메뉴 건너뛰기




Volumn 28, Issue 7, 2014, Pages 1529-1536

Replacement of bortezomib with carfilzomib for multiple myeloma patients progressing from bortezomib combination therapy

(13)  Berenson, J R a,b,c   Hilger, J D b   Yellin, O b   Dichmann, R d   Patel Donnelly, D d   Boccia, R V e   Bessudo, A f   Stampleman, L g   Gravenor, D h   Eshaghian, S i   Nassir, Y j   Swift, R A c   Vescio, R A i  


Author keywords

bortezomib; carfilzomib; multiple myeloma; proteasome inhibitor; refractory; relapsed

Indexed keywords

ASCORBIC ACID; BENDAMUSTINE; BORTEZOMIB; CARFILZOMIB; CLARITHROMYCIN; CREATININE; CYCLOPHOSPHAMIDE; DEXAMETHASONE; DOXORUBICIN; LENALIDOMIDE; MELPHALAN; METHYLPREDNISOLONE; STEROID; THALIDOMIDE;

EID: 84904054234     PISSN: 08876924     EISSN: 14765551     Source Type: Journal    
DOI: 10.1038/leu.2014.27     Document Type: Article
Times cited : (58)

References (37)
  • 1
    • 84898627587 scopus 로고    scopus 로고
    • Cancer Facts & Figures
    • Cancer Facts & Figures. Am Cancer Soc 2013.
    • (2013) Am Cancer Soc
  • 3
    • 84856719479 scopus 로고    scopus 로고
    • Risk of progression and survival in multiple myeloma relapsing after therapy with IMiDs and bortezomib a multicenter international myeloma working group study
    • Kumar SK, Lee JH, Lahuerta JJ, Morgan G, Richardson PG, Crowley J et al. Risk of progression and survival in multiple myeloma relapsing after therapy with IMiDs and bortezomib a multicenter international myeloma working group study. Leukemia 2012 26 149-157.
    • (2012) Leukemia , vol.26 , pp. 149-157
    • Kumar, S.K.1    Lee, J.H.2    Lahuerta, J.J.3    Morgan, G.4    Richardson, P.G.5    Crowley, J.6
  • 4
    • 84867295563 scopus 로고    scopus 로고
    • A phase 2 study of single-agent carfilzomib (PX-171-003-A1) in patients with relapsed and refractory multiple myeloma
    • Siegel DS, Martin T, Wang M, Vij R, Jakubowiak AJ, Lonial S et al. A phase 2 study of single-agent carfilzomib (PX-171-003-A1) in patients with relapsed and refractory multiple myeloma. Blood 2012 120 2817-2825.
    • (2012) Blood , vol.120 , pp. 2817-2825
    • Siegel, D.S.1    Martin, T.2    Wang, M.3    Vij, R.4    Jakubowiak, A.J.5    Lonial, S.6
  • 5
    • 84904034619 scopus 로고    scopus 로고
    • Inc. South San Francisco C Krypolis Prescribing Information
    • Onix Pharmaceuticals, Inc. South San Francisco C. Krypolis Prescribing Information 2013.
    • (2013) Onix Pharmaceuticals
  • 6
    • 84865552564 scopus 로고    scopus 로고
    • An open-label, single-arm, phase 2 study of single-agent carfilzomib in patients with relapsed and/or refractory multiple myeloma who have been previously treated with bortezomib
    • Vij R, Siegel DS, Jagannath S, Jakubowiak AJ, Stewart AK, McDonagh K et al. An open-label, single-arm, phase 2 study of single-agent carfilzomib in patients with relapsed and/or refractory multiple myeloma who have been previously treated with bortezomib. Br J Haematol 2012 158 739-748.
    • (2012) Br J Haematol , vol.158 , pp. 739-748
    • Vij, R.1    Siegel, D.S.2    Jagannath, S.3    Jakubowiak, A.J.4    Stewart, A.K.5    McDonagh, K.6
  • 7
    • 80051869676 scopus 로고    scopus 로고
    • Efficacy of retreatment with immunomodulatory drugs (IMiDs) in patients receiving IMiDs for initial therapy of newly diagnosed multiple myeloma
    • Madan S, Lacy MQ, Dispenzieri A, Gertz MA, Buadi F, Hayman SR et al. Efficacy of retreatment with immunomodulatory drugs (IMiDs) in patients receiving IMiDs for initial therapy of newly diagnosed multiple myeloma. Blood 2011 118 1763-1765.
    • (2011) Blood , vol.118 , pp. 1763-1765
    • Madan, S.1    Lacy, M.Q.2    Dispenzieri, A.3    Gertz, M.A.4    Buadi, F.5    Hayman, S.R.6
  • 8
    • 70349515834 scopus 로고    scopus 로고
    • Retreatment with bortezomib alone or in combination for patients with multiple myeloma following an initial response to bortezomib
    • Sood R, Carloss H, Kerr R, Lopez J, Lee M, Druck M et al. Retreatment with bortezomib alone or in combination for patients with multiple myeloma following an initial response to bortezomib. Am J Hematol 2009 84 657-660.
    • (2009) Am J Hematol , vol.84 , pp. 657-660
    • Sood, R.1    Carloss, H.2    Kerr, R.3    Lopez, J.4    Lee, M.5    Druck, M.6
  • 9
    • 84860749854 scopus 로고    scopus 로고
    • Effective response with bortezomib retreatment in relapsed multiple myeloma-a multicentre retrospective survey in Switzerland
    • Taverna C, Voegeli J, Trojan A, Olie Ra, von Rohr A. Effective response with bortezomib retreatment in relapsed multiple myeloma-a multicentre retrospective survey in Switzerland. Swiss Med Wkly 2012 142 w13562.
    • (2012) Swiss Med Wkly , vol.142
    • Taverna, C.1    Voegeli, J.2    Trojan, A.3    Ra, O.4    Von Rohr, A.5
  • 10
    • 84873990173 scopus 로고    scopus 로고
    • A prospective, international phase 2 study of bortezomib retreatment in patients with relapsed multiple myeloma
    • Petrucci MT, Giraldo P, Corradini P, Teixeira A, Dimopoulos MA, Blau IW et al. A prospective, international phase 2 study of bortezomib retreatment in patients with relapsed multiple myeloma. Br J Haematol 2013 160 649-659.
    • (2013) Br J Haematol , vol.160 , pp. 649-659
    • Petrucci, M.T.1    Giraldo, P.2    Corradini, P.3    Teixeira, A.4    Dimopoulos, M.A.5    Blau, I.W.6
  • 11
    • 84863775772 scopus 로고    scopus 로고
    • A phase 2 study of pegylated liposomal doxorubicin, bortezomib, dexamethasone and lenalidomide for patients with relapsed/refractory multiple myeloma.
    • Berenson JR, Yellin O, Kazamel T, Hilger JD, Chen C-S, Cartmell a et al. A phase 2 study of pegylated liposomal doxorubicin, bortezomib, dexamethasone and lenalidomide for patients with relapsed/refractory multiple myeloma. Leukemia 2012 26 1675-1680.
    • (2012) Leukemia , vol.26 , pp. 1675-1680
    • Berenson, J.R.1    Yellin, O.2    Kazamel, T.3    Hilger, J.D.4    Chen, C.-S.5    Cartmell, A.6
  • 12
    • 84872512168 scopus 로고    scopus 로고
    • Phase I/II trial assessing bendamustine plus bortezomib combination therapy for the treatment of patients with relapsed or refractory multiple myeloma
    • Berenson JR, Yellin O, Bessudo A, Boccia RV, Noga SJ, Gravenor DS et al. Phase I/II trial assessing bendamustine plus bortezomib combination therapy for the treatment of patients with relapsed or refractory multiple myeloma. Br J Haematol 2013 160 321-330.
    • (2013) Br J Haematol , vol.160 , pp. 321-330
    • Berenson, J.R.1    Yellin, O.2    Bessudo, A.3    Boccia, R.V.4    Noga, S.J.5    Gravenor, D.S.6
  • 13
    • 80051691845 scopus 로고    scopus 로고
    • In vitro and in vivo selective antitumor activity of a novel orally bioavailable proteasome inhibitor MLN9708 against multiple myeloma cells.
    • Chauhan D, Tian Z, Zhou B, Kuhn D, Orlowski R, Raje N et al. In vitro and in vivo selective antitumor activity of a novel orally bioavailable proteasome inhibitor MLN9708 against multiple myeloma cells. Clin Cancer Res 2011 17 5311-5321.
    • (2011) Clin Cancer Res , vol.17 , pp. 5311-5321
    • Chauhan, D.1    Tian, Z.2    Zhou, B.3    Kuhn, D.4    Orlowski, R.5    Raje, N.6
  • 14
    • 36148944490 scopus 로고    scopus 로고
    • Potent activity of carfilzomib, a novel, irreversible inhibitor of the ubiquitin-proteasome pathway, against preclinical models of multiple myeloma
    • Kuhn DJ, Chen Q, Voorhees PM, Strader JS, Shenk KD, Sun CM et al. Potent activity of carfilzomib, a novel, irreversible inhibitor of the ubiquitin-proteasome pathway, against preclinical models of multiple myeloma. Blood 2007 110 3281-3290.
    • (2007) Blood , vol.110 , pp. 3281-3290
    • Kuhn, D.J.1    Chen, Q.2    Voorhees, P.M.3    Strader, J.S.4    Shenk, K.D.5    Sun, C.M.6
  • 16
    • 84866341173 scopus 로고    scopus 로고
    • CEP-18770 (delanzomib) in combination with dexamethasone and lenalidomide inhibits the growth of multiple myeloma
    • Sanchez E, Li M, Li J, Wang C, Chen H, Jones-Bolin S et al. CEP-18770 (delanzomib) in combination with dexamethasone and lenalidomide inhibits the growth of multiple myeloma. Leuk Res 2012 36 1422-1427.
    • (2012) Leuk Res , vol.36 , pp. 1422-1427
    • Sanchez, E.1    Li, M.2    Li, J.3    Wang, C.4    Chen, H.5    Jones-Bolin, S.6
  • 17
    • 84865333050 scopus 로고    scopus 로고
    • A phase 1/2 study of carfilzomib in combination with lenalidomide and low-dose dexamethasone as a frontline treatment for multiple myeloma
    • Jakubowiak AJ, Dytfeld D, Griffith KA, Lebovic D, Vesole DH, Jagannath S et al. A phase 1/2 study of carfilzomib in combination with lenalidomide and low-dose dexamethasone as a frontline treatment for multiple myeloma. Blood 2012 120 1801-1809.
    • (2012) Blood , vol.120 , pp. 1801-1809
    • Jakubowiak, A.J.1    Dytfeld, D.2    Griffith, K.A.3    Lebovic, D.4    Vesole, D.H.5    Jagannath, S.6
  • 18
    • 84887609779 scopus 로고    scopus 로고
    • Phase 2 dose-expansion study (PX-171-006) of carfilzomib, lenalidomide and low-dose dexamethasone in relapsed or progressive multiple myeloma
    • Wang M, Martin T, Bensinger W, Alsina M, Siegel DS, Kavalerchik E et al. Phase 2 dose-expansion study (PX-171-006) of carfilzomib, lenalidomide and low-dose dexamethasone in relapsed or progressive multiple myeloma. Blood 2013 122 3122-3128.
    • (2013) Blood , vol.122 , pp. 3122-3128
    • Wang, M.1    Martin, T.2    Bensinger, W.3    Alsina, M.4    Siegel, D.S.5    Kavalerchik, E.6
  • 19
    • 18244428600 scopus 로고    scopus 로고
    • Criteria for evaluating disease response and progression in patients with multiple myeloma treated by high-dose therapy and haemopoietic stem cell transplantation
    • BladÉ J, Samson D, Reece D, Apperley J, BJÖ rkstrand B, Gahrton Gö et al. Criteria for evaluating disease response and progression in patients with multiple myeloma treated by high-dose therapy and haemopoietic stem cell transplantation. Br J Haematol 1998 102 1115-1123.
    • (1998) Br J Haematol , vol.102 , pp. 1115-1123
    • Bladé, J.1    Samson, D.2    Reece, D.3    Apperley, J.4    Björkstrand, B.5    Gö, G.6
  • 21
    • 0029851283 scopus 로고    scopus 로고
    • A note on quantifying follow-up in studies of failure time
    • Schemper M, Smith TL. A note on quantifying follow-up in studies of failure time. Control Clin Trials 1996 17 343-346.
    • (1996) Control Clin Trials , vol.17 , pp. 343-346
    • Schemper, M.1    Smith, T.L.2
  • 22
    • 84887007753 scopus 로고    scopus 로고
    • Integrated safety profile of single-agent carfilzomib experience from 526 patients enrolled in 4 phase II clinical studies
    • Siegel D, Martin T, Nooka A, Harvey RD, Vij R, Niesvizky R et al. Integrated safety profile of single-agent carfilzomib experience from 526 patients enrolled in 4 phase II clinical studies. Haematologica 2013 98 1753-1761.
    • (2013) Haematologica , vol.98 , pp. 1753-1761
    • Siegel, D.1    Martin, T.2    Nooka, A.3    Harvey, R.D.4    Vij, R.5    Niesvizky, R.6
  • 23
    • 84880119544 scopus 로고    scopus 로고
    • Phase II clinical and correlative study of carfilzomib, lenalidomide, and dexamethasone (CRd) in newly diagnosed multiple myeloma (MM) patients
    • Korde N, Zingone A, Kwok M, Manasanch EE, Costello R, Zuchlinski D et al. Phase II clinical and correlative study of carfilzomib, lenalidomide, and dexamethasone (CRd) in newly diagnosed multiple myeloma (MM) patients. ASH Annu Meet Abstr 2012 120 732.
    • (2012) ASH Annu Meet Abstr , vol.120 , pp. 732
    • Korde, N.1    Zingone, A.2    Kwok, M.3    Manasanch, E.E.4    Costello, R.5    Zuchlinski, D.6
  • 24
    • 84877089105 scopus 로고    scopus 로고
    • Phase Ib dose-escalation study (PX-171-006) of carfilzomib, lenalidomide, and low-dose dexamethasone in relapsed or progressive multiple myeloma
    • Niesvizky R, Martin TG, Bensinger WI, Alsina M, Siegel DS, Kunkel LA et al. Phase Ib dose-escalation study (PX-171-006) of carfilzomib, lenalidomide, and low-dose dexamethasone in relapsed or progressive multiple myeloma. Clin Cancer Res 2013 19 2248-2256.
    • (2013) Clin Cancer Res , vol.19 , pp. 2248-2256
    • Niesvizky, R.1    Martin, T.G.2    Bensinger, W.I.3    Alsina, M.4    Siegel, D.S.5    Kunkel, L.A.6
  • 25
    • 84886920897 scopus 로고    scopus 로고
    • Phase 1b study of 30-minute infusion carfilzomib 20/45 and 20/56 mg/m2 plus 40mg weekly dexamethasone in patients with relapsed and/or refractory (R/R) multiple myeloma
    • Badros AZ, Papadopoulos KP, Zojwalla N, Lee JR, Siegel DSA. Phase 1b study of 30-minute infusion carfilzomib 20/45 and 20/56 mg/m2 plus 40mg weekly dexamethasone in patients with relapsed and/or refractory (R/R) multiple myeloma. ASH Annu Meet Abstr 2012 120 4036.
    • (2012) ASH Annu Meet Abstr , vol.120 , pp. 4036
    • Badros, A.Z.1    Papadopoulos, K.P.2    Zojwalla, N.3    Lee, J.R.4    Siegel, D.S.A.5
  • 26
    • 84884221713 scopus 로고    scopus 로고
    • A multi-center phase I/II trial of carfilzomib and pomalidomide with dexamethasone (Car-Pom-d) in patients with relapsed/refractory multiple myeloma
    • Shah JJ, Stadtmauer EA, Abonour R, Cohen AD, Bensinger WI, Gasparetto C et al. A multi-center phase I/II trial of carfilzomib and pomalidomide with dexamethasone (Car-Pom-d) in patients with relapsed/refractory multiple myeloma. ASH Annu Meet Abstr 2012 120 74.
    • (2012) ASH Annu Meet Abstr , vol.120 , pp. 74
    • Shah, J.J.1    Stadtmauer, E.A.2    Abonour, R.3    Cohen, A.D.4    Bensinger, W.I.5    Gasparetto, C.6
  • 27
    • 84893247056 scopus 로고    scopus 로고
    • Effect of CMP, carfilzomib (CFZ) plus melphalan-prednisone (MP), on response rates in elderly patients (pts) with newly diagnosed multiple myeloma (NDMM) results of a phase (Ph) I/II trial
    • Touzeau C, Kolb B, Hulin C, Caillot D, Benboubker L, Tiab M et al. Effect of CMP, carfilzomib (CFZ) plus melphalan-prednisone (MP), on response rates in elderly patients (pts) with newly diagnosed multiple myeloma (NDMM) results of a phase (Ph) I/II trial. J Clin Oncol 2013 31 8513.
    • (2013) J Clin Oncol , vol.31 , pp. 8513
    • Touzeau, C.1    Kolb, B.2    Hulin, C.3    Caillot, D.4    Benboubker, L.5    Tiab, M.6
  • 28
    • 84884214958 scopus 로고    scopus 로고
    • Carfilzomib, cyclophosphamide and dexamethasone (CCd) for newly diagnosed multiple myeloma (MM) patients
    • Palumbo A, Bringhen S, Villani O, Siniscalchi A, Russo E, Uccello G et al. Carfilzomib, cyclophosphamide and dexamethasone (CCd) for newly diagnosed multiple myeloma (MM) patients. ASH Annu Meet Abstr 2012 120 730.
    • (2012) ASH Annu Meet Abstr , vol.120 , pp. 730
    • Palumbo, A.1    Bringhen, S.2    Villani, O.3    Siniscalchi, A.4    Russo, E.5    Uccello, G.6
  • 29
    • 84879578512 scopus 로고    scopus 로고
    • Carfilzomib combined with thalidomide and dexamethasone (CTD) is an highly effective induction and consolidation treatment in newly diagnosed patients with multiple myeloma (MM) who are transplant candidate
    • Sonneveld P, Asselbergs E, Zweegman S, Van der Holt B, Kersten MJ, Vellenga E et al. Carfilzomib combined with thalidomide and dexamethasone (CTD) is an highly effective induction and consolidation treatment in newly diagnosed patients with multiple myeloma (MM) who are transplant candidate. ASH Annu Meet Abstr 2012 120 333.
    • (2012) ASH Annu Meet Abstr , vol.120 , pp. 333
    • Sonneveld, P.1    Asselbergs, E.2    Zweegman, S.3    Van Der Holt, B.4    Kersten, M.J.5    Vellenga, E.6
  • 30
    • 84879569480 scopus 로고    scopus 로고
    • Results from the phase II dose expansion of cyclophosphamide, carfilzomib, thalidomide and dexamethasone (CYCLONE) in patients with newly diagnosed multiple myeloma
    • Mikhael JR, Reeder CB, Libby ENI, Costa LJ, Bergsagel PL, Buadi F et al. Results from the phase II dose expansion of cyclophosphamide, carfilzomib, thalidomide and dexamethasone (CYCLONE) in patients with newly diagnosed multiple myeloma. ASH Annu Meet Abstr 2012 120 445.
    • (2012) ASH Annu Meet Abstr , vol.120 , pp. 445
    • Mikhael, J.R.1    Reeder, C.B.2    Libby, E.N.I.S.3    Costa, L.J.4    Bergsagel, P.L.5    Buadi, F.6
  • 31
    • 73349115580 scopus 로고    scopus 로고
    • Multicenter, phase I, dose-escalation trial of lenalidomide plus bortezomib for relapsed and relapsed/refractory multiple myeloma
    • Richardson PG, Weller E, Jagannath S, Avigan DE, Alsina M, Schlossman RL et al. Multicenter, phase I, dose-escalation trial of lenalidomide plus bortezomib for relapsed and relapsed/refractory multiple myeloma. J Clin Oncol 2009 27 5713-5719.
    • (2009) J Clin Oncol , vol.27 , pp. 5713-5719
    • Richardson, P.G.1    Weller, E.2    Jagannath, S.3    Avigan, D.E.4    Alsina, M.5    Schlossman, R.L.6
  • 32
    • 79952729549 scopus 로고    scopus 로고
    • Phase II trial of lenalidomide, bortezomib, and dexamethasone in patients (pts) with relapsed and relapsed/refractory multiple Myeloma (MM) updated efficacy and safety data after 42 years of follow-up
    • Richardson PG, Jagannath S, Jakubowiak AJ, Lonial S, Raje N, Alsina M et al. Phase II trial of lenalidomide, bortezomib, and dexamethasone in patients (pts) with relapsed and relapsed/refractory multiple Myeloma (MM) updated efficacy and safety data after 42 years of follow-up. ASH Annu Meet Abstr 2010 116 3049.
    • (2010) ASH Annu Meet Abstr , vol.116 , pp. 3049
    • Richardson, P.G.1    Jagannath, S.2    Jakubowiak, A.J.3    Lonial, S.4    Raje, N.5    Alsina, M.6
  • 33
    • 0343262654 scopus 로고    scopus 로고
    • Crystal structure of epoxomicin20S proteasome reveals a molecular basis for selectivity of a0 ,b0-epoxyketone proteasome inhibitors
    • Groll M, Kim KB, Kairies N, Huber RCC. Crystal structure of epoxomicin20S proteasome reveals a molecular basis for selectivity of a0 ,b0-epoxyketone proteasome inhibitors. J Am Chem Soc 2000 122 1237-1238.
    • (2000) J Am Chem Soc , vol.122 , pp. 1237-1238
    • Groll, M.1    Kim, K.B.2    Kairies, N.3    Huber, R.C.C.4
  • 34
    • 34447116376 scopus 로고    scopus 로고
    • Antitumor activity of PR-171, a novel irreversible inhibitor of the proteasome
    • Demo SD, Kirk CJ, Aujay MA, Buchholz TJ, Dajee M, Ho MN et al. Antitumor activity of PR-171, a novel irreversible inhibitor of the proteasome. Cancer Res 2007 67 6383-6391.
    • (2007) Cancer Res , vol.67 , pp. 6383-6391
    • Demo, S.D.1    Kirk, C.J.2    Aujay, M.A.3    Buchholz, T.J.4    Dajee, M.5    Ho, M.N.6
  • 35
    • 77955712506 scopus 로고    scopus 로고
    • Bortezomib-resistant myeloma cell lines a role for mutated PSMB5 in preventing the accumulation of unfolded proteins and fatal ER stress
    • Ri M, Iida S, Nakashima T, Miyazaki H, Mori F, Ito A et al. Bortezomib-resistant myeloma cell lines a role for mutated PSMB5 in preventing the accumulation of unfolded proteins and fatal ER stress. Leukemia 2010 24 1506-1512.
    • (2010) Leukemia , vol.24 , pp. 1506-1512
    • Ri, M.1    Iida, S.2    Nakashima, T.3    Miyazaki, H.4    Mori, F.5    Ito, A.6
  • 36
    • 54849413402 scopus 로고    scopus 로고
    • Updated survival analyses after prolonged follow-up of the phase 2, multicenter CREST study of bortezomib in relapsed or refractory multiple myeloma
    • Jagannath S, Barlogie B, Berenson JR, Siegel DS, Irwin D, Richardson PG et al. Updated survival analyses after prolonged follow-up of the phase 2, multicenter CREST study of bortezomib in relapsed or refractory multiple myeloma. Br J Haematol 2008 143 537-540.
    • (2008) Br J Haematol , vol.143 , pp. 537-540
    • Jagannath, S.1    Barlogie, B.2    Berenson, J.R.3    Siegel, D.S.4    Irwin, D.5    Richardson, P.G.6
  • 37
    • 78649681350 scopus 로고    scopus 로고
    • Efficacy and safety of once-weekly bortezomib in multiple myeloma patients
    • Bringhen S, Larocca A, Rossi D, Cavalli M, Genuardi M, Ria R et al. Efficacy and safety of once-weekly bortezomib in multiple myeloma patients. Blood 2010 116 4745-4753.
    • (2010) Blood , vol.116 , pp. 4745-4753
    • Bringhen, S.1    Larocca, A.2    Rossi, D.3    Cavalli, M.4    Genuardi, M.5    Ria, R.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.