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Volumn 173, Issue 2, 2004, Pages 900-909

IL-21 enhances and sustains CD8+ T cell responses to achieve durable tumor immunity: Comparative evaluation of IL-2, IL-15, and IL-21

Author keywords

[No Author keywords available]

Indexed keywords

CD8 ANTIGEN; INTERLEUKIN 15; INTERLEUKIN 2; INTERLEUKIN 21;

EID: 2542595794     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.173.2.900     Document Type: Article
Times cited : (241)

References (48)
  • 1
    • 0032485487 scopus 로고    scopus 로고
    • Dendritic cells acquire antigen from apoptotic cells and induce class I-restricted CTLs
    • Albert, M. L., B. Sauter, and N. Bhardwaj. 1998. Dendritic cells acquire antigen from apoptotic cells and induce class I-restricted CTLs. Nature 392:86.
    • (1998) Nature , vol.392 , pp. 86
    • Albert, M.L.1    Sauter, B.2    Bhardwaj, N.3
  • 3
    • 17744418516 scopus 로고    scopus 로고
    • CD40-CD40 ligand interactions and their role in cytotoxic T lymphocyte priming and anti-tumor immunity
    • Toes, R. E., S. P. Schoenberger, E. I. van der Voort, R. Offringa, and C. J. Melief. 1998. CD40-CD40 ligand interactions and their role in cytotoxic T lymphocyte priming and anti-tumor immunity. Semin. Immunol. 10:443.
    • (1998) Semin. Immunol. , vol.10 , pp. 443
    • Toes, R.E.1    Schoenberger, S.P.2    Van Der Voort, E.I.3    Offringa, R.4    Melief, C.J.5
  • 5
    • 0037124329 scopus 로고    scopus 로고
    • Multiple choices: Regulation of memory CD8 T cell generation and homeostasis by interleukin (IL)-7 and IL-15
    • Prlic, M., L. Lefrancois, and S. C. Jameson. 2002. Multiple choices: regulation of memory CD8 T cell generation and homeostasis by interleukin (IL)-7 and IL-15. J. Exp. Med. 195:F49.
    • (2002) J. Exp. Med. , vol.195
    • Prlic, M.1    Lefrancois, L.2    Jameson, S.C.3
  • 7
    • 0019230961 scopus 로고
    • T-T cell interactions during cytotoxic T lymphocyte (CTL) responses: T cell derived helper factor (interleukin 2) as a probe to analyze CTL responsiveness and thymic maturation of CTL progenitors
    • Wagner, H., C. Hardt, K. Heeg, K. Pfizenmaier, W. Solbach, R. Bartlett, H. Stockinger, and M. Rollinghoff. 1980. T-T cell interactions during cytotoxic T lymphocyte (CTL) responses: T cell derived helper factor (interleukin 2) as a probe to analyze CTL responsiveness and thymic maturation of CTL progenitors. Immunol. Rev. 51:215.
    • (1980) Immunol. Rev. , vol.51 , pp. 215
    • Wagner, H.1    Hardt, C.2    Heeg, K.3    Pfizenmaier, K.4    Solbach, W.5    Bartlett, R.6    Stockinger, H.7    Rollinghoff, M.8
  • 8
    • 0035102242 scopus 로고    scopus 로고
    • Contrasting roles of IL-2 and IL-I5 in the life and death of lymphocytes: Implications for immunotherapy
    • Waldmann, T. A., S. Dubois, and Y. Tagaya. 2001. Contrasting roles of IL-2 and IL-I5 in the life and death of lymphocytes: implications for immunotherapy. Immunity 14:105.
    • (2001) Immunity , vol.14 , pp. 105
    • Waldmann, T.A.1    Dubois, S.2    Tagaya, Y.3
  • 9
    • 0038655228 scopus 로고    scopus 로고
    • Cytokine control of memory T-cell development and survival
    • Schluns, K. S., and L. Lefrancois. 2003. Cytokine control of memory T-cell development and survival. Nat. Rev. Immunol. 3:269.
    • (2003) Nat. Rev. Immunol. , vol.3 , pp. 269
    • Schluns, K.S.1    Lefrancois, L.2
  • 10
    • 0037103249 scopus 로고    scopus 로고
    • Opposing effects of IL-2 in tumor immunotherapy: Promoting CD8 T cell growth and inducing apoptosis
    • Shrikant, P., and M. F. Mescher. 2002. Opposing effects of IL-2 in tumor immunotherapy: promoting CD8 T cell growth and inducing apoptosis. J. Immunol. 169:1753.
    • (2002) J. Immunol. , vol.169 , pp. 1753
    • Shrikant, P.1    Mescher, M.F.2
  • 11
    • 0034332403 scopus 로고    scopus 로고
    • Interleukin-7 mediates the homeostasis of naive and memory CD8 T cells in vivo
    • Schluns, K. S., W. C. Kieper, S. C. Jameson, and L. Lefrancois. 2000. Interleukin-7 mediates the homeostasis of naive and memory CD8 T cells in vivo. Nat. Immunol. 1:426.
    • (2000) Nat. Immunol. , vol.1 , pp. 426
    • Schluns, K.S.1    Kieper, W.C.2    Jameson, S.C.3    Lefrancois, L.4
  • 13
    • 0028962572 scopus 로고
    • The role of shared receptor motifs and common Stat proteins in the generation of cytokine pleiotropy and redundancy by IL-2, IL-4, IL-7, IL-13, and IL-15
    • Lin, J. X., T. S. Migone, M., Tsang, M. Friedmann, J. A. Weatherbee, L. Zhou, A. Yamauchi, E. T. Bloom, J. Mietz, S. John, et al. 1995. The role of shared receptor motifs and common Stat proteins in the generation of cytokine pleiotropy and redundancy by IL-2, IL-4, IL-7, IL-13, and IL-15. Immunity 2:331.
    • (1995) Immunity , vol.2 , pp. 331
    • Lin, J.X.1    Migone, T.S.2    Tsang, M.3    Friedmann, M.4    Weatherbee, J.A.5    Zhou, L.6    Yamauchi, A.7    Bloom, E.T.8    Mietz, J.9    John, S.10
  • 14
    • 0036467459 scopus 로고    scopus 로고
    • Activation-induced nonresponsiveness: A Th-dependent regulatory checkpoint in the CTL response
    • Tham, E. L., P. Shrikant, and M. F. Mescher. 2002. Activation-induced nonresponsiveness: a Th-dependent regulatory checkpoint in the CTL response. J. Immunol. 168:1190.
    • (2002) J. Immunol. , vol.168 , pp. 1190
    • Tham, E.L.1    Shrikant, P.2    Mescher, M.F.3
  • 15
    • 0036672918 scopus 로고    scopus 로고
    • Maintaining the norm: T-cell homeostasis
    • Jameson, S. C. 2002. Maintaining the norm: T-cell homeostasis. Nat Rev. Immunol. 2:547.
    • (2002) Nat. Rev. Immunol. , vol.2 , pp. 547
    • Jameson, S.C.1
  • 17
    • 0033082369 scopus 로고    scopus 로고
    • Multiple γ c-dependent cytokines regulate T-cell development
    • Malek, T. R., B. O. Porter, and Y. W. He. 1999. Multiple γ c-dependent cytokines regulate T-cell development. Immunol. Today 20:71.
    • (1999) Immunol. Today , vol.20 , pp. 71
    • Malek, T.R.1    Porter, B.O.2    He, Y.W.3
  • 18
    • 0026017971 scopus 로고
    • Interleukin-2 programs mouse αβ T lymphocytes for apoptosis
    • Lenardo, M. J. 1991. Interleukin-2 programs mouse αβ T lymphocytes for apoptosis. Nature 353:858.
    • (1991) Nature , vol.353 , pp. 858
    • Lenardo, M.J.1
  • 23
    • 0032211699 scopus 로고    scopus 로고
    • IL-15 receptor maintains lymphoid homeostasis by supporting lymphocyte homing and proliferation
    • Lodolce, J. P., D. L. Boone, S. Chai, R. E. Swain, T. Dassopoulos, S. Trettin, and A. Ma. 1998. IL-15 receptor maintains lymphoid homeostasis by supporting lymphocyte homing and proliferation. Immunity 9:669.
    • (1998) Immunity , vol.9 , pp. 669
    • Lodolce, J.P.1    Boone, D.L.2    Chai, S.3    Swain, R.E.4    Dassopoulos, T.5    Trettin, S.6    Ma, A.7
  • 24
    • 10744230081 scopus 로고    scopus 로고
    • Interleukin (IL)-21 and IL-15 genetic transfer synergistically augments therapeutic antitumor immunity and promotes regression of metastatic lymphoma
    • Kishida, T., H. Asada, Y. Itokawa, F. D. Cui, M. Shin-Ya, S. Gojo, K. Yasutomi, Y. Ueda, H. Yamagishi, J. Imanishi, et al. 2003. Interleukin (IL)-21 and IL-15 genetic transfer synergistically augments therapeutic antitumor immunity and promotes regression of metastatic lymphoma. Mol. Ther. 8:552.
    • (2003) Mol. Ther. , vol.8 , pp. 552
    • Kishida, T.1    Asada, H.2    Itokawa, Y.3    Cui, F.D.4    Shin-Ya, M.5    Gojo, S.6    Yasutomi, K.7    Ueda, Y.8    Yamagishi, H.9    Imanishi, J.10
  • 25
    • 0033104693 scopus 로고    scopus 로고
    • + T cells: Efficacy is limited by migration away from the site and induction of nonresponsiveness
    • + T cells: efficacy is limited by migration away from the site and induction of nonresponsiveness. J. Immunol. 162:2858.
    • (1999) J. Immunol. , vol.162 , pp. 2858
    • Shrikant, P.1    Mescher, M.F.2
  • 27
    • 0035902080 scopus 로고    scopus 로고
    • Progress in human tumour immunology and immunotherapy
    • Rosenberg, S. A. 2001. Progress in human tumour immunology and immunotherapy. Nature 411:380.
    • (2001) Nature , vol.411 , pp. 380
    • Rosenberg, S.A.1
  • 29
    • 0036852893 scopus 로고    scopus 로고
    • Interleukin-21 and the IL-21 receptor: Novel effectors of NK and T cell responses
    • Parrish-Novak, J., D. C. Foster, R. D. Holly, and C. H. Clegg. 2002. Interleukin-21 and the IL-21 receptor: novel effectors of NK and T cell responses. J. Leukocyte Biol. 72:856.
    • (2002) J. Leukocyte Biol. , vol.72 , pp. 856
    • Parrish-Novak, J.1    Foster, D.C.2    Holly, R.D.3    Clegg, C.H.4
  • 30
    • 18344394955 scopus 로고    scopus 로고
    • IL-21 limits NK cell responses and promotes antigen-specific T cell activation: A mediator of the transition from innate to adaptive immunity
    • Kasaian, M. T., M. J. Whitters, L. L. Carter, L. D. Lowe, J. M. Jussif, B. Deng, K. A. Johnson, J. S. Witek, M. Senices, R. F. Konz, et al. 2002. IL-21 limits NK cell responses and promotes antigen-specific T cell activation: a mediator of the transition from innate to adaptive immunity. Immunity 16:559.
    • (2002) Immunity , vol.16 , pp. 559
    • Kasaian, M.T.1    Whitters, M.J.2    Carter, L.L.3    Lowe, L.D.4    Jussif, J.M.5    Deng, B.6    Johnson, K.A.7    Witek, J.S.8    Senices, M.9    Konz, R.F.10
  • 31
    • 0038784488 scopus 로고    scopus 로고
    • IL-21 activates both innate and adaptive immunity to generate potent antitumor responses that require perforin but are independent of IFN-γ
    • Ma, H. L., M. J. Whitters, R. F. Konz, M. Senices, D. A. Young, M. J. Grusby, M. Collins, and K. Dunussi-Joannopoulos. 2003. IL-21 activates both innate and adaptive immunity to generate potent antitumor responses that require perforin but are independent of IFN-γ. J. Immunol. 171:608.
    • (2003) J. Immunol. , vol.171 , pp. 608
    • Ma, H.L.1    Whitters, M.J.2    Konz, R.F.3    Senices, M.4    Young, D.A.5    Grusby, M.J.6    Collins, M.7    Dunussi-Joannopoulos, K.8
  • 32
    • 0036784616 scopus 로고    scopus 로고
    • IL-21 up-regulates the expression of genes associated with innate immunity and Th1 response
    • Strengell, M., T. Sareneva, D. Foster, I. Julkunen, and S. Matikainen. 2002. IL-21 up-regulates the expression of genes associated with innate immunity and Th1 response. J. Immunol. 169:3600.
    • (2002) J. Immunol. , vol.169 , pp. 3600
    • Strengell, M.1    Sareneva, T.2    Foster, D.3    Julkunen, I.4    Matikainen, S.5
  • 34
    • 0023821578 scopus 로고
    • Introduction of soluble protein into the class I pathway of antigen processing and presentation
    • Moore, M. W., F. R. Carbone, and M. J. Bevan. 1988. Introduction of soluble protein into the class I pathway of antigen processing and presentation. Cell 54:777.
    • (1988) Cell , vol.54 , pp. 777
    • Moore, M.W.1    Carbone, F.R.2    Bevan, M.J.3
  • 35
    • 0037220792 scopus 로고    scopus 로고
    • In vivo augmentation of tumor-specific CTL responses by class I/peptide antigen complexes on microspheres (large multivalent immunogen)
    • Goldberg, J., P. Shrikant, and M. F. Mescher. 2003. In vivo augmentation of tumor-specific CTL responses by class I/peptide antigen complexes on microspheres (large multivalent immunogen). J. Immunol. 170:228.
    • (2003) J. Immunol. , vol.170 , pp. 228
    • Goldberg, J.1    Shrikant, P.2    Mescher, M.F.3
  • 37
    • 0035337444 scopus 로고    scopus 로고
    • The role of adoptively transferred CD8 T cells and host cells in the control of the growth of the EG7 thymoma: Factors that determine the relative effectiveness and homing properties of Tc1 and Tc2 effectors
    • Helmich, B. K., and R. W. Dutton. 2001. The role of adoptively transferred CD8 T cells and host cells in the control of the growth of the EG7 thymoma: factors that determine the relative effectiveness and homing properties of Tc1 and Tc2 effectors. J. Immunol. 166:6500.
    • (2001) J. Immunol. , vol.166 , pp. 6500
    • Helmich, B.K.1    Dutton, R.W.2
  • 41
    • 0037037544 scopus 로고    scopus 로고
    • Interleukin 21 is a T helper (Th) cell 2 cytokine that specifically inhibits the differentiation of naive Th cells into interferon γ-producing Th1 cells
    • Wurster, A. L., V. L. Rodgers, A. R. Satoskar, M. J. Whitters, D. A. Young, M. Collins, and M. J. Grusby. 2002. Interleukin 21 is a T helper (Th) cell 2 cytokine that specifically inhibits the differentiation of naive Th cells into interferon γ-producing Th1 cells. J. Exp. Med. 196:969.
    • (2002) J. Exp. Med. , vol.196 , pp. 969
    • Wurster, A.L.1    Rodgers, V.L.2    Satoskar, A.R.3    Whitters, M.J.4    Young, D.A.5    Collins, M.6    Grusby, M.J.7
  • 43
    • 0037112367 scopus 로고    scopus 로고
    • Constitutive activation of Stat3 in human prostate tumors and cell lines: Direct inhibition of Stat3 signaling induces apoptosis of prostate cancer cells
    • Mora, L. B., R. Buettner, J. Seigne, J. Diaz, N. Ahmad, R. Garcia, T. Bowman, R. Falcone, R. Fairclough, A. Cantor, et al. 2002. Constitutive activation of Stat3 in human prostate tumors and cell lines: direct inhibition of Stat3 signaling induces apoptosis of prostate cancer cells. Cancer Res. 62:6659.
    • (2002) Cancer Res. , vol.62 , pp. 6659
    • Mora, L.B.1    Buettner, R.2    Seigne, J.3    Diaz, J.4    Ahmad, N.5    Garcia, R.6    Bowman, T.7    Falcone, R.8    Fairclough, R.9    Cantor, A.10
  • 44
    • 0036919939 scopus 로고    scopus 로고
    • Differentiation of human γ-δ T cells towards distinct memory phenotypes
    • Eberl, M., R. Engel, E. Beck, and H. Jomaa. 2002. Differentiation of human γ-δ T cells towards distinct memory phenotypes. Cell. Immunol. 218:1.
    • (2002) Cell. Immunol. , vol.218 , pp. 1
    • Eberl, M.1    Engel, R.2    Beck, E.3    Jomaa, H.4
  • 45
    • 0036568946 scopus 로고    scopus 로고
    • On CD28/CD40 ligand costimulation, common γ-chain signals, and the alloimmune response
    • Demirci, G., W. Gao, X. X. Zheng, T. R. Malek, T. B. Strom, and X. C. Li. 2002. On CD28/CD40 ligand costimulation, common γ-chain signals, and the alloimmune response. J. Immunol. 168:4382.
    • (2002) J. Immunol. , vol.168 , pp. 4382
    • Demirci, G.1    Gao, W.2    Zheng, X.X.3    Malek, T.R.4    Strom, T.B.5    Li, X.C.6
  • 46
    • 0037347311 scopus 로고    scopus 로고
    • Expression of the interleukin-21 gene in murine colon carcinoma cells generates systemic immunity in the inoculated hosts
    • Ugai, S., O. Shimozato, K. Kawamura, Y. Q. Wang, T. Yamaguchi, H. Saisho, S. Sakiyama, and M. Tagawa. 2003. Expression of the interleukin-21 gene in murine colon carcinoma cells generates systemic immunity in the inoculated hosts. Cancer Gene Ther. 10:187.
    • (2003) Cancer Gene Ther. , vol.10 , pp. 187
    • Ugai, S.1    Shimozato, O.2    Kawamura, K.3    Wang, Y.Q.4    Yamaguchi, T.5    Saisho, H.6    Sakiyama, S.7    Tagawa, M.8
  • 47
    • 0037716818 scopus 로고    scopus 로고
    • Natural killer cell receptor signaling
    • Lanier, L. L. 2003. Natural killer cell receptor signaling. Curr. Opin. Immunol. 15:308.
    • (2003) Curr. Opin. Immunol. , vol.15 , pp. 308
    • Lanier, L.L.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.