메뉴 건너뛰기




Volumn 8, Issue 9, 2012, Pages 1237-1247

Il-6 trans-signaling via the soluble IL-6 receptor: Importance for the proinflammatory activities of IL-6

Author keywords

IL 6; IL 6 receptor; Inflammation; Inflammation associated cancer; Shedding; Soluble receptor

Indexed keywords

GLYCOPROTEIN GP 130; INTERLEUKIN 6; INTERLEUKIN 6 RECEPTOR;

EID: 84869797922     PISSN: 14492288     EISSN: None     Source Type: Journal    
DOI: 10.7150/ijbs.4989     Document Type: Review
Times cited : (743)

References (105)
  • 1
    • 0022499547 scopus 로고
    • Complementary DNA for a novel human interleukin (BSF-2) that induces B lymphocytes to produce immunoglobulin
    • Hirano T, Yasukawa K, Harada H, Taga T, Watanabe Y, Matsuda T, et al. Complementary DNA for a novel human interleukin (BSF-2) that induces B lymphocytes to produce immunoglobulin. Nature. 1986; 324: 73-76.
    • (1986) Nature , vol.324 , pp. 73-76
    • Hirano, T.1    Yasukawa, K.2    Harada, H.3    Taga, T.4    Watanabe, Y.5    Matsuda, T.6
  • 2
    • 0025102756 scopus 로고
    • Haemopoietic receptors and helical cytokines
    • Bazan JF. Haemopoietic receptors and helical cytokines. Immunol Today. 1990; 11: 350-354.
    • (1990) Immunol Today , vol.11 , pp. 350-354
    • Bazan, J.F.1
  • 3
    • 0023685762 scopus 로고
    • Cloning and expression of the human interleukin-6 (BSF-2/IFN beta 2) receptor
    • Yamasaki K, Taga T, Hirata Y, Yawata H, Kawanishi Y, Seed B, et al. Cloning and expression of the human interleukin-6 (BSF-2/IFN beta 2) receptor. Science. 1988; 241: 825-828.
    • (1988) Science , vol.241 , pp. 825-828
    • Yamasaki, K.1    Taga, T.2    Hirata, Y.3    Yawata, H.4    Kawanishi, Y.5    Seed, B.6
  • 4
    • 0025630163 scopus 로고
    • Molecular cloning and expression of an IL-6 signal transducer, gp130
    • Hibi M, Murakami M, Saito M, Hirano T, Taga T, Kishimoto T. Molecular cloning and expression of an IL-6 signal transducer, gp130. Cell. 1990; 63: 1149-1157.
    • (1990) Cell , vol.63 , pp. 1149-1157
    • Hibi, M.1    Murakami, M.2    Saito, M.3    Hirano, T.4    Taga, T.5    Kishimoto, T.6
  • 7
    • 0346157324 scopus 로고    scopus 로고
    • Acquiring signalling specificity from the cytokine receptor gp130
    • Ernst M, Jenkins BJ. Acquiring signalling specificity from the cytokine receptor gp130. Trends Genet. 2004; 20: 23-32.
    • (2004) Trends Genet , vol.20 , pp. 23-32
    • Ernst, M.1    Jenkins, B.J.2
  • 8
    • 59849091830 scopus 로고    scopus 로고
    • Therapeutic targeting of IL-6 trans-signaling counteracts STAT3 control of the inflammatory infiltrate in experimental arthritis
    • Nowell MA, Williams AS, Carty SA, Scheller J, Hayes AJ, Jones GW, et al. Therapeutic targeting of IL-6 trans-signaling counteracts STAT3 control of the inflammatory infiltrate in experimental arthritis. J Immunol. 2009; 182: 613-622.
    • (2009) J Immunol , vol.182 , pp. 613-622
    • Nowell, M.A.1    Williams, A.S.2    Carty, S.A.3    Scheller, J.4    Hayes, A.J.5    Jones, G.W.6
  • 9
    • 80052358980 scopus 로고    scopus 로고
    • Therapeutic strategies for the clinical blockade of IL-6/gp130 signaling
    • doi:10.1172/JCI57158
    • Jones SA, Scheller J, Rose-John S. Therapeutic strategies for the clinical blockade of IL-6/gp130 signaling. J Clin Invest. 2011; 121: 3375-3383. doi:10.1172/JCI57158.
    • (2011) J Clin Invest , vol.121 , pp. 3375-3383
    • Jones, S.A.1    Scheller, J.2    Rose-John, S.3
  • 10
    • 17644368573 scopus 로고    scopus 로고
    • Interleukin-6: From basic science to medicine--40 years in immunology
    • Kishimoto T. Interleukin-6: from basic science to medicine--40 years in immunology. Annu Rev Immunol 2005; 23: 1-21.
    • (2005) Annu Rev Immunol , vol.23 , pp. 1-21
    • Kishimoto, T.1
  • 11
    • 0035160256 scopus 로고    scopus 로고
    • Soluble gp130 is the natural inhibitor of soluble IL-6R transsignaling responses
    • Jostock T, Müllberg J, Özbek S, Atreya R, Blinn G, Voltz N, et al. Soluble gp130 is the natural inhibitor of soluble IL-6R transsignaling responses. Eur J Biochem. 2001; 268: 160-167.
    • (2001) Eur J Biochem , vol.268 , pp. 160-167
    • Jostock, T.1    Müllberg, J.2    Özbek, S.3    Atreya, R.4    Blinn, G.5    Voltz, N.6
  • 13
    • 0024458160 scopus 로고
    • Soluble cytokine receptors are present in normal human urine
    • Novick D, Engelmann H, Wallach D, Rubinstein M. Soluble cytokine receptors are present in normal human urine. J Exp Med. 1989; 170: 1409-1414.
    • (1989) J Exp Med , vol.170 , pp. 1409-1414
    • Novick, D.1    Engelmann, H.2    Wallach, D.3    Rubinstein, M.4
  • 17
    • 79960923986 scopus 로고    scopus 로고
    • ADAM17: A molecular switch of inflammatory and regenerative responses?
    • Scheller J, Chalaris A, Garbers C, Rose-John S. ADAM17: a molecular switch of inflammatory and regenerative responses? Trends Immunol. 2011; 32: 380-387.
    • (2011) Trends Immunol , vol.32 , pp. 380-387
    • Scheller, J.1    Chalaris, A.2    Garbers, C.3    Rose-John, S.4
  • 18
    • 0028226196 scopus 로고
    • Soluble receptors for cytokines and growth factors: Generation and biological function
    • Rose-John S, Heinrich PC. Soluble receptors for cytokines and growth factors: generation and biological function. Biochem J. 1994; 300: 281-290.
    • (1994) Biochem J , vol.300 , pp. 281-290
    • Rose-John, S.1    Heinrich, P.C.2
  • 19
    • 0024393839 scopus 로고
    • Interleukin-6 triggers the association of its receptor with a possible signal transducer, gp130
    • Taga T, Hibi M, Hirata Y, Yamasaki K, Yasukawa K, Matsuda T, et al. Interleukin-6 triggers the association of its receptor with a possible signal transducer, gp130. Cell. 1989; 58: 573-581.
    • (1989) Cell , vol.58 , pp. 573-581
    • Taga, T.1    Hibi, M.2    Hirata, Y.3    Yamasaki, K.4    Yasukawa, K.5    Matsuda, T.6
  • 21
    • 0028270409 scopus 로고
    • The soluble human IL-6 receptor. Mutational characterization of the proteolytic cleavage site
    • Müllberg J, Oberthur W, Lottspeich F, Mehl E, Dittrich E, Graeve L, et al. The soluble human IL-6 receptor. Mutational characterization of the proteolytic cleavage site. J Immunol. 1994; 152: 4958-4968.
    • (1994) J Immunol , vol.152 , pp. 4958-4968
    • Müllberg, J.1    Oberthur, W.2    Lottspeich, F.3    Mehl, E.4    Dittrich, E.5    Graeve, L.6
  • 23
    • 0029795014 scopus 로고    scopus 로고
    • Pore-forming toxins trigger shedding of receptors for interleukin 6 and lipopolysaccharide
    • Walev I, Vollmer P, Palmer M, Bhakdi S, Rose-John S. Pore-forming toxins trigger shedding of receptors for interleukin 6 and lipopolysaccharide. Proc Natl Acad Sci USA. 1996; 93: 7882-7887.
    • (1996) Proc Natl Acad Sci USA , vol.93 , pp. 7882-7887
    • Walev, I.1    Vollmer, P.2    Palmer, M.3    Bhakdi, S.4    Rose-John, S.5
  • 24
    • 0141866756 scopus 로고    scopus 로고
    • Cholesterol depletion of the plasma membrane triggers shedding of the human interleukin-6 receptor by TACE and independently of PKC
    • Matthews V, Schuster B, Schütze S, Kallen K-J, Rose-John S. Cholesterol depletion of the plasma membrane triggers shedding of the human interleukin-6 receptor by TACE and independently of PKC. J Biol Chem. 2003; 278: 38829-38839.
    • (2003) J Biol Chem , vol.278 , pp. 38829-38839
    • Matthews, V.1    Schuster, B.2    Schütze, S.3    Kallen, K.-J.4    Rose-John, S.5
  • 25
    • 0029736417 scopus 로고    scopus 로고
    • Novel pathogenic mechanism of microbial metalloproteinases: Liberation of membrane-anchored molecules in biologically active form exemplified by studies with the human interleukin-6 receptor
    • Vollmer P, Walev I, Rose-John S, Bhakdi S. Novel pathogenic mechanism of microbial metalloproteinases: liberation of membrane-anchored molecules in biologically active form exemplified by studies with the human interleukin-6 receptor. Infect Immun. 1996; 64: 3646-3651.
    • (1996) Infect Immun , vol.64 , pp. 3646-3651
    • Vollmer, P.1    Walev, I.2    Rose-John, S.3    Bhakdi, S.4
  • 26
    • 34548856204 scopus 로고    scopus 로고
    • Apoptosis is a natural stimulus of IL6R shedding and contributes to the pro-inflammatory trans-signaling function of neutrophils
    • Chalaris A, Rabe B, Paliga K, Lange H, Laskay T, Fielding CA, et al. Apoptosis is a natural stimulus of IL6R shedding and contributes to the pro-inflammatory trans-signaling function of neutrophils. Blood. 2007; 110: 1748-1755.
    • (2007) Blood , vol.110 , pp. 1748-1755
    • Chalaris, A.1    Rabe, B.2    Paliga, K.3    Lange, H.4    Laskay, T.5    Fielding, C.A.6
  • 27
    • 34548844436 scopus 로고    scopus 로고
    • Attractive shedding
    • DeLeo FR. Attractive shedding. Blood. 2007; 110: 1711-1712.
    • (2007) Blood , vol.110 , pp. 1711-1712
    • Deleo, F.R.1
  • 28
    • 33646577466 scopus 로고    scopus 로고
    • Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells
    • Bettelli E, Carrier Y, Gao W, Korn T, Strom TB, Oukka M, et al. Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells. Nature. 2006; 441: 235-238.
    • (2006) Nature , vol.441 , pp. 235-238
    • Bettelli, E.1    Carrier, Y.2    Gao, W.3    Korn, T.4    Strom, T.B.5    Oukka, M.6
  • 29
    • 34848876937 scopus 로고    scopus 로고
    • Cutting edge: Trans-signaling via the soluble IL-6R abrogates the induction of FoxP3 in naive CD4+CD25 T cells
    • Dominitzki S, Fantini MC, Neufert C, Nikolaev A, Galle PR, Scheller J, et al. Cutting edge: trans-signaling via the soluble IL-6R abrogates the induction of FoxP3 in naive CD4+CD25 T cells. J Immunol. 2007; 179: 2041-2045.
    • (2007) J Immunol , vol.179 , pp. 2041-2045
    • Dominitzki, S.1    Fantini, M.C.2    Neufert, C.3    Nikolaev, A.4    Galle, P.R.5    Scheller, J.6
  • 30
    • 47249089967 scopus 로고    scopus 로고
    • Cutting Edge: Soluble IL-6R Is Produced by IL-6R Ectodomain Shedding in Activated CD4 T Cells
    • Briso EM, Dienz O, Rincon M. Cutting Edge: Soluble IL-6R Is Produced by IL-6R Ectodomain Shedding in Activated CD4 T Cells. J Immunol. 2008; 180: 7102-7126.
    • (2008) J Immunol , vol.180 , pp. 7102-7126
    • Briso, E.M.1    Dienz, O.2    Rincon, M.3
  • 31
    • 77949881389 scopus 로고    scopus 로고
    • Loss of CD4+ T cell IL-6R expression during inflammation underlines a role for IL-6 trans signaling in the local maintenance of Th17 cells
    • Jones GW, McLoughlin RM, Hammond VJ, Parker CR, Williams JD, Malhotra R, et al. Loss of CD4+ T cell IL-6R expression during inflammation underlines a role for IL-6 trans signaling in the local maintenance of Th17 cells. J Immunol. 2010; 184: 2130-2139.
    • (2010) J Immunol , vol.184 , pp. 2130-2139
    • Jones, G.W.1    McLoughlin, R.M.2    Hammond, V.J.3    Parker, C.R.4    Williams, J.D.5    Malhotra, R.6
  • 32
    • 0027293104 scopus 로고
    • Soluble forms of the interleukin-6 signal-transducing receptor component gp130 in human serum possessing a potential to inhibit signals through membrane-anchored gp130
    • Narazaki M, Yasukawa K, Saito T, Ohsugi Y, Fukui H, Koishihara Y, et al. Soluble forms of the interleukin-6 signal-transducing receptor component gp130 in human serum possessing a potential to inhibit signals through membrane-anchored gp130. Blood. 1993; 82: 1120-1126.
    • (1993) Blood , vol.82 , pp. 1120-1126
    • Narazaki, M.1    Yasukawa, K.2    Saito, T.3    Ohsugi, Y.4    Fukui, H.5    Koishihara, Y.6
  • 33
    • 0032562601 scopus 로고    scopus 로고
    • Identification and characterization of two distinct truncated forms of gp130 and a soluble form of leukemia inhibitory factor receptor alpha-chain in normal human urine and plasma
    • Zhang JG, Zhang Y, Owczarek CM, Ward LD, Moritz RL, Simpson RJ, et al. Identification and characterization of two distinct truncated forms of gp130 and a soluble form of leukemia inhibitory factor receptor alpha-chain in normal human urine and plasma. J Biol Chem. 1998; 273: 10798-10805.
    • (1998) J Biol Chem , vol.273 , pp. 10798-10805
    • Zhang, J.G.1    Zhang, Y.2    Owczarek, C.M.3    Ward, L.D.4    Moritz, R.L.5    Simpson, R.J.6
  • 34
    • 33646469222 scopus 로고    scopus 로고
    • Functional characterization of a soluble gp130 isoform and its therapeutic capacity in an experimental model of inflammatory arthritis
    • Richards PJ, Nowell MA, Horiuchi S, McLoughlin RM, Fielding CA, Grau S, et al. Functional characterization of a soluble gp130 isoform and its therapeutic capacity in an experimental model of inflammatory arthritis. Arthr Rheumat. 2006; 54: 1662-1672.
    • (2006) Arthr Rheumat , vol.54 , pp. 1662-1672
    • Richards, P.J.1    Nowell, M.A.2    Horiuchi, S.3    McLoughlin, R.M.4    Fielding, C.A.5    Grau, S.6
  • 36
    • 0029950150 scopus 로고    scopus 로고
    • Differential interleukin-6 (IL-6) responses of three established myeloma cell lines in the presence of soluble human IL-6 receptors
    • Diamant M, Hansen MB, Rieneck K, Svenson M, Yasukawa K, Bendtzen K. Differential interleukin-6 (IL-6) responses of three established myeloma cell lines in the presence of soluble human IL-6 receptors. Leuk Res. 1996; 20: 291-301.
    • (1996) Leuk Res , vol.20 , pp. 291-301
    • Diamant, M.1    Hansen, M.B.2    Rieneck, K.3    Svenson, M.4    Yasukawa, K.5    Bendtzen, K.6
  • 37
    • 0029863504 scopus 로고    scopus 로고
    • The function of the soluble interleukin 6 (IL-6) receptor in vivo: Sensitization of human soluble IL-6 receptor transgenic mice towards IL-6 and prolongation of the plasma half-life of IL-6
    • Peters M, Jacobs S, Ehlers M, Vollmer P, Müllberg J, Wolf E, et al. The function of the soluble interleukin 6 (IL-6) receptor in vivo: sensitization of human soluble IL-6 receptor transgenic mice towards IL-6 and prolongation of the plasma half-life of IL-6. J Exp Med. 1996; 183: 1399-1406.
    • (1996) J Exp Med , vol.183 , pp. 1399-1406
    • Peters, M.1    Jacobs, S.2    Ehlers, M.3    Vollmer, P.4    Müllberg, J.5    Wolf, E.6
  • 38
    • 0027303256 scopus 로고
    • Structure-function analysis of interleukin-6 utilizing human/murine chimeric molecules. Involvement of two separate domains in receptor binding
    • van Dam M, Müllberg J, Schooltink H, Stoyan T, Brakenhoff JP, Graeve L, et al. Structure-function analysis of interleukin-6 utilizing human/murine chimeric molecules. Involvement of two separate domains in receptor binding. J Biol Chem. 1993; 268: 15285-15290.
    • (1993) J Biol Chem , vol.268 , pp. 15285-15290
    • van Dam, M.1    Müllberg, J.2    Schooltink, H.3    Stoyan, T.4    Brakenhoff, J.P.5    Graeve, L.6
  • 39
    • 0028331014 scopus 로고
    • Development of progressive kidney damage and myeloma kidney in interleukin-6 transgenic mice
    • Fattori E, Della Rocca C, Costa P, Giorgio M, Dente B, Pozzi L, et al. Development of progressive kidney damage and myeloma kidney in interleukin-6 transgenic mice. Blood. 1994; 83: 2570-2579.
    • (1994) Blood , vol.83 , pp. 2570-2579
    • Fattori, E.1    della Rocca, C.2    Costa, P.3    Giorgio, M.4    Dente, B.5    Pozzi, L.6
  • 40
    • 18244419398 scopus 로고    scopus 로고
    • Extramedullary expansion of hematopoietic progenitor cells in IL-6/sIL-6R double transgenic mice
    • Peters M, Schirmacher P, Goldschmitt J, Odenthal M, Peschel C, Dienes HP, et al. Extramedullary expansion of hematopoietic progenitor cells in IL-6/sIL-6R double transgenic mice. J Exp Med. 1997; 185: 755-766.
    • (1997) J Exp Med , vol.185 , pp. 755-766
    • Peters, M.1    Schirmacher, P.2    Goldschmitt, J.3    Odenthal, M.4    Peschel, C.5    Dienes, H.P.6
  • 41
    • 0031858640 scopus 로고    scopus 로고
    • Hepatocellular Hyperplasia, Plasmacytoma Formation, and Extracellular Hematopoiesis in Interleukin (IL)-6/Soluble IL-6 Receptor Double-Transgenic Mice
    • Schirmacher P, Peters M, Ciliberto G, Fattori E, Lotz J, Meyer zum Büschenfelde KH, et al. Hepatocellular Hyperplasia, Plasmacytoma Formation, and Extracellular Hematopoiesis in Interleukin (IL)-6/Soluble IL-6 Receptor Double-Transgenic Mice. Am J Pathol. 1998; 153: 639-648.
    • (1998) Am J Pathol , vol.153 , pp. 639-648
    • Schirmacher, P.1    Peters, M.2    Ciliberto, G.3    Fattori, E.4    Lotz, J.5    Meyer zum Büschenfelde, K.H.6
  • 42
    • 0032190524 scopus 로고    scopus 로고
    • Coexpression of IL-6 and soluble IL-6R causes nodular regenerative hyperplasia and adenomas of the liver
    • Maione D, Di Carlo E, Li W, Musiani P, Modesti A, Peters M, et al. Coexpression of IL-6 and soluble IL-6R causes nodular regenerative hyperplasia and adenomas of the liver. Embo J. 1998; 17: 5588-5597.
    • (1998) Embo J , vol.17 , pp. 5588-5597
    • Maione, D.1    Di Carlo, E.2    Li, W.3    Musiani, P.4    Modesti, A.5    Peters, M.6
  • 43
    • 0032533949 scopus 로고    scopus 로고
    • Interleukin-6 and soluble Interleukin-6 Receptor: Direct Stimulation of gp130 and Hematopoiesis
    • Peters M, Müller A, Rose-John S. Interleukin-6 and soluble Interleukin-6 Receptor: Direct Stimulation of gp130 and Hematopoiesis. Blood. 1998; 92: 3495-3504.
    • (1998) Blood , vol.92 , pp. 3495-3504
    • Peters, M.1    Müller, A.2    Rose-John, S.3
  • 44
    • 0028305730 scopus 로고
    • Identification of a region within the cytoplasmic domain of the interleukin-6 (IL-6) signal transducer gp130 important for ligand-induced endocytosis of the IL-6 receptor
    • Dittrich E, Rose-John S, Gerhartz C, Mullberg J, Stoyan T, Yasukawa K, et al. Identification of a region within the cytoplasmic domain of the interleukin-6 (IL-6) signal transducer gp130 important for ligand-induced endocytosis of the IL-6 receptor. J Biol Chem. 1994; 269: 19014-19020.
    • (1994) J Biol Chem , vol.269 , pp. 19014-19020
    • Dittrich, E.1    Rose-John, S.2    Gerhartz, C.3    Mullberg, J.4    Stoyan, T.5    Yasukawa, K.6
  • 46
    • 0025303609 scopus 로고
    • Studies on the structure and regulation of the human hepatic interleukin-6 receptor
    • Rose-John S, Schooltink H, Lenz D, Hipp E, Dufhues G, Schmitz H, et al. Studies on the structure and regulation of the human hepatic interleukin-6 receptor. Eur J Biochem. 1990; 190: 79-83.
    • (1990) Eur J Biochem , vol.190 , pp. 79-83
    • Rose-John, S.1    Schooltink, H.2    Lenz, D.3    Hipp, E.4    Dufhues, G.5    Schmitz, H.6
  • 47
    • 0035852678 scopus 로고    scopus 로고
    • Distinct role of gp130 activation in promoting self-renewal divisions by mitogenically stimulated murine hematopoietic cells
    • Audet J, Miller CL, Rose-John S, Piret JM, Eaves CJ. Distinct role of gp130 activation in promoting self-renewal divisions by mitogenically stimulated murine hematopoietic cells. Proc Natl Acad Sci USA. 2001; 98: 1757-1762.
    • (2001) Proc Natl Acad Sci USA , vol.98 , pp. 1757-1762
    • Audet, J.1    Miller, C.L.2    Rose-John, S.3    Piret, J.M.4    Eaves, C.J.5
  • 49
    • 0345104338 scopus 로고    scopus 로고
    • Role of Interleukin-6 and soluble IL-6 Receptor in Region Specific Induction of Astrocytic Differentiation and Neurotrophin Expression
    • März P, Heese K, Dimitriades-Schmutz B, Rose-John S, Otten U. Role of Interleukin-6 and soluble IL-6 Receptor in Region Specific Induction of Astrocytic Differentiation and Neurotrophin Expression. Glia. 1999; 26: 191-200.
    • (1999) Glia , vol.26 , pp. 191-200
    • März, P.1    Heese, K.2    Dimitriades-Schmutz, B.3    Rose-John, S.4    Otten, U.5
  • 50
    • 0032846613 scopus 로고    scopus 로고
    • Novel Path of activation of primary human smooth muscle cells: Upregulation of gp130 creates an autocrine activation loop by IL-6 and its soluble receptor
    • Klouche M, Bhakdi S, Hemmes M, Rose-John S. Novel Path of activation of primary human smooth muscle cells: upregulation of gp130 creates an autocrine activation loop by IL-6 and its soluble receptor. J Immunol. 1999; 163: 4583-4589.
    • (1999) J Immunol , vol.163 , pp. 4583-4589
    • Klouche, M.1    Bhakdi, S.2    Hemmes, M.3    Rose-John, S.4
  • 51
    • 0036219910 scopus 로고    scopus 로고
    • Ligand/receptor signaling threshold (LIST) model accounts for gp130-mediated embryonic stem cell self-renewal responses to LIF and HIL-6
    • Viswanathan S, Benatar T, Rose-John S, Lauffenburger DA, Zandstra PW. Ligand/receptor signaling threshold (LIST) model accounts for gp130-mediated embryonic stem cell self-renewal responses to LIF and HIL-6. Stem cells (Dayton, Ohio). 2002; 20: 119-138.
    • (2002) Stem Cells (Dayton, Ohio) , vol.20 , pp. 119-138
    • Viswanathan, S.1    Benatar, T.2    Rose-John, S.3    Lauffenburger, D.A.4    Zandstra, P.W.5
  • 53
    • 33748848714 scopus 로고    scopus 로고
    • Interleukin-6 Biology is Coordinated by Membrane-Bound and Soluble Receptors: Role in Inflammation and Cancer
    • Rose-John S, Scheller J, Elson G, Jones S. Interleukin-6 Biology is Coordinated by Membrane-Bound and Soluble Receptors: Role in Inflammation and Cancer. J Leuk Biol. 2006; 80: 227-236.
    • (2006) J Leuk Biol , vol.80 , pp. 227-236
    • Rose-John, S.1    Scheller, J.2    Elson, G.3    Jones, S.4
  • 55
    • 84857411475 scopus 로고    scopus 로고
    • Hitting a complex target: An update on interleukin-6 trans-signalling
    • Waetzig GH, Rose-John S. Hitting a complex target: an update on interleukin-6 trans-signalling. Expert Opin Ther Targets. 2012; 16: 225-236.
    • (2012) Expert Opin Ther Targets , vol.16 , pp. 225-236
    • Waetzig, G.H.1    Rose-John, S.2
  • 59
    • 33745598848 scopus 로고    scopus 로고
    • Forced dimerization of gp130 leads to constitutive STAT3 activation, cytokine independent growth and blockade of differentiation of embryonic stem cells
    • Stuhlmann-Laeisz C, Lang S, Chalaris A, Paliga K, Sudarman E, Eichler J, et al. Forced dimerization of gp130 leads to constitutive STAT3 activation, cytokine independent growth and blockade of differentiation of embryonic stem cells. Mol Biol Cell. 2006; 17: 2986-2995.
    • (2006) Mol Biol Cell , vol.17 , pp. 2986-2995
    • Stuhlmann-Laeisz, C.1    Lang, S.2    Chalaris, A.3    Paliga, K.4    Sudarman, E.5    Eichler, J.6
  • 60
    • 77955106518 scopus 로고    scopus 로고
    • Forced homo- and heterodimerization of all gp130-type receptor complexes leads to constitutive ligand-independent signaling and cytokine-independent growth
    • Suthaus J, Tillmann A, Lorenzen I, Bulanova E, Rose-John S, Scheller J. Forced homo- and heterodimerization of all gp130-type receptor complexes leads to constitutive ligand-independent signaling and cytokine-independent growth. Mol Biol Cell. 2010; 21: 2797-2807.
    • (2010) Mol Biol Cell , vol.21 , pp. 2797-2807
    • Suthaus, J.1    Tillmann, A.2    Lorenzen, I.3    Bulanova, E.4    Rose-John, S.5    Scheller, J.6
  • 61
    • 0037434888 scopus 로고    scopus 로고
    • The human interleukin-6 (IL-6) receptor exists as a preformed dimer in the plasma membrane
    • Schuster B, Meinert W, Rose-John S, Kallen K-J. The human interleukin-6 (IL-6) receptor exists as a preformed dimer in the plasma membrane. FEBS Lett. 2003; 538: 113-116.
    • (2003) FEBS Lett , vol.538 , pp. 113-116
    • Schuster, B.1    Meinert, W.2    Rose-John, S.3    Kallen, K.-J.4
  • 63
    • 0024529891 scopus 로고
    • The complex pattern of cytokines in serum from patients with meningococcal septic shock
    • Waage A, Brandtzaeg P, Halstensen A, Kierulf P, Espevik T. The complex pattern of cytokines in serum from patients with meningococcal septic shock. J Exp Med. 1989; 169: 333-338.
    • (1989) J Exp Med , vol.169 , pp. 333-338
    • Waage, A.1    Brandtzaeg, P.2    Halstensen, A.3    Kierulf, P.4    Espevik, T.5
  • 64
    • 0042834261 scopus 로고    scopus 로고
    • Soluble IL-6 Receptor Governs IL-6 Activity in Experimental Arthritis: Blockade of Arthritis Severity by Soluble Glycoprotein 130
    • Nowell MA, Richards PJ, Horiuchi S, Yamamoto N, Rose-John S, Topley N, et al. Soluble IL-6 Receptor Governs IL-6 Activity in Experimental Arthritis: Blockade of Arthritis Severity by Soluble Glycoprotein 130. J Immunol. 2003; 171: 3202-3209.
    • (2003) J Immunol , vol.171 , pp. 3202-3209
    • Nowell, M.A.1    Richards, P.J.2    Horiuchi, S.3    Yamamoto, N.4    Rose-John, S.5    Topley, N.6
  • 65
    • 0026554229 scopus 로고
    • Human soluble IL-6 receptor: Its detection and enhanced release by HIV infection
    • Honda M, Yamamoto S, Cheng M, Yasukawa K, Suzuki H, Saito T, et al. Human soluble IL-6 receptor: its detection and enhanced release by HIV infection. J Immunol. 1992; 148: 2175-2180.
    • (1992) J Immunol , vol.148 , pp. 2175-2180
    • Honda, M.1    Yamamoto, S.2    Cheng, M.3    Yasukawa, K.4    Suzuki, H.5    Saito, T.6
  • 66
    • 0032731374 scopus 로고    scopus 로고
    • CSF and serum levels of soluble interleukin-6 receptors (sIL-6R and sgp130), but not of interleukin-6 are altered in multiple sclerosis
    • Padberg F, Feneberg W, Schmidt S, Schwarz MJ, Korschenhausen D, Greenberg BD, et al. CSF and serum levels of soluble interleukin-6 receptors (sIL-6R and sgp130), but not of interleukin-6 are altered in multiple sclerosis. J Neuroimmunol. 1999; 99: 218-223.
    • (1999) J Neuroimmunol , vol.99 , pp. 218-223
    • Padberg, F.1    Feneberg, W.2    Schmidt, S.3    Schwarz, M.J.4    Korschenhausen, D.5    Greenberg, B.D.6
  • 67
    • 20144375594 scopus 로고    scopus 로고
    • The IL-6R alpha chain controls lung CD4+CD4+CD25+T regulatory cell development and function during allergic airway inflammation in vivo
    • Doganci A, Eigenbrod T, Krug N, De Sanctis GT, Hausding M, Erpenbeck VJ, et al. The IL-6R alpha chain controls lung CD4+CD4+CD25+T regulatory cell development and function during allergic airway inflammation in vivo. J Clin Invest. 2005; 115: 313-325.
    • (2005) J Clin Invest , vol.115 , pp. 313-325
    • Doganci, A.1    Eigenbrod, T.2    Krug, N.3    de Sanctis, G.T.4    Hausding, M.5    Erpenbeck, V.J.6
  • 70
    • 83355163340 scopus 로고    scopus 로고
    • Inhibition of classic signaling is a novel function of soluble glycoprotein 130 (sgp130), which is controlled by the ratio of interleukin 6 and soluble interleukin 6 receptor
    • Garbers C, Thaiss W, Jones GW, Waetzig GH, Lorenzen I, Guilhot F, et al. Inhibition of classic signaling is a novel function of soluble glycoprotein 130 (sgp130), which is controlled by the ratio of interleukin 6 and soluble interleukin 6 receptor. J Biol Chem. 2011; 286: 42959-42970.
    • (2011) J Biol Chem , vol.286 , pp. 42959-42970
    • Garbers, C.1    Thaiss, W.2    Jones, G.W.3    Waetzig, G.H.4    Lorenzen, I.5    Guilhot, F.6
  • 71
    • 84859210770 scopus 로고    scopus 로고
    • Interleukin-6 receptor pathways in coronary heart disease: A collaborative meta-analysis of 82 studies
    • Sarwar N, Butterworth AS, Freitag DF, Gregson J, Willeit P, Gorman DN, et al. Interleukin-6 receptor pathways in coronary heart disease: a collaborative meta-analysis of 82 studies. Lancet. 2012; 379: 1205-1213.
    • (2012) Lancet , vol.379 , pp. 1205-1213
    • Sarwar, N.1    Butterworth, A.S.2    Freitag, D.F.3    Gregson, J.4    Willeit, P.5    Gorman, D.N.6
  • 72
    • 84859215358 scopus 로고    scopus 로고
    • The interleukin-6 receptor as a target for prevention of coronary heart disease: A mendelian randomisation analysis
    • Hingorani AD, Casas JP. The interleukin-6 receptor as a target for prevention of coronary heart disease: a mendelian randomisation analysis. Lancet. 2012; 379: 1214-1224.
    • (2012) Lancet , vol.379 , pp. 1214-1224
    • Hingorani, A.D.1    Casas, J.P.2
  • 73
    • 84859218984 scopus 로고    scopus 로고
    • The interleukin-6 pathway and atherosclerosis
    • Boekholdt SM, Stroes ES. The interleukin-6 pathway and atherosclerosis. Lancet. 2012; 379: 1176-118.
    • (2012) Lancet , vol.379 , pp. 1176-1178
    • Boekholdt, S.M.1    Stroes, E.S.2
  • 74
    • 84864229482 scopus 로고    scopus 로고
    • The interleukin 6 pathway and atherosclerosis
    • Scheller J, Rose-John S. The interleukin 6 pathway and atherosclerosis. Lancet. 2012; 380: 338.
    • (2012) Lancet , vol.380 , pp. 338
    • Scheller, J.1    Rose-John, S.2
  • 75
    • 84865377662 scopus 로고    scopus 로고
    • Therapeutic targeting of interleukin-6 trans-signaling does not affect the outcome of experimental tuberculosis
    • in press
    • Sodenkamp J, Waetzig GH, Scheller J, Seegert D, Grotzinger J, Rose-John S, et al. Therapeutic targeting of interleukin-6 trans-signaling does not affect the outcome of experimental tuberculosis. Immunobiology. 2012, in press
    • (2012) Immunobiology
    • Sodenkamp, J.1    Waetzig, G.H.2    Scheller, J.3    Seegert, D.4    Grotzinger, J.5    Rose-John, S.6
  • 76
    • 58649108302 scopus 로고    scopus 로고
    • IL-6 and STAT3 signaling is required for survival of intestinal epithelial cells and colitis associated cancer
    • Grivennikov S, Karin E, Terzic J, Mucida D, Yu G-Y, Vallabhapurapu S, et al. IL-6 and STAT3 signaling is required for survival of intestinal epithelial cells and colitis associated cancer. Cancer Cell. 2009; 16: 103-113.
    • (2009) Cancer Cell , vol.16 , pp. 103-113
    • Grivennikov, S.1    Karin, E.2    Terzic, J.3    Mucida, D.4    Yu, G.-Y.5    Vallabhapurapu, S.6
  • 77
    • 45549097533 scopus 로고    scopus 로고
    • IL-6-dependent mucosal protection prevents establishment of a microbial niche for attaching/effacing lesion-forming enteric bacterial pathogens
    • Dann SM, Spehlmann ME, Hammond DC, Iimura M, Hase K, Choi LJ, et al. IL-6-dependent mucosal protection prevents establishment of a microbial niche for attaching/effacing lesion-forming enteric bacterial pathogens. J Immunol. 2008; 180: 6816-6826.
    • (2008) J Immunol , vol.180 , pp. 6816-6826
    • Dann, S.M.1    Spehlmann, M.E.2    Hammond, D.C.3    Iimura, M.4    Hase, K.5    Choi, L.J.6
  • 78
    • 5644252874 scopus 로고    scopus 로고
    • TGF-beta suppresses tumor progression in colon cancer by inhibition of IL-6 trans-signaling
    • Becker C, Fantini MC, Schramm C, Lehr HA, Wirtz S, Nikolaev A, et al. TGF-beta suppresses tumor progression in colon cancer by inhibition of IL-6 trans-signaling. Immunity. 2004; 21: 491-501.
    • (2004) Immunity , vol.21 , pp. 491-501
    • Becker, C.1    Fantini, M.C.2    Schramm, C.3    Lehr, H.A.4    Wirtz, S.5    Nikolaev, A.6
  • 79
    • 79957656408 scopus 로고    scopus 로고
    • Selective blockade of interleukin-6 trans-signaling improves survival in a murine polymicrobial sepsis model
    • Barkhausen T, Tschernig T, Rosenstiel P, van Griensven M, Vonberg RP, Dorsch M, et al. Selective blockade of interleukin-6 trans-signaling improves survival in a murine polymicrobial sepsis model. Crit Care Med. 2011; 39: 1407-1413.
    • (2011) Crit Care Med , vol.39 , pp. 1407-1413
    • Barkhausen, T.1    Tschernig, T.2    Rosenstiel, P.3    van Griensven, M.4    Vonberg, R.P.5    Dorsch, M.6
  • 80
    • 77649271394 scopus 로고    scopus 로고
    • ADAM17-mediated shedding of the IL6R induces cleavage of the membrane stub by gamma-secretase
    • Chalaris A, Gewiese J, Paliga K, Fleig L, Schneede A, Krieger K, et al. ADAM17-mediated shedding of the IL6R induces cleavage of the membrane stub by gamma-secretase. Biochim Biophys Acta. 2010; 1803: 234-245.
    • (2010) Biochim Biophys Acta , vol.1803 , pp. 234-245
    • Chalaris, A.1    Gewiese, J.2    Paliga, K.3    Fleig, L.4    Schneede, A.5    Krieger, K.6
  • 82
    • 0030852894 scopus 로고    scopus 로고
    • A Kaposi's Sarcoma-associated Herpesvirus-encoded Cytokine Homolog (vIL-6) Activates Signaling through the Shared gp130 Receptor Subunit
    • Molden J, Chang Y, You Y, Moore PS, Goldsmith MA. A Kaposi's Sarcoma-associated Herpesvirus-encoded Cytokine Homolog (vIL-6) Activates Signaling through the Shared gp130 Receptor Subunit. J Biol Chem. 1997; 272: 19625-19631.
    • (1997) J Biol Chem , vol.272 , pp. 19625-19631
    • Molden, J.1    Chang, Y.2    You, Y.3    Moore, P.S.4    Goldsmith, M.A.5
  • 84
    • 0001640974 scopus 로고    scopus 로고
    • Human herpes virus 8 interleukin-6 homologue triggers gp130 on neuronal and hematopoietic cells
    • Hoischen SH, Vollmer P, Marz P, Ozbek S, Gotze KS, Peschel C, et al. Human herpes virus 8 interleukin-6 homologue triggers gp130 on neuronal and hematopoietic cells. Eur J Biochem/FEBS J. 2000; 267: 3604-3612.
    • (2000) Eur J Biochem/FEBS J , vol.267 , pp. 3604-3612
    • Hoischen, S.H.1    Vollmer, P.2    Marz, P.3    Ozbek, S.4    Gotze, K.S.5    Peschel, C.6
  • 85
    • 0035896394 scopus 로고    scopus 로고
    • Structure of an extracellular gp130 cytokine receptor signaling complex
    • Chow D, He X, Snow AL, Rose-John S, Garcia KC. Structure of an extracellular gp130 cytokine receptor signaling complex. Science. 2001; 291: 2150-2155.
    • (2001) Science , vol.291 , pp. 2150-2155
    • Chow, D.1    He, X.2    Snow, A.L.3    Rose-John, S.4    Garcia, K.C.5
  • 86
    • 65349181345 scopus 로고    scopus 로고
    • Unraveling viral interleukin-6 binding to gp130 and activation of STAT-signaling pathways independently of the interleukin-6 receptor
    • Adam N, Rabe B, Suthaus J, Grotzinger J, Rose-John S, Scheller J. Unraveling viral interleukin-6 binding to gp130 and activation of STAT-signaling pathways independently of the interleukin-6 receptor. J Virol. 2009; 83: 5117-5126.
    • (2009) J Virol , vol.83 , pp. 5117-5126
    • Adam, N.1    Rabe, B.2    Suthaus, J.3    Grotzinger, J.4    Rose-John, S.5    Scheller, J.6
  • 87
    • 33748653151 scopus 로고    scopus 로고
    • Abrogation of viral interleukin-6 (vIL-6)-induced signaling by intracellular retention and neutralization of vIL-6 with an anti-vIL-6 single-chain antibody selected by phage display
    • Kovaleva M, Bussmeyer I, Rabe B, Grotzinger J, Sudarman E, Eichler J, et al. Abrogation of viral interleukin-6 (vIL-6)-induced signaling by intracellular retention and neutralization of vIL-6 with an anti-vIL-6 single-chain antibody selected by phage display. J Virol. 2006; 80: 8510-8520.
    • (2006) J Virol , vol.80 , pp. 8510-8520
    • Kovaleva, M.1    Bussmeyer, I.2    Rabe, B.3    Grotzinger, J.4    Sudarman, E.5    Eichler, J.6
  • 88
    • 10644253485 scopus 로고    scopus 로고
    • Kaposi's sarcoma-associated herpesvirus-encoded viral interleukin-6 is secreted and modified differently than human interleukin-6: Evidence for a unique autocrine signaling mechanism
    • Meads MB, Medveczky PG. Kaposi's sarcoma-associated herpesvirus-encoded viral interleukin-6 is secreted and modified differently than human interleukin-6: evidence for a unique autocrine signaling mechanism. J Biol Chem. 2004; 279: 51793-51803.
    • (2004) J Biol Chem , vol.279 , pp. 51793-51803
    • Meads, M.B.1    Medveczky, P.G.2
  • 89
    • 0037165909 scopus 로고    scopus 로고
    • Human herpesvirus 8-derived viral IL-6 induces PTX3 expression in Kaposi's sarcoma cells
    • Klouche M, Brockmeyer N, Knabbe C, Rose-John S. Human herpesvirus 8-derived viral IL-6 induces PTX3 expression in Kaposi's sarcoma cells. Aids. 2002; 16: F9-18.
    • (2002) Aids , vol.16
    • Klouche, M.1    Brockmeyer, N.2    Knabbe, C.3    Rose-John, S.4
  • 90
    • 14944366493 scopus 로고    scopus 로고
    • Virokines in the pathogenesis of cancer: Focus on human herpesvirus 8
    • Klouche M, Carruba G, Castagnetta L, Rose-John S. Virokines in the pathogenesis of cancer: focus on human herpesvirus 8. Ann N Y Acad Sci. 2004; 1028: 329-339.
    • (2004) Ann N Y Acad Sci , vol.1028 , pp. 329-339
    • Klouche, M.1    Carruba, G.2    Castagnetta, L.3    Rose-John, S.4
  • 91
    • 79955482665 scopus 로고    scopus 로고
    • Viral Interleukin-6: Structure, pathophysiology and strategies of neutralization
    • Suthaus J, Adam N, Grotzinger J, Scheller J, Rose-John S. Viral Interleukin-6: Structure, pathophysiology and strategies of neutralization. Eur J Cell Biol. 2011; 90: 495-504.
    • (2011) Eur J Cell Biol , vol.90 , pp. 495-504
    • Suthaus, J.1    Adam, N.2    Grotzinger, J.3    Scheller, J.4    Rose-John, S.5
  • 93
    • 84861851475 scopus 로고    scopus 로고
    • HHV-8-encoded viral IL-6 collaborates with mouse IL-6 in the development of multicentric Castleman disease in mice
    • Suthaus J, Stuhlmann-Laeisz C, Tompkins VS, Rosean TR, Klapper W, Tosato G, et al. HHV-8-encoded viral IL-6 collaborates with mouse IL-6 in the development of multicentric Castleman disease in mice. Blood. 2012; 119: 5173-5181.
    • (2012) Blood , vol.119 , pp. 5173-5181
    • Suthaus, J.1    Stuhlmann-Laeisz, C.2    Tompkins, V.S.3    Rosean, T.R.4    Klapper, W.5    Tosato, G.6
  • 94
    • 0029166033 scopus 로고
    • Kaposi's sarcoma-associated herpesvirus-like DNA sequences in multicentric Castleman's disease
    • Soulier J, Grollet L, Oksenhendler E, Cacoub P, Cazals Hatem D, Babinet P, et al. Kaposi's sarcoma-associated herpesvirus-like DNA sequences in multicentric Castleman's disease. Blood. 1995; 86: 1276-1280.
    • (1995) Blood , vol.86 , pp. 1276-1280
    • Soulier, J.1    Grollet, L.2    Oksenhendler, E.3    Cacoub, P.4    Cazals Hatem, D.5    Babinet, P.6
  • 95
    • 27144488346 scopus 로고    scopus 로고
    • Humanized anti-interleukin-6 receptor antibody treatment of multicentric Castleman disease
    • Nishimoto N, Kanakura Y, Aozasa K, Johkoh T, Nakamura M, Nakano S, et al. Humanized anti-interleukin-6 receptor antibody treatment of multicentric Castleman disease. Blood. 2005; 106: 2627-3262.
    • (2005) Blood , vol.106 , pp. 2627-3262
    • Nishimoto, N.1    Kanakura, Y.2    Aozasa, K.3    Johkoh, T.4    Nakamura, M.5    Nakano, S.6
  • 96
    • 58649101347 scopus 로고    scopus 로고
    • Gp130-mediated Stat3 activation in enterocytes regulates cell survival and cell-cycle progression during colitis-associated tumorigenesis
    • Bollrath J, Phesse TJ, von Burstin VA, Putoczki T, Bennecke M, Bateman T, et al. gp130-mediated Stat3 activation in enterocytes regulates cell survival and cell-cycle progression during colitis-associated tumorigenesis. Cancer Cell. 2009; 15: 91-102.
    • (2009) Cancer Cell , vol.15 , pp. 91-102
    • Bollrath, J.1    Phesse, T.J.2    von Burstin, V.A.3    Putoczki, T.4    Bennecke, M.5    Bateman, T.6
  • 98
    • 18344410191 scopus 로고    scopus 로고
    • Blockade of IL-6 transsignaling abrogates established experimental colitis in mice by suppression of the antiapoptotic resistance of lamina propria T cells
    • Atreya R, Mudter J, Finotto S, Müllberg J, Jostock T, Wirtz S, et al. Blockade of IL-6 transsignaling abrogates established experimental colitis in mice by suppression of the antiapoptotic resistance of lamina propria T cells. Nat Med. 2000; 6: 583-588.
    • (2000) Nat Med , vol.6 , pp. 583-588
    • Atreya, R.1    Mudter, J.2    Finotto, S.3    Müllberg, J.4    Jostock, T.5    Wirtz, S.6
  • 99
    • 33747774200 scopus 로고    scopus 로고
    • STAT3 activation via interleukin 6 trans-signalling contributes to ileitis in SAMP1/Yit mice
    • Mitsuyama K, Matsumoto S, Rose-John S, Suzuki A, Hara T, Tomiyasu N, et al. STAT3 activation via interleukin 6 trans-signalling contributes to ileitis in SAMP1/Yit mice. Gut. 2006; 55: 1263-1269.
    • (2006) Gut , vol.55 , pp. 1263-1269
    • Mitsuyama, K.1    Matsumoto, S.2    Rose-John, S.3    Suzuki, A.4    Hara, T.5    Tomiyasu, N.6
  • 100
    • 38949164424 scopus 로고    scopus 로고
    • Transgenic blockade of interleukin 6 transsignaling abrogates inflammation
    • Rabe B, Chalaris A, May U, Waetzig GH, Seegert D, Williams AS, et al. Transgenic blockade of interleukin 6 transsignaling abrogates inflammation. Blood. 2008; 111: 1021-1028.
    • (2008) Blood , vol.111 , pp. 1021-1028
    • Rabe, B.1    Chalaris, A.2    May, U.3    Waetzig, G.H.4    Seegert, D.5    Williams, A.S.6
  • 102
    • 34447572925 scopus 로고    scopus 로고
    • Local blockade of IL-6R signaling induces lung CD4+ T cell apoptosis in a murine model of asthma via regulatory T cells
    • Finotto S, Eigenbrod T, Karwot R, Boross I, Doganci A, Ito H, et al. Local blockade of IL-6R signaling induces lung CD4+ T cell apoptosis in a murine model of asthma via regulatory T cells. Int Immunol. 2007; 19: 685-693.
    • (2007) Int Immunol , vol.19 , pp. 685-693
    • Finotto, S.1    Eigenbrod, T.2    Karwot, R.3    Boross, I.4    Doganci, A.5    Ito, H.6
  • 103
    • 77949326158 scopus 로고    scopus 로고
    • Essential roles of IL-6 trans-signaling in colonic epithelial cells, induced by the IL-6/soluble-IL-6 receptor derived from lamina propria macrophages, on the development of colitis-associated premalignant cancer in a murine model
    • Matsumoto S, Hara T, Mitsuyama K, Yamamoto M, Tsuruta O, Sata M, et al. Essential roles of IL-6 trans-signaling in colonic epithelial cells, induced by the IL-6/soluble-IL-6 receptor derived from lamina propria macrophages, on the development of colitis-associated premalignant cancer in a murine model. J Immunol. 2010; 184: 1543-1551.
    • (2010) J Immunol , vol.184 , pp. 1543-1551
    • Matsumoto, S.1    Hara, T.2    Mitsuyama, K.3    Yamamoto, M.4    Tsuruta, O.5    Sata, M.6
  • 104
    • 78751549236 scopus 로고    scopus 로고
    • IL-6 trans-signaling in formation and progression of malignant ascites in ovarian cancer
    • Lo CW, Chen MW, Hsiao M, Wang S, Chen CA, Hsiao SM, et al. IL-6 trans-signaling in formation and progression of malignant ascites in ovarian cancer. Cancer Res. 2011; 71: 424-434.
    • (2011) Cancer Res , vol.71 , pp. 424-434
    • Lo, C.W.1    Chen, M.W.2    Hsiao, M.3    Wang, S.4    Chen, C.A.5    Hsiao, S.M.6
  • 105
    • 79953756112 scopus 로고    scopus 로고
    • Stat3/Socs3 activation by IL-6 transsignaling promotes progression of pancreatic intraepithelial neoplasia and development of pancreatic cancer
    • Lesina M, Kurkowski MU, Ludes K, Rose-John S, Treiber M, Klöppel G, et al. Stat3/Socs3 activation by IL-6 transsignaling promotes progression of pancreatic intraepithelial neoplasia and development of pancreatic cancer. Cancer Cell. 2011; 19: 456-469.
    • (2011) Cancer Cell , vol.19 , pp. 456-469
    • Lesina, M.1    Kurkowski, M.U.2    Ludes, K.3    Rose-John, S.4    Treiber, M.5    Klöppel, G.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.