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Volumn 9, Issue 15, 2008, Pages 2717-2726

Could rusalatide acetate be the future drug of choice for diabetic foot ulcers and fracture repair?

Author keywords

Angiogenesis; Chronic wounds; Diabetic foot ulcers; Endothelial dysfunction; Fracture repair; Osteoporosis; Rusalatide acetate

Indexed keywords

ADENOSINE RECEPTOR STIMULATING AGENT; ANGIOGENESIS MODULATOR; ANGIOTENSIN DERIVATIVE; ATORVASTATIN; BECAPLERMIN; CHRYSALIN; DSC 127; GAM 501; NITRIC OXIDE; PARATHYROID HORMONE[1-31][27 LEUCINE] AMIDE 22,26 AMIDE; PLACEBO; PLATELET DERIVED GROWTH FACTOR; RECOMBINANT BONE MORPHOGENETIC PROTEIN 2; RECOMBINANT LACTOFERRIN; RECOMBINANT OSTEOGENIC PROTEIN 1; RECOMBINANT PLATELET DERIVED GROWTH FACTOR; RECOMBINANT PROTEIN; RECOMBINANT VASCULOTROPIN; TELBERMIN; TP 508; UNCLASSIFIED DRUG;

EID: 55249122720     PISSN: 14656566     EISSN: None     Source Type: Journal    
DOI: 10.1517/14656566.9.15.2717     Document Type: Article
Times cited : (14)

References (77)
  • 1
    • 0031708405 scopus 로고    scopus 로고
    • The future of recombinant growth factors in wound healing
    • Robson MC, Mustoe TA, Hunt TK. The future of recombinant growth factors in wound healing. Am J Surg 1998;176:80S-82S
    • (1998) Am J Surg , vol.176
    • Robson, M.C.1    Mustoe, T.A.2    Hunt, T.K.3
  • 2
    • 0023675385 scopus 로고
    • Growth factors and their role in wound and fracture healing
    • Nemeth GG, Bolander ME, Martin GR. Growth factors and their role in wound and fracture healing. Prog Clin Biol Res 1988;266:1-17
    • (1988) Prog Clin Biol Res , vol.266 , pp. 1-17
    • Nemeth, G.G.1    Bolander, M.E.2    Martin, G.R.3
  • 3
    • 33846434456 scopus 로고    scopus 로고
    • Thrombin peptide Chrysalinö stimulates healing of diabetic foot ulcers in a placebo-controlled phase I/II study
    • Fife C, Mader JT, Stone J, et al. Thrombin peptide Chrysalinö stimulates healing of diabetic foot ulcers in a placebo-controlled phase I/II study. Wound Repair Regen 2007;15:23-34
    • (2007) Wound Repair Regen , vol.15 , pp. 23-34
    • Fife, C.1    Mader, J.T.2    Stone, J.3
  • 4
    • 33750695006 scopus 로고    scopus 로고
    • Thrombin peptide TP508 stimulates cellular events leading to angiogenesis, revascularization, and repair of dermal and musculoskeletal tissues
    • Ryaby JT, Sheller MR, Levine BP, et al. Thrombin peptide TP508 stimulates cellular events leading to angiogenesis, revascularization, and repair of dermal and musculoskeletal tissues. J Bone Joint Surg Am 2006;88(Suppl 3):132-9
    • (2006) J Bone Joint Surg Am , vol.88 , Issue.SUPPL. 3 , pp. 132-139
    • Ryaby, J.T.1    Sheller, M.R.2    Levine, B.P.3
  • 5
    • 55249108048 scopus 로고    scopus 로고
    • Phase 3 acceleration of distal radius fracture healing with a thrombin receptor binding peptide
    • Available from:, Accessed 14 May 2008
    • Ladd AL, Shin AYS, Bramler DG, et al. Phase 3 acceleration of distal radius fracture healing with a thrombin receptor binding peptide. OrthoLogic Web Site 2007. Available from: http://www.orthologic.com/ research-development/chrysalinTP508.php [Accessed 14 May 2008]
    • (2007) OrthoLogic Web Site
    • Ladd, A.L.1    Shin, A.Y.S.2    Bramler, D.G.3
  • 6
    • 55249098891 scopus 로고    scopus 로고
    • Thrombin and thrombin peptides in wound healing and tissue repair
    • Tsopanoglou N, Maragoudakis M, editors, Springer, New York;
    • Olszewska-Pazdrak B, Bergmann JS, Fuller GM, et al. Thrombin and thrombin peptides in wound healing and tissue repair. In: Tsopanoglou N, Maragoudakis M, editors, Thrombin: health and diseases. Springer, New York; 2008
    • (2008) Thrombin: Health and diseases
    • Olszewska-Pazdrak, B.1    Bergmann, J.S.2    Fuller, G.M.3
  • 7
    • 0037218315 scopus 로고    scopus 로고
    • Wound healing and diabetes mellitus
    • Greenhalgh DG. Wound healing and diabetes mellitus. Clin Plast Surg 2003;30:37-45
    • (2003) Clin Plast Surg , vol.30 , pp. 37-45
    • Greenhalgh, D.G.1
  • 8
    • 26244447516 scopus 로고    scopus 로고
    • The comprehensive therapy of diabetic foot ulcers
    • Millington JT, Ellenzweig J. The comprehensive therapy of diabetic foot ulcers. Compr Ther 2005;31:50-8
    • (2005) Compr Ther , vol.31 , pp. 50-58
    • Millington, J.T.1    Ellenzweig, J.2
  • 9
  • 10
    • 27744448125 scopus 로고    scopus 로고
    • Wound healing and its impairment in the diabetic foot
    • Falanga V. Wound healing and its impairment in the diabetic foot. Lancet 2005;366:1736-43
    • (2005) Lancet , vol.366 , pp. 1736-1743
    • Falanga, V.1
  • 11
    • 0031923954 scopus 로고    scopus 로고
    • Skin substitutes to enhance wound healing
    • Mansbridge J. Skin substitutes to enhance wound healing. Expert Opin Investig Drugs 1998;7:803-9
    • (1998) Expert Opin Investig Drugs , vol.7 , pp. 803-809
    • Mansbridge, J.1
  • 12
    • 16244380810 scopus 로고    scopus 로고
    • A controlled study of the use of autologous platelet gel for the treatment of diabetic foot ulcers
    • Saldalamacchia G, Lapice E, Cuomo V, et al. A controlled study of the use of autologous platelet gel for the treatment of diabetic foot ulcers. Nutr Metab Cardiovasc Dis 2004;14:395-6
    • (2004) Nutr Metab Cardiovasc Dis , vol.14 , pp. 395-396
    • Saldalamacchia, G.1    Lapice, E.2    Cuomo, V.3
  • 13
    • 33745513688 scopus 로고    scopus 로고
    • Clinical evaluation of recombinant human platelet-derived growth factor for the treatment of lower extremity ulcers
    • discussion 150S-151S
    • Steed DL. Clinical evaluation of recombinant human platelet-derived growth factor for the treatment of lower extremity ulcers. Plast Reconstr Surg 2006;117:l43S-149S; discussion 150S-151S
    • (2006) Plast Reconstr Surg , vol.117
    • Steed, D.L.1
  • 14
    • 0035989750 scopus 로고    scopus 로고
    • Becaplermin: Recombinant platelet derived growth factor, a new treatment for healing diabetic foot ulcers
    • Nagai MK, Embil JM. Becaplermin: recombinant platelet derived growth factor, a new treatment for healing diabetic foot ulcers. Expert Opin Biol Ther 2002;2:211-8
    • (2002) Expert Opin Biol Ther , vol.2 , pp. 211-218
    • Nagai, M.K.1    Embil, J.M.2
  • 15
    • 34848839211 scopus 로고    scopus 로고
    • Prevalence of long-bone non-unions
    • Tzioupis C, Giannoudis PV. Prevalence of long-bone non-unions. Injury 2007;38(Suppl 2):S3-9
    • (2007) Injury , vol.38 , Issue.SUPPL. 2
    • Tzioupis, C.1    Giannoudis, P.V.2
  • 17
    • 27744503046 scopus 로고    scopus 로고
    • Clinical applications of BMP-7: The UK perspective
    • Giannoudis PV, Tzioupis C. Clinical applications of BMP-7: the UK perspective. Injury 2005;36(Suppl 3):S47-50
    • (2005) Injury , vol.36 , Issue.SUPPL. 3
    • Giannoudis, P.V.1    Tzioupis, C.2
  • 18
    • 35748948100 scopus 로고    scopus 로고
    • Bone morphogenic protein and its application in trauma cases: A current concept update
    • Vaibhav B, Nilesh P, Vikram S, et al. Bone morphogenic protein and its application in trauma cases: a current concept update. Injury 2007;38:1227-35
    • (2007) Injury , vol.38 , pp. 1227-1235
    • Vaibhav, B.1    Nilesh, P.2    Vikram, S.3
  • 19
    • 34548364248 scopus 로고    scopus 로고
    • Using angiogenesis in chronic wound care with becaplermin and oxidized regenerated cellulose/collagen
    • Hollister C, Li VW. Using angiogenesis in chronic wound care with becaplermin and oxidized regenerated cellulose/collagen. Nurs Clin North Am 2007;42:457-65
    • (2007) Nurs Clin North Am , vol.42 , pp. 457-465
    • Hollister, C.1    Li, V.W.2
  • 20
    • 0035092184 scopus 로고    scopus 로고
    • Effectiveness of platelet releasate for the treatment of diabetic neuropathic foot ulcers
    • Margolis DJ, Kantor J, Santanna J, et al. Effectiveness of platelet releasate for the treatment of diabetic neuropathic foot ulcers. Diabetes Care 2001;24:483-8
    • (2001) Diabetes Care , vol.24 , pp. 483-488
    • Margolis, D.J.1    Kantor, J.2    Santanna, J.3
  • 21
    • 33846638398 scopus 로고    scopus 로고
    • Stem cells in cutaneous wound healing
    • Cha J, Falanga V. Stem cells in cutaneous wound healing. Clin Dermatol 2007;25:73-8
    • (2007) Clin Dermatol , vol.25 , pp. 73-78
    • Cha, J.1    Falanga, V.2
  • 22
    • 55249107835 scopus 로고    scopus 로고
    • Available from:, Accessed 24 August 2008
    • World Health Organization. 2008. Available from: http://www.who.int/ diabetes/facts/world_figures/en/ [Accessed 24 August 2008]
    • (2008)
  • 24
    • 55249086537 scopus 로고    scopus 로고
    • Consensus Development Conference on Diabetic Foot Wound Care. Adv Wound Care 1999;12:353-61
    • Consensus Development Conference on Diabetic Foot Wound Care. Adv Wound Care 1999;12:353-61
  • 26
    • 0041308236 scopus 로고    scopus 로고
    • Amputation and mortality in new-onset diabetic foot ulcers stratified by etiology
    • Moulik PK, Mtonga R, Gill GV. Amputation and mortality in new-onset diabetic foot ulcers stratified by etiology. Diabetes Care 2003;26:491-4
    • (2003) Diabetes Care , vol.26 , pp. 491-494
    • Moulik, P.K.1    Mtonga, R.2    Gill, G.V.3
  • 27
    • 0036814116 scopus 로고    scopus 로고
    • Cost-effective management of recalcitrant diabetic foot ulcers
    • Albert S. Cost-effective management of recalcitrant diabetic foot ulcers. Clin Podiatr Med Surg 2002;19:483-91
    • (2002) Clin Podiatr Med Surg , vol.19 , pp. 483-491
    • Albert, S.1
  • 28
    • 0030018167 scopus 로고    scopus 로고
    • Effect of extensive debridement and treatment on the healing of diabetic foot ulcers. Diabetic Ulcer Study Group
    • Steed DL, Donohoe D, Webster MW, et al. Effect of extensive debridement and treatment on the healing of diabetic foot ulcers. Diabetic Ulcer Study Group. J Am Coll Surg 1996;183:61-4
    • (1996) J Am Coll Surg , vol.183 , pp. 61-64
    • Steed, D.L.1    Donohoe, D.2    Webster, M.W.3
  • 29
    • 0031734833 scopus 로고    scopus 로고
    • Efficacy and safety of a topical gel formulation of recombinant human platelet-derived growth factor-BB (becaplermin) in patients with chronic neuropathic diabetic ulcers. A phase III randomized placebo-controlled double-blind study
    • Wieman TJ, Smiell JM, Su Y. Efficacy and safety of a topical gel formulation of recombinant human platelet-derived growth factor-BB (becaplermin) in patients with chronic neuropathic diabetic ulcers. A phase III randomized placebo-controlled double-blind study. Diabetes Care 1998;21:822-7
    • (1998) Diabetes Care , vol.21 , pp. 822-827
    • Wieman, T.J.1    Smiell, J.M.2    Su, Y.3
  • 30
    • 0032720053 scopus 로고    scopus 로고
    • Efficacy and safety of becaplermin (recombinant human platelet-derived growth factor-BB) in patients with nonhealing, lower extremity diabetic ulcers: A combined analysis of four randomized studies
    • Smiell JM, Wieman TJ, Steed DL, et al. Efficacy and safety of becaplermin (recombinant human platelet-derived growth factor-BB) in patients with nonhealing, lower extremity diabetic ulcers: a combined analysis of four randomized studies. Wound Repair Regen 1999;7:335-46
    • (1999) Wound Repair Regen , vol.7 , pp. 335-346
    • Smiell, J.M.1    Wieman, T.J.2    Steed, D.L.3
  • 31
    • 0027243289 scopus 로고
    • The rationale for precise management of distal radius fractures
    • Ark J, Jupiter JB. The rationale for precise management of distal radius fractures. Orthop Clin North Am 1993;24:205-10
    • (1993) Orthop Clin North Am , vol.24 , pp. 205-210
    • Ark, J.1    Jupiter, J.B.2
  • 32
    • 0033001999 scopus 로고    scopus 로고
    • Strong bones in later life: Luxury or necessity?
    • Delmas PD, Fraser M. Strong bones in later life: luxury or necessity? Bull World Health Organ 1999;77:416-22
    • (1999) Bull World Health Organ , vol.77 , pp. 416-422
    • Delmas, P.D.1    Fraser, M.2
  • 33
    • 33750209491 scopus 로고    scopus 로고
    • An estimate of the worldwide prevalence and disability associated with osteoporotic fractures
    • Johnell O, Kanis JA. An estimate of the worldwide prevalence and disability associated with osteoporotic fractures. Osteoporos Int 2006;17:1726-33
    • (2006) Osteoporos Int , vol.17 , pp. 1726-1733
    • Johnell, O.1    Kanis, J.A.2
  • 34
    • 0030964587 scopus 로고    scopus 로고
    • The socioeconomic burden of fractures: Today and in the 21st century
    • discussion 25S-26S
    • Johnell O. The socioeconomic burden of fractures: today and in the 21st century. Am J Med 1997;103:20S-25S; discussion 25S-26S
    • (1997) Am J Med , vol.103
    • Johnell, O.1
  • 35
    • 0037129560 scopus 로고    scopus 로고
    • Epidemiology and outcomes of osteoporotic fractures
    • Cummings SR, Melton LJ. Epidemiology and outcomes of osteoporotic fractures. Lancet 2002;359:1761-7
    • (2002) Lancet , vol.359 , pp. 1761-1767
    • Cummings, S.R.1    Melton, L.J.2
  • 36
    • 85045483986 scopus 로고    scopus 로고
    • Clinical effectiveness and cost-effectiveness of bone morphogenetic proteins in the non-healing of fractures and spinal fusion: A systematic review
    • Garrison KR, Donell S, Ryder J, et al. Clinical effectiveness and cost-effectiveness of bone morphogenetic proteins in the non-healing of fractures and spinal fusion: a systematic review: Health Technol Assess 2007;11:1-150
    • (2007) Health Technol Assess , vol.11 , pp. 1-150
    • Garrison, K.R.1    Donell, S.2    Ryder, J.3
  • 37
    • 33847303506 scopus 로고    scopus 로고
    • Health economics: A cost analysis of treatment of persistent fracture non-unions using bone morphogenetic protein-7
    • Dahabreh Z, Dimitriou R, Giannoudis PV. Health economics: a cost analysis of treatment of persistent fracture non-unions using bone morphogenetic protein-7. Injury 2007;38:371-7
    • (2007) Injury , vol.38 , pp. 371-377
    • Dahabreh, Z.1    Dimitriou, R.2    Giannoudis, P.V.3
  • 38
    • 33947311076 scopus 로고    scopus 로고
    • Can we accelerate fracture healing? A critical analysis of the literature
    • Giannoudis P, Psarakis S, Kontakis G. Can we accelerate fracture healing? A critical analysis of the literature. Injury 2007;38(Suppl 1):S81-9
    • (2007) Injury , vol.38 , Issue.SUPPL. 1
    • Giannoudis, P.1    Psarakis, S.2    Kontakis, G.3
  • 39
    • 38049117881 scopus 로고    scopus 로고
    • Evidence supporting the use of bone morphogenetic proteins for spinal fusion surgery
    • Robinson Y, Heyde CE, Tschoke SK, et al. Evidence supporting the use of bone morphogenetic proteins for spinal fusion surgery. Expert Rev Med Devices 2008;5:75-84
    • (2008) Expert Rev Med Devices , vol.5 , pp. 75-84
    • Robinson, Y.1    Heyde, C.E.2    Tschoke, S.K.3
  • 40
    • 0024104359 scopus 로고
    • Synthetic peptides bind to high-affinity thrombin receptors and modulate thrombin mitogenesis
    • Glenn KC, Frost GH, Bergmann JS, et al. Synthetic peptides bind to high-affinity thrombin receptors and modulate thrombin mitogenesis. Peptide Res 1988;1:65-73
    • (1988) Peptide Res , vol.1 , pp. 65-73
    • Glenn, K.C.1    Frost, G.H.2    Bergmann, J.S.3
  • 41
    • 0027279724 scopus 로고
    • The role of thrombin and thrombin receptor activating peptide (TRAP-508) in initiation of tissue repair
    • Stiernberg J, Redin WR, Warner WS, et al. The role of thrombin and thrombin receptor activating peptide (TRAP-508) in initiation of tissue repair. Thromb Haemostasis 1993;70:158-62
    • (1993) Thromb Haemostasis , vol.70 , pp. 158-162
    • Stiernberg, J.1    Redin, W.R.2    Warner, W.S.3
  • 42
    • 18244410123 scopus 로고    scopus 로고
    • Thrombin peptide (TP508) promotes fracture repair by up-regulating inflammatory mediators, early growth factors, and increasing angiogenesis
    • Wang H, Li X, Tomin E, et al. Thrombin peptide (TP508) promotes fracture repair by up-regulating inflammatory mediators, early growth factors, and increasing angiogenesis. J Orthop Res 2005;23:671-9
    • (2005) J Orthop Res , vol.23 , pp. 671-679
    • Wang, H.1    Li, X.2    Tomin, E.3
  • 43
    • 35348940696 scopus 로고    scopus 로고
    • TP508 accelerates fracture repair by promoting cell growth over cell death
    • Li X, Wang H, Touma E, et al. TP508 accelerates fracture repair by promoting cell growth over cell death. Biochem Biophys Res Commun 2007;364:187-93
    • (2007) Biochem Biophys Res Commun , vol.364 , pp. 187-193
    • Li, X.1    Wang, H.2    Touma, E.3
  • 44
    • 55249109790 scopus 로고    scopus 로고
    • Olszewska-Pazdrak B, Hart Van-Tassel A, Carney DH. Thrombin peptide TP508 upregulates expression and activation of eNOS and prevent hypoxia-induced eNOS downregulation in human endothelia] cells. Mol Biol Cell 2006;17(Suppl):A2654
    • Olszewska-Pazdrak B, Hart Van-Tassel A, Carney DH. Thrombin peptide TP508 upregulates expression and activation of eNOS and prevent hypoxia-induced eNOS downregulation in human endothelia] cells. Mol Biol Cell 2006;17(Suppl):A2654
  • 45
    • 55249095087 scopus 로고    scopus 로고
    • Effects of thrombin peptide TP508 on cultured endothelial cells suggest a wound healing mode of action that involves reversal of endothelial dysfunction
    • Olszewska-Pazdrak B, Hein T, Carney DH. Effects of thrombin peptide TP508 on cultured endothelial cells suggest a wound healing mode of action that involves reversal of endothelial dysfunction. Wound Repair Regen 2007;15:A32
    • (2007) Wound Repair Regen , vol.15
    • Olszewska-Pazdrak, B.1    Hein, T.2    Carney, D.H.3
  • 46
    • 49749097210 scopus 로고    scopus 로고
    • Thrombin peptide TP508 prevents endothelial dysfunction and restores myocardial function in hearts with chronic ischemia
    • Fossum TW, Olszewska-Pazdrak B, Mertens MM, et al. Thrombin peptide TP508 prevents endothelial dysfunction and restores myocardial function in hearts with chronic ischemia. J Cardiovasc Pharmacol Ther 2008;13:214-25
    • (2008) J Cardiovasc Pharmacol Ther , vol.13 , pp. 214-225
    • Fossum, T.W.1    Olszewska-Pazdrak, B.2    Mertens, M.M.3
  • 47
    • 24644500665 scopus 로고    scopus 로고
    • Effects of L-arginine on fibroblast growth factor 2-induced angiogenesis in a model of endothelial dysfunction
    • Voisine P, Li J, Bianchi C, et al. Effects of L-arginine on fibroblast growth factor 2-induced angiogenesis in a model of endothelial dysfunction. Circulation 2005;112:1202-7
    • (2005) Circulation , vol.112 , pp. 1202-1207
    • Voisine, P.1    Li, J.2    Bianchi, C.3
  • 48
    • 0032512822 scopus 로고    scopus 로고
    • Nitric oxide is an upstream signal of vascular endothelial growth factor-induced extracellular signal-regulated kinase1/2 activation in postcapillary endothelium
    • Parenti A, Morbidelli L, Cui XL, et al. Nitric oxide is an upstream signal of vascular endothelial growth factor-induced extracellular signal-regulated kinase1/2 activation in postcapillary endothelium. J Biol Chem 1998;273:4220-6
    • (1998) J Biol Chem , vol.273 , pp. 4220-4226
    • Parenti, A.1    Morbidelli, L.2    Cui, X.L.3
  • 49
    • 0034698284 scopus 로고    scopus 로고
    • Phosphorylation of the endothelial nitric oxide synthase at ser-1177 is required for VEGF-induced endothelial cell migration
    • Dimmeler S, Dernbach E, Zeiher AM. Phosphorylation of the endothelial nitric oxide synthase at ser-1177 is required for VEGF-induced endothelial cell migration. FEBS Lett 2000;477:258-62
    • (2000) FEBS Lett , vol.477 , pp. 258-262
    • Dimmeler, S.1    Dernbach, E.2    Zeiher, A.M.3
  • 50
    • 34248213008 scopus 로고    scopus 로고
    • Diabetic impairments in NO-mediated endothelial progenitor cell mobilization and homing are reversed by hyperoxia and SDF-1 alpha
    • Gallagher KA, Liu ZJ, Xiao M, et al. Diabetic impairments in NO-mediated endothelial progenitor cell mobilization and homing are reversed by hyperoxia and SDF-1 alpha. J Clin Invest 2007;117:1249-59
    • (2007) J Clin Invest , vol.117 , pp. 1249-1259
    • Gallagher, K.A.1    Liu, Z.J.2    Xiao, M.3
  • 51
    • 34248225758 scopus 로고    scopus 로고
    • Cellular and molecular basis of wound healing in diabetes
    • Brem H, Tomic-Canic M. Cellular and molecular basis of wound healing in diabetes. J Clin Invest 2007;117:1219-22
    • (2007) J Clin Invest , vol.117 , pp. 1219-1222
    • Brem, H.1    Tomic-Canic, M.2
  • 52
    • 34247552262 scopus 로고    scopus 로고
    • Nitric oxide donors selectively reduce the expression of matrix metalloproteinases-8 and -9 by human diabetic skin fibroblasts
    • Burrow JW, Koch JA, Chuang HH, et al. Nitric oxide donors selectively reduce the expression of matrix metalloproteinases-8 and -9 by human diabetic skin fibroblasts. J Surg Res 2007;140:90-8
    • (2007) J Surg Res , vol.140 , pp. 90-98
    • Burrow, J.W.1    Koch, J.A.2    Chuang, H.H.3
  • 53
    • 0026716614 scopus 로고
    • Enhancement of incisional wound healing and neovascularization in normal rats by thrombin and synthetic thrombin receptor-activating peptides
    • Carney DH, Mann R, Redin WR, et al. Enhancement of incisional wound healing and neovascularization in normal rats by thrombin and synthetic thrombin receptor-activating peptides. J Clin Invest 1992;89:1469-77
    • (1992) J Clin Invest , vol.89 , pp. 1469-1477
    • Carney, D.H.1    Mann, R.2    Redin, W.R.3
  • 54
    • 0033918177 scopus 로고    scopus 로고
    • Acceleration of full-thickness wound healing in normal rats by the synthetic thrombin peptide, TP508
    • Stiernberg J, Norfleet AM, Redin WR, et al. Acceleration of full-thickness wound healing in normal rats by the synthetic thrombin peptide, TP508. Wound Repair Regen 2000;8:204-15
    • (2000) Wound Repair Regen , vol.8 , pp. 204-215
    • Stiernberg, J.1    Norfleet, A.M.2    Redin, W.R.3
  • 55
    • 0034581330 scopus 로고    scopus 로고
    • Thrombin peptide, TP508, stimulates angiogenic responses in animal models of dermal wound healing, in chick chorioallantoic membranes, and in cultured human aortic and microvascular endothelial cells
    • Norfleet AM, Bergmann JS, Carney DH. Thrombin peptide, TP508, stimulates angiogenic responses in animal models of dermal wound healing, in chick chorioallantoic membranes, and in cultured human aortic and microvascular endothelial cells. Gen Pharmacol 2000;35:249-54
    • (2000) Gen Pharmacol , vol.35 , pp. 249-254
    • Norfleet, A.M.1    Bergmann, J.S.2    Carney, D.H.3
  • 57
    • 0037901867 scopus 로고    scopus 로고
    • Hampton S. The complexities of heel ulcers. Nurs Stand 2003;17:68-70, 72, 74
    • Hampton S. The complexities of heel ulcers. Nurs Stand 2003;17:68-70, 72, 74
  • 58
    • 3442894442 scopus 로고    scopus 로고
    • Diabetic heel ulcers: A major risk factor for lower extremity amputation
    • Younes NA, Albsoul AM, Awad H. Diabetic heel ulcers: a major risk factor for lower extremity amputation. Ostomy Wound Manage 2004;50:50-60
    • (2004) Ostomy Wound Manage , vol.50 , pp. 50-60
    • Younes, N.A.1    Albsoul, A.M.2    Awad, H.3
  • 59
    • 0031939017 scopus 로고    scopus 로고
    • Endothelial dysfunction and the expression of endothelial nitric oxide synthetase in diabetic neuropathy, vascular disease, and foot ulceration
    • Veves A, Akbari CM, Primavera J, et al. Endothelial dysfunction and the expression of endothelial nitric oxide synthetase in diabetic neuropathy, vascular disease, and foot ulceration. Diabetes 1998;47:457-63
    • (1998) Diabetes , vol.47 , pp. 457-463
    • Veves, A.1    Akbari, C.M.2    Primavera, J.3
  • 60
    • 0034219776 scopus 로고    scopus 로고
    • The nitric oxide connection: Hyperbaric oxygen therapy, becaplermin, and diabetic ulcer management
    • Boykin JV Jr. The nitric oxide connection: hyperbaric oxygen therapy, becaplermin, and diabetic ulcer management. Adv Skin Wound Care 2000;13:169-74
    • (2000) Adv Skin Wound Care , vol.13 , pp. 169-174
    • Boykin Jr., J.V.1
  • 61
    • 0036020282 scopus 로고    scopus 로고
    • Expression of matrix-metalloproteinases and their inhibitors in the wounds of diabetic and non-diabetic patients
    • Lobmann R, Ambrosch A, Schultz G, et al. Expression of matrix-metalloproteinases and their inhibitors in the wounds of diabetic and non-diabetic patients. Diabetologia 2002;45:1011-6
    • (2002) Diabetologia , vol.45 , pp. 1011-1016
    • Lobmann, R.1    Ambrosch, A.2    Schultz, G.3
  • 62
    • 0036425577 scopus 로고    scopus 로고
    • Effects of nitric oxide releasing poly(vinyl alcohol) hydrogel dressings on dermal wound healing in diabetic mice
    • Masters KS, Leibovich SJ, Belem P, et al. Effects of nitric oxide releasing poly(vinyl alcohol) hydrogel dressings on dermal wound healing in diabetic mice. Wound Repair Regen 2002;10:286-94
    • (2002) Wound Repair Regen , vol.10 , pp. 286-294
    • Masters, K.S.1    Leibovich, S.J.2    Belem, P.3
  • 64
    • 0033953208 scopus 로고    scopus 로고
    • Nitric oxide modulates fracture healing
    • Diwan AD, Wang MX, Jang D, et al. Nitric oxide modulates fracture healing. J Bone Miner Res 2000;15:342-51
    • (2000) J Bone Miner Res , vol.15 , pp. 342-351
    • Diwan, A.D.1    Wang, M.X.2    Jang, D.3
  • 65
    • 0033931550 scopus 로고    scopus 로고
    • Nitric oxide regulates alkaline phosphatase activity in rat fracture callus explant cultures
    • Namkung-Matthai H, Diwan A, Mason RS, et al. Nitric oxide regulates alkaline phosphatase activity in rat fracture callus explant cultures. Redox Rep 2000;5:126-7
    • (2000) Redox Rep , vol.5 , pp. 126-127
    • Namkung-Matthai, H.1    Diwan, A.2    Mason, R.S.3
  • 67
    • 5644235491 scopus 로고    scopus 로고
    • Forearm endothelial function and bone mineral loss in postmenopausal women
    • Sanada M, Taguchi A, Higashi Y, et al. Forearm endothelial function and bone mineral loss in postmenopausal women. Atherosclerosis 2004;176:387-92
    • (2004) Atherosclerosis , vol.176 , pp. 387-392
    • Sanada, M.1    Taguchi, A.2    Higashi, Y.3
  • 68
    • 55249099351 scopus 로고    scopus 로고
    • Genentech. Genentech Announces full year and fourth quarter 2007 results 14 Jan 2008 (See Clinical Developments): Financial Press Releases 2008. Available from: http://www.gene.com/gene/news/press-releases/ [Accessed 24 August 2008]
    • Genentech. Genentech Announces full year and fourth quarter 2007 results 14 Jan 2008 (See Clinical Developments): Financial Press Releases 2008. Available from: http://www.gene.com/gene/news/press-releases/ [Accessed 24 August 2008]
  • 69
    • 55249096724 scopus 로고    scopus 로고
    • Trials.gov, C. Safety and efficacy study of MRE0094 to treat large, single or multiple, chronic neuropathic diabetic foot ulcers. 9 June 2008. Available from: http://clinicaltrials.gov/ct2/show/ ?term=MRE0094&rank=1 [Accessed 24 August 2008]
    • Trials.gov, C. Safety and efficacy study of MRE0094 to treat large, single or multiple, chronic neuropathic diabetic foot ulcers. 9 June 2008. Available from: http://clinicaltrials.gov/ct2/show/ ?term=MRE0094&rank=1 [Accessed 24 August 2008]
  • 70
    • 35448947523 scopus 로고    scopus 로고
    • Statins may be useful in diabetic foot ulceration treatment and prevention
    • Gulcan E, Gulcan A, Erbilen E, et al. Statins may be useful in diabetic foot ulceration treatment and prevention. Med Hypotheses 2007;69:1313-5
    • (2007) Med Hypotheses , vol.69 , pp. 1313-1315
    • Gulcan, E.1    Gulcan, A.2    Erbilen, E.3
  • 71
    • 7544251097 scopus 로고    scopus 로고
    • Are cardiovascular disease and osteoporosis directly linked?
    • Whitney C, Warburton DE, Frohlich J, et al. Are cardiovascular disease and osteoporosis directly linked? Sports Med 2004;34:779-807
    • (2004) Sports Med , vol.34 , pp. 779-807
    • Whitney, C.1    Warburton, D.E.2    Frohlich, J.3
  • 72
    • 13844313786 scopus 로고    scopus 로고
    • Healing of diabetic foot ulcers in L-arginine-treated patients
    • Arana V, Paz Y, Gonzalez A, et al. Healing of diabetic foot ulcers in L-arginine-treated patients. Biomed Pharmacother 2004;58:588-97
    • (2004) Biomed Pharmacother , vol.58 , pp. 588-597
    • Arana, V.1    Paz, Y.2    Gonzalez, A.3
  • 73
    • 55249103884 scopus 로고    scopus 로고
    • FDA Announces new labeling changes for regranex
    • Available from:, Accessed 13 June
    • FDA Announces new labeling changes for regranex. FDA News 2008. Available from: http://www.fda.gov/bbs/topics/NEWS/2008/NEW01845.html [Accessed 13 June 2008]
    • (2008) FDA News
  • 74
    • 33745817069 scopus 로고    scopus 로고
    • Antitumor activity of JS-K [O2-(2,4-dinitrophenyl) 1-[(4-ethoxycarbonyl) piperazin-1-yl]diazen-1-ium-1,2-diolate] and related O2-aryl diazeniumdiolates in vitro and in vivo
    • Shami PJ, Saavedra JE, Bonifant CL, et al. Antitumor activity of JS-K [O2-(2,4-dinitrophenyl) 1-[(4-ethoxycarbonyl) piperazin-1-yl]diazen-1-ium-1,2-diolate] and related O2-aryl diazeniumdiolates in vitro and in vivo. J Med Chem 2006;49:4356-66
    • (2006) J Med Chem , vol.49 , pp. 4356-4366
    • Shami, P.J.1    Saavedra, J.E.2    Bonifant, C.L.3
  • 75
    • 0036753643 scopus 로고    scopus 로고
    • Atherosclerosis and cancer: Common pathways on the vascular endothelium
    • Morganti M, Carpi A, Nicolini A, et al. Atherosclerosis and cancer: common pathways on the vascular endothelium. Biomed Pharmacother 2002;56:317-24
    • (2002) Biomed Pharmacother , vol.56 , pp. 317-324
    • Morganti, M.1    Carpi, A.2    Nicolini, A.3
  • 76
    • 4344576220 scopus 로고    scopus 로고
    • Repair of rabbit segmental defects with the thrombin peptide, TP508
    • Sheller MR, Crowther RS, Kinney JH, et al. Repair of rabbit segmental defects with the thrombin peptide, TP508. J Orthop Res 2004;22:1094-9
    • (2004) J Orthop Res , vol.22 , pp. 1094-1099
    • Sheller, M.R.1    Crowther, R.S.2    Kinney, J.H.3
  • 77
    • 14644444227 scopus 로고    scopus 로고
    • Effect of varied release kinetics of the osteogenic thrombin pepride TP508 from biodegradable, polymeric scaffolds on bone formation in vivo
    • Hedberg EL, Kroese-Deutman HC, Shih CK, et al. Effect of varied release kinetics of the osteogenic thrombin pepride TP508 from biodegradable, polymeric scaffolds on bone formation in vivo. J Biomed Mater Res A 2005;72:343-53
    • (2005) J Biomed Mater Res A , vol.72 , pp. 343-353
    • Hedberg, E.L.1    Kroese-Deutman, H.C.2    Shih, C.K.3


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