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Volumn 45, Issue 2, 2009, Pages 309-320

Substance P stimulates bone marrow stromal cell osteogenic activity, osteoclast differentiation, and resorption activity in vitro

Author keywords

Bone marrow stromal cell; Mouse; Neuropeptide; Osteoblast; Osteoclasts; Osteogenesis; Substance P

Indexed keywords

ACID PHOSPHATASE TARTRATE RESISTANT ISOENZYME; ALKALINE PHOSPHATASE; BROXURIDINE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; NEUROKININ 1 RECEPTOR; OSTEOCALCIN; OSTEOCLAST DIFFERENTIATION FACTOR; SUBSTANCE P; SUBSTANCE P RECEPTOR; TRANSCRIPTION FACTOR RUNX2;

EID: 67649452522     PISSN: 87563282     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bone.2009.04.203     Document Type: Article
Times cited : (139)

References (49)
  • 1
    • 0037098914 scopus 로고    scopus 로고
    • Neuronal regulation of bone metabolism and anabolism: calcitonin gene-related peptide-, substance P-, and tyrosine hydroxylase-containing nerves and the bone
    • Imai S., and Matsusue Y. Neuronal regulation of bone metabolism and anabolism: calcitonin gene-related peptide-, substance P-, and tyrosine hydroxylase-containing nerves and the bone. Microsc. Res. Tech. 58 (2002) 61-69
    • (2002) Microsc. Res. Tech. , vol.58 , pp. 61-69
    • Imai, S.1    Matsusue, Y.2
  • 2
    • 0025727850 scopus 로고
    • Distribution of CGRP-, VIP-, D beta H-, SP-, and NPY-immunoreactive nerves in the periosteum of the rat
    • Hill E.L., and Elde R. Distribution of CGRP-, VIP-, D beta H-, SP-, and NPY-immunoreactive nerves in the periosteum of the rat. Cell. Tissue Res. 264 (1991) 469-480
    • (1991) Cell. Tissue Res. , vol.264 , pp. 469-480
    • Hill, E.L.1    Elde, R.2
  • 4
    • 19944433023 scopus 로고    scopus 로고
    • Capsaicin-sensitive sensory neurons contribute to the maintenance of trabecular bone integrity
    • Offley S.C., Guo T.Z., Wei T., Clark J.D., Vogel H., Lindsey D.P., et al. Capsaicin-sensitive sensory neurons contribute to the maintenance of trabecular bone integrity. J. Bone Miner. Res. 20 (2005) 257-267
    • (2005) J. Bone Miner. Res. , vol.20 , pp. 257-267
    • Offley, S.C.1    Guo, T.Z.2    Wei, T.3    Clark, J.D.4    Vogel, H.5    Lindsey, D.P.6
  • 7
    • 0035191704 scopus 로고    scopus 로고
    • Calcitonin gene related peptide in familial dysautonomia
    • Maayan C., Becker Y., Gesundheit B., and Girgis S.I. Calcitonin gene related peptide in familial dysautonomia. Neuropeptides 35 (2001) 189-195
    • (2001) Neuropeptides , vol.35 , pp. 189-195
    • Maayan, C.1    Becker, Y.2    Gesundheit, B.3    Girgis, S.I.4
  • 8
    • 0019442111 scopus 로고
    • Differential effects of capsaicin on the content of somatostatin, substance P, and neurotensin in the nervous system of the rat
    • Gamse R., Leeman S.E., Holzer P., and Lembeck F. Differential effects of capsaicin on the content of somatostatin, substance P, and neurotensin in the nervous system of the rat. Naunyn. Schmiedebergs Arch. Pharmacol. 317 (1981) 140-148
    • (1981) Naunyn. Schmiedebergs Arch. Pharmacol. , vol.317 , pp. 140-148
    • Gamse, R.1    Leeman, S.E.2    Holzer, P.3    Lembeck, F.4
  • 9
    • 0030571610 scopus 로고    scopus 로고
    • Systemic capsaicin in the adult rat differentially affects gene expression for neuropeptides and neurotrophin receptors in primary sensory neurons
    • Kashiba H., Ueda Y., and Senba E. Systemic capsaicin in the adult rat differentially affects gene expression for neuropeptides and neurotrophin receptors in primary sensory neurons. Neuroscience 76 (1997) 299-312
    • (1997) Neuroscience , vol.76 , pp. 299-312
    • Kashiba, H.1    Ueda, Y.2    Senba, E.3
  • 10
    • 0031851920 scopus 로고    scopus 로고
    • Light- and electron-microscopic study of the distribution of axons containing substance P and the localization of neurokinin-1 receptor in bone
    • Goto T., Yamaza T., Kido M.A., and Tanaka T. Light- and electron-microscopic study of the distribution of axons containing substance P and the localization of neurokinin-1 receptor in bone. Cell. Tissue Res. 293 (1998) 87-93
    • (1998) Cell. Tissue Res. , vol.293 , pp. 87-93
    • Goto, T.1    Yamaza, T.2    Kido, M.A.3    Tanaka, T.4
  • 11
    • 0035200367 scopus 로고    scopus 로고
    • Substance P and substance P receptors in bone and gingival tissues
    • Goto T., Kido M.A., Yamaza T., and Tanaka T. Substance P and substance P receptors in bone and gingival tissues. Med. Electron. Microsc. 34 (2001) 77-85
    • (2001) Med. Electron. Microsc. , vol.34 , pp. 77-85
    • Goto, T.1    Kido, M.A.2    Yamaza, T.3    Tanaka, T.4
  • 12
    • 33846081607 scopus 로고    scopus 로고
    • stimulates late-stage rat osteoblastic bone formation through neurokinin-1 receptors
    • Goto T., Nakao K., Gunjigake K.K., Kido M.A., Kobayashi S., Tanaka T., et al. stimulates late-stage rat osteoblastic bone formation through neurokinin-1 receptors. Neuropeptides 41 (2007) 25-31
    • (2007) Neuropeptides , vol.41 , pp. 25-31
    • Goto, T.1    Nakao, K.2    Gunjigake, K.K.3    Kido, M.A.4    Kobayashi, S.5    Tanaka, T.6
  • 13
    • 0343907213 scopus 로고    scopus 로고
    • Expression of mRNAs for neuropeptide receptors and beta-adrenergic receptors in human osteoblasts and human osteogenic sarcoma cells
    • Togari A., Arai M., Mizutani S., Mizutani S., Koshihara Y., and Nagatsu T. Expression of mRNAs for neuropeptide receptors and beta-adrenergic receptors in human osteoblasts and human osteogenic sarcoma cells. Neurosci. Lett. 233 (1997) 125-128
    • (1997) Neurosci. Lett. , vol.233 , pp. 125-128
    • Togari, A.1    Arai, M.2    Mizutani, S.3    Mizutani, S.4    Koshihara, Y.5    Nagatsu, T.6
  • 14
    • 0030920081 scopus 로고    scopus 로고
    • Neurogenic substance P stimulates osteogenesis in vitro
    • Shih C., and Bernard G.W. Neurogenic substance P stimulates osteogenesis in vitro. Peptides 18 (1997) 323-326
    • (1997) Peptides , vol.18 , pp. 323-326
    • Shih, C.1    Bernard, G.W.2
  • 15
    • 0035041139 scopus 로고    scopus 로고
    • Effect of the neuropeptide substance P on the rat bone marrow-derived osteogenic cells in vitro
    • Adamus M.A., and Dabrowski Z.J. Effect of the neuropeptide substance P on the rat bone marrow-derived osteogenic cells in vitro. J. Cell. Biochem. 81 (2001) 499-506
    • (2001) J. Cell. Biochem. , vol.81 , pp. 499-506
    • Adamus, M.A.1    Dabrowski, Z.J.2
  • 16
    • 4444312989 scopus 로고    scopus 로고
    • Substance P enhances the inhibition of osteoblastic cell differentiation induced by lipopolysaccharide from Porphyromonas gingivalis
    • Azuma H., Kido J., Ikedo D., Kataoka M., and Nagata T. Substance P enhances the inhibition of osteoblastic cell differentiation induced by lipopolysaccharide from Porphyromonas gingivalis. J. Periodontol. 75 (2004) 974-981
    • (2004) J. Periodontol. , vol.75 , pp. 974-981
    • Azuma, H.1    Kido, J.2    Ikedo, D.3    Kataoka, M.4    Nagata, T.5
  • 17
    • 0026759671 scopus 로고
    • Neuroendocrine regulation of cyclic AMP formation in osteoblastic cell lines (UMR-106-01, ROS 17/2.8, MC3T3-E1, and Saos-2) and primary bone cells
    • Bjurholm A., Kreicbergs A., Schultzberg M., and Lerner U.H. Neuroendocrine regulation of cyclic AMP formation in osteoblastic cell lines (UMR-106-01, ROS 17/2.8, MC3T3-E1, and Saos-2) and primary bone cells. J. Bone Miner. Res. 7 (1992) 1011-1019
    • (1992) J. Bone Miner. Res. , vol.7 , pp. 1011-1019
    • Bjurholm, A.1    Kreicbergs, A.2    Schultzberg, M.3    Lerner, U.H.4
  • 18
    • 0037650080 scopus 로고    scopus 로고
    • Global amplification polymerase chain reaction reveals novel transitional stages during osteoprogenitor differentiation
    • Liu F., Malaval L., and Aubin J.E. Global amplification polymerase chain reaction reveals novel transitional stages during osteoprogenitor differentiation. J. Cell. Sci. 116 (2003) 1787-1796
    • (2003) J. Cell. Sci. , vol.116 , pp. 1787-1796
    • Liu, F.1    Malaval, L.2    Aubin, J.E.3
  • 20
    • 12244296438 scopus 로고    scopus 로고
    • Changes in Runx2/Cbfa1 expression and activity during osteoblastic differentiation of human bone marrow stromal cells
    • Shui C., Spelsberg T.C., Riggs B.L., and Khosla S. Changes in Runx2/Cbfa1 expression and activity during osteoblastic differentiation of human bone marrow stromal cells. J. Bone Miner. Res. 18 (2003) 213-221
    • (2003) J. Bone Miner. Res. , vol.18 , pp. 213-221
    • Shui, C.1    Spelsberg, T.C.2    Riggs, B.L.3    Khosla, S.4
  • 21
    • 0033610070 scopus 로고    scopus 로고
    • regulates the function of rabbit cultured osteoclast; increase of intracellular free calcium concentration and enhancement of bone resorption
    • Mori T., Ogata T., Okumura H., Shibata T., Nakamura Y., Kataoka K., et al. regulates the function of rabbit cultured osteoclast; increase of intracellular free calcium concentration and enhancement of bone resorption. Biochem. Biophys. Res. Commun. 262 (1999) 418-422
    • (1999) Biochem. Biophys. Res. Commun. , vol.262 , pp. 418-422
    • Mori, T.1    Ogata, T.2    Okumura, H.3    Shibata, T.4    Nakamura, Y.5    Kataoka, K.6
  • 22
    • 14344254739 scopus 로고    scopus 로고
    • Substance P upregulates osteoclastogenesis by activating nuclear factor kappa B in osteoclast precursors
    • Sohn S.J. Substance P upregulates osteoclastogenesis by activating nuclear factor kappa B in osteoclast precursors. Acta Otolaryngol. 125 (2005) 130-133
    • (2005) Acta Otolaryngol. , vol.125 , pp. 130-133
    • Sohn, S.J.1
  • 24
    • 0042838268 scopus 로고    scopus 로고
    • bFGF administration lowers the phosphate threshold for mineralization in bone marrow stromal cells
    • Nauman E.A., Sakata T., Keaveny T.M., Halloran B.P., and Bikle D.D. bFGF administration lowers the phosphate threshold for mineralization in bone marrow stromal cells. Calcif. Tissue Int. 73 (2003) 147-152
    • (2003) Calcif. Tissue Int. , vol.73 , pp. 147-152
    • Nauman, E.A.1    Sakata, T.2    Keaveny, T.M.3    Halloran, B.P.4    Bikle, D.D.5
  • 25
    • 4043065189 scopus 로고    scopus 로고
    • The HIV protease inhibitor ritonavir blocks osteoclastogenesis and function by impairing RANKL-induced signaling
    • Wang M.W., Wei S., Faccio R., Takeshita S., Tebas P., Powderly W.G., et al. The HIV protease inhibitor ritonavir blocks osteoclastogenesis and function by impairing RANKL-induced signaling. J. Clin. Invest. 114 (2004) 206-213
    • (2004) J. Clin. Invest. , vol.114 , pp. 206-213
    • Wang, M.W.1    Wei, S.2    Faccio, R.3    Takeshita, S.4    Tebas, P.5    Powderly, W.G.6
  • 26
    • 0029043459 scopus 로고
    • Substance P (SP) mediates production of stem cell factor and interleukin-1 in bone marrow stroma: potential autoregulatory role for these cytokines in SP receptor expression and induction
    • Rameshwar P., and Gascon P. Substance P (SP) mediates production of stem cell factor and interleukin-1 in bone marrow stroma: potential autoregulatory role for these cytokines in SP receptor expression and induction. Blood 86 (1995) 482-490
    • (1995) Blood , vol.86 , pp. 482-490
    • Rameshwar, P.1    Gascon, P.2
  • 27
    • 0027464306 scopus 로고
    • In vitro stimulatory effect of substance P on hematopoiesis
    • Rameshwar P., Ganea D., and Gascon P. In vitro stimulatory effect of substance P on hematopoiesis. Blood 81 (1993) 391-398
    • (1993) Blood , vol.81 , pp. 391-398
    • Rameshwar, P.1    Ganea, D.2    Gascon, P.3
  • 28
    • 0031112418 scopus 로고    scopus 로고
    • Receptor induction regulates the synergistic effects of substance P with IL-1 and platelet-derived growth factor on the proliferation of bone marrow fibroblasts
    • Rameshwar P., Poddar A., Zhu G., and Gascon P. Receptor induction regulates the synergistic effects of substance P with IL-1 and platelet-derived growth factor on the proliferation of bone marrow fibroblasts. J. Immunol. 158 (1997) 3417-3424
    • (1997) J. Immunol. , vol.158 , pp. 3417-3424
    • Rameshwar, P.1    Poddar, A.2    Zhu, G.3    Gascon, P.4
  • 29
    • 17844376765 scopus 로고    scopus 로고
    • Integrin binding specificity regulates biomaterial surface chemistry effects on cell differentiation
    • Keselowsky B.G., Collard D.M., and Garcia A.J. Integrin binding specificity regulates biomaterial surface chemistry effects on cell differentiation. Proc. Natl. Acad. Sci. U. S. A. 102 (2005) 5953-5957
    • (2005) Proc. Natl. Acad. Sci. U. S. A. , vol.102 , pp. 5953-5957
    • Keselowsky, B.G.1    Collard, D.M.2    Garcia, A.J.3
  • 30
    • 8344254362 scopus 로고    scopus 로고
    • The vitamin D receptor is present in caveolae-enriched plasma membranes and binds 1 alpha,25(OH)2-vitamin D3 in vivo and in vitro
    • Huhtakangas J.A., Olivera C.J., Bishop J.E., Zanello L.P., and Norman A.W. The vitamin D receptor is present in caveolae-enriched plasma membranes and binds 1 alpha,25(OH)2-vitamin D3 in vivo and in vitro. Mol. Endocrinol. 18 (2004) 2660-2671
    • (2004) Mol. Endocrinol. , vol.18 , pp. 2660-2671
    • Huhtakangas, J.A.1    Olivera, C.J.2    Bishop, J.E.3    Zanello, L.P.4    Norman, A.W.5
  • 31
    • 17044405446 scopus 로고    scopus 로고
    • Spinal CK2 regulates nociceptive signaling in models of inflammatory pain
    • Li X., Shi X., Liang D.Y., and Clark J.D. Spinal CK2 regulates nociceptive signaling in models of inflammatory pain. Pain 115 (2005) 182-190
    • (2005) Pain , vol.115 , pp. 182-190
    • Li, X.1    Shi, X.2    Liang, D.Y.3    Clark, J.D.4
  • 32
    • 34547124586 scopus 로고    scopus 로고
    • NF-kappaB p50 and p52 regulate receptor activator of NF-kappaB ligand (RANKL) and tumor necrosis factor-induced osteoclast precursor differentiation by activating c-Fos and NFATc1
    • Yamashita T., Yao Z., Li F., Zhang Q., Badell I.R., Schwarz E.M., et al. NF-kappaB p50 and p52 regulate receptor activator of NF-kappaB ligand (RANKL) and tumor necrosis factor-induced osteoclast precursor differentiation by activating c-Fos and NFATc1. J. Biol. Chem. 282 (2007) 18245-18253
    • (2007) J. Biol. Chem. , vol.282 , pp. 18245-18253
    • Yamashita, T.1    Yao, Z.2    Li, F.3    Zhang, Q.4    Badell, I.R.5    Schwarz, E.M.6
  • 33
    • 0037098917 scopus 로고    scopus 로고
    • Tachykinins and tachykinin receptors in bone
    • Goto T., and Tanaka T. Tachykinins and tachykinin receptors in bone. Microsc. Res. Tech. 58 (2002) 91-97
    • (2002) Microsc. Res. Tech. , vol.58 , pp. 91-97
    • Goto, T.1    Tanaka, T.2
  • 34
    • 0025316785 scopus 로고
    • Progressive development of the rat osteoblast phenotype in vitro: reciprocal relationships in expression of genes associated with osteoblast proliferation and differentiation during formation of the bone extracellular matrix
    • Owen T.A., Aronow M., Shalhoub V., Barone L.M., Wilming L., Tassinari M.S., et al. Progressive development of the rat osteoblast phenotype in vitro: reciprocal relationships in expression of genes associated with osteoblast proliferation and differentiation during formation of the bone extracellular matrix. J. Cell. Physiol. 143 (1990) 420-430
    • (1990) J. Cell. Physiol. , vol.143 , pp. 420-430
    • Owen, T.A.1    Aronow, M.2    Shalhoub, V.3    Barone, L.M.4    Wilming, L.5    Tassinari, M.S.6
  • 36
    • 33645801215 scopus 로고    scopus 로고
    • Substance P stimulates release of RANKL via COX-2 expression in human dental pulp cells
    • Kojima T., Yamaguchi M., and Kasai K. Substance P stimulates release of RANKL via COX-2 expression in human dental pulp cells. Inflamm. Res. 55 (2006) 78-84
    • (2006) Inflamm. Res. , vol.55 , pp. 78-84
    • Kojima, T.1    Yamaguchi, M.2    Kasai, K.3
  • 37
    • 12944262423 scopus 로고    scopus 로고
    • RANK is the intrinsic hematopoietic cell surface receptor that controls osteoclastogenesis and regulation of bone mass and calcium metabolism
    • Li J., Sarosi I., Yan X.Q., Morony S., Capparelli C., Tan H.L., et al. RANK is the intrinsic hematopoietic cell surface receptor that controls osteoclastogenesis and regulation of bone mass and calcium metabolism. Proc. Natl. Acad. Sci. U. S. A. 97 (2000) 1566-1571
    • (2000) Proc. Natl. Acad. Sci. U. S. A. , vol.97 , pp. 1566-1571
    • Li, J.1    Sarosi, I.2    Yan, X.Q.3    Morony, S.4    Capparelli, C.5    Tan, H.L.6
  • 38
    • 0033611467 scopus 로고    scopus 로고
    • OPGL is a key regulator of osteoclastogenesis, lymphocyte development and lymph-node organogenesis
    • Kong Y.Y., Yoshida H., Sarosi I., Tan H.L., Timms E., Capparelli C., et al. OPGL is a key regulator of osteoclastogenesis, lymphocyte development and lymph-node organogenesis. Nature 397 (1999) 315-323
    • (1999) Nature , vol.397 , pp. 315-323
    • Kong, Y.Y.1    Yoshida, H.2    Sarosi, I.3    Tan, H.L.4    Timms, E.5    Capparelli, C.6
  • 39
    • 0034523328 scopus 로고    scopus 로고
    • TNF-alpha induces osteoclastogenesis by direct stimulation of macrophages exposed to permissive levels of RANK ligand
    • Lam J., Takeshita S., Barker J.E., Kanagawa O., Ross F.P., and Teitelbaum S.L. TNF-alpha induces osteoclastogenesis by direct stimulation of macrophages exposed to permissive levels of RANK ligand. J. Clin. Invest. 106 (2000) 1481-1488
    • (2000) J. Clin. Invest. , vol.106 , pp. 1481-1488
    • Lam, J.1    Takeshita, S.2    Barker, J.E.3    Kanagawa, O.4    Ross, F.P.5    Teitelbaum, S.L.6
  • 40
    • 14044249546 scopus 로고    scopus 로고
    • Convergent signaling by acidosis and receptor activator of NF-kappaB ligand (RANKL) on the calcium/calcineurin/NFAT pathway in osteoclasts
    • Komarova S.V., Pereverzev A., Shum J.W., Sims S.M., and Dixon S.J. Convergent signaling by acidosis and receptor activator of NF-kappaB ligand (RANKL) on the calcium/calcineurin/NFAT pathway in osteoclasts. Proc. Natl. Acad. Sci. U. S. A. 102 (2005) 2643-2648
    • (2005) Proc. Natl. Acad. Sci. U. S. A. , vol.102 , pp. 2643-2648
    • Komarova, S.V.1    Pereverzev, A.2    Shum, J.W.3    Sims, S.M.4    Dixon, S.J.5
  • 41
    • 0037424516 scopus 로고    scopus 로고
    • RANK ligand-induced elevation of cytosolic Ca2+ accelerates nuclear translocation of nuclear factor kappa B in osteoclasts
    • Komarova S.V., Pilkington M.F., Weidema A.F., Dixon S.J., and Sims S.M. RANK ligand-induced elevation of cytosolic Ca2+ accelerates nuclear translocation of nuclear factor kappa B in osteoclasts. J. Biol. Chem. 278 (2003) 8286-8293
    • (2003) J. Biol. Chem. , vol.278 , pp. 8286-8293
    • Komarova, S.V.1    Pilkington, M.F.2    Weidema, A.F.3    Dixon, S.J.4    Sims, S.M.5
  • 42
    • 0031573083 scopus 로고    scopus 로고
    • The neuropeptide substance P activates transcription factor NF-kappa B and kappa B-dependent gene expression in human astrocytoma cells
    • Lieb K., Fiebich B.L., Berger M., Bauer J., and Schulze-Osthoff K. The neuropeptide substance P activates transcription factor NF-kappa B and kappa B-dependent gene expression in human astrocytoma cells. J. Immunol. 159 (1997) 4952-4958
    • (1997) J. Immunol. , vol.159 , pp. 4952-4958
    • Lieb, K.1    Fiebich, B.L.2    Berger, M.3    Bauer, J.4    Schulze-Osthoff, K.5
  • 43
    • 0033571073 scopus 로고    scopus 로고
    • Substance P activates coincident NF-AT- and NF-kappa B-dependent adhesion molecule gene expression in microvascular endothelial cells through intracellular calcium mobilization
    • Quinlan K.L., Naik S.M., Cannon G., Armstrong C.A., Bunnett N.W., Ansel J.C., et al. Substance P activates coincident NF-AT- and NF-kappa B-dependent adhesion molecule gene expression in microvascular endothelial cells through intracellular calcium mobilization. J. Immunol. 163 (1999) 5656-5665
    • (1999) J. Immunol. , vol.163 , pp. 5656-5665
    • Quinlan, K.L.1    Naik, S.M.2    Cannon, G.3    Armstrong, C.A.4    Bunnett, N.W.5    Ansel, J.C.6
  • 44
    • 0033992327 scopus 로고    scopus 로고
    • Substance P activates NF-kappaB independent of elevations in intracellular calcium in murine macrophages and dendritic cells
    • Marriott I., Mason M.J., Elhofy A., and Bost K.L. Substance P activates NF-kappaB independent of elevations in intracellular calcium in murine macrophages and dendritic cells. J. Neuroimmunol. 102 (2000) 163-171
    • (2000) J. Neuroimmunol. , vol.102 , pp. 163-171
    • Marriott, I.1    Mason, M.J.2    Elhofy, A.3    Bost, K.L.4
  • 45
    • 0344738646 scopus 로고    scopus 로고
    • Serum substance P concentrations and silent aspiration in elderly patients with stroke
    • Arai T., Yoshimi N., Fujiwara H., and Sekizawa K. Serum substance P concentrations and silent aspiration in elderly patients with stroke. Neurology 61 (2003) 1625-1626
    • (2003) Neurology , vol.61 , pp. 1625-1626
    • Arai, T.1    Yoshimi, N.2    Fujiwara, H.3    Sekizawa, K.4
  • 46
    • 0027298877 scopus 로고
    • Neutral endopeptidase (3.4.24.11) in plasma and synovial fluid of patients with rheumatoid arthritis. A marker of disease activity or a regulator of pain and inflammation
    • Matucci-Cerinic M., Lombardi A., Leoncini G., Pignone A., Sacerdoti L., Spillantini M.G., et al. Neutral endopeptidase (3.4.24.11) in plasma and synovial fluid of patients with rheumatoid arthritis. A marker of disease activity or a regulator of pain and inflammation. Rheumatol. Int. 13 (1993) 1-4
    • (1993) Rheumatol. Int. , vol.13 , pp. 1-4
    • Matucci-Cerinic, M.1    Lombardi, A.2    Leoncini, G.3    Pignone, A.4    Sacerdoti, L.5    Spillantini, M.G.6
  • 47
    • 20144370371 scopus 로고    scopus 로고
    • Levels of gastrin-releasing peptide and substance P in synovial fluid and serum correlate with levels of cytokines in rheumatoid arthritis
    • Grimsholm O., Rantapaa-Dahlqvist S., and Forsgren S. Levels of gastrin-releasing peptide and substance P in synovial fluid and serum correlate with levels of cytokines in rheumatoid arthritis. Arthritis Res. Ther. 7 (2005) R416-R426
    • (2005) Arthritis Res. Ther. , vol.7
    • Grimsholm, O.1    Rantapaa-Dahlqvist, S.2    Forsgren, S.3
  • 48
    • 0031028018 scopus 로고    scopus 로고
    • Substance P level in synovial fluid may predict pain relief after knee replacement
    • Pritchett J.W. Substance P level in synovial fluid may predict pain relief after knee replacement. J. Bone. Joint. Surg. Br. 79 (1997) 114-116
    • (1997) J. Bone. Joint. Surg. Br. , vol.79 , pp. 114-116
    • Pritchett, J.W.1
  • 49
    • 47249143811 scopus 로고    scopus 로고
    • Substance P enhances NF-kappaB transactivation and chemokine response in murine macrophages via ERK1/2 and p38 MAPK signaling pathways
    • Sun J., Ramnath R.D., Zhi L., Tamizhselvi R., and Bhatia M. Substance P enhances NF-kappaB transactivation and chemokine response in murine macrophages via ERK1/2 and p38 MAPK signaling pathways. Am. J. Physiol. Cell. Physiol. 294 (2008) C1586-C1596
    • (2008) Am. J. Physiol. Cell. Physiol. , vol.294
    • Sun, J.1    Ramnath, R.D.2    Zhi, L.3    Tamizhselvi, R.4    Bhatia, M.5


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