miR-1269 promotes metastasis and forms a positive feedback loop with TGF-β

Nature Communications

Volumn 6, Issue , 2015, Pages

  Bu, Pengcheng ^a   Wang, Lihua ^b   Chen, Kai Yuan ^a   Rakhilin, Nikolai ^a   Sun, Jian ^c   Closa, Adria ^d,e   Tung, Kuei Ling ^b   King, Sarah ^b   Varanko, Anastasia Kristine ^b   Xu, Yitian ^b   Chen, Joyce Huan ^a   Zessin, Amelia S ^f   Shealy, James ^a   Cummings, Bethany ^g   Hsu, David ^f   Lipkin, Steven M ^c   Moreno, Victor ^d,e   Gümüş, Zeynep H ^h   Shen, Xiling ^a,b  

^a Cornell University   (United States)

^b Department of Biological and Environmental Engineering   (United States)

^c WEILL CORNELL MEDICAL COLLEGE   (United States)

^d UNIVERSITY OF BARCELONA   (Spain)

^e CATALAN INSTITUTE OF ONCOLOGY   (Spain)

^f DUKE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^g Department of Obstetrics Gynecology   (United States)

^h MOUNT SINAI SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

MICRORNA; MICRORNA 1269; MICRORNA 1269A; SMAD7 PROTEIN; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR HOXD10; TRANSFORMING GROWTH FACTOR BETA; UNCLASSIFIED DRUG; HOMEODOMAIN PROTEIN; HOXD10 PROTEIN, HUMAN; MIRN1269 MICRORNA, HUMAN; SMAD7 PROTEIN, HUMAN; SOX4 PROTEIN, HUMAN; TRANSCRIPTION FACTOR SOX;

CANCER; GENE EXPRESSION; GENETIC MARKER; GERM CELL; SIGNALING; SURVIVORSHIP;

ADJUVANT CHEMOTHERAPY; AGED; ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CANCER GROWTH; CANCER RECURRENCE; CANCER RISK; CANCER STAGING; CANCER SURGERY; CLINICAL OBSERVATION; CONTROLLED STUDY; DISEASE FREE SURVIVAL; FEMALE; HCT116 CELL LINE; HUMAN; HUMAN CELL; IN VIVO STUDY; MAJOR CLINICAL STUDY; MALE; METASTATIC COLORECTAL CANCER; MOUSE; NONHUMAN; POSITIVE FEEDBACK; PRIMARY TUMOR; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; UPREGULATION; ADULT; ANIMAL; CANCER TRANSPLANTATION; CELL MOTION; CELL PROLIFERATION; CHROMATIN IMMUNOPRECIPITATION; COLORECTAL TUMOR; FEEDBACK SYSTEM; FLUORESCENT ANTIBODY TECHNIQUE; GENETICS; HCT 116 CELL LINE; HT-29 CELL LINE; METABOLISM; METASTASIS; MIDDLE AGED; PATHOLOGY; PROGNOSIS; REAL TIME POLYMERASE CHAIN REACTION; TUMOR CELL LINE; TUMOR RECURRENCE; VERY ELDERLY; WESTERN BLOTTING; YOUNG ADULT;

ADULT; AGED; AGED, 80 AND OVER; ANIMALS; BLOTTING, WESTERN; CELL LINE, TUMOR; CELL MOVEMENT; CELL PROLIFERATION; CHROMATIN IMMUNOPRECIPITATION; COLORECTAL NEOPLASMS; FEEDBACK, PHYSIOLOGICAL; FEMALE; FLUORESCENT ANTIBODY TECHNIQUE; HCT116 CELLS; HOMEODOMAIN PROTEINS; HT29 CELLS; HUMANS; MALE; MICE; MICRORNAS; MIDDLE AGED; NEOPLASM METASTASIS; NEOPLASM RECURRENCE, LOCAL; NEOPLASM STAGING; NEOPLASM TRANSPLANTATION; PROGNOSIS; REAL-TIME POLYMERASE CHAIN REACTION; SMAD7 PROTEIN; SOXC TRANSCRIPTION FACTORS; TRANSCRIPTION FACTORS; TRANSFORMING GROWTH FACTOR BETA; YOUNG ADULT;

EID: 84928151672     PISSN: None     EISSN: 20411723     Source Type: Journal    
DOI: 10.1038/ncomms7879     Document Type: Article

References (24)

1. Yokota, J. Tumor progression and metastasis. Carcinogenesis 21, 497-503 (2000).
2. Quail, D. F. & Joyce, J. A. Microenvironmental regulation of tumor progression and metastasis. Nature Med. 19, 1423-1437 (2013).
3. Siegel, R. et al. Cancer treatment and survivorship statistics, 2012. CA Cancer J. Clin. 62, 220-241 (2012).
4. Siegel, R., Naishadham, D. & Jemal, A. Cancer statistics, 2012. CA Cancer J. Clin. 62, 10-29 (2012).
5. Fearon, E. R. & Vogelstein, B. A genetic model for colorectal tumorigenesis. Cell 61, 759-767 (1990).
6. Valastyan, S. & Weinberg, R. A. Tumor metastasis: molecular insights and evolving paradigms. Cell 147, 275-292 (2011).
7. Benson, 3rd A. B. et al. American Society of Clinical Oncology recommendations on adjuvant chemotherapy for stage II colon cancer. J. Clin. Oncol. 22, 3408-3419 (2004).
8. Chun, P. & Wainberg, Z. A. Adjuvant chemotherapy for stage II colon cancer: the role of molecular markers in choosing therapy. Gastrointest. Cancer Res. 3, 191-196 (2009).
9. Croce, C. M. Causes and consequences of microRNA dysregulation in cancer. Nat. Rev. Genet. 10, 704-714 (2009).
10. Kasinski, A. L. & Slack, F. J. Epigenetics and genetics. MicroRNAs en route to the clinic: progress in validating and targeting microRNAs for cancer therapy. Nat. Rev. Cancer 11, 849-864 (2011).
11. Valeri, N. et al. MicroRNA-135b promotes cancer progression by acting as a downstream effector of oncogenic pathways in colon cancer. Cancer Cell 25, 469-483 (2014).
12. The Cancer Genome Atlas Network. Comprehensive molecular characterization of human colon and rectal cancer. Nature 487, 330-337 (2012).
13. Colonomics.org http://bioinfo.iconcologia.net/colonomics/ (2014).
14. Leibovitz, A. et al. Classification of human colorectal adenocarcinoma cell lines. Cancer Res. 36, 4562-4569 (1976).
15. Fu, X. Y., Besterman, J. M., Monosov, A. & Hoffman, R. M. Models of human metastatic colon cancer in nude mice orthotopically constructed by using histologically intact patient specimens. Proc. Natl Acad. Sci. USA 88, 9345-9349 (1991).
16. Cespedes, M. V. et al. Orthotopic microinjection of human colon cancer cells in nude mice induces tumor foci in all clinically relevant metastatic sites. Am. J. Pathol. 170, 1077-1085 (2007).
17. Brabletz, T. et al. Invasion and metastasis in colorectal cancer: epithelial-mesenchymal transition, mesenchymal-epithelial transition, stem cells and beta-catenin. Cells Tissues Organs 179, 56-65 (2005).
18. Kuwahara, M. et al. The transcription factor Sox4 is a downstream target of signaling by the cytokine TGF-beta and suppresses T(H)2 differentiation. Nat. Immunol. 13, 778-786 (2012).
19. Tiwari, N. et al. Sox4 is a master regulator of epithelial-mesenchymal transition by controlling Ezh2 expression and epigenetic reprogramming. Cancer Cell 23, 768-783 (2013).
20. Ma, L., Teruya-Feldstein, J. & Weinberg, R. A. Tumour invasion and metastasis initiated by microRNA-10b in breast cancer. Nature 449, 682-688 (2007).
21. Yan, X., Liu, Z. & Chen, Y. Regulation of TGF-beta signaling by Smad7. Acta Biochim. Biophys. Sin. (Shanghai) 41, 263-272 (2009).
22. Hamfjord, J. et al. Differential expression of miRNAs in colorectal cancer: comparison of paired tumor tissue and adjacent normal mucosa using highthroughput sequencing. PLoS One 7, e34150 (2012).
23. Ebert, M. S. & Sharp, P. A. Roles for microRNAs in conferring robustness to biological processes. Cell 149, 515-524 (2012).
24. Calon, A. et al. Dependency of colorectal cancer on a TGF-beta-driven program in stromal cells for metastasis initiation. Cancer Cell 22, 571-584 (2012).