메뉴 건너뛰기




Volumn 6, Issue APR, 2016, Pages

Cytokine-induced modulation of colorectal cancer

Author keywords

Biomarker; Colorectal cancer; Cytokine; Inflammation; Tumor microenvironment

Indexed keywords

GAMMA INTERFERON; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INFLAMMASOME; INTERLEUKIN 1; INTERLEUKIN 10; INTERLEUKIN 11; INTERLEUKIN 15; INTERLEUKIN 17; INTERLEUKIN 18; INTERLEUKIN 21; INTERLEUKIN 22; INTERLEUKIN 23; INTERLEUKIN 4; INTERLEUKIN 6; INTERLEUKIN 8; INTERLEUKIN 9; STAT6 PROTEIN; TRANSFORMING GROWTH FACTOR BETA; TUMOR NECROSIS FACTOR; VASCULOTROPIN;

EID: 84973526853     PISSN: None     EISSN: 2234943X     Source Type: Journal    
DOI: 10.3389/fonc.2016.00096     Document Type: Review
Times cited : (185)

References (306)
  • 1
    • 78049485263 scopus 로고    scopus 로고
    • Estimates of worldwide burden of cancer in 2008: GLOBOCAN 2008
    • Ferlay J, Shin HR, Bray F, Forman D, Mathers C, Parkin DM. Estimates of worldwide burden of cancer in 2008: GLOBOCAN 2008. Int J Cancer (2010) 127:2893-917. doi:10.1002/ijc.25516
    • (2010) Int J Cancer , vol.127 , pp. 2893-2917
    • Ferlay, J.1    Shin, H.R.2    Bray, F.3    Forman, D.4    Mathers, C.5    Parkin, D.M.6
  • 2
    • 84941364888 scopus 로고    scopus 로고
    • Genetic architecture of colorectal cancer
    • Peters U, Bien S, Zubair N. Genetic architecture of colorectal cancer. Gut (2015) 64:1623-36. doi:10.1136/gutjnl-2013-306705
    • (2015) Gut , vol.64 , pp. 1623-1636
    • Peters, U.1    Bien, S.2    Zubair, N.3
  • 3
    • 4944240144 scopus 로고    scopus 로고
    • Genetic predisposition to colorectal cancer
    • de la Chapelle A. Genetic predisposition to colorectal cancer. Nat Rev Cancer (2004) 4:769-80. doi:10.1038/nrc1453
    • (2004) Nat Rev Cancer , vol.4 , pp. 769-780
    • de la Chapelle, A.1
  • 4
    • 80052049486 scopus 로고    scopus 로고
    • Molecular genetic analysis of 103 sporadic colorectal tumours in Czech patients
    • Vasovcak P, Pavlikova K, Sedlacek Z, Skapa P, Kouda M, Hoch J, et al. Molecular genetic analysis of 103 sporadic colorectal tumours in Czech patients. PLoS One (2011) 6:e24114. doi:10.1371/journal.pone.0024114
    • (2011) PLoS One , vol.6
    • Vasovcak, P.1    Pavlikova, K.2    Sedlacek, Z.3    Skapa, P.4    Kouda, M.5    Hoch, J.6
  • 5
    • 84890472864 scopus 로고    scopus 로고
    • Molecular pathways involved in colorectal cancer: implications for disease behavior and prevention
    • Colussi D, Brandi G, Bazzoli F, Ricciardiello L. Molecular pathways involved in colorectal cancer: implications for disease behavior and prevention. Int J Mol Sci (2013) 14:16365-85. doi:10.3390/ijms140816365
    • (2013) Int J Mol Sci , vol.14 , pp. 16365-16385
    • Colussi, D.1    Brandi, G.2    Bazzoli, F.3    Ricciardiello, L.4
  • 6
    • 78649639011 scopus 로고    scopus 로고
    • The tumor microenvironment in colorectal carcinogenesis
    • Peddareddigari VG, Wang D, Dubois RN. The tumor microenvironment in colorectal carcinogenesis. Cancer Microenviron (2010) 3:149-66. doi:10.1007/s12307-010-0038-3
    • (2010) Cancer Microenviron , vol.3 , pp. 149-166
    • Peddareddigari, V.G.1    Wang, D.2    Dubois, R.N.3
  • 7
    • 84869021181 scopus 로고    scopus 로고
    • Dependency of colorectal cancer on a TGF-beta-driven program in stromal cells for metastasis initiation
    • Calon A, Espinet E, Palomo-Ponce S, Tauriello DV, Iglesias M, Cespedes MV, et al. Dependency of colorectal cancer on a TGF-beta-driven program in stromal cells for metastasis initiation. Cancer Cell (2012) 22:571-84. doi:10.1016/j.ccr.2012.08.013
    • (2012) Cancer Cell , vol.22 , pp. 571-584
    • Calon, A.1    Espinet, E.2    Palomo-Ponce, S.3    Tauriello, D.V.4    Iglesias, M.5    Cespedes, M.V.6
  • 8
    • 84873728505 scopus 로고    scopus 로고
    • Endothelial cells promote the colorectal cancer stem cell phenotype through a soluble form of Jagged-1
    • Lu J, Ye X, Fan F, Xia L, Bhattacharya R, Bellister S, et al. Endothelial cells promote the colorectal cancer stem cell phenotype through a soluble form of Jagged-1. Cancer Cell (2013) 23:171-85. doi:10.1016/j.ccr.2012.12.021
    • (2013) Cancer Cell , vol.23 , pp. 171-185
    • Lu, J.1    Ye, X.2    Fan, F.3    Xia, L.4    Bhattacharya, R.5    Bellister, S.6
  • 10
    • 0022453271 scopus 로고
    • The grading of rectal cancer: historical perspectives and a multivariate analysis of 447 cases
    • Jass JR, Atkin WS, Cuzick J, Bussey HJ, Morson BC, Northover JM, et al. The grading of rectal cancer: historical perspectives and a multivariate analysis of 447 cases. Histopathology (1986) 10:437-59. doi:10.1111/j.1365-2559.1986.tb02497.x
    • (1986) Histopathology , vol.10 , pp. 437-459
    • Jass, J.R.1    Atkin, W.S.2    Cuzick, J.3    Bussey, H.J.4    Morson, B.C.5    Northover, J.M.6
  • 12
    • 33749319703 scopus 로고    scopus 로고
    • Type, density, and location of immune cells within human colorectal tumors predict clinical outcome
    • Galon J, Costes A, Sanchez-Cabo F, Kirilovsky A, Mlecnik B, Lagorce-Pages C, et al. Type, density, and location of immune cells within human colorectal tumors predict clinical outcome. Science (2006) 313:1960-4. doi:10.1126/science.1129139
    • (2006) Science , vol.313 , pp. 1960-1964
    • Galon, J.1    Costes, A.2    Sanchez-Cabo, F.3    Kirilovsky, A.4    Mlecnik, B.5    Lagorce-Pages, C.6
  • 13
    • 84866852663 scopus 로고    scopus 로고
    • Cancer classification using the Immunoscore: a worldwide task force
    • Galon J, Pages F, Marincola FM, Angell HK, Thurin M, Lugli A, et al. Cancer classification using the Immunoscore: a worldwide task force. J Transl Med (2012) 10:205. doi:10.1186/1479-5876-10-205
    • (2012) J Transl Med , vol.10 , pp. 205
    • Galon, J.1    Pages, F.2    Marincola, F.M.3    Angell, H.K.4    Thurin, M.5    Lugli, A.6
  • 14
    • 84890280907 scopus 로고    scopus 로고
    • Towards the introduction of the 'Immunoscore' in the classification of malignant tumours
    • Galon J, Mlecnik B, Bindea G, Angell HK, Berger A, Lagorce C, et al. Towards the introduction of the 'Immunoscore' in the classification of malignant tumours. J Pathol (2014) 232:199-209. doi:10.1002/path.4287
    • (2014) J Pathol , vol.232 , pp. 199-209
    • Galon, J.1    Mlecnik, B.2    Bindea, G.3    Angell, H.K.4    Berger, A.5    Lagorce, C.6
  • 15
    • 79951815749 scopus 로고    scopus 로고
    • Clinical impact of different classes of infiltrating T cytotoxic and helper cells (Th1, Th2, Treg, Th17) in patients with colorectal cancer
    • Tosolini M, Kirilovsky A, Mlecnik B, Fredriksen T, Mauger S, Bindea G, et al. Clinical impact of different classes of infiltrating T cytotoxic and helper cells (Th1, Th2, Treg, Th17) in patients with colorectal cancer. Cancer Res (2011) 71:1263-71. doi:10.1158/0008-5472.CAN-10-2907
    • (2011) Cancer Res , vol.71 , pp. 1263-1271
    • Tosolini, M.1    Kirilovsky, A.2    Mlecnik, B.3    Fredriksen, T.4    Mauger, S.5    Bindea, G.6
  • 16
    • 84869096388 scopus 로고    scopus 로고
    • Stage-dependent alterations of the serum cytokine pattern in colorectal carcinoma
    • Kantola T, Klintrup K, Vayrynen JP, Vornanen J, Bloigu R, Karhu T, et al. Stage-dependent alterations of the serum cytokine pattern in colorectal carcinoma. Br J Cancer (2012) 107:1729-36. doi:10.1038/bjc.2012.456
    • (2012) Br J Cancer , vol.107 , pp. 1729-1736
    • Kantola, T.1    Klintrup, K.2    Vayrynen, J.P.3    Vornanen, J.4    Bloigu, R.5    Karhu, T.6
  • 17
    • 84894596899 scopus 로고    scopus 로고
    • Role of T17 cytokines in the control of colorectal cancer
    • De Simone V, Pallone F, Monteleone G, Stolfi C. Role of T17 cytokines in the control of colorectal cancer. Oncoimmunology (2013) 2:e26617. doi:10.4161/onci.26617
    • (2013) Oncoimmunology , vol.2
    • De Simone, V.1    Pallone, F.2    Monteleone, G.3    Stolfi, C.4
  • 18
    • 84880037004 scopus 로고    scopus 로고
    • Profiles of circulating inflammatory cytokines in colorectal cancer (CRC), high cancer risk conditions, and health are distinct. Possible implications for CRC screening and surveillance
    • Krzystek-Korpacka M, Diakowska D, Kapturkiewicz B, Bebenek M, Gamian A. Profiles of circulating inflammatory cytokines in colorectal cancer (CRC), high cancer risk conditions, and health are distinct. Possible implications for CRC screening and surveillance. Cancer Lett (2013) 337:107-14. doi:10.1016/j.canlet.2013.05.033
    • (2013) Cancer Lett , vol.337 , pp. 107-114
    • Krzystek-Korpacka, M.1    Diakowska, D.2    Kapturkiewicz, B.3    Bebenek, M.4    Gamian, A.5
  • 19
    • 84899050715 scopus 로고    scopus 로고
    • Functional network pipeline reveals genetic determinants associated with in situ lymphocyte proliferation and survival of cancer patients
    • Mlecnik B, Bindea G, Angell HK, Sasso MS, Obenauf AC, Fredriksen T, et al. Functional network pipeline reveals genetic determinants associated with in situ lymphocyte proliferation and survival of cancer patients. Sci Transl Med (2014) 6:228ra237. doi:10.1126/scitranslmed.3007240
    • (2014) Sci Transl Med , vol.6
    • Mlecnik, B.1    Bindea, G.2    Angell, H.K.3    Sasso, M.S.4    Obenauf, A.C.5    Fredriksen, T.6
  • 20
    • 84922132326 scopus 로고    scopus 로고
    • Tumor-specific cytotoxic T lymphocyte activity determines colorectal cancer patient prognosis
    • Reissfelder C, Stamova S, Gossmann C, Braun M, Bonertz A, Walliczek U, et al. Tumor-specific cytotoxic T lymphocyte activity determines colorectal cancer patient prognosis. J Clin Invest (2015) 125:739-51. doi:10.1172/JCI74894
    • (2015) J Clin Invest , vol.125 , pp. 739-751
    • Reissfelder, C.1    Stamova, S.2    Gossmann, C.3    Braun, M.4    Bonertz, A.5    Walliczek, U.6
  • 21
    • 84868613705 scopus 로고    scopus 로고
    • Adenoma-linked barrier defects and microbial products drive IL-23/IL-17-mediated tumour growth
    • Grivennikov SI, Wang K, Mucida D, Stewart CA, Schnabl B, Jauch D, et al. Adenoma-linked barrier defects and microbial products drive IL-23/IL-17-mediated tumour growth. Nature (2012) 491:254-8. doi:10.1038/nature11465
    • (2012) Nature , vol.491 , pp. 254-258
    • Grivennikov, S.I.1    Wang, K.2    Mucida, D.3    Stewart, C.A.4    Schnabl, B.5    Jauch, D.6
  • 23
    • 33644829173 scopus 로고    scopus 로고
    • Interleukin-1 receptor antagonist gene polymorphism in human colorectal cancer
    • Viet HT, Wagsater D, Hugander A, Dimberg J. Interleukin-1 receptor antagonist gene polymorphism in human colorectal cancer. Oncol Rep (2005) 14:915-8. doi:10.3892/or.14.4.915
    • (2005) Oncol Rep , vol.14 , pp. 915-918
    • Viet, H.T.1    Wagsater, D.2    Hugander, A.3    Dimberg, J.4
  • 24
    • 84899631135 scopus 로고    scopus 로고
    • Neutrophil infiltration favors colitis-associated tumorigenesis by activating the interleukin-1 (IL-1)/IL-6 axis
    • Wang Y, Wang K, Han GC, Wang RX, Xiao H, Hou CM, et al. Neutrophil infiltration favors colitis-associated tumorigenesis by activating the interleukin-1 (IL-1)/IL-6 axis. Mucosal Immunol (2014) 7:1106-15. doi:10.1038/mi.2013.126
    • (2014) Mucosal Immunol , vol.7 , pp. 1106-1115
    • Wang, Y.1    Wang, K.2    Han, G.C.3    Wang, R.X.4    Xiao, H.5    Hou, C.M.6
  • 25
    • 70449105185 scopus 로고    scopus 로고
    • Macrophage-derived IL-1beta stimulates Wnt signaling and growth of colon cancer cells: a crosstalk interrupted by vitamin D3
    • Kaler P, Augenlicht L, Klampfer L. Macrophage-derived IL-1beta stimulates Wnt signaling and growth of colon cancer cells: a crosstalk interrupted by vitamin D3. Oncogene (2009) 28:3892-902. doi:10.1038/onc.2009.247
    • (2009) Oncogene , vol.28 , pp. 3892-3902
    • Kaler, P.1    Augenlicht, L.2    Klampfer, L.3
  • 26
    • 35448954376 scopus 로고    scopus 로고
    • Reduced inflammation in the tumor microenvironment delays the accumulation of myeloid-derived suppressor cells and limits tumor progression
    • Bunt SK, Yang L, Sinha P, Clements VK, Leips J, Ostrand-Rosenberg S. Reduced inflammation in the tumor microenvironment delays the accumulation of myeloid-derived suppressor cells and limits tumor progression. Cancer Res (2007) 67:10019-26. doi:10.1158/0008-5472.CAN-07-2354
    • (2007) Cancer Res , vol.67 , pp. 10019-10026
    • Bunt, S.K.1    Yang, L.2    Sinha, P.3    Clements, V.K.4    Leips, J.5    Ostrand-Rosenberg, S.6
  • 27
    • 54549089856 scopus 로고    scopus 로고
    • Overexpression of interleukin-1beta induces gastric inflammation and cancer and mobilizes myeloid-derived suppressor cells in mice
    • Tu S, Bhagat G, Cui G, Takaishi S, Kurt-Jones EA, Rickman B, et al. Overexpression of interleukin-1beta induces gastric inflammation and cancer and mobilizes myeloid-derived suppressor cells in mice. Cancer Cell (2008) 14:408-19. doi:10.1016/j.ccr.2008.10.011
    • (2008) Cancer Cell , vol.14 , pp. 408-419
    • Tu, S.1    Bhagat, G.2    Cui, G.3    Takaishi, S.4    Kurt-Jones, E.A.5    Rickman, B.6
  • 28
    • 29644442445 scopus 로고    scopus 로고
    • Inflammation induces myeloid-derived suppressor cells that facilitate tumor progression
    • Bunt SK, Sinha P, Clements VK, Leips J, Ostrand-Rosenberg S. Inflammation induces myeloid-derived suppressor cells that facilitate tumor progression. J Immunol (2006) 176:284-90. doi:10.4049/jimmunol.176.1.284
    • (2006) J Immunol , vol.176 , pp. 284-290
    • Bunt, S.K.1    Sinha, P.2    Clements, V.K.3    Leips, J.4    Ostrand-Rosenberg, S.5
  • 29
    • 65449155181 scopus 로고    scopus 로고
    • IL-1alpha secreted by colon cancer cells enhances angiogenesis: the relationship between IL-1alpha release and tumor cells' potential for liver metastasis
    • Matsuo Y, Sawai H, Ma J, Xu D, Ochi N, Yasuda A, et al. IL-1alpha secreted by colon cancer cells enhances angiogenesis: the relationship between IL-1alpha release and tumor cells' potential for liver metastasis. J Surg Oncol (2009) 99:361-7. doi:10.1002/jso.21245
    • (2009) J Surg Oncol , vol.99 , pp. 361-367
    • Matsuo, Y.1    Sawai, H.2    Ma, J.3    Xu, D.4    Ochi, N.5    Yasuda, A.6
  • 30
    • 47249089097 scopus 로고    scopus 로고
    • IL-1, IL-18, and IL-33 families of cytokines
    • Arend WP, Palmer G, Gabay C. IL-1, IL-18, and IL-33 families of cytokines. Immunol Rev (2008) 223:20-38. doi:10.1111/j.1600-065X.2008.00624.x
    • (2008) Immunol Rev , vol.223 , pp. 20-38
    • Arend, W.P.1    Palmer, G.2    Gabay, C.3
  • 31
    • 67749117934 scopus 로고    scopus 로고
    • Signal integration by JNK and p38 MAPK pathways in cancer development
    • Wagner EF, Nebreda AR. Signal integration by JNK and p38 MAPK pathways in cancer development. Nat Rev Cancer (2009) 9:537-49. doi:10.1038/nrc2694
    • (2009) Nat Rev Cancer , vol.9 , pp. 537-549
    • Wagner, E.F.1    Nebreda, A.R.2
  • 32
    • 77549083560 scopus 로고    scopus 로고
    • Dangerous liaisons: STAT3 and NF-kappaB collaboration and crosstalk in cancer
    • Grivennikov SI, Karin M. Dangerous liaisons: STAT3 and NF-kappaB collaboration and crosstalk in cancer. Cytokine Growth Factor Rev (2010) 21:11-9. doi:10.1016/j.cytogfr.2009.11.005
    • (2010) Cytokine Growth Factor Rev , vol.21 , pp. 11-19
    • Grivennikov, S.I.1    Karin, M.2
  • 33
    • 84861986053 scopus 로고    scopus 로고
    • Wnt/beta-catenin signaling and disease
    • Clevers H, Nusse R. Wnt/beta-catenin signaling and disease. Cell (2012) 149:1192-205. doi:10.1016/j.cell.2012.05.012
    • (2012) Cell , vol.149 , pp. 1192-1205
    • Clevers, H.1    Nusse, R.2
  • 34
    • 84873810224 scopus 로고    scopus 로고
    • Impact of COX-2, IL-1beta, TNF-alpha, IL-4 and IL-10 on the process of carcinogenesis in the large bowel
    • Marszalek A, Szylberg L, Wisniewska E, Janiczek M. Impact of COX-2, IL-1beta, TNF-alpha, IL-4 and IL-10 on the process of carcinogenesis in the large bowel. Pol J Pathol (2012) 63:221-7. doi:10.5114/pjp.2012.32768
    • (2012) Pol J Pathol , vol.63 , pp. 221-227
    • Marszalek, A.1    Szylberg, L.2    Wisniewska, E.3    Janiczek, M.4
  • 36
    • 77953943322 scopus 로고    scopus 로고
    • Epithelial interleukin-4 receptor expression promotes colon tumor growth
    • Koller FL, Hwang DG, Dozier EA, Fingleton B. Epithelial interleukin-4 receptor expression promotes colon tumor growth. Carcinogenesis (2010) 31:1010-7. doi:10.1093/carcin/bgq044
    • (2010) Carcinogenesis , vol.31 , pp. 1010-1017
    • Koller, F.L.1    Hwang, D.G.2    Dozier, E.A.3    Fingleton, B.4
  • 37
    • 84885140762 scopus 로고    scopus 로고
    • Reduced type II interleukin-4 receptor signalling drives initiation, but not progression, of colorectal carcinogenesis: evidence from transgenic mouse models and human case-control epidemiological observations
    • Ingram N, Northwood EL, Perry SL, Marston G, Snowden H, Taylor JC, et al. Reduced type II interleukin-4 receptor signalling drives initiation, but not progression, of colorectal carcinogenesis: evidence from transgenic mouse models and human case-control epidemiological observations. Carcinogenesis (2013) 34:2341-9. doi:10.1093/carcin/bgt222
    • (2013) Carcinogenesis , vol.34 , pp. 2341-2349
    • Ingram, N.1    Northwood, E.L.2    Perry, S.L.3    Marston, G.4    Snowden, H.5    Taylor, J.C.6
  • 38
    • 79955413653 scopus 로고    scopus 로고
    • Tumor-reactive CD4+ CD8alphabeta+ CD103+ alphabetaT cells: a prevalent tumor-reactive T-cell subset in metastatic colorectal cancers
    • Sarrabayrouse G, Corvaisier M, Ouisse LH, Bossard C, Le Mevel B, Potiron L, et al. Tumor-reactive CD4+ CD8alphabeta+ CD103+ alphabetaT cells: a prevalent tumor-reactive T-cell subset in metastatic colorectal cancers. Int J Cancer (2011) 128:2923-32. doi:10.1002/ijc.25640
    • (2011) Int J Cancer , vol.128 , pp. 2923-2932
    • Sarrabayrouse, G.1    Corvaisier, M.2    Ouisse, L.H.3    Bossard, C.4    Le Mevel, B.5    Potiron, L.6
  • 39
    • 84891121499 scopus 로고    scopus 로고
    • Cancer-initiating cells from colorectal cancer patients escape from T cell-mediated immunosurveillance in vitro through membrane-bound IL-4
    • Volonte A, Di Tomaso T, Spinelli M, Todaro M, Sanvito F, Albarello L, et al. Cancer-initiating cells from colorectal cancer patients escape from T cell-mediated immunosurveillance in vitro through membrane-bound IL-4. J Immunol (2014) 192:523-32. doi:10.4049/jimmunol.1301342
    • (2014) J Immunol , vol.192 , pp. 523-532
    • Volonte, A.1    Di Tomaso, T.2    Spinelli, M.3    Todaro, M.4    Sanvito, F.5    Albarello, L.6
  • 40
    • 0033010373 scopus 로고    scopus 로고
    • The IL-4 receptor: signaling mechanisms and biologic functions
    • Nelms K, Keegan AD, Zamorano J, Ryan JJ, Paul WE. The IL-4 receptor: signaling mechanisms and biologic functions. Annu Rev Immunol (1999) 17:701-38. doi:10.1146/annurev.immunol.17.1.701
    • (1999) Annu Rev Immunol , vol.17 , pp. 701-738
    • Nelms, K.1    Keegan, A.D.2    Zamorano, J.3    Ryan, J.J.4    Paul, W.E.5
  • 41
    • 0034496016 scopus 로고    scopus 로고
    • IL-4 induces serine phosphorylation of the STAT6 transactivation domain in B lymphocytes
    • Wick KR, Berton MT. IL-4 induces serine phosphorylation of the STAT6 transactivation domain in B lymphocytes. Mol Immunol (2000) 37:641-52. doi:10.1016/S0161-5890(00)00088-2
    • (2000) Mol Immunol , vol.37 , pp. 641-652
    • Wick, K.R.1    Berton, M.T.2
  • 42
    • 34548165283 scopus 로고    scopus 로고
    • The IL-4/IL-13/Stat6 signalling pathway promotes luminal mammary epithelial cell development
    • Khaled WT, Read EK, Nicholson SE, Baxter FO, Brennan AJ, Came PJ, et al. The IL-4/IL-13/Stat6 signalling pathway promotes luminal mammary epithelial cell development. Development (2007) 134:2739-50. doi:10.1242/dev.003194
    • (2007) Development , vol.134 , pp. 2739-2750
    • Khaled, W.T.1    Read, E.K.2    Nicholson, S.E.3    Baxter, F.O.4    Brennan, A.J.5    Came, P.J.6
  • 43
    • 77953176278 scopus 로고    scopus 로고
    • EZH2 and STAT6 expression profiles are correlated with colorectal cancer stage and prognosis
    • Wang CG, Ye YJ, Yuan J, Liu FF, Zhang H, Wang S. EZH2 and STAT6 expression profiles are correlated with colorectal cancer stage and prognosis. World J Gastroenterol (2010) 16:2421-7. doi:10.3748/wjg.v16.i19.2421
    • (2010) World J Gastroenterol , vol.16 , pp. 2421-2427
    • Wang, C.G.1    Ye, Y.J.2    Yuan, J.3    Liu, F.F.4    Zhang, H.5    Wang, S.6
  • 44
    • 0026331269 scopus 로고
    • Treatment of established renal cancer by tumor cells engineered to secrete interleukin-4
    • Golumbek PT, Lazenby AJ, Levitsky HI, Jaffee LM, Karasuyama H, Baker M, et al. Treatment of established renal cancer by tumor cells engineered to secrete interleukin-4. Science (1991) 254:713-6. doi:10.1126/science.1948050
    • (1991) Science , vol.254 , pp. 713-716
    • Golumbek, P.T.1    Lazenby, A.J.2    Levitsky, H.I.3    Jaffee, L.M.4    Karasuyama, H.5    Baker, M.6
  • 46
    • 0026657391 scopus 로고
    • An eosinophil-dependent mechanism for the antitumor effect of interleukin-4
    • Tepper RI, Coffman RL, Leder P. An eosinophil-dependent mechanism for the antitumor effect of interleukin-4. Science (1992) 257:548-51. doi:10.1126/science.1636093
    • (1992) Science , vol.257 , pp. 548-551
    • Tepper, R.I.1    Coffman, R.L.2    Leder, P.3
  • 47
    • 84869758362 scopus 로고    scopus 로고
    • Interleukin-6-a key regulator of colorectal cancer development
    • Waldner MJ, Foersch S, Neurath MF. Interleukin-6-a key regulator of colorectal cancer development. Int J Biol Sci (2012) 8:1248-53. doi:10.7150/ijbs.4614
    • (2012) Int J Biol Sci , vol.8 , pp. 1248-1253
    • Waldner, M.J.1    Foersch, S.2    Neurath, M.F.3
  • 49
    • 0038393312 scopus 로고    scopus 로고
    • Expression of cyclooxygenase-2 parallels expression of interleukin-1beta, interleukin-6 and NF-kappaB in human colorectal cancer
    • Maihofner C, Charalambous MP, Bhambra U, Lightfoot T, Geisslinger G, Gooderham NJ, et al. Expression of cyclooxygenase-2 parallels expression of interleukin-1beta, interleukin-6 and NF-kappaB in human colorectal cancer. Carcinogenesis (2003) 24:665-71. doi:10.1093/carcin/bgg006
    • (2003) Carcinogenesis , vol.24 , pp. 665-671
    • Maihofner, C.1    Charalambous, M.P.2    Bhambra, U.3    Lightfoot, T.4    Geisslinger, G.5    Gooderham, N.J.6
  • 50
    • 0042209597 scopus 로고    scopus 로고
    • Serum interleukin-6 levels reflect the disease status of colorectal cancer
    • Chung YC, Chang YF. Serum interleukin-6 levels reflect the disease status of colorectal cancer. J Surg Oncol (2003) 83:222-6. doi:10.1002/jso.10269
    • (2003) J Surg Oncol , vol.83 , pp. 222-226
    • Chung, Y.C.1    Chang, Y.F.2
  • 51
    • 0034106055 scopus 로고    scopus 로고
    • Interleukin-6 blood level is associated with circulating carcinoembryonic antigen and prognosis in patients with colorectal cancer
    • Belluco C, Nitti D, Frantz M, Toppan P, Basso D, Plebani M, et al. Interleukin-6 blood level is associated with circulating carcinoembryonic antigen and prognosis in patients with colorectal cancer. Ann Surg Oncol (2000) 7:133-8. doi:10.1007/s10434-000-0133-7
    • (2000) Ann Surg Oncol , vol.7 , pp. 133-138
    • Belluco, C.1    Nitti, D.2    Frantz, M.3    Toppan, P.4    Basso, D.5    Plebani, M.6
  • 52
    • 0032807379 scopus 로고    scopus 로고
    • Elevated serum thrombopoietin and interleukin-6 concentrations in thrombocytosis associated with inflammatory bowel disease
    • Heits F, Stahl M, Ludwig D, Stange EF, Jelkmann W. Elevated serum thrombopoietin and interleukin-6 concentrations in thrombocytosis associated with inflammatory bowel disease. J Interferon Cytokine Res (1999) 19:757-60. doi:10.1089/107999099313604
    • (1999) J Interferon Cytokine Res , vol.19 , pp. 757-760
    • Heits, F.1    Stahl, M.2    Ludwig, D.3    Stange, E.F.4    Jelkmann, W.5
  • 53
    • 18344410191 scopus 로고    scopus 로고
    • Blockade of interleukin 6 trans signaling suppresses T-cell resistance against apoptosis in chronic intestinal inflammation: evidence in crohn disease and experimental colitis in vivo
    • Atreya R, Mudter J, Finotto S, Mullberg J, Jostock T, Wirtz S, et al. Blockade of interleukin 6 trans signaling suppresses T-cell resistance against apoptosis in chronic intestinal inflammation: evidence in crohn disease and experimental colitis in vivo. Nat Med (2000) 6:583-8. doi:10.1038/75068
    • (2000) Nat Med , vol.6 , pp. 583-588
    • Atreya, R.1    Mudter, J.2    Finotto, S.3    Mullberg, J.4    Jostock, T.5    Wirtz, S.6
  • 54
    • 5644252874 scopus 로고    scopus 로고
    • TGF-beta suppresses tumor progression in colon cancer by inhibition of IL-6 trans-signaling
    • Becker C, Fantini MC, Schramm C, Lehr HA, Wirtz S, Nikolaev A, et al. TGF-beta suppresses tumor progression in colon cancer by inhibition of IL-6 trans-signaling. Immunity (2004) 21:491-501. doi:10.1016/j.immuni.2004.07.020
    • (2004) Immunity , vol.21 , pp. 491-501
    • Becker, C.1    Fantini, M.C.2    Schramm, C.3    Lehr, H.A.4    Wirtz, S.5    Nikolaev, A.6
  • 55
    • 58649108302 scopus 로고    scopus 로고
    • IL-6 and Stat3 are required for survival of intestinal epithelial cells and development of colitis-associated cancer
    • Grivennikov S, Karin E, Terzic J, Mucida D, Yu GY, Vallabhapurapu S, et al. IL-6 and Stat3 are required for survival of intestinal epithelial cells and development of colitis-associated cancer. Cancer Cell (2009) 15:103-13. doi:10.1016/j.ccr.2009.01.001
    • (2009) Cancer Cell , vol.15 , pp. 103-113
    • Grivennikov, S.1    Karin, E.2    Terzic, J.3    Mucida, D.4    Yu, G.Y.5    Vallabhapurapu, S.6
  • 56
    • 84892917277 scopus 로고    scopus 로고
    • Interleukin-6 released by colon cancer-associated fibroblasts is critical for tumour angiogenesis: anti-interleukin-6 receptor antibody suppressed angiogenesis and inhibited tumour-stroma interaction
    • Nagasaki T, Hara M, Nakanishi H, Takahashi H, Sato M, Takeyama H. Interleukin-6 released by colon cancer-associated fibroblasts is critical for tumour angiogenesis: anti-interleukin-6 receptor antibody suppressed angiogenesis and inhibited tumour-stroma interaction. Br J Cancer (2014) 110:469-78. doi:10.1038/bjc.2013.748
    • (2014) Br J Cancer , vol.110 , pp. 469-478
    • Nagasaki, T.1    Hara, M.2    Nakanishi, H.3    Takahashi, H.4    Sato, M.5    Takeyama, H.6
  • 57
    • 84900841536 scopus 로고    scopus 로고
    • Tumor-associated macrophage-derived IL-6 and IL-8 enhance invasive activity of LoVo cells induced by PRL-3 in a KCNN4 channel-dependent manner
    • Xu H, Lai W, Zhang Y, Liu L, Luo X, Zeng Y, et al. Tumor-associated macrophage-derived IL-6 and IL-8 enhance invasive activity of LoVo cells induced by PRL-3 in a KCNN4 channel-dependent manner. BMC Cancer (2014) 14:330. doi:10.1186/1471-2407-14-330
    • (2014) BMC Cancer , vol.14 , pp. 330
    • Xu, H.1    Lai, W.2    Zhang, Y.3    Liu, L.4    Luo, X.5    Zeng, Y.6
  • 58
    • 84924069554 scopus 로고    scopus 로고
    • Interleukin 6 alters localization of hMSH3, leading to DNA mismatch repair defects in colorectal cancer cells
    • Tseng-Rogenski SS, Hamaya Y, Choi DY, Carethers JM. Interleukin 6 alters localization of hMSH3, leading to DNA mismatch repair defects in colorectal cancer cells. Gastroenterology (2015) 148:579-89. doi:10.1053/j.gastro.2014.11.027
    • (2015) Gastroenterology , vol.148 , pp. 579-589
    • Tseng-Rogenski, S.S.1    Hamaya, Y.2    Choi, D.Y.3    Carethers, J.M.4
  • 59
    • 84887530424 scopus 로고    scopus 로고
    • Myeloid-derived suppressor cells attenuate TH1 development through IL-6 production to promote tumor progression
    • Tsukamoto H, Nishikata R, Senju S, Nishimura Y. Myeloid-derived suppressor cells attenuate TH1 development through IL-6 production to promote tumor progression. Cancer Immunol Res (2013) 1:64-76. doi:10.1158/2326-6066.CIR-13-0030
    • (2013) Cancer Immunol Res , vol.1 , pp. 64-76
    • Tsukamoto, H.1    Nishikata, R.2    Senju, S.3    Nishimura, Y.4
  • 60
    • 84869797922 scopus 로고    scopus 로고
    • IL-6 trans-signaling via the soluble IL-6 receptor: importance for the pro-inflammatory activities of IL-6
    • Rose-John S. IL-6 trans-signaling via the soluble IL-6 receptor: importance for the pro-inflammatory activities of IL-6. Int J Biol Sci (2012) 8:1237-47. doi:10.7150/ijbs.4989
    • (2012) Int J Biol Sci , vol.8 , pp. 1237-1247
    • Rose-John, S.1
  • 61
    • 22044437986 scopus 로고    scopus 로고
    • Persistent STAT3 activation in colon cancer is associated with enhanced cell proliferation and tumor growth
    • Corvinus FM, Orth C, Moriggl R, Tsareva SA, Wagner S, Pfitzner EB, et al. Persistent STAT3 activation in colon cancer is associated with enhanced cell proliferation and tumor growth. Neoplasia (2005) 7:545-55. doi:10.1593/neo.04571
    • (2005) Neoplasia , vol.7 , pp. 545-555
    • Corvinus, F.M.1    Orth, C.2    Moriggl, R.3    Tsareva, S.A.4    Wagner, S.5    Pfitzner, E.B.6
  • 62
    • 33847406439 scopus 로고    scopus 로고
    • Activation of STAT3 is a marker of poor prognosis in human colorectal cancer
    • Kusaba T, Nakayama T, Yamazumi K, Yakata Y, Yoshizaki A, Inoue K, et al. Activation of STAT3 is a marker of poor prognosis in human colorectal cancer. Oncol Rep (2006) 15:1445-51. doi:10.3892/or.15.6.1445
    • (2006) Oncol Rep , vol.15 , pp. 1445-1451
    • Kusaba, T.1    Nakayama, T.2    Yamazumi, K.3    Yakata, Y.4    Yoshizaki, A.5    Inoue, K.6
  • 63
    • 79952715805 scopus 로고    scopus 로고
    • STAT3 expression, molecular features, inflammation patterns, and prognosis in a database of 724 colorectal cancers
    • Morikawa T, Baba Y, Yamauchi M, Kuchiba A, Nosho K, Shima K, et al. STAT3 expression, molecular features, inflammation patterns, and prognosis in a database of 724 colorectal cancers. Clin Cancer Res (2011) 17:1452-62. doi:10.1158/1078-0432.CCR-10-2694
    • (2011) Clin Cancer Res , vol.17 , pp. 1452-1462
    • Morikawa, T.1    Baba, Y.2    Yamauchi, M.3    Kuchiba, A.4    Nosho, K.5    Shima, K.6
  • 64
    • 84871320421 scopus 로고    scopus 로고
    • Mice that express human interleukin-8 have increased mobilization of immature myeloid cells, which exacerbates inflammation and accelerates colon carcinogenesis
    • Asfaha S, Dubeykovskiy AN, Tomita H, Yang X, Stokes S, Shibata W, et al. Mice that express human interleukin-8 have increased mobilization of immature myeloid cells, which exacerbates inflammation and accelerates colon carcinogenesis. Gastroenterology (2013) 144:155-66. doi:10.1053/j.gastro.2012.09.057
    • (2013) Gastroenterology , vol.144 , pp. 155-166
    • Asfaha, S.1    Dubeykovskiy, A.N.2    Tomita, H.3    Yang, X.4    Stokes, S.5    Shibata, W.6
  • 65
    • 53049095891 scopus 로고    scopus 로고
    • Polymorphisms in VEGF and IL-8 predict tumor recurrence in stage III colon cancer
    • Lurje G, Zhang W, Schultheis AM, Yang D, Groshen S, Hendifar AE, et al. Polymorphisms in VEGF and IL-8 predict tumor recurrence in stage III colon cancer. Ann Oncol (2008) 19:1734-41. doi:10.1093/annonc/mdn368
    • (2008) Ann Oncol , vol.19 , pp. 1734-1741
    • Lurje, G.1    Zhang, W.2    Schultheis, A.M.3    Yang, D.4    Groshen, S.5    Hendifar, A.E.6
  • 66
    • 79959994448 scopus 로고    scopus 로고
    • SNAIL regulates interleukin-8 expression, stem cell-like activity, and tumorigenicity of human colorectal carcinoma cells
    • Hwang WL, Yang MH, Tsai ML, Lan HY, Su SH, Chang SC, et al. SNAIL regulates interleukin-8 expression, stem cell-like activity, and tumorigenicity of human colorectal carcinoma cells. Gastroenterology (2011) 141:e271-5. doi:10.1053/j.gastro.2011.04.008
    • (2011) Gastroenterology , vol.141 , pp. e271-e275
    • Hwang, W.L.1    Yang, M.H.2    Tsai, M.L.3    Lan, H.Y.4    Su, S.H.5    Chang, S.C.6
  • 67
    • 61349100687 scopus 로고    scopus 로고
    • Myeloid-derived suppressor cells as regulators of the immune system
    • Gabrilovich DI, Nagaraj S. Myeloid-derived suppressor cells as regulators of the immune system. Nat Rev Immunol (2009) 9:162-74. doi:10.1038/nri2506
    • (2009) Nat Rev Immunol , vol.9 , pp. 162-174
    • Gabrilovich, D.I.1    Nagaraj, S.2
  • 68
    • 0034792393 scopus 로고    scopus 로고
    • Expression of interleukin 8 and its receptors in human colon carcinoma cells with different metastatic potentials
    • Li A, Varney ML, Singh RK. Expression of interleukin 8 and its receptors in human colon carcinoma cells with different metastatic potentials. Clin Cancer Res (2001) 7:3298-304
    • (2001) Clin Cancer Res , vol.7 , pp. 3298-3304
    • Li, A.1    Varney, M.L.2    Singh, R.K.3
  • 69
    • 79952471898 scopus 로고    scopus 로고
    • Interleukin-8 is associated with proliferation, migration, angiogenesis and chemosensitivity in vitro and in vivo in colon cancer cell line models
    • Ning Y, Manegold PC, Hong YK, Zhang W, Pohl A, Lurje G, et al. Interleukin-8 is associated with proliferation, migration, angiogenesis and chemosensitivity in vitro and in vivo in colon cancer cell line models. Int J Cancer (2011) 128:2038-49. doi:10.1002/ijc.25562
    • (2011) Int J Cancer , vol.128 , pp. 2038-2049
    • Ning, Y.1    Manegold, P.C.2    Hong, Y.K.3    Zhang, W.4    Pohl, A.5    Lurje, G.6
  • 70
    • 58149232586 scopus 로고    scopus 로고
    • The interleukin-8 pathway in cancer
    • Waugh DJ, Wilson C. The interleukin-8 pathway in cancer. Clin Cancer Res (2008) 14:6735-41. doi:10.1158/1078-0432.CCR-07-4843
    • (2008) Clin Cancer Res , vol.14 , pp. 6735-6741
    • Waugh, D.J.1    Wilson, C.2
  • 71
    • 84879332695 scopus 로고    scopus 로고
    • The role of interleukin-9 in lymphoma
    • Lv X, Wang X. The role of interleukin-9 in lymphoma. Leuk Lymphoma (2013) 54:1367-72. doi:10.3109/10428194.2012.745072
    • (2013) Leuk Lymphoma , vol.54 , pp. 1367-1372
    • Lv, X.1    Wang, X.2
  • 72
    • 84864648969 scopus 로고    scopus 로고
    • Robust tumor immunity to melanoma mediated by interleukin-9-producing T cells
    • Purwar R, Schlapbach C, Xiao S, Kang HS, Elyaman W, Jiang X, et al. Robust tumor immunity to melanoma mediated by interleukin-9-producing T cells. Nat Med (2012) 18:1248-53. doi:10.1038/nm.2856
    • (2012) Nat Med , vol.18 , pp. 1248-1253
    • Purwar, R.1    Schlapbach, C.2    Xiao, S.3    Kang, H.S.4    Elyaman, W.5    Jiang, X.6
  • 73
    • 84934435293 scopus 로고    scopus 로고
    • IL-9 inhibits HTB-72 melanoma cell growth through upregulation of p21 and TRAIL
    • Fang Y, Chen X, Bai Q, Qin C, Mohamud AO, Zhu Z, et al. IL-9 inhibits HTB-72 melanoma cell growth through upregulation of p21 and TRAIL. J Surg Oncol (2015) 111:969-74. doi:10.1002/jso.23930
    • (2015) J Surg Oncol , vol.111 , pp. 969-974
    • Fang, Y.1    Chen, X.2    Bai, Q.3    Qin, C.4    Mohamud, A.O.5    Zhu, Z.6
  • 74
    • 84937680554 scopus 로고    scopus 로고
    • Association between low expression levels of interleukin-9 and colon cancer progression
    • Huang Y, Cao Y, Zhang S, Gao F. Association between low expression levels of interleukin-9 and colon cancer progression. Exp Ther Med (2015) 10:942-6. doi:10.3892/etm.2015.2588
    • (2015) Exp Ther Med , vol.10 , pp. 942-946
    • Huang, Y.1    Cao, Y.2    Zhang, S.3    Gao, F.4
  • 75
    • 84917709115 scopus 로고    scopus 로고
    • Inhibition of adaptive immunity by IL9 can be disrupted to achieve rapid T-cell sensitization and rejection of progressive tumor challenges
    • Hoelzinger DB, Dominguez AL, Cohen PA, Gendler SJ. Inhibition of adaptive immunity by IL9 can be disrupted to achieve rapid T-cell sensitization and rejection of progressive tumor challenges. Cancer Res (2014) 74:6845-55. doi:10.1158/0008-5472.CAN-14-0836
    • (2014) Cancer Res , vol.74 , pp. 6845-6855
    • Hoelzinger, D.B.1    Dominguez, A.L.2    Cohen, P.A.3    Gendler, S.J.4
  • 76
    • 32044442107 scopus 로고    scopus 로고
    • Induction of enhanced immunity to intestinal nematodes using IL-9-producing dendritic cells
    • Leech MD, Grencis RK. Induction of enhanced immunity to intestinal nematodes using IL-9-producing dendritic cells. J Immunol (2006) 176:2505-11. doi:10.4049/jimmunol.176.4.2505
    • (2006) J Immunol , vol.176 , pp. 2505-2511
    • Leech, M.D.1    Grencis, R.K.2
  • 77
    • 56349154943 scopus 로고    scopus 로고
    • Transforming growth factor-beta 'reprograms' the differentiation of T helper 2 cells and promotes an interleukin 9-producing subset
    • Veldhoen M, Uyttenhove C, van Snick J, Helmby H, Westendorf A, Buer J, et al. Transforming growth factor-beta 'reprograms' the differentiation of T helper 2 cells and promotes an interleukin 9-producing subset. Nat Immunol (2008) 9:1341-6. doi:10.1038/ni.1659
    • (2008) Nat Immunol , vol.9 , pp. 1341-1346
    • Veldhoen, M.1    Uyttenhove, C.2    van Snick, J.3    Helmby, H.4    Westendorf, A.5    Buer, J.6
  • 78
    • 84874056674 scopus 로고    scopus 로고
    • IL-9-producing invariant NKT cells protect against DSS-induced colitis in an IL-4-dependent manner
    • Kim HS, Chung DH. IL-9-producing invariant NKT cells protect against DSS-induced colitis in an IL-4-dependent manner. Mucosal Immunol (2013) 6:347-57. doi:10.1038/mi.2012.77
    • (2013) Mucosal Immunol , vol.6 , pp. 347-357
    • Kim, H.S.1    Chung, D.H.2
  • 79
    • 84887108621 scopus 로고    scopus 로고
    • Proteome profiling of cancer-associated fibroblasts identifies novel proinflammatory signatures and prognostic markers for colorectal cancer
    • Torres S, Bartolome RA, Mendes M, Barderas R, Fernandez-Acenero MJ, Pelaez-Garcia A, et al. Proteome profiling of cancer-associated fibroblasts identifies novel proinflammatory signatures and prognostic markers for colorectal cancer. Clin Cancer Res (2013) 19:6006-19. doi:10.1158/1078-0432.CCR-13-1130
    • (2013) Clin Cancer Res , vol.19 , pp. 6006-6019
    • Torres, S.1    Bartolome, R.A.2    Mendes, M.3    Barderas, R.4    Fernandez-Acenero, M.J.5    Pelaez-Garcia, A.6
  • 80
    • 84928584525 scopus 로고    scopus 로고
    • IL-9 and its receptor are predominantly involved in the pathogenesis of UC
    • Nalleweg N, Chiriac MT, Podstawa E, Lehmann C, Rau TT, Atreya R, et al. IL-9 and its receptor are predominantly involved in the pathogenesis of UC. Gut (2015) 64:743-55. doi:10.1136/gutjnl-2013-305947
    • (2015) Gut , vol.64 , pp. 743-755
    • Nalleweg, N.1    Chiriac, M.T.2    Podstawa, E.3    Lehmann, C.4    Rau, T.T.5    Atreya, R.6
  • 81
    • 78751591699 scopus 로고    scopus 로고
    • Expression of phosphorylated Stat5 predicts expression of cyclin D1 and correlates with poor prognosis of colonic adenocarcinoma
    • Mao Y, Li Z, Lou C, Zhang Y. Expression of phosphorylated Stat5 predicts expression of cyclin D1 and correlates with poor prognosis of colonic adenocarcinoma. Int J Colorectal Dis (2011) 26:29-35. doi:10.1007/s00384-010-1090-7
    • (2011) Int J Colorectal Dis , vol.26 , pp. 29-35
    • Mao, Y.1    Li, Z.2    Lou, C.3    Zhang, Y.4
  • 82
    • 0031872995 scopus 로고    scopus 로고
    • Advanced colorectal cancer is associated with impaired interleukin 12 and enhanced interleukin 10 production
    • O'Hara RJ, Greenman J, MacDonald AW, Gaskell KM, Topping KP, Duthie GS, et al. Advanced colorectal cancer is associated with impaired interleukin 12 and enhanced interleukin 10 production. Clin Cancer Res (1998) 4:1943-8
    • (1998) Clin Cancer Res , vol.4 , pp. 1943-1948
    • O'Hara, R.J.1    Greenman, J.2    MacDonald, A.W.3    Gaskell, K.M.4    Topping, K.P.5    Duthie, G.S.6
  • 83
    • 77951971709 scopus 로고    scopus 로고
    • Advanced colorectal cancer is associated with enhanced IL-23 and IL-10 serum levels
    • Stanilov N, Miteva L, Deliysky T, Jovchev J, Stanilova S. Advanced colorectal cancer is associated with enhanced IL-23 and IL-10 serum levels. Lab Med (2010) 41:159-63. doi:10.1309/Lm7t43aqziupiowz
    • (2010) Lab Med , vol.41 , pp. 159-163
    • Stanilov, N.1    Miteva, L.2    Deliysky, T.3    Jovchev, J.4    Stanilova, S.5
  • 84
    • 84919890714 scopus 로고    scopus 로고
    • Significance of-1082A/G polymorphism of IL10 gene for progression of colorectal cancer and IL-10 expression
    • Miteva LD, Stanilov NS, Deliysky TS, Stanilova SA. Significance of-1082A/G polymorphism of IL10 gene for progression of colorectal cancer and IL-10 expression. Tumour Biol (2014) 35:12655-64. doi:10.1007/s13277-014-2589-2
    • (2014) Tumour Biol , vol.35 , pp. 12655-12664
    • Miteva, L.D.1    Stanilov, N.S.2    Deliysky, T.S.3    Stanilova, S.A.4
  • 85
    • 20144375359 scopus 로고    scopus 로고
    • CD4+CD25+ regulatory lymphocytes induce regression of intestinal tumors in ApcMin/+ mice
    • Erdman SE, Sohn JJ, Rao VP, Nambiar PR, Ge Z, Fox JG, et al. CD4+CD25+ regulatory lymphocytes induce regression of intestinal tumors in ApcMin/+ mice. Cancer Res (2005) 65:3998-4004. doi:10.1158/0008-5472.CAN-04-3104
    • (2005) Cancer Res , vol.65 , pp. 3998-4004
    • Erdman, S.E.1    Sohn, J.J.2    Rao, V.P.3    Nambiar, P.R.4    Ge, Z.5    Fox, J.G.6
  • 86
    • 67650462939 scopus 로고    scopus 로고
    • T-regulatory cells shift from a protective anti-inflammatory to a cancer-promoting proinflammatory phenotype in polyposis
    • Gounaris E, Blatner NR, Dennis K, Magnusson F, Gurish MF, Strom TB, et al. T-regulatory cells shift from a protective anti-inflammatory to a cancer-promoting proinflammatory phenotype in polyposis. Cancer Res (2009) 69:5490-7. doi:10.1158/0008-5472.CAN-09-0304
    • (2009) Cancer Res , vol.69 , pp. 5490-5497
    • Gounaris, E.1    Blatner, N.R.2    Dennis, K.3    Magnusson, F.4    Gurish, M.F.5    Strom, T.B.6
  • 87
    • 84907495388 scopus 로고    scopus 로고
    • Oral interleukin-10 alleviates polyposis via neutralization of pathogenic T-regulatory cells
    • Chung AY, Li Q, Blair SJ, De Jesus M, Dennis KL, LeVea C, et al. Oral interleukin-10 alleviates polyposis via neutralization of pathogenic T-regulatory cells. Cancer Res (2014) 74:5377-85. doi:10.1158/0008-5472.CAN-14-0918
    • (2014) Cancer Res , vol.74 , pp. 5377-5385
    • Chung, A.Y.1    Li, Q.2    Blair, S.J.3    De Jesus, M.4    Dennis, K.L.5    LeVea, C.6
  • 88
    • 84885064968 scopus 로고    scopus 로고
    • Adenomatous polyps are driven by microbe-instigated focal inflammation and are controlled by IL-10-producing T cells
    • Dennis KL, Wang Y, Blatner NR, Wang S, Saadalla A, Trudeau E, et al. Adenomatous polyps are driven by microbe-instigated focal inflammation and are controlled by IL-10-producing T cells. Cancer Res (2013) 73:5905-13. doi:10.1158/0008-5472.CAN-13-1511
    • (2013) Cancer Res , vol.73 , pp. 5905-5913
    • Dennis, K.L.1    Wang, Y.2    Blatner, N.R.3    Wang, S.4    Saadalla, A.5    Trudeau, E.6
  • 89
    • 0029813545 scopus 로고    scopus 로고
    • Enterocolitis and colon cancer in interleukin-10-deficient mice are associated with aberrant cytokine production and CD4(+) TH1-like responses
    • Berg DJ, Davidson N, Kuhn R, Muller W, Menon S, Holland G, et al. Enterocolitis and colon cancer in interleukin-10-deficient mice are associated with aberrant cytokine production and CD4(+) TH1-like responses. J Clin Invest (1996) 98:1010-20. doi:10.1172/JCI118861
    • (1996) J Clin Invest , vol.98 , pp. 1010-1020
    • Berg, D.J.1    Davidson, N.2    Kuhn, R.3    Muller, W.4    Menon, S.5    Holland, G.6
  • 90
    • 0030704726 scopus 로고    scopus 로고
    • A CD4+ T-cell subset inhibits antigen-specific T-cell responses and prevents colitis
    • Groux H, O'Garra A, Bigler M, Rouleau M, Antonenko S, de Vries JE, et al. A CD4+ T-cell subset inhibits antigen-specific T-cell responses and prevents colitis. Nature (1997) 389:737-42. doi:10.1038/39614
    • (1997) Nature , vol.389 , pp. 737-742
    • Groux, H.1    O'Garra, A.2    Bigler, M.3    Rouleau, M.4    Antonenko, S.5    de Vries, J.E.6
  • 92
    • 84929192010 scopus 로고    scopus 로고
    • IL-10-producing intestinal macrophages prevent excessive antibacterial innate immunity by limiting IL-23 synthesis
    • Krause P, Morris V, Greenbaum JA, Park Y, Bjoerheden U, Mikulski Z, et al. IL-10-producing intestinal macrophages prevent excessive antibacterial innate immunity by limiting IL-23 synthesis. Nat Commun (2015) 6:7055. doi:10.1038/ncomms8055
    • (2015) Nat Commun , vol.6 , pp. 7055
    • Krause, P.1    Morris, V.2    Greenbaum, J.A.3    Park, Y.4    Bjoerheden, U.5    Mikulski, Z.6
  • 93
    • 0033966397 scopus 로고    scopus 로고
    • Expression of IL-10 receptors on epithelial cells from the murine small and large intestine
    • Denning TL, Campbell NA, Song F, Garofalo RP, Klimpel GR, Reyes VE, et al. Expression of IL-10 receptors on epithelial cells from the murine small and large intestine. Int Immunol (2000) 12:133-9. doi:10.1093/intimm/12.2.133
    • (2000) Int Immunol , vol.12 , pp. 133-139
    • Denning, T.L.1    Campbell, N.A.2    Song, F.3    Garofalo, R.P.4    Klimpel, G.R.5    Reyes, V.E.6
  • 94
    • 84893351700 scopus 로고    scopus 로고
    • Interleukin 10 receptor signaling: master regulator of intestinal mucosal homeostasis in mice and humans
    • Shouval DS, Ouahed J, Biswas A, Goettel JA, Horwitz BH, Klein C, et al. Interleukin 10 receptor signaling: master regulator of intestinal mucosal homeostasis in mice and humans. Adv Immunol (2014) 122:177-210. doi:10.1016/B978-0-12-800267-4.00005-5
    • (2014) Adv Immunol , vol.122 , pp. 177-210
    • Shouval, D.S.1    Ouahed, J.2    Biswas, A.3    Goettel, J.A.4    Horwitz, B.H.5    Klein, C.6
  • 95
    • 0030573991 scopus 로고    scopus 로고
    • IL-10 induces DNA binding activity of three STAT proteins (Stat1, Stat3, and Stat5) and their distinct combinatorial assembly in the promoters of selected genes
    • Wehinger J, Gouilleux F, Groner B, Finke J, Mertelsmann R, Weber-Nordt RM. IL-10 induces DNA binding activity of three STAT proteins (Stat1, Stat3, and Stat5) and their distinct combinatorial assembly in the promoters of selected genes. FEBS Lett (1996) 394:365-70. doi:10.1016/0014-5793(96)00990-8
    • (1996) FEBS Lett , vol.394 , pp. 365-370
    • Wehinger, J.1    Gouilleux, F.2    Groner, B.3    Finke, J.4    Mertelsmann, R.5    Weber-Nordt, R.M.6
  • 96
    • 37249088620 scopus 로고    scopus 로고
    • Expression of interleukin (IL)-11 and IL-11 receptor in human colorectal adenocarcinoma: IL-11 up-regulation of the invasive and proliferative activity of human colorectal carcinoma cells
    • Yoshizaki A, Nakayama T, Yamazumi K, Yakata Y, Taba M, Sekine I. Expression of interleukin (IL)-11 and IL-11 receptor in human colorectal adenocarcinoma: IL-11 up-regulation of the invasive and proliferative activity of human colorectal carcinoma cells. Int J Oncol (2006) 29:869-76. doi:10.3892/ijo.29.4.869
    • (2006) Int J Oncol , vol.29 , pp. 869-876
    • Yoshizaki, A.1    Nakayama, T.2    Yamazumi, K.3    Yakata, Y.4    Taba, M.5    Sekine, I.6
  • 97
    • 84881534116 scopus 로고    scopus 로고
    • Interleukin-11 is the dominant IL-6 family cytokine during gastrointestinal tumorigenesis and can be targeted therapeutically
    • Putoczki TL, Thiem S, Loving A, Busuttil RA, Wilson NJ, Ziegler PK, et al. Interleukin-11 is the dominant IL-6 family cytokine during gastrointestinal tumorigenesis and can be targeted therapeutically. Cancer Cell (2013) 24:257-71. doi:10.1016/j.ccr.2013.06.017
    • (2013) Cancer Cell , vol.24 , pp. 257-271
    • Putoczki, T.L.1    Thiem, S.2    Loving, A.3    Busuttil, R.A.4    Wilson, N.J.5    Ziegler, P.K.6
  • 99
    • 36549030784 scopus 로고    scopus 로고
    • The inhibitory cytokine IL-35 contributes to regulatory T-cell function
    • Collison LW, Workman CJ, Kuo TT, Boyd K, Wang Y, Vignali KM, et al. The inhibitory cytokine IL-35 contributes to regulatory T-cell function. Nature (2007) 450:566-9. doi:10.1038/nature06306
    • (2007) Nature , vol.450 , pp. 566-569
    • Collison, L.W.1    Workman, C.J.2    Kuo, T.T.3    Boyd, K.4    Wang, Y.5    Vignali, K.M.6
  • 100
    • 36248970671 scopus 로고    scopus 로고
    • IL-35 is a novel cytokine with therapeutic effects against collagen-induced arthritis through the expansion of regulatory T cells and suppression of Th17 cells
    • Niedbala W, Wei XQ, Cai B, Hueber AJ, Leung BP, McInnes IB, et al. IL-35 is a novel cytokine with therapeutic effects against collagen-induced arthritis through the expansion of regulatory T cells and suppression of Th17 cells. Eur J Immunol (2007) 37:3021-9. doi:10.1002/eji.200737810
    • (2007) Eur J Immunol , vol.37 , pp. 3021-3029
    • Niedbala, W.1    Wei, X.Q.2    Cai, B.3    Hueber, A.J.4    Leung, B.P.5    McInnes, I.B.6
  • 101
    • 0033638507 scopus 로고    scopus 로고
    • Novel p19 protein engages IL-12p40 to form a cytokine, IL-23, with biological activities similar as well as distinct from IL-12
    • Oppmann B, Lesley R, Blom B, Timans JC, Xu Y, Hunte B, et al. Novel p19 protein engages IL-12p40 to form a cytokine, IL-23, with biological activities similar as well as distinct from IL-12. Immunity (2000) 13:715-25. doi:10.1016/S1074-7613(00)00070-4
    • (2000) Immunity , vol.13 , pp. 715-725
    • Oppmann, B.1    Lesley, R.2    Blom, B.3    Timans, J.C.4    Xu, Y.5    Hunte, B.6
  • 102
    • 84922480473 scopus 로고    scopus 로고
    • The prognostic value of preoperative serum levels of IL-12p40 and IL-23 for survival of patients with colorectal cancer
    • Stanilov N, Miteva L, Jovchev J, Cirovski G, Stanilova S. The prognostic value of preoperative serum levels of IL-12p40 and IL-23 for survival of patients with colorectal cancer. APMIS (2014) 122:1223-9. doi:10.1111/apm.12288
    • (2014) APMIS , vol.122 , pp. 1223-1229
    • Stanilov, N.1    Miteva, L.2    Jovchev, J.3    Cirovski, G.4    Stanilova, S.5
  • 103
    • 84876872556 scopus 로고    scopus 로고
    • Dendritic cell inhibition correlates with survival of colorectal cancer patients on bevacizumab treatment
    • Michielsen AJ, Ryan EJ, O'Sullivan JN. Dendritic cell inhibition correlates with survival of colorectal cancer patients on bevacizumab treatment. Oncoimmunology (2012) 1:1445-7. doi:10.4161/onci.21318
    • (2012) Oncoimmunology , vol.1 , pp. 1445-1447
    • Michielsen, A.J.1    Ryan, E.J.2    O'Sullivan, J.N.3
  • 104
    • 0027239503 scopus 로고
    • Antitumor and antimetastatic activity of interleukin 12 against murine tumors
    • Brunda MJ, Luistro L, Warrier RR, Wright RB, Hubbard BR, Murphy M, et al. Antitumor and antimetastatic activity of interleukin 12 against murine tumors. J Exp Med (1993) 178:1223-30. doi:10.1084/jem.178.4.1223
    • (1993) J Exp Med , vol.178 , pp. 1223-1230
    • Brunda, M.J.1    Luistro, L.2    Warrier, R.R.3    Wright, R.B.4    Hubbard, B.R.5    Murphy, M.6
  • 105
    • 0027963161 scopus 로고
    • Recombinant IL-12 administration induces tumor regression in association with IFN-gamma production
    • Nastala CL, Edington HD, McKinney TG, Tahara H, Nalesnik MA, Brunda MJ, et al. Recombinant IL-12 administration induces tumor regression in association with IFN-gamma production. J Immunol (1994) 153:1697-706
    • (1994) J Immunol , vol.153 , pp. 1697-1706
    • Nastala, C.L.1    Edington, H.D.2    McKinney, T.G.3    Tahara, H.4    Nalesnik, M.A.5    Brunda, M.J.6
  • 106
    • 0034284460 scopus 로고    scopus 로고
    • The anti-tumor activity of IL-12: mechanisms of innate immunity that are model and dose dependent
    • Smyth MJ, Taniguchi M, Street SE. The anti-tumor activity of IL-12: mechanisms of innate immunity that are model and dose dependent. J Immunol (2000) 165:2665-70. doi:10.4049/jimmunol.165.5.2665
    • (2000) J Immunol , vol.165 , pp. 2665-2670
    • Smyth, M.J.1    Taniguchi, M.2    Street, S.E.3
  • 107
    • 77958153282 scopus 로고    scopus 로고
    • IL-12 initiates tumor rejection via lymphoid tissue-inducer cells bearing the natural cytotoxicity receptor NKp46
    • Eisenring M, vom Berg J, Kristiansen G, Saller E, Becher B. IL-12 initiates tumor rejection via lymphoid tissue-inducer cells bearing the natural cytotoxicity receptor NKp46. Nat Immunol (2010) 11:1030-8. doi:10.1038/ni.1947
    • (2010) Nat Immunol , vol.11 , pp. 1030-1038
    • Eisenring, M.1    vom Berg, J.2    Kristiansen, G.3    Saller, E.4    Becher, B.5
  • 108
    • 13544270758 scopus 로고    scopus 로고
    • Production of interleukin (IL)-10 and IL-12 by murine colonic dendritic cells in response to microbial stimuli
    • Rigby RJ, Knight SC, Kamm MA, Stagg AJ. Production of interleukin (IL)-10 and IL-12 by murine colonic dendritic cells in response to microbial stimuli. Clin Exp Immunol (2005) 139:245-56. doi:10.1111/j.1365-2249.2004.02674.x
    • (2005) Clin Exp Immunol , vol.139 , pp. 245-256
    • Rigby, R.J.1    Knight, S.C.2    Kamm, M.A.3    Stagg, A.J.4
  • 109
    • 34447107856 scopus 로고    scopus 로고
    • Inducible IL-12-producing B cells regulate Th2-mediated intestinal inflammation
    • Sugimoto K, Ogawa A, Shimomura Y, Nagahama K, Mizoguchi A, Bhan AK. Inducible IL-12-producing B cells regulate Th2-mediated intestinal inflammation. Gastroenterology (2007) 133:124-36. doi:10.1053/j.gastro.2007.03.112
    • (2007) Gastroenterology , vol.133 , pp. 124-136
    • Sugimoto, K.1    Ogawa, A.2    Shimomura, Y.3    Nagahama, K.4    Mizoguchi, A.5    Bhan, A.K.6
  • 110
    • 84896759216 scopus 로고    scopus 로고
    • The dichotomous pattern of IL-12r and IL-23R expression elucidates the role of IL-12 and IL-23 in inflammation
    • Chognard G, Bellemare L, Pelletier AN, Dominguez-Punaro MC, Beauchamp C, Guyon MJ, et al. The dichotomous pattern of IL-12r and IL-23R expression elucidates the role of IL-12 and IL-23 in inflammation. PLoS One (2014) 9:e89092. doi:10.1371/journal.pone.0089092
    • (2014) PLoS One , vol.9
    • Chognard, G.1    Bellemare, L.2    Pelletier, A.N.3    Dominguez-Punaro, M.C.4    Beauchamp, C.5    Guyon, M.J.6
  • 111
    • 77957942243 scopus 로고    scopus 로고
    • Anticancer properties of the IL-12 family-focus on colorectal cancer
    • Engel MA, Neurath MF. Anticancer properties of the IL-12 family-focus on colorectal cancer. Curr Med Chem (2010) 17:3303-8. doi:10.2174/092986710793176366
    • (2010) Curr Med Chem , vol.17 , pp. 3303-3308
    • Engel, M.A.1    Neurath, M.F.2
  • 112
    • 0026691714 scopus 로고
    • Regulation of human cytolytic lymphocyte responses by interleukin-12
    • Gately MK, Wolitzky AG, Quinn PM, Chizzonite R. Regulation of human cytolytic lymphocyte responses by interleukin-12. Cell Immunol (1992) 143:127-42. doi:10.1016/0008-8749(92)90011-D
    • (1992) Cell Immunol , vol.143 , pp. 127-142
    • Gately, M.K.1    Wolitzky, A.G.2    Quinn, P.M.3    Chizzonite, R.4
  • 113
    • 0028043326 scopus 로고
    • Interleukin-12: a cytokine produced by antigen-presenting cells with immunoregulatory functions in the generation of T-helper cells type 1 and cytotoxic lymphocytes
    • Trinchieri G. Interleukin-12: a cytokine produced by antigen-presenting cells with immunoregulatory functions in the generation of T-helper cells type 1 and cytotoxic lymphocytes. Blood (1994) 84:4008-27
    • (1994) Blood , vol.84 , pp. 4008-4027
    • Trinchieri, G.1
  • 114
    • 0029040855 scopus 로고
    • Regulation of interleukin-12 expression in human monocytes: selective priming by interferon-gamma of lipopolysaccharide-inducible p35 and p40 genes
    • Hayes MP, Wang J, Norcross MA. Regulation of interleukin-12 expression in human monocytes: selective priming by interferon-gamma of lipopolysaccharide-inducible p35 and p40 genes. Blood (1995) 86:646-50
    • (1995) Blood , vol.86 , pp. 646-650
    • Hayes, M.P.1    Wang, J.2    Norcross, M.A.3
  • 115
    • 0028970060 scopus 로고
    • Interleukin-12: a proinflammatory cytokine with immunoregulatory functions that bridge innate resistance and antigen-specific adaptive immunity
    • Trinchieri G. Interleukin-12: a proinflammatory cytokine with immunoregulatory functions that bridge innate resistance and antigen-specific adaptive immunity. Annu Rev Immunol (1995) 13:251-76. doi:10.1146/annurev.iy.13.040195.001343
    • (1995) Annu Rev Immunol , vol.13 , pp. 251-276
    • Trinchieri, G.1
  • 116
    • 0035294299 scopus 로고    scopus 로고
    • Immunization of HLA-A2+ melanoma patients with MAGE-3 or MelanA peptide-pulsed autologous peripheral blood mononuclear cells plus recombinant human interleukin 12
    • Gajewski TF, Fallarino F, Ashikari A, Sherman M. Immunization of HLA-A2+ melanoma patients with MAGE-3 or MelanA peptide-pulsed autologous peripheral blood mononuclear cells plus recombinant human interleukin 12. Clin Cancer Res (2001) 7:895s-901s
    • (2001) Clin Cancer Res , vol.7 , pp. 895s-901s
    • Gajewski, T.F.1    Fallarino, F.2    Ashikari, A.3    Sherman, M.4
  • 117
    • 2342570309 scopus 로고    scopus 로고
    • Phase I trial of intratumoral injection of an adenovirus encoding interleukin-12 for advanced digestive tumors
    • Sangro B, Mazzolini G, Ruiz J, Herraiz M, Quiroga J, Herrero I, et al. Phase I trial of intratumoral injection of an adenovirus encoding interleukin-12 for advanced digestive tumors. J Clin Oncol (2004) 22:1389-97. doi:10.1200/JCO.2004.04.059
    • (2004) J Clin Oncol , vol.22 , pp. 1389-1397
    • Sangro, B.1    Mazzolini, G.2    Ruiz, J.3    Herraiz, M.4    Quiroga, J.5    Herrero, I.6
  • 118
    • 70949093473 scopus 로고    scopus 로고
    • A phase I trial of paclitaxel and trastuzumab in combination with interleukin-12 in patients with HER2/neu-expressing malignancies
    • Bekaii-Saab TS, Roda JM, Guenterberg KD, Ramaswamy B, Young DC, Ferketich AK, et al. A phase I trial of paclitaxel and trastuzumab in combination with interleukin-12 in patients with HER2/neu-expressing malignancies. Mol Cancer Ther (2009) 8:2983-91. doi:10.1158/1535-7163.MCT-09-0820
    • (2009) Mol Cancer Ther , vol.8 , pp. 2983-2991
    • Bekaii-Saab, T.S.1    Roda, J.M.2    Guenterberg, K.D.3    Ramaswamy, B.4    Young, D.C.5    Ferketich, A.K.6
  • 119
    • 84899950432 scopus 로고    scopus 로고
    • Interleukin 12: still a promising candidate for tumor immunotherapy?
    • Lasek W, Zagozdzon R, Jakobisiak M. Interleukin 12: still a promising candidate for tumor immunotherapy? Cancer Immunol Immunother (2014) 63:419-35. doi:10.1007/s00262-014-1523-1
    • (2014) Cancer Immunol Immunother , vol.63 , pp. 419-435
    • Lasek, W.1    Zagozdzon, R.2    Jakobisiak, M.3
  • 121
    • 11244255868 scopus 로고    scopus 로고
    • Role of trans-cellular IL-15 presentation in the activation of NK cell-mediated killing, which leads to enhanced tumor immunosurveillance
    • Kobayashi H, Dubois S, Sato N, Sabzevari H, Sakai Y, Waldmann TA, et al. Role of trans-cellular IL-15 presentation in the activation of NK cell-mediated killing, which leads to enhanced tumor immunosurveillance. Blood (2005) 105:721-7. doi:10.1182/blood-2003-12-4187
    • (2005) Blood , vol.105 , pp. 721-727
    • Kobayashi, H.1    Dubois, S.2    Sato, N.3    Sabzevari, H.4    Sakai, Y.5    Waldmann, T.A.6
  • 122
    • 78650328102 scopus 로고    scopus 로고
    • Simultaneous blockade of multiple immune system inhibitory checkpoints enhances antitumor activity mediated by interleukin-15 in a murine metastatic colon carcinoma model
    • Yu P, Steel JC, Zhang M, Morris JC, Waldmann TA. Simultaneous blockade of multiple immune system inhibitory checkpoints enhances antitumor activity mediated by interleukin-15 in a murine metastatic colon carcinoma model. Clin Cancer Res (2010) 16:6019-28. doi:10.1158/1078-0432.CCR-10-1966
    • (2010) Clin Cancer Res , vol.16 , pp. 6019-6028
    • Yu, P.1    Steel, J.C.2    Zhang, M.3    Morris, J.C.4    Waldmann, T.A.5
  • 123
    • 66149114495 scopus 로고    scopus 로고
    • Interleukin-15 combined with an anti-CD40 antibody provides enhanced therapeutic efficacy for murine models of colon cancer
    • Zhang M, Yao Z, Dubois S, Ju W, Muller JR, Waldmann TA. Interleukin-15 combined with an anti-CD40 antibody provides enhanced therapeutic efficacy for murine models of colon cancer. Proc Natl Acad Sci U S A (2009) 106:7513-8. doi:10.1073/pnas.0902637106
    • (2009) Proc Natl Acad Sci U S A , vol.106 , pp. 7513-7518
    • Zhang, M.1    Yao, Z.2    Dubois, S.3    Ju, W.4    Muller, J.R.5    Waldmann, T.A.6
  • 125
    • 84899005149 scopus 로고    scopus 로고
    • Molecular pathways: interleukin-15 signaling in health and in cancer
    • Mishra A, Sullivan L, Caligiuri MA. Molecular pathways: interleukin-15 signaling in health and in cancer. Clin Cancer Res (2014) 20:2044-50. doi:10.1158/1078-0432.CCR-12-3603
    • (2014) Clin Cancer Res , vol.20 , pp. 2044-2050
    • Mishra, A.1    Sullivan, L.2    Caligiuri, M.A.3
  • 126
    • 84948712534 scopus 로고    scopus 로고
    • IL-15 functions as a danger signal to regulate tissue-resident T cells and tissue destruction
    • Jabri B, Abadie V. IL-15 functions as a danger signal to regulate tissue-resident T cells and tissue destruction. Nat Rev Immunol (2015) 15:771-83. doi:10.1038/nri3919
    • (2015) Nat Rev Immunol , vol.15 , pp. 771-783
    • Jabri, B.1    Abadie, V.2
  • 127
    • 5644277476 scopus 로고    scopus 로고
    • Interleukin-17 family members and inflammation
    • Kolls JK, Linden A. Interleukin-17 family members and inflammation. Immunity (2004) 21:467-76. doi:10.1016/j.immuni.2004.08.018
    • (2004) Immunity , vol.21 , pp. 467-476
    • Kolls, J.K.1    Linden, A.2
  • 128
    • 84867526156 scopus 로고    scopus 로고
    • IL-17A in the tumor microenvironment of the human colorectal adenoma-carcinoma sequence
    • Cui G, Yuan A, Goll R, Florholmen J. IL-17A in the tumor microenvironment of the human colorectal adenoma-carcinoma sequence. Scand J Gastroenterol (2012) 47:1304-12. doi:10.3109/00365521.2012.725089
    • (2012) Scand J Gastroenterol , vol.47 , pp. 1304-1312
    • Cui, G.1    Yuan, A.2    Goll, R.3    Florholmen, J.4
  • 129
    • 84924624351 scopus 로고    scopus 로고
    • Interleukin-17FT7488 allele is associated with a decreased risk of colorectal cancer and tumor progression
    • Nemati K, Golmoghaddam H, Hosseini SV, Ghaderi A, Doroudchi M. Interleukin-17FT7488 allele is associated with a decreased risk of colorectal cancer and tumor progression. Gene (2015) 561:88-94. doi:10.1016/j.gene.2015.02.014
    • (2015) Gene , vol.561 , pp. 88-94
    • Nemati, K.1    Golmoghaddam, H.2    Hosseini, S.V.3    Ghaderi, A.4    Doroudchi, M.5
  • 130
    • 84901800888 scopus 로고    scopus 로고
    • Interleukin-17A modulates circulating tumor cells in tumor draining vein of colorectal cancers and affects metastases
    • Tseng JY, Yang CY, Liang SC, Liu RS, Yang SH, Lin JK, et al. Interleukin-17A modulates circulating tumor cells in tumor draining vein of colorectal cancers and affects metastases. Clin Cancer Res (2014) 20:2885-97. doi:10.1158/1078-0432.CCR-13-2162
    • (2014) Clin Cancer Res , vol.20 , pp. 2885-2897
    • Tseng, J.Y.1    Yang, C.Y.2    Liang, S.C.3    Liu, R.S.4    Yang, S.H.5    Lin, J.K.6
  • 131
    • 84885724091 scopus 로고    scopus 로고
    • Spatiotemporal dynamics of intratumoral immune cells reveal the immune landscape in human cancer
    • Bindea G, Mlecnik B, Tosolini M, Kirilovsky A, Waldner M, Obenauf AC, et al. Spatiotemporal dynamics of intratumoral immune cells reveal the immune landscape in human cancer. Immunity (2013) 39:782-95. doi:10.1016/j.immuni.2013.10.003
    • (2013) Immunity , vol.39 , pp. 782-795
    • Bindea, G.1    Mlecnik, B.2    Tosolini, M.3    Kirilovsky, A.4    Waldner, M.5    Obenauf, A.C.6
  • 133
    • 84859602743 scopus 로고    scopus 로고
    • Role of IL-17A in the development of colitis-associated cancer
    • Hyun YS, Han DS, Lee AR, Eun CS, Youn J, Kim HY. Role of IL-17A in the development of colitis-associated cancer. Carcinogenesis (2012) 33:931-6. doi:10.1093/carcin/bgs106
    • (2012) Carcinogenesis , vol.33 , pp. 931-936
    • Hyun, Y.S.1    Han, D.S.2    Lee, A.R.3    Eun, C.S.4    Youn, J.5    Kim, H.Y.6
  • 134
    • 33748588423 scopus 로고    scopus 로고
    • The orphan nuclear receptor RORgammat directs the differentiation program of proinflammatory IL-17+ T helper cells
    • Ivanov II, McKenzie BS, Zhou L, Tadokoro CE, Lepelley A, Lafaille JJ, et al. The orphan nuclear receptor RORgammat directs the differentiation program of proinflammatory IL-17+ T helper cells. Cell (2006) 126:1121-33. doi:10.1016/j.cell.2006.07.035
    • (2006) Cell , vol.126 , pp. 1121-1133
    • Ivanov, I.I.1    McKenzie, B.S.2    Zhou, L.3    Tadokoro, C.E.4    Lepelley, A.5    Lafaille, J.J.6
  • 135
    • 84939893259 scopus 로고    scopus 로고
    • Elevated proinflammatory cytokine IL-17A in the adjacent tissues along the adenoma-carcinoma sequence
    • Cui G, Yang H, Zhao J, Yuan A, Florholmen J. Elevated proinflammatory cytokine IL-17A in the adjacent tissues along the adenoma-carcinoma sequence. Pathol Oncol Res (2015) 21:139-46. doi:10.1007/s12253-014-9799-1
    • (2015) Pathol Oncol Res , vol.21 , pp. 139-146
    • Cui, G.1    Yang, H.2    Zhao, J.3    Yuan, A.4    Florholmen, J.5
  • 136
    • 69949120571 scopus 로고    scopus 로고
    • A human colonic commensal promotes colon tumorigenesis via activation of T helper type 17 T cell responses
    • Wu S, Rhee KJ, Albesiano E, Rabizadeh S, Wu X, Yen HR, et al. A human colonic commensal promotes colon tumorigenesis via activation of T helper type 17 T cell responses. Nat Med (2009) 15:1016-22. doi:10.1038/nm.2015
    • (2009) Nat Med , vol.15 , pp. 1016-1022
    • Wu, S.1    Rhee, K.J.2    Albesiano, E.3    Rabizadeh, S.4    Wu, X.5    Yen, H.R.6
  • 137
    • 84866733757 scopus 로고    scopus 로고
    • CD8(+) T cells that produce interleukin-17 regulate myeloid-derived suppressor cells and are associated with survival time of patients with gastric cancer
    • Zhuang Y, Peng LS, Zhao YL, Shi Y, Mao XH, Chen W, et al. CD8(+) T cells that produce interleukin-17 regulate myeloid-derived suppressor cells and are associated with survival time of patients with gastric cancer. Gastroenterology (2012) 143:951e-62e. doi:10.1053/j.gastro.2012.06.010
    • (2012) Gastroenterology , vol.143 , pp. 951e-962e
    • Zhuang, Y.1    Peng, L.S.2    Zhao, Y.L.3    Shi, Y.4    Mao, X.H.5    Chen, W.6
  • 138
    • 84879571464 scopus 로고    scopus 로고
    • Innate lymphoid cells sustain colon cancer through production of interleukin-22 in a mouse model
    • Kirchberger S, Royston DJ, Boulard O, Thornton E, Franchini F, Szabady RL, et al. Innate lymphoid cells sustain colon cancer through production of interleukin-22 in a mouse model. J Exp Med (2013) 210:917-31. doi:10.1084/jem.20122308
    • (2013) J Exp Med , vol.210 , pp. 917-931
    • Kirchberger, S.1    Royston, D.J.2    Boulard, O.3    Thornton, E.4    Franchini, F.5    Szabady, R.L.6
  • 139
    • 84900482064 scopus 로고    scopus 로고
    • gammadeltaT17 cells promote the accumulation and expansion of myeloid-derived suppressor cells in human colorectal cancer
    • Wu P, Wu D, Ni C, Ye J, Chen W, Hu G, et al. gammadeltaT17 cells promote the accumulation and expansion of myeloid-derived suppressor cells in human colorectal cancer. Immunity (2014) 40:785-800. doi:10.1016/j.immuni.2014.03.013
    • (2014) Immunity , vol.40 , pp. 785-800
    • Wu, P.1    Wu, D.2    Ni, C.3    Ye, J.4    Chen, W.5    Hu, G.6
  • 140
    • 84918535539 scopus 로고    scopus 로고
    • Interleukin-17 receptor a signaling in transformed enterocytes promotes early colorectal tumorigenesis
    • Wang K, Kim MK, Di Caro G, Wong J, Shalapour S, Wan J, et al. Interleukin-17 receptor a signaling in transformed enterocytes promotes early colorectal tumorigenesis. Immunity (2014) 41:1052-63. doi:10.1016/j.immuni.2014.11.009
    • (2014) Immunity , vol.41 , pp. 1052-1063
    • Wang, K.1    Kim, M.K.2    Di Caro, G.3    Wong, J.4    Shalapour, S.5    Wan, J.6
  • 141
    • 84939856972 scopus 로고    scopus 로고
    • Distinctive expression pattern of interleukin-17 cytokine family members in colorectal cancer
    • Al-Samadi A, Moossavi S, Salem A, Sotoudeh M, Tuovinen SM, Konttinen YT, et al. Distinctive expression pattern of interleukin-17 cytokine family members in colorectal cancer. Tumour Biol (2015) 1-7. doi:10.1007/s13277-015-3941-x
    • (2015) Tumour Biol , pp. 1-7
    • Al-Samadi, A.1    Moossavi, S.2    Salem, A.3    Sotoudeh, M.4    Tuovinen, S.M.5    Konttinen, Y.T.6
  • 142
    • 84939209351 scopus 로고    scopus 로고
    • Involvement of IL17A, IL17F and IL23R polymorphisms in colorectal cancer therapy
    • Omrane I, Medimegh I, Baroudi O, Ayari H, Bedhiafi W, Stambouli N, et al. Involvement of IL17A, IL17F and IL23R polymorphisms in colorectal cancer therapy. PLoS One (2015) 10:e0128911. doi:10.1371/journal.pone.0128911
    • (2015) PLoS One , vol.10
    • Omrane, I.1    Medimegh, I.2    Baroudi, O.3    Ayari, H.4    Bedhiafi, W.5    Stambouli, N.6
  • 143
    • 84859578124 scopus 로고    scopus 로고
    • A protective role by interleukin-17F in colon tumorigenesis
    • Tong Z, Yang XO, Yan H, Liu W, Niu X, Shi Y, et al. A protective role by interleukin-17F in colon tumorigenesis. PLoS One (2012) 7:e34959. doi:10.1371/journal.pone.0034959
    • (2012) PLoS One , vol.7
    • Tong, Z.1    Yang, X.O.2    Yan, H.3    Liu, W.4    Niu, X.5    Shi, Y.6
  • 144
    • 0035887627 scopus 로고    scopus 로고
    • Cutting edge: IL-17F, a novel cytokine selectively expressed in activated T cells and monocytes, regulates angiogenesis and endothelial cell cytokine production
    • Starnes T, Robertson MJ, Sledge G, Kelich S, Nakshatri H, Broxmeyer HE, et al. Cutting edge: IL-17F, a novel cytokine selectively expressed in activated T cells and monocytes, regulates angiogenesis and endothelial cell cytokine production. J Immunol (2001) 167:4137-40. doi:10.4049/jimmunol.167.8.4137
    • (2001) J Immunol , vol.167 , pp. 4137-4140
    • Starnes, T.1    Robertson, M.J.2    Sledge, G.3    Kelich, S.4    Nakshatri, H.5    Broxmeyer, H.E.6
  • 145
    • 68849084891 scopus 로고    scopus 로고
    • Structure and signalling in the IL-17 receptor family
    • Gaffen SL. Structure and signalling in the IL-17 receptor family. Nat Rev Immunol (2009) 9:556-67. doi:10.1038/nri2586
    • (2009) Nat Rev Immunol , vol.9 , pp. 556-567
    • Gaffen, S.L.1
  • 146
    • 85028276122 scopus 로고    scopus 로고
    • Th17-type cytokines, IL-6 and TNF-alpha synergistically activate STAT3 and NF-kB to promote colorectal cancer cell growth
    • De Simone V, Franze E, Ronchetti G, Colantoni A, Fantini MC, Di Fusco D, et al. Th17-type cytokines, IL-6 and TNF-alpha synergistically activate STAT3 and NF-kB to promote colorectal cancer cell growth. Oncogene (2015) 34:3493-503. doi:10.1038/onc.2014.286
    • (2015) Oncogene , vol.34 , pp. 3493-3503
    • De Simone, V.1    Franze, E.2    Ronchetti, G.3    Colantoni, A.4    Fantini, M.C.5    Di Fusco, D.6
  • 147
    • 37549051684 scopus 로고    scopus 로고
    • Heterozygosity for interleukin-18-607 A/C polymorphism is associated with risk for colorectal cancer
    • Nikiteas N, Yannopoulos A, Chatzitheofylaktou A, Tsigris C. Heterozygosity for interleukin-18-607 A/C polymorphism is associated with risk for colorectal cancer. Anticancer Res (2007) 27:3849-53
    • (2007) Anticancer Res , vol.27 , pp. 3849-3853
    • Nikiteas, N.1    Yannopoulos, A.2    Chatzitheofylaktou, A.3    Tsigris, C.4
  • 148
    • 0033064554 scopus 로고    scopus 로고
    • Modulation of interleukin-18 expression in human colon carcinoma: consequences for tumor immune surveillance
    • Pages F, Berger A, Henglein B, Piqueras B, Danel C, Zinzindohoue F, et al. Modulation of interleukin-18 expression in human colon carcinoma: consequences for tumor immune surveillance. Int J Cancer (1999) 84:326-30. doi:10.1002/(SICI)1097-0215(19990621)84:3<326::AID-IJC22>3.3.CO;2-B
    • (1999) Int J Cancer , vol.84 , pp. 326-330
    • Pages, F.1    Berger, A.2    Henglein, B.3    Piqueras, B.4    Danel, C.5    Zinzindohoue, F.6
  • 149
    • 42749096082 scopus 로고    scopus 로고
    • Genetic analysis of innate immunity in Crohn's disease and ulcerative colitis identifies two susceptibility loci harboring CARD9 and IL18RAP
    • Zhernakova A, Festen EM, Franke L, Trynka G, van Diemen CC, Monsuur AJ, et al. Genetic analysis of innate immunity in Crohn's disease and ulcerative colitis identifies two susceptibility loci harboring CARD9 and IL18RAP. Am J Hum Genet (2008) 82:1202-10. doi:10.1016/j.ajhg.2008.03.016
    • (2008) Am J Hum Genet , vol.82 , pp. 1202-1210
    • Zhernakova, A.1    Festen, E.M.2    Franke, L.3    Trynka, G.4    van Diemen, C.C.5    Monsuur, A.J.6
  • 150
    • 77953464026 scopus 로고    scopus 로고
    • Nlrp3: an immune sensor of cellular stress and infection
    • Lamkanfi M, Kanneganti TD. Nlrp3: an immune sensor of cellular stress and infection. Int J Biochem Cell Biol (2010) 42:792-5. doi:10.1016/j.biocel.2010.01.008
    • (2010) Int J Biochem Cell Biol , vol.42 , pp. 792-795
    • Lamkanfi, M.1    Kanneganti, T.D.2
  • 151
    • 78650624793 scopus 로고    scopus 로고
    • Innate immune mechanisms of colitis and colitis-associated colorectal cancer
    • Saleh M, Trinchieri G. Innate immune mechanisms of colitis and colitis-associated colorectal cancer. Nat Rev Immunol (2011) 11:9-20. doi:10.1038/nri2891
    • (2011) Nat Rev Immunol , vol.11 , pp. 9-20
    • Saleh, M.1    Trinchieri, G.2
  • 152
    • 77955350419 scopus 로고    scopus 로고
    • MyD88-mediated signaling prevents development of adenocarcinomas of the colon: role of interleukin 18
    • Salcedo R, Worschech A, Cardone M, Jones Y, Gyulai Z, Dai RM, et al. MyD88-mediated signaling prevents development of adenocarcinomas of the colon: role of interleukin 18. J Exp Med (2010) 207:1625-36. doi:10.1084/jem.20100199
    • (2010) J Exp Med , vol.207 , pp. 1625-1636
    • Salcedo, R.1    Worschech, A.2    Cardone, M.3    Jones, Y.4    Gyulai, Z.5    Dai, R.M.6
  • 153
    • 78049488908 scopus 로고    scopus 로고
    • IL-18 production downstream of the Nlrp3 inflammasome confers protection against colorectal tumor formation
    • Zaki MH, Vogel P, Body-Malapel M, Lamkanfi M, Kanneganti TD. IL-18 production downstream of the Nlrp3 inflammasome confers protection against colorectal tumor formation. J Immunol (2010) 185:4912-20. doi:10.4049/jimmunol.1002046
    • (2010) J Immunol , vol.185 , pp. 4912-4920
    • Zaki, M.H.1    Vogel, P.2    Body-Malapel, M.3    Lamkanfi, M.4    Kanneganti, T.D.5
  • 154
    • 84939570120 scopus 로고    scopus 로고
    • Epithelial-derived IL-18 regulates Th17 cell differentiation and Foxp3(+) Treg cell function in the intestine
    • Harrison OJ, Srinivasan N, Pott J, Schiering C, Krausgruber T, Ilott NE, et al. Epithelial-derived IL-18 regulates Th17 cell differentiation and Foxp3(+) Treg cell function in the intestine. Mucosal Immunol (2015) 8:1226-36. doi:10.1038/mi.2015.13
    • (2015) Mucosal Immunol , vol.8 , pp. 1226-1236
    • Harrison, O.J.1    Srinivasan, N.2    Pott, J.3    Schiering, C.4    Krausgruber, T.5    Ilott, N.E.6
  • 155
    • 77949965210 scopus 로고    scopus 로고
    • Control of intestinal homeostasis, colitis, and colitis-associated colorectal cancer by the inflammatory caspases
    • Dupaul-Chicoine J, Yeretssian G, Doiron K, Bergstrom KS, McIntire CR, LeBlanc PM, et al. Control of intestinal homeostasis, colitis, and colitis-associated colorectal cancer by the inflammatory caspases. Immunity (2010) 32:367-78. doi:10.1016/j.immuni.2010.02.012
    • (2010) Immunity , vol.32 , pp. 367-378
    • Dupaul-Chicoine, J.1    Yeretssian, G.2    Doiron, K.3    Bergstrom, K.S.4    McIntire, C.R.5    LeBlanc, P.M.6
  • 156
    • 77950002937 scopus 로고    scopus 로고
    • The NLRP3 inflammasome protects against loss of epithelial integrity and mortality during experimental colitis
    • Zaki MH, Boyd KL, Vogel P, Kastan MB, Lamkanfi M, Kanneganti TD. The NLRP3 inflammasome protects against loss of epithelial integrity and mortality during experimental colitis. Immunity (2010) 32:379-91. doi:10.1016/j.immuni.2010.03.003
    • (2010) Immunity , vol.32 , pp. 379-391
    • Zaki, M.H.1    Boyd, K.L.2    Vogel, P.3    Kastan, M.B.4    Lamkanfi, M.5    Kanneganti, T.D.6
  • 157
    • 84868615556 scopus 로고    scopus 로고
    • IL-22BP is regulated by the inflammasome and modulates tumorigenesis in the intestine
    • Huber S, Gagliani N, Zenewicz LA, Huber FJ, Bosurgi L, Hu B, et al. IL-22BP is regulated by the inflammasome and modulates tumorigenesis in the intestine. Nature (2012) 491:259-63. doi:10.1038/nature11535
    • (2012) Nature , vol.491 , pp. 259-263
    • Huber, S.1    Gagliani, N.2    Zenewicz, L.A.3    Huber, F.J.4    Bosurgi, L.5    Hu, B.6
  • 158
    • 0034453608 scopus 로고    scopus 로고
    • Proinflammatory and antitumor properties of interleukin-18 in the gastrointestinal tract
    • Pages F, Berger A, Lebel-Binay S, Zinzindohoue F, Danel C, Piqueras B, et al. Proinflammatory and antitumor properties of interleukin-18 in the gastrointestinal tract. Immunol Lett (2000) 75:9-14. doi:10.1016/S0165-2478(00)00285-6
    • (2000) Immunol Lett , vol.75 , pp. 9-14
    • Pages, F.1    Berger, A.2    Lebel-Binay, S.3    Zinzindohoue, F.4    Danel, C.5    Piqueras, B.6
  • 159
    • 80055105733 scopus 로고    scopus 로고
    • Involvement of interleukin-21 in the regulation of colitis-associated colon cancer
    • Stolfi C, Rizzo A, Franze E, Rotondi A, Fantini MC, Sarra M, et al. Involvement of interleukin-21 in the regulation of colitis-associated colon cancer. J Exp Med (2011) 208:2279-90. doi:10.1084/jem.20111106
    • (2011) J Exp Med , vol.208 , pp. 2279-2290
    • Stolfi, C.1    Rizzo, A.2    Franze, E.3    Rotondi, A.4    Fantini, M.C.5    Sarra, M.6
  • 160
    • 84857786741 scopus 로고    scopus 로고
    • A phase 1 trial of recombinant human IL-21 in combination with cetuximab in patients with metastatic colorectal cancer
    • Steele N, Anthony A, Saunders M, Esmarck B, Ehrnrooth E, Kristjansen PE, et al. A phase 1 trial of recombinant human IL-21 in combination with cetuximab in patients with metastatic colorectal cancer. Br J Cancer (2012) 106:793-8. doi:10.1038/bjc.2011.599
    • (2012) Br J Cancer , vol.106 , pp. 793-798
    • Steele, N.1    Anthony, A.2    Saunders, M.3    Esmarck, B.4    Ehrnrooth, E.5    Kristjansen, P.E.6
  • 161
    • 80655125038 scopus 로고    scopus 로고
    • Interleukin 21 controls tumour growth and tumour immunosurveillance in colitis-associated tumorigenesis in mice
    • Jauch D, Martin M, Schiechl G, Kesselring R, Schlitt HJ, Geissler EK, et al. Interleukin 21 controls tumour growth and tumour immunosurveillance in colitis-associated tumorigenesis in mice. Gut (2011) 60:1678-86. doi:10.1136/gutjnl-2011-300612
    • (2011) Gut , vol.60 , pp. 1678-1686
    • Jauch, D.1    Martin, M.2    Schiechl, G.3    Kesselring, R.4    Schlitt, H.J.5    Geissler, E.K.6
  • 162
    • 84878066887 scopus 로고    scopus 로고
    • Role of IL-21 and IL-21 receptor on B cells in HIV infection
    • Pallikkuth S, Parmigiani A, Pahwa S. Role of IL-21 and IL-21 receptor on B cells in HIV infection. Crit Rev Immunol (2012) 32:173-95. doi:10.1615/CritRevImmunol.v32.i2.50
    • (2012) Crit Rev Immunol , vol.32 , pp. 173-195
    • Pallikkuth, S.1    Parmigiani, A.2    Pahwa, S.3
  • 163
    • 84899979288 scopus 로고    scopus 로고
    • Interleukin-21: a double-edged sword with therapeutic potential
    • Spolski R, Leonard WJ. Interleukin-21: a double-edged sword with therapeutic potential. Nat Rev Drug Discov (2014) 13:379-95. doi:10.1038/nrd4296
    • (2014) Nat Rev Drug Discov , vol.13 , pp. 379-395
    • Spolski, R.1    Leonard, W.J.2
  • 164
    • 2542595794 scopus 로고    scopus 로고
    • IL-21 enhances and sustains CD8+ T cell responses to achieve durable tumor immunity: comparative evaluation of IL-2, IL-15, and IL-21
    • Moroz A, Eppolito C, Li Q, Tao J, Clegg CH, Shrikant PA. IL-21 enhances and sustains CD8+ T cell responses to achieve durable tumor immunity: comparative evaluation of IL-2, IL-15, and IL-21. J Immunol (2004) 173:900-9. doi:10.4049/jimmunol.173.2.900
    • (2004) J Immunol , vol.173 , pp. 900-909
    • Moroz, A.1    Eppolito, C.2    Li, Q.3    Tao, J.4    Clegg, C.H.5    Shrikant, P.A.6
  • 166
    • 84927654352 scopus 로고    scopus 로고
    • Th22 cell accumulation is associated with colorectal cancer development
    • Huang YH, Cao YF, Jiang ZY, Zhang S, Gao F. Th22 cell accumulation is associated with colorectal cancer development. World J Gastroenterol (2015) 21:4216-24. doi:10.3748/wjg.v21.i14.4216
    • (2015) World J Gastroenterol , vol.21 , pp. 4216-4224
    • Huang, Y.H.1    Cao, Y.F.2    Jiang, Z.Y.3    Zhang, S.4    Gao, F.5
  • 167
    • 84908470068 scopus 로고    scopus 로고
    • Interleukin 22 protects colorectal cancer cells from chemotherapy by activating the STAT3 pathway and inducing autocrine expression of interleukin 8
    • Wu T, Wang Z, Liu Y, Mei Z, Wang G, Liang Z, et al. Interleukin 22 protects colorectal cancer cells from chemotherapy by activating the STAT3 pathway and inducing autocrine expression of interleukin 8. Clin Immunol (2014) 154:116-26. doi:10.1016/j.clim.2014.07.005
    • (2014) Clin Immunol , vol.154 , pp. 116-126
    • Wu, T.1    Wang, Z.2    Liu, Y.3    Mei, Z.4    Wang, G.5    Liang, Z.6
  • 169
    • 38849141814 scopus 로고    scopus 로고
    • IL-22 ameliorates intestinal inflammation in a mouse model of ulcerative colitis
    • Sugimoto K, Ogawa A, Mizoguchi E, Shimomura Y, Andoh A, Bhan AK, et al. IL-22 ameliorates intestinal inflammation in a mouse model of ulcerative colitis. J Clin Invest (2008) 118:534-44. doi:10.1172/JCI33194
    • (2008) J Clin Invest , vol.118 , pp. 534-544
    • Sugimoto, K.1    Ogawa, A.2    Mizoguchi, E.3    Shimomura, Y.4    Andoh, A.5    Bhan, A.K.6
  • 171
    • 67650474246 scopus 로고    scopus 로고
    • STAT3 links IL-22 signaling in intestinal epithelial cells to mucosal wound healing
    • Pickert G, Neufert C, Leppkes M, Zheng Y, Wittkopf N, Warntjen M, et al. STAT3 links IL-22 signaling in intestinal epithelial cells to mucosal wound healing. J Exp Med (2009) 206:1465-72. doi:10.1084/jem.20082683
    • (2009) J Exp Med , vol.206 , pp. 1465-1472
    • Pickert, G.1    Neufert, C.2    Leppkes, M.3    Zheng, Y.4    Wittkopf, N.5    Warntjen, M.6
  • 172
    • 84900459331 scopus 로고    scopus 로고
    • IL-22(+)CD4(+) T cells promote colorectal cancer stemness via STAT3 transcription factor activation and induction of the methyltransferase DOT1L
    • Kryczek I, Lin Y, Nagarsheth N, Peng D, Zhao L, Zhao E, et al. IL-22(+)CD4(+) T cells promote colorectal cancer stemness via STAT3 transcription factor activation and induction of the methyltransferase DOT1L. Immunity (2014) 40:772-84. doi:10.1016/j.immuni.2014.03.010
    • (2014) Immunity , vol.40 , pp. 772-784
    • Kryczek, I.1    Lin, Y.2    Nagarsheth, N.3    Peng, D.4    Zhao, L.5    Zhao, E.6
  • 173
    • 84957557636 scopus 로고    scopus 로고
    • IL10R2 overexpression promotes IL22/STAT3 signaling in colorectal carcinogenesis
    • Khare V, Paul G, Movadat O, Frick A, Jambrich M, Krnjic A, et al. IL10R2 overexpression promotes IL22/STAT3 signaling in colorectal carcinogenesis. Cancer Immunol Res (2015) 3:1227-35. doi:10.1158/2326-6066.CIR-15-0031
    • (2015) Cancer Immunol Res , vol.3 , pp. 1227-1235
    • Khare, V.1    Paul, G.2    Movadat, O.3    Frick, A.4    Jambrich, M.5    Krnjic, A.6
  • 174
    • 84900453541 scopus 로고    scopus 로고
    • IL-22 gets to the stem of colorectal cancer
    • Koltsova EK, Grivennikov SI. IL-22 gets to the stem of colorectal cancer. Immunity (2014) 40:639-41. doi:10.1016/j.immuni.2014.04.014
    • (2014) Immunity , vol.40 , pp. 639-641
    • Koltsova, E.K.1    Grivennikov, S.I.2
  • 175
    • 77953522676 scopus 로고    scopus 로고
    • Elevated serum level of IL-23 correlates with expression of VEGF in human colorectal carcinoma
    • Ljujic B, Radosavljevic G, Jovanovic I, Pavlovic S, Zdravkovic N, Milovanovic M, et al. Elevated serum level of IL-23 correlates with expression of VEGF in human colorectal carcinoma. Arch Med Res (2010) 41:182-9. doi:10.1016/j.arcmed.2010.02.009
    • (2010) Arch Med Res , vol.41 , pp. 182-189
    • Ljujic, B.1    Radosavljevic, G.2    Jovanovic, I.3    Pavlovic, S.4    Zdravkovic, N.5    Milovanovic, M.6
  • 177
    • 84904679757 scopus 로고    scopus 로고
    • IL-23 selectively promotes the metastasis of colorectal carcinoma cells with impaired Socs3 expression via the STAT5 pathway
    • Zhang L, Li J, Li L, Zhang J, Wang X, Yang C, et al. IL-23 selectively promotes the metastasis of colorectal carcinoma cells with impaired Socs3 expression via the STAT5 pathway. Carcinogenesis (2014) 35:1330-40. doi:10.1093/carcin/bgu017
    • (2014) Carcinogenesis , vol.35 , pp. 1330-1340
    • Zhang, L.1    Li, J.2    Li, L.3    Zhang, J.4    Wang, X.5    Yang, C.6
  • 178
    • 45749107055 scopus 로고    scopus 로고
    • Unique CD14 intestinal macrophages contribute to the pathogenesis of Crohn disease via IL-23/IFN-gamma axis
    • Kamada N, Hisamatsu T, Okamoto S, Chinen H, Kobayashi T, Sato T, et al. Unique CD14 intestinal macrophages contribute to the pathogenesis of Crohn disease via IL-23/IFN-gamma axis. J Clin Invest (2008) 118:2269-80. doi:10.1172/JCI34610
    • (2008) J Clin Invest , vol.118 , pp. 2269-2280
    • Kamada, N.1    Hisamatsu, T.2    Okamoto, S.3    Chinen, H.4    Kobayashi, T.5    Sato, T.6
  • 179
    • 84857444876 scopus 로고    scopus 로고
    • Interleukin 23 production by intestinal CD103(+)CD11b(+) dendritic cells in response to bacterial flagellin enhances mucosal innate immune defense
    • Kinnebrew MA, Buffie CG, Diehl GE, Zenewicz LA, Leiner I, Hohl TM, et al. Interleukin 23 production by intestinal CD103(+)CD11b(+) dendritic cells in response to bacterial flagellin enhances mucosal innate immune defense. Immunity (2012) 36:276-87. doi:10.1016/j.immuni.2011.12.011
    • (2012) Immunity , vol.36 , pp. 276-287
    • Kinnebrew, M.A.1    Buffie, C.G.2    Diehl, G.E.3    Zenewicz, L.A.4    Leiner, I.5    Hohl, T.M.6
  • 180
    • 84937622124 scopus 로고    scopus 로고
    • Tissue-infiltrating neutrophils represent the main source of IL-23 in the colon of patients with IBD
    • Kvedaraite E, Lourda M, Idestrom M, Chen P, Olsson-Akefeldt S, Forkel M, et al. Tissue-infiltrating neutrophils represent the main source of IL-23 in the colon of patients with IBD. Gut (2015) 1-10. doi:10.1136/gutjnl-2014-309014
    • (2015) Gut , pp. 1-10
    • Kvedaraite, E.1    Lourda, M.2    Idestrom, M.3    Chen, P.4    Olsson-Akefeldt, S.5    Forkel, M.6
  • 181
    • 77955890952 scopus 로고    scopus 로고
    • Interleukin-23 drives intestinal inflammation through direct activity on T cells
    • Ahern PP, Schiering C, Buonocore S, McGeachy MJ, Cua DJ, Maloy KJ, et al. Interleukin-23 drives intestinal inflammation through direct activity on T cells. Immunity (2010) 33:279-88. doi:10.1016/j.immuni.2010.08.010
    • (2010) Immunity , vol.33 , pp. 279-288
    • Ahern, P.P.1    Schiering, C.2    Buonocore, S.3    McGeachy, M.J.4    Cua, D.J.5    Maloy, K.J.6
  • 182
    • 79958277385 scopus 로고    scopus 로고
    • IL-23-responsive innate lymphoid cells are increased in inflammatory bowel disease
    • Geremia A, Arancibia-Carcamo CV, Fleming MP, Rust N, Singh B, Mortensen NJ, et al. IL-23-responsive innate lymphoid cells are increased in inflammatory bowel disease. J Exp Med (2011) 208:1127-33. doi:10.1084/jem.20101712
    • (2011) J Exp Med , vol.208 , pp. 1127-1133
    • Geremia, A.1    Arancibia-Carcamo, C.V.2    Fleming, M.P.3    Rust, N.4    Singh, B.5    Mortensen, N.J.6
  • 184
    • 33750505009 scopus 로고    scopus 로고
    • Interleukin-23 drives innate and T cell-mediated intestinal inflammation
    • Hue S, Ahern P, Buonocore S, Kullberg MC, Cua DJ, McKenzie BS, et al. Interleukin-23 drives innate and T cell-mediated intestinal inflammation. J Exp Med (2006) 203:2473-83. doi:10.1084/jem.20061099
    • (2006) J Exp Med , vol.203 , pp. 2473-2483
    • Hue, S.1    Ahern, P.2    Buonocore, S.3    Kullberg, M.C.4    Cua, D.J.5    McKenzie, B.S.6
  • 185
    • 33750530394 scopus 로고    scopus 로고
    • IL-23 plays a key role in Helicobacter hepaticus-induced T cell-dependent colitis
    • Kullberg MC, Jankovic D, Feng CG, Hue S, Gorelick PL, McKenzie BS, et al. IL-23 plays a key role in Helicobacter hepaticus-induced T cell-dependent colitis. J Exp Med (2006) 203:2485-94. doi:10.1084/jem.20061082
    • (2006) J Exp Med , vol.203 , pp. 2485-2494
    • Kullberg, M.C.1    Jankovic, D.2    Feng, C.G.3    Hue, S.4    Gorelick, P.L.5    McKenzie, B.S.6
  • 186
    • 33646397611 scopus 로고    scopus 로고
    • IL-23 is essential for T cell-mediated colitis and promotes inflammation via IL-17 and IL-6
    • Yen D, Cheung J, Scheerens H, Poulet F, McClanahan T, McKenzie B, et al. IL-23 is essential for T cell-mediated colitis and promotes inflammation via IL-17 and IL-6. J Clin Invest (2006) 116:1310-6. doi:10.1172/JCI21404
    • (2006) J Clin Invest , vol.116 , pp. 1310-1316
    • Yen, D.1    Cheung, J.2    Scheerens, H.3    Poulet, F.4    McClanahan, T.5    McKenzie, B.6
  • 187
    • 75549087056 scopus 로고    scopus 로고
    • Disease-associated functions of IL-33: the new kid in the IL-1 family
    • Liew FY, Pitman NI, McInnes IB. Disease-associated functions of IL-33: the new kid in the IL-1 family. Nat Rev Immunol (2010) 10:103-10. doi:10.1038/nri2692
    • (2010) Nat Rev Immunol , vol.10 , pp. 103-110
    • Liew, F.Y.1    Pitman, N.I.2    McInnes, I.B.3
  • 188
    • 78649821588 scopus 로고    scopus 로고
    • IL-33 is a crucial amplifier of innate rather than acquired immunity
    • Oboki K, Ohno T, Kajiwara N, Arae K, Morita H, Ishii A, et al. IL-33 is a crucial amplifier of innate rather than acquired immunity. Proc Natl Acad Sci U S A (2010) 107:18581-6. doi:10.1073/pnas.1003059107
    • (2010) Proc Natl Acad Sci U S A , vol.107 , pp. 18581-18586
    • Oboki, K.1    Ohno, T.2    Kajiwara, N.3    Arae, K.4    Morita, H.5    Ishii, A.6
  • 189
    • 84873716709 scopus 로고    scopus 로고
    • Mechanisms of IL-33 processing and secretion: differences and similarities between IL-1 family members
    • Lefrancais E, Cayrol C. Mechanisms of IL-33 processing and secretion: differences and similarities between IL-1 family members. Eur Cytokine Netw (2012) 23:120-7. doi:10.1684/ecn.2012.0320
    • (2012) Eur Cytokine Netw , vol.23 , pp. 120-127
    • Lefrancais, E.1    Cayrol, C.2
  • 191
    • 77952324145 scopus 로고    scopus 로고
    • Epithelial-derived IL-33 and its receptor ST2 are dysregulated in ulcerative colitis and in experimental Th1/Th2 driven enteritis
    • Pastorelli L, Garg RR, Hoang SB, Spina L, Mattioli B, Scarpa M, et al. Epithelial-derived IL-33 and its receptor ST2 are dysregulated in ulcerative colitis and in experimental Th1/Th2 driven enteritis. Proc Natl Acad Sci U S A (2010) 107:8017-22. doi:10.1073/pnas.0912678107
    • (2010) Proc Natl Acad Sci U S A , vol.107 , pp. 8017-8022
    • Pastorelli, L.1    Garg, R.R.2    Hoang, S.B.3    Spina, L.4    Mattioli, B.5    Scarpa, M.6
  • 192
    • 84887459057 scopus 로고    scopus 로고
    • Neutralisation of the interleukin-33/ST2 pathway ameliorates experimental colitis through enhancement of mucosal healing in mice
    • Sedhom MA, Pichery M, Murdoch JR, Foligne B, Ortega N, Normand S, et al. Neutralisation of the interleukin-33/ST2 pathway ameliorates experimental colitis through enhancement of mucosal healing in mice. Gut (2013) 62:1714-23. doi:10.1136/gutjnl-2011-301785
    • (2013) Gut , vol.62 , pp. 1714-1723
    • Sedhom, M.A.1    Pichery, M.2    Murdoch, J.R.3    Foligne, B.4    Ortega, N.5    Normand, S.6
  • 193
    • 84866386408 scopus 로고    scopus 로고
    • IL-33 attenuates development and perpetuation of chronic intestinal inflammation
    • Grobeta P, Doser K, Falk W, Obermeier F, Hofmann C. IL-33 attenuates development and perpetuation of chronic intestinal inflammation. Inflamm Bowel Dis (2012) 18:1900-9. doi:10.1002/ibd.22900
    • (2012) Inflamm Bowel Dis , vol.18 , pp. 1900-1909
    • Grobeta, P.1    Doser, K.2    Falk, W.3    Obermeier, F.4    Hofmann, C.5
  • 194
  • 195
    • 84922433330 scopus 로고    scopus 로고
    • Dynamics of the IL-33/ST2 network in the progression of human colorectal adenoma to sporadic colorectal cancer
    • Cui G, Qi H, Gundersen MD, Yang H, Christiansen I, Sorbye SW, et al. Dynamics of the IL-33/ST2 network in the progression of human colorectal adenoma to sporadic colorectal cancer. Cancer Immunol Immunother (2015) 64:181-90. doi:10.1007/s00262-014-1624-x
    • (2015) Cancer Immunol Immunother , vol.64 , pp. 181-190
    • Cui, G.1    Qi, H.2    Gundersen, M.D.3    Yang, H.4    Christiansen, I.5    Sorbye, S.W.6
  • 197
    • 33846101552 scopus 로고    scopus 로고
    • IL-33, the IL-1-like cytokine ligand for ST2 receptor, is a chromatin-associated nuclear factor in vivo
    • Carriere V, Roussel L, Ortega N, Lacorre DA, Americh L, Aguilar L, et al. IL-33, the IL-1-like cytokine ligand for ST2 receptor, is a chromatin-associated nuclear factor in vivo. Proc Natl Acad Sci U S A (2007) 104:282-7. doi:10.1073/pnas.0606854104
    • (2007) Proc Natl Acad Sci U S A , vol.104 , pp. 282-287
    • Carriere, V.1    Roussel, L.2    Ortega, N.3    Lacorre, D.A.4    Americh, L.5    Aguilar, L.6
  • 198
    • 84936761972 scopus 로고    scopus 로고
    • IL-33 signaling contributes to the pathogenesis of myeloproliferative neoplasms
    • Mager LF, Riether C, Schurch CM, Banz Y, Wasmer MH, Stuber R, et al. IL-33 signaling contributes to the pathogenesis of myeloproliferative neoplasms. J Clin Invest (2015) 125:2579-91. doi:10.1172/JCI77347
    • (2015) J Clin Invest , vol.125 , pp. 2579-2591
    • Mager, L.F.1    Riether, C.2    Schurch, C.M.3    Banz, Y.4    Wasmer, M.H.5    Stuber, R.6
  • 199
    • 84954393953 scopus 로고    scopus 로고
    • An antitumorigenic role for the IL-33 receptor, ST2L, in colon cancer
    • O'Donnell C, Mahmoud A, Keane J, Murphy C, White D, Carey S, et al. An antitumorigenic role for the IL-33 receptor, ST2L, in colon cancer. Br J Cancer (2016) 114:37-43. doi:10.1038/bjc.2015.433
    • (2016) Br J Cancer , vol.114 , pp. 37-43
    • O'Donnell, C.1    Mahmoud, A.2    Keane, J.3    Murphy, C.4    White, D.5    Carey, S.6
  • 200
    • 84918555747 scopus 로고    scopus 로고
    • IL-33/ST2 pathway contributes to metastasis of human colorectal cancer
    • Liu X, Zhu L, Lu X, Bian H, Wu X, Yang W, et al. IL-33/ST2 pathway contributes to metastasis of human colorectal cancer. Biochem Biophys Res Commun (2014) 453:486-92. doi:10.1016/j.bbrc.2014.09.106
    • (2014) Biochem Biophys Res Commun , vol.453 , pp. 486-492
    • Liu, X.1    Zhu, L.2    Lu, X.3    Bian, H.4    Wu, X.5    Yang, W.6
  • 201
    • 78650199530 scopus 로고    scopus 로고
    • Inflammatory bowel disease-associated interleukin-33 is preferentially expressed in ulceration-associated myofibroblasts
    • Sponheim J, Pollheimer J, Olsen T, Balogh J, Hammarstrom C, Loos T, et al. Inflammatory bowel disease-associated interleukin-33 is preferentially expressed in ulceration-associated myofibroblasts. Am J Pathol (2010) 177:2804-15. doi:10.2353/ajpath.2010.100378
    • (2010) Am J Pathol , vol.177 , pp. 2804-2815
    • Sponheim, J.1    Pollheimer, J.2    Olsen, T.3    Balogh, J.4    Hammarstrom, C.5    Loos, T.6
  • 202
    • 84859378165 scopus 로고    scopus 로고
    • Endogenous IL-33 is highly expressed in mouse epithelial barrier tissues, lymphoid organs, brain, embryos, and inflamed tissues: in situ analysis using a novel Il-33-LacZ gene trap reporter strain
    • Pichery M, Mirey E, Mercier P, Lefrancais E, Dujardin A, Ortega N, et al. Endogenous IL-33 is highly expressed in mouse epithelial barrier tissues, lymphoid organs, brain, embryos, and inflamed tissues: in situ analysis using a novel Il-33-LacZ gene trap reporter strain. J Immunol (2012) 188:3488-95. doi:10.4049/jimmunol.1101977
    • (2012) J Immunol , vol.188 , pp. 3488-3495
    • Pichery, M.1    Mirey, E.2    Mercier, P.3    Lefrancais, E.4    Dujardin, A.5    Ortega, N.6
  • 203
    • 70449475108 scopus 로고    scopus 로고
    • Interleukin-33 induces angiogenesis and vascular permeability through ST2/TRAF6-mediated endothelial nitric oxide production
    • Choi YS, Choi HJ, Min JK, Pyun BJ, Maeng YS, Park H, et al. Interleukin-33 induces angiogenesis and vascular permeability through ST2/TRAF6-mediated endothelial nitric oxide production. Blood (2009) 114:3117-26. doi:10.1182/blood-2009-02-203372
    • (2009) Blood , vol.114 , pp. 3117-3126
    • Choi, Y.S.1    Choi, H.J.2    Min, J.K.3    Pyun, B.J.4    Maeng, Y.S.5    Park, H.6
  • 204
    • 84902109000 scopus 로고    scopus 로고
    • Interleukin-33 induces urokinase in human endothelial cells-possible impact on angiogenesis
    • Stojkovic S, Kaun C, Heinz M, Krychtiuk KA, Rauscher S, Lemberger CE, et al. Interleukin-33 induces urokinase in human endothelial cells-possible impact on angiogenesis. J Thromb Haemost (2014) 12:948-57. doi:10.1111/jth.12581
    • (2014) J Thromb Haemost , vol.12 , pp. 948-957
    • Stojkovic, S.1    Kaun, C.2    Heinz, M.3    Krychtiuk, K.A.4    Rauscher, S.5    Lemberger, C.E.6
  • 205
    • 84871960166 scopus 로고    scopus 로고
    • Immune-dependent and independent antitumor activity of GM-CSF aberrantly expressed by mouse and human colorectal tumors
    • Urdinguio RG, Fernandez AF, Moncada-Pazos A, Huidobro C, Rodriguez RM, Ferrero C, et al. Immune-dependent and independent antitumor activity of GM-CSF aberrantly expressed by mouse and human colorectal tumors. Cancer Res (2013) 73:395-405. doi:10.1158/0008-5472.CAN-12-0806
    • (2013) Cancer Res , vol.73 , pp. 395-405
    • Urdinguio, R.G.1    Fernandez, A.F.2    Moncada-Pazos, A.3    Huidobro, C.4    Rodriguez, R.M.5    Ferrero, C.6
  • 206
    • 84902687656 scopus 로고    scopus 로고
    • GM-CSF production by tumor cells is associated with improved survival in colorectal cancer
    • Nebiker CA, Han J, Eppenberger-Castori S, Iezzi G, Hirt C, Amicarella F, et al. GM-CSF production by tumor cells is associated with improved survival in colorectal cancer. Clin Cancer Res (2014) 20:3094-106. doi:10.1158/1078-0432.CCR-13-2774
    • (2014) Clin Cancer Res , vol.20 , pp. 3094-3106
    • Nebiker, C.A.1    Han, J.2    Eppenberger-Castori, S.3    Iezzi, G.4    Hirt, C.5    Amicarella, F.6
  • 207
    • 84893837713 scopus 로고    scopus 로고
    • Tumor-derived GM-CSF promotes inflammatory colon carcinogenesis via stimulating epithelial release of VEGF
    • Wang Y, Han G, Wang K, Liu G, Wang R, Xiao H, et al. Tumor-derived GM-CSF promotes inflammatory colon carcinogenesis via stimulating epithelial release of VEGF. Cancer Res (2014) 74:716-26. doi:10.1158/0008-5472.CAN-13-1459
    • (2014) Cancer Res , vol.74 , pp. 716-726
    • Wang, Y.1    Han, G.2    Wang, K.3    Liu, G.4    Wang, R.5    Xiao, H.6
  • 208
    • 0031808821 scopus 로고    scopus 로고
    • GM-CSF gene expression and protein production in human colorectal cancer cell lines and clinical tumor specimens
    • Trutmann M, Terracciano L, Noppen C, Kloth J, Kaspar M, Peterli R, et al. GM-CSF gene expression and protein production in human colorectal cancer cell lines and clinical tumor specimens. Int J Cancer (1998) 77:378-85. doi:10.1002/(SICI)1097-0215(19980729)77:3<378::AID-IJC12>3.0.CO;2-4
    • (1998) Int J Cancer , vol.77 , pp. 378-385
    • Trutmann, M.1    Terracciano, L.2    Noppen, C.3    Kloth, J.4    Kaspar, M.5    Peterli, R.6
  • 209
    • 84960335147 scopus 로고    scopus 로고
    • ILC3 GM-CSF production and mobilisation orchestrate acute intestinal inflammation
    • Pearson C, Thornton EE, McKenzie B, Schaupp AL, Huskens N, Griseri T, et al. ILC3 GM-CSF production and mobilisation orchestrate acute intestinal inflammation. Elife (2016) 5:e10066. doi:10.7554/eLife.10066
    • (2016) Elife , vol.5
    • Pearson, C.1    Thornton, E.E.2    McKenzie, B.3    Schaupp, A.L.4    Huskens, N.5    Griseri, T.6
  • 210
    • 77958006456 scopus 로고    scopus 로고
    • Cellular vaccine approaches
    • Le DT, Pardoll DM, Jaffee EM. Cellular vaccine approaches. Cancer J (2010) 16:304-10. doi:10.1097/PPO.0b013e3181eb33d7
    • (2010) Cancer J , vol.16 , pp. 304-310
    • Le, D.T.1    Pardoll, D.M.2    Jaffee, E.M.3
  • 211
    • 84937689047 scopus 로고    scopus 로고
    • Granulocyte macrophage colony-stimulating factor-activated eosinophils promote interleukin-23 driven chronic colitis
    • Griseri T, Arnold IC, Pearson C, Krausgruber T, Schiering C, Franchini F, et al. Granulocyte macrophage colony-stimulating factor-activated eosinophils promote interleukin-23 driven chronic colitis. Immunity (2015) 43:187-99. doi:10.1016/j.immuni.2015.07.008
    • (2015) Immunity , vol.43 , pp. 187-199
    • Griseri, T.1    Arnold, I.C.2    Pearson, C.3    Krausgruber, T.4    Schiering, C.5    Franchini, F.6
  • 212
    • 0342424368 scopus 로고    scopus 로고
    • Prognostic influence of tumor-associated eosinophilic infiltrate in colorectal carcinoma
    • Fernandez-Acenero MJ, Galindo-Gallego M, Sanz J, Aljama A. Prognostic influence of tumor-associated eosinophilic infiltrate in colorectal carcinoma. Cancer (2000) 88:1544-8. doi:10.1002/(SICI)1097-0142(20000401)88:7<1544::AID-CNCR7>3.3.CO;2-J
    • (2000) Cancer , vol.88 , pp. 1544-1548
    • Fernandez-Acenero, M.J.1    Galindo-Gallego, M.2    Sanz, J.3    Aljama, A.4
  • 213
    • 70349336496 scopus 로고    scopus 로고
    • The granulocyte-macrophage colony-stimulating factor receptor: linking its structure to cell signaling and its role in disease
    • Hercus TR, Thomas D, Guthridge MA, Ekert PG, King-Scott J, Parker MW, et al. The granulocyte-macrophage colony-stimulating factor receptor: linking its structure to cell signaling and its role in disease. Blood (2009) 114:1289-98. doi:10.1182/blood-2008-12-164004
    • (2009) Blood , vol.114 , pp. 1289-1298
    • Hercus, T.R.1    Thomas, D.2    Guthridge, M.A.3    Ekert, P.G.4    King-Scott, J.5    Parker, M.W.6
  • 214
    • 84908867157 scopus 로고    scopus 로고
    • Expression and DNA methylation of TNF, IFNG and FOXP3 in colorectal cancer and their prognostic significance
    • Ganapathi SK, Beggs AD, Hodgson SV, Kumar D. Expression and DNA methylation of TNF, IFNG and FOXP3 in colorectal cancer and their prognostic significance. Br J Cancer (2014) 111:1581-9. doi:10.1038/bjc.2014.477
    • (2014) Br J Cancer , vol.111 , pp. 1581-1589
    • Ganapathi, S.K.1    Beggs, A.D.2    Hodgson, S.V.3    Kumar, D.4
  • 215
    • 33646849272 scopus 로고    scopus 로고
    • The correlation between colorectal cancer rates of proliferation and apoptosis and systemic cytokine levels; plus their influence upon survival
    • Evans C, Morrison I, Heriot AG, Bartlett JB, Finlayson C, Dalgleish AG, et al. The correlation between colorectal cancer rates of proliferation and apoptosis and systemic cytokine levels; plus their influence upon survival. Br J Cancer (2006) 94:1412-9. doi:10.1038/sj.bjc.6603104
    • (2006) Br J Cancer , vol.94 , pp. 1412-1419
    • Evans, C.1    Morrison, I.2    Heriot, A.G.3    Bartlett, J.B.4    Finlayson, C.5    Dalgleish, A.G.6
  • 216
    • 84926456534 scopus 로고    scopus 로고
    • Deficiency of interferon-gamma or its receptor promotes colorectal cancer development
    • Wang L, Wang Y, Song Z, Chu J, Qu X. Deficiency of interferon-gamma or its receptor promotes colorectal cancer development. J Interferon Cytokine Res (2015) 35:273-80. doi:10.1089/jir.2014.0132
    • (2015) J Interferon Cytokine Res , vol.35 , pp. 273-280
    • Wang, L.1    Wang, Y.2    Song, Z.3    Chu, J.4    Qu, X.5
  • 217
    • 0036839071 scopus 로고    scopus 로고
    • Most murine CD8+ intestinal intraepithelial lymphocytes are partially but not fully activated T cells
    • Wang HC, Zhou Q, Dragoo J, Klein JR. Most murine CD8+ intestinal intraepithelial lymphocytes are partially but not fully activated T cells. J Immunol (2002) 169:4717-22. doi:10.4049/jimmunol.169.9.4717
    • (2002) J Immunol , vol.169 , pp. 4717-4722
    • Wang, H.C.1    Zhou, Q.2    Dragoo, J.3    Klein, J.R.4
  • 218
    • 34848908792 scopus 로고    scopus 로고
    • IFN-gamma-producing dendritic cells are important for priming of gut intraepithelial lymphocyte response against intracellular parasitic infection
    • Moretto MM, Weiss LM, Combe CL, Khan IA. IFN-gamma-producing dendritic cells are important for priming of gut intraepithelial lymphocyte response against intracellular parasitic infection. J Immunol (2007) 179:2485-92. doi:10.4049/jimmunol.179.4.2485
    • (2007) J Immunol , vol.179 , pp. 2485-2492
    • Moretto, M.M.1    Weiss, L.M.2    Combe, C.L.3    Khan, I.A.4
  • 219
    • 70349675873 scopus 로고    scopus 로고
    • Production of interferon-gamma by activated T-cell receptor-alphabeta CD8alphabeta intestinal intraepithelial lymphocytes is required and sufficient for disruption of the intestinal barrier integrity
    • Zufferey C, Erhart D, Saurer L, Mueller C. Production of interferon-gamma by activated T-cell receptor-alphabeta CD8alphabeta intestinal intraepithelial lymphocytes is required and sufficient for disruption of the intestinal barrier integrity. Immunology (2009) 128:351-9. doi:10.1111/j.1365-2567.2009.03110.x
    • (2009) Immunology , vol.128 , pp. 351-359
    • Zufferey, C.1    Erhart, D.2    Saurer, L.3    Mueller, C.4
  • 220
  • 221
    • 33750321707 scopus 로고    scopus 로고
    • Interferons, immunity and cancer immunoediting
    • Dunn GP, Koebel CM, Schreiber RD. Interferons, immunity and cancer immunoediting. Nat Rev Immunol (2006) 6:836-48. doi:10.1038/nri1961
    • (2006) Nat Rev Immunol , vol.6 , pp. 836-848
    • Dunn, G.P.1    Koebel, C.M.2    Schreiber, R.D.3
  • 222
    • 84880271158 scopus 로고    scopus 로고
    • Both STAT1 and STAT3 are favourable prognostic determinants in colorectal carcinoma
    • Gordziel C, Bratsch J, Moriggl R, Knosel T, Friedrich K. Both STAT1 and STAT3 are favourable prognostic determinants in colorectal carcinoma. Br J Cancer (2013) 109:138-46. doi:10.1038/bjc.2013.274
    • (2013) Br J Cancer , vol.109 , pp. 138-146
    • Gordziel, C.1    Bratsch, J.2    Moriggl, R.3    Knosel, T.4    Friedrich, K.5
  • 223
    • 0024553788 scopus 로고
    • Interferon-gamma directly affects barrier function of cultured intestinal epithelial monolayers
    • Madara JL, Stafford J. Interferon-gamma directly affects barrier function of cultured intestinal epithelial monolayers. J Clin Invest (1989) 83:724-7. doi:10.1172/JCI113938
    • (1989) J Clin Invest , vol.83 , pp. 724-727
    • Madara, J.L.1    Stafford, J.2
  • 224
    • 0032977248 scopus 로고    scopus 로고
    • Interferon-gamma decreases barrier function in T84 cells by reducing ZO-1 levels and disrupting apical actin
    • Youakim A, Ahdieh M. Interferon-gamma decreases barrier function in T84 cells by reducing ZO-1 levels and disrupting apical actin. Am J Physiol (1999) 276:G1279-88
    • (1999) Am J Physiol , vol.276 , pp. G1279-G1288
    • Youakim, A.1    Ahdieh, M.2
  • 225
    • 27644477373 scopus 로고    scopus 로고
    • Abrogation of IFN-gamma mediated epithelial barrier disruption by serine protease inhibition
    • Willemsen LE, Hoetjes JP, van Deventer SJ, van Tol EA. Abrogation of IFN-gamma mediated epithelial barrier disruption by serine protease inhibition. Clin Exp Immunol (2005) 142:275-84. doi:10.1111/j.1365-2249.2005.02906.x
    • (2005) Clin Exp Immunol , vol.142 , pp. 275-284
    • Willemsen, L.E.1    Hoetjes, J.P.2    van Deventer, S.J.3    van Tol, E.A.4
  • 226
    • 0042324629 scopus 로고    scopus 로고
    • Stress-induced disruption of colonic epithelial barrier: role of interferon-gamma and myosin light chain kinase in mice
    • Ferrier L, Mazelin L, Cenac N, Desreumaux P, Janin A, Emilie D, et al. Stress-induced disruption of colonic epithelial barrier: role of interferon-gamma and myosin light chain kinase in mice. Gastroenterology (2003) 125:795-804. doi:10.1016/S0016-5085(03)01057-6
    • (2003) Gastroenterology , vol.125 , pp. 795-804
    • Ferrier, L.1    Mazelin, L.2    Cenac, N.3    Desreumaux, P.4    Janin, A.5    Emilie, D.6
  • 227
    • 0033565626 scopus 로고    scopus 로고
    • Transforming growth factor beta1 suppresses nonmetastatic colon cancer at an early stage of tumorigenesis
    • Engle SJ, Hoying JB, Boivin GP, Ormsby I, Gartside PS, Doetschman T. Transforming growth factor beta1 suppresses nonmetastatic colon cancer at an early stage of tumorigenesis. Cancer Res (1999) 59:3379-86
    • (1999) Cancer Res , vol.59 , pp. 3379-3386
    • Engle, S.J.1    Hoying, J.B.2    Boivin, G.P.3    Ormsby, I.4    Gartside, P.S.5    Doetschman, T.6
  • 228
    • 3142664714 scopus 로고    scopus 로고
    • Transforming growth factor beta receptor type II inactivation promotes the establishment and progression of colon cancer
    • Biswas S, Chytil A, Washington K, Romero-Gallo J, Gorska AE, Wirth PS, et al. Transforming growth factor beta receptor type II inactivation promotes the establishment and progression of colon cancer. Cancer Res (2004) 64:4687-92. doi:10.1158/0008-5472.CAN-03-3255
    • (2004) Cancer Res , vol.64 , pp. 4687-4692
    • Biswas, S.1    Chytil, A.2    Washington, K.3    Romero-Gallo, J.4    Gorska, A.E.5    Wirth, P.S.6
  • 231
    • 0029740157 scopus 로고    scopus 로고
    • Transforming growth factor beta 1 expression in human colorectal tumours: an independent prognostic marker in a subgroup of poor prognosis patients
    • Robson H, Anderson E, James RD, Schofield PF. Transforming growth factor beta 1 expression in human colorectal tumours: an independent prognostic marker in a subgroup of poor prognosis patients. Br J Cancer (1996) 74:753-8. doi:10.1038/bjc.1996.432
    • (1996) Br J Cancer , vol.74 , pp. 753-758
    • Robson, H.1    Anderson, E.2    James, R.D.3    Schofield, P.F.4
  • 232
    • 0034896088 scopus 로고    scopus 로고
    • Circulating transforming growth factor beta 1 as a predictor of liver metastasis after resection in colorectal cancer
    • Tsushima H, Ito N, Tamura S, Matsuda Y, Inada M, Yabuuchi I, et al. Circulating transforming growth factor beta 1 as a predictor of liver metastasis after resection in colorectal cancer. Clin Cancer Res (2001) 7:1258-62
    • (2001) Clin Cancer Res , vol.7 , pp. 1258-1262
    • Tsushima, H.1    Ito, N.2    Tamura, S.3    Matsuda, Y.4    Inada, M.5    Yabuuchi, I.6
  • 233
    • 0032489508 scopus 로고    scopus 로고
    • Intestinal tumorigenesis in compound mutant mice of both Dpc4 (Smad4) and Apc genes
    • Takaku K, Oshima M, Miyoshi H, Matsui M, Seldin MF, Taketo MM. Intestinal tumorigenesis in compound mutant mice of both Dpc4 (Smad4) and Apc genes. Cell (1998) 92:645-56. doi:10.1016/S0092-8674(00)81132-0
    • (1998) Cell , vol.92 , pp. 645-656
    • Takaku, K.1    Oshima, M.2    Miyoshi, H.3    Matsui, M.4    Seldin, M.F.5    Taketo, M.M.6
  • 234
    • 84928151672 scopus 로고    scopus 로고
    • miR-1269 promotes metastasis and forms a positive feedback loop with TGF-beta
    • Bu P, Wang L, Chen KY, Rakhilin N, Sun J, Closa A, et al. miR-1269 promotes metastasis and forms a positive feedback loop with TGF-beta. Nat Commun (2015) 6:6879. doi:10.1038/ncomms7879
    • (2015) Nat Commun , vol.6 , pp. 6879
    • Bu, P.1    Wang, L.2    Chen, K.Y.3    Rakhilin, N.4    Sun, J.5    Closa, A.6
  • 235
    • 34547789841 scopus 로고    scopus 로고
    • TGF-beta signaling alterations and susceptibility to colorectal cancer
    • Xu Y, Pasche B. TGF-beta signaling alterations and susceptibility to colorectal cancer. Hum Mol Genet (2007) 16(Spec No 1):R14-20. doi:10.1093/hmg/ddl486
    • (2007) Hum Mol Genet , vol.16 , pp. R14-R20
    • Xu, Y.1    Pasche, B.2
  • 236
    • 78249231410 scopus 로고    scopus 로고
    • Role of transforming growth factor-beta in inflammatory bowel disease and colitis-associated colon cancer
    • Feagins LA. Role of transforming growth factor-beta in inflammatory bowel disease and colitis-associated colon cancer. Inflamm Bowel Dis (2010) 16:1963-8. doi:10.1002/ibd.21281
    • (2010) Inflamm Bowel Dis , vol.16 , pp. 1963-1968
    • Feagins, L.A.1
  • 237
    • 84891748444 scopus 로고    scopus 로고
    • Interaction with colon cancer cells hyperactivates TGF-beta signaling in cancer-associated fibroblasts
    • Hawinkels LJ, Paauwe M, Verspaget HW, Wiercinska E, van der Zon JM, van der Ploeg K, et al. Interaction with colon cancer cells hyperactivates TGF-beta signaling in cancer-associated fibroblasts. Oncogene (2014) 33:97-107. doi:10.1038/onc.2012.536
    • (2014) Oncogene , vol.33 , pp. 97-107
    • Hawinkels, L.J.1    Paauwe, M.2    Verspaget, H.W.3    Wiercinska, E.4    van der Zon, J.M.5    van der Ploeg, K.6
  • 238
    • 0034644472 scopus 로고    scopus 로고
    • TGFbeta signaling in growth control, cancer, and heritable disorders
    • Massague J, Blain SW, Lo RS. TGFbeta signaling in growth control, cancer, and heritable disorders. Cell (2000) 103:295-309. doi:10.1016/S0092-8674(00)00121-5
    • (2000) Cell , vol.103 , pp. 295-309
    • Massague, J.1    Blain, S.W.2    Lo, R.S.3
  • 239
    • 67349162130 scopus 로고    scopus 로고
    • Tumour necrosis factor and cancer
    • Balkwill F. Tumour necrosis factor and cancer. Nat Rev Cancer (2009) 9:361-71. doi:10.1038/nrc2628
    • (2009) Nat Rev Cancer , vol.9 , pp. 361-371
    • Balkwill, F.1
  • 240
  • 241
    • 84912575005 scopus 로고    scopus 로고
    • Colorectal cancer severity and survival in correlation with tumour necrosis factor-alpha
    • Stanilov N, Miteva L, Dobreva Z, Stanilova S. Colorectal cancer severity and survival in correlation with tumour necrosis factor-alpha. Biotechnol Biotechnol Equip (2014) 28:911-7. doi:10.1080/13102818.2014.965047
    • (2014) Biotechnol Biotechnol Equip , vol.28 , pp. 911-917
    • Stanilov, N.1    Miteva, L.2    Dobreva, Z.3    Stanilova, S.4
  • 242
    • 30944442404 scopus 로고    scopus 로고
    • Infliximab and newly diagnosed neoplasia in Crohn's disease: a multicentre matched pair study
    • Biancone L, Orlando A, Kohn A, Colombo E, Sostegni R, Angelucci E, et al. Infliximab and newly diagnosed neoplasia in Crohn's disease: a multicentre matched pair study. Gut (2006) 55:228-33. doi:10.1136/gut.2005.075937
    • (2006) Gut , vol.55 , pp. 228-233
    • Biancone, L.1    Orlando, A.2    Kohn, A.3    Colombo, E.4    Sostegni, R.5    Angelucci, E.6
  • 243
    • 72549112691 scopus 로고    scopus 로고
    • Long-term safety of Infliximab for the treatment of inflammatory bowel disease: does blocking TNFalpha reduce colitis-associated colorectal carcinogenesis?
    • Biancone L, Petruzziello C, Calabrese E, Zorzi F, Naccarato P, Onali S, et al. Long-term safety of Infliximab for the treatment of inflammatory bowel disease: does blocking TNFalpha reduce colitis-associated colorectal carcinogenesis? Gut (2009) 58:1703. doi:10.1136/gut.2008.176461
    • (2009) Gut , vol.58 , pp. 1703
    • Biancone, L.1    Petruzziello, C.2    Calabrese, E.3    Zorzi, F.4    Naccarato, P.5    Onali, S.6
  • 244
    • 63849251824 scopus 로고    scopus 로고
    • Long-term safety of infliximab for the treatment of inflammatory bowel disease: a single-centre cohort study
    • Fidder H, Schnitzler F, Ferrante M, Noman M, Katsanos K, Segaert S, et al. Long-term safety of infliximab for the treatment of inflammatory bowel disease: a single-centre cohort study. Gut (2009) 58:501-8. doi:10.1136/gut.2008.163642
    • (2009) Gut , vol.58 , pp. 501-508
    • Fidder, H.1    Schnitzler, F.2    Ferrante, M.3    Noman, M.4    Katsanos, K.5    Segaert, S.6
  • 245
    • 84896117860 scopus 로고    scopus 로고
    • In vivo imaging using fluorescent antibodies to tumor necrosis factor predicts therapeutic response in Crohn's disease
    • Atreya R, Neumann H, Neufert C, Waldner MJ, Billmeier U, Zopf Y, et al. In vivo imaging using fluorescent antibodies to tumor necrosis factor predicts therapeutic response in Crohn's disease. Nat Med (2014) 20:313-8. doi:10.1038/nm.3462
    • (2014) Nat Med , vol.20 , pp. 313-318
    • Atreya, R.1    Neumann, H.2    Neufert, C.3    Waldner, M.J.4    Billmeier, U.5    Zopf, Y.6
  • 247
    • 38849171267 scopus 로고    scopus 로고
    • Blocking TNF-alpha in mice reduces colorectal carcinogenesis associated with chronic colitis
    • Popivanova BK, Kitamura K, Wu Y, Kondo T, Kagaya T, Kaneko S, et al. Blocking TNF-alpha in mice reduces colorectal carcinogenesis associated with chronic colitis. J Clin Invest (2008) 118:560-70. doi:10.1172/JCI32453
    • (2008) J Clin Invest , vol.118 , pp. 560-570
    • Popivanova, B.K.1    Kitamura, K.2    Wu, Y.3    Kondo, T.4    Kagaya, T.5    Kaneko, S.6
  • 248
    • 84865527211 scopus 로고    scopus 로고
    • Obesity-induced increase in tumor necrosis factor-alpha leads to development of colon cancer in mice
    • Flores MB, Rocha GZ, Damas-Souza DM, Osorio-Costa F, Dias MM, Ropelle ER, et al. Obesity-induced increase in tumor necrosis factor-alpha leads to development of colon cancer in mice. Gastroenterology (2012) 143(741-753):e741-4. doi:10.1053/j.gastro.2012.05.045
    • (2012) Gastroenterology , vol.143 , Issue.741-753 , pp. e741-e744
    • Flores, M.B.1    Rocha, G.Z.2    Damas-Souza, D.M.3    Osorio-Costa, F.4    Dias, M.M.5    Ropelle, E.R.6
  • 249
    • 0026442689 scopus 로고
    • Tumor necrosis factor-alpha-dependent production of reactive nitrogen intermediates mediates IFN-gamma plus IL-2-induced murine macrophage tumoricidal activity
    • Cox GW, Melillo G, Chattopadhyay U, Mullet D, Fertel RH, Varesio L. Tumor necrosis factor-alpha-dependent production of reactive nitrogen intermediates mediates IFN-gamma plus IL-2-induced murine macrophage tumoricidal activity. J Immunol (1992) 149:3290-6
    • (1992) J Immunol , vol.149 , pp. 3290-3296
    • Cox, G.W.1    Melillo, G.2    Chattopadhyay, U.3    Mullet, D.4    Fertel, R.H.5    Varesio, L.6
  • 250
    • 33847029227 scopus 로고    scopus 로고
    • Colon cancer cell-derived tumor necrosis factor-alpha mediates the tumor growth-promoting response in macrophages by up-regulating the colony-stimulating factor-1 pathway
    • Zins K, Abraham D, Sioud M, Aharinejad S. Colon cancer cell-derived tumor necrosis factor-alpha mediates the tumor growth-promoting response in macrophages by up-regulating the colony-stimulating factor-1 pathway. Cancer Res (2007) 67:1038-45. doi:10.1158/0008-5472.CAN-06-2295
    • (2007) Cancer Res , vol.67 , pp. 1038-1045
    • Zins, K.1    Abraham, D.2    Sioud, M.3    Aharinejad, S.4
  • 251
    • 84883410561 scopus 로고    scopus 로고
    • Protective role of tumor necrosis factor (TNF) receptors in chronic intestinal inflammation: TNFR1 ablation boosts systemic inflammatory response
    • Wang Y, Han G, Chen Y, Wang K, Liu G, Wang R, et al. Protective role of tumor necrosis factor (TNF) receptors in chronic intestinal inflammation: TNFR1 ablation boosts systemic inflammatory response. Lab Invest (2013) 93:1024-35. doi:10.1038/labinvest.2013.89
    • (2013) Lab Invest , vol.93 , pp. 1024-1035
    • Wang, Y.1    Han, G.2    Chen, Y.3    Wang, K.4    Liu, G.5    Wang, R.6
  • 252
    • 0036142256 scopus 로고    scopus 로고
    • Role of tumor necrosis factor receptor 2 (TNFR2) in colonic epithelial hyperplasia and chronic intestinal inflammation in mice
    • Mizoguchi E, Mizoguchi A, Takedatsu H, Cario E, de Jong YP, Ooi CJ, et al. Role of tumor necrosis factor receptor 2 (TNFR2) in colonic epithelial hyperplasia and chronic intestinal inflammation in mice. Gastroenterology (2002) 122:134-44. doi:10.1053/gast.2002.30347
    • (2002) Gastroenterology , vol.122 , pp. 134-144
    • Mizoguchi, E.1    Mizoguchi, A.2    Takedatsu, H.3    Cario, E.4    de Jong, Y.P.5    Ooi, C.J.6
  • 253
    • 84055207486 scopus 로고    scopus 로고
    • Cytokine induction of tumor necrosis factor receptor 2 is mediated by STAT3 in colon cancer cells
    • Hamilton KE, Simmons JG, Ding S, Van Landeghem L, Lund PK. Cytokine induction of tumor necrosis factor receptor 2 is mediated by STAT3 in colon cancer cells. Mol Cancer Res (2011) 9:1718-31. doi:10.1158/1541-7786.MCR-10-0210
    • (2011) Mol Cancer Res , vol.9 , pp. 1718-1731
    • Hamilton, K.E.1    Simmons, J.G.2    Ding, S.3    Van Landeghem, L.4    Lund, P.K.5
  • 254
    • 84868629269 scopus 로고    scopus 로고
    • TNF signaling drives myeloid-derived suppressor cell accumulation
    • Zhao X, Rong L, Zhao X, Li X, Liu X, Deng J, et al. TNF signaling drives myeloid-derived suppressor cell accumulation. J Clin Invest (2012) 122:4094-104. doi:10.1172/JCI64115
    • (2012) J Clin Invest , vol.122 , pp. 4094-4104
    • Zhao, X.1    Rong, L.2    Zhao, X.3    Li, X.4    Liu, X.5    Deng, J.6
  • 255
    • 84929875491 scopus 로고    scopus 로고
    • Regulation of tumour necrosis factor signalling: live or let die
    • Brenner D, Blaser H, Mak TW. Regulation of tumour necrosis factor signalling: live or let die. Nat Rev Immunol (2015) 15:362-74. doi:10.1038/nri3834
    • (2015) Nat Rev Immunol , vol.15 , pp. 362-374
    • Brenner, D.1    Blaser, H.2    Mak, T.W.3
  • 256
    • 84864414700 scopus 로고    scopus 로고
    • A novel murine model of inflammatory bowel disease and inflammation-associated colon cancer with ulcerative colitis-like features
    • Hale LP, Greer PK. A novel murine model of inflammatory bowel disease and inflammation-associated colon cancer with ulcerative colitis-like features. PLoS One (2012) 7:e41797. doi:10.1371/journal.pone.0041797
    • (2012) PLoS One , vol.7
    • Hale, L.P.1    Greer, P.K.2
  • 257
    • 73249130655 scopus 로고    scopus 로고
    • Expression of HIF-1alpha and VEGF in colorectal cancer: association with clinical outcomes and prognostic implications
    • Cao D, Hou M, Guan YS, Jiang M, Yang Y, Gou HF. Expression of HIF-1alpha and VEGF in colorectal cancer: association with clinical outcomes and prognostic implications. BMC Cancer (2009) 9:432. doi:10.1186/1471-2407-9-432
    • (2009) BMC Cancer , vol.9 , pp. 432
    • Cao, D.1    Hou, M.2    Guan, Y.S.3    Jiang, M.4    Yang, Y.5    Gou, H.F.6
  • 258
    • 58149150071 scopus 로고    scopus 로고
    • VEGF-1 expression in colorectal cancer is associated with disease localization, stage, and long-term disease-specific survival
    • Bendardaf R, Buhmeida A, Hilska M, Laato M, Syrjanen S, Syrjanen K, et al. VEGF-1 expression in colorectal cancer is associated with disease localization, stage, and long-term disease-specific survival. Anticancer Res (2008) 28:3865-70
    • (2008) Anticancer Res , vol.28 , pp. 3865-3870
    • Bendardaf, R.1    Buhmeida, A.2    Hilska, M.3    Laato, M.4    Syrjanen, S.5    Syrjanen, K.6
  • 259
    • 18244387773 scopus 로고    scopus 로고
    • Danish RANX05 Colorectal Cancer Study Group. Prognostic impact of matched preoperative plasma and serum VEGF in patients with primary colorectal carcinoma
    • Werther K, Christensen IJ, Nielsen HJ, Danish RANX05 Colorectal Cancer Study Group. Prognostic impact of matched preoperative plasma and serum VEGF in patients with primary colorectal carcinoma. Br J Cancer (2002) 86:417-23. doi:10.1038/sj.bjc.6600075
    • (2002) Br J Cancer , vol.86 , pp. 417-423
    • Werther, K.1    Christensen, I.J.2    Nielsen, H.J.3
  • 260
    • 78650407055 scopus 로고    scopus 로고
    • VEGF receptor signaling links inflammation and tumorigenesis in colitis-associated cancer
    • Waldner MJ, Wirtz S, Jefremow A, Warntjen M, Neufert C, Atreya R, et al. VEGF receptor signaling links inflammation and tumorigenesis in colitis-associated cancer. J Exp Med (2010) 207:2855-68. doi:10.1084/jem.20100438
    • (2010) J Exp Med , vol.207 , pp. 2855-2868
    • Waldner, M.J.1    Wirtz, S.2    Jefremow, A.3    Warntjen, M.4    Neufert, C.5    Atreya, R.6
  • 261
    • 34547519439 scopus 로고    scopus 로고
    • Inhibition of VEGF-A prevents the angiogenic switch and results in increased survival of Apc+/min mice
    • Korsisaari N, Kasman IM, Forrest WF, Pal N, Bai W, Fuh G, et al. Inhibition of VEGF-A prevents the angiogenic switch and results in increased survival of Apc+/min mice. Proc Natl Acad Sci U S A (2007) 104:10625-30. doi:10.1073/pnas.0704213104
    • (2007) Proc Natl Acad Sci U S A , vol.104 , pp. 10625-10630
    • Korsisaari, N.1    Kasman, I.M.2    Forrest, W.F.3    Pal, N.4    Bai, W.5    Fuh, G.6
  • 262
    • 33749549907 scopus 로고    scopus 로고
    • Inhibiting vascular endothelial growth factor receptor-2 signaling reduces tumor burden in the ApcMin/+ mouse model of early intestinal cancer
    • Goodlad RA, Ryan AJ, Wedge SR, Pyrah IT, Alferez D, Poulsom R, et al. Inhibiting vascular endothelial growth factor receptor-2 signaling reduces tumor burden in the ApcMin/+ mouse model of early intestinal cancer. Carcinogenesis (2006) 27:2133-9. doi:10.1093/carcin/bgl113
    • (2006) Carcinogenesis , vol.27 , pp. 2133-2139
    • Goodlad, R.A.1    Ryan, A.J.2    Wedge, S.R.3    Pyrah, I.T.4    Alferez, D.5    Poulsom, R.6
  • 263
    • 66149086950 scopus 로고    scopus 로고
    • Positive and negative modulation of angiogenesis by VEGFR1 ligands
    • Cao Y. Positive and negative modulation of angiogenesis by VEGFR1 ligands. Sci Signal (2009) 2:re1. doi:10.1126/scisignal.259re1
    • (2009) Sci Signal , vol.2
    • Cao, Y.1
  • 264
    • 0037531794 scopus 로고    scopus 로고
    • The angiogenic switch for vascular endothelial growth factor (VEGF)-A, VEGF-B, VEGF-C, and VEGF-D in the adenoma-carcinoma sequence during colorectal cancer progression
    • Hanrahan V, Currie MJ, Gunningham SP, Morrin HR, Scott PA, Robinson BA, et al. The angiogenic switch for vascular endothelial growth factor (VEGF)-A, VEGF-B, VEGF-C, and VEGF-D in the adenoma-carcinoma sequence during colorectal cancer progression. J Pathol (2003) 200:183-94. doi:10.1002/path.1339
    • (2003) J Pathol , vol.200 , pp. 183-194
    • Hanrahan, V.1    Currie, M.J.2    Gunningham, S.P.3    Morrin, H.R.4    Scott, P.A.5    Robinson, B.A.6
  • 265
    • 73349124764 scopus 로고    scopus 로고
    • Vascular endothelial growth factor receptor-1 is synthetic lethal to aberrant beta-catenin activation in colon cancer
    • Naik S, Dothager RS, Marasa J, Lewis CL, Piwnica-Worms D. Vascular endothelial growth factor receptor-1 is synthetic lethal to aberrant beta-catenin activation in colon cancer. Clin Cancer Res (2009) 15:7529-37. doi:10.1158/1078-0432.CCR-09-0336
    • (2009) Clin Cancer Res , vol.15 , pp. 7529-7537
    • Naik, S.1    Dothager, R.S.2    Marasa, J.3    Lewis, C.L.4    Piwnica-Worms, D.5
  • 266
    • 0038745735 scopus 로고    scopus 로고
    • Beta-catenin regulates vascular endothelial growth factor expression in colon cancer
    • Easwaran V, Lee SH, Inge L, Guo L, Goldbeck C, Garrett E, et al. Beta-catenin regulates vascular endothelial growth factor expression in colon cancer. Cancer Res (2003) 63:3145-53
    • (2003) Cancer Res , vol.63 , pp. 3145-3153
    • Easwaran, V.1    Lee, S.H.2    Inge, L.3    Guo, L.4    Goldbeck, C.5    Garrett, E.6
  • 267
    • 33845337061 scopus 로고    scopus 로고
    • Tumour-associated angiogenesis in human colorectal cancer
    • Rmali KA, Puntis MC, Jiang WG. Tumour-associated angiogenesis in human colorectal cancer. Colorectal Dis (2007) 9:3-14. doi:10.1111/j.1463-1318.2006.01089.x
    • (2007) Colorectal Dis , vol.9 , pp. 3-14
    • Rmali, K.A.1    Puntis, M.C.2    Jiang, W.G.3
  • 269
    • 85056746732 scopus 로고    scopus 로고
    • Inflammatory response in serrated precursor lesions of the colon classified according to WHO entities, clinical parameters and phenotype-genotype correlation
    • Rau TT, Atreya R, Aust D, Baretton G, Eck M, Erlenbach-Wünsch K, et al. Inflammatory response in serrated precursor lesions of the colon classified according to WHO entities, clinical parameters and phenotype-genotype correlation. J Pathol Clin Res (2016). doi:10.1002/cjp2.41
    • (2016) J Pathol Clin Res
    • Rau, T.T.1    Atreya, R.2    Aust, D.3    Baretton, G.4    Eck, M.5    Erlenbach-Wünsch, K.6
  • 270
    • 84872370561 scopus 로고    scopus 로고
    • Loss of p53 in enterocytes generates an inflammatory microenvironment enabling invasion and lymph node metastasis of carcinogen-induced colorectal tumors
    • Schwitalla S, Ziegler PK, Horst D, Becker V, Kerle I, Begus-Nahrmann Y, et al. Loss of p53 in enterocytes generates an inflammatory microenvironment enabling invasion and lymph node metastasis of carcinogen-induced colorectal tumors. Cancer Cell (2013) 23:93-106. doi:10.1016/j.ccr.2012.11.014
    • (2013) Cancer Cell , vol.23 , pp. 93-106
    • Schwitalla, S.1    Ziegler, P.K.2    Horst, D.3    Becker, V.4    Kerle, I.5    Begus-Nahrmann, Y.6
  • 271
    • 84897561550 scopus 로고    scopus 로고
    • IL-6R/STAT3/miR-34a feedback loop promotes EMT-mediated colorectal cancer invasion and metastasis
    • Rokavec M, Oner MG, Li H, Jackstadt R, Jiang L, Lodygin D, et al. IL-6R/STAT3/miR-34a feedback loop promotes EMT-mediated colorectal cancer invasion and metastasis. J Clin Invest (2014) 124:1853-67. doi:10.1172/JCI73531
    • (2014) J Clin Invest , vol.124 , pp. 1853-1867
    • Rokavec, M.1    Oner, M.G.2    Li, H.3    Jackstadt, R.4    Jiang, L.5    Lodygin, D.6
  • 272
    • 84877823153 scopus 로고    scopus 로고
    • Mutant p53 prolongs NF-kappaB activation and promotes chronic inflammation and inflammation-associated colorectal cancer
    • Cooks T, Pateras IS, Tarcic O, Solomon H, Schetter AJ, Wilder S, et al. Mutant p53 prolongs NF-kappaB activation and promotes chronic inflammation and inflammation-associated colorectal cancer. Cancer Cell (2013) 23:634-46. doi:10.1016/j.ccr.2013.03.022
    • (2013) Cancer Cell , vol.23 , pp. 634-646
    • Cooks, T.1    Pateras, I.S.2    Tarcic, O.3    Solomon, H.4    Schetter, A.J.5    Wilder, S.6
  • 273
    • 84867103263 scopus 로고    scopus 로고
    • Chronic intestinal inflammation: inflammatory bowel disease and colitis-associated colon cancer
    • Rubin DC, Shaker A, Levin MS. Chronic intestinal inflammation: inflammatory bowel disease and colitis-associated colon cancer. Front Immunol (2012) 3:107. doi:10.3389/fimmu.2012.00107
    • (2012) Front Immunol , vol.3 , pp. 107
    • Rubin, D.C.1    Shaker, A.2    Levin, M.S.3
  • 274
    • 84888227624 scopus 로고    scopus 로고
    • Myeloid-derived suppressor cells in the inflammatory bowel diseases
    • Ostanin DV, Bhattacharya D. Myeloid-derived suppressor cells in the inflammatory bowel diseases. Inflamm Bowel Dis (2013) 19:2468-77. doi:10.1097/MIB.0b013e3182902b11
    • (2013) Inflamm Bowel Dis , vol.19 , pp. 2468-2477
    • Ostanin, D.V.1    Bhattacharya, D.2
  • 276
    • 65249138393 scopus 로고    scopus 로고
    • Myeloid-derived suppressor cells: linking inflammation and cancer
    • Ostrand-Rosenberg S, Sinha P. Myeloid-derived suppressor cells: linking inflammation and cancer. J Immunol (2009) 182:4499-506. doi:10.4049/jimmunol.0802740
    • (2009) J Immunol , vol.182 , pp. 4499-4506
    • Ostrand-Rosenberg, S.1    Sinha, P.2
  • 277
    • 0026689558 scopus 로고
    • The origin and function of tumor-associated macrophages
    • Mantovani A, Bottazzi B, Colotta F, Sozzani S, Ruco L. The origin and function of tumor-associated macrophages. Immunol Today (1992) 13:265-70. doi:10.1016/0167-5699(92)90008-U
    • (1992) Immunol Today , vol.13 , pp. 265-270
    • Mantovani, A.1    Bottazzi, B.2    Colotta, F.3    Sozzani, S.4    Ruco, L.5
  • 278
    • 67650151005 scopus 로고    scopus 로고
    • Cancer-related inflammation, the seventh hallmark of cancer: links to genetic instability
    • Colotta F, Allavena P, Sica A, Garlanda C, Mantovani A. Cancer-related inflammation, the seventh hallmark of cancer: links to genetic instability. Carcinogenesis (2009) 30:1073-81. doi:10.1093/carcin/bgp127
    • (2009) Carcinogenesis , vol.30 , pp. 1073-1081
    • Colotta, F.1    Allavena, P.2    Sica, A.3    Garlanda, C.4    Mantovani, A.5
  • 279
    • 77950950894 scopus 로고    scopus 로고
    • Macrophage diversity enhances tumor progression and metastasis
    • Qian BZ, Pollard JW. Macrophage diversity enhances tumor progression and metastasis. Cell (2010) 141:39-51. doi:10.1016/j.cell.2010.03.014
    • (2010) Cell , vol.141 , pp. 39-51
    • Qian, B.Z.1    Pollard, J.W.2
  • 280
    • 53549102755 scopus 로고    scopus 로고
    • The tumor microenvironment and its role in promoting tumor growth
    • Whiteside TL. The tumor microenvironment and its role in promoting tumor growth. Oncogene (2008) 27:5904-12. doi:10.1038/onc.2008.271
    • (2008) Oncogene , vol.27 , pp. 5904-5912
    • Whiteside, T.L.1
  • 281
    • 77950346282 scopus 로고    scopus 로고
    • Immunity, inflammation, and cancer
    • Grivennikov SI, Greten FR, Karin M. Immunity, inflammation, and cancer. Cell (2010) 140:883-99. doi:10.1016/j.cell.2010.01.025
    • (2010) Cell , vol.140 , pp. 883-899
    • Grivennikov, S.I.1    Greten, F.R.2    Karin, M.3
  • 282
    • 0004753309 scopus 로고    scopus 로고
    • Phase II trial of intravenous endotoxin in patients with colorectal and non-small cell lung cancer
    • Otto F, Schmid P, Mackensen A, Wehr U, Seiz A, Braun M, et al. Phase II trial of intravenous endotoxin in patients with colorectal and non-small cell lung cancer. Eur J Cancer (1996) 32A:1712-8. doi:10.1016/0959-8049(96)00186-4
    • (1996) Eur J Cancer , vol.32A , pp. 1712-1718
    • Otto, F.1    Schmid, P.2    Mackensen, A.3    Wehr, U.4    Seiz, A.5    Braun, M.6
  • 283
    • 84928062583 scopus 로고    scopus 로고
    • Immune checkpoint blockade: a common denominator approach to cancer therapy
    • Topalian SL, Drake CG, Pardoll DM. Immune checkpoint blockade: a common denominator approach to cancer therapy. Cancer Cell (2015) 27:450-61. doi:10.1016/j.ccell.2015.03.001
    • (2015) Cancer Cell , vol.27 , pp. 450-461
    • Topalian, S.L.1    Drake, C.G.2    Pardoll, D.M.3
  • 284
    • 58349090027 scopus 로고    scopus 로고
    • Potentiating endogenous antitumor immunity to prostate cancer through combination immunotherapy with CTLA4 blockade and GM-CSF
    • Fong L, Kwek SS, O'Brien S, Kavanagh B, McNeel DG, Weinberg V, et al. Potentiating endogenous antitumor immunity to prostate cancer through combination immunotherapy with CTLA4 blockade and GM-CSF. Cancer Res (2009) 69:609-15. doi:10.1158/0008-5472.CAN-08-3529
    • (2009) Cancer Res , vol.69 , pp. 609-615
    • Fong, L.1    Kwek, S.S.2    O'Brien, S.3    Kavanagh, B.4    McNeel, D.G.5    Weinberg, V.6
  • 285
    • 84898973055 scopus 로고    scopus 로고
    • Survival, durable tumor remission, and long-term safety in patients with advanced melanoma receiving nivolumab
    • Topalian SL, Sznol M, McDermott DF, Kluger HM, Carvajal RD, Sharfman WH, et al. Survival, durable tumor remission, and long-term safety in patients with advanced melanoma receiving nivolumab. J Clin Oncol (2014) 32:1020-30. doi:10.1200/JCO.2013.53.0105
    • (2014) J Clin Oncol , vol.32 , pp. 1020-1030
    • Topalian, S.L.1    Sznol, M.2    McDermott, D.F.3    Kluger, H.M.4    Carvajal, R.D.5    Sharfman, W.H.6
  • 286
    • 84942824207 scopus 로고    scopus 로고
    • An immunogenomic stratification of colorectal cancer: implications for development of targeted immunotherapy
    • Lal N, Beggs AD, Willcox BE, Middleton GW. An immunogenomic stratification of colorectal cancer: implications for development of targeted immunotherapy. Oncoimmunology (2015) 4:e976052. doi:10.4161/2162402X.2014.976052
    • (2015) Oncoimmunology , vol.4
    • Lal, N.1    Beggs, A.D.2    Willcox, B.E.3    Middleton, G.W.4
  • 287
    • 84922369377 scopus 로고    scopus 로고
    • The vigorous immune microenvironment of microsatellite instable colon cancer is balanced by multiple counter-inhibitory checkpoints
    • Llosa NJ, Cruise M, Tam A, Wicks EC, Hechenbleikner EM, Taube JM, et al. The vigorous immune microenvironment of microsatellite instable colon cancer is balanced by multiple counter-inhibitory checkpoints. Cancer Discov (2015) 5:43-51. doi:10.1158/2159-8290.CD-14-0863
    • (2015) Cancer Discov , vol.5 , pp. 43-51
    • Llosa, N.J.1    Cruise, M.2    Tam, A.3    Wicks, E.C.4    Hechenbleikner, E.M.5    Taube, J.M.6
  • 288
    • 77955292303 scopus 로고    scopus 로고
    • Phase II study of the anti-cytotoxic T-lymphocyte-associated antigen 4 monoclonal antibody, tremelimumab, in patients with refractory metastatic colorectal cancer
    • Chung KY, Gore I, Fong L, Venook A, Beck SB, Dorazio P, et al. Phase II study of the anti-cytotoxic T-lymphocyte-associated antigen 4 monoclonal antibody, tremelimumab, in patients with refractory metastatic colorectal cancer. J Clin Oncol (2010) 28:3485-90. doi:10.1200/JCO.2010.28.3994
    • (2010) J Clin Oncol , vol.28 , pp. 3485-3490
    • Chung, K.Y.1    Gore, I.2    Fong, L.3    Venook, A.4    Beck, S.B.5    Dorazio, P.6
  • 289
    • 84862903106 scopus 로고    scopus 로고
    • Safety and activity of anti-PD-L1 antibody in patients with advanced cancer
    • Brahmer JR, Tykodi SS, Chow LQ, Hwu WJ, Topalian SL, Hwu P, et al. Safety and activity of anti-PD-L1 antibody in patients with advanced cancer. N Engl J Med (2012) 366:2455-65. doi:10.1056/NEJMoa1200694
    • (2012) N Engl J Med , vol.366 , pp. 2455-2465
    • Brahmer, J.R.1    Tykodi, S.S.2    Chow, L.Q.3    Hwu, W.J.4    Topalian, S.L.5    Hwu, P.6
  • 290
    • 79551521053 scopus 로고    scopus 로고
    • Phase III trial assessing bevacizumab in stages II and III carcinoma of the colon: results of NSABP protocol C-08
    • Allegra CJ, Yothers G, O'Connell MJ, Sharif S, Petrelli NJ, Colangelo LH, et al. Phase III trial assessing bevacizumab in stages II and III carcinoma of the colon: results of NSABP protocol C-08. J Clin Oncol (2011) 29:11-6. doi:10.1200/JCO.2010.30.0855
    • (2011) J Clin Oncol , vol.29 , pp. 11-16
    • Allegra, C.J.1    Yothers, G.2    O'Connell, M.J.3    Sharif, S.4    Petrelli, N.J.5    Colangelo, L.H.6
  • 291
    • 84908139591 scopus 로고    scopus 로고
    • Initial therapy with FOLFOXIRI and bevacizumab for metastatic colorectal cancer
    • Loupakis F, Cremolini C, Masi G, Lonardi S, Zagonel V, Salvatore L, et al. Initial therapy with FOLFOXIRI and bevacizumab for metastatic colorectal cancer. N Engl J Med (2014) 371:1609-18. doi:10.1056/NEJMoa1403108
    • (2014) N Engl J Med , vol.371 , pp. 1609-1618
    • Loupakis, F.1    Cremolini, C.2    Masi, G.3    Lonardi, S.4    Zagonel, V.5    Salvatore, L.6
  • 292
    • 34548732637 scopus 로고    scopus 로고
    • A placebo-controlled double blind trial of etanercept for the cancer anorexia/weight loss syndrome: results from N00C1 from the North Central Cancer Treatment Group
    • Jatoi A, Dakhil SR, Nguyen PL, Sloan JA, Kugler JW, Rowland KM Jr, et al. A placebo-controlled double blind trial of etanercept for the cancer anorexia/weight loss syndrome: results from N00C1 from the North Central Cancer Treatment Group. Cancer (2007) 110:1396-403. doi:10.1002/cncr.22944
    • (2007) Cancer , vol.110 , pp. 1396-1403
    • Jatoi, A.1    Dakhil, S.R.2    Nguyen, P.L.3    Sloan, J.A.4    Kugler, J.W.5    Rowland, K.M.6
  • 293
    • 84898967209 scopus 로고    scopus 로고
    • A phase I/II, multiple-dose, dose-escalation study of siltuximab, an anti-interleukin-6 monoclonal antibody, in patients with advanced solid tumors
    • Angevin E, Tabernero J, Elez E, Cohen SJ, Bahleda R, van Laethem JL, et al. A phase I/II, multiple-dose, dose-escalation study of siltuximab, an anti-interleukin-6 monoclonal antibody, in patients with advanced solid tumors. Clin Cancer Res (2014) 20:2192-204. doi:10.1158/1078-0432.CCR-13-2200
    • (2014) Clin Cancer Res , vol.20 , pp. 2192-2204
    • Angevin, E.1    Tabernero, J.2    Elez, E.3    Cohen, S.J.4    Bahleda, R.5    van Laethem, J.L.6
  • 294
    • 78449244037 scopus 로고    scopus 로고
    • The emerging toxicity profiles of anti-CTLA-4 antibodies across clinical indications
    • Di Giacomo AM, Biagioli M, Maio M. The emerging toxicity profiles of anti-CTLA-4 antibodies across clinical indications. Semin Oncol (2010) 37:499-507. doi:10.1053/j.seminoncol.2010.09.007
    • (2010) Semin Oncol , vol.37 , pp. 499-507
    • Di Giacomo, A.M.1    Biagioli, M.2    Maio, M.3
  • 296
    • 84924690678 scopus 로고    scopus 로고
    • Gut microbiome development along the colorectal adenoma-carcinoma sequence
    • Feng Q, Liang S, Jia H, Stadlmayr A, Tang L, Lan Z, et al. Gut microbiome development along the colorectal adenoma-carcinoma sequence. Nat Commun (2015) 6:6528. doi:10.1038/ncomms7528
    • (2015) Nat Commun , vol.6 , pp. 6528
    • Feng, Q.1    Liang, S.2    Jia, H.3    Stadlmayr, A.4    Tang, L.5    Lan, Z.6
  • 297
    • 84926436561 scopus 로고    scopus 로고
    • Microbiota disbiosis is associated with colorectal cancer
    • Gao Z, Guo B, Gao R, Zhu Q, Qin H. Microbiota disbiosis is associated with colorectal cancer. Front Microbiol (2015) 6:20. doi:10.3389/fmicb.2015.00020
    • (2015) Front Microbiol , vol.6 , pp. 20
    • Gao, Z.1    Guo, B.2    Gao, R.3    Zhu, Q.4    Qin, H.5
  • 298
    • 70350343544 scopus 로고    scopus 로고
    • Induction of intestinal Th17 cells by segmented filamentous bacteria
    • Ivanov II, Atarashi K, Manel N, Brodie EL, Shima T, Karaoz U, et al. Induction of intestinal Th17 cells by segmented filamentous bacteria. Cell (2009) 139:485-98. doi:10.1016/j.cell.2009.09.033
    • (2009) Cell , vol.139 , pp. 485-498
    • Ivanov, I.I.1    Atarashi, K.2    Manel, N.3    Brodie, E.L.4    Shima, T.5    Karaoz, U.6
  • 299
    • 85027947787 scopus 로고    scopus 로고
    • Induction of colonic regulatory T cells by indigenous Clostridium species
    • Atarashi K, Tanoue T, Shima T, Imaoka A, Kuwahara T, Momose Y, et al. Induction of colonic regulatory T cells by indigenous Clostridium species. Science (2011) 331:337-41. doi:10.1126/science.1198469
    • (2011) Science , vol.331 , pp. 337-341
    • Atarashi, K.1    Tanoue, T.2    Shima, T.3    Imaoka, A.4    Kuwahara, T.5    Momose, Y.6
  • 300
    • 0002647979 scopus 로고    scopus 로고
    • Non-pathogenic bacteria elicit a differential cytokine response by intestinal epithelial cell/leucocyte co-cultures
    • Haller D, Bode C, Hammes WP, Pfeifer AM, Schiffrin EJ, Blum S. Non-pathogenic bacteria elicit a differential cytokine response by intestinal epithelial cell/leucocyte co-cultures. Gut (2000) 47:79-87. doi:10.1136/gut.47.1.79
    • (2000) Gut , vol.47 , pp. 79-87
    • Haller, D.1    Bode, C.2    Hammes, W.P.3    Pfeifer, A.M.4    Schiffrin, E.J.5    Blum, S.6
  • 301
    • 78650166351 scopus 로고    scopus 로고
    • Induction of cytokine formation by human intestinal bacteria in gut epithelial cell lines
    • Bahrami B, Macfarlane S, Macfarlane GT. Induction of cytokine formation by human intestinal bacteria in gut epithelial cell lines. J Appl Microbiol (2011) 110:353-63. doi:10.1111/j.1365-2672.2010.04889.x
    • (2011) J Appl Microbiol , vol.110 , pp. 353-363
    • Bahrami, B.1    Macfarlane, S.2    Macfarlane, G.T.3
  • 302
    • 84892476369 scopus 로고    scopus 로고
    • Alterations in the microbiota drive interleukin-17C production from intestinal epithelial cells to promote tumorigenesis
    • Song X, Gao H, Lin Y, Yao Y, Zhu S, Wang J, et al. Alterations in the microbiota drive interleukin-17C production from intestinal epithelial cells to promote tumorigenesis. Immunity (2014) 40:140-52. doi:10.1016/j.immuni.2013.11.018
    • (2014) Immunity , vol.40 , pp. 140-152
    • Song, X.1    Gao, H.2    Lin, Y.3    Yao, Y.4    Zhu, S.5    Wang, J.6
  • 304
    • 84892449521 scopus 로고    scopus 로고
    • Activation of Gpr109a, receptor for niacin and the commensal metabolite butyrate, suppresses colonic inflammation and carcinogenesis
    • Singh N, Gurav A, Sivaprakasam S, Brady E, Padia R, Shi H, et al. Activation of Gpr109a, receptor for niacin and the commensal metabolite butyrate, suppresses colonic inflammation and carcinogenesis. Immunity (2014) 40:128-39. doi:10.1016/j.immuni.2013.12.007
    • (2014) Immunity , vol.40 , pp. 128-139
    • Singh, N.1    Gurav, A.2    Sivaprakasam, S.3    Brady, E.4    Padia, R.5    Shi, H.6
  • 305
    • 84948451779 scopus 로고    scopus 로고
    • Commensal Bifidobacterium promotes antitumor immunity and facilitates anti-PD-L1 efficacy
    • Sivan A, Corrales L, Hubert N, Williams JB, Aquino-Michaels K, Earley ZM, et al. Commensal Bifidobacterium promotes antitumor immunity and facilitates anti-PD-L1 efficacy. Science (2015) 350:1084-9. doi:10.1126/science.aac4255
    • (2015) Science , vol.350 , pp. 1084-1089
    • Sivan, A.1    Corrales, L.2    Hubert, N.3    Williams, J.B.4    Aquino-Michaels, K.5    Earley, Z.M.6
  • 306
    • 84948461699 scopus 로고    scopus 로고
    • Anticancer immunotherapy by CTLA-4 blockade relies on the gut microbiota
    • Vetizou M, Pitt JM, Daillere R, Lepage P, Waldschmitt N, Flament C, et al. Anticancer immunotherapy by CTLA-4 blockade relies on the gut microbiota. Science (2015) 350:1079-84. doi:10.1126/science.aad1329
    • (2015) Science , vol.350 , pp. 1079-1084
    • Vetizou, M.1    Pitt, J.M.2    Daillere, R.3    Lepage, P.4    Waldschmitt, N.5    Flament, C.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.