effects of ECL cell extracts and granule/vesicle-enriched fractions from rat oxyntic mucosa on cAMP and IP(3) in rat osteoblast-like cells. Regul. Pept. 2002, 106(1-3):13-18.
18. Kitagawa M., Mukai H., Ono Y. Molecular cloning and characterization of a novel mitochondrial phosphoprotein, MIPP65, from rat liver. Exp. Cell Res. 1997, 235(1):71-78.
19. Mahon M.J., Donowitz M., Yun C.C., Segre G.V. Na(+)/H(+) exchanger regulatory factor 2 directs parathyroid hormone 1 receptor signalling. Nature 2002, 417(6891):858-861.
20. Persson P., Håkanson R., Axelson J., Sundler F. Gastrin releases a blood calcium-lowering peptide from the acid-producing part of the rat stomach. Proc. Natl Acad. Sci. USA 1989, 86:2834-2838.
21. 45Ca uptake into bone through release of gastric hormone. Regul. Pept. 1990, 28:107-118.
22. Håkanson R., Persson P., Axelson J. Elevated serum gastrin after food intake or acid blockade evokes hypocalcemia. Regul. Pept. 1990, 28:131-136.