The relationship of ghrelin and adiponectin with bone mineral density and bone turnover markers in elderly men

Calcified Tissue International

Volumn 83, Issue 1, 2008, Pages 55-60

  Gonnelli, S ^a   Caffarelli, C ^a   Del Santo, K ^a   Cadirni, A ^a   Guerriero, C ^a   Lucani, B ^a   Franci, B ^a   Nuti, R ^a  

^a UNIVERSITY OF SIENA   (Italy)

Author keywords

Adiponectin; Bone mineral density; Bone turnover marker; Fat mass; Ghrelin

Indexed keywords

ADIPONECTIN; ALKALINE PHOSPHATASE BONE ISOENZYME; CARBOXY TERMINAL TELOPEPTIDE; GHRELIN;

ADULT; AGED; ARTICLE; BLOOD LEVEL; BODY COMPOSITION; BODY FAT; BODY MASS; BONE DENSITY; BONE TURNOVER; CALCIUM INTAKE; FAT BODY; FEMUR NECK; HUMAN; HUMAN EXPERIMENT; ITALY; LEAN BODY WEIGHT; MALE; NORMAL HUMAN; PRIORITY JOURNAL; STATISTICAL SIGNIFICANCE;

ABSORPTIOMETRY, PHOTON; ADIPONECTIN; AGED; ALKALINE PHOSPHATASE; BIOLOGICAL MARKERS; BODY COMPOSITION; BODY MASS INDEX; BONE DENSITY; BONE REMODELING; COLLAGEN TYPE I; FEMUR NECK; GHRELIN; HUMANS; MALE; MIDDLE AGED; RADIOIMMUNOASSAY;

EID: 50949091670     PISSN: 0171967X     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00223-008-9149-y     Document Type: Article

References (34)

1. DT Felson Y Zhang MT Hannan JJ Anderson 1993 Effects of weight and body mass index on bone mineral density in men and women: the Framingham Study J Bone Miner Res 8 567 573
2. C De Laet JA Kanis A Odén H Johanson O Johnell P Delmas JA Eisman H Kroger S Fujiwara P Garnero EV McCloskey D Mellstrom LJ Melton 3rd PJ Meunier HA Pols J Reeve A Silman A Tenenhouse 2005 Body mass index as a predictor of fracture risk: a meta-analysis Osteoporos Int 16 1330 1338
3. AE Schindler A Ebert E Friedrich 1972 Conversion of androstenedione to estrone by human tissue J Clin Endocrinol Metab 35 627 630
4. IR Reid 2002 Relationships among body mass, its components, and bone Bone 31 547 555
5. MC Wang LK Bachrach M Van Loan M Hudes KM Flegal PB Crawford 2005 The relative contributions of lean tissue mass and fat mass to bone density in young women Bone 37 474 481
6. S Khosla EJ Atkinson BL Riggs LJ Melton 3rd 1996 Relationship between body composition and bone mass in women J Bone Miner Res 11 857 863
7. LJ Zhao YJ Liu PY Liu J Hamilton RR Recker HW Deng 2007 Relationship of obesity with osteoporosis J Clin Endocrinol Metab 92 1640 1646
8. LJ Zhao H Jiang CJ Papasian D Maulik B Drees J Hamilton HW Deng 2008 Correlation of obesity and osteoporosis-effect of fat mass on the determination of osteoporosis J Bone Miner Res 23 17 29
9. KW Oh WY Lee EJ Rhee KH Baek KH Yoon MI Kang EJ Yun CY Park SH Ihm MG Choi HJ Yoo SW Park 2005 The relationship between serum resistin, leptin, adiponectin, ghrelin levels and bone mineral density in middle-aged men Clin Endocrinol (Oxf) 63 131 138
10. MD Kontogianni UG Dafni JG Routsias FN Skopouli 2004 Blood leptin and adiponectin as possible mediators of the relation between fat mass and BMD in perimenopausal women J Bone Miner Res 19 546 551
11. J Cornish KE Callon U Bava C Lin D Naot BL Hill AB Grey N Broom DE Myers GC Nicholson IR Reid 2002 Leptin directly regulates bone cell function in vitro and reduces bone fragility in vivo J Endocrinol 175 405 415
12. G Martini R Valenti S Giovani B Franci R Campagna R Nuti 2001 Influence of insulin-like growth factor-1 and leptin on bone mass in healthy postmenopausal women Bone 28 113 117
13. JJ Díez P Iglesias 2003 The role of the novel adipocyte-derived hormone adiponectin in human disease Eur J Endocrinol 148 293 300
14. XH Luo LJ Guo LQ Yuan H Xie HD Zhou XP Wu EY Liao 2005 Adiponectin stimulates human osteoblast proliferation and differentiation via the MAPK signaling pathway Exp Cell Res 309 99 109
15. XH Luo LJ Guo H Xie LQ Yuan XP Wu HD Zhou EY Liao 2006 Adiponectin stimulates RANKL and inhibits OPG expression in human osteoblasts through the MAPK signaling pathway J Bone Miner Res 21 1648 1656
16. L Lenchik TC Register FC Hsu K Lohman BJ Nicklas BI Freedman CD Langefeld JJ Carr DW Bowden 2003 Adiponectin as a novel determinant of bone mineral density and visceral fat Bone 33 646 651
17. JB Richards AM Valdes K Burling UC Perks TD Spector 2007 Serum adiponectin and bone mineral density in women J Clin Endocrinol Metab 92 1517 1523
18. J Jürimäe T Jürimäe 2007 Adiponectin is a predictor of bone mineral density in middle-aged premenopausal women Osteoporos Int 18 1253 1259
19. XD Peng H Xie Q Zhao XP Wu ZQ Sun EY Liao 2008 Relationships between serum adiponectin, leptin, resistin, visfatin levels and bone mineral density, and bone biochemical markers in Chinese men Clin Chim Acta 387 31 35
20. NK Lee H Sowa E Hinoi M Ferron JD Ahn C Confavreux R Dacquin PJ Mee MD McKee DY Jung Z Zhang JK Kim F Mauvais-Jarvis P Ducy G Karsenty 2007 Endocrine regulation of energy metabolism by the skeleton Cell 130 456 469
21. M Kojima K Kangawa 2005 Ghrelin: structure and function Physiol Rev 85 495 522
22. J Makovey V Naganathan M Seibel P Sambrook 2007 Gender differences in plasma ghrelin and its relations to body composition and bone-an opposite-sex twin study Clin Endocrinol (Oxf) 66 530 537
23. M van der Velde P Delhanty B van der Eerden AJ van der Lely J van Leeuwen 2008 Ghrelin and bone Vitam Horm 77 239 258
24. N Fukushima R Hanada H Teranishi Y Fukue T Tachibana H Ishikawa S Takeda Y Takeuchi S Fukumoto K Kangawa K Nagata M Kojima 2005 Ghrelin directly regulates bone formation J Bone Miner Res 20 790 798
25. G Maccarinelli V Sibilia A Torsello F Raimondo M Pitto A Giustina C Netti D Cocchi 2005 Ghrelin regulates proliferation and differentiation of osteoblastic cells J Endocrinol 184 249 256
26. SW Kim SJ Her SJ Park D Kim KS Park HK Lee BH Han MS Kim CS Shin SY Kim 2005 Ghrelin stimulates proliferation and differentiation and inhibits apoptosis in osteoblastic MC3T3-E1 cells Bone 37 359 369
27. LA Weiss E Barrett-Connor D von Mühlen P Clark 2006 Leptin predicts BMD and bone resorption in older women but not older men: the Rancho Bernardo Study J Bone Miner Res 21 758 764
28. MS Huda BH Durham SP Wong TM Dovey P McCulloch D Kerrigan JH Pinkney WD Fraser JP Wilding 2007 Lack of an acute effect of ghrelin on markers of bone turnover in healthy controls and post-gastrectomy subjects Bone 41 406 413
29. M Montomoli S Gonnelli M Giacchi R Mattei C Cuda S Rossi C Gennari 2002 Validation of a food frequency questionnaire for nutritional calcium intake assessment in Italian women Eur J Clin Nutr 56 21 30
30. C Dornonville de la Cour A Lindqvist E Egecioglu YC Tung V Surve C Ohlsson JO Jansson C Erlanson-Albertsson SL Dickson R Håkanson 2005 Ghrelin treatment reverses the reduction in weight gain and body fat in gastrectomised mice Gut 54 907 913
31. PS Coates JD Fernstrom MH Fernstrom PR Schauer SL Greenspan 2004 Gastric bypass surgery for morbid obesity leads to an increase in bone turnover and a decrease in bone mass J Clin Endocrinol Metab 89 1061 1065
32. JL Pérez-Castrillón I Justo A Sanz A San Miguel MA Mazón L Abad G Vega A Dueñas 2007 Ghrelin and bone mass in postmenopausal hypertensive women Ann Nutr Metab 51 223 227
33. EF Papakitsou AN Margioris KE Dretakis G Trovas U Zoras G Lyritis EK Dretakis K Stergiopoulos 2004 Body mass index (BMI) and parameters of bone formation and resorption in postmenopausal women Maturitas 47 185 193
34. K Oshima A Nampei M Matsuda M Iwaki A Fukuhara J Hashimoto H Yoshikawa I Shimomura 2005 Adiponectin increases bone mass by suppressing osteoclast and activating osteoblast Biochem Biophys Res Commun 331 520 526