Thrombin peptide (TP508) promotes fracture repair by up-regulating inflammatory mediators, early growth factors, and increasing angiogenesis

Journal of Orthopaedic Research

Volumn 23, Issue 3, 2005, Pages 671-679

  Wang, Hali ^a   Li, Xinmin ^b   Tomin, Emre ^c   Doty, Stephen B ^c   Lane, Joseph M ^c   Carney, Darrell H ^d   Ryaby, James T ^a  

^a OrthoLogic Corporation   (United States)

^b UNIVERSITY OF CHICAGO   (United States)

^c HOSPITAL FOR SPECIAL SURGERY   (United States)

^d UNIVERSITY OF TEXAS MEDICAL BRANCH   (United States)

Author keywords

Angiogenesis; Early growth factors; Fracture repair; Gene expression; Microarray analysis; TP508

Indexed keywords

CHRYSALIN; CYTOKINE; EARLY GROWTH RESPONSE FACTOR 1; GROWTH FACTOR; THROMBIN; TP 508; UNCLASSIFIED DRUG;

ANALYSIS OF VARIANCE; ANGIOGENESIS; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BIOMECHANICS; BONE STRENGTH; CALLUS; CONTROLLED STUDY; DNA MICROARRAY; DRUG MECHANISM; FEMUR FRACTURE; FRACTURE HEALING; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; GENOME ANALYSIS; HISTOPATHOLOGY; IMMUNE RESPONSE; INFLAMMATION; KRUSKAL WALLIS TEST; MALE; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; RAT; RAT STRAIN; REAL TIME POLYMERASE CHAIN REACTION; RECEPTOR UPREGULATION; RNA EXTRACTION; TISSUE REPAIR; WOUND HEALING;

ANIMALS; BIOMECHANICS; FRACTURE HEALING; GENE EXPRESSION REGULATION; GROWTH SUBSTANCES; INFLAMMATION MEDIATORS; MALE; NEOVASCULARIZATION, PHYSIOLOGIC; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; PEPTIDE FRAGMENTS; RATS; RATS, SPRAGUE-DAWLEY; THROMBIN; UP-REGULATION;

EID: 18244410123     PISSN: 07360266     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.orthres.2004.10.002     Document Type: Article

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