메뉴 건너뛰기




Volumn 114, Issue 7, 2009, Pages 1289-1298

The granulocyte-macrophage colony-stimulating factor receptor: Linking its structure to cell signaling and its role in disease

Author keywords

[No Author keywords available]

Indexed keywords

GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR RECEPTOR; INTERLEUKIN 3 RECEPTOR; INTERLEUKIN 5 RECEPTOR; PROTEIN BCL 2; PROTEIN TYROSINE KINASE INHIBITOR;

EID: 70349336496     PISSN: 00064971     EISSN: 15280020     Source Type: Journal    
DOI: 10.1182/blood-2008-12-164004     Document Type: Review
Times cited : (254)

References (144)
  • 1
    • 38349157811 scopus 로고    scopus 로고
    • Hematopoietic cytokines
    • Metcalf D. Hematopoietic cytokines. Blood. 2008;111:485-491.
    • (2008) Blood , vol.111 , pp. 485-491
    • Metcalf, D.1
  • 2
    • 0035838984 scopus 로고    scopus 로고
    • Dendritic cells: Specialized and regulated antigen processing machines
    • Mellman I, Steinman RM. Dendritic cells: specialized and regulated antigen processing machines. Cell. 2001;106:255-258.
    • (2001) Cell , vol.106 , pp. 255-258
    • Mellman, I.1    Steinman, R.M.2
  • 3
    • 0032529495 scopus 로고    scopus 로고
    • Defective expression of granulocyte-macrophage colony-stimulating factor/interleukin-3/interleukin-5 receptor common β chain in children with acute myeloid leukemia associated with respiratory failure
    • Dirksen U, Hattenhorst U, Schneider P, et al. Defective expression of granulocyte-macrophage colony-stimulating factor/interleukin-3/interleukin-5 receptor common β chain in children with acute myeloid leukemia associated with respiratory failure. Blood. 1998;92:1097-1103.
    • (1998) Blood , vol.92 , pp. 1097-1103
    • Dirksen, U.1    Hattenhorst, U.2    Schneider, P.3
  • 4
    • 0028263504 scopus 로고
    • Involvement of granulocyte-macrophage colonystimulating factor in pulmonary homeostasis
    • Dranoff G, Crawford AD, Sadelain M, et al. Involvement of granulocyte-macrophage colonystimulating factor in pulmonary homeostasis. Science. 1994;264:713-716.
    • (1994) Science , vol.264 , pp. 713-716
    • Dranoff, G.1    Crawford, A.D.2    Sadelain, M.3
  • 5
    • 9144247674 scopus 로고    scopus 로고
    • High-affinity autoantibodies specifically eliminate granulocyte- macrophage colony-stimulating factor activity in the lungs of patients with idiopathic pulmonary alveolar proteinosis
    • Uchida K, Nakata K, Trapnell BC, et al. High-affinity autoantibodies specifically eliminate granulocyte-macrophage colony-stimulating factor activity in the lungs of patients with idiopathic pulmonary alveolar proteinosis. Blood. 2004;103:1089-1098.
    • (2004) Blood , vol.103 , pp. 1089-1098
    • Uchida, K.1    Nakata, K.2    Trapnell, B.C.3
  • 6
    • 58149316253 scopus 로고    scopus 로고
    • Pulmonary alveolar proteinosis caused by deletion of the GM-CSFRα gene in the X chromosome pseudoautosomal region 1
    • Martinez-Moczygemba M, Doan ML, Elidemir O, et al. Pulmonary alveolar proteinosis caused by deletion of the GM-CSFRα gene in the X chromosome pseudoautosomal region 1. J Exp Med. 2008;205:2711-2716.
    • (2008) J Exp Med , vol.205 , pp. 2711-2716
    • Martinez-Moczygemba, M.1    Doan, M.L.2    Elidemir, O.3
  • 7
    • 58149313016 scopus 로고    scopus 로고
    • Familial pulmonary alveolar proteinosis caused by mutations in CSF2RA
    • Suzuki T, Sakagami T, Rubin BK, et al. Familial pulmonary alveolar proteinosis caused by mutations in CSF2RA. J Exp Med. 2008;205:2703-2710.
    • (2008) J Exp Med , vol.205 , pp. 2703-2710
    • Suzuki, T.1    Sakagami, T.2    Rubin, B.K.3
  • 8
    • 0028236526 scopus 로고
    • Granulocyte-macrophage colony-stimulating factor-deficient mice show no major perturbation of hematopoiesis but develop a characteristic pulmonary pathology
    • Stanley E, Lieschke GJ, Grail D, et al. Granulocyte-macrophage colony-stimulating factor-deficient mice show no major perturbation of hematopoiesis but develop a characteristic pulmonary pathology. Proc Natl Acad Sci U S A. 1994;91:5592-5596.
    • (1994) Proc Natl Acad Sci U S A , vol.91 , pp. 5592-5596
    • Stanley, E.1    Lieschke, G.J.2    Grail, D.3
  • 9
    • 0028824907 scopus 로고
    • Hematopoietic and lung abnormalities in mice with a null mutation of the common β subunit of the receptors for granulocyte-macrophage colony-stimulating factor and interleukins 3 and 5
    • Robb L, Drinkwater CC, Metcalf D, et al. Hematopoietic and lung abnormalities in mice with a null mutation of the common β subunit of the receptors for granulocyte-macrophage colony-stimulating factor and interleukins 3 and 5. Proc Natl Acad Sci U S A. 1995;92:9565-9569.
    • (1995) Proc Natl Acad Sci U S A , vol.92 , pp. 9565-9569
    • Robb, L.1    Drinkwater, C.C.2    Metcalf, D.3
  • 10
    • 0025881348 scopus 로고
    • Granulocyte-macrophage colony-stimulating factor promotes the proliferation of human alveolar macrophages in vitro
    • Nakata K, Akagawa KS, Fukayama M, et al. Granulocyte-macrophage colony-stimulating factor promotes the proliferation of human alveolar macrophages in vitro. J Immunol. 1991;147:1266-1272.
    • (1991) J Immunol , vol.147 , pp. 1266-1272
    • Nakata, K.1    Akagawa, K.S.2    Fukayama, M.3
  • 11
    • 33947716601 scopus 로고    scopus 로고
    • IL-3 can not replace GM-CSF in inducing human monocytes to differentiate into Langerhans cells
    • Shibasaki T, Katayama N, Ohishi K, et al. IL-3 can not replace GM-CSF in inducing human monocytes to differentiate into Langerhans cells. Int J Oncol. 2007;30:549-555.
    • (2007) Int J Oncol , vol.30 , pp. 549-555
    • Shibasaki, T.1    Katayama, N.2    Ohishi, K.3
  • 12
    • 30344449182 scopus 로고    scopus 로고
    • Functions of granulocyte-macrophage colony-stimulating factor
    • Fleetwood AJ, Cook AD, Hamilton JA. Functions of granulocyte-macrophage colony-stimulating factor. Crit Rev Immunol. 2005;25:405-428.
    • (2005) Crit Rev Immunol , vol.25 , pp. 405-428
    • Fleetwood, A.J.1    Cook, A.D.2    Hamilton, J.A.3
  • 14
    • 47649104857 scopus 로고    scopus 로고
    • Juvenile myelomonocytic leukemia and chronic myelomonocytic leukemia
    • Emanuel PD. Juvenile myelomonocytic leukemia and chronic myelomonocytic leukemia. Leukemia. 2008;22:1335-1342.
    • (2008) Leukemia , vol.22 , pp. 1335-1342
    • Emanuel, P.D.1
  • 15
    • 0026063878 scopus 로고
    • Selective hypersensitivity to granulocyte-macrophage colony-stimulating factor by juvenile chronic myeloid leukemia hematopoietic progenitors
    • Emanuel PD, Bates LJ, Castleberry RP, Gualtieri RJ, Zucherman KS. Selective hypersensitivity to granulocyte-macrophage colony-stimulating factor by juvenile chronic myeloid leukemia hematopoietic progenitors. Blood. 1991;77:925-929.
    • (1991) Blood , vol.77 , pp. 925-929
    • Emanuel, P.D.1    Bates, L.J.2    Castleberry, R.P.3    Gualtieri, R.J.4    Zucherman, K.S.5
  • 16
    • 0030925139 scopus 로고    scopus 로고
    • Deoxyribonucleic acid triplex formation inhibits granulocyte macrophage colony-stimulating factor gene expression and suppresses growth in juvenile myelomonocytic leukemic cells
    • Kochetkova M, Iversen PO, Lopez AF, Shannon MF. Deoxyribonucleic acid triplex formation inhibits granulocyte macrophage colony-stimulating factor gene expression and suppresses growth in juvenile myelomonocytic leukemic cells. J Clin Invest. 1997;99:3000-3008.
    • (1997) J Clin Invest , vol.99 , pp. 3000-3008
    • Kochetkova, M.1    Iversen, P.O.2    Lopez, A.F.3    Shannon, M.F.4
  • 17
    • 0033982718 scopus 로고    scopus 로고
    • Nf1 and Gmcsf interact in myeloid leukemogenesis
    • Birnbaum RA, O'Marcaigh A, Wardak Z, et al. Nf1 and Gmcsf interact in myeloid leukemogenesis. Mol Cell. 2000;5:189-195.
    • (2000) Mol Cell , vol.5 , pp. 189-195
    • Birnbaum, R.A.1    O'Marcaigh, A.2    Wardak, Z.3
  • 18
    • 33846902274 scopus 로고    scopus 로고
    • Beta common receptor inactivation attenuates myeloproliferative disease in Nf1 mutant mice
    • Kim A, Morgan K, Hasz DE, et al. Beta common receptor inactivation attenuates myeloproliferative disease in Nf1 mutant mice. Blood. 2007;109:1687-1691.
    • (2007) Blood , vol.109 , pp. 1687-1691
    • Kim, A.1    Morgan, K.2    Hasz, D.E.3
  • 19
    • 0036789943 scopus 로고    scopus 로고
    • Chronic myelomonocytic leukemia requires granulocyte-macrophage colony-stimulating factor for growth in vitro and in vivo
    • Ramshaw HS, Bardy PG, Lee M, Lopez AF. Chronic myelomonocytic leukemia requires granulocyte-macrophage colony-stimulating factor for growth in vitro and in vivo. Exp Hematol. 2002;30:1124-1131.
    • (2002) Exp Hematol , vol.30 , pp. 1124-1131
    • Ramshaw, H.S.1    Bardy, P.G.2    Lee, M.3    Lopez, A.F.4
  • 20
    • 33744457651 scopus 로고    scopus 로고
    • Molecular basis of the diagnosis and treatment of polycythemia vera and essential thrombocythemia
    • Schafer AI. Molecular basis of the diagnosis and treatment of polycythemia vera and essential thrombocythemia. Blood. 2006;107:4214-4222.
    • (2006) Blood , vol.107 , pp. 4214-4222
    • Schafer, A.I.1
  • 21
    • 0011134388 scopus 로고
    • RAS gene mutations in acute and chronic myelocytic leukemias, chronic myeloproliferative disorders, and myelodysplastic syndromes
    • Janssen JW, Steenvoorden AC, Lyons J, et al. RAS gene mutations in acute and chronic myelocytic leukemias, chronic myeloproliferative disorders, and myelodysplastic syndromes. Proc Natl Acad Sci U S A. 1987;84:9228-9232.
    • (1987) Proc Natl Acad Sci U S A , vol.84 , pp. 9228-9232
    • Janssen, J.W.1    Steenvoorden, A.C.2    Lyons, J.3
  • 22
    • 32544439898 scopus 로고    scopus 로고
    • Growth factor pleiotropy is controlled by a receptor Tyr/Ser motif that acts as a binary switch
    • Guthridge MA, Powell JA, Barry EF, et al. Growth factor pleiotropy is controlled by a receptor Tyr/Ser motif that acts as a binary switch. EMBO J. 2006;25:479-489.
    • (2006) EMBO J , vol.25 , pp. 479-489
    • Guthridge, M.A.1    Powell, J.A.2    Barry, E.F.3
  • 23
    • 0029680564 scopus 로고    scopus 로고
    • P210 Bcr-Abl interacts with the interleukin 3 receptor β (c) subunit and constitutively induces its tyrosine phosphorylation
    • Wilson-Rawls J, Xie S, Liu J, Laneuville P, Arlinghaus RB. P210 Bcr-Abl interacts with the interleukin 3 receptor β (c) subunit and constitutively induces its tyrosine phosphorylation. Cancer Res. 1996;56:3426-3430.
    • (1996) Cancer Res , vol.56 , pp. 3426-3430
    • Wilson-Rawls, J.1    Xie, S.2    Liu, J.3    Laneuville, P.4    Arlinghaus, R.B.5
  • 24
    • 17844383458 scopus 로고    scopus 로고
    • A unique clonal JAK2 mutation leading to constitutive signalling causes polycythaemia vera
    • James C, Ugo V, Le Couedic JP, et al. A unique clonal JAK2 mutation leading to constitutive signalling causes polycythaemia vera. Nature. 2005;434:1144-1148.
    • (2005) Nature , vol.434 , pp. 1144-1148
    • James, C.1    Ugo, V.2    Le Couedic, J.P.3
  • 25
    • 46249090513 scopus 로고    scopus 로고
    • Colony-stimulating factors in inflammation and autoimmunity
    • Hamilton JA. Colony-stimulating factors in inflammation and autoimmunity. Nat Rev Immunol. 2008;8:533-544.
    • (2008) Nat Rev Immunol , vol.8 , pp. 533-544
    • Hamilton, J.A.1
  • 26
    • 34250817984 scopus 로고    scopus 로고
    • Administration of cyclooxygenase-2 inhibitor reduces joint inflammation but exacerbates osteopenia in IL-1α transgenic mice due to GM-CSF overproduction
    • Niki Y, Takaishi H, Takito J, et al. Administration of cyclooxygenase-2 inhibitor reduces joint inflammation but exacerbates osteopenia in IL-1α transgenic mice due to GM-CSF overproduction. J Immunol. 2007;179:639-646.
    • (2007) J Immunol , vol.179 , pp. 639-646
    • Niki, Y.1    Takaishi, H.2    Takito, J.3
  • 27
    • 0030744451 scopus 로고    scopus 로고
    • Granulocyte-macrophage colony stimulating factor exacerbates collagen induced arthritis in mice
    • Campbell IK, Bendele A, Smith DA, Hamilton JA. Granulocyte-macrophage colony stimulating factor exacerbates collagen induced arthritis in mice. Ann Rheum Dis. 1997;56:364-368.
    • (1997) Ann Rheum Dis , vol.56 , pp. 364-368
    • Campbell, I.K.1    Bendele, A.2    Smith, D.A.3    Hamilton, J.A.4
  • 28
    • 0032193230 scopus 로고    scopus 로고
    • Protection from collagen-induced arthritis in granulocyte-macrophage colony-stimulating factor-deficient mice
    • Campbell IK, Rich MJ, Bischof RJ, et al. Protection from collagen-induced arthritis in granulocyte-macrophage colony-stimulating factor-deficient mice. J Immunol. 1998;161:3639-3644.
    • (1998) J Immunol , vol.161 , pp. 3639-3644
    • Campbell, I.K.1    Rich, M.J.2    Bischof, R.J.3
  • 29
    • 0022049874 scopus 로고
    • Specific binding of radio-iodinated granulocyte-macrophage colony-stimulating factor to hemopoietic cells
    • Walker F, Burgess AW. Specific binding of radio-iodinated granulocyte-macrophage colony-stimulating factor to hemopoietic cells. EMBO J 1985;4:933-939.
    • (1985) EMBO J , vol.4 , pp. 933-939
    • Walker, F.1    Burgess, A.W.2
  • 30
    • 0022443639 scopus 로고
    • Characterization of the cell surface receptor for human granulocyte/macrophage colony-stimulating factor
    • Park LS, Friend D, Gillis S, Urdal DL. Characterization of the cell surface receptor for human granulocyte/macrophage colony-stimulating factor. J Exp Med. 1986;164:251-262.
    • (1986) J Exp Med , vol.164 , pp. 251-262
    • Park, L.S.1    Friend, D.2    Gillis, S.3    Urdal, D.L.4
  • 31
    • 0024846310 scopus 로고
    • Expression cloning of a receptor for human granulocyte-macrophage colony-stimulating factor
    • Gearing DP, King JA, Gough NM, Nicola NA. Expression cloning of a receptor for human granulocyte-macrophage colony-stimulating factor. EMBO J. 1989;8:3667-3676.
    • (1989) EMBO J , vol.8 , pp. 3667-3676
    • Gearing, D.P.1    King, J.A.2    Gough, N.M.3    Nicola, N.A.4
  • 32
    • 0025637605 scopus 로고
    • Molecular cloning of a second subunit of the receptor for human granulocyte-macrophage colony-stimulating factor (GM-CSF): Reconstitution of a high-affinity GM-CSF receptor
    • Hayashida K, Kitamura T, Gorman DM, et al. Molecular cloning of a second subunit of the receptor for human granulocyte-macrophage colony-stimulating factor (GM-CSF): reconstitution of a high-affinity GM-CSF receptor. Proc Natl Acad Sci U S A. 1990;87:9655-9659.
    • (1990) Proc Natl Acad Sci U S A , vol.87 , pp. 9655-9659
    • Hayashida, K.1    Kitamura, T.2    Gorman, D.M.3
  • 33
    • 0024549443 scopus 로고
    • Nonhematopoietic tumor cells express functional GMC-SF receptors
    • Baldwin G, Gasson J, Kaufman S, et al. Nonhematopoietic tumor cells express functional GMC-SF receptors. Blood. 1989;73:1033-1037.
    • (1989) Blood , vol.73 , pp. 1033-1037
    • Baldwin, G.1    Gasson, J.2    Kaufman, S.3
  • 34
    • 0001367781 scopus 로고
    • Human granulocyte-macrophage colony-stimulating factor is a growth factor active on a variety of cell types of nonhemopoietic origin
    • Dedhar S, Gaboury L, Galloway P, Eaves C. Human granulocyte-macrophage colony-stimulating factor is a growth factor active on a variety of cell types of nonhemopoietic origin. Proc Natl Acad Sci U S A. 1988;85:9253-9257.
    • (1988) Proc Natl Acad Sci U S A , vol.85 , pp. 9253-9257
    • Dedhar, S.1    Gaboury, L.2    Galloway, P.3    Eaves, C.4
  • 35
    • 0024531796 scopus 로고
    • Granulocyte- and granulocyte-macrophage-colony stimulating factors induce human endothelial cells to migrate and proliferate
    • Bussolino F, Wang JM, Defilippi P, et al. Granulocyte- and granulocyte-macrophage-colony stimulating factors induce human endothelial cells to migrate and proliferate. Nature. 1989;337:471-473.
    • (1989) Nature , vol.337 , pp. 471-473
    • Bussolino, F.1    Wang, J.M.2    Defilippi, P.3
  • 36
    • 0032006883 scopus 로고    scopus 로고
    • Expression of granulocyte-macrophage colony-stimulating factor receptors in human prostate cancer
    • Rivas CI, Vera JC, Delgado-Lopez F, et al. Expression of granulocyte-macrophage colony-stimulating factor receptors in human prostate cancer. Blood. 1998;91:1037-1043.
    • (1998) Blood , vol.91 , pp. 1037-1043
    • Rivas, C.I.1    Vera, J.C.2    Delgado-Lopez, F.3
  • 37
    • 0033970452 scopus 로고    scopus 로고
    • Novel murine myeloid cell lines that exhibit a differentiation switch in response to IL-3 or GM-CSF, or to different constitutively active mutants of the GM-CSF receptor β subunit
    • McCormack MP, Gonda TJ. Novel murine myeloid cell lines that exhibit a differentiation switch in response to IL-3 or GM-CSF, or to different constitutively active mutants of the GM-CSF receptor β subunit. Blood. 2000;95:120-127.
    • (2000) Blood , vol.95 , pp. 120-127
    • McCormack, M.P.1    Gonda, T.J.2
  • 38
    • 58149151542 scopus 로고    scopus 로고
    • IL-3 induces a Pim1-dependent antiapoptotic pathway in primary human basophils
    • Didichenko SA, Spiegl N, Brunner T, Dahinden CA. IL-3 induces a Pim1-dependent antiapoptotic pathway in primary human basophils. Blood. 2008;112:3949-3958.
    • (2008) Blood , vol.112 , pp. 3949-3958
    • Didichenko, S.A.1    Spiegl, N.2    Brunner, T.3    Dahinden, C.A.4
  • 39
    • 48449102092 scopus 로고    scopus 로고
    • The structure of the GM-CSF receptor complex reveals a distinct mode of cytokine receptor assembly
    • Hansen G, Hercus TR, McClure BJ, et al. The structure of the GM-CSF receptor complex reveals a distinct mode of cytokine receptor assembly. Cell. 2008;134:496-507.
    • (2008) Cell , vol.134 , pp. 496-507
    • Hansen, G.1    Hercus, T.R.2    McClure, B.J.3
  • 40
    • 0026065403 scopus 로고
    • Identification of functionally distinct domains of human granulocyte-macrophage colony-stimulating factor using monoclonal antibodies
    • Kanakura Y, Cannistra SA, Brown CB, et al. Identification of functionally distinct domains of human granulocyte-macrophage colony-stimulating factor using monoclonal antibodies. Blood. 1991;77:1033-1043.
    • (1991) Blood , vol.77 , pp. 1033-1043
    • Kanakura, Y.1    Cannistra, S.A.2    Brown, C.B.3
  • 41
    • 0025610054 scopus 로고
    • Monoclonal antibodies that recognize human granulocyte-macrophage colony-stimulating factor and neutralize its bioactivity in vitro
    • Dempsey PJ, Layton JE, Duhrsen U, et al. Monoclonal antibodies that recognize human granulocyte-macrophage colony-stimulating factor and neutralize its bioactivity in vitro. Hybridoma. 1990;9:545-558.
    • (1990) Hybridoma , vol.9 , pp. 545-558
    • Dempsey, P.J.1    Layton, J.E.2    Duhrsen, U.3
  • 42
    • 0033568467 scopus 로고    scopus 로고
    • Simultaneous antagonism of interleukin-5, granulocyte-macrophage colony-stimulating factor, and interleukin-3 stimulation of human eosinophils by targetting the common cytokine binding site of their receptors
    • Sun Q, Jones K, McClure B, et al. Simultaneous antagonism of interleukin-5, granulocyte-macrophage colony-stimulating factor, and interleukin-3 stimulation of human eosinophils by targetting the common cytokine binding site of their receptors. Blood. 1999;94:1943-1951.
    • (1999) Blood , vol.94 , pp. 1943-1951
    • Sun, Q.1    Jones, K.2    McClure, B.3
  • 43
    • 0028233122 scopus 로고
    • Identification of residues in the first and fourth helices of human granulocyte-macrophage colony stimulating factor involved in binding to the α- and β-chains of the receptor
    • Hercus TR, Cambareri B, Dottore M, et al. Identification of residues in the first and fourth helices of human granulocyte-macrophage colony stimulating factor involved in binding to the α- and β-chains of the receptor. Blood. 1994;83:3500-3508.
    • (1994) Blood , vol.83 , pp. 3500-3508
    • Hercus, T.R.1    Cambareri, B.2    Dottore, M.3
  • 45
    • 0029860206 scopus 로고    scopus 로고
    • A single tyrosine residue in the membrane-proximal domain of the GM-CSF, IL-3 and IL-5 receptor common β chain is necessary and sufficient for high affinity binding and signalling by all three ligands
    • Woodcock JM, Bagley CJ, Zacharakis B, Lopez AF. A single tyrosine residue in the membrane-proximal domain of the GM-CSF, IL-3 and IL-5 receptor common β chain is necessary and sufficient for high affinity binding and signalling by all three ligands. J Biol Chem. 1996;271:25999-26006.
    • (1996) J Biol Chem , vol.271 , pp. 25999-26006
    • Woodcock, J.M.1    Bagley, C.J.2    Zacharakis, B.3    Lopez, A.F.4
  • 46
    • 0030960120 scopus 로고    scopus 로고
    • Crucial role of the residue R280 at the F′-G′ loop of the human granulocyte/macrophage colony-stimulating factor receptor α chain for ligand recognition
    • Rajotte D, Cadieux C, Haman A, et al. Crucial role of the residue R280 at the F′-G′ loop of the human granulocyte/macrophage colony-stimulating factor receptor α chain for ligand recognition. J Exp Med. 1997;185:1939-1950.
    • (1997) J Exp Med , vol.185 , pp. 1939-1950
    • Rajotte, D.1    Cadieux, C.2    Haman, A.3
  • 47
    • 0033607540 scopus 로고    scopus 로고
    • Molecular determinants of the granulocyte-macrophage colony-stimulating factor receptor complex assembly
    • Haman A, Cadieux C, Wilkes B, et al. Molecular determinants of the granulocyte-macrophage colony-stimulating factor receptor complex assembly. J Biol Chem. 1999;274:34155-34163.
    • (1999) J Biol Chem , vol.274 , pp. 34155-34163
    • Haman, A.1    Cadieux, C.2    Wilkes, B.3
  • 48
    • 0025766757 scopus 로고
    • Identification of critical amino acid residues in human and mouse granulocyte-macrophage colony-stimulating factor and their involvement in species specificity
    • Shanafelt AB, Johnson KE, Kastelein RA. Identification of critical amino acid residues in human and mouse granulocyte-macrophage colony-stimulating factor and their involvement in species specificity. J Biol Chem. 1991;266:13804-13810.
    • (1991) J Biol Chem , vol.266 , pp. 13804-13810
    • Shanafelt, A.B.1    Johnson, K.E.2    Kastelein, R.A.3
  • 49
    • 0028013295 scopus 로고
    • Histidine-367 of the human common β chain of the receptor is critical for high-affinity binding of human granulocyte-macrophage colony-stimulating factor
    • Lock P, Metcalf D, Nicola NA. Histidine-367 of the human common β chain of the receptor is critical for high-affinity binding of human granulocyte-macrophage colony-stimulating factor. Proc Natl Acad Sci U S A. 1994;91:252-256.
    • (1994) Proc Natl Acad Sci U S A , vol.91 , pp. 252-256
    • Lock, P.1    Metcalf, D.2    Nicola, N.A.3
  • 50
    • 0029805606 scopus 로고    scopus 로고
    • Refined crystal structure and mutagenesis of human granulocyte-macrophage colony-stimulating factor
    • Rozwarski DA, Diederichs K, Hecht R, Boone T, Karplus PA. Refined crystal structure and mutagenesis of human granulocyte-macrophage colony-stimulating factor. Proteins. 1996;26:304-313.
    • (1996) Proteins , vol.26 , pp. 304-313
    • Rozwarski, D.A.1    Diederichs, K.2    Hecht, R.3    Boone, T.4    Karplus, P.A.5
  • 51
    • 0034655647 scopus 로고    scopus 로고
    • Structure of the activation domain of the GMC-SF/IL-3/IL-5 receptor common β chain bound to an antagonist
    • Rossjohn J, McKinstry WJ, Woodcock JM, et al. Structure of the activation domain of the GMC-SF/IL-3/IL-5 receptor common β chain bound to an antagonist. Blood. 2000;95:2491-2498.
    • (2000) Blood , vol.95 , pp. 2491-2498
    • Rossjohn, J.1    McKinstry, W.J.2    Woodcock, J.M.3
  • 52
    • 0034615779 scopus 로고    scopus 로고
    • The solution structure of the cytokine-binding domain of the common β-chain of the receptors for granulocyte-macrophage colony-stimulating factor, interleukin-3 and interleukin-5
    • Mulhern TD, Lopez AF, D'Andrea RJ, et al. The solution structure of the cytokine-binding domain of the common β-chain of the receptors for granulocyte-macrophage colony-stimulating factor, interleukin-3 and interleukin-5. J Mol Biol. 2000;297:989-1001.
    • (2000) J Mol Biol , vol.297 , pp. 989-1001
    • Mulhern, T.D.1    Lopez, A.F.2    D'Andrea, R.J.3
  • 53
    • 17744386517 scopus 로고    scopus 로고
    • Structure of the complete extracellular domain of the common β subunit of the human GM-CSF, IL-3, and IL-5 receptors reveals a novel dimer configuration
    • Carr PD, Gustin SE, Church AP, et al. Structure of the complete extracellular domain of the common β subunit of the human GM-CSF, IL-3, and IL-5 receptors reveals a novel dimer configuration. Cell. 2001;104:291-300.
    • (2001) Cell , vol.104 , pp. 291-300
    • Carr, P.D.1    Gustin, S.E.2    Church, A.P.3
  • 54
    • 0344089342 scopus 로고    scopus 로고
    • Molecular assembly of the ternary granulocyte-macrophage colony-stimulating factor receptor complex
    • McClure BJ, Hercus TR, Cambareri BA, et al. Molecular assembly of the ternary granulocyte-macrophage colony-stimulating factor receptor complex. Blood. 2003;101:1308-1315.
    • (2003) Blood , vol.101 , pp. 1308-1315
    • McClure, B.J.1    Hercus, T.R.2    Cambareri, B.A.3
  • 55
    • 49249101222 scopus 로고    scopus 로고
    • Crystallization and preliminary X-ray diffraction analysis of the ternary human GM-CSF receptor complex
    • Hansen G, Hercus TR, Xu Y, et al. Crystallization and preliminary X-ray diffraction analysis of the ternary human GM-CSF receptor complex. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2008;64:711-714.
    • (2008) Acta Crystallogr Sect F Struct Biol Cryst Commun , vol.64 , pp. 711-714
    • Hansen, G.1    Hercus, T.R.2    Xu, Y.3
  • 56
    • 33745152640 scopus 로고    scopus 로고
    • An improved resolution structure of the human β common receptor involved in IL-3, IL-5 and GM-CSF signalling which gives better definition of the high-affinity binding epitope
    • Carr PD, Conlan F, Ford S, Ollis DL, Young IG. An improved resolution structure of the human β common receptor involved in IL-3, IL-5 and GM-CSF signalling which gives better definition of the high-affinity binding epitope. Acta Crystallographr Sect F Struct Biol Cryst Commun. 2006;62:509-513.
    • (2006) Acta Crystallographr Sect F Struct Biol Cryst Commun , vol.62 , pp. 509-513
    • Carr, P.D.1    Conlan, F.2    Ford, S.3    Ollis, D.L.4    Young, I.G.5
  • 57
    • 0026598960 scopus 로고
    • Human growth hormone and extracellular domain of its receptor: Crystal structure of the complex
    • de Vos AM, Ultsch M, Kossiakoff AA. Human growth hormone and extracellular domain of its receptor: crystal structure of the complex. Science. 1992;255:306-312.
    • (1992) Science , vol.255 , pp. 306-312
    • De Vos, A.M.1    Ultsch, M.2    Kossiakoff, A.A.3
  • 58
    • 0029982521 scopus 로고    scopus 로고
    • Hematopoietic receptor complexes
    • Wells JA, De Vos AM. Hematopoietic receptor complexes. Annu Rev Biochem. 1996;65:609-634.
    • (1996) Annu Rev Biochem , vol.65 , pp. 609-634
    • Wells, J.A.1    De Vos, A.M.2
  • 59
    • 0026511904 scopus 로고
    • Residue 21 of human granulocyte-macrophage colony-stimulating factor is critical for biological activity and for high but not low affinity binding
    • Lopez AF, Shannon MF, Hercus T, et al. Residue 21 of human granulocyte-macrophage colony-stimulating factor is critical for biological activity and for high but not low affinity binding. EMBO J. 1992;11:909-916.
    • (1992) EMBO J , vol.11 , pp. 909-916
    • Lopez, A.F.1    Shannon, M.F.2    Hercus, T.3
  • 60
    • 0028226252 scopus 로고
    • Specific human granulocyte-macrophage colony-stimulating factor antagonists
    • Hercus TR, Bagley CJ, Cambareri B, et al. Specific human granulocyte-macrophage colony-stimulating factor antagonists. Proc Natl Acad Sci U S A. 1994;91:5838-5842.
    • (1994) Proc Natl Acad Sci U S A , vol.91 , pp. 5838-5842
    • Hercus, T.R.1    Bagley, C.J.2    Cambareri, B.3
  • 61
    • 0038532303 scopus 로고    scopus 로고
    • A novel functional epitope formed by domains 1 and 4 of the human common β-subunit is involved in receptor activation by granulocyte macrophage colony-stimulating factor and interleukin 5
    • Murphy JM, Ford SC, Wiedemann UM, et al. A novel functional epitope formed by domains 1 and 4 of the human common β-subunit is involved in receptor activation by granulocyte macrophage colony-stimulating factor and interleukin 5. J Biol Chem. 2003;278:10572-10577.
    • (2003) J Biol Chem , vol.278 , pp. 10572-10577
    • Murphy, J.M.1    Ford, S.C.2    Wiedemann, U.M.3
  • 62
    • 0028245262 scopus 로고
    • Two contiguous residues in human interleukin-3, Asp21 and Glu22, selectively interact with the α- and β-chains of its receptor and participate in function
    • Barry SC, Bagley CJ, Phillips J, et al. Two contiguous residues in human interleukin-3, Asp21 and Glu22, selectively interact with the α- and β-chains of its receptor and participate in function. J Biol Chem. 1994;269:8488-8492.
    • (1994) J Biol Chem , vol.269 , pp. 8488-8492
    • Barry, S.C.1    Bagley, C.J.2    Phillips, J.3
  • 63
    • 0029000927 scopus 로고
    • Identification of receptor-binding domains on human interleukin 5 and design of an interleukin 5-derived receptor antagonist
    • Tavernier J, Tuypens T, Verhee A, et al. Identification of receptor-binding domains on human interleukin 5 and design of an interleukin 5-derived receptor antagonist. Proc Natl Acad Sci U S A. 1995;92:5194-5198.
    • (1995) Proc Natl Acad Sci U S A , vol.92 , pp. 5194-5198
    • Tavernier, J.1    Tuypens, T.2    Verhee, A.3
  • 64
    • 0030744972 scopus 로고    scopus 로고
    • The human granulocyte-macrophage colony-stimulating factor (GM-CSF) receptor exists as a preformed receptor complex that can be activated by GM-CSF interleukin-3, or interleukin-5
    • Woodcock JM, McClure B, Stomski FC, et al. The human granulocyte- macrophage colony-stimulating factor (GM-CSF) receptor exists as a preformed receptor complex that can be activated by GM-CSF interleukin-3, or interleukin-5. Blood. 1997;90:3005-3017.
    • (1997) Blood , vol.90 , pp. 3005-3017
    • Woodcock, J.M.1    McClure, B.2    Stomski, F.C.3
  • 66
    • 0141527338 scopus 로고    scopus 로고
    • Convergent mechanisms for recognition of divergent cytokines by the shared signaling receptor gp130
    • Boulanger MJ, Bankovich AJ, Kortemme T, Baker D, Garcia KC. Convergent mechanisms for recognition of divergent cytokines by the shared signaling receptor gp130. Mol Cell. 2003;12:577-589.
    • (2003) Mol Cell , vol.12 , pp. 577-589
    • Boulanger, M.J.1    Bankovich, A.J.2    Kortemme, T.3    Baker, D.4    Garcia, K.C.5
  • 67
    • 27944505913 scopus 로고    scopus 로고
    • Structure of the quaternary complex of interleukin-2 with its α, β, and γc receptors
    • Wang X, Rickert M, Garcia KC. Structure of the quaternary complex of interleukin-2 with its α, β, and γc receptors. Science. 2005;310:1159-1163.
    • (2005) Science , vol.310 , pp. 1159-1163
    • Wang, X.1    Rickert, M.2    Garcia, K.C.3
  • 68
    • 33644540157 scopus 로고    scopus 로고
    • Crystal structure of the IL-2 signaling complex: Paradigm for a heterotrimeric cytokine receptor
    • Stauber DJ, Debler EW, Horton PA, Smith KA, Wilson IA. Crystal structure of the IL-2 signaling complex: paradigm for a heterotrimeric cytokine receptor. Proc Natl Acad Sci U S A. 2006;103:2788-2793.
    • (2006) Proc Natl Acad Sci U S A , vol.103 , pp. 2788-2793
    • Stauber, D.J.1    Debler, E.W.2    Horton, P.A.3    Smith, K.A.4    Wilson, I.A.5
  • 69
    • 38649137731 scopus 로고    scopus 로고
    • Molecular and structural basis of cytokine receptor pleiotropy in the interleukin-4/13 system
    • LaPorte SL, Juo ZS, Vaclavikova J, et al. Molecular and structural basis of cytokine receptor pleiotropy in the interleukin-4/13 system. Cell. 2008;132:259-272.
    • (2008) Cell , vol.132 , pp. 259-272
    • LaPorte, S.L.1    Juo, Z.S.2    Vaclavikova, J.3
  • 70
    • 0033574713 scopus 로고    scopus 로고
    • Crystal structure of the interleukin-4/receptor α chain complex reveals a mosaic binding interface
    • Hage T, Sebald W, Reinemer P. Crystal structure of the interleukin-4/receptor α chain complex reveals a mosaic binding interface. Cell. 1999;97:271-281.
    • (1999) Cell , vol.97 , pp. 271-281
    • Hage, T.1    Sebald, W.2    Reinemer, P.3
  • 71
    • 22444442637 scopus 로고    scopus 로고
    • Signaling conformations of the tall cytokine receptor gp130 when in complex with IL-6 and IL-6 receptor
    • Skiniotis G, Boulanger MJ, Garcia KC, Walz T. Signaling conformations of the tall cytokine receptor gp130 when in complex with IL-6 and IL-6 receptor. Nat Struct Mol Biol. 2005;12:545-551.
    • (2005) Nat Struct Mol Biol , vol.12 , pp. 545-551
    • Skiniotis, G.1    Boulanger, M.J.2    Garcia, K.C.3    Walz, T.4
  • 72
    • 0034644539 scopus 로고    scopus 로고
    • Cell signaling by receptor tyrosine kinases
    • Schlessinger J. Cell signaling by receptor tyrosine kinases. Cell. 2000;103:211-225.
    • (2000) Cell , vol.103 , pp. 211-225
    • Schlessinger, J.1
  • 73
    • 0026733625 scopus 로고
    • Critical cytoplasmic domains of the common β subunit of the human GM-CSF, IL-3 and IL-5 receptors for growth signal transduction and tyrosine phosphorylation
    • Sakamaki K, Miyajima I, Kitamura T, Miyajima A. Critical cytoplasmic domains of the common β subunit of the human GM-CSF, IL-3 and IL-5 receptors for growth signal transduction and tyrosine phosphorylation. EMBO J. 1992;11:3541-3549.
    • (1992) EMBO J , vol.11 , pp. 3541-3549
    • Sakamaki, K.1    Miyajima, I.2    Kitamura, T.3    Miyajima, A.4
  • 74
    • 0029598480 scopus 로고
    • Roles of the cytoplasmic domains of the α and β subunits of human granulocyte-macrophage colony-stimulating factor receptor
    • Muto A, Watanabe S, Itoh T, et al. Roles of the cytoplasmic domains of the α and β subunits of human granulocyte-macrophage colony-stimulating factor receptor. J Allergy Clin Immunol. 1995;96:1100-1114.
    • (1995) J Allergy Clin Immunol , vol.96 , pp. 1100-1114
    • Muto, A.1    Watanabe, S.2    Itoh, T.3
  • 75
    • 0027960979 scopus 로고
    • Convergence of signaling by interleukin-3, granulocyte-macrophage colony-stimulating factor, and mast cell growth factor on JAK2 tyrosine kinase
    • Brizzi MF, Zini MG, Aronica MG, et al. Convergence of signaling by interleukin-3, granulocyte-macrophage colony-stimulating factor, and mast cell growth factor on JAK2 tyrosine kinase. J Biol Chem. 1994;269:31680-31684.
    • (1994) J Biol Chem , vol.269 , pp. 31680-31684
    • Brizzi, M.F.1    Zini, M.G.2    Aronica, M.G.3
  • 76
    • 0028180569 scopus 로고
    • c chain of the receptor for granulocyte-macrophage colony-stimulating factor, and its activation requires the membrane proximal region
    • c chain of the receptor for granulocyte-macrophage colony-stimulating factor, and its activation requires the membrane proximal region. Mol Cell Biol. 1994;14:4335-4341.
    • (1994) Mol Cell Biol , vol.14 , pp. 4335-4341
    • Quelle, F.W.1    Sato, N.2    Witthuhn, B.A.3
  • 77
    • 0035869410 scopus 로고    scopus 로고
    • Distinct domains of the human granulocyte-macrophage colony-stimulating factor receptor α subunit mediate activation of Jak/Stat signaling and differentiation
    • Lilly MB, Zemskova M, Frankel AE, Salo J, Kraft AS. Distinct domains of the human granulocyte-macrophage colony-stimulating factor receptor α subunit mediate activation of Jak/Stat signaling and differentiation. Blood. 2001;97:1662-1670.
    • (2001) Blood , vol.97 , pp. 1662-1670
    • Lilly, M.B.1    Zemskova, M.2    Frankel, A.E.3    Salo, J.4    Kraft, A.S.5
  • 78
    • 0029903629 scopus 로고    scopus 로고
    • A dominant negative granulocyte-macrophage colony-stimuating factor receptor α chain reveals the multimeric structure of the receptor complex
    • Lia F, Rajotte D, Clark SC, Hoang T. A dominant negative granulocyte-macrophage colony-stimuating factor receptor α chain reveals the multimeric structure of the receptor complex. J Biol Chem. 1996;271:28287-28293.
    • (1996) J Biol Chem , vol.271 , pp. 28287-28293
    • Lia, F.1    Rajotte, D.2    Clark, S.C.3    Hoang, T.4
  • 79
    • 65549106958 scopus 로고    scopus 로고
    • A new isoform of interleukin-3 receptor α with novel differentiation activity and high affinity binding mode
    • Chen J, Olsen J, Ford S, et al. A new isoform of interleukin-3 receptor α with novel differentiation activity and high affinity binding mode. J Biol Chem. 2009;284:5763-5773.
    • (2009) J Biol Chem , vol.284 , pp. 5763-5773
    • Chen, J.1    Olsen, J.2    Ford, S.3
  • 80
    • 0031667742 scopus 로고    scopus 로고
    • Mechanism of activation of the GM-CSF, IL-3 and IL-5 family of receptors
    • Guthridge MA, Stomski FC, Thomas D, et al. Mechanism of activation of the GM-CSF, IL-3 and IL-5 family of receptors. Stem Cells. 1998;16:301-313.
    • (1998) Stem Cells , vol.16 , pp. 301-313
    • Guthridge, M.A.1    Stomski, F.C.2    Thomas, D.3
  • 81
    • 0028872649 scopus 로고
    • Specificity of receptor tyrosine kinase signaling: Transient versus sustained extracellular signal-regulated kinase activation
    • Marshall CJ. Specificity of receptor tyrosine kinase signaling: transient versus sustained extracellular signal-regulated kinase activation. Cell. 1995;80:179-185.
    • (1995) Cell , vol.80 , pp. 179-185
    • Marshall, C.J.1
  • 82
    • 0033635183 scopus 로고    scopus 로고
    • Site-specific serine phosphorylation of the IL-3 receptor is required for hemopoietic cell survival
    • Guthridge MA, Stomski FC, Barry EF, et al. Site-specific serine phosphorylation of the IL-3 receptor is required for hemopoietic cell survival. Mol Cell. 2000;6:99-108.
    • (2000) Mol Cell , vol.6 , pp. 99-108
    • Guthridge, M.A.1    Stomski, F.C.2    Barry, E.F.3
  • 83
    • 1642541230 scopus 로고    scopus 로고
    • The phosphoserine-585-dependent pathway of the GM-CSF/IL-3/IL-5 receptors mediates hematopoietic cell survival through activation of NF-κB and induction of bcl-2
    • Guthridge MA, Barry EF, Felquer FA, et al. The phosphoserine-585- dependent pathway of the GM-CSF/IL-3/IL-5 receptors mediates hematopoietic cell survival through activation of NF-κB and induction of bcl-2. Blood. 2004;103:820-827.
    • (2004) Blood , vol.103 , pp. 820-827
    • Guthridge, M.A.1    Barry, E.F.2    Felquer, F.A.3
  • 84
    • 0022539985 scopus 로고
    • Purified colony-stimulating factors enhance the survival of human neutrophils and eosinophils in vitro: A rapid and sensitive microassay for colony-stimulating factors
    • Begley CG, Lopez AF, Nicola NA, et al. Purified colony-stimulating factors enhance the survival of human neutrophils and eosinophils in vitro: a rapid and sensitive microassay for colony-stimulating factors. Blood. 1986;68:162-166.
    • (1986) Blood , vol.68 , pp. 162-166
    • Begley, C.G.1    Lopez, A.F.2    Nicola, N.A.3
  • 85
    • 0025091773 scopus 로고
    • Haemopoietic colony stimulating factors promote cell survival by suppressing apoptosis
    • Williams GT, Smith CA, Spooncer E, Dexter TM, Taylor DR. Haemopoietic colony stimulating factors promote cell survival by suppressing apoptosis. Nature. 1990;343:76-79.
    • (1990) Nature , vol.343 , pp. 76-79
    • Williams, G.T.1    Smith, C.A.2    Spooncer, E.3    Dexter, T.M.4    Taylor, D.R.5
  • 86
    • 0041856377 scopus 로고    scopus 로고
    • Threonine 391 phosphorylation of the human prolactin receptor mediates a novel interaction with 14-3-3 proteins
    • Olayioye MA, Guthridge MA, Stomski FC, et al. Threonine 391 phosphorylation of the human prolactin receptor mediates a novel interaction with 14-3-3 proteins. J Biol Chem. 2003;278:32929-32935.
    • (2003) J Biol Chem , vol.278 , pp. 32929-32935
    • Olayioye, M.A.1    Guthridge, M.A.2    Stomski, F.C.3
  • 87
    • 34247107080 scopus 로고    scopus 로고
    • Phosphotyrosine/phosphoserine binary switches: A new paradigm for the regulation of PI3K signalling and growth factor pleiotropy?
    • Guthridge MA, Lopez AF. Phosphotyrosine/phosphoserine binary switches: a new paradigm for the regulation of PI3K signalling and growth factor pleiotropy? Biochem Soc Trans. 2007;35:250-252.
    • (2007) Biochem Soc Trans , vol.35 , pp. 250-252
    • Guthridge, M.A.1    Lopez, A.F.2
  • 88
    • 43249088084 scopus 로고    scopus 로고
    • Fibroblast growth factor receptor 2 phosphorylation on serine 779 couples to 14-3-3 and regulates cell survival and proliferation
    • Lonic A, Barry EF, Quach C, et al. Fibroblast growth factor receptor 2 phosphorylation on serine 779 couples to 14-3-3 and regulates cell survival and proliferation. Mol Cell Biol. 2008;28:3372-3385.
    • (2008) Mol Cell Biol , vol.28 , pp. 3372-3385
    • Lonic, A.1    Barry, E.F.2    Quach, C.3
  • 89
    • 36348943571 scopus 로고    scopus 로고
    • The Shc binding site of the βc subunit of the GM-CSF/IL-3/IL-5 receptors is a negative regulator of hematopoiesis
    • Ramshaw HS, Guthridge MA, Stomski FC, et al. The Shc binding site of the βc subunit of the GM-CSF/IL-3/IL-5 receptors is a negative regulator of hematopoiesis. Blood. 2007;110:3582-3590.
    • (2007) Blood , vol.110 , pp. 3582-3590
    • Ramshaw, H.S.1    Guthridge, M.A.2    Stomski, F.C.3
  • 90
    • 66449092365 scopus 로고    scopus 로고
    • 14-3-3: SHC scaffolds integrate phoshoserine and phosphotyrosine signaling to regulate PI 3-kinase activation and cell survival
    • Barry EF, Felquer FA, Powell JA, et al. 14-3-3: SHC scaffolds integrate phoshoserine and phosphotyrosine signaling to regulate PI 3-kinase activation and cell survival. J Biol Chem. 2009;284:12080-12090.
    • (2009) J Biol Chem , vol.284 , pp. 12080-12090
    • Barry, E.F.1    Felquer, F.A.2    Powell, J.A.3
  • 91
    • 0031876318 scopus 로고    scopus 로고
    • Mcl-1 is an immediate-early gene activated by the granulocyte-macrophage colony-stimulating factor (GM-CSF) signalling pathway and is one component of the GM-CSF viability response
    • Chao J-R, Wang T-F, Lee S-F, et al. mcl-1 is an immediate-early gene activated by the granulocyte-macrophage colony-stimulating factor (GM-CSF) signalling pathway and is one component of the GM-CSF viability response. Mol Biol Cell. 1998;18:4883-4898.
    • (1998) Mol Biol Cell , vol.18 , pp. 4883-4898
    • Chao, J.-R.1    Wang, T.-F.2    Lee, S.-F.3
  • 92
    • 33745967414 scopus 로고    scopus 로고
    • Cell death in the absence of Bax and Bak
    • Lindsten T, Thompson CB. Cell death in the absence of Bax and Bak. Cell Death Differ. 2006;13:1272-1276.
    • (2006) Cell Death Differ , vol.13 , pp. 1272-1276
    • Lindsten, T.1    Thompson, C.B.2
  • 93
    • 33747190755 scopus 로고    scopus 로고
    • Cell death provoked by loss of interleukin-3 signaling is independent of Bad, Bim, and PI3 kinase, but depends in part on Puma
    • Ekert PG, Jabbour AM, Manoharan A, et al. Cell death provoked by loss of interleukin-3 signaling is independent of Bad, Bim, and PI3 kinase, but depends in part on Puma. Blood. 2006;108:1461-1468.
    • (2006) Blood , vol.108 , pp. 1461-1468
    • Ekert, P.G.1    Jabbour, A.M.2    Manoharan, A.3
  • 94
    • 33745966804 scopus 로고    scopus 로고
    • BH3-only proteins: Orchestrating cell death
    • Fletcher JI, Huang DC. BH3-only proteins: orchestrating cell death. Cell Death Differ. 2006;13:1268-1271.
    • (2006) Cell Death Differ , vol.13 , pp. 1268-1271
    • Fletcher, J.I.1    Huang, D.C.2
  • 95
    • 0033607506 scopus 로고    scopus 로고
    • Proapoptotic Bcl-2 relative Bim required for certain apoptotic responses, leukocyte homeostasis, and to preclude autoimmunity
    • Bouillet P, Metcalf D, Huang DC, et al. Proapoptotic Bcl-2 relative Bim required for certain apoptotic responses, leukocyte homeostasis, and to preclude autoimmunity. Science. 1999;286:1735-1738.
    • (1999) Science , vol.286 , pp. 1735-1738
    • Bouillet, P.1    Metcalf, D.2    Huang, D.C.3
  • 96
    • 10744228800 scopus 로고    scopus 로고
    • Puma is an essential mediator of p53-dependent and -independent apoptotic pathways
    • Jeffers JR, Parganas E, Lee Y, et al. Puma is an essential mediator of p53-dependent and -independent apoptotic pathways. Cancer Cells. 2003;4:321-328.
    • (2003) Cancer Cells , vol.4 , pp. 321-328
    • Jeffers, J.R.1    Parganas, E.2    Lee, Y.3
  • 97
    • 36048986227 scopus 로고    scopus 로고
    • The BH3-only protein Puma plays an essential role in cytokine deprivation induced apoptosis of mast cells
    • Ekoff M, Kaufmann T, Engstrom M, et al. The BH3-only protein Puma plays an essential role in cytokine deprivation induced apoptosis of mast cells. Blood. 2007;110:3209-3217.
    • (2007) Blood , vol.110 , pp. 3209-3217
    • Ekoff, M.1    Kaufmann, T.2    Engstrom, M.3
  • 98
    • 0030584088 scopus 로고    scopus 로고
    • Serine phosphorylation of death agonist BAD in response to survival factor results in binding to 14-3-3 not bcl-xL
    • Zha J, Harada H, Yang E, Jockel J, Korsmeyer SJ. Serine phosphorylation of death agonist BAD in response to survival factor results in binding to 14-3-3 not bcl-xL. Cell. 1996;87:619-628.
    • (1996) Cell , vol.87 , pp. 619-628
    • Zha, J.1    Harada, H.2    Yang, E.3    Jockel, J.4    Korsmeyer, S.J.5
  • 99
    • 1842333237 scopus 로고    scopus 로고
    • Interleukin-3-induced phosphorylation of Bad through the protein kinase Akt
    • del Peso L, Gonzalez-Garcia M, Page C, Herrera R, Nunez G. Interleukin-3-induced phosphorylation of Bad through the protein kinase Akt. Science. 1997;278:687-689.
    • (1997) Science , vol.278 , pp. 687-689
    • Del Peso, L.1    Gonzalez-Garcia, M.2    Page, C.3    Herrera, R.4    Nunez, G.5
  • 100
    • 23044514254 scopus 로고    scopus 로고
    • Regulatory phosphorylation of Bim: Sorting out the ERK from the JNK
    • Ley R, Ewings KE, Hadfield K, Cook SJ. Regulatory phosphorylation of Bim: sorting out the ERK from the JNK. Cell Death Differ. 2005;12:1008-1014.
    • (2005) Cell Death Differ , vol.12 , pp. 1008-1014
    • Ley, R.1    Ewings, K.E.2    Hadfield, K.3    Cook, S.J.4
  • 101
    • 10744230034 scopus 로고    scopus 로고
    • FoxO3a transcriptional regulation of Bim controls apoptosis in paclitaxel-treated breast cancer cell lines
    • Sunters A, Fernandez de MS, Stahl M, et al. FoxO3a transcriptional regulation of Bim controls apoptosis in paclitaxel-treated breast cancer cell lines. J Biol Chem. 2003;278:49795-49805.
    • (2003) J Biol Chem , vol.278 , pp. 49795-49805
    • Sunters, A.1    De Fernandez, M.S.2    Stahl, M.3
  • 102
    • 33745841375 scopus 로고    scopus 로고
    • FOXO3a-dependent regulation of Puma in response to cytokine/growth factor withdrawal
    • You H, Pellegrini M, Tsuchihara K, et al. FOXO3a-dependent regulation of Puma in response to cytokine/growth factor withdrawal. J Exp Med. 2006;203:1657-1663.
    • (2006) J Exp Med , vol.203 , pp. 1657-1663
    • You, H.1    Pellegrini, M.2    Tsuchihara, K.3
  • 103
    • 33644855216 scopus 로고    scopus 로고
    • Glycogen synthase kinase-3 regulates mitochondrial outer membrane permeabilization and apoptosis by destabilization of MCL-1
    • Maurer U, Charvet C, Wagman AS, Dejardin E, Green DR. Glycogen synthase kinase-3 regulates mitochondrial outer membrane permeabilization and apoptosis by destabilization of MCL-1. Mol Cell. 2006;21:749-760.
    • (2006) Mol Cell , vol.21 , pp. 749-760
    • Maurer, U.1    Charvet, C.2    Wagman, A.S.3    Dejardin, E.4    Green, D.R.5
  • 104
    • 34250179471 scopus 로고    scopus 로고
    • Glycogen synthase kinase 3α and 3β mediate a glucose-sensitive antiapoptotic signaling pathway to stabilize Mcl-1
    • Zhao Y, Altman BJ, Coloff JL, et al. Glycogen synthase kinase 3α and 3β mediate a glucose-sensitive antiapoptotic signaling pathway to stabilize Mcl-1. Mol Cell Biol. 2007;27:4328-4339.
    • (2007) Mol Cell Biol , vol.27 , pp. 4328-4339
    • Zhao, Y.1    Altman, B.J.2    Coloff, J.L.3
  • 105
    • 0036529829 scopus 로고    scopus 로고
    • Transient hematologic and clinical effect of E21R in a child with end-stage juvenile myelomonocytic leukemia
    • Bernard F, Thomas C, Emile JF, et al. Transient hematologic and clinical effect of E21R in a child with end-stage juvenile myelomonocytic leukemia. Blood. 2002;99:2615-2616.
    • (2002) Blood , vol.99 , pp. 2615-2616
    • Bernard, F.1    Thomas, C.2    Emile, J.F.3
  • 106
    • 0032400865 scopus 로고    scopus 로고
    • Diphtheria toxin fused to granulocyte-macrophage colony-stimulating factor is toxic to blasts from patients with juvenile myelomonocytic leukemia and chronic myelomonocytic leukemia
    • Frankel AE, Lilly M, Kreitman R, et al. Diphtheria toxin fused to granulocyte-macrophage colony-stimulating factor is toxic to blasts from patients with juvenile myelomonocytic leukemia and chronic myelomonocytic leukemia. Blood. 1998;92:4279-4286.
    • (1998) Blood , vol.92 , pp. 4279-4286
    • Frankel, A.E.1    Lilly, M.2    Kreitman, R.3
  • 107
    • 0347123433 scopus 로고    scopus 로고
    • Tumor-educated macrophages promote tumor progression and metastasis
    • Pollard JW. Tumor-educated macrophages promote tumor progression and metastasis. Nat Rev Cancer. 2004;4:71-78.
    • (2004) Nat Rev Cancer , vol.4 , pp. 71-78
    • Pollard, J.W.1
  • 108
    • 31044433663 scopus 로고    scopus 로고
    • Macrophages: Obligate partners for tumor cell migration, invasion, and metastasis
    • Condeelis J, Pollard JW. Macrophages: obligate partners for tumor cell migration, invasion, and metastasis. Cell. 2006;124:263-266.
    • (2006) Cell , vol.124 , pp. 263-266
    • Condeelis, J.1    Pollard, J.W.2
  • 109
    • 33751551172 scopus 로고    scopus 로고
    • Dual role of macrophages in tumor growth and angiogenesis
    • Lamagna C, Aurrand-Lions M, Imhof BA. Dual role of macrophages in tumor growth and angiogenesis. J Leukocyte Biol. 2006;80:705-713.
    • (2006) J Leukocyte Biol , vol.80 , pp. 705-713
    • Lamagna, C.1    Aurrand-Lions, M.2    Imhof, B.A.3
  • 110
    • 0034851864 scopus 로고    scopus 로고
    • Blockade of collagen-induced arthritis post-onset by antibody to granulocyte-macrophage colony-stimulating factor (GM-CSF): Requirement for GM-CSF in the effector phase of disease
    • Cook AD, Braine EL, Campbell IK, Rich MJ, Hamilton JA. Blockade of collagen-induced arthritis post-onset by antibody to granulocyte-macrophage colony-stimulating factor (GM-CSF): requirement for GM-CSF in the effector phase of disease. Arthritis Res. 2001;3:293-298.
    • (2001) Arthritis Res , vol.3 , pp. 293-298
    • Cook, A.D.1    Braine, E.L.2    Campbell, I.K.3    Rich, M.J.4    Hamilton, J.A.5
  • 111
    • 0035476518 scopus 로고    scopus 로고
    • Granulocyte macrophage colony-stimulating factor: A new putative therapeutic target in multiple sclerosis
    • McQualter JL, Darwiche R, Ewing C, et al. Granulocyte macrophage colony-stimulating factor: a new putative therapeutic target in multiple sclerosis. J Exp Med. 2001;194:873-882.
    • (2001) J Exp Med , vol.194 , pp. 873-882
    • McQualter, J.L.1    Darwiche, R.2    Ewing, C.3
  • 112
    • 0037044696 scopus 로고    scopus 로고
    • Local delivery of granulocyte macrophage colony-stimulating factor by retrovirally transduced antigen-specific T cells leads to severe, chronic experimental autoimmune encephalomyelitis in mice
    • Marusic S, Miyashiro JS, Douhan J, III, et al. Local delivery of granulocyte macrophage colony-stimulating factor by retrovirally transduced antigen-specific T cells leads to severe, chronic experimental autoimmune encephalomyelitis in mice. Neurosci Lett. 2002;332:185-189.
    • (2002) Neurosci Lett , vol.332 , pp. 185-189
    • Marusic, S.1    Miyashiro, J.S.2    Douhan III, J.3
  • 113
    • 33846018916 scopus 로고    scopus 로고
    • GMCSF production by autoreactive T cells is required for the activation of microglial cells and the onset of experimental autoimmune encephalomyelitis
    • Ponomarev ED, Shriver LP, Maresz K, et al. GMCSF production by autoreactive T cells is required for the activation of microglial cells and the onset of experimental autoimmune encephalomyelitis. J Immunol. 2007;178:39-48.
    • (2007) J Immunol , vol.178 , pp. 39-48
    • Ponomarev, E.D.1    Shriver, L.P.2    Maresz, K.3
  • 114
    • 0036154058 scopus 로고    scopus 로고
    • The requirement for granulocyte-macrophage colony-stimulating factor and granulocyte colony-stimulating factor in leukocyte-mediated immune glomerular injury
    • Kitching AR, Ru Huang X, Turner AL, et al. The requirement for granulocyte-macrophage colony-stimulating factor and granulocyte colony-stimulating factor in leukocyte-mediated immune glomerular injury. J Am Soc Nephrol. 2002;13:350-358.
    • (2002) J Am Soc Nephrol , vol.13 , pp. 350-358
    • Kitching, A.R.1    Ru Huang, X.2    Turner, A.L.3
  • 115
    • 33644814617 scopus 로고    scopus 로고
    • Granulocyte macrophage colony-stimulating factor expression by both renal parenchymal and immune cells mediates murine crescentic glomerulonephritis
    • Timoshanko JR, Kitching AR, Semple TJ, Holdsworth SR, Tipping PG. Granulocyte macrophage colony-stimulating factor expression by both renal parenchymal and immune cells mediates murine crescentic glomerulonephritis. J Am Soc Nephrol. 2005;16:2646-2656.
    • (2005) J Am Soc Nephrol , vol.16 , pp. 2646-2656
    • Timoshanko, J.R.1    Kitching, A.R.2    Semple, T.J.3    Holdsworth, S.R.4    Tipping, P.G.5
  • 116
    • 0033815950 scopus 로고    scopus 로고
    • The interleukin-3 receptor α chain is a unique marker for human acute myelogenous leukemia stem cells
    • Jordan CT, Upchurch D, Szilvassy SJ, et al. The interleukin-3 receptor α chain is a unique marker for human acute myelogenous leukemia stem cells. Leukemia. 2000;14:1777-1784.
    • (2000) Leukemia , vol.14 , pp. 1777-1784
    • Jordan, C.T.1    Upchurch, D.2    Szilvassy, S.J.3
  • 117
    • 0035662980 scopus 로고    scopus 로고
    • Interleukin-3 receptor α chain (CD123) is widely expressed in hematologic malignancies
    • Muñoz L, Nomdedeu JF, Lopez O, et al. Interleukin-3 receptor α chain (CD123) is widely expressed in hematologic malignancies. Haematologica. 2001;86:1261-1269.
    • (2001) Haematologica , vol.86 , pp. 1261-1269
    • Muñoz, L.1    Nomdedeu, J.F.2    Lopez, O.3
  • 118
    • 0742286841 scopus 로고    scopus 로고
    • Expression and prognostic value of hemopoietic cytokine receptors in acute myeloid leukemia (AML): Implications for future therapeutical strategies
    • Graf M, Hecht K, Reif S, et al. Expression and prognostic value of hemopoietic cytokine receptors in acute myeloid leukemia (AML): implications for future therapeutical strategies. Eur J Haematol. 2004;72:89-106.
    • (2004) Eur J Haematol , vol.72 , pp. 89-106
    • Graf, M.1    Hecht, K.2    Reif, S.3
  • 119
    • 61949250521 scopus 로고    scopus 로고
    • CD123 (IL-3 receptor α chain) neutralization by a monoclonal antibody selectively eliminates human acute myeloid leukemic stem cells
    • Lock RB, Jin L, Lee EM, et al. CD123 (IL-3 receptor α chain) neutralization by a monoclonal antibody selectively eliminates human acute myeloid leukemic stem cells. Blood (ASH Annual Meeting Abstracts). 2007;110:161.
    • (2007) Blood (ASH Annual Meeting Abstracts) , vol.110 , pp. 161
    • Lock, R.B.1    Jin, L.2    Lee, E.M.3
  • 120
    • 70449505678 scopus 로고    scopus 로고
    • A phase 1 and correlative biological study of CSL360 (anti-CD123 mAb) in AML
    • Roberts AW, He S, Bradstock KF, et al. A phase 1 and correlative biological study of CSL360 (anti-CD123 mAb) in AML. Blood (ASH Annual Meeting Abstracts). 2008;112:2956.
    • (2008) Blood (ASH Annual Meeting Abstracts) , vol.112 , pp. 2956
    • Roberts, A.W.1    He, S.2    Bradstock, K.F.3
  • 121
    • 40949146020 scopus 로고    scopus 로고
    • Treatment of patients with the hypereosinophilic syndrome with mepolizumab
    • Rothenberg ME, Klion AD, Roufosse FE, et al. Treatment of patients with the hypereosinophilic syndrome with mepolizumab. N Engl J Med. 2008;358:1215-1228.
    • (2008) N Engl J Med , vol.358 , pp. 1215-1228
    • Rothenberg, M.E.1    Klion, A.D.2    Roufosse, F.E.3
  • 122
    • 61849155730 scopus 로고    scopus 로고
    • Mepolizumab for prednisone-dependent asthma with sputum eosinophilia
    • Nair P, Pizzichini MM, Kjarsgaard M, et al. Mepolizumab for prednisone-dependent asthma with sputum eosinophilia. N Engl J Med. 2009;360:985-993.
    • (2009) N Engl J Med , vol.360 , pp. 985-993
    • Nair, P.1    Pizzichini, M.M.2    Kjarsgaard, M.3
  • 123
    • 61849086181 scopus 로고    scopus 로고
    • Mepolizumab and exacerbations of refractory eosinophilic asthma
    • Haldar P, Brightling CE, Hargadon B, et al. Mepolizumab and exacerbations of refractory eosinophilic asthma. N Engl J Med. 2009;360:973-984.
    • (2009) N Engl J Med , vol.360 , pp. 973-984
    • Haldar, P.1    Brightling, C.E.2    Hargadon, B.3
  • 124
    • 0036826485 scopus 로고    scopus 로고
    • Attenuation of airway hyperresponsiveness in a murine asthma model by neutralization of granulocyte-macrophage colony-stimulating factor (GM-CSF)
    • Yamashita N, Tashimo H, Ishida H, et al. Attenuation of airway hyperresponsiveness in a murine asthma model by neutralization of granulocyte-macrophage colony-stimulating factor (GM-CSF). Cell Immunol. 2002;219:92-97.
    • (2002) Cell Immunol , vol.219 , pp. 92-97
    • Yamashita, N.1    Tashimo, H.2    Ishida, H.3
  • 125
    • 0037044792 scopus 로고    scopus 로고
    • Granulocyte/Macrophage-colony-stimulating factor (GM-CSF) regulates lung innate immunity to lipopolysaccharide through Akt/Erk activation of NFκB and AP-1 in vivo
    • Bozinovski S, Jones JE, Vlahos R, Hamilton JA, Anderson GP. Granulocyte/Macrophage-colony-stimulating factor (GM-CSF) regulates lung innate immunity to lipopolysaccharide through Akt/Erk activation of NFκB and AP-1 in vivo. J Biol Chem. 2002;277:42808-42814.
    • (2002) J Biol Chem , vol.277 , pp. 42808-42814
    • Bozinovski, S.1    Jones, J.E.2    Vlahos, R.3    Hamilton, J.A.4    Anderson, G.P.5
  • 126
    • 33748053351 scopus 로고    scopus 로고
    • Therapeutic potential of treating chronic obstructive pulmonary disease (COPD) by neutralizing granulocyte macrophage-colony stimulating factor (GM-CSF)
    • Vlahos R, Bozinovski S, Hamilton JA, Anderson GP. Therapeutic potential of treating chronic obstructive pulmonary disease (COPD) by neutralizing granulocyte macrophage-colony stimulating factor (GM-CSF). Pharmacol Ther. 2006;112:106-115.
    • (2006) Pharmacol Ther , vol.112 , pp. 106-115
    • Vlahos, R.1    Bozinovski, S.2    Hamilton, J.A.3    Anderson, G.P.4
  • 127
    • 40449117731 scopus 로고    scopus 로고
    • The IL-3/IL-5/GM-CSF common receptor plays a pivotal role in the regulation of Th2 immunity and allergic airway inflammation
    • Asquith KL, Ramshaw HS, Hansbro PM, et al. The IL-3/IL-5/GM-CSF common receptor plays a pivotal role in the regulation of Th2 immunity and allergic airway inflammation. J Immunol. 2008;180:1199-1206.
    • (2008) J Immunol , vol.180 , pp. 1199-1206
    • Asquith, K.L.1    Ramshaw, H.S.2    Hansbro, P.M.3
  • 128
    • 54349086521 scopus 로고    scopus 로고
    • Mutations of JAK2 in acute lymphoblastic leukemias associated with Down's syndrome
    • Bercovich D, Ganmore I, Scott LM, et al. Mutations of JAK2 in acute lymphoblastic leukemias associated with Down's syndrome. Lancet. 2008;372:1484-1492.
    • (2008) Lancet , vol.372 , pp. 1484-1492
    • Bercovich, D.1    Ganmore, I.2    Scott, L.M.3
  • 129
    • 43549109620 scopus 로고    scopus 로고
    • The Jak2V617F oncogene associated with myeloproliferative diseases requires a functional FERM domain for transformation and for expression of the Myc and Pim proto-oncogenes
    • Wernig G, Gonneville JR, Crowley BJ, et al. The Jak2V617F oncogene associated with myeloproliferative diseases requires a functional FERM domain for transformation and for expression of the Myc and Pim proto-oncogenes. Blood. 2008;111:3751-3759.
    • (2008) Blood , vol.111 , pp. 3751-3759
    • Wernig, G.1    Gonneville, J.R.2    Crowley, B.J.3
  • 130
    • 30044437118 scopus 로고    scopus 로고
    • Expression of a homodimeric type I cytokine receptor is required for JAK2V617F-mediated transformation
    • Lu X, Levine R, Tong W, et al. Expression of a homodimeric type I cytokine receptor is required for JAK2V617F-mediated transformation. Proc Natl Acad Sci U S A. 2005;102:18962-18967.
    • (2005) Proc Natl Acad Sci U S A , vol.102 , pp. 18962-18967
    • Lu, X.1    Levine, R.2    Tong, W.3
  • 131
    • 41949118675 scopus 로고    scopus 로고
    • Dimerization by a cytokine receptor is necessary for constitutive activation of JAK2V617F
    • Lu X, Huang LJ, Lodish HF. Dimerization by a cytokine receptor is necessary for constitutive activation of JAK2V617F. J Biol Chem. 2008;283:5258-5266.
    • (2008) J Biol Chem , vol.283 , pp. 5258-5266
    • Lu, X.1    Huang, L.J.2    Lodish, H.F.3
  • 132
    • 0026667283 scopus 로고
    • Polycythemia vera. II. Hypersensitivity of bone marrow erythroid, granulocyte-macrophage, and megakaryocyte progenitor cells to interleukin-3 and granulocyte-macrophage colony-stimulating factor
    • Dai CH, Krantz SB, Dessypris EN, et al. Polycythemia vera. II. Hypersensitivity of bone marrow erythroid, granulocyte-macrophage, and megakaryocyte progenitor cells to interleukin-3 and granulocyte-macrophage colony-stimulating factor. Blood. 1992;80:891-899.
    • (1992) Blood , vol.80 , pp. 891-899
    • Dai, C.H.1    Krantz, S.B.2    Dessypris, E.N.3
  • 133
    • 0034651043 scopus 로고    scopus 로고
    • Inhibition of juvenile myelomonocytic leukemia cell growth in vitro by farnesyltransferase inhibitors
    • Emanuel PD, Snyder RC, Wiley T, Gopurala B, Castleberry RP. Inhibition of juvenile myelomonocytic leukemia cell growth in vitro by farnesyltransferase inhibitors. Blood. 2000;95:639-645.
    • (2000) Blood , vol.95 , pp. 639-645
    • Emanuel, P.D.1    Snyder, R.C.2    Wiley, T.3    Gopurala, B.4    Castleberry, R.P.5
  • 134
    • 0036090222 scopus 로고    scopus 로고
    • Primitive, quiescent, Philadelphia-positive stem cells from patients with chronic myeloid leukemia are insensitive to STI571 in vitro
    • Graham SM, Jorgensen HG, Allan E, et al. Primitive, quiescent, Philadelphia-positive stem cells from patients with chronic myeloid leukemia are insensitive to STI571 in vitro. Blood. 2002;99:319-325.
    • (2002) Blood , vol.99 , pp. 319-325
    • Graham, S.M.1    Jorgensen, H.G.2    Allan, E.3
  • 135
    • 43749122581 scopus 로고    scopus 로고
    • BCR-ABL oncogenic transformation of NIH 3T3 fibroblasts requires the IL-3 receptor
    • Tao WJ, Lin H, Sun T, Samanta AK, Arlinghaus R. BCR-ABL oncogenic transformation of NIH 3T3 fibroblasts requires the IL-3 receptor. Oncogene. 2008;27:3194-3200.
    • (2008) Oncogene , vol.27 , pp. 3194-3200
    • Tao, W.J.1    Lin, H.2    Sun, T.3    Samanta, A.K.4    Arlinghaus, R.5
  • 136
    • 38049187096 scopus 로고    scopus 로고
    • Mammalian target of rapamycin (mTOR) inhibition activates phosphatidylinositol 3-kinase/Akt by upregulating insulin-like growth factor-1 receptor signaling in acute myeloid leukemia: Rationale for therapeutic inhibition of both pathways
    • Tamburini J, Chapuis N, Bardet V, et al. Mammalian target of rapamycin (mTOR) inhibition activates phosphatidylinositol 3-kinase/Akt by upregulating insulin-like growth factor-1 receptor signaling in acute myeloid leukemia: rationale for therapeutic inhibition of both pathways. Blood. 2008;111:379-382.
    • (2008) Blood , vol.111 , pp. 379-382
    • Tamburini, J.1    Chapuis, N.2    Bardet, V.3
  • 137
    • 22544444889 scopus 로고    scopus 로고
    • Essential role for the p110 isoform in phosphoinositide 3-kinase activation and cell proliferation in acute myeloid leukemia
    • Sujobert P, Bardet V, Cornillet-Lefebvre P, et al. Essential role for the p110 isoform in phosphoinositide 3-kinase activation and cell proliferation in acute myeloid leukemia. Blood. 2005;106:1063-1066.
    • (2005) Blood , vol.106 , pp. 1063-1066
    • Sujobert, P.1    Bardet, V.2    Cornillet-Lefebvre, P.3
  • 138
    • 34547932268 scopus 로고    scopus 로고
    • Constitutive phosphoinositide 3-kinase/Akt activation represents a favorable prognostic factor in de novo acute myelogenous leukemia patients
    • Tamburini J, Elie C, Bardet V, et al. Constitutive phosphoinositide 3-kinase/Akt activation represents a favorable prognostic factor in de novo acute myelogenous leukemia patients. Blood. 2007;110:1025-1028.
    • (2007) Blood , vol.110 , pp. 1025-1028
    • Tamburini, J.1    Elie, C.2    Bardet, V.3
  • 139
    • 55349109688 scopus 로고    scopus 로고
    • Pathways to cancer therapy
    • Jones D. Pathways to cancer therapy. Nat Rev Drug Discov. 2008;7:875-876.
    • (2008) Nat Rev Drug Discov , vol.7 , pp. 875-876
    • Jones, D.1
  • 140
    • 0021821903 scopus 로고
    • Involvement of the bcl-2 gene in human follicular lymphoma
    • Tsujimoto Y, Cossman J, Jaffe E, Croce CM. Involvement of the bcl-2 gene in human follicular lymphoma. Science. 1985;228:1440-1443.
    • (1985) Science , vol.228 , pp. 1440-1443
    • Tsujimoto, Y.1    Cossman, J.2    Jaffe, E.3    Croce, C.M.4
  • 141
    • 0346492579 scopus 로고    scopus 로고
    • Apaf-1 and caspase-9 do not act as tumor suppressors in myc-induced lymphomagenesis or mouse embryo fibroblast transformation
    • Scott CL, Schuler M, Marsden VS, et al. Apaf-1 and caspase-9 do not act as tumor suppressors in myc-induced lymphomagenesis or mouse embryo fibroblast transformation. J Cell Biol. 2004;164:89-96.
    • (2004) J Cell Biol , vol.164 , pp. 89-96
    • Scott, C.L.1    Schuler, M.2    Marsden, V.S.3
  • 143
    • 60849086456 scopus 로고    scopus 로고
    • Bcl-2 inhibitors: Small molecules with a big impact on cancer therapy
    • Vogler M, Dinsdale D, Dyer MJ, Cohen GM. Bcl-2 inhibitors: small molecules with a big impact on cancer therapy. Cell Death Differ. 2009;16:360-367.
    • (2009) Cell Death Differ , vol.16 , pp. 360-367
    • Vogler, M.1    Dinsdale, D.2    Dyer, M.J.3    Cohen, G.M.4
  • 144


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.