Neuro-hormonal control of bone metabolism: Vasoactive intestinal peptide stimulates alkaline phosphatase activity and mRNA expression in mouse calvarial osteoblasts as well as calcium accumulation mineralized bone nodules

Regulatory Peptides

Volumn 85, Issue 1, 1999, Pages 47-58

  Lundberg, Pernilla ^a,b   Boström, Ingrid ^a   Mukohyama, Hitoshi ^a   Bjurholm, Anders ^c   Smans, Karine ^a   Lerner, Ulf H ^a  

^a UMEÅ UNIVERSITY   (Sweden)

^b NATIONAL INSTITUTE FOR WORKING LIFE   (Sweden)

^c UPPSALA UNIVERSITY HOSPITAL   (Sweden)

Author keywords

Alkaline phosphatase; Bone formation; Neuropeptides; Osteoblasts; VIP

Indexed keywords

ALKALINE PHOSPHATASE; CALCIUM; CHOLERA TOXIN; CYCLIC AMP; CYCLIC AMP PHOSPHODIESTERASE; FORSKOLIN; ISOBUTYLMETHYLXANTHINE; MESSENGER RNA; NEUROHORMONE; ROLIPRAM; VASOACTIVE INTESTINAL POLYPEPTIDE;

ANIMAL CELL; ARTICLE; BIOSYNTHESIS; BONE METABOLISM; BONE MINERAL; BONE MINERALIZATION; CALVARIA; CONTROLLED STUDY; ENZYME ACTIVITY; HORMONAL REGULATION; MOUSE; NEWBORN; NONHUMAN; NORTHERN BLOTTING; OSSIFICATION; OSTEOBLAST; PRIORITY JOURNAL;

ALKALINE PHOSPHATASE; ANIMALS; BONE AND BONES; CALCIFICATION, PHYSIOLOGIC; CALCIUM; CELLS, CULTURED; CHOLERA TOXIN; CYCLIC AMP; FORSKOLIN; GENE EXPRESSION; MICE; OSTEOBLASTS; RNA, MESSENGER; SKULL; VASOACTIVE INTESTINAL PEPTIDE;

ANIMALIA;

EID: 0033619702     PISSN: 01670115     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0167-0115(99)00069-5     Document Type: Article

References (50)

1. Quilis A.N., Gonzalez A.P. Healing in denervated bones. Acta Orthop. Scand. 45:1974;820-835.
2. Caffey J. Multiple fractures in the long bones of infants suffering from chronic subdural hematoma. Am. J. Roentgol. 56:1946;163-173.
3. Alliaume A. Fracutre des os longs dans les myélo-méningocéles. Arch. Franc. Pédiat. 7:1950;29-37.
4. Katz I.F. Spontaneous fractures in paraplegic children. J. Bone Joint Surg. 35A:1953;220-226.
5. Robin G.C. Fractures in childhood paraplegia. Paraplegia. 3:1965;165-170.
6. Jeannopoulos C.L. Bone changes in children with lesions of the spinal cord or roots. New York State J. Med. 54:1954;3219-3224.
7. Freehafer A.A., Mast W.A. Lower extremity fractures in patients with spinal-cord injury. J. Bone Joint Surg. 47:1965;683-694.
8. Hardy A.G., Dickson J.W. Pathological ossification in traumatic paraplegia. J. Bone Joint Surg. 45:1963;76-87.
9. Comarr A.E., Hutchinson R.H., Bors E. Extremity fractures of patients with spinal cord injuries. Am. J. Surg. 103:1962;732-739.
10. Eichenholtz S.N. Management of long-bone fractures in paraplegic patients. J. Bone Joint Surg. 45A:1963;299-310.
11. McMaster W.C., Stauffer E.S. The management of long bone fracture in the spinal cord injured patient. Clin. Orthop. 112:1975;44-52.
12. Smith W.S., Dunsford E.R. Healing of fractures in denervated limbs in rats. Surg. Forum. 6:1955;559-564.
13. Hulth A., Olerud S. The healing of fractures in denervated limbs. An experimental study using sensory and motor rhizotomy and peripheral deneravation. J. Trauma. 5:1965;571-579.
14. Frymoyer J.W., Malcolm H.P. Fracture healing in the sciatically denervated rat. J. Trauma. 17:1977;355-361.
15. Aro H., Eerola E., Aho A.J., Pentinnen R. Healing of experimental fractures in the denervated limbs of the rat. Clin. Orthop. Rel. Res. 155:1981;211-217.
16. Suda T.N., Udagawa N., Takahashi N. Cells of bone: osteoclast generation. Bilzikian I.P., Raisz L.G., Rodan G.A. Principles of bone biology. 1996;87-102 Academic Press, San Diego.
17. Lian J.B., Stein G. Osteoblast biology. Marcus R., Feldman D., Kelsey J. Osteoporosis. 1996;185-204 Academic Press, San Diego.
18. Lerner U.H. Kinins and neuropeptides. Bilzikian J.P., Raisz L.G., Rodan G.A. Principles of bone biology. 1996;581-596 Academic Press, San Diego.
19. Konttinen Y.T., Imai S., Suda A. Neuropeptides and the puzzel of bone remodeling. Acta Orthop. Scand. 67:(6):1996;632-639.
20. Ahmed M., Srinivasan G.R., Theodorsson E., Bjurholm A., Kreicbergs A. Extraction and quantitation of neuropeptides in bone by radioimmunoassay. A study in rat. Regul. Pept. 51:1994;179-188.
21. Hill E.L., Elde R. Effects of neonatal sympathectomy and capsaicin treatment on bone remodeling in rats. Neuroscience. 44:1994;747-755.
22. Bjurholm A., Kreicbergs A., Terenius L., Goldstein M., Schulzberg M. Neuropeptide Y, tyrosinehydroxylase-, and vasoactive intestinal polypeptide-immunoreactive nerves in bone and surrounding tissues. J. Auton. Nerve Syst. 25:1988;119-125.
23. Hill E.L., Elde R. Distribution of CGRP-, VIP-, DβH-SP-, and NPY-immunoreactive nerves in the periosteum of the rat. Cell Tissue Res. 264:1991;469-480.
24. Dohmen K., Fukushima N., Fujisaki T., Iwakiri R., Yamano Y., Nagano M., Wada K., Kodama K., Iwata K., Hachimine K., Ishibashi H. Giant metastatic VIPoma in the liver. Gastroenterol. Jpn. 26:1991;530-535.
25. Lundstedt C., Linjawi T., Amin T. Liver VIPoma: Report of two cases and literature review. Abdom. Imaging. 19:1994;433-437.
26. Grunditz T., Persson P., Håkanson R., Absood A., Böttcher G., Rerup C., Sundler P. Helodermin-like peptides in thyroid C cells. Stimulation of thyroid hormone secretion and suppression of calcium incorporation in bone. Proc. Natl. Acad. Sci. USA. 86:1989;1357-1361.
27. Hohmann E.L., Levine L., Tashjian A.H. Jr. Vasoactive intestinal peptide stimulates bone resorption via a cyclic adenosine 3′5′-monophosphate-dependent mechanism. Endocrinology. 112:1983;1233-1239.
28. Hohmann E.L., Tashjian A.H. Jr. Functional receptors for vasoactive intestinal peptide on human osteosarcoma cells. Endocrinology. 114:1984;1321-1327.
29. Bjurholm A., Kreicbergs A., Schulzberg M., Lerner U.H. Neuroendocrine regulation of cyclic AMP formation in osteoblastic cell lines (UMR-106-01 ROS 17/2.8 MC3T3-E1 and Saos-2) and primary bone cells. J. Bone Miner. Res. 7:1992;1011-1019.
30. Rahman S., Dobson P.R.M., Bunning R.A.D., Graham R., Russell G., Brown B.L. The regulation of connective tissue metabolism by vasoactive intestinal polypeptide. Regul. Pept. 37:1992;111-121.
31. Lundberg P., Bjurholm A., Lerner U.H., Ransjo M. Stimulatory and inhibitory effects of vasoactive intestinal peptide on osteoclast activity. J. Bone Miner. Res. 11:(suppl. 1):1996;M374.
32. Boonekamp P.M., Hekkelman J.W., Hamilton J.W., Cohn D.W., Jilka R.L. Effect of culture on the hormone responsiveness of bone cells isolated by an improved sequential digestion procedure. Proc. Kon. Ned. Akan. Wet. 87:1984;371-382.
33. Sambrook J., Fritsch E.F., Maniatis T. Molecular cloning: a laboratory manual. 1984;Scientific Press, Cold Spring Harbor, New York.
34. Willis J.B. Atomic absorption spectrometry. Mavrodineanu R. Analytical flame spectroscopy. 1970;525-594 Philips Technical library, Eindhoven.
35. Lerner U.H., Fredholm B.B., Ransjo M.M. Use of forskolin to study the relationship between cyclic AMP formation and bone resorption in vitro. Biochem. J. 240:1986;529-539.
36. Ransjo M., Lerner U.H. Effects of choleratoxin on cyclic AMP accumulation and bone resorption in cultured mouse calvaria. Biochem. Biophys. Acta. 930:1986;378-391.
37. Said S.I. Vasoactive intestinal polypeptide Biological role in health and disease Trends. Endocrinol. Metab. 2:1991;107-112.
38. Stein G.S., Lian J.B. Molecular mechanisms mediating proliferation/differentiation interrelationships during progressive development of the osteoblast phenotype. Endocrine Rev. 14:1993;424-442.
39. Lerner U.H., Ransjö M., Fredholm B.B. Comparative study of the effects of cyclic nucleotide phosphodiesterase inhibitors on bone resorption and cyclic AMP formation in vitro. Biochem. Pharmacol. 23:1986;4177-4189.
40. Seamon K.B., Daly J.W. Forskolin: a unique diterpene activator of cyclic AMP-generating systems. J. Cyclic Nucl. Res. 7:1981;201-224.
41. Middlebrook IL, Dorland RB. Bacterial toxins: cellular mechanisms of action. Microbiol. Rev. 1984;199-221.
42. Yee J.A. Stimulation of alkaline phosphatase activity in cultured neonatal mouse calvarial bone cells by parathyroid hormone. Calcif. Tissue Int. 37:1985;530-538.
43. Nakatani Y., Tsuni M., Hakeda Y., Kurihara N., Fujita K., Kumegava M. Effects of parathyroid hormone on cAMP production and alkaline phosphatase activity in osteoblastic clone MC3T3-El cells. Effects of parathyroid hormone on cAMP production and alkaline phosphatase activity in osteoblastic clone MC3 T3 -El cells. Biochem. Biophys. Res. Commun. 123:1984;894-898.
44. 2 in growing rats: Increased metaphyseal hard tissue and cortico-endostal bone formation. Calcif. Tissue Int. 37:1985;148-157.
45. 2. Endocrinology. 130:1992;443-448.
46. Whyte M.P. Hypophosphatasia and the role of alkaline phosphatase in skeletal mineralization. Endocrine Rev. 15:1994;439-461.
47. Bhargava U. Ultrastructural analysis of bone nodules formed in vitro by isolated fetal rat calvaria cells. Bone. 9:1988;155-163.
48. Bellows C.G., Aubin J.E., Heersche J.N.M., Antosz M.E. Mineralized bone nodules formed in vitro from enzymatically released rat calvaria cell populations. Calcif. Tissue Int. 38:1986;143-154.
49. Bellows C.G., Aubin J.E., Heersche J.N.M. Initiation and progression of mineralization of bone nodules formed in vitro: the role of alkaline phosphatase and organic phosphate. J. Bone Miner. Res. 14:1991;27-40.
50. Aubin J.E., Liu F., Maval L., Gupta A.K. Osteoblast and chondroblast differentiation. Bone. 17:1995;77-83.