메뉴 건너뛰기




Volumn , Issue , 2009, Pages 10-16

Signal Transduction Cascades Controlling Osteoblast Differentiation

Author keywords

catenin; Bone formation; Bone morphogenetic protein; Fibroblast growth factor: IGF; Hedgehog; Notch; Osteoblast; Osterix; nuclear factor for activated T cells; PTH; PTH related peptide; Runx2; Smad; TGF ; WNT

Indexed keywords


EID: 84889270042     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1002/9780470623992.ch2     Document Type: Chapter
Times cited : (41)

References (74)
  • 1
    • 0034975453 scopus 로고    scopus 로고
    • Mesenchymal stem cells: Building blocks for molecular medicine in the 21st century
    • Caplan AI, Bruder SP 2001 Mesenchymal stem cells: Building blocks for molecular medicine in the 21st century. Trends Mol Med 7:259-264.
    • (2001) Trends Mol Med , vol.7 , pp. 259-264
    • Caplan, A.I.1    Bruder, S.P.2
  • 3
    • 0027321842 scopus 로고
    • Molecular mechanisms mediating proliferation/differentiation interrelationships during progressive development of the osteoblast phenotype
    • Stein GS, Lian JB 1993 Molecular mechanisms mediating proliferation/differentiation interrelationships during progressive development of the osteoblast phenotype. Endocr Rev 14:424-442.
    • (1993) Endocr Rev , vol.14 , pp. 424-442
    • Stein, G.S.1    Lian, J.B.2
  • 5
    • 0033048965 scopus 로고    scopus 로고
    • Cleidocranial dysplasia: Clinical and molecular genetics
    • Mundlos S 1999 Cleidocranial dysplasia: Clinical and molecular genetics. J Med Genet 36:177-182.
    • (1999) J Med Genet , vol.36 , pp. 177-182
    • Mundlos, S.1
  • 7
    • 26844574658 scopus 로고    scopus 로고
    • Runx2: A master organizer of gene transcription in developing and maturing osteoblasts
    • Schroeder TM, Jensen ED, Westendorf JJ 2005 Runx2: A master organizer of gene transcription in developing and maturing osteoblasts. Birth Defects Res C Embryo Today 75:213-225.
    • (2005) Birth Defects Res C Embryo Today , vol.75 , pp. 213-225
    • Schroeder, T.M.1    Jensen, E.D.2    Westendorf, J.J.3
  • 9
    • 0035831510 scopus 로고    scopus 로고
    • Cbfal contributes to the osteoblast-specific expression of type I collagen genes
    • Kern B, Shen J, Starbuck M, Karsenty G 2001 Cbfal contributes to the osteoblast-specific expression of type I collagen genes. J Biol Chem 276:7101-7107.
    • (2001) J Biol Chem , vol.276 , pp. 7101-7107
    • Kern, B.1    Shen, J.2    Starbuck, M.3    Karsenty, G.4
  • 11
    • 0037059614 scopus 로고    scopus 로고
    • The novel zinc finger-containing transcription factor osterix is required for osteoblast differentiation and bone formation
    • Nakashima K, Zhou X, Kunkel G, Zhang Z, Deng JM, Behringer RR, de Crombrugghe B 2002 The novel zinc finger-containing transcription factor osterix is required for osteoblast differentiation and bone formation. Cell 108:17-29.
    • (2002) Cell , vol.108 , pp. 17-29
    • Nakashima, K.1    Zhou, X.2    Kunkel, G.3    Zhang, Z.4    Deng, J.M.5    Behringer, R.R.6    De Crombrugghe, B.7
  • 13
    • 34250019537 scopus 로고
    • Bone: Formation by autoinduction
    • Urist MR 1965 Bone: Formation by autoinduction. Science 150:893-899.
    • (1965) Science , vol.150 , pp. 893-899
    • Urist, M.R.1
  • 15
    • 33846004405 scopus 로고    scopus 로고
    • Bone morphogenetic proteins and their antagonists
    • Gazzerro E, Canalis E 2006 Bone morphogenetic proteins and their antagonists. Rev Endocr Metab Disord 7:51-65.
    • (2006) Rev Endocr Metab Disord , vol.7 , pp. 51-65
    • Gazzerro, E.1    Canalis, E.2
  • 17
    • 23044466047 scopus 로고    scopus 로고
    • Specificity and versatility in TGF-p5 signaling through Smads
    • Feng XH, Derynck R 2005 Specificity and versatility in TGF-p5 signaling through Smads. Annu Rev Cell Dev Biol 21:659-693.
    • (2005) Annu Rev Cell Dev Biol , vol.21 , pp. 659-693
    • Feng, X.H.1    Derynck, R.2
  • 20
    • 0034460993 scopus 로고    scopus 로고
    • Runx2 is a common target of transforming growth factor pi and bone morphogenetic protein 2, and cooperation between Runx2 and Smad5 induces osteoblast-specific gene expression in the pluripotent mesenchymal precursor cell line C2C12
    • Lee KS, Kim HJ, Li QL, Chi XZ, Ueta C, Komori T, Wozney JM, Kim EG, Choi JY, Ryoo HM, Bae SC 2000 Runx2 is a common target of transforming growth factor pi and bone morphogenetic protein 2, and cooperation between Runx2 and Smad5 induces osteoblast-specific gene expression in the pluripotent mesenchymal precursor cell line C2C12. Mol Cell Biol 20:8783-8792.
    • (2000) Mol Cell Biol , vol.20 , pp. 8783-8792
    • Lee, K.S.1    Kim, H.J.2    Li, Q.L.3    Chi, X.Z.4    Ueta, C.5    Komori, T.6    Wozney, J.M.7    Kim, E.G.8    Choi, J.Y.9    Ryoo, H.M.10    Bae, S.C.11
  • 22
    • 0033964720 scopus 로고    scopus 로고
    • Bone morphogenetic pro-tein-4 regulates its own expression in cultured osteoblasts
    • Pereira RC, Rydziel S, Canalis E 2000 Bone morphogenetic pro-tein-4 regulates its own expression in cultured osteoblasts. J Cell Physiol 182:239-246.
    • (2000) J Cell Physiol , vol.182 , pp. 239-246
    • Pereira, R.C.1    Rydziel, S.2    Canalis, E.3
  • 23
    • 0027496995 scopus 로고
    • Bone morphogenetic protein 2 transiently enhances expression of a gene, Id (inhibitor of differentiation), encoding a helix-loop-helix molecule in osteoblast-like cells
    • Ogata T, Wozney JM, Benezra R, Noda M 1993 Bone morphogenetic protein 2 transiently enhances expression of a gene, Id (inhibitor of differentiation), encoding a helix-loop-helix molecule in osteoblast-like cells. Proc Natl Acad Sci USA 90:9219-9222.
    • (1993) Proc Natl Acad Sci USA , vol.90 , pp. 9219-9222
    • Ogata, T.1    Wozney, J.M.2    Benezra, R.3    Noda, M.4
  • 24
    • 0037085441 scopus 로고    scopus 로고
    • Identification and functional characterization of distinct critically important bone morphogenetic protein-specific response elements in the Idl promoter
    • Korchynskyi O, ten Dijke P 2002 Identification and functional characterization of distinct critically important bone morphogenetic protein-specific response elements in the Idl promoter. J Biol Chem 277:4883-4891.
    • (2002) J Biol Chem , vol.277 , pp. 4883-4891
    • Korchynskyi, O.1    Ten Dijke, P.2
  • 25
    • 16544393624 scopus 로고    scopus 로고
    • Inhibitory helix-loop-helix transcription factors Idl/Id3 promote bone formation in vivo
    • Maeda Y, Tsuji K, Nifuji A, Nöda M 2004 Inhibitory helix-loop-helix transcription factors Idl/Id3 promote bone formation in vivo. J Cell Biochem 93:337-344.
    • (2004) J Cell Biochem , vol.93 , pp. 337-344
    • Maeda, Y.1    Tsuji, K.2    Nifuji, A.3    Nöda, M.4
  • 26
    • 23844506742 scopus 로고    scopus 로고
    • Osx transcriptional regulation is mediated by additional pathways to BMP2/Smad signaling
    • Celil AB, Hollinger JO, Campbell PG 2005 Osx transcriptional regulation is mediated by additional pathways to BMP2/Smad signaling. J Cell Biochem 95:518-528.
    • (2005) J Cell Biochem , vol.95 , pp. 518-528
    • Celil, A.B.1    Hollinger, J.O.2    Campbell, P.G.3
  • 27
    • 24744462930 scopus 로고    scopus 로고
    • BMP2 and insulin-like growth factor-I mediate Osterix (Osx) expression in human mesenchymal stem cells via the MAPK and protein kinase D signaling pathways
    • Celil AB, Campbell PG 2005 BMP2 and insulin-like growth factor-I mediate Osterix (Osx) expression in human mesenchymal stem cells via the MAPK and protein kinase D signaling pathways. J Biol Chem 280:31353-31359.
    • (2005) J Biol Chem , vol.280 , pp. 31353-31359
    • Celil, A.B.1    Campbell, P.G.2
  • 29
    • 0035991249 scopus 로고    scopus 로고
    • Smad3 promotes alkaline phosphatase activity and mineralization of osteoblastic MC3T3-E1 cells
    • Sowa H, Kaji H, Yamaguchi T, Sugimoto T, Chihara K 2002 Smad3 promotes alkaline phosphatase activity and mineralization of osteoblastic MC3T3-E1 cells. J Bone Miner Res 17:1190-1199.
    • (2002) J Bone Miner Res , vol.17 , pp. 1190-1199
    • Sowa, H.1    Kaji, H.2    Yamaguchi, T.3    Sugimoto, T.4    Chihara, K.5
  • 30
    • 0035341209 scopus 로고    scopus 로고
    • TGF-ß-induced repression of CBFA1 by Smad3 decreases cbfal and osteocalcin expression and inhibits osteoblast differentiation
    • Alliston T, Choy L, Ducy P, Karsenty G, Derynck R 2001 TGF-ß-induced repression of CBFA1 by Smad3 decreases cbfal and osteocalcin expression and inhibits osteoblast differentiation. EMBO J 20:2254-2272.
    • (2001) EMBO J , vol.20 , pp. 2254-2272
    • Alliston, T.1    Choy, L.2    Ducy, P.3    Karsenty, G.4    Derynck, R.5
  • 36
    • 33746808398 scopus 로고    scopus 로고
    • Wnt/ß-catenin signaling in development and disease
    • Clevers H 2006 Wnt/ß-catenin signaling in development and disease. Cell 127:469-180.
    • (2006) Cell , vol.127 , pp. 469-180
    • Clevers, H.1
  • 37
    • 17844372752 scopus 로고    scopus 로고
    • Wnt/ß-catenin signaling in mesenchymal progenitors controls osteoblast and chondrocyte differentiation during vertebrate skeletogenesis
    • Day TF, Guo X, Garrett-Beal L, Yang Y 2005 Wnt/ß-catenin signaling in mesenchymal progenitors controls osteoblast and chondrocyte differentiation during vertebrate skeletogenesis. Dev Cell 8:739-750.
    • (2005) Dev Cell , vol.8 , pp. 739-750
    • Day, T.F.1    Guo, X.2    Garrett-Beal, L.3    Yang, Y.4
  • 38
    • 17844363974 scopus 로고    scopus 로고
    • Canonical Wnt/ß-catenin signaling prevents osteoblasts from differentiating into chondrocytes
    • Hill TP, Spater D, Taketo MM, Birchmeier W, Hartmann C 2005 Canonical Wnt/ß-catenin signaling prevents osteoblasts from differentiating into chondrocytes. Dev Cell 8:727-738.
    • (2005) Dev Cell , vol.8 , pp. 727-738
    • Hill, T.P.1    Spater, D.2    Taketo, M.M.3    Birchmeier, W.4    Hartmann, C.5
  • 39
    • 13444302715 scopus 로고    scopus 로고
    • Sequential roles of Hedgehog and Wnt signaling in osteoblast development
    • Hu H, Hilton MJ, Tu X, Yu K, Ornitz DM, Long F 2005 Sequential roles of Hedgehog and Wnt signaling in osteoblast development. Development 132:49-60.
    • (2005) Development , vol.132 , pp. 49-60
    • Hu, H.1    Hilton, M.J.2    Tu, X.3    Yu, K.4    Ornitz, D.M.5    Long, F.6
  • 40
    • 0033567213 scopus 로고    scopus 로고
    • Indian hedgehog signaling regulates proliferation and differentiation of chondrocytes and is essential for bone formation
    • St Jacques B, Hammerschmidt M, McMahon AP 1999 Indian hedgehog signaling regulates proliferation and differentiation of chondrocytes and is essential for bone formation. Genes Dev 13:2072-2086.
    • (1999) Genes Dev , vol.13 , pp. 2072-2086
    • St Jacques, B.1    Hammerschmidt, M.2    McMahon, A.P.3
  • 41
    • 1842611651 scopus 로고    scopus 로고
    • Ihh signaling is directly required for the osteoblast lineage in the endochondral skeleton
    • Long F, Chung UI, Ohba S, McMahon J, Kronenberg HM, McMahon AP 2004 Ihh signaling is directly required for the osteoblast lineage in the endochondral skeleton. Development 131:1309-1318.
    • (2004) Development , vol.131 , pp. 1309-1318
    • Long, F.1    Chung, U.I.2    Ohba, S.3    McMahon, J.4    Kronenberg, H.M.5    McMahon, A.P.6
  • 43
    • 0027478216 scopus 로고
    • A mouse model of greig cephalopoly-syndactyly syndrome: The extra-toesJ mutation contains an intragenic deletion of the Gli3 gene
    • Hui CC, Joyner AL 1993 A mouse model of greig cephalopoly-syndactyly syndrome: The extra-toesJ mutation contains an intragenic deletion of the Gli3 gene. Nat Genet 3:241-246.
    • (1993) Nat Genet , vol.3 , pp. 241-246
    • Hui, C.C.1    Joyner, A.L.2
  • 44
    • 0037194765 scopus 로고    scopus 로고
    • Shh and Gli3 are dispensable for limb skeleton formation but regulate digit number and identity
    • Litingtung Y, Dahn RD, Li Y, Fallon JF, Chiang C 2002 Shh and Gli3 are dispensable for limb skeleton formation but regulate digit number and identity. Nature 418:979-983.
    • (2002) Nature , vol.418 , pp. 979-983
    • Litingtung, Y.1    Dahn, R.D.2    Li, Y.3    Fallon, J.F.4    Chiang, C.5
  • 48
    • 0036251217 scopus 로고    scopus 로고
    • Parathyroid hormone is essential for normal fetal bone formation
    • Miao D, He B, Karaplis AC, Goltzman D 2002 Parathyroid hormone is essential for normal fetal bone formation. J Clin Invest 109:1173-1182.
    • (2002) J Clin Invest , vol.109 , pp. 1173-1182
    • Miao, D.1    He, B.2    Karaplis, A.C.3    Goltzman, D.4
  • 49
    • 0029811142 scopus 로고    scopus 로고
    • Targeted overexpression of parathyroid hormone-related peptide in chondrocytes causes chondrodysplasia and delayed endochondral bone formation
    • Weir EC, Philbrick WM, Amling M, Neff LA, Baron R, Broadus AE 1996 Targeted overexpression of parathyroid hormone-related peptide in chondrocytes causes chondrodysplasia and delayed endochondral bone formation. Proc Natl Acad Sci USA 93:10240-10245.
    • (1996) Proc Natl Acad Sci USA , vol.93 , pp. 10240-10245
    • Weir, E.C.1    Philbrick, W.M.2    Amling, M.3    Neff, L.A.4    Baron, R.5    Broadus, A.E.6
  • 51
    • 0031769483 scopus 로고    scopus 로고
    • A homozygous inactivating mutation in the parathyroid hormone/parathyroid hormone-related peptide receptor causing Blomstrand chondrodysplasia
    • Zhang P, Jobert AS, Couvineau A, Silve C 1998 A homozygous inactivating mutation in the parathyroid hormone/parathyroid hormone-related peptide receptor causing Blomstrand chondrodysplasia. J Clin Endocrinol Metab 83:3365-3368.
    • (1998) J Clin Endocrinol Metab , vol.83 , pp. 3365-3368
    • Zhang, P.1    Jobert, A.S.2    Couvineau, A.3    Silve, C.4
  • 53
    • 28144465050 scopus 로고    scopus 로고
    • Multiple mechanisms are involved in inhibition of osteoblast differentiation by PTHrP and PTH in KS483 Cells
    • van der Horst G, Farih-Sips H, Lowik CW, Karperien M 2005 Multiple mechanisms are involved in inhibition of osteoblast differentiation by PTHrP and PTH in KS483 Cells. J Bone Miner Res 20:2233-2244.
    • (2005) J Bone Miner Res , vol.20 , pp. 2233-2244
    • Van Der Horst, G.1    Farih-Sips, H.2    Lowik, C.W.3    Karperien, M.4
  • 54
    • 0025765080 scopus 로고
    • Growth factors and cytokines in bone cell metabolism
    • Canalis E, McCarthy TL, Centrella M 1991 Growth factors and cytokines in bone cell metabolism. Annu Rev Med 42:17-24.
    • (1991) Annu Rev Med , vol.42 , pp. 17-24
    • Canalis, E.1    McCarthy, T.L.2    Centrella, M.3
  • 57
    • 3142707223 scopus 로고    scopus 로고
    • Runx2 induces osteoblast and chondrocyte differentiation and enhances their migration by coupling with PI3K-Akt signaling
    • Fujita T, Azuma Y, Fukuyama R, Hattori Y, Yoshida C, Koida M, Ogita K, Komori T 2004 Runx2 induces osteoblast and chondrocyte differentiation and enhances their migration by coupling with PI3K-Akt signaling. J Cell Biol 166:85-95.
    • (2004) J Cell Biol , vol.166 , pp. 85-95
    • Fujita, T.1    Azuma, Y.2    Fukuyama, R.3    Hattori, Y.4    Yoshida, C.5    Koida, M.6    Ogita, K.7    Komori, T.8
  • 58
    • 18144391965 scopus 로고    scopus 로고
    • FGF signaling in the developing endochondral skeleton
    • Ornitz DM 2005 FGF signaling in the developing endochondral skeleton. Cytokine Growth Factor Rev 16:205-213.
    • (2005) Cytokine Growth Factor Rev , vol.16 , pp. 205-213
    • Ornitz, D.M.1
  • 60
    • 0038782306 scopus 로고    scopus 로고
    • Conditional inactivation of FGF receptor 2 reveals an essential role for FGF signaling in the regulation of osteoblast function and bone growth
    • Yu K, Xu J, Liu Z, Sosic D, Shao J, Olson EN, Towler DA, Ornitz DM 2003 Conditional inactivation of FGF receptor 2 reveals an essential role for FGF signaling in the regulation of osteoblast function and bone growth. Development 130:3063-3074.
    • (2003) Development , vol.130 , pp. 3063-3074
    • Yu, K.1    Xu, J.2    Liu, Z.3    Sosic, D.4    Shao, J.5    Olson, E.N.6    Towler, D.A.7    Ornitz, D.M.8
  • 61
    • 0037441529 scopus 로고    scopus 로고
    • Regulation of the osteoblast-specific transcription factor, Runx2: Responsiveness to multiple signal transduction pathways
    • Franceschi RT, Xiao G 2003 Regulation of the osteoblast-specific transcription factor, Runx2: Responsiveness to multiple signal transduction pathways. J Cell Biochem 88:446-454.
    • (2003) J Cell Biochem , vol.88 , pp. 446-454
    • Franceschi, R.T.1    Xiao, G.2
  • 62
    • 0037414760 scopus 로고    scopus 로고
    • The protein kinase C pathway plays a central role in the fibroblast growth factor-stimulated expression and transactivation activity of Runx2
    • Kim HJ, Kim JH, Bae SC, Choi JY, Kim HJ, Ryoo HM 2003 The protein kinase C pathway plays a central role in the fibroblast growth factor-stimulated expression and transactivation activity of Runx2. J Biol Chem 278:319-326.
    • (2003) J Biol Chem , vol.278 , pp. 319-326
    • Kim, H.J.1    Kim, J.H.2    Bae, S.C.3    Choi, J.Y.4    Kim, H.J.5    Ryoo, H.M.6
  • 64
    • 4444246433 scopus 로고    scopus 로고
    • Coordinated activation of notch, Wnt, and transforming growth factor-p signaling pathways in bone morphogenic protein 2-induced osteogenesis
    • Notch target gene Heyl inhibits mineralization and Runx2 transcriptional activity
    • Zamurovic N, Cappellen D, Rohner D, Susa M 2004 Coordinated activation of notch, Wnt, and transforming growth factor-p signaling pathways in bone morphogenic protein 2-induced osteogenesis. Notch target gene Heyl inhibits mineralization and Runx2 transcriptional activity. J Biol Chem 279:37704-37715.
    • (2004) J Biol Chem , vol.279 , pp. 37704-37715
    • Zamurovic, N.1    Cappellen, D.2    Rohner, D.3    Susa, M.4
  • 65
    • 33646550902 scopus 로고    scopus 로고
    • Notch 1 overexpression inhibits osteoblastogenesis by suppressing Wnt/p-catenin but not bone morphogenetic protein signaling
    • Deregowski V, Gazzerro E, Priest L, Rydziel S, Canalis E 2006 Notch 1 overexpression inhibits osteoblastogenesis by suppressing Wnt/p-catenin but not bone morphogenetic protein signaling. J Biol Chem 281:6203-6210.
    • (2006) J Biol Chem , vol.281 , pp. 6203-6210
    • Deregowski, V.1    Gazzerro, E.2    Priest, L.3    Rydziel, S.4    Canalis, E.5
  • 68
    • 10744228365 scopus 로고    scopus 로고
    • Receptor tyrosine kinases inhibit bone morphogenetic protein-Smad responsive promoter activity and differentiation of murine MC3T3-El osteoblast-like cells
    • Nakayama K, Tamura Y, Suzawa M, Harada S, Fukumoto S, Kato M, Miyazono K, Rodan GA, Takeuchi Y, Fujita T 2003 Receptor tyrosine kinases inhibit bone morphogenetic protein-Smad responsive promoter activity and differentiation of murine MC3T3-El osteoblast-like cells. J Bone Miner Res 18:827-835.
    • (2003) J Bone Miner Res , vol.18 , pp. 827-835
    • Nakayama, K.1    Tamura, Y.2    Suzawa, M.3    Harada, S.4    Fukumoto, S.5    Kato, M.6    Miyazono, K.7    Rodan, G.A.8    Takeuchi, Y.9    Fujita, T.10
  • 69
    • 13444262316 scopus 로고    scopus 로고
    • Smadl, ß-catenin and Tcf4 associate in a molecular complex with the Myc promoter in dysplastic renal tissue and cooperate to control Myc transcription
    • Hu MC, Rosenblum ND 2005 Smadl, ß-catenin and Tcf4 associate in a molecular complex with the Myc promoter in dysplastic renal tissue and cooperate to control Myc transcription. Development 132:215-225.
    • (2005) Development , vol.132 , pp. 215-225
    • Hu, M.C.1    Rosenblum, N.D.2
  • 70
    • 0034682515 scopus 로고    scopus 로고
    • Association of Smads with lymphoid enhancer binding factor 1/T cell-specific factor mediates cooperative signaling by the transforming growth factor-fi and wnt pathways
    • Labbe E, Letamendia A, Attisano L 2000 Association of Smads with lymphoid enhancer binding factor 1/T cell-specific factor mediates cooperative signaling by the transforming growth factor-fi and wnt pathways. Proc Natl Acad Sci USA 97:8358-8363.
    • (2000) Proc Natl Acad Sci USA , vol.97 , pp. 8358-8363
    • Labbe, E.1    Letamendia, A.2    Attisano, L.3
  • 72
    • 33746987081 scopus 로고    scopus 로고
    • The zinc finger transcription factor Gli2 mediates bone morphogenetic protein 2 expression in osteoblasts in response to hedgehog signaling
    • Zhao M, Qiao M, Harris SE, Chen D, Oyajobi BO, Mundy GR 2006 The zinc finger transcription factor Gli2 mediates bone morphogenetic protein 2 expression in osteoblasts in response to hedgehog signaling. Mol Cell Biol 26:6197-6208.
    • (2006) Mol Cell Biol , vol.26 , pp. 6197-6208
    • Zhao, M.1    Qiao, M.2    Harris, S.E.3    Chen, D.4    Oyajobi, B.O.5    Mundy, G.R.6
  • 73
    • 34447509873 scopus 로고    scopus 로고
    • Endogenous TNFalpha lowers maximum peak bone mass and inhibits osteoblastic Smad activation through NF-kappaB
    • Li Y, Li A, Strait K, Zhang H, Nanes MS, Weitzmann MN 2007 Endogenous TNFalpha lowers maximum peak bone mass and inhibits osteoblastic Smad activation through NF-kappaB. J Bone Miner Res 22:646-655.
    • (2007) J Bone Miner Res , vol.22 , pp. 646-655
    • Li, Y.1    Li, A.2    Strait, K.3    Zhang, H.4    Nanes, M.S.5    Weitzmann, M.N.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.