-
1
-
-
0022499547
-
Complementary DNA for a novel human interleukin (BSF-2) that induces B lymphocytes to produce immunoglobulin
-
Hirano T, Yasukawa K, Harada H, Taga T, Watanabe Y, Matsuda T, et al. Complementary DNA for a novel human interleukin (BSF-2) that induces B lymphocytes to produce immunoglobulin. Nature. 1986; 324: 73-76.
-
(1986)
Nature
, vol.324
, pp. 73-76
-
-
Hirano, T.1
Yasukawa, K.2
Harada, H.3
Taga, T.4
Watanabe, Y.5
Matsuda, T.6
-
2
-
-
0025102756
-
Haemopoietic receptors and helical cytokines
-
Bazan JF. Haemopoietic receptors and helical cytokines. Immunol Today. 1990; 11: 350-354.
-
(1990)
Immunol Today
, vol.11
, pp. 350-354
-
-
Bazan, J.F.1
-
3
-
-
0023685762
-
Cloning and expression of the human interleukin-6 (BSF-2/IFN beta 2) receptor
-
Yamasaki K, Taga T, Hirata Y, Yawata H, Kawanishi Y, Seed B, et al. Cloning and expression of the human interleukin-6 (BSF-2/IFN beta 2) receptor. Science. 1988; 241: 825-828.
-
(1988)
Science
, vol.241
, pp. 825-828
-
-
Yamasaki, K.1
Taga, T.2
Hirata, Y.3
Yawata, H.4
Kawanishi, Y.5
Seed, B.6
-
4
-
-
0025630163
-
Molecular cloning and expression of an IL-6 signal transducer, gp130
-
Hibi M, Murakami M, Saito M, Hirano T, Taga T, Kishimoto T. Molecular cloning and expression of an IL-6 signal transducer, gp130. Cell. 1990; 63: 1149-1157.
-
(1990)
Cell
, vol.63
, pp. 1149-1157
-
-
Hibi, M.1
Murakami, M.2
Saito, M.3
Hirano, T.4
Taga, T.5
Kishimoto, T.6
-
5
-
-
0041677606
-
Principles of interleukin (IL)-6-type cytokine signalling and its regulation
-
Heinrich PC, Behrmann I, Haan S, Hermanns HM, Muller-Newen G, Schaper F. Principles of interleukin (IL)-6-type cytokine signalling and its regulation. Biochem J. 2003; 374: 1-20.
-
(2003)
Biochem J
, vol.374
, pp. 1-20
-
-
Heinrich, P.C.1
Behrmann, I.2
Haan, S.3
Hermanns, H.M.4
Muller-Newen, G.5
Schaper, F.6
-
7
-
-
0346157324
-
Acquiring signalling specificity from the cytokine receptor gp130
-
Ernst M, Jenkins BJ. Acquiring signalling specificity from the cytokine receptor gp130. Trends Genet. 2004; 20: 23-32.
-
(2004)
Trends Genet
, vol.20
, pp. 23-32
-
-
Ernst, M.1
Jenkins, B.J.2
-
8
-
-
59849091830
-
Therapeutic targeting of IL-6 trans-signaling counteracts STAT3 control of the inflammatory infiltrate in experimental arthritis
-
Nowell MA, Williams AS, Carty SA, Scheller J, Hayes AJ, Jones GW, et al. Therapeutic targeting of IL-6 trans-signaling counteracts STAT3 control of the inflammatory infiltrate in experimental arthritis. J Immunol. 2009; 182: 613-622.
-
(2009)
J Immunol
, vol.182
, pp. 613-622
-
-
Nowell, M.A.1
Williams, A.S.2
Carty, S.A.3
Scheller, J.4
Hayes, A.J.5
Jones, G.W.6
-
9
-
-
80052358980
-
Therapeutic strategies for the clinical blockade of IL-6/gp130 signaling
-
doi:10.1172/JCI57158
-
Jones SA, Scheller J, Rose-John S. Therapeutic strategies for the clinical blockade of IL-6/gp130 signaling. J Clin Invest. 2011; 121: 3375-3383. doi:10.1172/JCI57158.
-
(2011)
J Clin Invest
, vol.121
, pp. 3375-3383
-
-
Jones, S.A.1
Scheller, J.2
Rose-John, S.3
-
10
-
-
17644368573
-
Interleukin-6: From basic science to medicine--40 years in immunology
-
Kishimoto T. Interleukin-6: from basic science to medicine--40 years in immunology. Annu Rev Immunol 2005; 23: 1-21.
-
(2005)
Annu Rev Immunol
, vol.23
, pp. 1-21
-
-
Kishimoto, T.1
-
11
-
-
0035160256
-
Soluble gp130 is the natural inhibitor of soluble IL-6R transsignaling responses
-
Jostock T, Müllberg J, Özbek S, Atreya R, Blinn G, Voltz N, et al. Soluble gp130 is the natural inhibitor of soluble IL-6R transsignaling responses. Eur J Biochem. 2001; 268: 160-167.
-
(2001)
Eur J Biochem
, vol.268
, pp. 160-167
-
-
Jostock, T.1
Müllberg, J.2
Özbek, S.3
Atreya, R.4
Blinn, G.5
Voltz, N.6
-
12
-
-
0030614539
-
A designer cytokine with high activity on human hematopoietic progenitor cells
-
Fischer M, Goldschmitt J, Peschel C, Kallen KJ, Brakenhoff JPJ, Wollmer A, et al. A designer cytokine with high activity on human hematopoietic progenitor cells. Nat Biotech. 1997; 15: 142-145.
-
(1997)
Nat Biotech
, vol.15
, pp. 142-145
-
-
Fischer, M.1
Goldschmitt, J.2
Peschel, C.3
Kallen, K.J.4
Brakenhoff, J.P.J.5
Wollmer, A.6
-
13
-
-
0024458160
-
Soluble cytokine receptors are present in normal human urine
-
Novick D, Engelmann H, Wallach D, Rubinstein M. Soluble cytokine receptors are present in normal human urine. J Exp Med. 1989; 170: 1409-1414.
-
(1989)
J Exp Med
, vol.170
, pp. 1409-1414
-
-
Novick, D.1
Engelmann, H.2
Wallach, D.3
Rubinstein, M.4
-
14
-
-
0027398766
-
The soluble interleukin-6 receptor is generated by shedding
-
Müllberg J, Schooltink H, Stoyan T, Gunther M, Graeve L, Buse G, et al. The soluble interleukin-6 receptor is generated by shedding. Eur J Immunol. 1993; 23: 473-480.
-
(1993)
Eur J Immunol
, vol.23
, pp. 473-480
-
-
Müllberg, J.1
Schooltink, H.2
Stoyan, T.3
Gunther, M.4
Graeve, L.5
Buse, G.6
-
15
-
-
0026828552
-
Isolation of an mRNA encoding a soluble form of the human interleukin-6 receptor
-
Lust JA, Donovan KA, Kline MP, Greipp PR, Kyle RA, Maihle NJ. Isolation of an mRNA encoding a soluble form of the human interleukin-6 receptor. Cytokine. 1992; 4: 96-100.
-
(1992)
Cytokine
, vol.4
, pp. 96-100
-
-
Lust, J.A.1
Donovan, K.A.2
Kline, M.P.3
Greipp, P.R.4
Kyle, R.A.5
Maihle, N.J.6
-
16
-
-
33845668702
-
Sleep Enhances IL-6 Trans-Signaling in Humans
-
Dimitrov S, Lange T, Benedict C, Scheller J, Rose-John S, Jones S, et al. Sleep Enhances IL-6 Trans-Signaling in Humans. Faseb J. 2006; 20: 2174-2176.
-
(2006)
Faseb J
, vol.20
, pp. 2174-2176
-
-
Dimitrov, S.1
Lange, T.2
Benedict, C.3
Scheller, J.4
Rose-John, S.5
Jones, S.6
-
17
-
-
79960923986
-
ADAM17: A molecular switch of inflammatory and regenerative responses?
-
Scheller J, Chalaris A, Garbers C, Rose-John S. ADAM17: a molecular switch of inflammatory and regenerative responses? Trends Immunol. 2011; 32: 380-387.
-
(2011)
Trends Immunol
, vol.32
, pp. 380-387
-
-
Scheller, J.1
Chalaris, A.2
Garbers, C.3
Rose-John, S.4
-
18
-
-
0028226196
-
Soluble receptors for cytokines and growth factors: Generation and biological function
-
Rose-John S, Heinrich PC. Soluble receptors for cytokines and growth factors: generation and biological function. Biochem J. 1994; 300: 281-290.
-
(1994)
Biochem J
, vol.300
, pp. 281-290
-
-
Rose-John, S.1
Heinrich, P.C.2
-
19
-
-
0024393839
-
Interleukin-6 triggers the association of its receptor with a possible signal transducer, gp130
-
Taga T, Hibi M, Hirata Y, Yamasaki K, Yasukawa K, Matsuda T, et al. Interleukin-6 triggers the association of its receptor with a possible signal transducer, gp130. Cell. 1989; 58: 573-581.
-
(1989)
Cell
, vol.58
, pp. 573-581
-
-
Taga, T.1
Hibi, M.2
Hirata, Y.3
Yamasaki, K.4
Yasukawa, K.5
Matsuda, T.6
-
20
-
-
0027074343
-
Protein kinase C activity is rate limiting for shedding of the interleukin-6 receptor
-
Müllberg J, Schooltink H, Stoyan T, Heinrich PC, Rose-John S. Protein kinase C activity is rate limiting for shedding of the interleukin-6 receptor. Biochem Biophys Res Commun. 1992; 189: 794-800.
-
(1992)
Biochem Biophys Res Commun
, vol.189
, pp. 794-800
-
-
Müllberg, J.1
Schooltink, H.2
Stoyan, T.3
Heinrich, P.C.4
Rose-John, S.5
-
21
-
-
0028270409
-
The soluble human IL-6 receptor. Mutational characterization of the proteolytic cleavage site
-
Müllberg J, Oberthur W, Lottspeich F, Mehl E, Dittrich E, Graeve L, et al. The soluble human IL-6 receptor. Mutational characterization of the proteolytic cleavage site. J Immunol. 1994; 152: 4958-4968.
-
(1994)
J Immunol
, vol.152
, pp. 4958-4968
-
-
Müllberg, J.1
Oberthur, W.2
Lottspeich, F.3
Mehl, E.4
Dittrich, E.5
Graeve, L.6
-
22
-
-
0033080801
-
C-reactive protein: A physiological activator of interleukin 6 receptor shedding
-
Jones SA, Novick D, Horiuchi S, Yamamoto N, Szalai AJ, Fuller GM. C-reactive protein: a physiological activator of interleukin 6 receptor shedding. J Exp Med. 1999; 189: 599-604.
-
(1999)
J Exp Med
, vol.189
, pp. 599-604
-
-
Jones, S.A.1
Novick, D.2
Horiuchi, S.3
Yamamoto, N.4
Szalai, A.J.5
Fuller, G.M.6
-
23
-
-
0029795014
-
Pore-forming toxins trigger shedding of receptors for interleukin 6 and lipopolysaccharide
-
Walev I, Vollmer P, Palmer M, Bhakdi S, Rose-John S. Pore-forming toxins trigger shedding of receptors for interleukin 6 and lipopolysaccharide. Proc Natl Acad Sci USA. 1996; 93: 7882-7887.
-
(1996)
Proc Natl Acad Sci USA
, vol.93
, pp. 7882-7887
-
-
Walev, I.1
Vollmer, P.2
Palmer, M.3
Bhakdi, S.4
Rose-John, S.5
-
24
-
-
0141866756
-
Cholesterol depletion of the plasma membrane triggers shedding of the human interleukin-6 receptor by TACE and independently of PKC
-
Matthews V, Schuster B, Schütze S, Kallen K-J, Rose-John S. Cholesterol depletion of the plasma membrane triggers shedding of the human interleukin-6 receptor by TACE and independently of PKC. J Biol Chem. 2003; 278: 38829-38839.
-
(2003)
J Biol Chem
, vol.278
, pp. 38829-38839
-
-
Matthews, V.1
Schuster, B.2
Schütze, S.3
Kallen, K.-J.4
Rose-John, S.5
-
25
-
-
0029736417
-
Novel pathogenic mechanism of microbial metalloproteinases: Liberation of membrane-anchored molecules in biologically active form exemplified by studies with the human interleukin-6 receptor
-
Vollmer P, Walev I, Rose-John S, Bhakdi S. Novel pathogenic mechanism of microbial metalloproteinases: liberation of membrane-anchored molecules in biologically active form exemplified by studies with the human interleukin-6 receptor. Infect Immun. 1996; 64: 3646-3651.
-
(1996)
Infect Immun
, vol.64
, pp. 3646-3651
-
-
Vollmer, P.1
Walev, I.2
Rose-John, S.3
Bhakdi, S.4
-
26
-
-
34548856204
-
Apoptosis is a natural stimulus of IL6R shedding and contributes to the pro-inflammatory trans-signaling function of neutrophils
-
Chalaris A, Rabe B, Paliga K, Lange H, Laskay T, Fielding CA, et al. Apoptosis is a natural stimulus of IL6R shedding and contributes to the pro-inflammatory trans-signaling function of neutrophils. Blood. 2007; 110: 1748-1755.
-
(2007)
Blood
, vol.110
, pp. 1748-1755
-
-
Chalaris, A.1
Rabe, B.2
Paliga, K.3
Lange, H.4
Laskay, T.5
Fielding, C.A.6
-
27
-
-
34548844436
-
Attractive shedding
-
DeLeo FR. Attractive shedding. Blood. 2007; 110: 1711-1712.
-
(2007)
Blood
, vol.110
, pp. 1711-1712
-
-
Deleo, F.R.1
-
28
-
-
33646577466
-
Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells
-
Bettelli E, Carrier Y, Gao W, Korn T, Strom TB, Oukka M, et al. Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells. Nature. 2006; 441: 235-238.
-
(2006)
Nature
, vol.441
, pp. 235-238
-
-
Bettelli, E.1
Carrier, Y.2
Gao, W.3
Korn, T.4
Strom, T.B.5
Oukka, M.6
-
29
-
-
34848876937
-
Cutting edge: Trans-signaling via the soluble IL-6R abrogates the induction of FoxP3 in naive CD4+CD25 T cells
-
Dominitzki S, Fantini MC, Neufert C, Nikolaev A, Galle PR, Scheller J, et al. Cutting edge: trans-signaling via the soluble IL-6R abrogates the induction of FoxP3 in naive CD4+CD25 T cells. J Immunol. 2007; 179: 2041-2045.
-
(2007)
J Immunol
, vol.179
, pp. 2041-2045
-
-
Dominitzki, S.1
Fantini, M.C.2
Neufert, C.3
Nikolaev, A.4
Galle, P.R.5
Scheller, J.6
-
30
-
-
47249089967
-
Cutting Edge: Soluble IL-6R Is Produced by IL-6R Ectodomain Shedding in Activated CD4 T Cells
-
Briso EM, Dienz O, Rincon M. Cutting Edge: Soluble IL-6R Is Produced by IL-6R Ectodomain Shedding in Activated CD4 T Cells. J Immunol. 2008; 180: 7102-7126.
-
(2008)
J Immunol
, vol.180
, pp. 7102-7126
-
-
Briso, E.M.1
Dienz, O.2
Rincon, M.3
-
31
-
-
77949881389
-
Loss of CD4+ T cell IL-6R expression during inflammation underlines a role for IL-6 trans signaling in the local maintenance of Th17 cells
-
Jones GW, McLoughlin RM, Hammond VJ, Parker CR, Williams JD, Malhotra R, et al. Loss of CD4+ T cell IL-6R expression during inflammation underlines a role for IL-6 trans signaling in the local maintenance of Th17 cells. J Immunol. 2010; 184: 2130-2139.
-
(2010)
J Immunol
, vol.184
, pp. 2130-2139
-
-
Jones, G.W.1
McLoughlin, R.M.2
Hammond, V.J.3
Parker, C.R.4
Williams, J.D.5
Malhotra, R.6
-
32
-
-
0027293104
-
Soluble forms of the interleukin-6 signal-transducing receptor component gp130 in human serum possessing a potential to inhibit signals through membrane-anchored gp130
-
Narazaki M, Yasukawa K, Saito T, Ohsugi Y, Fukui H, Koishihara Y, et al. Soluble forms of the interleukin-6 signal-transducing receptor component gp130 in human serum possessing a potential to inhibit signals through membrane-anchored gp130. Blood. 1993; 82: 1120-1126.
-
(1993)
Blood
, vol.82
, pp. 1120-1126
-
-
Narazaki, M.1
Yasukawa, K.2
Saito, T.3
Ohsugi, Y.4
Fukui, H.5
Koishihara, Y.6
-
33
-
-
0032562601
-
Identification and characterization of two distinct truncated forms of gp130 and a soluble form of leukemia inhibitory factor receptor alpha-chain in normal human urine and plasma
-
Zhang JG, Zhang Y, Owczarek CM, Ward LD, Moritz RL, Simpson RJ, et al. Identification and characterization of two distinct truncated forms of gp130 and a soluble form of leukemia inhibitory factor receptor alpha-chain in normal human urine and plasma. J Biol Chem. 1998; 273: 10798-10805.
-
(1998)
J Biol Chem
, vol.273
, pp. 10798-10805
-
-
Zhang, J.G.1
Zhang, Y.2
Owczarek, C.M.3
Ward, L.D.4
Moritz, R.L.5
Simpson, R.J.6
-
34
-
-
33646469222
-
Functional characterization of a soluble gp130 isoform and its therapeutic capacity in an experimental model of inflammatory arthritis
-
Richards PJ, Nowell MA, Horiuchi S, McLoughlin RM, Fielding CA, Grau S, et al. Functional characterization of a soluble gp130 isoform and its therapeutic capacity in an experimental model of inflammatory arthritis. Arthr Rheumat. 2006; 54: 1662-1672.
-
(2006)
Arthr Rheumat
, vol.54
, pp. 1662-1672
-
-
Richards, P.J.1
Nowell, M.A.2
Horiuchi, S.3
McLoughlin, R.M.4
Fielding, C.A.5
Grau, S.6
-
35
-
-
0027428924
-
Differential shedding of the two subunits of the interleukin-6 receptor
-
Müllberg J, Dittrich E, Graeve L, Gerhartz C, Yasukawa K, Taga T, et al. Differential shedding of the two subunits of the interleukin-6 receptor. FEBS Lett. 1993; 332: 174-178.
-
(1993)
FEBS Lett
, vol.332
, pp. 174-178
-
-
Müllberg, J.1
Dittrich, E.2
Graeve, L.3
Gerhartz, C.4
Yasukawa, K.5
Taga, T.6
-
36
-
-
0029950150
-
Differential interleukin-6 (IL-6) responses of three established myeloma cell lines in the presence of soluble human IL-6 receptors
-
Diamant M, Hansen MB, Rieneck K, Svenson M, Yasukawa K, Bendtzen K. Differential interleukin-6 (IL-6) responses of three established myeloma cell lines in the presence of soluble human IL-6 receptors. Leuk Res. 1996; 20: 291-301.
-
(1996)
Leuk Res
, vol.20
, pp. 291-301
-
-
Diamant, M.1
Hansen, M.B.2
Rieneck, K.3
Svenson, M.4
Yasukawa, K.5
Bendtzen, K.6
-
37
-
-
0029863504
-
The function of the soluble interleukin 6 (IL-6) receptor in vivo: Sensitization of human soluble IL-6 receptor transgenic mice towards IL-6 and prolongation of the plasma half-life of IL-6
-
Peters M, Jacobs S, Ehlers M, Vollmer P, Müllberg J, Wolf E, et al. The function of the soluble interleukin 6 (IL-6) receptor in vivo: sensitization of human soluble IL-6 receptor transgenic mice towards IL-6 and prolongation of the plasma half-life of IL-6. J Exp Med. 1996; 183: 1399-1406.
-
(1996)
J Exp Med
, vol.183
, pp. 1399-1406
-
-
Peters, M.1
Jacobs, S.2
Ehlers, M.3
Vollmer, P.4
Müllberg, J.5
Wolf, E.6
-
38
-
-
0027303256
-
Structure-function analysis of interleukin-6 utilizing human/murine chimeric molecules. Involvement of two separate domains in receptor binding
-
van Dam M, Müllberg J, Schooltink H, Stoyan T, Brakenhoff JP, Graeve L, et al. Structure-function analysis of interleukin-6 utilizing human/murine chimeric molecules. Involvement of two separate domains in receptor binding. J Biol Chem. 1993; 268: 15285-15290.
-
(1993)
J Biol Chem
, vol.268
, pp. 15285-15290
-
-
van Dam, M.1
Müllberg, J.2
Schooltink, H.3
Stoyan, T.4
Brakenhoff, J.P.5
Graeve, L.6
-
39
-
-
0028331014
-
Development of progressive kidney damage and myeloma kidney in interleukin-6 transgenic mice
-
Fattori E, Della Rocca C, Costa P, Giorgio M, Dente B, Pozzi L, et al. Development of progressive kidney damage and myeloma kidney in interleukin-6 transgenic mice. Blood. 1994; 83: 2570-2579.
-
(1994)
Blood
, vol.83
, pp. 2570-2579
-
-
Fattori, E.1
della Rocca, C.2
Costa, P.3
Giorgio, M.4
Dente, B.5
Pozzi, L.6
-
40
-
-
18244419398
-
Extramedullary expansion of hematopoietic progenitor cells in IL-6/sIL-6R double transgenic mice
-
Peters M, Schirmacher P, Goldschmitt J, Odenthal M, Peschel C, Dienes HP, et al. Extramedullary expansion of hematopoietic progenitor cells in IL-6/sIL-6R double transgenic mice. J Exp Med. 1997; 185: 755-766.
-
(1997)
J Exp Med
, vol.185
, pp. 755-766
-
-
Peters, M.1
Schirmacher, P.2
Goldschmitt, J.3
Odenthal, M.4
Peschel, C.5
Dienes, H.P.6
-
41
-
-
0031858640
-
Hepatocellular Hyperplasia, Plasmacytoma Formation, and Extracellular Hematopoiesis in Interleukin (IL)-6/Soluble IL-6 Receptor Double-Transgenic Mice
-
Schirmacher P, Peters M, Ciliberto G, Fattori E, Lotz J, Meyer zum Büschenfelde KH, et al. Hepatocellular Hyperplasia, Plasmacytoma Formation, and Extracellular Hematopoiesis in Interleukin (IL)-6/Soluble IL-6 Receptor Double-Transgenic Mice. Am J Pathol. 1998; 153: 639-648.
-
(1998)
Am J Pathol
, vol.153
, pp. 639-648
-
-
Schirmacher, P.1
Peters, M.2
Ciliberto, G.3
Fattori, E.4
Lotz, J.5
Meyer zum Büschenfelde, K.H.6
-
42
-
-
0032190524
-
Coexpression of IL-6 and soluble IL-6R causes nodular regenerative hyperplasia and adenomas of the liver
-
Maione D, Di Carlo E, Li W, Musiani P, Modesti A, Peters M, et al. Coexpression of IL-6 and soluble IL-6R causes nodular regenerative hyperplasia and adenomas of the liver. Embo J. 1998; 17: 5588-5597.
-
(1998)
Embo J
, vol.17
, pp. 5588-5597
-
-
Maione, D.1
Di Carlo, E.2
Li, W.3
Musiani, P.4
Modesti, A.5
Peters, M.6
-
43
-
-
0032533949
-
Interleukin-6 and soluble Interleukin-6 Receptor: Direct Stimulation of gp130 and Hematopoiesis
-
Peters M, Müller A, Rose-John S. Interleukin-6 and soluble Interleukin-6 Receptor: Direct Stimulation of gp130 and Hematopoiesis. Blood. 1998; 92: 3495-3504.
-
(1998)
Blood
, vol.92
, pp. 3495-3504
-
-
Peters, M.1
Müller, A.2
Rose-John, S.3
-
44
-
-
0028305730
-
Identification of a region within the cytoplasmic domain of the interleukin-6 (IL-6) signal transducer gp130 important for ligand-induced endocytosis of the IL-6 receptor
-
Dittrich E, Rose-John S, Gerhartz C, Mullberg J, Stoyan T, Yasukawa K, et al. Identification of a region within the cytoplasmic domain of the interleukin-6 (IL-6) signal transducer gp130 important for ligand-induced endocytosis of the IL-6 receptor. J Biol Chem. 1994; 269: 19014-19020.
-
(1994)
J Biol Chem
, vol.269
, pp. 19014-19020
-
-
Dittrich, E.1
Rose-John, S.2
Gerhartz, C.3
Mullberg, J.4
Stoyan, T.5
Yasukawa, K.6
-
45
-
-
0032194108
-
In Vivo and in vitro Activity of the gp130 Stimulating Designer Cytokine Hyper-IL-6
-
Peters M, Blinn G, Solem F, Fischer M, Meyer zum Büschenfelde K-H, Rose-John S. In Vivo and in vitro Activity of the gp130 Stimulating Designer Cytokine Hyper-IL-6. J Immunol. 1998; 161: 3575-3581.
-
(1998)
J Immunol
, vol.161
, pp. 3575-3581
-
-
Peters, M.1
Blinn, G.2
Solem, F.3
Fischer, M.4
Meyer zum Büschenfelde, K.-H.5
Rose-John, S.6
-
46
-
-
0025303609
-
Studies on the structure and regulation of the human hepatic interleukin-6 receptor
-
Rose-John S, Schooltink H, Lenz D, Hipp E, Dufhues G, Schmitz H, et al. Studies on the structure and regulation of the human hepatic interleukin-6 receptor. Eur J Biochem. 1990; 190: 79-83.
-
(1990)
Eur J Biochem
, vol.190
, pp. 79-83
-
-
Rose-John, S.1
Schooltink, H.2
Lenz, D.3
Hipp, E.4
Dufhues, G.5
Schmitz, H.6
-
47
-
-
0035852678
-
Distinct role of gp130 activation in promoting self-renewal divisions by mitogenically stimulated murine hematopoietic cells
-
Audet J, Miller CL, Rose-John S, Piret JM, Eaves CJ. Distinct role of gp130 activation in promoting self-renewal divisions by mitogenically stimulated murine hematopoietic cells. Proc Natl Acad Sci USA. 2001; 98: 1757-1762.
-
(2001)
Proc Natl Acad Sci USA
, vol.98
, pp. 1757-1762
-
-
Audet, J.1
Miller, C.L.2
Rose-John, S.3
Piret, J.M.4
Eaves, C.J.5
-
48
-
-
0032539893
-
Sympathetic Neurons can produce and respond to Interleukin-6
-
März P, Cheng J-C, Gadient RA, Patterson P, Stoyan T, Otten U, et al. Sympathetic Neurons can produce and respond to Interleukin-6. Proc Natl Acad Sci USA. 1998; 95: 3251-3256.
-
(1998)
Proc Natl Acad Sci USA
, vol.95
, pp. 3251-3256
-
-
März, P.1
Cheng, J.-C.2
Gadient, R.A.3
Patterson, P.4
Stoyan, T.5
Otten, U.6
-
49
-
-
0345104338
-
Role of Interleukin-6 and soluble IL-6 Receptor in Region Specific Induction of Astrocytic Differentiation and Neurotrophin Expression
-
März P, Heese K, Dimitriades-Schmutz B, Rose-John S, Otten U. Role of Interleukin-6 and soluble IL-6 Receptor in Region Specific Induction of Astrocytic Differentiation and Neurotrophin Expression. Glia. 1999; 26: 191-200.
-
(1999)
Glia
, vol.26
, pp. 191-200
-
-
März, P.1
Heese, K.2
Dimitriades-Schmutz, B.3
Rose-John, S.4
Otten, U.5
-
50
-
-
0032846613
-
Novel Path of activation of primary human smooth muscle cells: Upregulation of gp130 creates an autocrine activation loop by IL-6 and its soluble receptor
-
Klouche M, Bhakdi S, Hemmes M, Rose-John S. Novel Path of activation of primary human smooth muscle cells: upregulation of gp130 creates an autocrine activation loop by IL-6 and its soluble receptor. J Immunol. 1999; 163: 4583-4589.
-
(1999)
J Immunol
, vol.163
, pp. 4583-4589
-
-
Klouche, M.1
Bhakdi, S.2
Hemmes, M.3
Rose-John, S.4
-
51
-
-
0036219910
-
Ligand/receptor signaling threshold (LIST) model accounts for gp130-mediated embryonic stem cell self-renewal responses to LIF and HIL-6
-
Viswanathan S, Benatar T, Rose-John S, Lauffenburger DA, Zandstra PW. Ligand/receptor signaling threshold (LIST) model accounts for gp130-mediated embryonic stem cell self-renewal responses to LIF and HIL-6. Stem cells (Dayton, Ohio). 2002; 20: 119-138.
-
(2002)
Stem Cells (Dayton, Ohio)
, vol.20
, pp. 119-138
-
-
Viswanathan, S.1
Benatar, T.2
Rose-John, S.3
Lauffenburger, D.A.4
Zandstra, P.W.5
-
52
-
-
3542996260
-
Maintenance of pluripotency in human embryonic stem cells is Stat3 independent
-
Humphrey RK, Beattie GM, Lopez AD, Bucay N, King CC, Firpo M, et al. Maintenance of pluripotency in human embryonic stem cells is Stat3 independent. Stem cells (Dayton, Ohio). 2004; 22: 522-530.
-
(2004)
Stem Cells (Dayton, Ohio)
, vol.22
, pp. 522-530
-
-
Humphrey, R.K.1
Beattie, G.M.2
Lopez, A.D.3
Bucay, N.4
King, C.C.5
Firpo, M.6
-
53
-
-
33748848714
-
Interleukin-6 Biology is Coordinated by Membrane-Bound and Soluble Receptors: Role in Inflammation and Cancer
-
Rose-John S, Scheller J, Elson G, Jones S. Interleukin-6 Biology is Coordinated by Membrane-Bound and Soluble Receptors: Role in Inflammation and Cancer. J Leuk Biol. 2006; 80: 227-236.
-
(2006)
J Leuk Biol
, vol.80
, pp. 227-236
-
-
Rose-John, S.1
Scheller, J.2
Elson, G.3
Jones, S.4
-
54
-
-
34248341267
-
The IL-6/sIL-6R complex as a novel target for therapeutic approaches
-
Rose-John S, Waetzig GH, Scheller J, Grotzinger J, Seegert D. The IL-6/sIL-6R complex as a novel target for therapeutic approaches. Expert Opin Ther Targets. 2007; 11: 613-624.
-
(2007)
Expert Opin Ther Targets
, vol.11
, pp. 613-624
-
-
Rose-John, S.1
Waetzig, G.H.2
Scheller, J.3
Grotzinger, J.4
Seegert, D.5
-
55
-
-
84857411475
-
Hitting a complex target: An update on interleukin-6 trans-signalling
-
Waetzig GH, Rose-John S. Hitting a complex target: an update on interleukin-6 trans-signalling. Expert Opin Ther Targets. 2012; 16: 225-236.
-
(2012)
Expert Opin Ther Targets
, vol.16
, pp. 225-236
-
-
Waetzig, G.H.1
Rose-John, S.2
-
56
-
-
10644250867
-
No inhibition of IL-27 signaling by soluble gp130
-
Scheller J, Schuster B, Holscher C, Yoshimoto T, Rose-John S. No inhibition of IL-27 signaling by soluble gp130. Biochem Biophys Res Commun. 2005; 326: 724-728.
-
(2005)
Biochem Biophys Res Commun
, vol.326
, pp. 724-728
-
-
Scheller, J.1
Schuster, B.2
Holscher, C.3
Yoshimoto, T.4
Rose-John, S.5
-
57
-
-
27944444522
-
Dimerization of the cytokine receptors gp130 and LIFR analysed in single cells
-
Giese B, Roderburg C, Sommerauer M, Wortmann SB, Metz S, Heinrich PC, et al. Dimerization of the cytokine receptors gp130 and LIFR analysed in single cells. Journal of cell science. 2005; 118: 5129-5140.
-
(2005)
Journal of Cell Science
, vol.118
, pp. 5129-5140
-
-
Giese, B.1
Roderburg, C.2
Sommerauer, M.3
Wortmann, S.B.4
Metz, S.5
Heinrich, P.C.6
-
58
-
-
33745218277
-
Gp130 Dimerization in the Absence of Ligand: Preformed Cytokine Receptor Complexes
-
Tenhumberg S, Schuster B, Zhu L, Kovaleva M, Scheller J, Kallen KJ, et al. gp130 Dimerization in the Absence of Ligand: preformed Cytokine Receptor Complexes. Biochem Biophys Res Commun. 2006; 346: 649-657.
-
(2006)
Biochem Biophys Res Commun
, vol.346
, pp. 649-657
-
-
Tenhumberg, S.1
Schuster, B.2
Zhu, L.3
Kovaleva, M.4
Scheller, J.5
Kallen, K.J.6
-
59
-
-
33745598848
-
Forced dimerization of gp130 leads to constitutive STAT3 activation, cytokine independent growth and blockade of differentiation of embryonic stem cells
-
Stuhlmann-Laeisz C, Lang S, Chalaris A, Paliga K, Sudarman E, Eichler J, et al. Forced dimerization of gp130 leads to constitutive STAT3 activation, cytokine independent growth and blockade of differentiation of embryonic stem cells. Mol Biol Cell. 2006; 17: 2986-2995.
-
(2006)
Mol Biol Cell
, vol.17
, pp. 2986-2995
-
-
Stuhlmann-Laeisz, C.1
Lang, S.2
Chalaris, A.3
Paliga, K.4
Sudarman, E.5
Eichler, J.6
-
60
-
-
77955106518
-
Forced homo- and heterodimerization of all gp130-type receptor complexes leads to constitutive ligand-independent signaling and cytokine-independent growth
-
Suthaus J, Tillmann A, Lorenzen I, Bulanova E, Rose-John S, Scheller J. Forced homo- and heterodimerization of all gp130-type receptor complexes leads to constitutive ligand-independent signaling and cytokine-independent growth. Mol Biol Cell. 2010; 21: 2797-2807.
-
(2010)
Mol Biol Cell
, vol.21
, pp. 2797-2807
-
-
Suthaus, J.1
Tillmann, A.2
Lorenzen, I.3
Bulanova, E.4
Rose-John, S.5
Scheller, J.6
-
61
-
-
0037434888
-
The human interleukin-6 (IL-6) receptor exists as a preformed dimer in the plasma membrane
-
Schuster B, Meinert W, Rose-John S, Kallen K-J. The human interleukin-6 (IL-6) receptor exists as a preformed dimer in the plasma membrane. FEBS Lett. 2003; 538: 113-116.
-
(2003)
FEBS Lett
, vol.538
, pp. 113-116
-
-
Schuster, B.1
Meinert, W.2
Rose-John, S.3
Kallen, K.-J.4
-
62
-
-
0028321886
-
Interleukin-6 serum levels in patients with gynecological tumors
-
Scambia G, Testa U, Panici PB, Martucci R, Foti E, Petrini M, et al. Interleukin-6 serum levels in patients with gynecological tumors. Int J Cancer. 1994; 57: 318-323.
-
(1994)
Int J Cancer
, vol.57
, pp. 318-323
-
-
Scambia, G.1
Testa, U.2
Panici, P.B.3
Martucci, R.4
Foti, E.5
Petrini, M.6
-
63
-
-
0024529891
-
The complex pattern of cytokines in serum from patients with meningococcal septic shock
-
Waage A, Brandtzaeg P, Halstensen A, Kierulf P, Espevik T. The complex pattern of cytokines in serum from patients with meningococcal septic shock. J Exp Med. 1989; 169: 333-338.
-
(1989)
J Exp Med
, vol.169
, pp. 333-338
-
-
Waage, A.1
Brandtzaeg, P.2
Halstensen, A.3
Kierulf, P.4
Espevik, T.5
-
64
-
-
0042834261
-
Soluble IL-6 Receptor Governs IL-6 Activity in Experimental Arthritis: Blockade of Arthritis Severity by Soluble Glycoprotein 130
-
Nowell MA, Richards PJ, Horiuchi S, Yamamoto N, Rose-John S, Topley N, et al. Soluble IL-6 Receptor Governs IL-6 Activity in Experimental Arthritis: Blockade of Arthritis Severity by Soluble Glycoprotein 130. J Immunol. 2003; 171: 3202-3209.
-
(2003)
J Immunol
, vol.171
, pp. 3202-3209
-
-
Nowell, M.A.1
Richards, P.J.2
Horiuchi, S.3
Yamamoto, N.4
Rose-John, S.5
Topley, N.6
-
65
-
-
0026554229
-
Human soluble IL-6 receptor: Its detection and enhanced release by HIV infection
-
Honda M, Yamamoto S, Cheng M, Yasukawa K, Suzuki H, Saito T, et al. Human soluble IL-6 receptor: its detection and enhanced release by HIV infection. J Immunol. 1992; 148: 2175-2180.
-
(1992)
J Immunol
, vol.148
, pp. 2175-2180
-
-
Honda, M.1
Yamamoto, S.2
Cheng, M.3
Yasukawa, K.4
Suzuki, H.5
Saito, T.6
-
66
-
-
0032731374
-
CSF and serum levels of soluble interleukin-6 receptors (sIL-6R and sgp130), but not of interleukin-6 are altered in multiple sclerosis
-
Padberg F, Feneberg W, Schmidt S, Schwarz MJ, Korschenhausen D, Greenberg BD, et al. CSF and serum levels of soluble interleukin-6 receptors (sIL-6R and sgp130), but not of interleukin-6 are altered in multiple sclerosis. J Neuroimmunol. 1999; 99: 218-223.
-
(1999)
J Neuroimmunol
, vol.99
, pp. 218-223
-
-
Padberg, F.1
Feneberg, W.2
Schmidt, S.3
Schwarz, M.J.4
Korschenhausen, D.5
Greenberg, B.D.6
-
67
-
-
20144375594
-
The IL-6R alpha chain controls lung CD4+CD4+CD25+T regulatory cell development and function during allergic airway inflammation in vivo
-
Doganci A, Eigenbrod T, Krug N, De Sanctis GT, Hausding M, Erpenbeck VJ, et al. The IL-6R alpha chain controls lung CD4+CD4+CD25+T regulatory cell development and function during allergic airway inflammation in vivo. J Clin Invest. 2005; 115: 313-325.
-
(2005)
J Clin Invest
, vol.115
, pp. 313-325
-
-
Doganci, A.1
Eigenbrod, T.2
Krug, N.3
de Sanctis, G.T.4
Hausding, M.5
Erpenbeck, V.J.6
-
68
-
-
84856221966
-
Transsignaling of interleukin-6 crucially contributes to atherosclerosis in mice
-
Schuett H, Oestreich R, Waetzig GH, Annema W, Luchtefeld M, Hillmer A, et al. Transsignaling of interleukin-6 crucially contributes to atherosclerosis in mice. Arterioscler Thromb Vasc Biol. 2012; 32: 281-290.
-
(2012)
Arterioscler Thromb Vasc Biol
, vol.32
, pp. 281-290
-
-
Schuett, H.1
Oestreich, R.2
Waetzig, G.H.3
Annema, W.4
Luchtefeld, M.5
Hillmer, A.6
-
70
-
-
83355163340
-
Inhibition of classic signaling is a novel function of soluble glycoprotein 130 (sgp130), which is controlled by the ratio of interleukin 6 and soluble interleukin 6 receptor
-
Garbers C, Thaiss W, Jones GW, Waetzig GH, Lorenzen I, Guilhot F, et al. Inhibition of classic signaling is a novel function of soluble glycoprotein 130 (sgp130), which is controlled by the ratio of interleukin 6 and soluble interleukin 6 receptor. J Biol Chem. 2011; 286: 42959-42970.
-
(2011)
J Biol Chem
, vol.286
, pp. 42959-42970
-
-
Garbers, C.1
Thaiss, W.2
Jones, G.W.3
Waetzig, G.H.4
Lorenzen, I.5
Guilhot, F.6
-
71
-
-
84859210770
-
Interleukin-6 receptor pathways in coronary heart disease: A collaborative meta-analysis of 82 studies
-
Sarwar N, Butterworth AS, Freitag DF, Gregson J, Willeit P, Gorman DN, et al. Interleukin-6 receptor pathways in coronary heart disease: a collaborative meta-analysis of 82 studies. Lancet. 2012; 379: 1205-1213.
-
(2012)
Lancet
, vol.379
, pp. 1205-1213
-
-
Sarwar, N.1
Butterworth, A.S.2
Freitag, D.F.3
Gregson, J.4
Willeit, P.5
Gorman, D.N.6
-
72
-
-
84859215358
-
The interleukin-6 receptor as a target for prevention of coronary heart disease: A mendelian randomisation analysis
-
Hingorani AD, Casas JP. The interleukin-6 receptor as a target for prevention of coronary heart disease: a mendelian randomisation analysis. Lancet. 2012; 379: 1214-1224.
-
(2012)
Lancet
, vol.379
, pp. 1214-1224
-
-
Hingorani, A.D.1
Casas, J.P.2
-
73
-
-
84859218984
-
The interleukin-6 pathway and atherosclerosis
-
Boekholdt SM, Stroes ES. The interleukin-6 pathway and atherosclerosis. Lancet. 2012; 379: 1176-118.
-
(2012)
Lancet
, vol.379
, pp. 1176-1178
-
-
Boekholdt, S.M.1
Stroes, E.S.2
-
74
-
-
84864229482
-
The interleukin 6 pathway and atherosclerosis
-
Scheller J, Rose-John S. The interleukin 6 pathway and atherosclerosis. Lancet. 2012; 380: 338.
-
(2012)
Lancet
, vol.380
, pp. 338
-
-
Scheller, J.1
Rose-John, S.2
-
75
-
-
84865377662
-
Therapeutic targeting of interleukin-6 trans-signaling does not affect the outcome of experimental tuberculosis
-
in press
-
Sodenkamp J, Waetzig GH, Scheller J, Seegert D, Grotzinger J, Rose-John S, et al. Therapeutic targeting of interleukin-6 trans-signaling does not affect the outcome of experimental tuberculosis. Immunobiology. 2012, in press
-
(2012)
Immunobiology
-
-
Sodenkamp, J.1
Waetzig, G.H.2
Scheller, J.3
Seegert, D.4
Grotzinger, J.5
Rose-John, S.6
-
76
-
-
58649108302
-
IL-6 and STAT3 signaling is required for survival of intestinal epithelial cells and colitis associated cancer
-
Grivennikov S, Karin E, Terzic J, Mucida D, Yu G-Y, Vallabhapurapu S, et al. IL-6 and STAT3 signaling is required for survival of intestinal epithelial cells and colitis associated cancer. Cancer Cell. 2009; 16: 103-113.
-
(2009)
Cancer Cell
, vol.16
, pp. 103-113
-
-
Grivennikov, S.1
Karin, E.2
Terzic, J.3
Mucida, D.4
Yu, G.-Y.5
Vallabhapurapu, S.6
-
77
-
-
45549097533
-
IL-6-dependent mucosal protection prevents establishment of a microbial niche for attaching/effacing lesion-forming enteric bacterial pathogens
-
Dann SM, Spehlmann ME, Hammond DC, Iimura M, Hase K, Choi LJ, et al. IL-6-dependent mucosal protection prevents establishment of a microbial niche for attaching/effacing lesion-forming enteric bacterial pathogens. J Immunol. 2008; 180: 6816-6826.
-
(2008)
J Immunol
, vol.180
, pp. 6816-6826
-
-
Dann, S.M.1
Spehlmann, M.E.2
Hammond, D.C.3
Iimura, M.4
Hase, K.5
Choi, L.J.6
-
78
-
-
5644252874
-
TGF-beta suppresses tumor progression in colon cancer by inhibition of IL-6 trans-signaling
-
Becker C, Fantini MC, Schramm C, Lehr HA, Wirtz S, Nikolaev A, et al. TGF-beta suppresses tumor progression in colon cancer by inhibition of IL-6 trans-signaling. Immunity. 2004; 21: 491-501.
-
(2004)
Immunity
, vol.21
, pp. 491-501
-
-
Becker, C.1
Fantini, M.C.2
Schramm, C.3
Lehr, H.A.4
Wirtz, S.5
Nikolaev, A.6
-
79
-
-
79957656408
-
Selective blockade of interleukin-6 trans-signaling improves survival in a murine polymicrobial sepsis model
-
Barkhausen T, Tschernig T, Rosenstiel P, van Griensven M, Vonberg RP, Dorsch M, et al. Selective blockade of interleukin-6 trans-signaling improves survival in a murine polymicrobial sepsis model. Crit Care Med. 2011; 39: 1407-1413.
-
(2011)
Crit Care Med
, vol.39
, pp. 1407-1413
-
-
Barkhausen, T.1
Tschernig, T.2
Rosenstiel, P.3
van Griensven, M.4
Vonberg, R.P.5
Dorsch, M.6
-
80
-
-
77649271394
-
ADAM17-mediated shedding of the IL6R induces cleavage of the membrane stub by gamma-secretase
-
Chalaris A, Gewiese J, Paliga K, Fleig L, Schneede A, Krieger K, et al. ADAM17-mediated shedding of the IL6R induces cleavage of the membrane stub by gamma-secretase. Biochim Biophys Acta. 2010; 1803: 234-245.
-
(2010)
Biochim Biophys Acta
, vol.1803
, pp. 234-245
-
-
Chalaris, A.1
Gewiese, J.2
Paliga, K.3
Fleig, L.4
Schneede, A.5
Krieger, K.6
-
81
-
-
0031060368
-
Human herpesvirus 8 encodes a homolog of interleukin-6
-
Neipel F, Albrecht JC, Ensser A, Huang YQ, Li JJ, Friedman Kien AE, et al. Human herpesvirus 8 encodes a homolog of interleukin-6. J Virol. 1997; 71: 839-842.
-
(1997)
J Virol
, vol.71
, pp. 839-842
-
-
Neipel, F.1
Albrecht, J.C.2
Ensser, A.3
Huang, Y.Q.4
Li, J.J.5
Friedman Kien, A.E.6
-
82
-
-
0030852894
-
A Kaposi's Sarcoma-associated Herpesvirus-encoded Cytokine Homolog (vIL-6) Activates Signaling through the Shared gp130 Receptor Subunit
-
Molden J, Chang Y, You Y, Moore PS, Goldsmith MA. A Kaposi's Sarcoma-associated Herpesvirus-encoded Cytokine Homolog (vIL-6) Activates Signaling through the Shared gp130 Receptor Subunit. J Biol Chem. 1997; 272: 19625-19631.
-
(1997)
J Biol Chem
, vol.272
, pp. 19625-19631
-
-
Molden, J.1
Chang, Y.2
You, Y.3
Moore, P.S.4
Goldsmith, M.A.5
-
83
-
-
0342264579
-
IL-6-Receptor Independent Stimulation of Human gp130 by Viral IL-6
-
Müllberg J, Geib T, Jostock T, Hoischen SH, Vollmer P, Voltz N, et al. IL-6-Receptor Independent Stimulation of Human gp130 by Viral IL-6. J Immunol. 2000; 164: 4672-4677.
-
(2000)
J Immunol
, vol.164
, pp. 4672-4677
-
-
Müllberg, J.1
Geib, T.2
Jostock, T.3
Hoischen, S.H.4
Vollmer, P.5
Voltz, N.6
-
84
-
-
0001640974
-
Human herpes virus 8 interleukin-6 homologue triggers gp130 on neuronal and hematopoietic cells
-
Hoischen SH, Vollmer P, Marz P, Ozbek S, Gotze KS, Peschel C, et al. Human herpes virus 8 interleukin-6 homologue triggers gp130 on neuronal and hematopoietic cells. Eur J Biochem/FEBS J. 2000; 267: 3604-3612.
-
(2000)
Eur J Biochem/FEBS J
, vol.267
, pp. 3604-3612
-
-
Hoischen, S.H.1
Vollmer, P.2
Marz, P.3
Ozbek, S.4
Gotze, K.S.5
Peschel, C.6
-
85
-
-
0035896394
-
Structure of an extracellular gp130 cytokine receptor signaling complex
-
Chow D, He X, Snow AL, Rose-John S, Garcia KC. Structure of an extracellular gp130 cytokine receptor signaling complex. Science. 2001; 291: 2150-2155.
-
(2001)
Science
, vol.291
, pp. 2150-2155
-
-
Chow, D.1
He, X.2
Snow, A.L.3
Rose-John, S.4
Garcia, K.C.5
-
86
-
-
65349181345
-
Unraveling viral interleukin-6 binding to gp130 and activation of STAT-signaling pathways independently of the interleukin-6 receptor
-
Adam N, Rabe B, Suthaus J, Grotzinger J, Rose-John S, Scheller J. Unraveling viral interleukin-6 binding to gp130 and activation of STAT-signaling pathways independently of the interleukin-6 receptor. J Virol. 2009; 83: 5117-5126.
-
(2009)
J Virol
, vol.83
, pp. 5117-5126
-
-
Adam, N.1
Rabe, B.2
Suthaus, J.3
Grotzinger, J.4
Rose-John, S.5
Scheller, J.6
-
87
-
-
33748653151
-
Abrogation of viral interleukin-6 (vIL-6)-induced signaling by intracellular retention and neutralization of vIL-6 with an anti-vIL-6 single-chain antibody selected by phage display
-
Kovaleva M, Bussmeyer I, Rabe B, Grotzinger J, Sudarman E, Eichler J, et al. Abrogation of viral interleukin-6 (vIL-6)-induced signaling by intracellular retention and neutralization of vIL-6 with an anti-vIL-6 single-chain antibody selected by phage display. J Virol. 2006; 80: 8510-8520.
-
(2006)
J Virol
, vol.80
, pp. 8510-8520
-
-
Kovaleva, M.1
Bussmeyer, I.2
Rabe, B.3
Grotzinger, J.4
Sudarman, E.5
Eichler, J.6
-
88
-
-
10644253485
-
Kaposi's sarcoma-associated herpesvirus-encoded viral interleukin-6 is secreted and modified differently than human interleukin-6: Evidence for a unique autocrine signaling mechanism
-
Meads MB, Medveczky PG. Kaposi's sarcoma-associated herpesvirus-encoded viral interleukin-6 is secreted and modified differently than human interleukin-6: evidence for a unique autocrine signaling mechanism. J Biol Chem. 2004; 279: 51793-51803.
-
(2004)
J Biol Chem
, vol.279
, pp. 51793-51803
-
-
Meads, M.B.1
Medveczky, P.G.2
-
89
-
-
0037165909
-
Human herpesvirus 8-derived viral IL-6 induces PTX3 expression in Kaposi's sarcoma cells
-
Klouche M, Brockmeyer N, Knabbe C, Rose-John S. Human herpesvirus 8-derived viral IL-6 induces PTX3 expression in Kaposi's sarcoma cells. Aids. 2002; 16: F9-18.
-
(2002)
Aids
, vol.16
-
-
Klouche, M.1
Brockmeyer, N.2
Knabbe, C.3
Rose-John, S.4
-
91
-
-
79955482665
-
Viral Interleukin-6: Structure, pathophysiology and strategies of neutralization
-
Suthaus J, Adam N, Grotzinger J, Scheller J, Rose-John S. Viral Interleukin-6: Structure, pathophysiology and strategies of neutralization. Eur J Cell Biol. 2011; 90: 495-504.
-
(2011)
Eur J Cell Biol
, vol.90
, pp. 495-504
-
-
Suthaus, J.1
Adam, N.2
Grotzinger, J.3
Scheller, J.4
Rose-John, S.5
-
92
-
-
24744447422
-
Viral IL-6 blocks neutrophil infiltration during acute inflammation
-
Fielding CA, McLoughlin RM, Colmont CS, Kovaleva M, Harris DA, Rose-John S, et al. Viral IL-6 blocks neutrophil infiltration during acute inflammation. J Immunol. 2005; 175: 4024-4029.
-
(2005)
J Immunol
, vol.175
, pp. 4024-4029
-
-
Fielding, C.A.1
McLoughlin, R.M.2
Colmont, C.S.3
Kovaleva, M.4
Harris, D.A.5
Rose-John, S.6
-
93
-
-
84861851475
-
HHV-8-encoded viral IL-6 collaborates with mouse IL-6 in the development of multicentric Castleman disease in mice
-
Suthaus J, Stuhlmann-Laeisz C, Tompkins VS, Rosean TR, Klapper W, Tosato G, et al. HHV-8-encoded viral IL-6 collaborates with mouse IL-6 in the development of multicentric Castleman disease in mice. Blood. 2012; 119: 5173-5181.
-
(2012)
Blood
, vol.119
, pp. 5173-5181
-
-
Suthaus, J.1
Stuhlmann-Laeisz, C.2
Tompkins, V.S.3
Rosean, T.R.4
Klapper, W.5
Tosato, G.6
-
94
-
-
0029166033
-
Kaposi's sarcoma-associated herpesvirus-like DNA sequences in multicentric Castleman's disease
-
Soulier J, Grollet L, Oksenhendler E, Cacoub P, Cazals Hatem D, Babinet P, et al. Kaposi's sarcoma-associated herpesvirus-like DNA sequences in multicentric Castleman's disease. Blood. 1995; 86: 1276-1280.
-
(1995)
Blood
, vol.86
, pp. 1276-1280
-
-
Soulier, J.1
Grollet, L.2
Oksenhendler, E.3
Cacoub, P.4
Cazals Hatem, D.5
Babinet, P.6
-
95
-
-
27144488346
-
Humanized anti-interleukin-6 receptor antibody treatment of multicentric Castleman disease
-
Nishimoto N, Kanakura Y, Aozasa K, Johkoh T, Nakamura M, Nakano S, et al. Humanized anti-interleukin-6 receptor antibody treatment of multicentric Castleman disease. Blood. 2005; 106: 2627-3262.
-
(2005)
Blood
, vol.106
, pp. 2627-3262
-
-
Nishimoto, N.1
Kanakura, Y.2
Aozasa, K.3
Johkoh, T.4
Nakamura, M.5
Nakano, S.6
-
96
-
-
58649101347
-
Gp130-mediated Stat3 activation in enterocytes regulates cell survival and cell-cycle progression during colitis-associated tumorigenesis
-
Bollrath J, Phesse TJ, von Burstin VA, Putoczki T, Bennecke M, Bateman T, et al. gp130-mediated Stat3 activation in enterocytes regulates cell survival and cell-cycle progression during colitis-associated tumorigenesis. Cancer Cell. 2009; 15: 91-102.
-
(2009)
Cancer Cell
, vol.15
, pp. 91-102
-
-
Bollrath, J.1
Phesse, T.J.2
von Burstin, V.A.3
Putoczki, T.4
Bennecke, M.5
Bateman, T.6
-
98
-
-
18344410191
-
Blockade of IL-6 transsignaling abrogates established experimental colitis in mice by suppression of the antiapoptotic resistance of lamina propria T cells
-
Atreya R, Mudter J, Finotto S, Müllberg J, Jostock T, Wirtz S, et al. Blockade of IL-6 transsignaling abrogates established experimental colitis in mice by suppression of the antiapoptotic resistance of lamina propria T cells. Nat Med. 2000; 6: 583-588.
-
(2000)
Nat Med
, vol.6
, pp. 583-588
-
-
Atreya, R.1
Mudter, J.2
Finotto, S.3
Müllberg, J.4
Jostock, T.5
Wirtz, S.6
-
99
-
-
33747774200
-
STAT3 activation via interleukin 6 trans-signalling contributes to ileitis in SAMP1/Yit mice
-
Mitsuyama K, Matsumoto S, Rose-John S, Suzuki A, Hara T, Tomiyasu N, et al. STAT3 activation via interleukin 6 trans-signalling contributes to ileitis in SAMP1/Yit mice. Gut. 2006; 55: 1263-1269.
-
(2006)
Gut
, vol.55
, pp. 1263-1269
-
-
Mitsuyama, K.1
Matsumoto, S.2
Rose-John, S.3
Suzuki, A.4
Hara, T.5
Tomiyasu, N.6
-
100
-
-
38949164424
-
Transgenic blockade of interleukin 6 transsignaling abrogates inflammation
-
Rabe B, Chalaris A, May U, Waetzig GH, Seegert D, Williams AS, et al. Transgenic blockade of interleukin 6 transsignaling abrogates inflammation. Blood. 2008; 111: 1021-1028.
-
(2008)
Blood
, vol.111
, pp. 1021-1028
-
-
Rabe, B.1
Chalaris, A.2
May, U.3
Waetzig, G.H.4
Seegert, D.5
Williams, A.S.6
-
101
-
-
79251578016
-
IL-6 trans-signaling modulates TLR4-dependent inflammatory responses via STAT3
-
Greenhill CJ, Rose-John S, Lissilaa R, Ferlin W, Ernst M, Hertzog PJ, et al. IL-6 trans-signaling modulates TLR4-dependent inflammatory responses via STAT3. Journal of immunology. 2011; 186: 1199-1208.
-
(2011)
Journal of Immunology
, vol.186
, pp. 1199-1208
-
-
Greenhill, C.J.1
Rose-John, S.2
Lissilaa, R.3
Ferlin, W.4
Ernst, M.5
Hertzog, P.J.6
-
102
-
-
34447572925
-
Local blockade of IL-6R signaling induces lung CD4+ T cell apoptosis in a murine model of asthma via regulatory T cells
-
Finotto S, Eigenbrod T, Karwot R, Boross I, Doganci A, Ito H, et al. Local blockade of IL-6R signaling induces lung CD4+ T cell apoptosis in a murine model of asthma via regulatory T cells. Int Immunol. 2007; 19: 685-693.
-
(2007)
Int Immunol
, vol.19
, pp. 685-693
-
-
Finotto, S.1
Eigenbrod, T.2
Karwot, R.3
Boross, I.4
Doganci, A.5
Ito, H.6
-
103
-
-
77949326158
-
Essential roles of IL-6 trans-signaling in colonic epithelial cells, induced by the IL-6/soluble-IL-6 receptor derived from lamina propria macrophages, on the development of colitis-associated premalignant cancer in a murine model
-
Matsumoto S, Hara T, Mitsuyama K, Yamamoto M, Tsuruta O, Sata M, et al. Essential roles of IL-6 trans-signaling in colonic epithelial cells, induced by the IL-6/soluble-IL-6 receptor derived from lamina propria macrophages, on the development of colitis-associated premalignant cancer in a murine model. J Immunol. 2010; 184: 1543-1551.
-
(2010)
J Immunol
, vol.184
, pp. 1543-1551
-
-
Matsumoto, S.1
Hara, T.2
Mitsuyama, K.3
Yamamoto, M.4
Tsuruta, O.5
Sata, M.6
-
104
-
-
78751549236
-
IL-6 trans-signaling in formation and progression of malignant ascites in ovarian cancer
-
Lo CW, Chen MW, Hsiao M, Wang S, Chen CA, Hsiao SM, et al. IL-6 trans-signaling in formation and progression of malignant ascites in ovarian cancer. Cancer Res. 2011; 71: 424-434.
-
(2011)
Cancer Res
, vol.71
, pp. 424-434
-
-
Lo, C.W.1
Chen, M.W.2
Hsiao, M.3
Wang, S.4
Chen, C.A.5
Hsiao, S.M.6
-
105
-
-
79953756112
-
Stat3/Socs3 activation by IL-6 transsignaling promotes progression of pancreatic intraepithelial neoplasia and development of pancreatic cancer
-
Lesina M, Kurkowski MU, Ludes K, Rose-John S, Treiber M, Klöppel G, et al. Stat3/Socs3 activation by IL-6 transsignaling promotes progression of pancreatic intraepithelial neoplasia and development of pancreatic cancer. Cancer Cell. 2011; 19: 456-469.
-
(2011)
Cancer Cell
, vol.19
, pp. 456-469
-
-
Lesina, M.1
Kurkowski, M.U.2
Ludes, K.3
Rose-John, S.4
Treiber, M.5
Klöppel, G.6
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