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Volumn 113, Issue 18, 2009, Pages 4319-4330

Bortezomib induces osteoblast differentiation via Wnt-independent activation of β-catenin/TCF signaling

Author keywords

[No Author keywords available]

Indexed keywords

BETA CATENIN; BORTEZOMIB; CALCIUM; GLYCOGEN SYNTHASE KINASE 3BETA; MESSENGER RNA; PROTEASOME INHIBITOR; T CELL FACTOR PROTEIN; WNT PROTEIN; BORONIC ACID DERIVATIVE; CADHERIN; LUCIFERASE; PROTEINASE INHIBITOR; PYRAZINE DERIVATIVE;

EID: 66149127277     PISSN: 00064971     EISSN: 15280020     Source Type: None    
DOI: 10.1182/blood-2008-08-174300     Document Type: Article
Times cited : (132)

References (59)
  • 1
    • 34548029349 scopus 로고    scopus 로고
    • Myeloma bone disease and proteasome inhibition therapies
    • DOI 10.1182/blood-2007-03-067710
    • Terpos E, Sezer O, Croucher P, Dimopoulos MA. Myeloma bone disease and proteasome inhibition therapies. Blood. 2007;110:1098-1104. (Pubitemid 47281403)
    • (2007) Blood , vol.110 , Issue.4 , pp. 1098-1104
    • Terpos, E.1    Sezer, O.2    Croucher, P.3    Dimopoulos, M.-A.4
  • 6
    • 0041845297 scopus 로고    scopus 로고
    • E3 ubiquitin ligase Smurf1 mediates core-binding factor alpha1/Runx2 degradation and plays a specific role in osteoblast differentiation
    • DOI 10.1074/jbc.M304132200
    • Zhao M, Qiao M, Oyajobi BO, Mundy GR, Chen D. E3 ubiquitin ligase Smurf1 mediates core-binding factor alpha1/Runx2 degradation and plays a specific role in osteoblast differentiation. J Biol Chem. 2003;278:27939-27944. (Pubitemid 36899988)
    • (2003) Journal of Biological Chemistry , vol.278 , Issue.30 , pp. 27939-27944
    • Zhao, M.1    Qiao, M.2    Oyajobi, B.O.3    Mundy, G.R.4    Chen, D.5
  • 7
    • 0027980319 scopus 로고
    • Inhibitors of the proteasome block the degradation of most cell proteins and the generation of peptides presented on MHC class I molecules
    • DOI 10.1016/S0092-8674(94)90462-6
    • Rock KL, Gramm C, Rothstein L, et al. Inhibitors of the proteasome block the degradation of most cell proteins and the generation of peptides presented on MHC class I molecules. Cell. 1994;78:761-771. (Pubitemid 24294452)
    • (1994) Cell , vol.78 , Issue.5 , pp. 761-771
    • Rock, K.L.1    Gramm, C.2    Rothstein, L.3    Clark, K.4    Stein, R.5    Dick, L.6    Hwang, D.7    Goldberg, A.L.8
  • 9
    • 34250823973 scopus 로고    scopus 로고
    • Minireview: Targeting the Wnt/beta-catenin pathway to regulate bone formation in the adult skeleton
    • DOI 10.1210/en.2007-0270
    • Baron R, Rawadi G. Targeting the Wnt/beta-catenin pathway to regulate bone formation in the adult skeleton. Endocrinology. 2007;148:2635-2643. (Pubitemid 46984775)
    • (2007) Endocrinology , vol.148 , Issue.6 , pp. 2635-2643
    • Baron, R.1    Rawadi, G.2
  • 10
    • 33746808398 scopus 로고    scopus 로고
    • Wnt/beta-catenin signaling in development and disease
    • Clevers H. Wnt/beta-catenin signaling in development and disease. Cell. 2006;127:469-480.
    • (2006) Cell , vol.127 , pp. 469-480
    • Clevers, H.1
  • 11
    • 0032406715 scopus 로고    scopus 로고
    • Mechanisms of Wnt signaling in development
    • Wodarz A, Nusse R. Mechanisms of Wnt signaling in development. Annu Rev Cell Dev Biol. 1998;14:59-88.
    • (1998) Annu Rev Cell Dev Biol , vol.14 , pp. 59-88
    • Wodarz, A.1    Nusse, R.2
  • 12
    • 60249086335 scopus 로고    scopus 로고
    • The role of Dickkopf-1 in bone development, homeostasis, and disease
    • Pinzone JJ, Hall BM, Thudi NK, et al. The role of Dickkopf-1 in bone development, homeostasis, and disease. Blood. 2009;113:517-525.
    • (2009) Blood , vol.113 , pp. 517-525
    • Pinzone, J.J.1    Hall, B.M.2    Thudi, N.K.3
  • 13
    • 17844372752 scopus 로고    scopus 로고
    • Wnt/beta-catenin signaling in mesenchymal progenitors controls osteoblast and chondrocyte differentiation during vertebrate skeletogenesis
    • DOI 10.1016/j.devcel.2005.03.016, PII S1534580705001061
    • Day TF, Guo X, Garrett-Beal L, Yang Y. Wnt/ beta-catenin signaling in mesenchymal progenitors controls osteoblast and chondrocyte differentiation during vertebrate skeletogenesis. Dev Cell. 2005;8:739-750. (Pubitemid 40585296)
    • (2005) Developmental Cell , vol.8 , Issue.5 , pp. 739-750
    • Day, T.F.1    Guo, X.2    Garrett-Beal, L.3    Yang, Y.4
  • 14
    • 17844363974 scopus 로고    scopus 로고
    • Canonical Wnt/beta-catenin signaling prevents osteoblasts from differentiating into chondrocytes
    • DOI 10.1016/j.devcel.2005.02.013, PII S1534580705000870
    • Hill TP, Spater D, Taketo MM, Birchmeier W, Hartmann C. Canonical Wnt/beta-catenin signaling prevents osteoblasts from differentiating into chondrocytes. Dev Cell. 2005;8:727-738. (Pubitemid 40585295)
    • (2005) Developmental Cell , vol.8 , Issue.5 , pp. 727-738
    • Hill, T.P.1    Spater, D.2    Taketo, M.M.3    Birchmeier, W.4    Hartmann, C.5
  • 16
    • 20244373613 scopus 로고    scopus 로고
    • Canonical Wnt signaling in differentiated osteoblasts controls osteoclast differentiation
    • Glass DA 2nd, Bialek P, Ahn JD, et al. Canonical Wnt signaling in differentiated osteoblasts controls osteoclast differentiation. Dev Cell. 2005;8:751-764.
    • (2005) Dev Cell , vol.8 , pp. 751-764
    • Glass II, D.A.1    Bialek, P.2    Ahn, J.D.3
  • 17
    • 0038783316 scopus 로고    scopus 로고
    • Secreted antagonists of the Wnt signalling pathway
    • DOI 10.1242/jcs.00623
    • Kawano Y, Kypta R. Secreted antagonists of the Wnt signalling pathway. J Cell Sci. 2003;116:2627-2634. (Pubitemid 36857216)
    • (2003) Journal of Cell Science , vol.116 , Issue.13 , pp. 2627-2634
    • Kawano, Y.1    Kypta, R.2
  • 19
    • 40849083276 scopus 로고    scopus 로고
    • Dkk1-induced inhibition of Wnt signaling in osteoblast differentiation is an underlying mechanism of bone loss in multiple myeloma
    • Qiang YW, Barlogie B, Rudikoff S, Shaughnessy JD Jr. Dkk1-induced inhibition of Wnt signaling in osteoblast differentiation is an underlying mechanism of bone loss in multiple myeloma. Bone. 2008;42:669-680.
    • (2008) Bone , vol.42 , pp. 669-680
    • Qiang, Y.W.1    Barlogie, B.2    Rudikoff, S.3    Shaughnessy Jr., J.D.4
  • 20
    • 47249140444 scopus 로고    scopus 로고
    • Myeloma-derived Dickkopf-1 disrupts Wnt-regulated osteoprotegerin and RANKL production by osteoblasts: A potential mechanism underlying osteolytic bone lesions in multiple myeloma
    • Qiang YW, Chen Y, Stephens O, et al. Myeloma-derived Dickkopf-1 disrupts Wnt-regulated osteoprotegerin and RANKL production by osteoblasts: a potential mechanism underlying osteolytic bone lesions in multiple myeloma. Blood. 2008.
    • (2008) Blood
    • Qiang, Y.W.1    Chen, Y.2    Stephens, O.3
  • 22
    • 0033304730 scopus 로고    scopus 로고
    • Modulation of osteoclast differentiation and function by the new members of the tumor necrosis factor receptor and ligand families
    • Suda T, Takahashi N, Udagawa N, Jimi E, Gillespie MT, Martin TJ. Modulation of osteoclast differentiation and function by the new members of the tumor necrosis factor receptor and ligand families. Endocr Rev. 1999;20:345-357. (Pubitemid 30649812)
    • (1999) Endocrine Reviews , vol.20 , Issue.3 , pp. 345-357
    • Suda, T.1    Takahashi, N.2    Udagawa, N.3    Jimi, E.4    Gillespie, M.T.5    Martin, T.J.6
  • 23
    • 33646808104 scopus 로고    scopus 로고
    • Wnt signalling in osteoblasts regulates expression of the receptor activator of NFkappaB ligand and inhibits osteoclastogenesis in vitro
    • Spencer GJ, Utting JC, Etheridge SL, Arnett TR, Genever PG. Wnt signalling in osteoblasts regulates expression of the receptor activator of NFkappaB ligand and inhibits osteoclastogenesis in vitro. J Cell Sci. 2006;119:1283-1296.
    • (2006) J Cell Sci , vol.119 , pp. 1283-1296
    • Spencer, G.J.1    Utting, J.C.2    Etheridge, S.L.3    Arnett, T.R.4    Genever, P.G.5
  • 24
    • 41949093576 scopus 로고    scopus 로고
    • Increasing Wnt signaling in the bone marrow microenvironment inhibits the development of myeloma bone disease and reduces tumor burden in bone in vivo
    • Edwards CM, Edwards JR, Lwin ST, et al. Increasing Wnt signaling in the bone marrow microenvironment inhibits the development of myeloma bone disease and reduces tumor burden in bone in vivo. Blood. 2008;111:2833-2842.
    • (2008) Blood , vol.111 , pp. 2833-2842
    • Edwards, C.M.1    Edwards, J.R.2    Lwin, S.T.3
  • 25
    • 47649120741 scopus 로고    scopus 로고
    • Wnt3a signaling within bone inhibits multiple myeloma bone disease and tumor growth
    • Qiang YW, Shaughnessy JD Jr, Yaccoby S. Wnt3a signaling within bone inhibits multiple myeloma bone disease and tumor growth. Blood. 2008;112:374-382.
    • (2008) Blood , vol.112 , pp. 374-382
    • Qiang, Y.W.1    Shaughnessy Jr., J.D.2    Yaccoby, S.3
  • 26
    • 33847397091 scopus 로고    scopus 로고
    • Antibody-based inhibition of DKK1 suppresses tumor-induced bone resorption and multiple myeloma growth in vivo
    • DOI 10.1182/blood-2006-09-047712
    • Yaccoby S, Ling W, Zhan F, Walker R, Barlogie B, Shaughnessy JD Jr. Antibody-based inhibition of DKK1 suppresses tumor-induced bone resorption and multiple myeloma growth in vivo. Blood. 2007;109:2106-2111. (Pubitemid 46348212)
    • (2007) Blood , vol.109 , Issue.5 , pp. 2106-2111
    • Yaccoby, S.1    Ling, W.2    Zhan, F.3    Walker, R.4    Barlogie, B.5    Shaughnessy Jr., J.D.6
  • 27
    • 0030889354 scopus 로고    scopus 로고
    • Marrow stromal cells as stem cells for nonhematopoietic tissues
    • DOI 10.1126/science.276.5309.71
    • Prockop DJ. Marrow stromal cells as stem cells for nonhematopoietic tissues. Science. 1997;276:71-74. (Pubitemid 27161245)
    • (1997) Science , vol.276 , Issue.5309 , pp. 71-74
    • Prockop, D.J.1
  • 28
    • 0036625066 scopus 로고    scopus 로고
    • Insulinlike growth factor-I signaling in multiple myeloma: Downstream elements, functional correlates, and pathway cross-talk
    • DOI 10.1182/blood.V99.11.4138
    • Qiang Y, Kopantzev E, Rudikoff S. Insulinlike growth factor-I signaling in multiple myeloma: downstream elements, functional correlates, and pathway cross-talk. Blood. 2002;99:4138-4146. (Pubitemid 35332058)
    • (2002) Blood , vol.99 , Issue.11 , pp. 4138-4146
    • Qiang, Y.-W.1    Kopantzev, E.2    Rudikoff, S.3
  • 30
    • 0032575093 scopus 로고    scopus 로고
    • Characterization of Wnt-1 and Wnt-2 induced growth alterations and signaling pathways in NIH3T3 fibroblasts
    • Bafico A, Gazit A, Wu-Morgan SS, Yaniv A, Aaronson SA. Characterization of Wnt-1 and Wnt-2 induced growth alterations and signaling pathways in NIH3T3 fibroblasts. Oncogene. 1998;16:2819-2825. (Pubitemid 28279349)
    • (1998) Oncogene , vol.16 , Issue.21 , pp. 2819-2825
    • Bafico, A.1    Gazit, A.2    Wu-Morgan, S.S.3    Yaniv, A.4    Aaronson, S.A.5
  • 31
    • 0033711709 scopus 로고    scopus 로고
    • Insulin-like growth factor-1 and -2 stimulate osteoprogenitor proliferation and differentiation and adipocyte formation in cell populations derived from adult rat bone
    • DOI 10.1016/S8756-3282(00)00400-2, PII S8756328200004002
    • Jia D, Heersche JN. Insulin-like growth factor-1 and -2 stimulate osteoprogenitor proliferation and differentiation and adipocyte formation in cell populations derived from adult rat bone. Bone. 2000;27:785-794. (Pubitemid 30953042)
    • (2000) Bone , vol.27 , Issue.6 , pp. 785-794
    • Jia, D.1    Heersche, J.N.M.2
  • 32
    • 2342559147 scopus 로고    scopus 로고
    • An Alizarin red-based assay of mineralization by adherent cells in culture: Comparison with cetylpyridinium chloride extraction
    • DOI 10.1016/j.ab.2004.02.002, PII S0003269704001332
    • Gregory CA, Gunn WG, Peister A, Prockop DJ. An Alizarin red-based assay of mineralization by adherent cells in culture: comparison with cetylpyridinium chloride extraction. Anal Biochem. 2004;329:77-84. (Pubitemid 38596903)
    • (2004) Analytical Biochemistry , vol.329 , Issue.1 , pp. 77-84
    • Gregory, C.A.1    Gunn, W.G.2    Peister, A.3    Prockop, D.J.4
  • 35
    • 0030978351 scopus 로고    scopus 로고
    • beta-catenin is a target for the ubiquitin-proteasome pathway
    • DOI 10.1093/emboj/16.13.3797
    • Aberle H, Bauer A, Stappert J, Kispert A, Kemler R. beta-catenin is a target for the ubiquitin-proteasome pathway. EMBO J. 1997;16:3797-3804. (Pubitemid 27280995)
    • (1997) EMBO Journal , vol.16 , Issue.13 , pp. 3797-3804
    • Aberle, H.1    Bauer, A.2    Stappert, J.3    Kispert, A.4    Kemler, R.5
  • 36
    • 0031012411 scopus 로고    scopus 로고
    • Osteogenic differentiation of purified, culture-expanded human mesenchymal stem cells in vitro
    • DOI 10.1002/(SICI)1097-4644(199702)64:2<295::AID-JCB12>3.0.CO;2-I
    • Jaiswal N, Haynesworth SE, Caplan AI, Bruder SP. Osteogenic differentiation of purified, culture-expanded human mesenchymal stem cells in vitro. J Cell Biochem. 1997;64:295-312. (Pubitemid 27065443)
    • (1997) Journal of Cellular Biochemistry , vol.64 , Issue.2 , pp. 295-312
    • Jaiswal, N.1    Haynesworth, S.E.2    Caplan, A.I.3    Bruder, S.P.4
  • 37
    • 0142241118 scopus 로고    scopus 로고
    • BMP-2 Controls Alkaline Phosphatase Expression and Osteoblast Mineralization by a Wnt Autocrine Loop
    • DOI 10.1359/jbmr.2003.18.10.1842
    • Rawadi G, Vayssiere B, Dunn F, Baron R, Roman-Roman S. BMP-2 controls alkaline phosphatase expression and osteoblast mineralization by a Wnt autocrine loop. J Bone Miner Res. 2003;18:1842-1853. (Pubitemid 37322562)
    • (2003) Journal of Bone and Mineral Research , vol.18 , Issue.10 , pp. 1842-1853
    • Rawadi, G.1    Vayssiere, B.2    Dunn, F.3    Baron, R.4    Roman-Roman, S.5
  • 38
    • 0033597886 scopus 로고    scopus 로고
    • Characterization of mouse dishevelled (Dvl) proteins in Wnt/Wingless signaling pathway
    • Lee JS, Ishimoto A, Yanagawa S. Characterization of mouse dishevelled (Dvl) proteins in Wnt/ Wingless signaling pathway. J Biol Chem. 1999;274:21464-21470. (Pubitemid 129519664)
    • (1999) Journal of Biological Chemistry , vol.274 , Issue.30 , pp. 21464-21470
    • Lee, J.-S.1    Ishimoto, A.2    Yanagawa, S.-I.3
  • 39
    • 0037383322 scopus 로고    scopus 로고
    • GSK-3: Tricks of the trade for a multi-tasking kinase
    • Doble BW, Woodgett JR. GSK-3: tricks of the trade for a multi-tasking kinase. J Cell Sci. 2003;116:1175-1186.
    • (2003) J Cell Sci , vol.116 , pp. 1175-1186
    • Doble, B.W.1    Woodgett, J.R.2
  • 40
    • 0030449964 scopus 로고    scopus 로고
    • Lithium inhibits glycogen synthase kinase-3 activity and mimics wingless signalling in intact cells
    • Stambolic V, Ruel L, Woodgett JR. Lithium inhibits glycogen synthase kinase-3 activity and mimics wingless signalling in intact cells. Curr Biol. 1996;6:1664-1668. (Pubitemid 27050234)
    • (1996) Current Biology , vol.6 , Issue.12 , pp. 1664-1668
    • Stambolic, V.1    Ruel, L.2    Woodgett, J.R.3
  • 41
    • 32944469894 scopus 로고    scopus 로고
    • Bortezomib: Proteasome inhibition as an effective anticancer therapy
    • DOI 10.1146/annurev.med.57.042905.122625
    • Richardson PG, Mitsiades C, Hideshima T, Anderson KC. Bortezomib: proteasome inhibition as an effective anticancer therapy. Annu Rev Med. 2006;57:33-47. (Pubitemid 43261977)
    • (2006) Annual Review of Medicine , vol.57 , pp. 33-47
    • Richardson, P.G.1    Mitsiades, C.2    Hideshima, T.3    Anderson, K.C.4
  • 44
    • 57849161431 scopus 로고    scopus 로고
    • The combination of bortezomib, melphalan, dexamethasone and intermittent thalidomide is an effective regimen for relapsed/refractory myeloma and is associated with improvement of abnormal bone metabolism and angiogenesis
    • Terpos E, Kastritis E, Roussou M, et al. The combination of bortezomib, melphalan, dexamethasone and intermittent thalidomide is an effective regimen for relapsed/refractory myeloma and is associated with improvement of abnormal bone metabolism and angiogenesis. Leukemia. 2008;22:2247-2256.
    • (2008) Leukemia , vol.22 , pp. 2247-2256
    • Terpos, E.1    Kastritis, E.2    Roussou, M.3
  • 48
    • 33745494534 scopus 로고    scopus 로고
    • A crosstalk between myeloma cells and marrow stromal cells stimulates production of DKK1 and interleukin-6: A potential role in the development of lytic bone disease and tumor progression in multiple myeloma
    • DOI 10.1634/stemcells.2005-0220
    • Gunn WG, Conley A, Deininger L, Olson SD, Prockop DJ, Gregory CA. A crosstalk between myeloma cells and marrow stromal cells stimulates production of DKK1 and interleukin-6: a potential role in the development of lytic bone disease and tumor progression in multiple myeloma. Stem Cells. 2006;24:986-991. (Pubitemid 44464731)
    • (2006) Stem Cells , vol.24 , Issue.4 , pp. 986-991
    • Gunn, W.G.1    Conley, A.2    Deininger, L.3    Olson, S.D.4    Prockop, D.J.5    Gregory, C.A.6
  • 50
    • 1542347695 scopus 로고    scopus 로고
    • Convergence of Wnt, beta-Catenin, and Cadherin pathways
    • DOI 10.1126/science.1094291
    • Nelson WJ, Nusse R. Convergence of Wnt, betacatenin, and cadherin pathways. Science. 2004;303:1483-1487. (Pubitemid 38314410)
    • (2004) Science , vol.303 , Issue.5663 , pp. 1483-1487
    • Nelson, W.J.1    Nusse, R.2
  • 51
    • 39649102756 scopus 로고    scopus 로고
    • R-spondin1 synergizes with Wnt3A in inducing osteoblast differentiation and osteoprotegerin expression
    • Lu W, Kim KA, Liu J, et al. R-spondin1 synergizes with Wnt3A in inducing osteoblast differentiation and osteoprotegerin expression. FEBS Lett. 2008;582:643-650.
    • (2008) FEBS Lett , vol.582 , pp. 643-650
    • Lu, W.1    Kim, K.A.2    Liu, J.3
  • 55
    • 0037097587 scopus 로고    scopus 로고
    • Immunocytochemistry reveals RANKL expression of myeloma cells
    • author reply 4647
    • Sezer O, Heider U, Jakob C, et al. Immunocytochemistry reveals RANKL expression of myeloma cells. Blood. 2002;99:4646-4647; author reply 4647.
    • (2002) Blood , vol.99 , pp. 4646-4647
    • Sezer, O.1    Heider, U.2    Jakob, C.3
  • 56
    • 0037443533 scopus 로고    scopus 로고
    • RANK ligand and osteoprotegerin in myeloma bone disease
    • DOI 10.1182/blood-2002-09-2684
    • Sezer O, Heider U, Zavrski I, Kuhne CA, Hofbauer LC. RANK ligand and osteoprotegerin in myeloma bone disease. Blood. 2003;101:2094-2098. (Pubitemid 36302042)
    • (2003) Blood , vol.101 , Issue.6 , pp. 2094-2098
    • Sezer, O.1    Heider, U.2    Zavrski, I.3    Kuhne, C.A.4    Hofbauer, L.C.5
  • 58
    • 0038675192 scopus 로고    scopus 로고
    • Interpreting the molecular biology and clinical behavior of multiple myeloma in the context of global gene expression profiling
    • DOI 10.1034/j.1600-065X.2003.00054.x
    • Shaughnessy JD Jr, Barlogie B. Interpreting the molecular biology and clinical behavior of multiple myeloma in the context of global gene expression profiling. Immunol Rev. 2003;194:140-163. (Pubitemid 36886434)
    • (2003) Immunological Reviews , vol.194 , pp. 140-163
    • Shaughnessy Jr., J.D.1    Barlogie, B.2
  • 59
    • 41549138806 scopus 로고    scopus 로고
    • Modulation of Dickkopf-1 attenuates glucocorticoid induction of osteoblast apoptosis, adipocytic differentiation, and bone mass loss
    • Wang FS, Ko JY, Yeh DW, Ke HC, Wu HL. Modulation of Dickkopf-1 attenuates glucocorticoid induction of osteoblast apoptosis, adipocytic differentiation, and bone mass loss. Endocrinology. 2008;149:1793-1801.
    • (2008) Endocrinology , vol.149 , pp. 1793-1801
    • Wang, F.S.1    Ko, J.Y.2    Yeh, D.W.3    Ke, H.C.4    Wu, H.L.5


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