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Volumn 95, Issue 4, 2010, Pages 1496-1504

Update in new anabolic therapies for osteoporosis

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVIN; ACTIVIN RECEPTOR; ANABOLIC AGENT; BETA CATENIN; BONE MORPHOGENETIC PROTEIN; DICKKOPF 1 PROTEIN; GROWTH FACTOR; GROWTH FACTOR RECEPTOR; PARATHYROID HORMONE; PROTEASOME INHIBITOR; SCLEROSTIN; SECRETED FRIZZLED RELATED PROTEIN 1; SOMATOMEDIN BINDING PROTEIN 1; WNT PROTEIN; SOMATOMEDIN C;

EID: 77951624097     PISSN: 0021972X     EISSN: 0021972X     Source Type: Journal    
DOI: 10.1210/jc.2009-2677     Document Type: Review
Times cited : (75)

References (77)
  • 2
    • 14844328960 scopus 로고    scopus 로고
    • Bone remodeling increases substantially in the years after menopause and remains increased in older osteoporosis patients
    • DOI 10.1359/JBMR.040710
    • Recker R, Lappe J, Davies KM, Heaney R 2004 Bone remodeling increases substantially in the years after menopause and remains increased in older osteoporosis patients. J Bone Miner Res 19: 1628-1633 (Pubitemid 41094325)
    • (2004) Journal of Bone and Mineral Research , vol.19 , Issue.10 , pp. 1628-1633
    • Recker, R.1    Lappe, J.2    Davies, K.M.3    Heaney, R.4
  • 3
    • 0034873321 scopus 로고    scopus 로고
    • The bone remodeling compartment: A circulatory function for bone lining cells
    • Parfitt AM 2001 The bone remodeling compartment: a circulatory function for bone lining cells. J Bone Miner Res 16:1583-1585
    • (2001) J Bone Miner Res , vol.16 , pp. 1583-1585
    • Parfitt, A.M.1
  • 4
    • 18344396116 scopus 로고    scopus 로고
    • The fate of circulating osteoblasts
    • Canalis E 2005 The fate of circulating osteoblasts. N Engl J Med 352:2014-2016
    • (2005) N Engl J Med , vol.352 , pp. 2014-2016
    • Canalis, E.1
  • 5
    • 59549087562 scopus 로고    scopus 로고
    • Skeletal growth factors
    • Marcus R, Feldman D, Nelson D, Rosen C, eds. 3rd ed. San Diego: Academic Press
    • Canalis E 2007 Skeletal growth factors. In: Marcus R, Feldman D, Nelson D, Rosen C, eds. Osteoporosis, 3rd ed. San Diego: Academic Press; 529-546
    • (2007) Osteoporosis , pp. 529-546
    • Canalis, E.1
  • 6
    • 0242668869 scopus 로고    scopus 로고
    • Bone morphogenetic proteins, their antagonists, and the skeleton
    • DOI 10.1210/er.2002-0023
    • Canalis E, Economides AN, Gazzerro E 2003 Bone morphogenetic proteins, their antagonists, and the skeleton. Endocr Rev 24:218-235 (Pubitemid 36515285)
    • (2003) Endocrine Reviews , vol.24 , Issue.2 , pp. 218-235
    • Canalis, E.1    Economides, A.N.2    Gazzerro, E.3
  • 9
    • 33846004405 scopus 로고    scopus 로고
    • Bone morphogenetic proteins and their antagonists
    • DOI 10.1007/s11154-006-9000-6, Special Issue on Osteoporosis
    • Gazzerro E, Canalis E 2006 Bone morphogenetic proteins and their antagonists. Rev Endocr Metab Disord 7:51-65 (Pubitemid 46044349)
    • (2006) Reviews in Endocrine and Metabolic Disorders , vol.7 , Issue.1-2 , pp. 51-65
    • Gazzerro, E.1    Canalis, E.2
  • 10
    • 0038783316 scopus 로고    scopus 로고
    • Secreted antagonists of the Wnt signalling pathway
    • DOI 10.1242/jcs.00623
    • Kawano Y, Kypta R 2003 Secreted antagonists of the Wnt signalling pathway. J Cell Sci 116:2627-2634 (Pubitemid 36857216)
    • (2003) Journal of Cell Science , vol.116 , Issue.13 , pp. 2627-2634
    • Kawano, Y.1    Kypta, R.2
  • 11
    • 0034864799 scopus 로고    scopus 로고
    • Proteasome inhibitors: From research tools to drug candidates
    • Kisselev AF, Goldberg AL 2001 Proteasome inhibitors: from research tools to drug candidates. Chem Biol 8:739-758
    • (2001) Chem Biol , vol.8 , pp. 739-758
    • Kisselev, A.F.1    Goldberg, A.L.2
  • 13
    • 5044228112 scopus 로고    scopus 로고
    • Wnt signaling in osteoblasts and bone diseases
    • Westendorf JJ, Kahler RA, Schroeder TM 2004 Wnt signaling in osteoblasts and bone diseases. Gene 341:19-39
    • (2004) Gene , vol.341 , pp. 19-39
    • Westendorf, J.J.1    Kahler, R.A.2    Schroeder, T.M.3
  • 14
    • 33845802651 scopus 로고    scopus 로고
    • Noncanonical Wnt Signaling through G Protein-Linked PKCδ Activation Promotes Bone Formation
    • DOI 10.1016/j.devcel.2006.11.003, PII S1534580706005089
    • Tu X, Joeng KS, Nakayama KI, Nakayama K, Rajagopal J, Carroll TJ, McMahon AP, Long F 2007 Noncanonical Wnt signaling through G protein-linked PKCδ activation promotes bone formation. Dev Cell 12:113-127 (Pubitemid 46002598)
    • (2007) Developmental Cell , vol.12 , Issue.1 , pp. 113-127
    • Tu, X.1    Joeng, K.S.2    Nakayama, K.I.3    Nakayama, K.4    Rajagopal, J.5    Carroll, T.6    McMahon, A.P.7    Long, F.8
  • 15
    • 29244446792 scopus 로고    scopus 로고
    • Wnt proteins prevent apoptosis of both uncommitted osteoblast progenitors and differentiated osteoblasts by β-catenin-dependent and -independent signaling cascades involving Src/ERK and phosphatidylinositol 3-kinase/AKT
    • Almeida M, Han L, Bellido T, Manolagas SC, Kousteni S 2005 Wnt proteins prevent apoptosis of both uncommitted osteoblast progenitors and differentiated osteoblasts by β-catenin-dependent and -independent signaling cascades involving Src/ERK and phosphatidylinositol 3-kinase/AKT. J Biol Chem 280:41342-41351
    • (2005) J Biol Chem , vol.280 , pp. 41342-41351
    • Almeida, M.1    Han, L.2    Bellido, T.3    Manolagas, S.C.4    Kousteni, S.5
  • 16
    • 0043234811 scopus 로고    scopus 로고
    • Wnt-5a inhibits the canonical Wnt pathway by promoting GSK-3-independent β-catenin degradation
    • DOI 10.1083/jcb.200303158
    • Topol L, Jiang X, Choi H, Garrett-Beal L, Carolan PJ, Yang Y 2003 Wnt-5a inhibits the canonical Wnt pathway by promoting GSK-3- independent β-catenin degradation. J Cell Biol 162:899-908 (Pubitemid 37087729)
    • (2003) Journal of Cell Biology , vol.162 , Issue.5 , pp. 899-908
    • Topol, L.1    Jiang, X.2    Choi, H.3    Garrett-Beal, L.4    Carolan, P.J.5    Yang, Y.6
  • 20
    • 12544250379 scopus 로고    scopus 로고
    • Glucocorticoids inhibit the transcriptional activity of LEF/TCF in differentiating osteoblasts in a glycogen synthase kinase-3β-dependent and -independent manner
    • Smith E, Frenkel B 2005 Glucocorticoids inhibit the transcriptional activity of LEF/TCF in differentiating osteoblasts in a glycogen synthase kinase-3β-dependent and -independent manner. J Biol Chem 280:2388-2394
    • (2005) J Biol Chem , vol.280 , pp. 2388-2394
    • Smith, E.1    Frenkel, B.2
  • 21
  • 24
    • 21844467220 scopus 로고    scopus 로고
    • SOST is a target gene for PTH in bone
    • DOI 10.1016/j.bone.2005.03.018, PII S8756328205001171
    • Keller H, Kneissel M 2005 SOST is a target gene for PTH in bone. Bone 37:148-158 (Pubitemid 40962421)
    • (2005) Bone , vol.37 , Issue.2 , pp. 148-158
    • Keller, H.1    Kneissel, M.2
  • 25
    • 26844521277 scopus 로고    scopus 로고
    • Chronic elevation of parathyroid hormone in mice reduces expression of sclerostin by osteocytes: A novel mechanism for hormonal control of osteoblastogenesis
    • DOI 10.1210/en.2005-0239
    • Bellido T, Ali AA, Gubrij I, Plotkin LI, Fu Q, O'Brien CA, Manolagas SC, Jilka RL 2005 Chronic elevation of parathyroid hormone in mice reduces expression of sclerostin by osteocytes: a novel mechanism for hormonal control of osteoblastogenesis. Endocrinology 146:4577-4583 (Pubitemid 41446595)
    • (2005) Endocrinology , vol.146 , Issue.11 , pp. 4577-4583
    • Bellido, T.1    Ali, A.A.2    Gubrij, I.3    Plotkin, L.I.4    Fu, Q.5    O'Brien, C.A.6    Manolagas, S.C.7    Jilka, R.L.8
  • 30
    • 0032994043 scopus 로고    scopus 로고
    • Signal transduction by bone morphogenetic protein receptors: Functional roles of Smad proteins
    • DOI 10.1016/S8756-3282(99)00113-1, PII S8756328299001131
    • Miyazono K 1999 Signal transduction by bone morphogenetic protein receptors: functional roles of Smad proteins. Bone 25:91-93 (Pubitemid 29322068)
    • (1999) Bone , vol.25 , Issue.1 , pp. 91-93
    • Miyazono, K.1
  • 31
    • 0033800431 scopus 로고    scopus 로고
    • Direct stimulation of osteoclastic bone resorption by bone morphogenetic protein (BMP)-2 and expression of BMP receptors in mature osteoclasts
    • Kaneko H, Arakawa T, Mano H, Kaneda T, Ogasawara A, Nakagawa M, Toyama Y, Yabe Y, Kumegawa M, Hakeda Y 2000 Direct stimulation of osteoclastic bone resorption by bone morphogenetic protein (BMP)-2 and expression of BMP receptors in mature osteoclasts. Bone 27:479-486
    • (2000) Bone , vol.27 , pp. 479-486
    • Kaneko, H.1    Arakawa, T.2    Mano, H.3    Kaneda, T.4    Ogasawara, A.5    Nakagawa, M.6    Toyama, Y.7    Yabe, Y.8    Kumegawa, M.9    Hakeda, Y.10
  • 32
    • 0025977099 scopus 로고
    • Activin-A Binding and Biochemical Effects in Osteoblast-Enriched Cultures from Fetal-Rat Parietal Bone
    • Centrella M, McCarthy TL, Canalis E 1991 Activin-A binding and biochemical effects in osteoblast-enriched cultures from fetal-rat parietal bone. Mol Cell Biol 11:250-258 (Pubitemid 21895202)
    • (1991) Molecular and Cellular Biology , vol.11 , Issue.1 , pp. 250-258
    • Centrella, M.1    McCarthy, T.L.2    Canalis, E.3
  • 33
    • 0036144102 scopus 로고    scopus 로고
    • Inhibin suppresses and activin stimulates osteoblastogenesis and osteoclastogenesis in murine bone marrow cultures
    • DOI 10.1210/en.143.1.74
    • Gaddy-Kurten D, Coker JK, Abe E, Jilka RL, Manolagas SC 2002 Inhibin suppresses and activin stimulates osteoblastogenesis and osteoclastogenesis in murine bone marrow cultures. Endocrinology 143:74-83 (Pubitemid 34056405)
    • (2002) Endocrinology , vol.143 , Issue.1 , pp. 74-83
    • Gaddy-Kurten, D.1    Coker, J.K.2    Abe, E.3    Jilka, R.L.4    Manolagas, S.C.5
  • 35
    • 0037733130 scopus 로고    scopus 로고
    • Skeletal overexpression of noggin results in osteopenia and reduced bone formation
    • DOI 10.1210/en.2002-220918
    • Devlin RD, Du Z, Pereira RC, Kimble RB, Economides AN, Jorgetti V, Canalis E 2003 Skeletal overexpression of noggin results in osteopenia and reduced bone formation. Endocrinology 144: 1972-1978 (Pubitemid 36543336)
    • (2003) Endocrinology , vol.144 , Issue.5 , pp. 1972-1978
    • Devlin, R.D.1    Du, Z.2    Pereira, R.C.3    Kimble, R.B.4    Economides, A.N.5    Jorgetti, V.6    Canalis, E.7
  • 36
    • 12344262661 scopus 로고    scopus 로고
    • Skeletal overexpression of gremlin impairs bone formation and causes osteopenia
    • DOI 10.1210/en.2004-0766
    • Gazzerro E, Pereira RC, Jorgetti V, Olson S, Economides AN, Canalis E 2005 Skeletal overexpression of gremlin impairs bone formation and causes osteopenia. Endocrinology 146:655-665 (Pubitemid 40129821)
    • (2005) Endocrinology , vol.146 , Issue.2 , pp. 655-665
    • Gazzerro, E.1    Pereira, R.C.2    Jorgetti, V.3    Olson, S.4    Economides, A.N.5    Canalis, E.6
  • 38
    • 64949178482 scopus 로고    scopus 로고
    • Bone morphogenetic protein-7 and gremlin: New emerging therapeutic targets for diabetic nephropathy
    • Zhang Y, Zhang Q 2009 Bone morphogenetic protein-7 and gremlin: new emerging therapeutic targets for diabetic nephropathy. Biochem Biophys Res Commun 383:1-3
    • (2009) Biochem Biophys Res Commun , vol.383 , pp. 1-3
    • Zhang, Y.1    Zhang, Q.2
  • 39
    • 0032239547 scopus 로고    scopus 로고
    • Pathophysiology of the neuroregulation of growth hormone secretion in experimental animals and the human
    • Giustina A, Veldhuis JD 1998 Pathophysiology of the neuroregulation of growth hormone secretion in experimental animals and the human. Endocr Rev 19:717-797
    • (1998) Endocr Rev , vol.19 , pp. 717-797
    • Giustina, A.1    Veldhuis, J.D.2
  • 40
    • 0024532580 scopus 로고
    • Insulin-like growth factor I mediates selective anabolic effects of parathyroid hormone in bone cultures
    • Canalis E, Centrella M, Burch W, McCarthy TL 1989 Insulin-like growth factor I mediates selective anabolic effects of parathyroid hormone in bone cultures. J Clin Invest 83:60-65
    • (1989) J Clin Invest , vol.83 , pp. 60-65
    • Canalis, E.1    Centrella, M.2    Burch, W.3    McCarthy, T.L.4
  • 41
    • 0034807415 scopus 로고    scopus 로고
    • Evidence that anabolic effects of PTH on bone require IGF-I in growing mice
    • DOI 10.1210/en.142.10.4349
    • Miyakoshi N, Kasukawa Y, Linkhart TA, Baylink DJ, Mohan S 2001 Evidence that anabolic effects of PTH on bone require IGF-I in growing mice. Endocrinology 142:4349-4356 (Pubitemid 32907063)
    • (2001) Endocrinology , vol.142 , Issue.10 , pp. 4349-4356
    • Miyakoshi, N.1    Kasukawa, Y.2    Linkhart, T.A.3    Baylink, D.J.4    Mohan, S.5
  • 44
    • 0242721096 scopus 로고    scopus 로고
    • Parallel Phosphatidylinositol-3 Kinase and p42/44 Mitogen-Activated Protein Kinase Signaling Pathways Subserve the Mitogenic and Antiapoptotic Actions of Insulin-Like Growth Factor I in Osteoblastic Cells
    • DOI 10.1210/en.2003-0350
    • Grey A, Chen Q, Xu X, Callon K, Cornish J 2003 Parallel phosphatidylinositol- 3 kinase and p42/44 mitogen-activated protein kinase signaling pathways subserve the mitogenic and antiapoptotic actions of insulin-like growth factor I in osteoblastic cells. Endocrinology 144:4886-4893 (Pubitemid 37378403)
    • (2003) Endocrinology , vol.144 , Issue.11 , pp. 4886-4893
    • Grey, A.1    Chen, Q.2    Xin, X.3    Callon, K.4    Cornish, J.5
  • 45
    • 0037064055 scopus 로고    scopus 로고
    • Wnt signaling protects 3T3-L1 preadipocytes from apoptosis through induction of insulin-like growth factors
    • Longo KA, Kennell JA, Ochocinska MJ, Ross SE, Wright WS, MacDougald OA 2002 Wnt signaling protects 3T3-L1 preadipocytes from apoptosis through induction of insulin-like growth factors. J Biol Chem 277:38239-38244
    • (2002) J Biol Chem , vol.277 , pp. 38239-38244
    • Longo, K.A.1    Kennell, J.A.2    Ochocinska, M.J.3    Ross, S.E.4    Wright, W.S.5    MacDougald, O.A.6
  • 57
    • 33646550902 scopus 로고    scopus 로고
    • Notch 1 overexpression inhibits osteoblastogenesis by suppressing Wnt/β-catenin but not bone morphogenetic protein signaling
    • DOI 10.1074/jbc.M508370200
    • Deregowski V, Gazzerro E, Priest L, Rydziel S, Canalis E 2006 Notch 1 overexpression inhibits osteoblastogenesis by suppressing Wnt/β-catenin but not bone morphogenetic protein signaling. J Biol Chem 281:6203-6210 (Pubitemid 43847550)
    • (2006) Journal of Biological Chemistry , vol.281 , Issue.10 , pp. 6203-6210
    • Deregowski, V.1    Gazzerro, E.2    Priest, L.3    Rydziel, S.4    Canalis, E.5
  • 58
    • 55449097835 scopus 로고    scopus 로고
    • Skeletal effects of central nervous system active drugs: Anxiolytics, sedatives, antidepressants, lithium and neuroleptics
    • Vestergaard P 2008 Skeletal effects of central nervous system active drugs: anxiolytics, sedatives, antidepressants, lithium and neuroleptics. Curr Drug Saf 3:185-189
    • (2008) Curr Drug Saf , vol.3 , pp. 185-189
    • Vestergaard, P.1
  • 61
    • 41949093576 scopus 로고    scopus 로고
    • Increasing Wnt signaling in the bone marrow microenvironment inhibits the development of myeloma bone disease and reduces tumor burden in bone in vivo
    • Edwards CM, Edwards JR, Lwin ST, Esparza J, Oyajobi BO, McCluskey B, Munoz S, Grubbs B, Mundy GR 2008 Increasing Wnt signaling in the bone marrow microenvironment inhibits the development of myeloma bone disease and reduces tumor burden in bone in vivo. Blood 111:2833-2842
    • (2008) Blood , vol.111 , pp. 2833-2842
    • Edwards, C.M.1    Edwards, J.R.2    Lwin, S.T.3    Esparza, J.4    Oyajobi, B.O.5    McCluskey, B.6    Munoz, S.7    Grubbs, B.8    Mundy, G.R.9
  • 64
    • 49549111375 scopus 로고    scopus 로고
    • Growth hormone, insulin-like growth factors, and the skeleton
    • Giustina A, Mazziotti G, Canalis E 2008 Growth hormone, insulin-like growth factors, and the skeleton. Endocr Rev 29:535-559
    • (2008) Endocr Rev , vol.29 , pp. 535-559
    • Giustina, A.1    Mazziotti, G.2    Canalis, E.3
  • 65
    • 0032452531 scopus 로고    scopus 로고
    • Association between insulin-like growth factor I and bone mineral density in older women and men: The Framingham Heart Study
    • Langlois JA, Rosen CJ, Visser M, Hannan MT, Harris T, Wilson PW, Kiel DP 1998 Association between insulin-like growth factor I and bone mineral density in older women and men: the Framingham Heart Study. J Clin Endocrinol Metab 83:42574262
    • (1998) J Clin Endocrinol Metab , vol.83 , pp. 42574262
    • Langlois, J.A.1    Rosen, C.J.2    Visser, M.3    Hannan, M.T.4    Harris, T.5    Wilson, P.W.6    Kiel, D.P.7
  • 66
    • 0029799208 scopus 로고    scopus 로고
    • Effects of short-term recombinant human insulin-like growth factor I administration on bone turnover in osteopenic women with anorexia nervosa
    • DOI 10.1210/jc.81.11.3864
    • Grinspoon S, Baum H, Lee K, Anderson E, Herzog D, Klibanski A 1996 Effects of short-term recombinant human insulin-like growth factor I administration on bone turnover in osteopenic women with anorexia nervosa. J Clin Endocrinol Metab 81:3864-3870 (Pubitemid 26380388)
    • (1996) Journal of Clinical Endocrinology and Metabolism , vol.81 , Issue.11 , pp. 3864-3870
    • Grinspoon, S.1    Baum, H.2    Lee, K.3    Anderson, E.4    Herzog, D.5    Klibanski, A.6
  • 68
    • 0036078286 scopus 로고    scopus 로고
    • Effects of recombinant human IGF-I and oral contraceptive administration on bone density in anorexia nervosa
    • DOI 10.1210/jc.87.6.2883
    • Grinspoon S, Thomas L, Miller K, Herzog D, Klibanski A 2002 Effects of recombinant human IGF-I and oral contraceptive administration on bone density in anorexia nervosa. J Clin Endocrinol Metab 87:2883-2891 (Pubitemid 34655358)
    • (2002) Journal of Clinical Endocrinology and Metabolism , vol.87 , Issue.6 , pp. 2883-2891
    • Grinspoon, S.1    Thomas, L.2    Miller, K.3    Herzog, D.4    Klibanski, A.5
  • 70
    • 33645330427 scopus 로고    scopus 로고
    • Increased prevalence of radiological spinal deformities in adult patients with GH deficiency: Influence of GH replacement therapy
    • Mazziotti G, Bianchi A, Bonadonna S, Nuzzo M, Cimino V, Fusco A, De Marinis L, Giustina A 2006 Increased prevalence of radiological spinal deformities in adult patients with GH deficiency: influence of GH replacement therapy. J Bone Miner Res 21:520-528
    • (2006) J Bone Miner Res , vol.21 , pp. 520-528
    • Mazziotti, G.1    Bianchi, A.2    Bonadonna, S.3    Nuzzo, M.4    Cimino, V.5    Fusco, A.6    De Marinis, L.7    Giustina, A.8
  • 74
    • 34248577022 scopus 로고    scopus 로고
    • Molecular and cellular mechanisms of the anabolic effect of intermittent PTH
    • Jilka RL 2007 Molecular and cellular mechanisms of the anabolic effect of intermittent PTH. Bone 40:1434-1446
    • (2007) Bone , vol.40 , pp. 1434-1446
    • Jilka, R.L.1
  • 76
    • 0037323386 scopus 로고    scopus 로고
    • Short-term, high-dose parathyroid hormone-related protein as a skeletal anabolic agent for the treatment of postmenopausal osteoporosis
    • Horwitz MJ, Tedesco MB, Gundberg C, Garcia-Ocana A, Stewart AF 2003 Short-term, high-dose parathyroid hormone-related protein as a skeletal anabolic agent for the treatment of postmenopausal osteoporosis. J Clin Endocrinol Metab 88:569-575
    • (2003) J Clin Endocrinol Metab , vol.88 , pp. 569-575
    • Horwitz, M.J.1    Tedesco, M.B.2    Gundberg, C.3    Garcia-Ocana, A.4    Stewart, A.F.5
  • 77
    • 70350555320 scopus 로고    scopus 로고
    • Effects of teriparatide versus alendronate for treating glucocorticoid-induced osteoporosis: Thirtysix- month results of a randomized, double-blind, controlled trial
    • Saag KG, Zanchetta JR, Devogelaer JP, Adler RA, Eastell R, See K, Krege JH, Krohn K, Warner MR 2009 Effects of teriparatide versus alendronate for treating glucocorticoid-induced osteoporosis: thirtysix- month results of a randomized, double-blind, controlled trial. Arthritis Rheum 60:3346-3355
    • (2009) Arthritis Rheum , vol.60 , pp. 3346-3355
    • Saag, K.G.1    Zanchetta, J.R.2    Devogelaer, J.P.3    Adler, R.A.4    Eastell, R.5    See, K.6    Krege, J.H.7    Krohn, K.8    Warner, M.R.9


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