Osteogenic growth peptide enhances the proliferation of bone marrow mesenchymal stem cells from osteoprotegerin-deficient mice by CDK2/cyclin A

Acta Biochimica et Biophysica Sinica

Volumn 42, Issue 11, 2010, Pages 801-806

  Fei, Qinming ^a   Guo, Changjun ^a   Xu, Xiaoya ^a   Gao, Jianjun ^a   Zhang, Jian ^a   Chen, Tongyi ^a   Cui, Dafu ^b  

^a FUDAN UNIVERSITY   (China)

^b INSTITUTE OF BIOCHEMISTRY AND CELL BIOLOGY   (China)

Author keywords

CDK2 cyclin A; cell proliferation; mesenchymal stem cell; osteogenic growth peptide; osteoprotegerin

Indexed keywords

ALKALINE PHOSPHATASE; CDK2 PROTEIN, MOUSE; CYCLIN A; CYCLIN DEPENDENT KINASE 2; HISTONE; OSTEOGENIC GROWTH PEPTIDE; OSTEOPROTEGERIN; SIGNAL PEPTIDE;

AMINO ACID SEQUENCE; ANIMAL; ARTICLE; BONE MARROW CELL; CELL CULTURE; CELL DIFFERENTIATION; CELL PROLIFERATION; DRUG EFFECT; GENE EXPRESSION; GENETICS; MALE; MESENCHYMAL STEM CELL; METABOLISM; MOUSE; MOUSE MUTANT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; SYNTHESIS; TIME; WESTERN BLOTTING;

ALKALINE PHOSPHATASE; AMINO ACID SEQUENCE; ANIMALS; BLOTTING, WESTERN; BONE MARROW CELLS; CELL DIFFERENTIATION; CELL PROLIFERATION; CELLS, CULTURED; CYCLIN A; CYCLIN-DEPENDENT KINASE 2; GENE EXPRESSION; HISTONES; INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS; MALE; MESENCHYMAL STEM CELLS; MICE; MICE, KNOCKOUT; OSTEOPROTEGERIN; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; TIME FACTORS;

MUS;

EID: 78049473824     PISSN: 16729145     EISSN: 17457270     Source Type: Journal    
DOI: 10.1093/abbs/gmq086     Document Type: Article

References (27)

1. Norman H. Advances in the treatment of osteoporosis. Curr Drug Targets-Immune, Endocr Metab Disord 2001, 1:93-102.
2. Bab I, Gazit D and Chorev M. Histone H4-related osteogenic culture peptide (OGP): a novel circulating stimulator of osteoblastic activity. EMBO 1992, 11:1867-1873.
3. Greenberg Z, Gavish H and Muhlrad A. Isolation of osteogenic culture peptide from osteoblastic MC3T3 E1 cell cultures and demonstration of osteogenic culture peptide binding proteins. J Cell Biochem 1997, 65:359-367.
4. Bab I and Chorev M. Osteogenic culture peptide: from concept to drug design. Biopolymers 2002, 66:33-48.
5. Gabet Y, Muller R and Regev E. Osteogenic growth peptide modulates fracture callus structural and mechanical properties. Bone 2004, 35:65-73.
6. Chen ZX and Chang M. Osteogenic culture peptide C-terminal pentapeptide [OGP] acts on rat bone marrow mesenchymal stem cells to promote differentiation to osteoblasts and to inhibit differentiation to adipocytes. Regul Pept 2007, 142:16-23.
7. Fei QM, Cui DF and Chen TY. Synthetic osteogenic growth peptide stimulates osteoblast osteogenic activity and enhances fracture healing in rabbits. Acta Biochim Biophys Sin 2001, 33:415-420.
8. Fei QM, Chen TY and Cui DF. The effect of synthetic osteogenic growth peptide on tibia fracture healing in rabbits. Chin J Orthop 2002, 22:165-170.
9. Mizuno A, Amizuk N and Irie K. Severe osteoporosis in mice lacking osteocastogenesis inhibitory factor/osteoprotegerin. Biochem Biophys Res Commun 1998, 247:610-615.
10. Suda T, Takahashi N and Udagawa N. Modulation of osteoclast differentiation and function by the new members of the tumor necrosis factor receptor and ligand families. Endocr Rev 1999, 20:345-357.
11. Bucay N, Sarosi I and Dunstan CR. Osteoprotegerin-deficient mice develop early onset osteoporosis and arterial calcification. Genes Dev 1998, 12:1260-1268.
12. Spreafico A, Frediani B and Capperucci C. Osteogenic growth peptide effects on primary human osteoblast cultures: potential relevance for the treatment of glucocorticoid-induced osteoporosis. J Cell Biochem 2006, 98:1007-1020.
13. Chen ZX. Osteogenesis and adipogenesis role of synthetic osteogenic growth peptide on human bone marrow mesenchymal stem cells via RhoA/ROCK pathway and its effect in osteoprotegerin deficient mice in vivo. Ph. D. Thesis. Fudan University, 2007.
14. Wozney JM, Rosen V and Celeste AJ. Novel regulators of bone formation: molecular clones and activities. Science 1988, 242:1528-1534.
15. Wang EA, Rosen VD and Alessandro JS. Recombinant human bone morphogenetic protein induces bone formation. Proc Natl Acad Sci USA 1990, 87:2220-2224.
16. Service RF. Tissue engineers build new bone. Science 2000, 289:1498-1500.
17. Liu ZH, Li MY and Cui DF. A novel method for polypeptide design to prepare specific antibody of the peptide and applied to immunoassay. J Immunol Methods 2003, 281:17-25.
18. Prockop DJ. Marrow stromal cells as stem cells for nonhematopoietic tissues. Science 1997, 276:71-74.
19. Wang HF, Jin WF and Gao JJ. Osteoblast culture techniques in vitro. In: Wang HF ed. An Atlas of Bone Cells and Cell Culture Techniques. Shanghai: Shanghai Scientific and Technical Publishers, 2001.
20. Wang HF, Jin WF, Gao JJ and Sheng H. Osteoblast culture and pharmacological evaluation in vitro. In: Leung KS, Qin YX and Cheung WH eds. A Practical Manual for Musculoskeletal Research. Singapore: World Scientific Publishing, 2008.
21. Fei QM, Boden SD, Sangadala S, Viggeswarapu M, Liu Y and Titus L. Truncated human LMP-1 triggers differentiation of C2C12 cells to an osteoblastic phenotype in vitro. Acta Biochim Biophys Sin 2007, 39:693-700.
22. Sun YQ and Ashhurst DE. Osteogenic growth peptide enhances the rate of fracture healing in rabbits. Cell Biol Int 1998, 22:313-319.
23. Brager MA, Patterson MJ, Connolly JF and Nevo Z. Osteogenic growth peptide normally stimulated by blood loss and marrow ablation has local and systemic effects on fracture healing in rats. J Orthop Res 2000, 18:133-139.
24. Robinson D, Bab I and Nevo Z. Osteogenic culture peptide regulates proliferation and osteogenic maturation of human and rabbit bone marrow stromal cells. J Bone Miner Res 1995, 5:690-696.
25. Heichman KA and Roberts JM. Rules to replicate by. Cell 1994, 79:557-562.
26. Karsenty G. Minireview: transcriptional control of osteoblast differentiation. Endocrinology 2001, 142:2731-2733.
27. Nishimura R, Hata K and Ikeda F. Signal transduction and transcriptional regulation during mesenchymal cell differention. J Bone Miner Metab 2008, 26:203-212.