-
1
-
-
78049485263
-
Estimates of worldwide burden of cancer in 2008: GLOBOCAN 2008
-
Ferlay J, Shin HR, Bray F, Forman D, Mathers C, Parkin DM. Estimates of worldwide burden of cancer in 2008: GLOBOCAN 2008. Int J Cancer (2010) 127:2893-917. doi:10.1002/ijc.25516
-
(2010)
Int J Cancer
, vol.127
, pp. 2893-2917
-
-
Ferlay, J.1
Shin, H.R.2
Bray, F.3
Forman, D.4
Mathers, C.5
Parkin, D.M.6
-
2
-
-
84941364888
-
Genetic architecture of colorectal cancer
-
Peters U, Bien S, Zubair N. Genetic architecture of colorectal cancer. Gut (2015) 64:1623-36. doi:10.1136/gutjnl-2013-306705
-
(2015)
Gut
, vol.64
, pp. 1623-1636
-
-
Peters, U.1
Bien, S.2
Zubair, N.3
-
3
-
-
4944240144
-
Genetic predisposition to colorectal cancer
-
de la Chapelle A. Genetic predisposition to colorectal cancer. Nat Rev Cancer (2004) 4:769-80. doi:10.1038/nrc1453
-
(2004)
Nat Rev Cancer
, vol.4
, pp. 769-780
-
-
de la Chapelle, A.1
-
4
-
-
80052049486
-
Molecular genetic analysis of 103 sporadic colorectal tumours in Czech patients
-
Vasovcak P, Pavlikova K, Sedlacek Z, Skapa P, Kouda M, Hoch J, et al. Molecular genetic analysis of 103 sporadic colorectal tumours in Czech patients. PLoS One (2011) 6:e24114. doi:10.1371/journal.pone.0024114
-
(2011)
PLoS One
, vol.6
-
-
Vasovcak, P.1
Pavlikova, K.2
Sedlacek, Z.3
Skapa, P.4
Kouda, M.5
Hoch, J.6
-
5
-
-
84890472864
-
Molecular pathways involved in colorectal cancer: implications for disease behavior and prevention
-
Colussi D, Brandi G, Bazzoli F, Ricciardiello L. Molecular pathways involved in colorectal cancer: implications for disease behavior and prevention. Int J Mol Sci (2013) 14:16365-85. doi:10.3390/ijms140816365
-
(2013)
Int J Mol Sci
, vol.14
, pp. 16365-16385
-
-
Colussi, D.1
Brandi, G.2
Bazzoli, F.3
Ricciardiello, L.4
-
6
-
-
78649639011
-
The tumor microenvironment in colorectal carcinogenesis
-
Peddareddigari VG, Wang D, Dubois RN. The tumor microenvironment in colorectal carcinogenesis. Cancer Microenviron (2010) 3:149-66. doi:10.1007/s12307-010-0038-3
-
(2010)
Cancer Microenviron
, vol.3
, pp. 149-166
-
-
Peddareddigari, V.G.1
Wang, D.2
Dubois, R.N.3
-
7
-
-
84869021181
-
Dependency of colorectal cancer on a TGF-beta-driven program in stromal cells for metastasis initiation
-
Calon A, Espinet E, Palomo-Ponce S, Tauriello DV, Iglesias M, Cespedes MV, et al. Dependency of colorectal cancer on a TGF-beta-driven program in stromal cells for metastasis initiation. Cancer Cell (2012) 22:571-84. doi:10.1016/j.ccr.2012.08.013
-
(2012)
Cancer Cell
, vol.22
, pp. 571-584
-
-
Calon, A.1
Espinet, E.2
Palomo-Ponce, S.3
Tauriello, D.V.4
Iglesias, M.5
Cespedes, M.V.6
-
8
-
-
84873728505
-
Endothelial cells promote the colorectal cancer stem cell phenotype through a soluble form of Jagged-1
-
Lu J, Ye X, Fan F, Xia L, Bhattacharya R, Bellister S, et al. Endothelial cells promote the colorectal cancer stem cell phenotype through a soluble form of Jagged-1. Cancer Cell (2013) 23:171-85. doi:10.1016/j.ccr.2012.12.021
-
(2013)
Cancer Cell
, vol.23
, pp. 171-185
-
-
Lu, J.1
Ye, X.2
Fan, F.3
Xia, L.4
Bhattacharya, R.5
Bellister, S.6
-
9
-
-
84925818452
-
Stromal gene expression defines poor-prognosis subtypes in colorectal cancer
-
Calon A, Lonardo E, Berenguer-Llergo A, Espinet E, Hernando-Momblona X, Iglesias M, et al. Stromal gene expression defines poor-prognosis subtypes in colorectal cancer. Nat Genet (2015) 47:320-9. doi:10.1038/ng.3225
-
(2015)
Nat Genet
, vol.47
, pp. 320-329
-
-
Calon, A.1
Lonardo, E.2
Berenguer-Llergo, A.3
Espinet, E.4
Hernando-Momblona, X.5
Iglesias, M.6
-
10
-
-
0022453271
-
The grading of rectal cancer: historical perspectives and a multivariate analysis of 447 cases
-
Jass JR, Atkin WS, Cuzick J, Bussey HJ, Morson BC, Northover JM, et al. The grading of rectal cancer: historical perspectives and a multivariate analysis of 447 cases. Histopathology (1986) 10:437-59. doi:10.1111/j.1365-2559.1986.tb02497.x
-
(1986)
Histopathology
, vol.10
, pp. 437-459
-
-
Jass, J.R.1
Atkin, W.S.2
Cuzick, J.3
Bussey, H.J.4
Morson, B.C.5
Northover, J.M.6
-
11
-
-
27744568370
-
Inflammation and prognosis in colorectal cancer
-
Klintrup K, Makinen JM, Kauppila S, Vare PO, Melkko J, Tuominen H, et al. Inflammation and prognosis in colorectal cancer. Eur J Cancer (2005) 41:2645-54. doi:10.1016/j.ejca.2005.07.017
-
(2005)
Eur J Cancer
, vol.41
, pp. 2645-2654
-
-
Klintrup, K.1
Makinen, J.M.2
Kauppila, S.3
Vare, P.O.4
Melkko, J.5
Tuominen, H.6
-
12
-
-
33749319703
-
Type, density, and location of immune cells within human colorectal tumors predict clinical outcome
-
Galon J, Costes A, Sanchez-Cabo F, Kirilovsky A, Mlecnik B, Lagorce-Pages C, et al. Type, density, and location of immune cells within human colorectal tumors predict clinical outcome. Science (2006) 313:1960-4. doi:10.1126/science.1129139
-
(2006)
Science
, vol.313
, pp. 1960-1964
-
-
Galon, J.1
Costes, A.2
Sanchez-Cabo, F.3
Kirilovsky, A.4
Mlecnik, B.5
Lagorce-Pages, C.6
-
13
-
-
84866852663
-
Cancer classification using the Immunoscore: a worldwide task force
-
Galon J, Pages F, Marincola FM, Angell HK, Thurin M, Lugli A, et al. Cancer classification using the Immunoscore: a worldwide task force. J Transl Med (2012) 10:205. doi:10.1186/1479-5876-10-205
-
(2012)
J Transl Med
, vol.10
, pp. 205
-
-
Galon, J.1
Pages, F.2
Marincola, F.M.3
Angell, H.K.4
Thurin, M.5
Lugli, A.6
-
14
-
-
84890280907
-
Towards the introduction of the 'Immunoscore' in the classification of malignant tumours
-
Galon J, Mlecnik B, Bindea G, Angell HK, Berger A, Lagorce C, et al. Towards the introduction of the 'Immunoscore' in the classification of malignant tumours. J Pathol (2014) 232:199-209. doi:10.1002/path.4287
-
(2014)
J Pathol
, vol.232
, pp. 199-209
-
-
Galon, J.1
Mlecnik, B.2
Bindea, G.3
Angell, H.K.4
Berger, A.5
Lagorce, C.6
-
15
-
-
79951815749
-
Clinical impact of different classes of infiltrating T cytotoxic and helper cells (Th1, Th2, Treg, Th17) in patients with colorectal cancer
-
Tosolini M, Kirilovsky A, Mlecnik B, Fredriksen T, Mauger S, Bindea G, et al. Clinical impact of different classes of infiltrating T cytotoxic and helper cells (Th1, Th2, Treg, Th17) in patients with colorectal cancer. Cancer Res (2011) 71:1263-71. doi:10.1158/0008-5472.CAN-10-2907
-
(2011)
Cancer Res
, vol.71
, pp. 1263-1271
-
-
Tosolini, M.1
Kirilovsky, A.2
Mlecnik, B.3
Fredriksen, T.4
Mauger, S.5
Bindea, G.6
-
16
-
-
84869096388
-
Stage-dependent alterations of the serum cytokine pattern in colorectal carcinoma
-
Kantola T, Klintrup K, Vayrynen JP, Vornanen J, Bloigu R, Karhu T, et al. Stage-dependent alterations of the serum cytokine pattern in colorectal carcinoma. Br J Cancer (2012) 107:1729-36. doi:10.1038/bjc.2012.456
-
(2012)
Br J Cancer
, vol.107
, pp. 1729-1736
-
-
Kantola, T.1
Klintrup, K.2
Vayrynen, J.P.3
Vornanen, J.4
Bloigu, R.5
Karhu, T.6
-
18
-
-
84880037004
-
Profiles of circulating inflammatory cytokines in colorectal cancer (CRC), high cancer risk conditions, and health are distinct. Possible implications for CRC screening and surveillance
-
Krzystek-Korpacka M, Diakowska D, Kapturkiewicz B, Bebenek M, Gamian A. Profiles of circulating inflammatory cytokines in colorectal cancer (CRC), high cancer risk conditions, and health are distinct. Possible implications for CRC screening and surveillance. Cancer Lett (2013) 337:107-14. doi:10.1016/j.canlet.2013.05.033
-
(2013)
Cancer Lett
, vol.337
, pp. 107-114
-
-
Krzystek-Korpacka, M.1
Diakowska, D.2
Kapturkiewicz, B.3
Bebenek, M.4
Gamian, A.5
-
19
-
-
84899050715
-
Functional network pipeline reveals genetic determinants associated with in situ lymphocyte proliferation and survival of cancer patients
-
Mlecnik B, Bindea G, Angell HK, Sasso MS, Obenauf AC, Fredriksen T, et al. Functional network pipeline reveals genetic determinants associated with in situ lymphocyte proliferation and survival of cancer patients. Sci Transl Med (2014) 6:228ra237. doi:10.1126/scitranslmed.3007240
-
(2014)
Sci Transl Med
, vol.6
-
-
Mlecnik, B.1
Bindea, G.2
Angell, H.K.3
Sasso, M.S.4
Obenauf, A.C.5
Fredriksen, T.6
-
20
-
-
84922132326
-
Tumor-specific cytotoxic T lymphocyte activity determines colorectal cancer patient prognosis
-
Reissfelder C, Stamova S, Gossmann C, Braun M, Bonertz A, Walliczek U, et al. Tumor-specific cytotoxic T lymphocyte activity determines colorectal cancer patient prognosis. J Clin Invest (2015) 125:739-51. doi:10.1172/JCI74894
-
(2015)
J Clin Invest
, vol.125
, pp. 739-751
-
-
Reissfelder, C.1
Stamova, S.2
Gossmann, C.3
Braun, M.4
Bonertz, A.5
Walliczek, U.6
-
21
-
-
84868613705
-
Adenoma-linked barrier defects and microbial products drive IL-23/IL-17-mediated tumour growth
-
Grivennikov SI, Wang K, Mucida D, Stewart CA, Schnabl B, Jauch D, et al. Adenoma-linked barrier defects and microbial products drive IL-23/IL-17-mediated tumour growth. Nature (2012) 491:254-8. doi:10.1038/nature11465
-
(2012)
Nature
, vol.491
, pp. 254-258
-
-
Grivennikov, S.I.1
Wang, K.2
Mucida, D.3
Stewart, C.A.4
Schnabl, B.5
Jauch, D.6
-
22
-
-
33644759372
-
The role of interleukin 1 in growth and metastasis of human cancer xenografts
-
Elaraj DM, Weinreich DM, Varghese S, Puhlmann M, Hewitt SM, Carroll NM, et al. The role of interleukin 1 in growth and metastasis of human cancer xenografts. Clin Cancer Res (2006) 12:1088-96. doi:10.1158/1078-0432.CCR-05-1603
-
(2006)
Clin Cancer Res
, vol.12
, pp. 1088-1096
-
-
Elaraj, D.M.1
Weinreich, D.M.2
Varghese, S.3
Puhlmann, M.4
Hewitt, S.M.5
Carroll, N.M.6
-
23
-
-
33644829173
-
Interleukin-1 receptor antagonist gene polymorphism in human colorectal cancer
-
Viet HT, Wagsater D, Hugander A, Dimberg J. Interleukin-1 receptor antagonist gene polymorphism in human colorectal cancer. Oncol Rep (2005) 14:915-8. doi:10.3892/or.14.4.915
-
(2005)
Oncol Rep
, vol.14
, pp. 915-918
-
-
Viet, H.T.1
Wagsater, D.2
Hugander, A.3
Dimberg, J.4
-
24
-
-
84899631135
-
Neutrophil infiltration favors colitis-associated tumorigenesis by activating the interleukin-1 (IL-1)/IL-6 axis
-
Wang Y, Wang K, Han GC, Wang RX, Xiao H, Hou CM, et al. Neutrophil infiltration favors colitis-associated tumorigenesis by activating the interleukin-1 (IL-1)/IL-6 axis. Mucosal Immunol (2014) 7:1106-15. doi:10.1038/mi.2013.126
-
(2014)
Mucosal Immunol
, vol.7
, pp. 1106-1115
-
-
Wang, Y.1
Wang, K.2
Han, G.C.3
Wang, R.X.4
Xiao, H.5
Hou, C.M.6
-
25
-
-
70449105185
-
Macrophage-derived IL-1beta stimulates Wnt signaling and growth of colon cancer cells: a crosstalk interrupted by vitamin D3
-
Kaler P, Augenlicht L, Klampfer L. Macrophage-derived IL-1beta stimulates Wnt signaling and growth of colon cancer cells: a crosstalk interrupted by vitamin D3. Oncogene (2009) 28:3892-902. doi:10.1038/onc.2009.247
-
(2009)
Oncogene
, vol.28
, pp. 3892-3902
-
-
Kaler, P.1
Augenlicht, L.2
Klampfer, L.3
-
26
-
-
35448954376
-
Reduced inflammation in the tumor microenvironment delays the accumulation of myeloid-derived suppressor cells and limits tumor progression
-
Bunt SK, Yang L, Sinha P, Clements VK, Leips J, Ostrand-Rosenberg S. Reduced inflammation in the tumor microenvironment delays the accumulation of myeloid-derived suppressor cells and limits tumor progression. Cancer Res (2007) 67:10019-26. doi:10.1158/0008-5472.CAN-07-2354
-
(2007)
Cancer Res
, vol.67
, pp. 10019-10026
-
-
Bunt, S.K.1
Yang, L.2
Sinha, P.3
Clements, V.K.4
Leips, J.5
Ostrand-Rosenberg, S.6
-
27
-
-
54549089856
-
Overexpression of interleukin-1beta induces gastric inflammation and cancer and mobilizes myeloid-derived suppressor cells in mice
-
Tu S, Bhagat G, Cui G, Takaishi S, Kurt-Jones EA, Rickman B, et al. Overexpression of interleukin-1beta induces gastric inflammation and cancer and mobilizes myeloid-derived suppressor cells in mice. Cancer Cell (2008) 14:408-19. doi:10.1016/j.ccr.2008.10.011
-
(2008)
Cancer Cell
, vol.14
, pp. 408-419
-
-
Tu, S.1
Bhagat, G.2
Cui, G.3
Takaishi, S.4
Kurt-Jones, E.A.5
Rickman, B.6
-
28
-
-
29644442445
-
Inflammation induces myeloid-derived suppressor cells that facilitate tumor progression
-
Bunt SK, Sinha P, Clements VK, Leips J, Ostrand-Rosenberg S. Inflammation induces myeloid-derived suppressor cells that facilitate tumor progression. J Immunol (2006) 176:284-90. doi:10.4049/jimmunol.176.1.284
-
(2006)
J Immunol
, vol.176
, pp. 284-290
-
-
Bunt, S.K.1
Sinha, P.2
Clements, V.K.3
Leips, J.4
Ostrand-Rosenberg, S.5
-
29
-
-
65449155181
-
IL-1alpha secreted by colon cancer cells enhances angiogenesis: the relationship between IL-1alpha release and tumor cells' potential for liver metastasis
-
Matsuo Y, Sawai H, Ma J, Xu D, Ochi N, Yasuda A, et al. IL-1alpha secreted by colon cancer cells enhances angiogenesis: the relationship between IL-1alpha release and tumor cells' potential for liver metastasis. J Surg Oncol (2009) 99:361-7. doi:10.1002/jso.21245
-
(2009)
J Surg Oncol
, vol.99
, pp. 361-367
-
-
Matsuo, Y.1
Sawai, H.2
Ma, J.3
Xu, D.4
Ochi, N.5
Yasuda, A.6
-
30
-
-
47249089097
-
IL-1, IL-18, and IL-33 families of cytokines
-
Arend WP, Palmer G, Gabay C. IL-1, IL-18, and IL-33 families of cytokines. Immunol Rev (2008) 223:20-38. doi:10.1111/j.1600-065X.2008.00624.x
-
(2008)
Immunol Rev
, vol.223
, pp. 20-38
-
-
Arend, W.P.1
Palmer, G.2
Gabay, C.3
-
31
-
-
67749117934
-
Signal integration by JNK and p38 MAPK pathways in cancer development
-
Wagner EF, Nebreda AR. Signal integration by JNK and p38 MAPK pathways in cancer development. Nat Rev Cancer (2009) 9:537-49. doi:10.1038/nrc2694
-
(2009)
Nat Rev Cancer
, vol.9
, pp. 537-549
-
-
Wagner, E.F.1
Nebreda, A.R.2
-
32
-
-
77549083560
-
Dangerous liaisons: STAT3 and NF-kappaB collaboration and crosstalk in cancer
-
Grivennikov SI, Karin M. Dangerous liaisons: STAT3 and NF-kappaB collaboration and crosstalk in cancer. Cytokine Growth Factor Rev (2010) 21:11-9. doi:10.1016/j.cytogfr.2009.11.005
-
(2010)
Cytokine Growth Factor Rev
, vol.21
, pp. 11-19
-
-
Grivennikov, S.I.1
Karin, M.2
-
33
-
-
84861986053
-
Wnt/beta-catenin signaling and disease
-
Clevers H, Nusse R. Wnt/beta-catenin signaling and disease. Cell (2012) 149:1192-205. doi:10.1016/j.cell.2012.05.012
-
(2012)
Cell
, vol.149
, pp. 1192-1205
-
-
Clevers, H.1
Nusse, R.2
-
34
-
-
84873810224
-
Impact of COX-2, IL-1beta, TNF-alpha, IL-4 and IL-10 on the process of carcinogenesis in the large bowel
-
Marszalek A, Szylberg L, Wisniewska E, Janiczek M. Impact of COX-2, IL-1beta, TNF-alpha, IL-4 and IL-10 on the process of carcinogenesis in the large bowel. Pol J Pathol (2012) 63:221-7. doi:10.5114/pjp.2012.32768
-
(2012)
Pol J Pathol
, vol.63
, pp. 221-227
-
-
Marszalek, A.1
Szylberg, L.2
Wisniewska, E.3
Janiczek, M.4
-
35
-
-
33645659501
-
Predominant T helper type 2-inflammatory responses promote murine colon cancers
-
Osawa E, Nakajima A, Fujisawa T, Kawamura YI, Toyama-Sorimachi N, Nakagama H, et al. Predominant T helper type 2-inflammatory responses promote murine colon cancers. Int J Cancer (2006) 118:2232-6. doi:10.1002/ijc.21639
-
(2006)
Int J Cancer
, vol.118
, pp. 2232-2236
-
-
Osawa, E.1
Nakajima, A.2
Fujisawa, T.3
Kawamura, Y.I.4
Toyama-Sorimachi, N.5
Nakagama, H.6
-
36
-
-
77953943322
-
Epithelial interleukin-4 receptor expression promotes colon tumor growth
-
Koller FL, Hwang DG, Dozier EA, Fingleton B. Epithelial interleukin-4 receptor expression promotes colon tumor growth. Carcinogenesis (2010) 31:1010-7. doi:10.1093/carcin/bgq044
-
(2010)
Carcinogenesis
, vol.31
, pp. 1010-1017
-
-
Koller, F.L.1
Hwang, D.G.2
Dozier, E.A.3
Fingleton, B.4
-
37
-
-
84885140762
-
Reduced type II interleukin-4 receptor signalling drives initiation, but not progression, of colorectal carcinogenesis: evidence from transgenic mouse models and human case-control epidemiological observations
-
Ingram N, Northwood EL, Perry SL, Marston G, Snowden H, Taylor JC, et al. Reduced type II interleukin-4 receptor signalling drives initiation, but not progression, of colorectal carcinogenesis: evidence from transgenic mouse models and human case-control epidemiological observations. Carcinogenesis (2013) 34:2341-9. doi:10.1093/carcin/bgt222
-
(2013)
Carcinogenesis
, vol.34
, pp. 2341-2349
-
-
Ingram, N.1
Northwood, E.L.2
Perry, S.L.3
Marston, G.4
Snowden, H.5
Taylor, J.C.6
-
38
-
-
79955413653
-
Tumor-reactive CD4+ CD8alphabeta+ CD103+ alphabetaT cells: a prevalent tumor-reactive T-cell subset in metastatic colorectal cancers
-
Sarrabayrouse G, Corvaisier M, Ouisse LH, Bossard C, Le Mevel B, Potiron L, et al. Tumor-reactive CD4+ CD8alphabeta+ CD103+ alphabetaT cells: a prevalent tumor-reactive T-cell subset in metastatic colorectal cancers. Int J Cancer (2011) 128:2923-32. doi:10.1002/ijc.25640
-
(2011)
Int J Cancer
, vol.128
, pp. 2923-2932
-
-
Sarrabayrouse, G.1
Corvaisier, M.2
Ouisse, L.H.3
Bossard, C.4
Le Mevel, B.5
Potiron, L.6
-
39
-
-
84891121499
-
Cancer-initiating cells from colorectal cancer patients escape from T cell-mediated immunosurveillance in vitro through membrane-bound IL-4
-
Volonte A, Di Tomaso T, Spinelli M, Todaro M, Sanvito F, Albarello L, et al. Cancer-initiating cells from colorectal cancer patients escape from T cell-mediated immunosurveillance in vitro through membrane-bound IL-4. J Immunol (2014) 192:523-32. doi:10.4049/jimmunol.1301342
-
(2014)
J Immunol
, vol.192
, pp. 523-532
-
-
Volonte, A.1
Di Tomaso, T.2
Spinelli, M.3
Todaro, M.4
Sanvito, F.5
Albarello, L.6
-
40
-
-
0033010373
-
The IL-4 receptor: signaling mechanisms and biologic functions
-
Nelms K, Keegan AD, Zamorano J, Ryan JJ, Paul WE. The IL-4 receptor: signaling mechanisms and biologic functions. Annu Rev Immunol (1999) 17:701-38. doi:10.1146/annurev.immunol.17.1.701
-
(1999)
Annu Rev Immunol
, vol.17
, pp. 701-738
-
-
Nelms, K.1
Keegan, A.D.2
Zamorano, J.3
Ryan, J.J.4
Paul, W.E.5
-
41
-
-
0034496016
-
IL-4 induces serine phosphorylation of the STAT6 transactivation domain in B lymphocytes
-
Wick KR, Berton MT. IL-4 induces serine phosphorylation of the STAT6 transactivation domain in B lymphocytes. Mol Immunol (2000) 37:641-52. doi:10.1016/S0161-5890(00)00088-2
-
(2000)
Mol Immunol
, vol.37
, pp. 641-652
-
-
Wick, K.R.1
Berton, M.T.2
-
42
-
-
34548165283
-
The IL-4/IL-13/Stat6 signalling pathway promotes luminal mammary epithelial cell development
-
Khaled WT, Read EK, Nicholson SE, Baxter FO, Brennan AJ, Came PJ, et al. The IL-4/IL-13/Stat6 signalling pathway promotes luminal mammary epithelial cell development. Development (2007) 134:2739-50. doi:10.1242/dev.003194
-
(2007)
Development
, vol.134
, pp. 2739-2750
-
-
Khaled, W.T.1
Read, E.K.2
Nicholson, S.E.3
Baxter, F.O.4
Brennan, A.J.5
Came, P.J.6
-
43
-
-
77953176278
-
EZH2 and STAT6 expression profiles are correlated with colorectal cancer stage and prognosis
-
Wang CG, Ye YJ, Yuan J, Liu FF, Zhang H, Wang S. EZH2 and STAT6 expression profiles are correlated with colorectal cancer stage and prognosis. World J Gastroenterol (2010) 16:2421-7. doi:10.3748/wjg.v16.i19.2421
-
(2010)
World J Gastroenterol
, vol.16
, pp. 2421-2427
-
-
Wang, C.G.1
Ye, Y.J.2
Yuan, J.3
Liu, F.F.4
Zhang, H.5
Wang, S.6
-
44
-
-
0026331269
-
Treatment of established renal cancer by tumor cells engineered to secrete interleukin-4
-
Golumbek PT, Lazenby AJ, Levitsky HI, Jaffee LM, Karasuyama H, Baker M, et al. Treatment of established renal cancer by tumor cells engineered to secrete interleukin-4. Science (1991) 254:713-6. doi:10.1126/science.1948050
-
(1991)
Science
, vol.254
, pp. 713-716
-
-
Golumbek, P.T.1
Lazenby, A.J.2
Levitsky, H.I.3
Jaffee, L.M.4
Karasuyama, H.5
Baker, M.6
-
45
-
-
0027203715
-
Treatment of glioma by engineered interleukin 4-secreting cells
-
Yu JS, Wei MX, Chiocca EA, Martuza RL, Tepper RI. Treatment of glioma by engineered interleukin 4-secreting cells. Cancer Res (1993) 53:3125-8
-
(1993)
Cancer Res
, vol.53
, pp. 3125-3128
-
-
Yu, J.S.1
Wei, M.X.2
Chiocca, E.A.3
Martuza, R.L.4
Tepper, R.I.5
-
46
-
-
0026657391
-
An eosinophil-dependent mechanism for the antitumor effect of interleukin-4
-
Tepper RI, Coffman RL, Leder P. An eosinophil-dependent mechanism for the antitumor effect of interleukin-4. Science (1992) 257:548-51. doi:10.1126/science.1636093
-
(1992)
Science
, vol.257
, pp. 548-551
-
-
Tepper, R.I.1
Coffman, R.L.2
Leder, P.3
-
47
-
-
84869758362
-
Interleukin-6-a key regulator of colorectal cancer development
-
Waldner MJ, Foersch S, Neurath MF. Interleukin-6-a key regulator of colorectal cancer development. Int J Biol Sci (2012) 8:1248-53. doi:10.7150/ijbs.4614
-
(2012)
Int J Biol Sci
, vol.8
, pp. 1248-1253
-
-
Waldner, M.J.1
Foersch, S.2
Neurath, M.F.3
-
48
-
-
0031854656
-
Interleukin-6 levels in colorectal cancer tissues
-
Komoda H, Tanaka Y, Honda M, Matsuo Y, Hazama K, Takao T. Interleukin-6 levels in colorectal cancer tissues. World J Surg (1998) 22:895-8. doi:10.1007/s002689900489
-
(1998)
World J Surg
, vol.22
, pp. 895-898
-
-
Komoda, H.1
Tanaka, Y.2
Honda, M.3
Matsuo, Y.4
Hazama, K.5
Takao, T.6
-
49
-
-
0038393312
-
Expression of cyclooxygenase-2 parallels expression of interleukin-1beta, interleukin-6 and NF-kappaB in human colorectal cancer
-
Maihofner C, Charalambous MP, Bhambra U, Lightfoot T, Geisslinger G, Gooderham NJ, et al. Expression of cyclooxygenase-2 parallels expression of interleukin-1beta, interleukin-6 and NF-kappaB in human colorectal cancer. Carcinogenesis (2003) 24:665-71. doi:10.1093/carcin/bgg006
-
(2003)
Carcinogenesis
, vol.24
, pp. 665-671
-
-
Maihofner, C.1
Charalambous, M.P.2
Bhambra, U.3
Lightfoot, T.4
Geisslinger, G.5
Gooderham, N.J.6
-
50
-
-
0042209597
-
Serum interleukin-6 levels reflect the disease status of colorectal cancer
-
Chung YC, Chang YF. Serum interleukin-6 levels reflect the disease status of colorectal cancer. J Surg Oncol (2003) 83:222-6. doi:10.1002/jso.10269
-
(2003)
J Surg Oncol
, vol.83
, pp. 222-226
-
-
Chung, Y.C.1
Chang, Y.F.2
-
51
-
-
0034106055
-
Interleukin-6 blood level is associated with circulating carcinoembryonic antigen and prognosis in patients with colorectal cancer
-
Belluco C, Nitti D, Frantz M, Toppan P, Basso D, Plebani M, et al. Interleukin-6 blood level is associated with circulating carcinoembryonic antigen and prognosis in patients with colorectal cancer. Ann Surg Oncol (2000) 7:133-8. doi:10.1007/s10434-000-0133-7
-
(2000)
Ann Surg Oncol
, vol.7
, pp. 133-138
-
-
Belluco, C.1
Nitti, D.2
Frantz, M.3
Toppan, P.4
Basso, D.5
Plebani, M.6
-
52
-
-
0032807379
-
Elevated serum thrombopoietin and interleukin-6 concentrations in thrombocytosis associated with inflammatory bowel disease
-
Heits F, Stahl M, Ludwig D, Stange EF, Jelkmann W. Elevated serum thrombopoietin and interleukin-6 concentrations in thrombocytosis associated with inflammatory bowel disease. J Interferon Cytokine Res (1999) 19:757-60. doi:10.1089/107999099313604
-
(1999)
J Interferon Cytokine Res
, vol.19
, pp. 757-760
-
-
Heits, F.1
Stahl, M.2
Ludwig, D.3
Stange, E.F.4
Jelkmann, W.5
-
53
-
-
18344410191
-
Blockade of interleukin 6 trans signaling suppresses T-cell resistance against apoptosis in chronic intestinal inflammation: evidence in crohn disease and experimental colitis in vivo
-
Atreya R, Mudter J, Finotto S, Mullberg J, Jostock T, Wirtz S, et al. Blockade of interleukin 6 trans signaling suppresses T-cell resistance against apoptosis in chronic intestinal inflammation: evidence in crohn disease and experimental colitis in vivo. Nat Med (2000) 6:583-8. doi:10.1038/75068
-
(2000)
Nat Med
, vol.6
, pp. 583-588
-
-
Atreya, R.1
Mudter, J.2
Finotto, S.3
Mullberg, J.4
Jostock, T.5
Wirtz, S.6
-
54
-
-
5644252874
-
TGF-beta suppresses tumor progression in colon cancer by inhibition of IL-6 trans-signaling
-
Becker C, Fantini MC, Schramm C, Lehr HA, Wirtz S, Nikolaev A, et al. TGF-beta suppresses tumor progression in colon cancer by inhibition of IL-6 trans-signaling. Immunity (2004) 21:491-501. doi:10.1016/j.immuni.2004.07.020
-
(2004)
Immunity
, vol.21
, pp. 491-501
-
-
Becker, C.1
Fantini, M.C.2
Schramm, C.3
Lehr, H.A.4
Wirtz, S.5
Nikolaev, A.6
-
55
-
-
58649108302
-
IL-6 and Stat3 are required for survival of intestinal epithelial cells and development of colitis-associated cancer
-
Grivennikov S, Karin E, Terzic J, Mucida D, Yu GY, Vallabhapurapu S, et al. IL-6 and Stat3 are required for survival of intestinal epithelial cells and development of colitis-associated cancer. Cancer Cell (2009) 15:103-13. doi:10.1016/j.ccr.2009.01.001
-
(2009)
Cancer Cell
, vol.15
, pp. 103-113
-
-
Grivennikov, S.1
Karin, E.2
Terzic, J.3
Mucida, D.4
Yu, G.Y.5
Vallabhapurapu, S.6
-
56
-
-
84892917277
-
Interleukin-6 released by colon cancer-associated fibroblasts is critical for tumour angiogenesis: anti-interleukin-6 receptor antibody suppressed angiogenesis and inhibited tumour-stroma interaction
-
Nagasaki T, Hara M, Nakanishi H, Takahashi H, Sato M, Takeyama H. Interleukin-6 released by colon cancer-associated fibroblasts is critical for tumour angiogenesis: anti-interleukin-6 receptor antibody suppressed angiogenesis and inhibited tumour-stroma interaction. Br J Cancer (2014) 110:469-78. doi:10.1038/bjc.2013.748
-
(2014)
Br J Cancer
, vol.110
, pp. 469-478
-
-
Nagasaki, T.1
Hara, M.2
Nakanishi, H.3
Takahashi, H.4
Sato, M.5
Takeyama, H.6
-
57
-
-
84900841536
-
Tumor-associated macrophage-derived IL-6 and IL-8 enhance invasive activity of LoVo cells induced by PRL-3 in a KCNN4 channel-dependent manner
-
Xu H, Lai W, Zhang Y, Liu L, Luo X, Zeng Y, et al. Tumor-associated macrophage-derived IL-6 and IL-8 enhance invasive activity of LoVo cells induced by PRL-3 in a KCNN4 channel-dependent manner. BMC Cancer (2014) 14:330. doi:10.1186/1471-2407-14-330
-
(2014)
BMC Cancer
, vol.14
, pp. 330
-
-
Xu, H.1
Lai, W.2
Zhang, Y.3
Liu, L.4
Luo, X.5
Zeng, Y.6
-
58
-
-
84924069554
-
Interleukin 6 alters localization of hMSH3, leading to DNA mismatch repair defects in colorectal cancer cells
-
Tseng-Rogenski SS, Hamaya Y, Choi DY, Carethers JM. Interleukin 6 alters localization of hMSH3, leading to DNA mismatch repair defects in colorectal cancer cells. Gastroenterology (2015) 148:579-89. doi:10.1053/j.gastro.2014.11.027
-
(2015)
Gastroenterology
, vol.148
, pp. 579-589
-
-
Tseng-Rogenski, S.S.1
Hamaya, Y.2
Choi, D.Y.3
Carethers, J.M.4
-
59
-
-
84887530424
-
Myeloid-derived suppressor cells attenuate TH1 development through IL-6 production to promote tumor progression
-
Tsukamoto H, Nishikata R, Senju S, Nishimura Y. Myeloid-derived suppressor cells attenuate TH1 development through IL-6 production to promote tumor progression. Cancer Immunol Res (2013) 1:64-76. doi:10.1158/2326-6066.CIR-13-0030
-
(2013)
Cancer Immunol Res
, vol.1
, pp. 64-76
-
-
Tsukamoto, H.1
Nishikata, R.2
Senju, S.3
Nishimura, Y.4
-
60
-
-
84869797922
-
IL-6 trans-signaling via the soluble IL-6 receptor: importance for the pro-inflammatory activities of IL-6
-
Rose-John S. IL-6 trans-signaling via the soluble IL-6 receptor: importance for the pro-inflammatory activities of IL-6. Int J Biol Sci (2012) 8:1237-47. doi:10.7150/ijbs.4989
-
(2012)
Int J Biol Sci
, vol.8
, pp. 1237-1247
-
-
Rose-John, S.1
-
61
-
-
22044437986
-
Persistent STAT3 activation in colon cancer is associated with enhanced cell proliferation and tumor growth
-
Corvinus FM, Orth C, Moriggl R, Tsareva SA, Wagner S, Pfitzner EB, et al. Persistent STAT3 activation in colon cancer is associated with enhanced cell proliferation and tumor growth. Neoplasia (2005) 7:545-55. doi:10.1593/neo.04571
-
(2005)
Neoplasia
, vol.7
, pp. 545-555
-
-
Corvinus, F.M.1
Orth, C.2
Moriggl, R.3
Tsareva, S.A.4
Wagner, S.5
Pfitzner, E.B.6
-
62
-
-
33847406439
-
Activation of STAT3 is a marker of poor prognosis in human colorectal cancer
-
Kusaba T, Nakayama T, Yamazumi K, Yakata Y, Yoshizaki A, Inoue K, et al. Activation of STAT3 is a marker of poor prognosis in human colorectal cancer. Oncol Rep (2006) 15:1445-51. doi:10.3892/or.15.6.1445
-
(2006)
Oncol Rep
, vol.15
, pp. 1445-1451
-
-
Kusaba, T.1
Nakayama, T.2
Yamazumi, K.3
Yakata, Y.4
Yoshizaki, A.5
Inoue, K.6
-
63
-
-
79952715805
-
STAT3 expression, molecular features, inflammation patterns, and prognosis in a database of 724 colorectal cancers
-
Morikawa T, Baba Y, Yamauchi M, Kuchiba A, Nosho K, Shima K, et al. STAT3 expression, molecular features, inflammation patterns, and prognosis in a database of 724 colorectal cancers. Clin Cancer Res (2011) 17:1452-62. doi:10.1158/1078-0432.CCR-10-2694
-
(2011)
Clin Cancer Res
, vol.17
, pp. 1452-1462
-
-
Morikawa, T.1
Baba, Y.2
Yamauchi, M.3
Kuchiba, A.4
Nosho, K.5
Shima, K.6
-
64
-
-
84871320421
-
Mice that express human interleukin-8 have increased mobilization of immature myeloid cells, which exacerbates inflammation and accelerates colon carcinogenesis
-
Asfaha S, Dubeykovskiy AN, Tomita H, Yang X, Stokes S, Shibata W, et al. Mice that express human interleukin-8 have increased mobilization of immature myeloid cells, which exacerbates inflammation and accelerates colon carcinogenesis. Gastroenterology (2013) 144:155-66. doi:10.1053/j.gastro.2012.09.057
-
(2013)
Gastroenterology
, vol.144
, pp. 155-166
-
-
Asfaha, S.1
Dubeykovskiy, A.N.2
Tomita, H.3
Yang, X.4
Stokes, S.5
Shibata, W.6
-
65
-
-
53049095891
-
Polymorphisms in VEGF and IL-8 predict tumor recurrence in stage III colon cancer
-
Lurje G, Zhang W, Schultheis AM, Yang D, Groshen S, Hendifar AE, et al. Polymorphisms in VEGF and IL-8 predict tumor recurrence in stage III colon cancer. Ann Oncol (2008) 19:1734-41. doi:10.1093/annonc/mdn368
-
(2008)
Ann Oncol
, vol.19
, pp. 1734-1741
-
-
Lurje, G.1
Zhang, W.2
Schultheis, A.M.3
Yang, D.4
Groshen, S.5
Hendifar, A.E.6
-
66
-
-
79959994448
-
SNAIL regulates interleukin-8 expression, stem cell-like activity, and tumorigenicity of human colorectal carcinoma cells
-
Hwang WL, Yang MH, Tsai ML, Lan HY, Su SH, Chang SC, et al. SNAIL regulates interleukin-8 expression, stem cell-like activity, and tumorigenicity of human colorectal carcinoma cells. Gastroenterology (2011) 141:e271-5. doi:10.1053/j.gastro.2011.04.008
-
(2011)
Gastroenterology
, vol.141
, pp. e271-e275
-
-
Hwang, W.L.1
Yang, M.H.2
Tsai, M.L.3
Lan, H.Y.4
Su, S.H.5
Chang, S.C.6
-
67
-
-
61349100687
-
Myeloid-derived suppressor cells as regulators of the immune system
-
Gabrilovich DI, Nagaraj S. Myeloid-derived suppressor cells as regulators of the immune system. Nat Rev Immunol (2009) 9:162-74. doi:10.1038/nri2506
-
(2009)
Nat Rev Immunol
, vol.9
, pp. 162-174
-
-
Gabrilovich, D.I.1
Nagaraj, S.2
-
68
-
-
0034792393
-
Expression of interleukin 8 and its receptors in human colon carcinoma cells with different metastatic potentials
-
Li A, Varney ML, Singh RK. Expression of interleukin 8 and its receptors in human colon carcinoma cells with different metastatic potentials. Clin Cancer Res (2001) 7:3298-304
-
(2001)
Clin Cancer Res
, vol.7
, pp. 3298-3304
-
-
Li, A.1
Varney, M.L.2
Singh, R.K.3
-
69
-
-
79952471898
-
Interleukin-8 is associated with proliferation, migration, angiogenesis and chemosensitivity in vitro and in vivo in colon cancer cell line models
-
Ning Y, Manegold PC, Hong YK, Zhang W, Pohl A, Lurje G, et al. Interleukin-8 is associated with proliferation, migration, angiogenesis and chemosensitivity in vitro and in vivo in colon cancer cell line models. Int J Cancer (2011) 128:2038-49. doi:10.1002/ijc.25562
-
(2011)
Int J Cancer
, vol.128
, pp. 2038-2049
-
-
Ning, Y.1
Manegold, P.C.2
Hong, Y.K.3
Zhang, W.4
Pohl, A.5
Lurje, G.6
-
70
-
-
58149232586
-
The interleukin-8 pathway in cancer
-
Waugh DJ, Wilson C. The interleukin-8 pathway in cancer. Clin Cancer Res (2008) 14:6735-41. doi:10.1158/1078-0432.CCR-07-4843
-
(2008)
Clin Cancer Res
, vol.14
, pp. 6735-6741
-
-
Waugh, D.J.1
Wilson, C.2
-
71
-
-
84879332695
-
The role of interleukin-9 in lymphoma
-
Lv X, Wang X. The role of interleukin-9 in lymphoma. Leuk Lymphoma (2013) 54:1367-72. doi:10.3109/10428194.2012.745072
-
(2013)
Leuk Lymphoma
, vol.54
, pp. 1367-1372
-
-
Lv, X.1
Wang, X.2
-
72
-
-
84864648969
-
Robust tumor immunity to melanoma mediated by interleukin-9-producing T cells
-
Purwar R, Schlapbach C, Xiao S, Kang HS, Elyaman W, Jiang X, et al. Robust tumor immunity to melanoma mediated by interleukin-9-producing T cells. Nat Med (2012) 18:1248-53. doi:10.1038/nm.2856
-
(2012)
Nat Med
, vol.18
, pp. 1248-1253
-
-
Purwar, R.1
Schlapbach, C.2
Xiao, S.3
Kang, H.S.4
Elyaman, W.5
Jiang, X.6
-
73
-
-
84934435293
-
IL-9 inhibits HTB-72 melanoma cell growth through upregulation of p21 and TRAIL
-
Fang Y, Chen X, Bai Q, Qin C, Mohamud AO, Zhu Z, et al. IL-9 inhibits HTB-72 melanoma cell growth through upregulation of p21 and TRAIL. J Surg Oncol (2015) 111:969-74. doi:10.1002/jso.23930
-
(2015)
J Surg Oncol
, vol.111
, pp. 969-974
-
-
Fang, Y.1
Chen, X.2
Bai, Q.3
Qin, C.4
Mohamud, A.O.5
Zhu, Z.6
-
74
-
-
84937680554
-
Association between low expression levels of interleukin-9 and colon cancer progression
-
Huang Y, Cao Y, Zhang S, Gao F. Association between low expression levels of interleukin-9 and colon cancer progression. Exp Ther Med (2015) 10:942-6. doi:10.3892/etm.2015.2588
-
(2015)
Exp Ther Med
, vol.10
, pp. 942-946
-
-
Huang, Y.1
Cao, Y.2
Zhang, S.3
Gao, F.4
-
75
-
-
84917709115
-
Inhibition of adaptive immunity by IL9 can be disrupted to achieve rapid T-cell sensitization and rejection of progressive tumor challenges
-
Hoelzinger DB, Dominguez AL, Cohen PA, Gendler SJ. Inhibition of adaptive immunity by IL9 can be disrupted to achieve rapid T-cell sensitization and rejection of progressive tumor challenges. Cancer Res (2014) 74:6845-55. doi:10.1158/0008-5472.CAN-14-0836
-
(2014)
Cancer Res
, vol.74
, pp. 6845-6855
-
-
Hoelzinger, D.B.1
Dominguez, A.L.2
Cohen, P.A.3
Gendler, S.J.4
-
76
-
-
32044442107
-
Induction of enhanced immunity to intestinal nematodes using IL-9-producing dendritic cells
-
Leech MD, Grencis RK. Induction of enhanced immunity to intestinal nematodes using IL-9-producing dendritic cells. J Immunol (2006) 176:2505-11. doi:10.4049/jimmunol.176.4.2505
-
(2006)
J Immunol
, vol.176
, pp. 2505-2511
-
-
Leech, M.D.1
Grencis, R.K.2
-
77
-
-
56349154943
-
Transforming growth factor-beta 'reprograms' the differentiation of T helper 2 cells and promotes an interleukin 9-producing subset
-
Veldhoen M, Uyttenhove C, van Snick J, Helmby H, Westendorf A, Buer J, et al. Transforming growth factor-beta 'reprograms' the differentiation of T helper 2 cells and promotes an interleukin 9-producing subset. Nat Immunol (2008) 9:1341-6. doi:10.1038/ni.1659
-
(2008)
Nat Immunol
, vol.9
, pp. 1341-1346
-
-
Veldhoen, M.1
Uyttenhove, C.2
van Snick, J.3
Helmby, H.4
Westendorf, A.5
Buer, J.6
-
78
-
-
84874056674
-
IL-9-producing invariant NKT cells protect against DSS-induced colitis in an IL-4-dependent manner
-
Kim HS, Chung DH. IL-9-producing invariant NKT cells protect against DSS-induced colitis in an IL-4-dependent manner. Mucosal Immunol (2013) 6:347-57. doi:10.1038/mi.2012.77
-
(2013)
Mucosal Immunol
, vol.6
, pp. 347-357
-
-
Kim, H.S.1
Chung, D.H.2
-
79
-
-
84887108621
-
Proteome profiling of cancer-associated fibroblasts identifies novel proinflammatory signatures and prognostic markers for colorectal cancer
-
Torres S, Bartolome RA, Mendes M, Barderas R, Fernandez-Acenero MJ, Pelaez-Garcia A, et al. Proteome profiling of cancer-associated fibroblasts identifies novel proinflammatory signatures and prognostic markers for colorectal cancer. Clin Cancer Res (2013) 19:6006-19. doi:10.1158/1078-0432.CCR-13-1130
-
(2013)
Clin Cancer Res
, vol.19
, pp. 6006-6019
-
-
Torres, S.1
Bartolome, R.A.2
Mendes, M.3
Barderas, R.4
Fernandez-Acenero, M.J.5
Pelaez-Garcia, A.6
-
80
-
-
84928584525
-
IL-9 and its receptor are predominantly involved in the pathogenesis of UC
-
Nalleweg N, Chiriac MT, Podstawa E, Lehmann C, Rau TT, Atreya R, et al. IL-9 and its receptor are predominantly involved in the pathogenesis of UC. Gut (2015) 64:743-55. doi:10.1136/gutjnl-2013-305947
-
(2015)
Gut
, vol.64
, pp. 743-755
-
-
Nalleweg, N.1
Chiriac, M.T.2
Podstawa, E.3
Lehmann, C.4
Rau, T.T.5
Atreya, R.6
-
81
-
-
78751591699
-
Expression of phosphorylated Stat5 predicts expression of cyclin D1 and correlates with poor prognosis of colonic adenocarcinoma
-
Mao Y, Li Z, Lou C, Zhang Y. Expression of phosphorylated Stat5 predicts expression of cyclin D1 and correlates with poor prognosis of colonic adenocarcinoma. Int J Colorectal Dis (2011) 26:29-35. doi:10.1007/s00384-010-1090-7
-
(2011)
Int J Colorectal Dis
, vol.26
, pp. 29-35
-
-
Mao, Y.1
Li, Z.2
Lou, C.3
Zhang, Y.4
-
82
-
-
0031872995
-
Advanced colorectal cancer is associated with impaired interleukin 12 and enhanced interleukin 10 production
-
O'Hara RJ, Greenman J, MacDonald AW, Gaskell KM, Topping KP, Duthie GS, et al. Advanced colorectal cancer is associated with impaired interleukin 12 and enhanced interleukin 10 production. Clin Cancer Res (1998) 4:1943-8
-
(1998)
Clin Cancer Res
, vol.4
, pp. 1943-1948
-
-
O'Hara, R.J.1
Greenman, J.2
MacDonald, A.W.3
Gaskell, K.M.4
Topping, K.P.5
Duthie, G.S.6
-
83
-
-
77951971709
-
Advanced colorectal cancer is associated with enhanced IL-23 and IL-10 serum levels
-
Stanilov N, Miteva L, Deliysky T, Jovchev J, Stanilova S. Advanced colorectal cancer is associated with enhanced IL-23 and IL-10 serum levels. Lab Med (2010) 41:159-63. doi:10.1309/Lm7t43aqziupiowz
-
(2010)
Lab Med
, vol.41
, pp. 159-163
-
-
Stanilov, N.1
Miteva, L.2
Deliysky, T.3
Jovchev, J.4
Stanilova, S.5
-
84
-
-
84919890714
-
Significance of-1082A/G polymorphism of IL10 gene for progression of colorectal cancer and IL-10 expression
-
Miteva LD, Stanilov NS, Deliysky TS, Stanilova SA. Significance of-1082A/G polymorphism of IL10 gene for progression of colorectal cancer and IL-10 expression. Tumour Biol (2014) 35:12655-64. doi:10.1007/s13277-014-2589-2
-
(2014)
Tumour Biol
, vol.35
, pp. 12655-12664
-
-
Miteva, L.D.1
Stanilov, N.S.2
Deliysky, T.S.3
Stanilova, S.A.4
-
85
-
-
20144375359
-
CD4+CD25+ regulatory lymphocytes induce regression of intestinal tumors in ApcMin/+ mice
-
Erdman SE, Sohn JJ, Rao VP, Nambiar PR, Ge Z, Fox JG, et al. CD4+CD25+ regulatory lymphocytes induce regression of intestinal tumors in ApcMin/+ mice. Cancer Res (2005) 65:3998-4004. doi:10.1158/0008-5472.CAN-04-3104
-
(2005)
Cancer Res
, vol.65
, pp. 3998-4004
-
-
Erdman, S.E.1
Sohn, J.J.2
Rao, V.P.3
Nambiar, P.R.4
Ge, Z.5
Fox, J.G.6
-
86
-
-
67650462939
-
T-regulatory cells shift from a protective anti-inflammatory to a cancer-promoting proinflammatory phenotype in polyposis
-
Gounaris E, Blatner NR, Dennis K, Magnusson F, Gurish MF, Strom TB, et al. T-regulatory cells shift from a protective anti-inflammatory to a cancer-promoting proinflammatory phenotype in polyposis. Cancer Res (2009) 69:5490-7. doi:10.1158/0008-5472.CAN-09-0304
-
(2009)
Cancer Res
, vol.69
, pp. 5490-5497
-
-
Gounaris, E.1
Blatner, N.R.2
Dennis, K.3
Magnusson, F.4
Gurish, M.F.5
Strom, T.B.6
-
87
-
-
84907495388
-
Oral interleukin-10 alleviates polyposis via neutralization of pathogenic T-regulatory cells
-
Chung AY, Li Q, Blair SJ, De Jesus M, Dennis KL, LeVea C, et al. Oral interleukin-10 alleviates polyposis via neutralization of pathogenic T-regulatory cells. Cancer Res (2014) 74:5377-85. doi:10.1158/0008-5472.CAN-14-0918
-
(2014)
Cancer Res
, vol.74
, pp. 5377-5385
-
-
Chung, A.Y.1
Li, Q.2
Blair, S.J.3
De Jesus, M.4
Dennis, K.L.5
LeVea, C.6
-
88
-
-
84885064968
-
Adenomatous polyps are driven by microbe-instigated focal inflammation and are controlled by IL-10-producing T cells
-
Dennis KL, Wang Y, Blatner NR, Wang S, Saadalla A, Trudeau E, et al. Adenomatous polyps are driven by microbe-instigated focal inflammation and are controlled by IL-10-producing T cells. Cancer Res (2013) 73:5905-13. doi:10.1158/0008-5472.CAN-13-1511
-
(2013)
Cancer Res
, vol.73
, pp. 5905-5913
-
-
Dennis, K.L.1
Wang, Y.2
Blatner, N.R.3
Wang, S.4
Saadalla, A.5
Trudeau, E.6
-
89
-
-
0029813545
-
Enterocolitis and colon cancer in interleukin-10-deficient mice are associated with aberrant cytokine production and CD4(+) TH1-like responses
-
Berg DJ, Davidson N, Kuhn R, Muller W, Menon S, Holland G, et al. Enterocolitis and colon cancer in interleukin-10-deficient mice are associated with aberrant cytokine production and CD4(+) TH1-like responses. J Clin Invest (1996) 98:1010-20. doi:10.1172/JCI118861
-
(1996)
J Clin Invest
, vol.98
, pp. 1010-1020
-
-
Berg, D.J.1
Davidson, N.2
Kuhn, R.3
Muller, W.4
Menon, S.5
Holland, G.6
-
90
-
-
0030704726
-
A CD4+ T-cell subset inhibits antigen-specific T-cell responses and prevents colitis
-
Groux H, O'Garra A, Bigler M, Rouleau M, Antonenko S, de Vries JE, et al. A CD4+ T-cell subset inhibits antigen-specific T-cell responses and prevents colitis. Nature (1997) 389:737-42. doi:10.1038/39614
-
(1997)
Nature
, vol.389
, pp. 737-742
-
-
Groux, H.1
O'Garra, A.2
Bigler, M.3
Rouleau, M.4
Antonenko, S.5
de Vries, J.E.6
-
91
-
-
0036893171
-
Prevention of colitis by interleukin 10-transduced T lymphocytes in the SCID mice transfer model
-
Van Montfrans C, Rodriguez Pena MS, Pronk I, Ten Kate FJ, Te Velde AA, Van Deventer SJ. Prevention of colitis by interleukin 10-transduced T lymphocytes in the SCID mice transfer model. Gastroenterology (2002) 123:1865-76. doi:10.1053/gast.2002.37067
-
(2002)
Gastroenterology
, vol.123
, pp. 1865-1876
-
-
Van Montfrans, C.1
Rodriguez Pena, M.S.2
Pronk, I.3
Ten Kate, F.J.4
Te Velde, A.A.5
Van Deventer, S.J.6
-
92
-
-
84929192010
-
IL-10-producing intestinal macrophages prevent excessive antibacterial innate immunity by limiting IL-23 synthesis
-
Krause P, Morris V, Greenbaum JA, Park Y, Bjoerheden U, Mikulski Z, et al. IL-10-producing intestinal macrophages prevent excessive antibacterial innate immunity by limiting IL-23 synthesis. Nat Commun (2015) 6:7055. doi:10.1038/ncomms8055
-
(2015)
Nat Commun
, vol.6
, pp. 7055
-
-
Krause, P.1
Morris, V.2
Greenbaum, J.A.3
Park, Y.4
Bjoerheden, U.5
Mikulski, Z.6
-
93
-
-
0033966397
-
Expression of IL-10 receptors on epithelial cells from the murine small and large intestine
-
Denning TL, Campbell NA, Song F, Garofalo RP, Klimpel GR, Reyes VE, et al. Expression of IL-10 receptors on epithelial cells from the murine small and large intestine. Int Immunol (2000) 12:133-9. doi:10.1093/intimm/12.2.133
-
(2000)
Int Immunol
, vol.12
, pp. 133-139
-
-
Denning, T.L.1
Campbell, N.A.2
Song, F.3
Garofalo, R.P.4
Klimpel, G.R.5
Reyes, V.E.6
-
94
-
-
84893351700
-
Interleukin 10 receptor signaling: master regulator of intestinal mucosal homeostasis in mice and humans
-
Shouval DS, Ouahed J, Biswas A, Goettel JA, Horwitz BH, Klein C, et al. Interleukin 10 receptor signaling: master regulator of intestinal mucosal homeostasis in mice and humans. Adv Immunol (2014) 122:177-210. doi:10.1016/B978-0-12-800267-4.00005-5
-
(2014)
Adv Immunol
, vol.122
, pp. 177-210
-
-
Shouval, D.S.1
Ouahed, J.2
Biswas, A.3
Goettel, J.A.4
Horwitz, B.H.5
Klein, C.6
-
95
-
-
0030573991
-
IL-10 induces DNA binding activity of three STAT proteins (Stat1, Stat3, and Stat5) and their distinct combinatorial assembly in the promoters of selected genes
-
Wehinger J, Gouilleux F, Groner B, Finke J, Mertelsmann R, Weber-Nordt RM. IL-10 induces DNA binding activity of three STAT proteins (Stat1, Stat3, and Stat5) and their distinct combinatorial assembly in the promoters of selected genes. FEBS Lett (1996) 394:365-70. doi:10.1016/0014-5793(96)00990-8
-
(1996)
FEBS Lett
, vol.394
, pp. 365-370
-
-
Wehinger, J.1
Gouilleux, F.2
Groner, B.3
Finke, J.4
Mertelsmann, R.5
Weber-Nordt, R.M.6
-
96
-
-
37249088620
-
Expression of interleukin (IL)-11 and IL-11 receptor in human colorectal adenocarcinoma: IL-11 up-regulation of the invasive and proliferative activity of human colorectal carcinoma cells
-
Yoshizaki A, Nakayama T, Yamazumi K, Yakata Y, Taba M, Sekine I. Expression of interleukin (IL)-11 and IL-11 receptor in human colorectal adenocarcinoma: IL-11 up-regulation of the invasive and proliferative activity of human colorectal carcinoma cells. Int J Oncol (2006) 29:869-76. doi:10.3892/ijo.29.4.869
-
(2006)
Int J Oncol
, vol.29
, pp. 869-876
-
-
Yoshizaki, A.1
Nakayama, T.2
Yamazumi, K.3
Yakata, Y.4
Taba, M.5
Sekine, I.6
-
97
-
-
84881534116
-
Interleukin-11 is the dominant IL-6 family cytokine during gastrointestinal tumorigenesis and can be targeted therapeutically
-
Putoczki TL, Thiem S, Loving A, Busuttil RA, Wilson NJ, Ziegler PK, et al. Interleukin-11 is the dominant IL-6 family cytokine during gastrointestinal tumorigenesis and can be targeted therapeutically. Cancer Cell (2013) 24:257-71. doi:10.1016/j.ccr.2013.06.017
-
(2013)
Cancer Cell
, vol.24
, pp. 257-271
-
-
Putoczki, T.L.1
Thiem, S.2
Loving, A.3
Busuttil, R.A.4
Wilson, N.J.5
Ziegler, P.K.6
-
98
-
-
0028967287
-
Mouse interleukin-12 (IL-12) p40 homodimer: a potent IL-12 antagonist
-
Gillessen S, Carvajal D, Ling P, Podlaski FJ, Stremlo DL, Familletti PC, et al. Mouse interleukin-12 (IL-12) p40 homodimer: a potent IL-12 antagonist. Eur J Immunol (1995) 25:200-6. doi:10.1002/eji.1830250133
-
(1995)
Eur J Immunol
, vol.25
, pp. 200-206
-
-
Gillessen, S.1
Carvajal, D.2
Ling, P.3
Podlaski, F.J.4
Stremlo, D.L.5
Familletti, P.C.6
-
99
-
-
36549030784
-
The inhibitory cytokine IL-35 contributes to regulatory T-cell function
-
Collison LW, Workman CJ, Kuo TT, Boyd K, Wang Y, Vignali KM, et al. The inhibitory cytokine IL-35 contributes to regulatory T-cell function. Nature (2007) 450:566-9. doi:10.1038/nature06306
-
(2007)
Nature
, vol.450
, pp. 566-569
-
-
Collison, L.W.1
Workman, C.J.2
Kuo, T.T.3
Boyd, K.4
Wang, Y.5
Vignali, K.M.6
-
100
-
-
36248970671
-
IL-35 is a novel cytokine with therapeutic effects against collagen-induced arthritis through the expansion of regulatory T cells and suppression of Th17 cells
-
Niedbala W, Wei XQ, Cai B, Hueber AJ, Leung BP, McInnes IB, et al. IL-35 is a novel cytokine with therapeutic effects against collagen-induced arthritis through the expansion of regulatory T cells and suppression of Th17 cells. Eur J Immunol (2007) 37:3021-9. doi:10.1002/eji.200737810
-
(2007)
Eur J Immunol
, vol.37
, pp. 3021-3029
-
-
Niedbala, W.1
Wei, X.Q.2
Cai, B.3
Hueber, A.J.4
Leung, B.P.5
McInnes, I.B.6
-
101
-
-
0033638507
-
Novel p19 protein engages IL-12p40 to form a cytokine, IL-23, with biological activities similar as well as distinct from IL-12
-
Oppmann B, Lesley R, Blom B, Timans JC, Xu Y, Hunte B, et al. Novel p19 protein engages IL-12p40 to form a cytokine, IL-23, with biological activities similar as well as distinct from IL-12. Immunity (2000) 13:715-25. doi:10.1016/S1074-7613(00)00070-4
-
(2000)
Immunity
, vol.13
, pp. 715-725
-
-
Oppmann, B.1
Lesley, R.2
Blom, B.3
Timans, J.C.4
Xu, Y.5
Hunte, B.6
-
102
-
-
84922480473
-
The prognostic value of preoperative serum levels of IL-12p40 and IL-23 for survival of patients with colorectal cancer
-
Stanilov N, Miteva L, Jovchev J, Cirovski G, Stanilova S. The prognostic value of preoperative serum levels of IL-12p40 and IL-23 for survival of patients with colorectal cancer. APMIS (2014) 122:1223-9. doi:10.1111/apm.12288
-
(2014)
APMIS
, vol.122
, pp. 1223-1229
-
-
Stanilov, N.1
Miteva, L.2
Jovchev, J.3
Cirovski, G.4
Stanilova, S.5
-
103
-
-
84876872556
-
Dendritic cell inhibition correlates with survival of colorectal cancer patients on bevacizumab treatment
-
Michielsen AJ, Ryan EJ, O'Sullivan JN. Dendritic cell inhibition correlates with survival of colorectal cancer patients on bevacizumab treatment. Oncoimmunology (2012) 1:1445-7. doi:10.4161/onci.21318
-
(2012)
Oncoimmunology
, vol.1
, pp. 1445-1447
-
-
Michielsen, A.J.1
Ryan, E.J.2
O'Sullivan, J.N.3
-
104
-
-
0027239503
-
Antitumor and antimetastatic activity of interleukin 12 against murine tumors
-
Brunda MJ, Luistro L, Warrier RR, Wright RB, Hubbard BR, Murphy M, et al. Antitumor and antimetastatic activity of interleukin 12 against murine tumors. J Exp Med (1993) 178:1223-30. doi:10.1084/jem.178.4.1223
-
(1993)
J Exp Med
, vol.178
, pp. 1223-1230
-
-
Brunda, M.J.1
Luistro, L.2
Warrier, R.R.3
Wright, R.B.4
Hubbard, B.R.5
Murphy, M.6
-
105
-
-
0027963161
-
Recombinant IL-12 administration induces tumor regression in association with IFN-gamma production
-
Nastala CL, Edington HD, McKinney TG, Tahara H, Nalesnik MA, Brunda MJ, et al. Recombinant IL-12 administration induces tumor regression in association with IFN-gamma production. J Immunol (1994) 153:1697-706
-
(1994)
J Immunol
, vol.153
, pp. 1697-1706
-
-
Nastala, C.L.1
Edington, H.D.2
McKinney, T.G.3
Tahara, H.4
Nalesnik, M.A.5
Brunda, M.J.6
-
106
-
-
0034284460
-
The anti-tumor activity of IL-12: mechanisms of innate immunity that are model and dose dependent
-
Smyth MJ, Taniguchi M, Street SE. The anti-tumor activity of IL-12: mechanisms of innate immunity that are model and dose dependent. J Immunol (2000) 165:2665-70. doi:10.4049/jimmunol.165.5.2665
-
(2000)
J Immunol
, vol.165
, pp. 2665-2670
-
-
Smyth, M.J.1
Taniguchi, M.2
Street, S.E.3
-
107
-
-
77958153282
-
IL-12 initiates tumor rejection via lymphoid tissue-inducer cells bearing the natural cytotoxicity receptor NKp46
-
Eisenring M, vom Berg J, Kristiansen G, Saller E, Becher B. IL-12 initiates tumor rejection via lymphoid tissue-inducer cells bearing the natural cytotoxicity receptor NKp46. Nat Immunol (2010) 11:1030-8. doi:10.1038/ni.1947
-
(2010)
Nat Immunol
, vol.11
, pp. 1030-1038
-
-
Eisenring, M.1
vom Berg, J.2
Kristiansen, G.3
Saller, E.4
Becher, B.5
-
108
-
-
13544270758
-
Production of interleukin (IL)-10 and IL-12 by murine colonic dendritic cells in response to microbial stimuli
-
Rigby RJ, Knight SC, Kamm MA, Stagg AJ. Production of interleukin (IL)-10 and IL-12 by murine colonic dendritic cells in response to microbial stimuli. Clin Exp Immunol (2005) 139:245-56. doi:10.1111/j.1365-2249.2004.02674.x
-
(2005)
Clin Exp Immunol
, vol.139
, pp. 245-256
-
-
Rigby, R.J.1
Knight, S.C.2
Kamm, M.A.3
Stagg, A.J.4
-
109
-
-
34447107856
-
Inducible IL-12-producing B cells regulate Th2-mediated intestinal inflammation
-
Sugimoto K, Ogawa A, Shimomura Y, Nagahama K, Mizoguchi A, Bhan AK. Inducible IL-12-producing B cells regulate Th2-mediated intestinal inflammation. Gastroenterology (2007) 133:124-36. doi:10.1053/j.gastro.2007.03.112
-
(2007)
Gastroenterology
, vol.133
, pp. 124-136
-
-
Sugimoto, K.1
Ogawa, A.2
Shimomura, Y.3
Nagahama, K.4
Mizoguchi, A.5
Bhan, A.K.6
-
110
-
-
84896759216
-
The dichotomous pattern of IL-12r and IL-23R expression elucidates the role of IL-12 and IL-23 in inflammation
-
Chognard G, Bellemare L, Pelletier AN, Dominguez-Punaro MC, Beauchamp C, Guyon MJ, et al. The dichotomous pattern of IL-12r and IL-23R expression elucidates the role of IL-12 and IL-23 in inflammation. PLoS One (2014) 9:e89092. doi:10.1371/journal.pone.0089092
-
(2014)
PLoS One
, vol.9
-
-
Chognard, G.1
Bellemare, L.2
Pelletier, A.N.3
Dominguez-Punaro, M.C.4
Beauchamp, C.5
Guyon, M.J.6
-
111
-
-
77957942243
-
Anticancer properties of the IL-12 family-focus on colorectal cancer
-
Engel MA, Neurath MF. Anticancer properties of the IL-12 family-focus on colorectal cancer. Curr Med Chem (2010) 17:3303-8. doi:10.2174/092986710793176366
-
(2010)
Curr Med Chem
, vol.17
, pp. 3303-3308
-
-
Engel, M.A.1
Neurath, M.F.2
-
112
-
-
0026691714
-
Regulation of human cytolytic lymphocyte responses by interleukin-12
-
Gately MK, Wolitzky AG, Quinn PM, Chizzonite R. Regulation of human cytolytic lymphocyte responses by interleukin-12. Cell Immunol (1992) 143:127-42. doi:10.1016/0008-8749(92)90011-D
-
(1992)
Cell Immunol
, vol.143
, pp. 127-142
-
-
Gately, M.K.1
Wolitzky, A.G.2
Quinn, P.M.3
Chizzonite, R.4
-
113
-
-
0028043326
-
Interleukin-12: a cytokine produced by antigen-presenting cells with immunoregulatory functions in the generation of T-helper cells type 1 and cytotoxic lymphocytes
-
Trinchieri G. Interleukin-12: a cytokine produced by antigen-presenting cells with immunoregulatory functions in the generation of T-helper cells type 1 and cytotoxic lymphocytes. Blood (1994) 84:4008-27
-
(1994)
Blood
, vol.84
, pp. 4008-4027
-
-
Trinchieri, G.1
-
114
-
-
0029040855
-
Regulation of interleukin-12 expression in human monocytes: selective priming by interferon-gamma of lipopolysaccharide-inducible p35 and p40 genes
-
Hayes MP, Wang J, Norcross MA. Regulation of interleukin-12 expression in human monocytes: selective priming by interferon-gamma of lipopolysaccharide-inducible p35 and p40 genes. Blood (1995) 86:646-50
-
(1995)
Blood
, vol.86
, pp. 646-650
-
-
Hayes, M.P.1
Wang, J.2
Norcross, M.A.3
-
115
-
-
0028970060
-
Interleukin-12: a proinflammatory cytokine with immunoregulatory functions that bridge innate resistance and antigen-specific adaptive immunity
-
Trinchieri G. Interleukin-12: a proinflammatory cytokine with immunoregulatory functions that bridge innate resistance and antigen-specific adaptive immunity. Annu Rev Immunol (1995) 13:251-76. doi:10.1146/annurev.iy.13.040195.001343
-
(1995)
Annu Rev Immunol
, vol.13
, pp. 251-276
-
-
Trinchieri, G.1
-
116
-
-
0035294299
-
Immunization of HLA-A2+ melanoma patients with MAGE-3 or MelanA peptide-pulsed autologous peripheral blood mononuclear cells plus recombinant human interleukin 12
-
Gajewski TF, Fallarino F, Ashikari A, Sherman M. Immunization of HLA-A2+ melanoma patients with MAGE-3 or MelanA peptide-pulsed autologous peripheral blood mononuclear cells plus recombinant human interleukin 12. Clin Cancer Res (2001) 7:895s-901s
-
(2001)
Clin Cancer Res
, vol.7
, pp. 895s-901s
-
-
Gajewski, T.F.1
Fallarino, F.2
Ashikari, A.3
Sherman, M.4
-
117
-
-
2342570309
-
Phase I trial of intratumoral injection of an adenovirus encoding interleukin-12 for advanced digestive tumors
-
Sangro B, Mazzolini G, Ruiz J, Herraiz M, Quiroga J, Herrero I, et al. Phase I trial of intratumoral injection of an adenovirus encoding interleukin-12 for advanced digestive tumors. J Clin Oncol (2004) 22:1389-97. doi:10.1200/JCO.2004.04.059
-
(2004)
J Clin Oncol
, vol.22
, pp. 1389-1397
-
-
Sangro, B.1
Mazzolini, G.2
Ruiz, J.3
Herraiz, M.4
Quiroga, J.5
Herrero, I.6
-
118
-
-
70949093473
-
A phase I trial of paclitaxel and trastuzumab in combination with interleukin-12 in patients with HER2/neu-expressing malignancies
-
Bekaii-Saab TS, Roda JM, Guenterberg KD, Ramaswamy B, Young DC, Ferketich AK, et al. A phase I trial of paclitaxel and trastuzumab in combination with interleukin-12 in patients with HER2/neu-expressing malignancies. Mol Cancer Ther (2009) 8:2983-91. doi:10.1158/1535-7163.MCT-09-0820
-
(2009)
Mol Cancer Ther
, vol.8
, pp. 2983-2991
-
-
Bekaii-Saab, T.S.1
Roda, J.M.2
Guenterberg, K.D.3
Ramaswamy, B.4
Young, D.C.5
Ferketich, A.K.6
-
119
-
-
84899950432
-
Interleukin 12: still a promising candidate for tumor immunotherapy?
-
Lasek W, Zagozdzon R, Jakobisiak M. Interleukin 12: still a promising candidate for tumor immunotherapy? Cancer Immunol Immunother (2014) 63:419-35. doi:10.1007/s00262-014-1523-1
-
(2014)
Cancer Immunol Immunother
, vol.63
, pp. 419-435
-
-
Lasek, W.1
Zagozdzon, R.2
Jakobisiak, M.3
-
120
-
-
84944447448
-
IL-15 suppresses colitis-associated colon carcinogenesis by inducing antitumor immunity
-
Bahri R, Pateras IS, D'Orlando O, Goyeneche-Patino DA, Campbell M, Polansky JK, et al. IL-15 suppresses colitis-associated colon carcinogenesis by inducing antitumor immunity. Oncoimmunology (2015) 4:e1002721. doi:10.1080/2162402X.2014.1002721
-
(2015)
Oncoimmunology
, vol.4
-
-
Bahri, R.1
Pateras, I.S.2
D'Orlando, O.3
Goyeneche-Patino, D.A.4
Campbell, M.5
Polansky, J.K.6
-
121
-
-
11244255868
-
Role of trans-cellular IL-15 presentation in the activation of NK cell-mediated killing, which leads to enhanced tumor immunosurveillance
-
Kobayashi H, Dubois S, Sato N, Sabzevari H, Sakai Y, Waldmann TA, et al. Role of trans-cellular IL-15 presentation in the activation of NK cell-mediated killing, which leads to enhanced tumor immunosurveillance. Blood (2005) 105:721-7. doi:10.1182/blood-2003-12-4187
-
(2005)
Blood
, vol.105
, pp. 721-727
-
-
Kobayashi, H.1
Dubois, S.2
Sato, N.3
Sabzevari, H.4
Sakai, Y.5
Waldmann, T.A.6
-
122
-
-
78650328102
-
Simultaneous blockade of multiple immune system inhibitory checkpoints enhances antitumor activity mediated by interleukin-15 in a murine metastatic colon carcinoma model
-
Yu P, Steel JC, Zhang M, Morris JC, Waldmann TA. Simultaneous blockade of multiple immune system inhibitory checkpoints enhances antitumor activity mediated by interleukin-15 in a murine metastatic colon carcinoma model. Clin Cancer Res (2010) 16:6019-28. doi:10.1158/1078-0432.CCR-10-1966
-
(2010)
Clin Cancer Res
, vol.16
, pp. 6019-6028
-
-
Yu, P.1
Steel, J.C.2
Zhang, M.3
Morris, J.C.4
Waldmann, T.A.5
-
123
-
-
66149114495
-
Interleukin-15 combined with an anti-CD40 antibody provides enhanced therapeutic efficacy for murine models of colon cancer
-
Zhang M, Yao Z, Dubois S, Ju W, Muller JR, Waldmann TA. Interleukin-15 combined with an anti-CD40 antibody provides enhanced therapeutic efficacy for murine models of colon cancer. Proc Natl Acad Sci U S A (2009) 106:7513-8. doi:10.1073/pnas.0902637106
-
(2009)
Proc Natl Acad Sci U S A
, vol.106
, pp. 7513-7518
-
-
Zhang, M.1
Yao, Z.2
Dubois, S.3
Ju, W.4
Muller, J.R.5
Waldmann, T.A.6
-
125
-
-
84899005149
-
Molecular pathways: interleukin-15 signaling in health and in cancer
-
Mishra A, Sullivan L, Caligiuri MA. Molecular pathways: interleukin-15 signaling in health and in cancer. Clin Cancer Res (2014) 20:2044-50. doi:10.1158/1078-0432.CCR-12-3603
-
(2014)
Clin Cancer Res
, vol.20
, pp. 2044-2050
-
-
Mishra, A.1
Sullivan, L.2
Caligiuri, M.A.3
-
126
-
-
84948712534
-
IL-15 functions as a danger signal to regulate tissue-resident T cells and tissue destruction
-
Jabri B, Abadie V. IL-15 functions as a danger signal to regulate tissue-resident T cells and tissue destruction. Nat Rev Immunol (2015) 15:771-83. doi:10.1038/nri3919
-
(2015)
Nat Rev Immunol
, vol.15
, pp. 771-783
-
-
Jabri, B.1
Abadie, V.2
-
127
-
-
5644277476
-
Interleukin-17 family members and inflammation
-
Kolls JK, Linden A. Interleukin-17 family members and inflammation. Immunity (2004) 21:467-76. doi:10.1016/j.immuni.2004.08.018
-
(2004)
Immunity
, vol.21
, pp. 467-476
-
-
Kolls, J.K.1
Linden, A.2
-
128
-
-
84867526156
-
IL-17A in the tumor microenvironment of the human colorectal adenoma-carcinoma sequence
-
Cui G, Yuan A, Goll R, Florholmen J. IL-17A in the tumor microenvironment of the human colorectal adenoma-carcinoma sequence. Scand J Gastroenterol (2012) 47:1304-12. doi:10.3109/00365521.2012.725089
-
(2012)
Scand J Gastroenterol
, vol.47
, pp. 1304-1312
-
-
Cui, G.1
Yuan, A.2
Goll, R.3
Florholmen, J.4
-
129
-
-
84924624351
-
Interleukin-17FT7488 allele is associated with a decreased risk of colorectal cancer and tumor progression
-
Nemati K, Golmoghaddam H, Hosseini SV, Ghaderi A, Doroudchi M. Interleukin-17FT7488 allele is associated with a decreased risk of colorectal cancer and tumor progression. Gene (2015) 561:88-94. doi:10.1016/j.gene.2015.02.014
-
(2015)
Gene
, vol.561
, pp. 88-94
-
-
Nemati, K.1
Golmoghaddam, H.2
Hosseini, S.V.3
Ghaderi, A.4
Doroudchi, M.5
-
130
-
-
84901800888
-
Interleukin-17A modulates circulating tumor cells in tumor draining vein of colorectal cancers and affects metastases
-
Tseng JY, Yang CY, Liang SC, Liu RS, Yang SH, Lin JK, et al. Interleukin-17A modulates circulating tumor cells in tumor draining vein of colorectal cancers and affects metastases. Clin Cancer Res (2014) 20:2885-97. doi:10.1158/1078-0432.CCR-13-2162
-
(2014)
Clin Cancer Res
, vol.20
, pp. 2885-2897
-
-
Tseng, J.Y.1
Yang, C.Y.2
Liang, S.C.3
Liu, R.S.4
Yang, S.H.5
Lin, J.K.6
-
131
-
-
84885724091
-
Spatiotemporal dynamics of intratumoral immune cells reveal the immune landscape in human cancer
-
Bindea G, Mlecnik B, Tosolini M, Kirilovsky A, Waldner M, Obenauf AC, et al. Spatiotemporal dynamics of intratumoral immune cells reveal the immune landscape in human cancer. Immunity (2013) 39:782-95. doi:10.1016/j.immuni.2013.10.003
-
(2013)
Immunity
, vol.39
, pp. 782-795
-
-
Bindea, G.1
Mlecnik, B.2
Tosolini, M.3
Kirilovsky, A.4
Waldner, M.5
Obenauf, A.C.6
-
132
-
-
77950420796
-
Ablation of IL-17A abrogates progression of spontaneous intestinal tumorigenesis
-
Chae WJ, Gibson TF, Zelterman D, Hao L, Henegariu O, Bothwell AL. Ablation of IL-17A abrogates progression of spontaneous intestinal tumorigenesis. Proc Natl Acad Sci U S A (2010) 107:5540-4. doi:10.1073/pnas.0912675107
-
(2010)
Proc Natl Acad Sci U S A
, vol.107
, pp. 5540-5544
-
-
Chae, W.J.1
Gibson, T.F.2
Zelterman, D.3
Hao, L.4
Henegariu, O.5
Bothwell, A.L.6
-
133
-
-
84859602743
-
Role of IL-17A in the development of colitis-associated cancer
-
Hyun YS, Han DS, Lee AR, Eun CS, Youn J, Kim HY. Role of IL-17A in the development of colitis-associated cancer. Carcinogenesis (2012) 33:931-6. doi:10.1093/carcin/bgs106
-
(2012)
Carcinogenesis
, vol.33
, pp. 931-936
-
-
Hyun, Y.S.1
Han, D.S.2
Lee, A.R.3
Eun, C.S.4
Youn, J.5
Kim, H.Y.6
-
134
-
-
33748588423
-
The orphan nuclear receptor RORgammat directs the differentiation program of proinflammatory IL-17+ T helper cells
-
Ivanov II, McKenzie BS, Zhou L, Tadokoro CE, Lepelley A, Lafaille JJ, et al. The orphan nuclear receptor RORgammat directs the differentiation program of proinflammatory IL-17+ T helper cells. Cell (2006) 126:1121-33. doi:10.1016/j.cell.2006.07.035
-
(2006)
Cell
, vol.126
, pp. 1121-1133
-
-
Ivanov, I.I.1
McKenzie, B.S.2
Zhou, L.3
Tadokoro, C.E.4
Lepelley, A.5
Lafaille, J.J.6
-
135
-
-
84939893259
-
Elevated proinflammatory cytokine IL-17A in the adjacent tissues along the adenoma-carcinoma sequence
-
Cui G, Yang H, Zhao J, Yuan A, Florholmen J. Elevated proinflammatory cytokine IL-17A in the adjacent tissues along the adenoma-carcinoma sequence. Pathol Oncol Res (2015) 21:139-46. doi:10.1007/s12253-014-9799-1
-
(2015)
Pathol Oncol Res
, vol.21
, pp. 139-146
-
-
Cui, G.1
Yang, H.2
Zhao, J.3
Yuan, A.4
Florholmen, J.5
-
136
-
-
69949120571
-
A human colonic commensal promotes colon tumorigenesis via activation of T helper type 17 T cell responses
-
Wu S, Rhee KJ, Albesiano E, Rabizadeh S, Wu X, Yen HR, et al. A human colonic commensal promotes colon tumorigenesis via activation of T helper type 17 T cell responses. Nat Med (2009) 15:1016-22. doi:10.1038/nm.2015
-
(2009)
Nat Med
, vol.15
, pp. 1016-1022
-
-
Wu, S.1
Rhee, K.J.2
Albesiano, E.3
Rabizadeh, S.4
Wu, X.5
Yen, H.R.6
-
137
-
-
84866733757
-
CD8(+) T cells that produce interleukin-17 regulate myeloid-derived suppressor cells and are associated with survival time of patients with gastric cancer
-
Zhuang Y, Peng LS, Zhao YL, Shi Y, Mao XH, Chen W, et al. CD8(+) T cells that produce interleukin-17 regulate myeloid-derived suppressor cells and are associated with survival time of patients with gastric cancer. Gastroenterology (2012) 143:951e-62e. doi:10.1053/j.gastro.2012.06.010
-
(2012)
Gastroenterology
, vol.143
, pp. 951e-962e
-
-
Zhuang, Y.1
Peng, L.S.2
Zhao, Y.L.3
Shi, Y.4
Mao, X.H.5
Chen, W.6
-
138
-
-
84879571464
-
Innate lymphoid cells sustain colon cancer through production of interleukin-22 in a mouse model
-
Kirchberger S, Royston DJ, Boulard O, Thornton E, Franchini F, Szabady RL, et al. Innate lymphoid cells sustain colon cancer through production of interleukin-22 in a mouse model. J Exp Med (2013) 210:917-31. doi:10.1084/jem.20122308
-
(2013)
J Exp Med
, vol.210
, pp. 917-931
-
-
Kirchberger, S.1
Royston, D.J.2
Boulard, O.3
Thornton, E.4
Franchini, F.5
Szabady, R.L.6
-
139
-
-
84900482064
-
gammadeltaT17 cells promote the accumulation and expansion of myeloid-derived suppressor cells in human colorectal cancer
-
Wu P, Wu D, Ni C, Ye J, Chen W, Hu G, et al. gammadeltaT17 cells promote the accumulation and expansion of myeloid-derived suppressor cells in human colorectal cancer. Immunity (2014) 40:785-800. doi:10.1016/j.immuni.2014.03.013
-
(2014)
Immunity
, vol.40
, pp. 785-800
-
-
Wu, P.1
Wu, D.2
Ni, C.3
Ye, J.4
Chen, W.5
Hu, G.6
-
140
-
-
84918535539
-
Interleukin-17 receptor a signaling in transformed enterocytes promotes early colorectal tumorigenesis
-
Wang K, Kim MK, Di Caro G, Wong J, Shalapour S, Wan J, et al. Interleukin-17 receptor a signaling in transformed enterocytes promotes early colorectal tumorigenesis. Immunity (2014) 41:1052-63. doi:10.1016/j.immuni.2014.11.009
-
(2014)
Immunity
, vol.41
, pp. 1052-1063
-
-
Wang, K.1
Kim, M.K.2
Di Caro, G.3
Wong, J.4
Shalapour, S.5
Wan, J.6
-
141
-
-
84939856972
-
Distinctive expression pattern of interleukin-17 cytokine family members in colorectal cancer
-
Al-Samadi A, Moossavi S, Salem A, Sotoudeh M, Tuovinen SM, Konttinen YT, et al. Distinctive expression pattern of interleukin-17 cytokine family members in colorectal cancer. Tumour Biol (2015) 1-7. doi:10.1007/s13277-015-3941-x
-
(2015)
Tumour Biol
, pp. 1-7
-
-
Al-Samadi, A.1
Moossavi, S.2
Salem, A.3
Sotoudeh, M.4
Tuovinen, S.M.5
Konttinen, Y.T.6
-
142
-
-
84939209351
-
Involvement of IL17A, IL17F and IL23R polymorphisms in colorectal cancer therapy
-
Omrane I, Medimegh I, Baroudi O, Ayari H, Bedhiafi W, Stambouli N, et al. Involvement of IL17A, IL17F and IL23R polymorphisms in colorectal cancer therapy. PLoS One (2015) 10:e0128911. doi:10.1371/journal.pone.0128911
-
(2015)
PLoS One
, vol.10
-
-
Omrane, I.1
Medimegh, I.2
Baroudi, O.3
Ayari, H.4
Bedhiafi, W.5
Stambouli, N.6
-
143
-
-
84859578124
-
A protective role by interleukin-17F in colon tumorigenesis
-
Tong Z, Yang XO, Yan H, Liu W, Niu X, Shi Y, et al. A protective role by interleukin-17F in colon tumorigenesis. PLoS One (2012) 7:e34959. doi:10.1371/journal.pone.0034959
-
(2012)
PLoS One
, vol.7
-
-
Tong, Z.1
Yang, X.O.2
Yan, H.3
Liu, W.4
Niu, X.5
Shi, Y.6
-
144
-
-
0035887627
-
Cutting edge: IL-17F, a novel cytokine selectively expressed in activated T cells and monocytes, regulates angiogenesis and endothelial cell cytokine production
-
Starnes T, Robertson MJ, Sledge G, Kelich S, Nakshatri H, Broxmeyer HE, et al. Cutting edge: IL-17F, a novel cytokine selectively expressed in activated T cells and monocytes, regulates angiogenesis and endothelial cell cytokine production. J Immunol (2001) 167:4137-40. doi:10.4049/jimmunol.167.8.4137
-
(2001)
J Immunol
, vol.167
, pp. 4137-4140
-
-
Starnes, T.1
Robertson, M.J.2
Sledge, G.3
Kelich, S.4
Nakshatri, H.5
Broxmeyer, H.E.6
-
145
-
-
68849084891
-
Structure and signalling in the IL-17 receptor family
-
Gaffen SL. Structure and signalling in the IL-17 receptor family. Nat Rev Immunol (2009) 9:556-67. doi:10.1038/nri2586
-
(2009)
Nat Rev Immunol
, vol.9
, pp. 556-567
-
-
Gaffen, S.L.1
-
146
-
-
85028276122
-
Th17-type cytokines, IL-6 and TNF-alpha synergistically activate STAT3 and NF-kB to promote colorectal cancer cell growth
-
De Simone V, Franze E, Ronchetti G, Colantoni A, Fantini MC, Di Fusco D, et al. Th17-type cytokines, IL-6 and TNF-alpha synergistically activate STAT3 and NF-kB to promote colorectal cancer cell growth. Oncogene (2015) 34:3493-503. doi:10.1038/onc.2014.286
-
(2015)
Oncogene
, vol.34
, pp. 3493-3503
-
-
De Simone, V.1
Franze, E.2
Ronchetti, G.3
Colantoni, A.4
Fantini, M.C.5
Di Fusco, D.6
-
147
-
-
37549051684
-
Heterozygosity for interleukin-18-607 A/C polymorphism is associated with risk for colorectal cancer
-
Nikiteas N, Yannopoulos A, Chatzitheofylaktou A, Tsigris C. Heterozygosity for interleukin-18-607 A/C polymorphism is associated with risk for colorectal cancer. Anticancer Res (2007) 27:3849-53
-
(2007)
Anticancer Res
, vol.27
, pp. 3849-3853
-
-
Nikiteas, N.1
Yannopoulos, A.2
Chatzitheofylaktou, A.3
Tsigris, C.4
-
148
-
-
0033064554
-
Modulation of interleukin-18 expression in human colon carcinoma: consequences for tumor immune surveillance
-
Pages F, Berger A, Henglein B, Piqueras B, Danel C, Zinzindohoue F, et al. Modulation of interleukin-18 expression in human colon carcinoma: consequences for tumor immune surveillance. Int J Cancer (1999) 84:326-30. doi:10.1002/(SICI)1097-0215(19990621)84:3<326::AID-IJC22>3.3.CO;2-B
-
(1999)
Int J Cancer
, vol.84
, pp. 326-330
-
-
Pages, F.1
Berger, A.2
Henglein, B.3
Piqueras, B.4
Danel, C.5
Zinzindohoue, F.6
-
149
-
-
42749096082
-
Genetic analysis of innate immunity in Crohn's disease and ulcerative colitis identifies two susceptibility loci harboring CARD9 and IL18RAP
-
Zhernakova A, Festen EM, Franke L, Trynka G, van Diemen CC, Monsuur AJ, et al. Genetic analysis of innate immunity in Crohn's disease and ulcerative colitis identifies two susceptibility loci harboring CARD9 and IL18RAP. Am J Hum Genet (2008) 82:1202-10. doi:10.1016/j.ajhg.2008.03.016
-
(2008)
Am J Hum Genet
, vol.82
, pp. 1202-1210
-
-
Zhernakova, A.1
Festen, E.M.2
Franke, L.3
Trynka, G.4
van Diemen, C.C.5
Monsuur, A.J.6
-
150
-
-
77953464026
-
Nlrp3: an immune sensor of cellular stress and infection
-
Lamkanfi M, Kanneganti TD. Nlrp3: an immune sensor of cellular stress and infection. Int J Biochem Cell Biol (2010) 42:792-5. doi:10.1016/j.biocel.2010.01.008
-
(2010)
Int J Biochem Cell Biol
, vol.42
, pp. 792-795
-
-
Lamkanfi, M.1
Kanneganti, T.D.2
-
151
-
-
78650624793
-
Innate immune mechanisms of colitis and colitis-associated colorectal cancer
-
Saleh M, Trinchieri G. Innate immune mechanisms of colitis and colitis-associated colorectal cancer. Nat Rev Immunol (2011) 11:9-20. doi:10.1038/nri2891
-
(2011)
Nat Rev Immunol
, vol.11
, pp. 9-20
-
-
Saleh, M.1
Trinchieri, G.2
-
152
-
-
77955350419
-
MyD88-mediated signaling prevents development of adenocarcinomas of the colon: role of interleukin 18
-
Salcedo R, Worschech A, Cardone M, Jones Y, Gyulai Z, Dai RM, et al. MyD88-mediated signaling prevents development of adenocarcinomas of the colon: role of interleukin 18. J Exp Med (2010) 207:1625-36. doi:10.1084/jem.20100199
-
(2010)
J Exp Med
, vol.207
, pp. 1625-1636
-
-
Salcedo, R.1
Worschech, A.2
Cardone, M.3
Jones, Y.4
Gyulai, Z.5
Dai, R.M.6
-
153
-
-
78049488908
-
IL-18 production downstream of the Nlrp3 inflammasome confers protection against colorectal tumor formation
-
Zaki MH, Vogel P, Body-Malapel M, Lamkanfi M, Kanneganti TD. IL-18 production downstream of the Nlrp3 inflammasome confers protection against colorectal tumor formation. J Immunol (2010) 185:4912-20. doi:10.4049/jimmunol.1002046
-
(2010)
J Immunol
, vol.185
, pp. 4912-4920
-
-
Zaki, M.H.1
Vogel, P.2
Body-Malapel, M.3
Lamkanfi, M.4
Kanneganti, T.D.5
-
154
-
-
84939570120
-
Epithelial-derived IL-18 regulates Th17 cell differentiation and Foxp3(+) Treg cell function in the intestine
-
Harrison OJ, Srinivasan N, Pott J, Schiering C, Krausgruber T, Ilott NE, et al. Epithelial-derived IL-18 regulates Th17 cell differentiation and Foxp3(+) Treg cell function in the intestine. Mucosal Immunol (2015) 8:1226-36. doi:10.1038/mi.2015.13
-
(2015)
Mucosal Immunol
, vol.8
, pp. 1226-1236
-
-
Harrison, O.J.1
Srinivasan, N.2
Pott, J.3
Schiering, C.4
Krausgruber, T.5
Ilott, N.E.6
-
155
-
-
77949965210
-
Control of intestinal homeostasis, colitis, and colitis-associated colorectal cancer by the inflammatory caspases
-
Dupaul-Chicoine J, Yeretssian G, Doiron K, Bergstrom KS, McIntire CR, LeBlanc PM, et al. Control of intestinal homeostasis, colitis, and colitis-associated colorectal cancer by the inflammatory caspases. Immunity (2010) 32:367-78. doi:10.1016/j.immuni.2010.02.012
-
(2010)
Immunity
, vol.32
, pp. 367-378
-
-
Dupaul-Chicoine, J.1
Yeretssian, G.2
Doiron, K.3
Bergstrom, K.S.4
McIntire, C.R.5
LeBlanc, P.M.6
-
156
-
-
77950002937
-
The NLRP3 inflammasome protects against loss of epithelial integrity and mortality during experimental colitis
-
Zaki MH, Boyd KL, Vogel P, Kastan MB, Lamkanfi M, Kanneganti TD. The NLRP3 inflammasome protects against loss of epithelial integrity and mortality during experimental colitis. Immunity (2010) 32:379-91. doi:10.1016/j.immuni.2010.03.003
-
(2010)
Immunity
, vol.32
, pp. 379-391
-
-
Zaki, M.H.1
Boyd, K.L.2
Vogel, P.3
Kastan, M.B.4
Lamkanfi, M.5
Kanneganti, T.D.6
-
157
-
-
84868615556
-
IL-22BP is regulated by the inflammasome and modulates tumorigenesis in the intestine
-
Huber S, Gagliani N, Zenewicz LA, Huber FJ, Bosurgi L, Hu B, et al. IL-22BP is regulated by the inflammasome and modulates tumorigenesis in the intestine. Nature (2012) 491:259-63. doi:10.1038/nature11535
-
(2012)
Nature
, vol.491
, pp. 259-263
-
-
Huber, S.1
Gagliani, N.2
Zenewicz, L.A.3
Huber, F.J.4
Bosurgi, L.5
Hu, B.6
-
158
-
-
0034453608
-
Proinflammatory and antitumor properties of interleukin-18 in the gastrointestinal tract
-
Pages F, Berger A, Lebel-Binay S, Zinzindohoue F, Danel C, Piqueras B, et al. Proinflammatory and antitumor properties of interleukin-18 in the gastrointestinal tract. Immunol Lett (2000) 75:9-14. doi:10.1016/S0165-2478(00)00285-6
-
(2000)
Immunol Lett
, vol.75
, pp. 9-14
-
-
Pages, F.1
Berger, A.2
Lebel-Binay, S.3
Zinzindohoue, F.4
Danel, C.5
Piqueras, B.6
-
159
-
-
80055105733
-
Involvement of interleukin-21 in the regulation of colitis-associated colon cancer
-
Stolfi C, Rizzo A, Franze E, Rotondi A, Fantini MC, Sarra M, et al. Involvement of interleukin-21 in the regulation of colitis-associated colon cancer. J Exp Med (2011) 208:2279-90. doi:10.1084/jem.20111106
-
(2011)
J Exp Med
, vol.208
, pp. 2279-2290
-
-
Stolfi, C.1
Rizzo, A.2
Franze, E.3
Rotondi, A.4
Fantini, M.C.5
Sarra, M.6
-
160
-
-
84857786741
-
A phase 1 trial of recombinant human IL-21 in combination with cetuximab in patients with metastatic colorectal cancer
-
Steele N, Anthony A, Saunders M, Esmarck B, Ehrnrooth E, Kristjansen PE, et al. A phase 1 trial of recombinant human IL-21 in combination with cetuximab in patients with metastatic colorectal cancer. Br J Cancer (2012) 106:793-8. doi:10.1038/bjc.2011.599
-
(2012)
Br J Cancer
, vol.106
, pp. 793-798
-
-
Steele, N.1
Anthony, A.2
Saunders, M.3
Esmarck, B.4
Ehrnrooth, E.5
Kristjansen, P.E.6
-
161
-
-
80655125038
-
Interleukin 21 controls tumour growth and tumour immunosurveillance in colitis-associated tumorigenesis in mice
-
Jauch D, Martin M, Schiechl G, Kesselring R, Schlitt HJ, Geissler EK, et al. Interleukin 21 controls tumour growth and tumour immunosurveillance in colitis-associated tumorigenesis in mice. Gut (2011) 60:1678-86. doi:10.1136/gutjnl-2011-300612
-
(2011)
Gut
, vol.60
, pp. 1678-1686
-
-
Jauch, D.1
Martin, M.2
Schiechl, G.3
Kesselring, R.4
Schlitt, H.J.5
Geissler, E.K.6
-
162
-
-
84878066887
-
Role of IL-21 and IL-21 receptor on B cells in HIV infection
-
Pallikkuth S, Parmigiani A, Pahwa S. Role of IL-21 and IL-21 receptor on B cells in HIV infection. Crit Rev Immunol (2012) 32:173-95. doi:10.1615/CritRevImmunol.v32.i2.50
-
(2012)
Crit Rev Immunol
, vol.32
, pp. 173-195
-
-
Pallikkuth, S.1
Parmigiani, A.2
Pahwa, S.3
-
163
-
-
84899979288
-
Interleukin-21: a double-edged sword with therapeutic potential
-
Spolski R, Leonard WJ. Interleukin-21: a double-edged sword with therapeutic potential. Nat Rev Drug Discov (2014) 13:379-95. doi:10.1038/nrd4296
-
(2014)
Nat Rev Drug Discov
, vol.13
, pp. 379-395
-
-
Spolski, R.1
Leonard, W.J.2
-
164
-
-
2542595794
-
IL-21 enhances and sustains CD8+ T cell responses to achieve durable tumor immunity: comparative evaluation of IL-2, IL-15, and IL-21
-
Moroz A, Eppolito C, Li Q, Tao J, Clegg CH, Shrikant PA. IL-21 enhances and sustains CD8+ T cell responses to achieve durable tumor immunity: comparative evaluation of IL-2, IL-15, and IL-21. J Immunol (2004) 173:900-9. doi:10.4049/jimmunol.173.2.900
-
(2004)
J Immunol
, vol.173
, pp. 900-909
-
-
Moroz, A.1
Eppolito, C.2
Li, Q.3
Tao, J.4
Clegg, C.H.5
Shrikant, P.A.6
-
165
-
-
40049093723
-
Interleukin 21: combination strategies for cancer therapy
-
Skak K, Kragh M, Hausman D, Smyth MJ, Sivakumar PV. Interleukin 21: combination strategies for cancer therapy. Nat Rev Drug Discov (2008) 7:231-40. doi:10.1038/nrd2482
-
(2008)
Nat Rev Drug Discov
, vol.7
, pp. 231-240
-
-
Skak, K.1
Kragh, M.2
Hausman, D.3
Smyth, M.J.4
Sivakumar, P.V.5
-
166
-
-
84927654352
-
Th22 cell accumulation is associated with colorectal cancer development
-
Huang YH, Cao YF, Jiang ZY, Zhang S, Gao F. Th22 cell accumulation is associated with colorectal cancer development. World J Gastroenterol (2015) 21:4216-24. doi:10.3748/wjg.v21.i14.4216
-
(2015)
World J Gastroenterol
, vol.21
, pp. 4216-4224
-
-
Huang, Y.H.1
Cao, Y.F.2
Jiang, Z.Y.3
Zhang, S.4
Gao, F.5
-
167
-
-
84908470068
-
Interleukin 22 protects colorectal cancer cells from chemotherapy by activating the STAT3 pathway and inducing autocrine expression of interleukin 8
-
Wu T, Wang Z, Liu Y, Mei Z, Wang G, Liang Z, et al. Interleukin 22 protects colorectal cancer cells from chemotherapy by activating the STAT3 pathway and inducing autocrine expression of interleukin 8. Clin Immunol (2014) 154:116-26. doi:10.1016/j.clim.2014.07.005
-
(2014)
Clin Immunol
, vol.154
, pp. 116-126
-
-
Wu, T.1
Wang, Z.2
Liu, Y.3
Mei, Z.4
Wang, G.5
Liang, Z.6
-
168
-
-
77955718188
-
Interleukin-22 genetic polymorphisms and risk of colon cancer
-
Thompson CL, Plummer SJ, Tucker TC, Casey G, Li L. Interleukin-22 genetic polymorphisms and risk of colon cancer. Cancer Causes Control (2010) 21:1165-70. doi:10.1007/s10552-010-9542-5
-
(2010)
Cancer Causes Control
, vol.21
, pp. 1165-1170
-
-
Thompson, C.L.1
Plummer, S.J.2
Tucker, T.C.3
Casey, G.4
Li, L.5
-
169
-
-
38849141814
-
IL-22 ameliorates intestinal inflammation in a mouse model of ulcerative colitis
-
Sugimoto K, Ogawa A, Mizoguchi E, Shimomura Y, Andoh A, Bhan AK, et al. IL-22 ameliorates intestinal inflammation in a mouse model of ulcerative colitis. J Clin Invest (2008) 118:534-44. doi:10.1172/JCI33194
-
(2008)
J Clin Invest
, vol.118
, pp. 534-544
-
-
Sugimoto, K.1
Ogawa, A.2
Mizoguchi, E.3
Shimomura, Y.4
Andoh, A.5
Bhan, A.K.6
-
170
-
-
57449090428
-
Innate and adaptive interleukin-22 protects mice from inflammatory bowel disease
-
Zenewicz LA, Yancopoulos GD, Valenzuela DM, Murphy AJ, Stevens S, Flavell RA. Innate and adaptive interleukin-22 protects mice from inflammatory bowel disease. Immunity (2008) 29:947-57. doi:10.1016/j.immuni.2008.11.003
-
(2008)
Immunity
, vol.29
, pp. 947-957
-
-
Zenewicz, L.A.1
Yancopoulos, G.D.2
Valenzuela, D.M.3
Murphy, A.J.4
Stevens, S.5
Flavell, R.A.6
-
171
-
-
67650474246
-
STAT3 links IL-22 signaling in intestinal epithelial cells to mucosal wound healing
-
Pickert G, Neufert C, Leppkes M, Zheng Y, Wittkopf N, Warntjen M, et al. STAT3 links IL-22 signaling in intestinal epithelial cells to mucosal wound healing. J Exp Med (2009) 206:1465-72. doi:10.1084/jem.20082683
-
(2009)
J Exp Med
, vol.206
, pp. 1465-1472
-
-
Pickert, G.1
Neufert, C.2
Leppkes, M.3
Zheng, Y.4
Wittkopf, N.5
Warntjen, M.6
-
172
-
-
84900459331
-
IL-22(+)CD4(+) T cells promote colorectal cancer stemness via STAT3 transcription factor activation and induction of the methyltransferase DOT1L
-
Kryczek I, Lin Y, Nagarsheth N, Peng D, Zhao L, Zhao E, et al. IL-22(+)CD4(+) T cells promote colorectal cancer stemness via STAT3 transcription factor activation and induction of the methyltransferase DOT1L. Immunity (2014) 40:772-84. doi:10.1016/j.immuni.2014.03.010
-
(2014)
Immunity
, vol.40
, pp. 772-784
-
-
Kryczek, I.1
Lin, Y.2
Nagarsheth, N.3
Peng, D.4
Zhao, L.5
Zhao, E.6
-
173
-
-
84957557636
-
IL10R2 overexpression promotes IL22/STAT3 signaling in colorectal carcinogenesis
-
Khare V, Paul G, Movadat O, Frick A, Jambrich M, Krnjic A, et al. IL10R2 overexpression promotes IL22/STAT3 signaling in colorectal carcinogenesis. Cancer Immunol Res (2015) 3:1227-35. doi:10.1158/2326-6066.CIR-15-0031
-
(2015)
Cancer Immunol Res
, vol.3
, pp. 1227-1235
-
-
Khare, V.1
Paul, G.2
Movadat, O.3
Frick, A.4
Jambrich, M.5
Krnjic, A.6
-
174
-
-
84900453541
-
IL-22 gets to the stem of colorectal cancer
-
Koltsova EK, Grivennikov SI. IL-22 gets to the stem of colorectal cancer. Immunity (2014) 40:639-41. doi:10.1016/j.immuni.2014.04.014
-
(2014)
Immunity
, vol.40
, pp. 639-641
-
-
Koltsova, E.K.1
Grivennikov, S.I.2
-
175
-
-
77953522676
-
Elevated serum level of IL-23 correlates with expression of VEGF in human colorectal carcinoma
-
Ljujic B, Radosavljevic G, Jovanovic I, Pavlovic S, Zdravkovic N, Milovanovic M, et al. Elevated serum level of IL-23 correlates with expression of VEGF in human colorectal carcinoma. Arch Med Res (2010) 41:182-9. doi:10.1016/j.arcmed.2010.02.009
-
(2010)
Arch Med Res
, vol.41
, pp. 182-189
-
-
Ljujic, B.1
Radosavljevic, G.2
Jovanovic, I.3
Pavlovic, S.4
Zdravkovic, N.5
Milovanovic, M.6
-
176
-
-
33746534417
-
IL-23 promotes tumour incidence and growth
-
Langowski JL, Zhang X, Wu L, Mattson JD, Chen T, Smith K, et al. IL-23 promotes tumour incidence and growth. Nature (2006) 442:461-5. doi:10.1038/nature04808
-
(2006)
Nature
, vol.442
, pp. 461-465
-
-
Langowski, J.L.1
Zhang, X.2
Wu, L.3
Mattson, J.D.4
Chen, T.5
Smith, K.6
-
177
-
-
84904679757
-
IL-23 selectively promotes the metastasis of colorectal carcinoma cells with impaired Socs3 expression via the STAT5 pathway
-
Zhang L, Li J, Li L, Zhang J, Wang X, Yang C, et al. IL-23 selectively promotes the metastasis of colorectal carcinoma cells with impaired Socs3 expression via the STAT5 pathway. Carcinogenesis (2014) 35:1330-40. doi:10.1093/carcin/bgu017
-
(2014)
Carcinogenesis
, vol.35
, pp. 1330-1340
-
-
Zhang, L.1
Li, J.2
Li, L.3
Zhang, J.4
Wang, X.5
Yang, C.6
-
178
-
-
45749107055
-
Unique CD14 intestinal macrophages contribute to the pathogenesis of Crohn disease via IL-23/IFN-gamma axis
-
Kamada N, Hisamatsu T, Okamoto S, Chinen H, Kobayashi T, Sato T, et al. Unique CD14 intestinal macrophages contribute to the pathogenesis of Crohn disease via IL-23/IFN-gamma axis. J Clin Invest (2008) 118:2269-80. doi:10.1172/JCI34610
-
(2008)
J Clin Invest
, vol.118
, pp. 2269-2280
-
-
Kamada, N.1
Hisamatsu, T.2
Okamoto, S.3
Chinen, H.4
Kobayashi, T.5
Sato, T.6
-
179
-
-
84857444876
-
Interleukin 23 production by intestinal CD103(+)CD11b(+) dendritic cells in response to bacterial flagellin enhances mucosal innate immune defense
-
Kinnebrew MA, Buffie CG, Diehl GE, Zenewicz LA, Leiner I, Hohl TM, et al. Interleukin 23 production by intestinal CD103(+)CD11b(+) dendritic cells in response to bacterial flagellin enhances mucosal innate immune defense. Immunity (2012) 36:276-87. doi:10.1016/j.immuni.2011.12.011
-
(2012)
Immunity
, vol.36
, pp. 276-287
-
-
Kinnebrew, M.A.1
Buffie, C.G.2
Diehl, G.E.3
Zenewicz, L.A.4
Leiner, I.5
Hohl, T.M.6
-
180
-
-
84937622124
-
Tissue-infiltrating neutrophils represent the main source of IL-23 in the colon of patients with IBD
-
Kvedaraite E, Lourda M, Idestrom M, Chen P, Olsson-Akefeldt S, Forkel M, et al. Tissue-infiltrating neutrophils represent the main source of IL-23 in the colon of patients with IBD. Gut (2015) 1-10. doi:10.1136/gutjnl-2014-309014
-
(2015)
Gut
, pp. 1-10
-
-
Kvedaraite, E.1
Lourda, M.2
Idestrom, M.3
Chen, P.4
Olsson-Akefeldt, S.5
Forkel, M.6
-
181
-
-
77955890952
-
Interleukin-23 drives intestinal inflammation through direct activity on T cells
-
Ahern PP, Schiering C, Buonocore S, McGeachy MJ, Cua DJ, Maloy KJ, et al. Interleukin-23 drives intestinal inflammation through direct activity on T cells. Immunity (2010) 33:279-88. doi:10.1016/j.immuni.2010.08.010
-
(2010)
Immunity
, vol.33
, pp. 279-288
-
-
Ahern, P.P.1
Schiering, C.2
Buonocore, S.3
McGeachy, M.J.4
Cua, D.J.5
Maloy, K.J.6
-
182
-
-
79958277385
-
IL-23-responsive innate lymphoid cells are increased in inflammatory bowel disease
-
Geremia A, Arancibia-Carcamo CV, Fleming MP, Rust N, Singh B, Mortensen NJ, et al. IL-23-responsive innate lymphoid cells are increased in inflammatory bowel disease. J Exp Med (2011) 208:1127-33. doi:10.1084/jem.20101712
-
(2011)
J Exp Med
, vol.208
, pp. 1127-1133
-
-
Geremia, A.1
Arancibia-Carcamo, C.V.2
Fleming, M.P.3
Rust, N.4
Singh, B.5
Mortensen, N.J.6
-
183
-
-
84906571227
-
The alarmin IL-33 promotes regulatory T-cell function in the intestine
-
Schiering C, Krausgruber T, Chomka A, Frohlich A, Adelmann K, Wohlfert EA, et al. The alarmin IL-33 promotes regulatory T-cell function in the intestine. Nature (2014) 513:564-8. doi:10.1038/nature13577
-
(2014)
Nature
, vol.513
, pp. 564-568
-
-
Schiering, C.1
Krausgruber, T.2
Chomka, A.3
Frohlich, A.4
Adelmann, K.5
Wohlfert, E.A.6
-
184
-
-
33750505009
-
Interleukin-23 drives innate and T cell-mediated intestinal inflammation
-
Hue S, Ahern P, Buonocore S, Kullberg MC, Cua DJ, McKenzie BS, et al. Interleukin-23 drives innate and T cell-mediated intestinal inflammation. J Exp Med (2006) 203:2473-83. doi:10.1084/jem.20061099
-
(2006)
J Exp Med
, vol.203
, pp. 2473-2483
-
-
Hue, S.1
Ahern, P.2
Buonocore, S.3
Kullberg, M.C.4
Cua, D.J.5
McKenzie, B.S.6
-
185
-
-
33750530394
-
IL-23 plays a key role in Helicobacter hepaticus-induced T cell-dependent colitis
-
Kullberg MC, Jankovic D, Feng CG, Hue S, Gorelick PL, McKenzie BS, et al. IL-23 plays a key role in Helicobacter hepaticus-induced T cell-dependent colitis. J Exp Med (2006) 203:2485-94. doi:10.1084/jem.20061082
-
(2006)
J Exp Med
, vol.203
, pp. 2485-2494
-
-
Kullberg, M.C.1
Jankovic, D.2
Feng, C.G.3
Hue, S.4
Gorelick, P.L.5
McKenzie, B.S.6
-
186
-
-
33646397611
-
IL-23 is essential for T cell-mediated colitis and promotes inflammation via IL-17 and IL-6
-
Yen D, Cheung J, Scheerens H, Poulet F, McClanahan T, McKenzie B, et al. IL-23 is essential for T cell-mediated colitis and promotes inflammation via IL-17 and IL-6. J Clin Invest (2006) 116:1310-6. doi:10.1172/JCI21404
-
(2006)
J Clin Invest
, vol.116
, pp. 1310-1316
-
-
Yen, D.1
Cheung, J.2
Scheerens, H.3
Poulet, F.4
McClanahan, T.5
McKenzie, B.6
-
187
-
-
75549087056
-
Disease-associated functions of IL-33: the new kid in the IL-1 family
-
Liew FY, Pitman NI, McInnes IB. Disease-associated functions of IL-33: the new kid in the IL-1 family. Nat Rev Immunol (2010) 10:103-10. doi:10.1038/nri2692
-
(2010)
Nat Rev Immunol
, vol.10
, pp. 103-110
-
-
Liew, F.Y.1
Pitman, N.I.2
McInnes, I.B.3
-
188
-
-
78649821588
-
IL-33 is a crucial amplifier of innate rather than acquired immunity
-
Oboki K, Ohno T, Kajiwara N, Arae K, Morita H, Ishii A, et al. IL-33 is a crucial amplifier of innate rather than acquired immunity. Proc Natl Acad Sci U S A (2010) 107:18581-6. doi:10.1073/pnas.1003059107
-
(2010)
Proc Natl Acad Sci U S A
, vol.107
, pp. 18581-18586
-
-
Oboki, K.1
Ohno, T.2
Kajiwara, N.3
Arae, K.4
Morita, H.5
Ishii, A.6
-
189
-
-
84873716709
-
Mechanisms of IL-33 processing and secretion: differences and similarities between IL-1 family members
-
Lefrancais E, Cayrol C. Mechanisms of IL-33 processing and secretion: differences and similarities between IL-1 family members. Eur Cytokine Netw (2012) 23:120-7. doi:10.1684/ecn.2012.0320
-
(2012)
Eur Cytokine Netw
, vol.23
, pp. 120-127
-
-
Lefrancais, E.1
Cayrol, C.2
-
190
-
-
84857134135
-
IL-33 is processed into mature bioactive forms by neutrophil elastase and cathepsin G
-
Lefrancais E, Roga S, Gautier V, Gonzalez-de-Peredo A, Monsarrat B, Girard JP, et al. IL-33 is processed into mature bioactive forms by neutrophil elastase and cathepsin G. Proc Natl Acad Sci U S A (2012) 109:1673-8. doi:10.1073/pnas.1115884109
-
(2012)
Proc Natl Acad Sci U S A
, vol.109
, pp. 1673-1678
-
-
Lefrancais, E.1
Roga, S.2
Gautier, V.3
Gonzalez-de-Peredo, A.4
Monsarrat, B.5
Girard, J.P.6
-
191
-
-
77952324145
-
Epithelial-derived IL-33 and its receptor ST2 are dysregulated in ulcerative colitis and in experimental Th1/Th2 driven enteritis
-
Pastorelli L, Garg RR, Hoang SB, Spina L, Mattioli B, Scarpa M, et al. Epithelial-derived IL-33 and its receptor ST2 are dysregulated in ulcerative colitis and in experimental Th1/Th2 driven enteritis. Proc Natl Acad Sci U S A (2010) 107:8017-22. doi:10.1073/pnas.0912678107
-
(2010)
Proc Natl Acad Sci U S A
, vol.107
, pp. 8017-8022
-
-
Pastorelli, L.1
Garg, R.R.2
Hoang, S.B.3
Spina, L.4
Mattioli, B.5
Scarpa, M.6
-
192
-
-
84887459057
-
Neutralisation of the interleukin-33/ST2 pathway ameliorates experimental colitis through enhancement of mucosal healing in mice
-
Sedhom MA, Pichery M, Murdoch JR, Foligne B, Ortega N, Normand S, et al. Neutralisation of the interleukin-33/ST2 pathway ameliorates experimental colitis through enhancement of mucosal healing in mice. Gut (2013) 62:1714-23. doi:10.1136/gutjnl-2011-301785
-
(2013)
Gut
, vol.62
, pp. 1714-1723
-
-
Sedhom, M.A.1
Pichery, M.2
Murdoch, J.R.3
Foligne, B.4
Ortega, N.5
Normand, S.6
-
193
-
-
84866386408
-
IL-33 attenuates development and perpetuation of chronic intestinal inflammation
-
Grobeta P, Doser K, Falk W, Obermeier F, Hofmann C. IL-33 attenuates development and perpetuation of chronic intestinal inflammation. Inflamm Bowel Dis (2012) 18:1900-9. doi:10.1002/ibd.22900
-
(2012)
Inflamm Bowel Dis
, vol.18
, pp. 1900-1909
-
-
Grobeta, P.1
Doser, K.2
Falk, W.3
Obermeier, F.4
Hofmann, C.5
-
194
-
-
84954459145
-
The IL-33/ST2 pathway contributes to intestinal tumorigenesis in humans and mice
-
Mertz KD, Mager LF, Wasmer MH, Thiesler T, Koelzer VH, Ruzzante G, et al. The IL-33/ST2 pathway contributes to intestinal tumorigenesis in humans and mice. Oncoimmunology (2016) 5:e1062966. doi:10.1080/2162402X.2015.1062966
-
(2016)
Oncoimmunology
, vol.5
-
-
Mertz, K.D.1
Mager, L.F.2
Wasmer, M.H.3
Thiesler, T.4
Koelzer, V.H.5
Ruzzante, G.6
-
195
-
-
84922433330
-
Dynamics of the IL-33/ST2 network in the progression of human colorectal adenoma to sporadic colorectal cancer
-
Cui G, Qi H, Gundersen MD, Yang H, Christiansen I, Sorbye SW, et al. Dynamics of the IL-33/ST2 network in the progression of human colorectal adenoma to sporadic colorectal cancer. Cancer Immunol Immunother (2015) 64:181-90. doi:10.1007/s00262-014-1624-x
-
(2015)
Cancer Immunol Immunother
, vol.64
, pp. 181-190
-
-
Cui, G.1
Qi, H.2
Gundersen, M.D.3
Yang, H.4
Christiansen, I.5
Sorbye, S.W.6
-
196
-
-
84929191609
-
IL-33 activates tumor stroma to promote intestinal polyposis
-
Maywald RL, Doerner SK, Pastorelli L, De Salvo C, Benton SM, Dawson EP, et al. IL-33 activates tumor stroma to promote intestinal polyposis. Proc Natl Acad Sci U S A (2015) 112:E2487-96. doi:10.1073/pnas.1422445112
-
(2015)
Proc Natl Acad Sci U S A
, vol.112
, pp. E2487-E2496
-
-
Maywald, R.L.1
Doerner, S.K.2
Pastorelli, L.3
De Salvo, C.4
Benton, S.M.5
Dawson, E.P.6
-
197
-
-
33846101552
-
IL-33, the IL-1-like cytokine ligand for ST2 receptor, is a chromatin-associated nuclear factor in vivo
-
Carriere V, Roussel L, Ortega N, Lacorre DA, Americh L, Aguilar L, et al. IL-33, the IL-1-like cytokine ligand for ST2 receptor, is a chromatin-associated nuclear factor in vivo. Proc Natl Acad Sci U S A (2007) 104:282-7. doi:10.1073/pnas.0606854104
-
(2007)
Proc Natl Acad Sci U S A
, vol.104
, pp. 282-287
-
-
Carriere, V.1
Roussel, L.2
Ortega, N.3
Lacorre, D.A.4
Americh, L.5
Aguilar, L.6
-
198
-
-
84936761972
-
IL-33 signaling contributes to the pathogenesis of myeloproliferative neoplasms
-
Mager LF, Riether C, Schurch CM, Banz Y, Wasmer MH, Stuber R, et al. IL-33 signaling contributes to the pathogenesis of myeloproliferative neoplasms. J Clin Invest (2015) 125:2579-91. doi:10.1172/JCI77347
-
(2015)
J Clin Invest
, vol.125
, pp. 2579-2591
-
-
Mager, L.F.1
Riether, C.2
Schurch, C.M.3
Banz, Y.4
Wasmer, M.H.5
Stuber, R.6
-
199
-
-
84954393953
-
An antitumorigenic role for the IL-33 receptor, ST2L, in colon cancer
-
O'Donnell C, Mahmoud A, Keane J, Murphy C, White D, Carey S, et al. An antitumorigenic role for the IL-33 receptor, ST2L, in colon cancer. Br J Cancer (2016) 114:37-43. doi:10.1038/bjc.2015.433
-
(2016)
Br J Cancer
, vol.114
, pp. 37-43
-
-
O'Donnell, C.1
Mahmoud, A.2
Keane, J.3
Murphy, C.4
White, D.5
Carey, S.6
-
200
-
-
84918555747
-
IL-33/ST2 pathway contributes to metastasis of human colorectal cancer
-
Liu X, Zhu L, Lu X, Bian H, Wu X, Yang W, et al. IL-33/ST2 pathway contributes to metastasis of human colorectal cancer. Biochem Biophys Res Commun (2014) 453:486-92. doi:10.1016/j.bbrc.2014.09.106
-
(2014)
Biochem Biophys Res Commun
, vol.453
, pp. 486-492
-
-
Liu, X.1
Zhu, L.2
Lu, X.3
Bian, H.4
Wu, X.5
Yang, W.6
-
201
-
-
78650199530
-
Inflammatory bowel disease-associated interleukin-33 is preferentially expressed in ulceration-associated myofibroblasts
-
Sponheim J, Pollheimer J, Olsen T, Balogh J, Hammarstrom C, Loos T, et al. Inflammatory bowel disease-associated interleukin-33 is preferentially expressed in ulceration-associated myofibroblasts. Am J Pathol (2010) 177:2804-15. doi:10.2353/ajpath.2010.100378
-
(2010)
Am J Pathol
, vol.177
, pp. 2804-2815
-
-
Sponheim, J.1
Pollheimer, J.2
Olsen, T.3
Balogh, J.4
Hammarstrom, C.5
Loos, T.6
-
202
-
-
84859378165
-
Endogenous IL-33 is highly expressed in mouse epithelial barrier tissues, lymphoid organs, brain, embryos, and inflamed tissues: in situ analysis using a novel Il-33-LacZ gene trap reporter strain
-
Pichery M, Mirey E, Mercier P, Lefrancais E, Dujardin A, Ortega N, et al. Endogenous IL-33 is highly expressed in mouse epithelial barrier tissues, lymphoid organs, brain, embryos, and inflamed tissues: in situ analysis using a novel Il-33-LacZ gene trap reporter strain. J Immunol (2012) 188:3488-95. doi:10.4049/jimmunol.1101977
-
(2012)
J Immunol
, vol.188
, pp. 3488-3495
-
-
Pichery, M.1
Mirey, E.2
Mercier, P.3
Lefrancais, E.4
Dujardin, A.5
Ortega, N.6
-
203
-
-
70449475108
-
Interleukin-33 induces angiogenesis and vascular permeability through ST2/TRAF6-mediated endothelial nitric oxide production
-
Choi YS, Choi HJ, Min JK, Pyun BJ, Maeng YS, Park H, et al. Interleukin-33 induces angiogenesis and vascular permeability through ST2/TRAF6-mediated endothelial nitric oxide production. Blood (2009) 114:3117-26. doi:10.1182/blood-2009-02-203372
-
(2009)
Blood
, vol.114
, pp. 3117-3126
-
-
Choi, Y.S.1
Choi, H.J.2
Min, J.K.3
Pyun, B.J.4
Maeng, Y.S.5
Park, H.6
-
204
-
-
84902109000
-
Interleukin-33 induces urokinase in human endothelial cells-possible impact on angiogenesis
-
Stojkovic S, Kaun C, Heinz M, Krychtiuk KA, Rauscher S, Lemberger CE, et al. Interleukin-33 induces urokinase in human endothelial cells-possible impact on angiogenesis. J Thromb Haemost (2014) 12:948-57. doi:10.1111/jth.12581
-
(2014)
J Thromb Haemost
, vol.12
, pp. 948-957
-
-
Stojkovic, S.1
Kaun, C.2
Heinz, M.3
Krychtiuk, K.A.4
Rauscher, S.5
Lemberger, C.E.6
-
205
-
-
84871960166
-
Immune-dependent and independent antitumor activity of GM-CSF aberrantly expressed by mouse and human colorectal tumors
-
Urdinguio RG, Fernandez AF, Moncada-Pazos A, Huidobro C, Rodriguez RM, Ferrero C, et al. Immune-dependent and independent antitumor activity of GM-CSF aberrantly expressed by mouse and human colorectal tumors. Cancer Res (2013) 73:395-405. doi:10.1158/0008-5472.CAN-12-0806
-
(2013)
Cancer Res
, vol.73
, pp. 395-405
-
-
Urdinguio, R.G.1
Fernandez, A.F.2
Moncada-Pazos, A.3
Huidobro, C.4
Rodriguez, R.M.5
Ferrero, C.6
-
206
-
-
84902687656
-
GM-CSF production by tumor cells is associated with improved survival in colorectal cancer
-
Nebiker CA, Han J, Eppenberger-Castori S, Iezzi G, Hirt C, Amicarella F, et al. GM-CSF production by tumor cells is associated with improved survival in colorectal cancer. Clin Cancer Res (2014) 20:3094-106. doi:10.1158/1078-0432.CCR-13-2774
-
(2014)
Clin Cancer Res
, vol.20
, pp. 3094-3106
-
-
Nebiker, C.A.1
Han, J.2
Eppenberger-Castori, S.3
Iezzi, G.4
Hirt, C.5
Amicarella, F.6
-
207
-
-
84893837713
-
Tumor-derived GM-CSF promotes inflammatory colon carcinogenesis via stimulating epithelial release of VEGF
-
Wang Y, Han G, Wang K, Liu G, Wang R, Xiao H, et al. Tumor-derived GM-CSF promotes inflammatory colon carcinogenesis via stimulating epithelial release of VEGF. Cancer Res (2014) 74:716-26. doi:10.1158/0008-5472.CAN-13-1459
-
(2014)
Cancer Res
, vol.74
, pp. 716-726
-
-
Wang, Y.1
Han, G.2
Wang, K.3
Liu, G.4
Wang, R.5
Xiao, H.6
-
208
-
-
0031808821
-
GM-CSF gene expression and protein production in human colorectal cancer cell lines and clinical tumor specimens
-
Trutmann M, Terracciano L, Noppen C, Kloth J, Kaspar M, Peterli R, et al. GM-CSF gene expression and protein production in human colorectal cancer cell lines and clinical tumor specimens. Int J Cancer (1998) 77:378-85. doi:10.1002/(SICI)1097-0215(19980729)77:3<378::AID-IJC12>3.0.CO;2-4
-
(1998)
Int J Cancer
, vol.77
, pp. 378-385
-
-
Trutmann, M.1
Terracciano, L.2
Noppen, C.3
Kloth, J.4
Kaspar, M.5
Peterli, R.6
-
209
-
-
84960335147
-
ILC3 GM-CSF production and mobilisation orchestrate acute intestinal inflammation
-
Pearson C, Thornton EE, McKenzie B, Schaupp AL, Huskens N, Griseri T, et al. ILC3 GM-CSF production and mobilisation orchestrate acute intestinal inflammation. Elife (2016) 5:e10066. doi:10.7554/eLife.10066
-
(2016)
Elife
, vol.5
-
-
Pearson, C.1
Thornton, E.E.2
McKenzie, B.3
Schaupp, A.L.4
Huskens, N.5
Griseri, T.6
-
210
-
-
77958006456
-
Cellular vaccine approaches
-
Le DT, Pardoll DM, Jaffee EM. Cellular vaccine approaches. Cancer J (2010) 16:304-10. doi:10.1097/PPO.0b013e3181eb33d7
-
(2010)
Cancer J
, vol.16
, pp. 304-310
-
-
Le, D.T.1
Pardoll, D.M.2
Jaffee, E.M.3
-
211
-
-
84937689047
-
Granulocyte macrophage colony-stimulating factor-activated eosinophils promote interleukin-23 driven chronic colitis
-
Griseri T, Arnold IC, Pearson C, Krausgruber T, Schiering C, Franchini F, et al. Granulocyte macrophage colony-stimulating factor-activated eosinophils promote interleukin-23 driven chronic colitis. Immunity (2015) 43:187-99. doi:10.1016/j.immuni.2015.07.008
-
(2015)
Immunity
, vol.43
, pp. 187-199
-
-
Griseri, T.1
Arnold, I.C.2
Pearson, C.3
Krausgruber, T.4
Schiering, C.5
Franchini, F.6
-
212
-
-
0342424368
-
Prognostic influence of tumor-associated eosinophilic infiltrate in colorectal carcinoma
-
Fernandez-Acenero MJ, Galindo-Gallego M, Sanz J, Aljama A. Prognostic influence of tumor-associated eosinophilic infiltrate in colorectal carcinoma. Cancer (2000) 88:1544-8. doi:10.1002/(SICI)1097-0142(20000401)88:7<1544::AID-CNCR7>3.3.CO;2-J
-
(2000)
Cancer
, vol.88
, pp. 1544-1548
-
-
Fernandez-Acenero, M.J.1
Galindo-Gallego, M.2
Sanz, J.3
Aljama, A.4
-
213
-
-
70349336496
-
The granulocyte-macrophage colony-stimulating factor receptor: linking its structure to cell signaling and its role in disease
-
Hercus TR, Thomas D, Guthridge MA, Ekert PG, King-Scott J, Parker MW, et al. The granulocyte-macrophage colony-stimulating factor receptor: linking its structure to cell signaling and its role in disease. Blood (2009) 114:1289-98. doi:10.1182/blood-2008-12-164004
-
(2009)
Blood
, vol.114
, pp. 1289-1298
-
-
Hercus, T.R.1
Thomas, D.2
Guthridge, M.A.3
Ekert, P.G.4
King-Scott, J.5
Parker, M.W.6
-
214
-
-
84908867157
-
Expression and DNA methylation of TNF, IFNG and FOXP3 in colorectal cancer and their prognostic significance
-
Ganapathi SK, Beggs AD, Hodgson SV, Kumar D. Expression and DNA methylation of TNF, IFNG and FOXP3 in colorectal cancer and their prognostic significance. Br J Cancer (2014) 111:1581-9. doi:10.1038/bjc.2014.477
-
(2014)
Br J Cancer
, vol.111
, pp. 1581-1589
-
-
Ganapathi, S.K.1
Beggs, A.D.2
Hodgson, S.V.3
Kumar, D.4
-
215
-
-
33646849272
-
The correlation between colorectal cancer rates of proliferation and apoptosis and systemic cytokine levels; plus their influence upon survival
-
Evans C, Morrison I, Heriot AG, Bartlett JB, Finlayson C, Dalgleish AG, et al. The correlation between colorectal cancer rates of proliferation and apoptosis and systemic cytokine levels; plus their influence upon survival. Br J Cancer (2006) 94:1412-9. doi:10.1038/sj.bjc.6603104
-
(2006)
Br J Cancer
, vol.94
, pp. 1412-1419
-
-
Evans, C.1
Morrison, I.2
Heriot, A.G.3
Bartlett, J.B.4
Finlayson, C.5
Dalgleish, A.G.6
-
216
-
-
84926456534
-
Deficiency of interferon-gamma or its receptor promotes colorectal cancer development
-
Wang L, Wang Y, Song Z, Chu J, Qu X. Deficiency of interferon-gamma or its receptor promotes colorectal cancer development. J Interferon Cytokine Res (2015) 35:273-80. doi:10.1089/jir.2014.0132
-
(2015)
J Interferon Cytokine Res
, vol.35
, pp. 273-280
-
-
Wang, L.1
Wang, Y.2
Song, Z.3
Chu, J.4
Qu, X.5
-
217
-
-
0036839071
-
Most murine CD8+ intestinal intraepithelial lymphocytes are partially but not fully activated T cells
-
Wang HC, Zhou Q, Dragoo J, Klein JR. Most murine CD8+ intestinal intraepithelial lymphocytes are partially but not fully activated T cells. J Immunol (2002) 169:4717-22. doi:10.4049/jimmunol.169.9.4717
-
(2002)
J Immunol
, vol.169
, pp. 4717-4722
-
-
Wang, H.C.1
Zhou, Q.2
Dragoo, J.3
Klein, J.R.4
-
218
-
-
34848908792
-
IFN-gamma-producing dendritic cells are important for priming of gut intraepithelial lymphocyte response against intracellular parasitic infection
-
Moretto MM, Weiss LM, Combe CL, Khan IA. IFN-gamma-producing dendritic cells are important for priming of gut intraepithelial lymphocyte response against intracellular parasitic infection. J Immunol (2007) 179:2485-92. doi:10.4049/jimmunol.179.4.2485
-
(2007)
J Immunol
, vol.179
, pp. 2485-2492
-
-
Moretto, M.M.1
Weiss, L.M.2
Combe, C.L.3
Khan, I.A.4
-
219
-
-
70349675873
-
Production of interferon-gamma by activated T-cell receptor-alphabeta CD8alphabeta intestinal intraepithelial lymphocytes is required and sufficient for disruption of the intestinal barrier integrity
-
Zufferey C, Erhart D, Saurer L, Mueller C. Production of interferon-gamma by activated T-cell receptor-alphabeta CD8alphabeta intestinal intraepithelial lymphocytes is required and sufficient for disruption of the intestinal barrier integrity. Immunology (2009) 128:351-9. doi:10.1111/j.1365-2567.2009.03110.x
-
(2009)
Immunology
, vol.128
, pp. 351-359
-
-
Zufferey, C.1
Erhart, D.2
Saurer, L.3
Mueller, C.4
-
220
-
-
0026661047
-
Distribution of interferon-gamma receptor in human tissues
-
Valente G, Ozmen L, Novelli F, Geuna M, Palestro G, Forni G, et al. Distribution of interferon-gamma receptor in human tissues. Eur J Immunol (1992) 22:2403-12. doi:10.1002/eji.1830220933
-
(1992)
Eur J Immunol
, vol.22
, pp. 2403-2412
-
-
Valente, G.1
Ozmen, L.2
Novelli, F.3
Geuna, M.4
Palestro, G.5
Forni, G.6
-
221
-
-
33750321707
-
Interferons, immunity and cancer immunoediting
-
Dunn GP, Koebel CM, Schreiber RD. Interferons, immunity and cancer immunoediting. Nat Rev Immunol (2006) 6:836-48. doi:10.1038/nri1961
-
(2006)
Nat Rev Immunol
, vol.6
, pp. 836-848
-
-
Dunn, G.P.1
Koebel, C.M.2
Schreiber, R.D.3
-
222
-
-
84880271158
-
Both STAT1 and STAT3 are favourable prognostic determinants in colorectal carcinoma
-
Gordziel C, Bratsch J, Moriggl R, Knosel T, Friedrich K. Both STAT1 and STAT3 are favourable prognostic determinants in colorectal carcinoma. Br J Cancer (2013) 109:138-46. doi:10.1038/bjc.2013.274
-
(2013)
Br J Cancer
, vol.109
, pp. 138-146
-
-
Gordziel, C.1
Bratsch, J.2
Moriggl, R.3
Knosel, T.4
Friedrich, K.5
-
223
-
-
0024553788
-
Interferon-gamma directly affects barrier function of cultured intestinal epithelial monolayers
-
Madara JL, Stafford J. Interferon-gamma directly affects barrier function of cultured intestinal epithelial monolayers. J Clin Invest (1989) 83:724-7. doi:10.1172/JCI113938
-
(1989)
J Clin Invest
, vol.83
, pp. 724-727
-
-
Madara, J.L.1
Stafford, J.2
-
224
-
-
0032977248
-
Interferon-gamma decreases barrier function in T84 cells by reducing ZO-1 levels and disrupting apical actin
-
Youakim A, Ahdieh M. Interferon-gamma decreases barrier function in T84 cells by reducing ZO-1 levels and disrupting apical actin. Am J Physiol (1999) 276:G1279-88
-
(1999)
Am J Physiol
, vol.276
, pp. G1279-G1288
-
-
Youakim, A.1
Ahdieh, M.2
-
225
-
-
27644477373
-
Abrogation of IFN-gamma mediated epithelial barrier disruption by serine protease inhibition
-
Willemsen LE, Hoetjes JP, van Deventer SJ, van Tol EA. Abrogation of IFN-gamma mediated epithelial barrier disruption by serine protease inhibition. Clin Exp Immunol (2005) 142:275-84. doi:10.1111/j.1365-2249.2005.02906.x
-
(2005)
Clin Exp Immunol
, vol.142
, pp. 275-284
-
-
Willemsen, L.E.1
Hoetjes, J.P.2
van Deventer, S.J.3
van Tol, E.A.4
-
226
-
-
0042324629
-
Stress-induced disruption of colonic epithelial barrier: role of interferon-gamma and myosin light chain kinase in mice
-
Ferrier L, Mazelin L, Cenac N, Desreumaux P, Janin A, Emilie D, et al. Stress-induced disruption of colonic epithelial barrier: role of interferon-gamma and myosin light chain kinase in mice. Gastroenterology (2003) 125:795-804. doi:10.1016/S0016-5085(03)01057-6
-
(2003)
Gastroenterology
, vol.125
, pp. 795-804
-
-
Ferrier, L.1
Mazelin, L.2
Cenac, N.3
Desreumaux, P.4
Janin, A.5
Emilie, D.6
-
227
-
-
0033565626
-
Transforming growth factor beta1 suppresses nonmetastatic colon cancer at an early stage of tumorigenesis
-
Engle SJ, Hoying JB, Boivin GP, Ormsby I, Gartside PS, Doetschman T. Transforming growth factor beta1 suppresses nonmetastatic colon cancer at an early stage of tumorigenesis. Cancer Res (1999) 59:3379-86
-
(1999)
Cancer Res
, vol.59
, pp. 3379-3386
-
-
Engle, S.J.1
Hoying, J.B.2
Boivin, G.P.3
Ormsby, I.4
Gartside, P.S.5
Doetschman, T.6
-
228
-
-
3142664714
-
Transforming growth factor beta receptor type II inactivation promotes the establishment and progression of colon cancer
-
Biswas S, Chytil A, Washington K, Romero-Gallo J, Gorska AE, Wirth PS, et al. Transforming growth factor beta receptor type II inactivation promotes the establishment and progression of colon cancer. Cancer Res (2004) 64:4687-92. doi:10.1158/0008-5472.CAN-03-3255
-
(2004)
Cancer Res
, vol.64
, pp. 4687-4692
-
-
Biswas, S.1
Chytil, A.2
Washington, K.3
Romero-Gallo, J.4
Gorska, A.E.5
Wirth, P.S.6
-
229
-
-
84872510974
-
SMAD2, SMAD3 and SMAD4 mutations in colorectal cancer
-
Fleming NI, Jorissen RN, Mouradov D, Christie M, Sakthianandeswaren A, Palmieri M, et al. SMAD2, SMAD3 and SMAD4 mutations in colorectal cancer. Cancer Res (2013) 73:725-35. doi:10.1158/0008-5472.CAN-12-2706
-
(2013)
Cancer Res
, vol.73
, pp. 725-735
-
-
Fleming, N.I.1
Jorissen, R.N.2
Mouradov, D.3
Christie, M.4
Sakthianandeswaren, A.5
Palmieri, M.6
-
230
-
-
0029068965
-
High levels of transforming growth factor beta 1 correlate with disease progression in human colon cancer
-
Friedman E, Gold LI, Klimstra D, Zeng ZS, Winawer S, Cohen A. High levels of transforming growth factor beta 1 correlate with disease progression in human colon cancer. Cancer Epidemiol Biomarkers Prev (1995) 4:549-54
-
(1995)
Cancer Epidemiol Biomarkers Prev
, vol.4
, pp. 549-554
-
-
Friedman, E.1
Gold, L.I.2
Klimstra, D.3
Zeng, Z.S.4
Winawer, S.5
Cohen, A.6
-
231
-
-
0029740157
-
Transforming growth factor beta 1 expression in human colorectal tumours: an independent prognostic marker in a subgroup of poor prognosis patients
-
Robson H, Anderson E, James RD, Schofield PF. Transforming growth factor beta 1 expression in human colorectal tumours: an independent prognostic marker in a subgroup of poor prognosis patients. Br J Cancer (1996) 74:753-8. doi:10.1038/bjc.1996.432
-
(1996)
Br J Cancer
, vol.74
, pp. 753-758
-
-
Robson, H.1
Anderson, E.2
James, R.D.3
Schofield, P.F.4
-
232
-
-
0034896088
-
Circulating transforming growth factor beta 1 as a predictor of liver metastasis after resection in colorectal cancer
-
Tsushima H, Ito N, Tamura S, Matsuda Y, Inada M, Yabuuchi I, et al. Circulating transforming growth factor beta 1 as a predictor of liver metastasis after resection in colorectal cancer. Clin Cancer Res (2001) 7:1258-62
-
(2001)
Clin Cancer Res
, vol.7
, pp. 1258-1262
-
-
Tsushima, H.1
Ito, N.2
Tamura, S.3
Matsuda, Y.4
Inada, M.5
Yabuuchi, I.6
-
233
-
-
0032489508
-
Intestinal tumorigenesis in compound mutant mice of both Dpc4 (Smad4) and Apc genes
-
Takaku K, Oshima M, Miyoshi H, Matsui M, Seldin MF, Taketo MM. Intestinal tumorigenesis in compound mutant mice of both Dpc4 (Smad4) and Apc genes. Cell (1998) 92:645-56. doi:10.1016/S0092-8674(00)81132-0
-
(1998)
Cell
, vol.92
, pp. 645-656
-
-
Takaku, K.1
Oshima, M.2
Miyoshi, H.3
Matsui, M.4
Seldin, M.F.5
Taketo, M.M.6
-
234
-
-
84928151672
-
miR-1269 promotes metastasis and forms a positive feedback loop with TGF-beta
-
Bu P, Wang L, Chen KY, Rakhilin N, Sun J, Closa A, et al. miR-1269 promotes metastasis and forms a positive feedback loop with TGF-beta. Nat Commun (2015) 6:6879. doi:10.1038/ncomms7879
-
(2015)
Nat Commun
, vol.6
, pp. 6879
-
-
Bu, P.1
Wang, L.2
Chen, K.Y.3
Rakhilin, N.4
Sun, J.5
Closa, A.6
-
235
-
-
34547789841
-
TGF-beta signaling alterations and susceptibility to colorectal cancer
-
Xu Y, Pasche B. TGF-beta signaling alterations and susceptibility to colorectal cancer. Hum Mol Genet (2007) 16(Spec No 1):R14-20. doi:10.1093/hmg/ddl486
-
(2007)
Hum Mol Genet
, vol.16
, pp. R14-R20
-
-
Xu, Y.1
Pasche, B.2
-
236
-
-
78249231410
-
Role of transforming growth factor-beta in inflammatory bowel disease and colitis-associated colon cancer
-
Feagins LA. Role of transforming growth factor-beta in inflammatory bowel disease and colitis-associated colon cancer. Inflamm Bowel Dis (2010) 16:1963-8. doi:10.1002/ibd.21281
-
(2010)
Inflamm Bowel Dis
, vol.16
, pp. 1963-1968
-
-
Feagins, L.A.1
-
237
-
-
84891748444
-
Interaction with colon cancer cells hyperactivates TGF-beta signaling in cancer-associated fibroblasts
-
Hawinkels LJ, Paauwe M, Verspaget HW, Wiercinska E, van der Zon JM, van der Ploeg K, et al. Interaction with colon cancer cells hyperactivates TGF-beta signaling in cancer-associated fibroblasts. Oncogene (2014) 33:97-107. doi:10.1038/onc.2012.536
-
(2014)
Oncogene
, vol.33
, pp. 97-107
-
-
Hawinkels, L.J.1
Paauwe, M.2
Verspaget, H.W.3
Wiercinska, E.4
van der Zon, J.M.5
van der Ploeg, K.6
-
238
-
-
0034644472
-
TGFbeta signaling in growth control, cancer, and heritable disorders
-
Massague J, Blain SW, Lo RS. TGFbeta signaling in growth control, cancer, and heritable disorders. Cell (2000) 103:295-309. doi:10.1016/S0092-8674(00)00121-5
-
(2000)
Cell
, vol.103
, pp. 295-309
-
-
Massague, J.1
Blain, S.W.2
Lo, R.S.3
-
239
-
-
67349162130
-
Tumour necrosis factor and cancer
-
Balkwill F. Tumour necrosis factor and cancer. Nat Rev Cancer (2009) 9:361-71. doi:10.1038/nrc2628
-
(2009)
Nat Rev Cancer
, vol.9
, pp. 361-371
-
-
Balkwill, F.1
-
240
-
-
84959166084
-
Increased expression of tumor necrosis factor-alpha is associated with advanced colorectal cancer stages
-
Al Obeed OA, Alkhayal KA, Al Sheikh A, Zubaidi AM, Vaali-Mohammed MA, Boushey R, et al. Increased expression of tumor necrosis factor-alpha is associated with advanced colorectal cancer stages. World J Gastroenterol (2014) 20:18390-6. doi:10.3748/wjg.v20.i48.18390
-
(2014)
World J Gastroenterol
, vol.20
, pp. 18390-18396
-
-
Al Obeed, O.A.1
Alkhayal, K.A.2
Al Sheikh, A.3
Zubaidi, A.M.4
Vaali-Mohammed, M.A.5
Boushey, R.6
-
241
-
-
84912575005
-
Colorectal cancer severity and survival in correlation with tumour necrosis factor-alpha
-
Stanilov N, Miteva L, Dobreva Z, Stanilova S. Colorectal cancer severity and survival in correlation with tumour necrosis factor-alpha. Biotechnol Biotechnol Equip (2014) 28:911-7. doi:10.1080/13102818.2014.965047
-
(2014)
Biotechnol Biotechnol Equip
, vol.28
, pp. 911-917
-
-
Stanilov, N.1
Miteva, L.2
Dobreva, Z.3
Stanilova, S.4
-
242
-
-
30944442404
-
Infliximab and newly diagnosed neoplasia in Crohn's disease: a multicentre matched pair study
-
Biancone L, Orlando A, Kohn A, Colombo E, Sostegni R, Angelucci E, et al. Infliximab and newly diagnosed neoplasia in Crohn's disease: a multicentre matched pair study. Gut (2006) 55:228-33. doi:10.1136/gut.2005.075937
-
(2006)
Gut
, vol.55
, pp. 228-233
-
-
Biancone, L.1
Orlando, A.2
Kohn, A.3
Colombo, E.4
Sostegni, R.5
Angelucci, E.6
-
243
-
-
72549112691
-
Long-term safety of Infliximab for the treatment of inflammatory bowel disease: does blocking TNFalpha reduce colitis-associated colorectal carcinogenesis?
-
Biancone L, Petruzziello C, Calabrese E, Zorzi F, Naccarato P, Onali S, et al. Long-term safety of Infliximab for the treatment of inflammatory bowel disease: does blocking TNFalpha reduce colitis-associated colorectal carcinogenesis? Gut (2009) 58:1703. doi:10.1136/gut.2008.176461
-
(2009)
Gut
, vol.58
, pp. 1703
-
-
Biancone, L.1
Petruzziello, C.2
Calabrese, E.3
Zorzi, F.4
Naccarato, P.5
Onali, S.6
-
244
-
-
63849251824
-
Long-term safety of infliximab for the treatment of inflammatory bowel disease: a single-centre cohort study
-
Fidder H, Schnitzler F, Ferrante M, Noman M, Katsanos K, Segaert S, et al. Long-term safety of infliximab for the treatment of inflammatory bowel disease: a single-centre cohort study. Gut (2009) 58:501-8. doi:10.1136/gut.2008.163642
-
(2009)
Gut
, vol.58
, pp. 501-508
-
-
Fidder, H.1
Schnitzler, F.2
Ferrante, M.3
Noman, M.4
Katsanos, K.5
Segaert, S.6
-
245
-
-
84896117860
-
In vivo imaging using fluorescent antibodies to tumor necrosis factor predicts therapeutic response in Crohn's disease
-
Atreya R, Neumann H, Neufert C, Waldner MJ, Billmeier U, Zopf Y, et al. In vivo imaging using fluorescent antibodies to tumor necrosis factor predicts therapeutic response in Crohn's disease. Nat Med (2014) 20:313-8. doi:10.1038/nm.3462
-
(2014)
Nat Med
, vol.20
, pp. 313-318
-
-
Atreya, R.1
Neumann, H.2
Neufert, C.3
Waldner, M.J.4
Billmeier, U.5
Zopf, Y.6
-
246
-
-
84879401216
-
Expression of RORgammat marks a pathogenic regulatory T cell subset in human colon cancer
-
Blatner NR, Mulcahy MF, Dennis KL, Scholtens D, Bentrem DJ, Phillips JD, et al. Expression of RORgammat marks a pathogenic regulatory T cell subset in human colon cancer. Sci Transl Med (2012) 4:164ra159. doi:10.1126/scitranslmed.3004566
-
(2012)
Sci Transl Med
, vol.4
-
-
Blatner, N.R.1
Mulcahy, M.F.2
Dennis, K.L.3
Scholtens, D.4
Bentrem, D.J.5
Phillips, J.D.6
-
247
-
-
38849171267
-
Blocking TNF-alpha in mice reduces colorectal carcinogenesis associated with chronic colitis
-
Popivanova BK, Kitamura K, Wu Y, Kondo T, Kagaya T, Kaneko S, et al. Blocking TNF-alpha in mice reduces colorectal carcinogenesis associated with chronic colitis. J Clin Invest (2008) 118:560-70. doi:10.1172/JCI32453
-
(2008)
J Clin Invest
, vol.118
, pp. 560-570
-
-
Popivanova, B.K.1
Kitamura, K.2
Wu, Y.3
Kondo, T.4
Kagaya, T.5
Kaneko, S.6
-
248
-
-
84865527211
-
Obesity-induced increase in tumor necrosis factor-alpha leads to development of colon cancer in mice
-
Flores MB, Rocha GZ, Damas-Souza DM, Osorio-Costa F, Dias MM, Ropelle ER, et al. Obesity-induced increase in tumor necrosis factor-alpha leads to development of colon cancer in mice. Gastroenterology (2012) 143(741-753):e741-4. doi:10.1053/j.gastro.2012.05.045
-
(2012)
Gastroenterology
, vol.143
, Issue.741-753
, pp. e741-e744
-
-
Flores, M.B.1
Rocha, G.Z.2
Damas-Souza, D.M.3
Osorio-Costa, F.4
Dias, M.M.5
Ropelle, E.R.6
-
249
-
-
0026442689
-
Tumor necrosis factor-alpha-dependent production of reactive nitrogen intermediates mediates IFN-gamma plus IL-2-induced murine macrophage tumoricidal activity
-
Cox GW, Melillo G, Chattopadhyay U, Mullet D, Fertel RH, Varesio L. Tumor necrosis factor-alpha-dependent production of reactive nitrogen intermediates mediates IFN-gamma plus IL-2-induced murine macrophage tumoricidal activity. J Immunol (1992) 149:3290-6
-
(1992)
J Immunol
, vol.149
, pp. 3290-3296
-
-
Cox, G.W.1
Melillo, G.2
Chattopadhyay, U.3
Mullet, D.4
Fertel, R.H.5
Varesio, L.6
-
250
-
-
33847029227
-
Colon cancer cell-derived tumor necrosis factor-alpha mediates the tumor growth-promoting response in macrophages by up-regulating the colony-stimulating factor-1 pathway
-
Zins K, Abraham D, Sioud M, Aharinejad S. Colon cancer cell-derived tumor necrosis factor-alpha mediates the tumor growth-promoting response in macrophages by up-regulating the colony-stimulating factor-1 pathway. Cancer Res (2007) 67:1038-45. doi:10.1158/0008-5472.CAN-06-2295
-
(2007)
Cancer Res
, vol.67
, pp. 1038-1045
-
-
Zins, K.1
Abraham, D.2
Sioud, M.3
Aharinejad, S.4
-
251
-
-
84883410561
-
Protective role of tumor necrosis factor (TNF) receptors in chronic intestinal inflammation: TNFR1 ablation boosts systemic inflammatory response
-
Wang Y, Han G, Chen Y, Wang K, Liu G, Wang R, et al. Protective role of tumor necrosis factor (TNF) receptors in chronic intestinal inflammation: TNFR1 ablation boosts systemic inflammatory response. Lab Invest (2013) 93:1024-35. doi:10.1038/labinvest.2013.89
-
(2013)
Lab Invest
, vol.93
, pp. 1024-1035
-
-
Wang, Y.1
Han, G.2
Chen, Y.3
Wang, K.4
Liu, G.5
Wang, R.6
-
252
-
-
0036142256
-
Role of tumor necrosis factor receptor 2 (TNFR2) in colonic epithelial hyperplasia and chronic intestinal inflammation in mice
-
Mizoguchi E, Mizoguchi A, Takedatsu H, Cario E, de Jong YP, Ooi CJ, et al. Role of tumor necrosis factor receptor 2 (TNFR2) in colonic epithelial hyperplasia and chronic intestinal inflammation in mice. Gastroenterology (2002) 122:134-44. doi:10.1053/gast.2002.30347
-
(2002)
Gastroenterology
, vol.122
, pp. 134-144
-
-
Mizoguchi, E.1
Mizoguchi, A.2
Takedatsu, H.3
Cario, E.4
de Jong, Y.P.5
Ooi, C.J.6
-
253
-
-
84055207486
-
Cytokine induction of tumor necrosis factor receptor 2 is mediated by STAT3 in colon cancer cells
-
Hamilton KE, Simmons JG, Ding S, Van Landeghem L, Lund PK. Cytokine induction of tumor necrosis factor receptor 2 is mediated by STAT3 in colon cancer cells. Mol Cancer Res (2011) 9:1718-31. doi:10.1158/1541-7786.MCR-10-0210
-
(2011)
Mol Cancer Res
, vol.9
, pp. 1718-1731
-
-
Hamilton, K.E.1
Simmons, J.G.2
Ding, S.3
Van Landeghem, L.4
Lund, P.K.5
-
254
-
-
84868629269
-
TNF signaling drives myeloid-derived suppressor cell accumulation
-
Zhao X, Rong L, Zhao X, Li X, Liu X, Deng J, et al. TNF signaling drives myeloid-derived suppressor cell accumulation. J Clin Invest (2012) 122:4094-104. doi:10.1172/JCI64115
-
(2012)
J Clin Invest
, vol.122
, pp. 4094-4104
-
-
Zhao, X.1
Rong, L.2
Zhao, X.3
Li, X.4
Liu, X.5
Deng, J.6
-
255
-
-
84929875491
-
Regulation of tumour necrosis factor signalling: live or let die
-
Brenner D, Blaser H, Mak TW. Regulation of tumour necrosis factor signalling: live or let die. Nat Rev Immunol (2015) 15:362-74. doi:10.1038/nri3834
-
(2015)
Nat Rev Immunol
, vol.15
, pp. 362-374
-
-
Brenner, D.1
Blaser, H.2
Mak, T.W.3
-
256
-
-
84864414700
-
A novel murine model of inflammatory bowel disease and inflammation-associated colon cancer with ulcerative colitis-like features
-
Hale LP, Greer PK. A novel murine model of inflammatory bowel disease and inflammation-associated colon cancer with ulcerative colitis-like features. PLoS One (2012) 7:e41797. doi:10.1371/journal.pone.0041797
-
(2012)
PLoS One
, vol.7
-
-
Hale, L.P.1
Greer, P.K.2
-
257
-
-
73249130655
-
Expression of HIF-1alpha and VEGF in colorectal cancer: association with clinical outcomes and prognostic implications
-
Cao D, Hou M, Guan YS, Jiang M, Yang Y, Gou HF. Expression of HIF-1alpha and VEGF in colorectal cancer: association with clinical outcomes and prognostic implications. BMC Cancer (2009) 9:432. doi:10.1186/1471-2407-9-432
-
(2009)
BMC Cancer
, vol.9
, pp. 432
-
-
Cao, D.1
Hou, M.2
Guan, Y.S.3
Jiang, M.4
Yang, Y.5
Gou, H.F.6
-
258
-
-
58149150071
-
VEGF-1 expression in colorectal cancer is associated with disease localization, stage, and long-term disease-specific survival
-
Bendardaf R, Buhmeida A, Hilska M, Laato M, Syrjanen S, Syrjanen K, et al. VEGF-1 expression in colorectal cancer is associated with disease localization, stage, and long-term disease-specific survival. Anticancer Res (2008) 28:3865-70
-
(2008)
Anticancer Res
, vol.28
, pp. 3865-3870
-
-
Bendardaf, R.1
Buhmeida, A.2
Hilska, M.3
Laato, M.4
Syrjanen, S.5
Syrjanen, K.6
-
259
-
-
18244387773
-
Danish RANX05 Colorectal Cancer Study Group. Prognostic impact of matched preoperative plasma and serum VEGF in patients with primary colorectal carcinoma
-
Werther K, Christensen IJ, Nielsen HJ, Danish RANX05 Colorectal Cancer Study Group. Prognostic impact of matched preoperative plasma and serum VEGF in patients with primary colorectal carcinoma. Br J Cancer (2002) 86:417-23. doi:10.1038/sj.bjc.6600075
-
(2002)
Br J Cancer
, vol.86
, pp. 417-423
-
-
Werther, K.1
Christensen, I.J.2
Nielsen, H.J.3
-
260
-
-
78650407055
-
VEGF receptor signaling links inflammation and tumorigenesis in colitis-associated cancer
-
Waldner MJ, Wirtz S, Jefremow A, Warntjen M, Neufert C, Atreya R, et al. VEGF receptor signaling links inflammation and tumorigenesis in colitis-associated cancer. J Exp Med (2010) 207:2855-68. doi:10.1084/jem.20100438
-
(2010)
J Exp Med
, vol.207
, pp. 2855-2868
-
-
Waldner, M.J.1
Wirtz, S.2
Jefremow, A.3
Warntjen, M.4
Neufert, C.5
Atreya, R.6
-
261
-
-
34547519439
-
Inhibition of VEGF-A prevents the angiogenic switch and results in increased survival of Apc+/min mice
-
Korsisaari N, Kasman IM, Forrest WF, Pal N, Bai W, Fuh G, et al. Inhibition of VEGF-A prevents the angiogenic switch and results in increased survival of Apc+/min mice. Proc Natl Acad Sci U S A (2007) 104:10625-30. doi:10.1073/pnas.0704213104
-
(2007)
Proc Natl Acad Sci U S A
, vol.104
, pp. 10625-10630
-
-
Korsisaari, N.1
Kasman, I.M.2
Forrest, W.F.3
Pal, N.4
Bai, W.5
Fuh, G.6
-
262
-
-
33749549907
-
Inhibiting vascular endothelial growth factor receptor-2 signaling reduces tumor burden in the ApcMin/+ mouse model of early intestinal cancer
-
Goodlad RA, Ryan AJ, Wedge SR, Pyrah IT, Alferez D, Poulsom R, et al. Inhibiting vascular endothelial growth factor receptor-2 signaling reduces tumor burden in the ApcMin/+ mouse model of early intestinal cancer. Carcinogenesis (2006) 27:2133-9. doi:10.1093/carcin/bgl113
-
(2006)
Carcinogenesis
, vol.27
, pp. 2133-2139
-
-
Goodlad, R.A.1
Ryan, A.J.2
Wedge, S.R.3
Pyrah, I.T.4
Alferez, D.5
Poulsom, R.6
-
263
-
-
66149086950
-
Positive and negative modulation of angiogenesis by VEGFR1 ligands
-
Cao Y. Positive and negative modulation of angiogenesis by VEGFR1 ligands. Sci Signal (2009) 2:re1. doi:10.1126/scisignal.259re1
-
(2009)
Sci Signal
, vol.2
-
-
Cao, Y.1
-
264
-
-
0037531794
-
The angiogenic switch for vascular endothelial growth factor (VEGF)-A, VEGF-B, VEGF-C, and VEGF-D in the adenoma-carcinoma sequence during colorectal cancer progression
-
Hanrahan V, Currie MJ, Gunningham SP, Morrin HR, Scott PA, Robinson BA, et al. The angiogenic switch for vascular endothelial growth factor (VEGF)-A, VEGF-B, VEGF-C, and VEGF-D in the adenoma-carcinoma sequence during colorectal cancer progression. J Pathol (2003) 200:183-94. doi:10.1002/path.1339
-
(2003)
J Pathol
, vol.200
, pp. 183-194
-
-
Hanrahan, V.1
Currie, M.J.2
Gunningham, S.P.3
Morrin, H.R.4
Scott, P.A.5
Robinson, B.A.6
-
265
-
-
73349124764
-
Vascular endothelial growth factor receptor-1 is synthetic lethal to aberrant beta-catenin activation in colon cancer
-
Naik S, Dothager RS, Marasa J, Lewis CL, Piwnica-Worms D. Vascular endothelial growth factor receptor-1 is synthetic lethal to aberrant beta-catenin activation in colon cancer. Clin Cancer Res (2009) 15:7529-37. doi:10.1158/1078-0432.CCR-09-0336
-
(2009)
Clin Cancer Res
, vol.15
, pp. 7529-7537
-
-
Naik, S.1
Dothager, R.S.2
Marasa, J.3
Lewis, C.L.4
Piwnica-Worms, D.5
-
266
-
-
0038745735
-
Beta-catenin regulates vascular endothelial growth factor expression in colon cancer
-
Easwaran V, Lee SH, Inge L, Guo L, Goldbeck C, Garrett E, et al. Beta-catenin regulates vascular endothelial growth factor expression in colon cancer. Cancer Res (2003) 63:3145-53
-
(2003)
Cancer Res
, vol.63
, pp. 3145-3153
-
-
Easwaran, V.1
Lee, S.H.2
Inge, L.3
Guo, L.4
Goldbeck, C.5
Garrett, E.6
-
267
-
-
33845337061
-
Tumour-associated angiogenesis in human colorectal cancer
-
Rmali KA, Puntis MC, Jiang WG. Tumour-associated angiogenesis in human colorectal cancer. Colorectal Dis (2007) 9:3-14. doi:10.1111/j.1463-1318.2006.01089.x
-
(2007)
Colorectal Dis
, vol.9
, pp. 3-14
-
-
Rmali, K.A.1
Puntis, M.C.2
Jiang, W.G.3
-
268
-
-
84946571753
-
The consensus molecular subtypes of colorectal cancer
-
Guinney J, Dienstmann R, Wang X, de Reynies A, Schlicker A, Soneson C, et al. The consensus molecular subtypes of colorectal cancer. Nat Med (2015) 21:1350-6. doi:10.1038/nm.3967
-
(2015)
Nat Med
, vol.21
, pp. 1350-1356
-
-
Guinney, J.1
Dienstmann, R.2
Wang, X.3
de Reynies, A.4
Schlicker, A.5
Soneson, C.6
-
269
-
-
85056746732
-
Inflammatory response in serrated precursor lesions of the colon classified according to WHO entities, clinical parameters and phenotype-genotype correlation
-
Rau TT, Atreya R, Aust D, Baretton G, Eck M, Erlenbach-Wünsch K, et al. Inflammatory response in serrated precursor lesions of the colon classified according to WHO entities, clinical parameters and phenotype-genotype correlation. J Pathol Clin Res (2016). doi:10.1002/cjp2.41
-
(2016)
J Pathol Clin Res
-
-
Rau, T.T.1
Atreya, R.2
Aust, D.3
Baretton, G.4
Eck, M.5
Erlenbach-Wünsch, K.6
-
270
-
-
84872370561
-
Loss of p53 in enterocytes generates an inflammatory microenvironment enabling invasion and lymph node metastasis of carcinogen-induced colorectal tumors
-
Schwitalla S, Ziegler PK, Horst D, Becker V, Kerle I, Begus-Nahrmann Y, et al. Loss of p53 in enterocytes generates an inflammatory microenvironment enabling invasion and lymph node metastasis of carcinogen-induced colorectal tumors. Cancer Cell (2013) 23:93-106. doi:10.1016/j.ccr.2012.11.014
-
(2013)
Cancer Cell
, vol.23
, pp. 93-106
-
-
Schwitalla, S.1
Ziegler, P.K.2
Horst, D.3
Becker, V.4
Kerle, I.5
Begus-Nahrmann, Y.6
-
271
-
-
84897561550
-
IL-6R/STAT3/miR-34a feedback loop promotes EMT-mediated colorectal cancer invasion and metastasis
-
Rokavec M, Oner MG, Li H, Jackstadt R, Jiang L, Lodygin D, et al. IL-6R/STAT3/miR-34a feedback loop promotes EMT-mediated colorectal cancer invasion and metastasis. J Clin Invest (2014) 124:1853-67. doi:10.1172/JCI73531
-
(2014)
J Clin Invest
, vol.124
, pp. 1853-1867
-
-
Rokavec, M.1
Oner, M.G.2
Li, H.3
Jackstadt, R.4
Jiang, L.5
Lodygin, D.6
-
272
-
-
84877823153
-
Mutant p53 prolongs NF-kappaB activation and promotes chronic inflammation and inflammation-associated colorectal cancer
-
Cooks T, Pateras IS, Tarcic O, Solomon H, Schetter AJ, Wilder S, et al. Mutant p53 prolongs NF-kappaB activation and promotes chronic inflammation and inflammation-associated colorectal cancer. Cancer Cell (2013) 23:634-46. doi:10.1016/j.ccr.2013.03.022
-
(2013)
Cancer Cell
, vol.23
, pp. 634-646
-
-
Cooks, T.1
Pateras, I.S.2
Tarcic, O.3
Solomon, H.4
Schetter, A.J.5
Wilder, S.6
-
273
-
-
84867103263
-
Chronic intestinal inflammation: inflammatory bowel disease and colitis-associated colon cancer
-
Rubin DC, Shaker A, Levin MS. Chronic intestinal inflammation: inflammatory bowel disease and colitis-associated colon cancer. Front Immunol (2012) 3:107. doi:10.3389/fimmu.2012.00107
-
(2012)
Front Immunol
, vol.3
, pp. 107
-
-
Rubin, D.C.1
Shaker, A.2
Levin, M.S.3
-
274
-
-
84888227624
-
Myeloid-derived suppressor cells in the inflammatory bowel diseases
-
Ostanin DV, Bhattacharya D. Myeloid-derived suppressor cells in the inflammatory bowel diseases. Inflamm Bowel Dis (2013) 19:2468-77. doi:10.1097/MIB.0b013e3182902b11
-
(2013)
Inflamm Bowel Dis
, vol.19
, pp. 2468-2477
-
-
Ostanin, D.V.1
Bhattacharya, D.2
-
275
-
-
51249105349
-
Myeloid-derived suppressor cells in inflammatory bowel disease: a new immunoregulatory pathway
-
Haile LA, von Wasielewski R, Gamrekelashvili J, Kruger C, Bachmann O, Westendorf AM, et al. Myeloid-derived suppressor cells in inflammatory bowel disease: a new immunoregulatory pathway. Gastroenterology (2008) 135:e871-5. doi:10.1053/j.gastro.2008.06.032
-
(2008)
Gastroenterology
, vol.135
, pp. e871-e875
-
-
Haile, L.A.1
von Wasielewski, R.2
Gamrekelashvili, J.3
Kruger, C.4
Bachmann, O.5
Westendorf, A.M.6
-
276
-
-
65249138393
-
Myeloid-derived suppressor cells: linking inflammation and cancer
-
Ostrand-Rosenberg S, Sinha P. Myeloid-derived suppressor cells: linking inflammation and cancer. J Immunol (2009) 182:4499-506. doi:10.4049/jimmunol.0802740
-
(2009)
J Immunol
, vol.182
, pp. 4499-4506
-
-
Ostrand-Rosenberg, S.1
Sinha, P.2
-
277
-
-
0026689558
-
The origin and function of tumor-associated macrophages
-
Mantovani A, Bottazzi B, Colotta F, Sozzani S, Ruco L. The origin and function of tumor-associated macrophages. Immunol Today (1992) 13:265-70. doi:10.1016/0167-5699(92)90008-U
-
(1992)
Immunol Today
, vol.13
, pp. 265-270
-
-
Mantovani, A.1
Bottazzi, B.2
Colotta, F.3
Sozzani, S.4
Ruco, L.5
-
278
-
-
67650151005
-
Cancer-related inflammation, the seventh hallmark of cancer: links to genetic instability
-
Colotta F, Allavena P, Sica A, Garlanda C, Mantovani A. Cancer-related inflammation, the seventh hallmark of cancer: links to genetic instability. Carcinogenesis (2009) 30:1073-81. doi:10.1093/carcin/bgp127
-
(2009)
Carcinogenesis
, vol.30
, pp. 1073-1081
-
-
Colotta, F.1
Allavena, P.2
Sica, A.3
Garlanda, C.4
Mantovani, A.5
-
279
-
-
77950950894
-
Macrophage diversity enhances tumor progression and metastasis
-
Qian BZ, Pollard JW. Macrophage diversity enhances tumor progression and metastasis. Cell (2010) 141:39-51. doi:10.1016/j.cell.2010.03.014
-
(2010)
Cell
, vol.141
, pp. 39-51
-
-
Qian, B.Z.1
Pollard, J.W.2
-
280
-
-
53549102755
-
The tumor microenvironment and its role in promoting tumor growth
-
Whiteside TL. The tumor microenvironment and its role in promoting tumor growth. Oncogene (2008) 27:5904-12. doi:10.1038/onc.2008.271
-
(2008)
Oncogene
, vol.27
, pp. 5904-5912
-
-
Whiteside, T.L.1
-
281
-
-
77950346282
-
Immunity, inflammation, and cancer
-
Grivennikov SI, Greten FR, Karin M. Immunity, inflammation, and cancer. Cell (2010) 140:883-99. doi:10.1016/j.cell.2010.01.025
-
(2010)
Cell
, vol.140
, pp. 883-899
-
-
Grivennikov, S.I.1
Greten, F.R.2
Karin, M.3
-
282
-
-
0004753309
-
Phase II trial of intravenous endotoxin in patients with colorectal and non-small cell lung cancer
-
Otto F, Schmid P, Mackensen A, Wehr U, Seiz A, Braun M, et al. Phase II trial of intravenous endotoxin in patients with colorectal and non-small cell lung cancer. Eur J Cancer (1996) 32A:1712-8. doi:10.1016/0959-8049(96)00186-4
-
(1996)
Eur J Cancer
, vol.32A
, pp. 1712-1718
-
-
Otto, F.1
Schmid, P.2
Mackensen, A.3
Wehr, U.4
Seiz, A.5
Braun, M.6
-
283
-
-
84928062583
-
Immune checkpoint blockade: a common denominator approach to cancer therapy
-
Topalian SL, Drake CG, Pardoll DM. Immune checkpoint blockade: a common denominator approach to cancer therapy. Cancer Cell (2015) 27:450-61. doi:10.1016/j.ccell.2015.03.001
-
(2015)
Cancer Cell
, vol.27
, pp. 450-461
-
-
Topalian, S.L.1
Drake, C.G.2
Pardoll, D.M.3
-
284
-
-
58349090027
-
Potentiating endogenous antitumor immunity to prostate cancer through combination immunotherapy with CTLA4 blockade and GM-CSF
-
Fong L, Kwek SS, O'Brien S, Kavanagh B, McNeel DG, Weinberg V, et al. Potentiating endogenous antitumor immunity to prostate cancer through combination immunotherapy with CTLA4 blockade and GM-CSF. Cancer Res (2009) 69:609-15. doi:10.1158/0008-5472.CAN-08-3529
-
(2009)
Cancer Res
, vol.69
, pp. 609-615
-
-
Fong, L.1
Kwek, S.S.2
O'Brien, S.3
Kavanagh, B.4
McNeel, D.G.5
Weinberg, V.6
-
285
-
-
84898973055
-
Survival, durable tumor remission, and long-term safety in patients with advanced melanoma receiving nivolumab
-
Topalian SL, Sznol M, McDermott DF, Kluger HM, Carvajal RD, Sharfman WH, et al. Survival, durable tumor remission, and long-term safety in patients with advanced melanoma receiving nivolumab. J Clin Oncol (2014) 32:1020-30. doi:10.1200/JCO.2013.53.0105
-
(2014)
J Clin Oncol
, vol.32
, pp. 1020-1030
-
-
Topalian, S.L.1
Sznol, M.2
McDermott, D.F.3
Kluger, H.M.4
Carvajal, R.D.5
Sharfman, W.H.6
-
286
-
-
84942824207
-
An immunogenomic stratification of colorectal cancer: implications for development of targeted immunotherapy
-
Lal N, Beggs AD, Willcox BE, Middleton GW. An immunogenomic stratification of colorectal cancer: implications for development of targeted immunotherapy. Oncoimmunology (2015) 4:e976052. doi:10.4161/2162402X.2014.976052
-
(2015)
Oncoimmunology
, vol.4
-
-
Lal, N.1
Beggs, A.D.2
Willcox, B.E.3
Middleton, G.W.4
-
287
-
-
84922369377
-
The vigorous immune microenvironment of microsatellite instable colon cancer is balanced by multiple counter-inhibitory checkpoints
-
Llosa NJ, Cruise M, Tam A, Wicks EC, Hechenbleikner EM, Taube JM, et al. The vigorous immune microenvironment of microsatellite instable colon cancer is balanced by multiple counter-inhibitory checkpoints. Cancer Discov (2015) 5:43-51. doi:10.1158/2159-8290.CD-14-0863
-
(2015)
Cancer Discov
, vol.5
, pp. 43-51
-
-
Llosa, N.J.1
Cruise, M.2
Tam, A.3
Wicks, E.C.4
Hechenbleikner, E.M.5
Taube, J.M.6
-
288
-
-
77955292303
-
Phase II study of the anti-cytotoxic T-lymphocyte-associated antigen 4 monoclonal antibody, tremelimumab, in patients with refractory metastatic colorectal cancer
-
Chung KY, Gore I, Fong L, Venook A, Beck SB, Dorazio P, et al. Phase II study of the anti-cytotoxic T-lymphocyte-associated antigen 4 monoclonal antibody, tremelimumab, in patients with refractory metastatic colorectal cancer. J Clin Oncol (2010) 28:3485-90. doi:10.1200/JCO.2010.28.3994
-
(2010)
J Clin Oncol
, vol.28
, pp. 3485-3490
-
-
Chung, K.Y.1
Gore, I.2
Fong, L.3
Venook, A.4
Beck, S.B.5
Dorazio, P.6
-
289
-
-
84862903106
-
Safety and activity of anti-PD-L1 antibody in patients with advanced cancer
-
Brahmer JR, Tykodi SS, Chow LQ, Hwu WJ, Topalian SL, Hwu P, et al. Safety and activity of anti-PD-L1 antibody in patients with advanced cancer. N Engl J Med (2012) 366:2455-65. doi:10.1056/NEJMoa1200694
-
(2012)
N Engl J Med
, vol.366
, pp. 2455-2465
-
-
Brahmer, J.R.1
Tykodi, S.S.2
Chow, L.Q.3
Hwu, W.J.4
Topalian, S.L.5
Hwu, P.6
-
290
-
-
79551521053
-
Phase III trial assessing bevacizumab in stages II and III carcinoma of the colon: results of NSABP protocol C-08
-
Allegra CJ, Yothers G, O'Connell MJ, Sharif S, Petrelli NJ, Colangelo LH, et al. Phase III trial assessing bevacizumab in stages II and III carcinoma of the colon: results of NSABP protocol C-08. J Clin Oncol (2011) 29:11-6. doi:10.1200/JCO.2010.30.0855
-
(2011)
J Clin Oncol
, vol.29
, pp. 11-16
-
-
Allegra, C.J.1
Yothers, G.2
O'Connell, M.J.3
Sharif, S.4
Petrelli, N.J.5
Colangelo, L.H.6
-
291
-
-
84908139591
-
Initial therapy with FOLFOXIRI and bevacizumab for metastatic colorectal cancer
-
Loupakis F, Cremolini C, Masi G, Lonardi S, Zagonel V, Salvatore L, et al. Initial therapy with FOLFOXIRI and bevacizumab for metastatic colorectal cancer. N Engl J Med (2014) 371:1609-18. doi:10.1056/NEJMoa1403108
-
(2014)
N Engl J Med
, vol.371
, pp. 1609-1618
-
-
Loupakis, F.1
Cremolini, C.2
Masi, G.3
Lonardi, S.4
Zagonel, V.5
Salvatore, L.6
-
292
-
-
34548732637
-
A placebo-controlled double blind trial of etanercept for the cancer anorexia/weight loss syndrome: results from N00C1 from the North Central Cancer Treatment Group
-
Jatoi A, Dakhil SR, Nguyen PL, Sloan JA, Kugler JW, Rowland KM Jr, et al. A placebo-controlled double blind trial of etanercept for the cancer anorexia/weight loss syndrome: results from N00C1 from the North Central Cancer Treatment Group. Cancer (2007) 110:1396-403. doi:10.1002/cncr.22944
-
(2007)
Cancer
, vol.110
, pp. 1396-1403
-
-
Jatoi, A.1
Dakhil, S.R.2
Nguyen, P.L.3
Sloan, J.A.4
Kugler, J.W.5
Rowland, K.M.6
-
293
-
-
84898967209
-
A phase I/II, multiple-dose, dose-escalation study of siltuximab, an anti-interleukin-6 monoclonal antibody, in patients with advanced solid tumors
-
Angevin E, Tabernero J, Elez E, Cohen SJ, Bahleda R, van Laethem JL, et al. A phase I/II, multiple-dose, dose-escalation study of siltuximab, an anti-interleukin-6 monoclonal antibody, in patients with advanced solid tumors. Clin Cancer Res (2014) 20:2192-204. doi:10.1158/1078-0432.CCR-13-2200
-
(2014)
Clin Cancer Res
, vol.20
, pp. 2192-2204
-
-
Angevin, E.1
Tabernero, J.2
Elez, E.3
Cohen, S.J.4
Bahleda, R.5
van Laethem, J.L.6
-
294
-
-
78449244037
-
The emerging toxicity profiles of anti-CTLA-4 antibodies across clinical indications
-
Di Giacomo AM, Biagioli M, Maio M. The emerging toxicity profiles of anti-CTLA-4 antibodies across clinical indications. Semin Oncol (2010) 37:499-507. doi:10.1053/j.seminoncol.2010.09.007
-
(2010)
Semin Oncol
, vol.37
, pp. 499-507
-
-
Di Giacomo, A.M.1
Biagioli, M.2
Maio, M.3
-
295
-
-
84862859820
-
Safety, activity, and immune correlates of anti-PD-1 antibody in cancer
-
Topalian SL, Hodi FS, Brahmer JR, Gettinger SN, Smith DC, McDermott DF, et al. Safety, activity, and immune correlates of anti-PD-1 antibody in cancer. N Engl J Med (2012) 366:2443-54. doi:10.1056/NEJMoa1200690
-
(2012)
N Engl J Med
, vol.366
, pp. 2443-2454
-
-
Topalian, S.L.1
Hodi, F.S.2
Brahmer, J.R.3
Gettinger, S.N.4
Smith, D.C.5
McDermott, D.F.6
-
296
-
-
84924690678
-
Gut microbiome development along the colorectal adenoma-carcinoma sequence
-
Feng Q, Liang S, Jia H, Stadlmayr A, Tang L, Lan Z, et al. Gut microbiome development along the colorectal adenoma-carcinoma sequence. Nat Commun (2015) 6:6528. doi:10.1038/ncomms7528
-
(2015)
Nat Commun
, vol.6
, pp. 6528
-
-
Feng, Q.1
Liang, S.2
Jia, H.3
Stadlmayr, A.4
Tang, L.5
Lan, Z.6
-
297
-
-
84926436561
-
Microbiota disbiosis is associated with colorectal cancer
-
Gao Z, Guo B, Gao R, Zhu Q, Qin H. Microbiota disbiosis is associated with colorectal cancer. Front Microbiol (2015) 6:20. doi:10.3389/fmicb.2015.00020
-
(2015)
Front Microbiol
, vol.6
, pp. 20
-
-
Gao, Z.1
Guo, B.2
Gao, R.3
Zhu, Q.4
Qin, H.5
-
298
-
-
70350343544
-
Induction of intestinal Th17 cells by segmented filamentous bacteria
-
Ivanov II, Atarashi K, Manel N, Brodie EL, Shima T, Karaoz U, et al. Induction of intestinal Th17 cells by segmented filamentous bacteria. Cell (2009) 139:485-98. doi:10.1016/j.cell.2009.09.033
-
(2009)
Cell
, vol.139
, pp. 485-498
-
-
Ivanov, I.I.1
Atarashi, K.2
Manel, N.3
Brodie, E.L.4
Shima, T.5
Karaoz, U.6
-
299
-
-
85027947787
-
Induction of colonic regulatory T cells by indigenous Clostridium species
-
Atarashi K, Tanoue T, Shima T, Imaoka A, Kuwahara T, Momose Y, et al. Induction of colonic regulatory T cells by indigenous Clostridium species. Science (2011) 331:337-41. doi:10.1126/science.1198469
-
(2011)
Science
, vol.331
, pp. 337-341
-
-
Atarashi, K.1
Tanoue, T.2
Shima, T.3
Imaoka, A.4
Kuwahara, T.5
Momose, Y.6
-
300
-
-
0002647979
-
Non-pathogenic bacteria elicit a differential cytokine response by intestinal epithelial cell/leucocyte co-cultures
-
Haller D, Bode C, Hammes WP, Pfeifer AM, Schiffrin EJ, Blum S. Non-pathogenic bacteria elicit a differential cytokine response by intestinal epithelial cell/leucocyte co-cultures. Gut (2000) 47:79-87. doi:10.1136/gut.47.1.79
-
(2000)
Gut
, vol.47
, pp. 79-87
-
-
Haller, D.1
Bode, C.2
Hammes, W.P.3
Pfeifer, A.M.4
Schiffrin, E.J.5
Blum, S.6
-
301
-
-
78650166351
-
Induction of cytokine formation by human intestinal bacteria in gut epithelial cell lines
-
Bahrami B, Macfarlane S, Macfarlane GT. Induction of cytokine formation by human intestinal bacteria in gut epithelial cell lines. J Appl Microbiol (2011) 110:353-63. doi:10.1111/j.1365-2672.2010.04889.x
-
(2011)
J Appl Microbiol
, vol.110
, pp. 353-363
-
-
Bahrami, B.1
Macfarlane, S.2
Macfarlane, G.T.3
-
302
-
-
84892476369
-
Alterations in the microbiota drive interleukin-17C production from intestinal epithelial cells to promote tumorigenesis
-
Song X, Gao H, Lin Y, Yao Y, Zhu S, Wang J, et al. Alterations in the microbiota drive interleukin-17C production from intestinal epithelial cells to promote tumorigenesis. Immunity (2014) 40:140-52. doi:10.1016/j.immuni.2013.11.018
-
(2014)
Immunity
, vol.40
, pp. 140-152
-
-
Song, X.1
Gao, H.2
Lin, Y.3
Yao, Y.4
Zhu, S.5
Wang, J.6
-
303
-
-
84919884555
-
Microbiota organization is a distinct feature of proximal colorectal cancers
-
Dejea CM, Wick EC, Hechenbleikner EM, White JR, Mark Welch JL, Rossetti BJ, et al. Microbiota organization is a distinct feature of proximal colorectal cancers. Proc Natl Acad Sci U S A (2014) 111:18321-6. doi:10.1073/pnas.1406199111
-
(2014)
Proc Natl Acad Sci U S A
, vol.111
, pp. 18321-18326
-
-
Dejea, C.M.1
Wick, E.C.2
Hechenbleikner, E.M.3
White, J.R.4
Mark Welch, J.L.5
Rossetti, B.J.6
-
304
-
-
84892449521
-
Activation of Gpr109a, receptor for niacin and the commensal metabolite butyrate, suppresses colonic inflammation and carcinogenesis
-
Singh N, Gurav A, Sivaprakasam S, Brady E, Padia R, Shi H, et al. Activation of Gpr109a, receptor for niacin and the commensal metabolite butyrate, suppresses colonic inflammation and carcinogenesis. Immunity (2014) 40:128-39. doi:10.1016/j.immuni.2013.12.007
-
(2014)
Immunity
, vol.40
, pp. 128-139
-
-
Singh, N.1
Gurav, A.2
Sivaprakasam, S.3
Brady, E.4
Padia, R.5
Shi, H.6
-
305
-
-
84948451779
-
Commensal Bifidobacterium promotes antitumor immunity and facilitates anti-PD-L1 efficacy
-
Sivan A, Corrales L, Hubert N, Williams JB, Aquino-Michaels K, Earley ZM, et al. Commensal Bifidobacterium promotes antitumor immunity and facilitates anti-PD-L1 efficacy. Science (2015) 350:1084-9. doi:10.1126/science.aac4255
-
(2015)
Science
, vol.350
, pp. 1084-1089
-
-
Sivan, A.1
Corrales, L.2
Hubert, N.3
Williams, J.B.4
Aquino-Michaels, K.5
Earley, Z.M.6
-
306
-
-
84948461699
-
Anticancer immunotherapy by CTLA-4 blockade relies on the gut microbiota
-
Vetizou M, Pitt JM, Daillere R, Lepage P, Waldschmitt N, Flament C, et al. Anticancer immunotherapy by CTLA-4 blockade relies on the gut microbiota. Science (2015) 350:1079-84. doi:10.1126/science.aad1329
-
(2015)
Science
, vol.350
, pp. 1079-1084
-
-
Vetizou, M.1
Pitt, J.M.2
Daillere, R.3
Lepage, P.4
Waldschmitt, N.5
Flament, C.6
|