-
1
-
-
38349157811
-
Hematopoietic cytokines
-
Metcalf D. Hematopoietic cytokines. Blood. 2008;111:485-491.
-
(2008)
Blood
, vol.111
, pp. 485-491
-
-
Metcalf, D.1
-
2
-
-
0035838984
-
Dendritic cells: Specialized and regulated antigen processing machines
-
Mellman I, Steinman RM. Dendritic cells: specialized and regulated antigen processing machines. Cell. 2001;106:255-258.
-
(2001)
Cell
, vol.106
, pp. 255-258
-
-
Mellman, I.1
Steinman, R.M.2
-
3
-
-
0032529495
-
Defective expression of granulocyte-macrophage colony-stimulating factor/interleukin-3/interleukin-5 receptor common β chain in children with acute myeloid leukemia associated with respiratory failure
-
Dirksen U, Hattenhorst U, Schneider P, et al. Defective expression of granulocyte-macrophage colony-stimulating factor/interleukin-3/interleukin-5 receptor common β chain in children with acute myeloid leukemia associated with respiratory failure. Blood. 1998;92:1097-1103.
-
(1998)
Blood
, vol.92
, pp. 1097-1103
-
-
Dirksen, U.1
Hattenhorst, U.2
Schneider, P.3
-
4
-
-
0028263504
-
Involvement of granulocyte-macrophage colonystimulating factor in pulmonary homeostasis
-
Dranoff G, Crawford AD, Sadelain M, et al. Involvement of granulocyte-macrophage colonystimulating factor in pulmonary homeostasis. Science. 1994;264:713-716.
-
(1994)
Science
, vol.264
, pp. 713-716
-
-
Dranoff, G.1
Crawford, A.D.2
Sadelain, M.3
-
5
-
-
9144247674
-
High-affinity autoantibodies specifically eliminate granulocyte- macrophage colony-stimulating factor activity in the lungs of patients with idiopathic pulmonary alveolar proteinosis
-
Uchida K, Nakata K, Trapnell BC, et al. High-affinity autoantibodies specifically eliminate granulocyte-macrophage colony-stimulating factor activity in the lungs of patients with idiopathic pulmonary alveolar proteinosis. Blood. 2004;103:1089-1098.
-
(2004)
Blood
, vol.103
, pp. 1089-1098
-
-
Uchida, K.1
Nakata, K.2
Trapnell, B.C.3
-
6
-
-
58149316253
-
Pulmonary alveolar proteinosis caused by deletion of the GM-CSFRα gene in the X chromosome pseudoautosomal region 1
-
Martinez-Moczygemba M, Doan ML, Elidemir O, et al. Pulmonary alveolar proteinosis caused by deletion of the GM-CSFRα gene in the X chromosome pseudoautosomal region 1. J Exp Med. 2008;205:2711-2716.
-
(2008)
J Exp Med
, vol.205
, pp. 2711-2716
-
-
Martinez-Moczygemba, M.1
Doan, M.L.2
Elidemir, O.3
-
7
-
-
58149313016
-
Familial pulmonary alveolar proteinosis caused by mutations in CSF2RA
-
Suzuki T, Sakagami T, Rubin BK, et al. Familial pulmonary alveolar proteinosis caused by mutations in CSF2RA. J Exp Med. 2008;205:2703-2710.
-
(2008)
J Exp Med
, vol.205
, pp. 2703-2710
-
-
Suzuki, T.1
Sakagami, T.2
Rubin, B.K.3
-
8
-
-
0028236526
-
Granulocyte-macrophage colony-stimulating factor-deficient mice show no major perturbation of hematopoiesis but develop a characteristic pulmonary pathology
-
Stanley E, Lieschke GJ, Grail D, et al. Granulocyte-macrophage colony-stimulating factor-deficient mice show no major perturbation of hematopoiesis but develop a characteristic pulmonary pathology. Proc Natl Acad Sci U S A. 1994;91:5592-5596.
-
(1994)
Proc Natl Acad Sci U S A
, vol.91
, pp. 5592-5596
-
-
Stanley, E.1
Lieschke, G.J.2
Grail, D.3
-
9
-
-
0028824907
-
Hematopoietic and lung abnormalities in mice with a null mutation of the common β subunit of the receptors for granulocyte-macrophage colony-stimulating factor and interleukins 3 and 5
-
Robb L, Drinkwater CC, Metcalf D, et al. Hematopoietic and lung abnormalities in mice with a null mutation of the common β subunit of the receptors for granulocyte-macrophage colony-stimulating factor and interleukins 3 and 5. Proc Natl Acad Sci U S A. 1995;92:9565-9569.
-
(1995)
Proc Natl Acad Sci U S A
, vol.92
, pp. 9565-9569
-
-
Robb, L.1
Drinkwater, C.C.2
Metcalf, D.3
-
10
-
-
0025881348
-
Granulocyte-macrophage colony-stimulating factor promotes the proliferation of human alveolar macrophages in vitro
-
Nakata K, Akagawa KS, Fukayama M, et al. Granulocyte-macrophage colony-stimulating factor promotes the proliferation of human alveolar macrophages in vitro. J Immunol. 1991;147:1266-1272.
-
(1991)
J Immunol
, vol.147
, pp. 1266-1272
-
-
Nakata, K.1
Akagawa, K.S.2
Fukayama, M.3
-
11
-
-
33947716601
-
IL-3 can not replace GM-CSF in inducing human monocytes to differentiate into Langerhans cells
-
Shibasaki T, Katayama N, Ohishi K, et al. IL-3 can not replace GM-CSF in inducing human monocytes to differentiate into Langerhans cells. Int J Oncol. 2007;30:549-555.
-
(2007)
Int J Oncol
, vol.30
, pp. 549-555
-
-
Shibasaki, T.1
Katayama, N.2
Ohishi, K.3
-
12
-
-
30344449182
-
Functions of granulocyte-macrophage colony-stimulating factor
-
Fleetwood AJ, Cook AD, Hamilton JA. Functions of granulocyte-macrophage colony-stimulating factor. Crit Rev Immunol. 2005;25:405-428.
-
(2005)
Crit Rev Immunol
, vol.25
, pp. 405-428
-
-
Fleetwood, A.J.1
Cook, A.D.2
Hamilton, J.A.3
-
14
-
-
47649104857
-
Juvenile myelomonocytic leukemia and chronic myelomonocytic leukemia
-
Emanuel PD. Juvenile myelomonocytic leukemia and chronic myelomonocytic leukemia. Leukemia. 2008;22:1335-1342.
-
(2008)
Leukemia
, vol.22
, pp. 1335-1342
-
-
Emanuel, P.D.1
-
15
-
-
0026063878
-
Selective hypersensitivity to granulocyte-macrophage colony-stimulating factor by juvenile chronic myeloid leukemia hematopoietic progenitors
-
Emanuel PD, Bates LJ, Castleberry RP, Gualtieri RJ, Zucherman KS. Selective hypersensitivity to granulocyte-macrophage colony-stimulating factor by juvenile chronic myeloid leukemia hematopoietic progenitors. Blood. 1991;77:925-929.
-
(1991)
Blood
, vol.77
, pp. 925-929
-
-
Emanuel, P.D.1
Bates, L.J.2
Castleberry, R.P.3
Gualtieri, R.J.4
Zucherman, K.S.5
-
16
-
-
0030925139
-
Deoxyribonucleic acid triplex formation inhibits granulocyte macrophage colony-stimulating factor gene expression and suppresses growth in juvenile myelomonocytic leukemic cells
-
Kochetkova M, Iversen PO, Lopez AF, Shannon MF. Deoxyribonucleic acid triplex formation inhibits granulocyte macrophage colony-stimulating factor gene expression and suppresses growth in juvenile myelomonocytic leukemic cells. J Clin Invest. 1997;99:3000-3008.
-
(1997)
J Clin Invest
, vol.99
, pp. 3000-3008
-
-
Kochetkova, M.1
Iversen, P.O.2
Lopez, A.F.3
Shannon, M.F.4
-
17
-
-
0033982718
-
Nf1 and Gmcsf interact in myeloid leukemogenesis
-
Birnbaum RA, O'Marcaigh A, Wardak Z, et al. Nf1 and Gmcsf interact in myeloid leukemogenesis. Mol Cell. 2000;5:189-195.
-
(2000)
Mol Cell
, vol.5
, pp. 189-195
-
-
Birnbaum, R.A.1
O'Marcaigh, A.2
Wardak, Z.3
-
18
-
-
33846902274
-
Beta common receptor inactivation attenuates myeloproliferative disease in Nf1 mutant mice
-
Kim A, Morgan K, Hasz DE, et al. Beta common receptor inactivation attenuates myeloproliferative disease in Nf1 mutant mice. Blood. 2007;109:1687-1691.
-
(2007)
Blood
, vol.109
, pp. 1687-1691
-
-
Kim, A.1
Morgan, K.2
Hasz, D.E.3
-
19
-
-
0036789943
-
Chronic myelomonocytic leukemia requires granulocyte-macrophage colony-stimulating factor for growth in vitro and in vivo
-
Ramshaw HS, Bardy PG, Lee M, Lopez AF. Chronic myelomonocytic leukemia requires granulocyte-macrophage colony-stimulating factor for growth in vitro and in vivo. Exp Hematol. 2002;30:1124-1131.
-
(2002)
Exp Hematol
, vol.30
, pp. 1124-1131
-
-
Ramshaw, H.S.1
Bardy, P.G.2
Lee, M.3
Lopez, A.F.4
-
20
-
-
33744457651
-
Molecular basis of the diagnosis and treatment of polycythemia vera and essential thrombocythemia
-
Schafer AI. Molecular basis of the diagnosis and treatment of polycythemia vera and essential thrombocythemia. Blood. 2006;107:4214-4222.
-
(2006)
Blood
, vol.107
, pp. 4214-4222
-
-
Schafer, A.I.1
-
21
-
-
0011134388
-
RAS gene mutations in acute and chronic myelocytic leukemias, chronic myeloproliferative disorders, and myelodysplastic syndromes
-
Janssen JW, Steenvoorden AC, Lyons J, et al. RAS gene mutations in acute and chronic myelocytic leukemias, chronic myeloproliferative disorders, and myelodysplastic syndromes. Proc Natl Acad Sci U S A. 1987;84:9228-9232.
-
(1987)
Proc Natl Acad Sci U S A
, vol.84
, pp. 9228-9232
-
-
Janssen, J.W.1
Steenvoorden, A.C.2
Lyons, J.3
-
22
-
-
32544439898
-
Growth factor pleiotropy is controlled by a receptor Tyr/Ser motif that acts as a binary switch
-
Guthridge MA, Powell JA, Barry EF, et al. Growth factor pleiotropy is controlled by a receptor Tyr/Ser motif that acts as a binary switch. EMBO J. 2006;25:479-489.
-
(2006)
EMBO J
, vol.25
, pp. 479-489
-
-
Guthridge, M.A.1
Powell, J.A.2
Barry, E.F.3
-
23
-
-
0029680564
-
P210 Bcr-Abl interacts with the interleukin 3 receptor β (c) subunit and constitutively induces its tyrosine phosphorylation
-
Wilson-Rawls J, Xie S, Liu J, Laneuville P, Arlinghaus RB. P210 Bcr-Abl interacts with the interleukin 3 receptor β (c) subunit and constitutively induces its tyrosine phosphorylation. Cancer Res. 1996;56:3426-3430.
-
(1996)
Cancer Res
, vol.56
, pp. 3426-3430
-
-
Wilson-Rawls, J.1
Xie, S.2
Liu, J.3
Laneuville, P.4
Arlinghaus, R.B.5
-
24
-
-
17844383458
-
A unique clonal JAK2 mutation leading to constitutive signalling causes polycythaemia vera
-
James C, Ugo V, Le Couedic JP, et al. A unique clonal JAK2 mutation leading to constitutive signalling causes polycythaemia vera. Nature. 2005;434:1144-1148.
-
(2005)
Nature
, vol.434
, pp. 1144-1148
-
-
James, C.1
Ugo, V.2
Le Couedic, J.P.3
-
25
-
-
46249090513
-
Colony-stimulating factors in inflammation and autoimmunity
-
Hamilton JA. Colony-stimulating factors in inflammation and autoimmunity. Nat Rev Immunol. 2008;8:533-544.
-
(2008)
Nat Rev Immunol
, vol.8
, pp. 533-544
-
-
Hamilton, J.A.1
-
26
-
-
34250817984
-
Administration of cyclooxygenase-2 inhibitor reduces joint inflammation but exacerbates osteopenia in IL-1α transgenic mice due to GM-CSF overproduction
-
Niki Y, Takaishi H, Takito J, et al. Administration of cyclooxygenase-2 inhibitor reduces joint inflammation but exacerbates osteopenia in IL-1α transgenic mice due to GM-CSF overproduction. J Immunol. 2007;179:639-646.
-
(2007)
J Immunol
, vol.179
, pp. 639-646
-
-
Niki, Y.1
Takaishi, H.2
Takito, J.3
-
27
-
-
0030744451
-
Granulocyte-macrophage colony stimulating factor exacerbates collagen induced arthritis in mice
-
Campbell IK, Bendele A, Smith DA, Hamilton JA. Granulocyte-macrophage colony stimulating factor exacerbates collagen induced arthritis in mice. Ann Rheum Dis. 1997;56:364-368.
-
(1997)
Ann Rheum Dis
, vol.56
, pp. 364-368
-
-
Campbell, I.K.1
Bendele, A.2
Smith, D.A.3
Hamilton, J.A.4
-
28
-
-
0032193230
-
Protection from collagen-induced arthritis in granulocyte-macrophage colony-stimulating factor-deficient mice
-
Campbell IK, Rich MJ, Bischof RJ, et al. Protection from collagen-induced arthritis in granulocyte-macrophage colony-stimulating factor-deficient mice. J Immunol. 1998;161:3639-3644.
-
(1998)
J Immunol
, vol.161
, pp. 3639-3644
-
-
Campbell, I.K.1
Rich, M.J.2
Bischof, R.J.3
-
29
-
-
0022049874
-
Specific binding of radio-iodinated granulocyte-macrophage colony-stimulating factor to hemopoietic cells
-
Walker F, Burgess AW. Specific binding of radio-iodinated granulocyte-macrophage colony-stimulating factor to hemopoietic cells. EMBO J 1985;4:933-939.
-
(1985)
EMBO J
, vol.4
, pp. 933-939
-
-
Walker, F.1
Burgess, A.W.2
-
30
-
-
0022443639
-
Characterization of the cell surface receptor for human granulocyte/macrophage colony-stimulating factor
-
Park LS, Friend D, Gillis S, Urdal DL. Characterization of the cell surface receptor for human granulocyte/macrophage colony-stimulating factor. J Exp Med. 1986;164:251-262.
-
(1986)
J Exp Med
, vol.164
, pp. 251-262
-
-
Park, L.S.1
Friend, D.2
Gillis, S.3
Urdal, D.L.4
-
31
-
-
0024846310
-
Expression cloning of a receptor for human granulocyte-macrophage colony-stimulating factor
-
Gearing DP, King JA, Gough NM, Nicola NA. Expression cloning of a receptor for human granulocyte-macrophage colony-stimulating factor. EMBO J. 1989;8:3667-3676.
-
(1989)
EMBO J
, vol.8
, pp. 3667-3676
-
-
Gearing, D.P.1
King, J.A.2
Gough, N.M.3
Nicola, N.A.4
-
32
-
-
0025637605
-
Molecular cloning of a second subunit of the receptor for human granulocyte-macrophage colony-stimulating factor (GM-CSF): Reconstitution of a high-affinity GM-CSF receptor
-
Hayashida K, Kitamura T, Gorman DM, et al. Molecular cloning of a second subunit of the receptor for human granulocyte-macrophage colony-stimulating factor (GM-CSF): reconstitution of a high-affinity GM-CSF receptor. Proc Natl Acad Sci U S A. 1990;87:9655-9659.
-
(1990)
Proc Natl Acad Sci U S A
, vol.87
, pp. 9655-9659
-
-
Hayashida, K.1
Kitamura, T.2
Gorman, D.M.3
-
33
-
-
0024549443
-
Nonhematopoietic tumor cells express functional GMC-SF receptors
-
Baldwin G, Gasson J, Kaufman S, et al. Nonhematopoietic tumor cells express functional GMC-SF receptors. Blood. 1989;73:1033-1037.
-
(1989)
Blood
, vol.73
, pp. 1033-1037
-
-
Baldwin, G.1
Gasson, J.2
Kaufman, S.3
-
34
-
-
0001367781
-
Human granulocyte-macrophage colony-stimulating factor is a growth factor active on a variety of cell types of nonhemopoietic origin
-
Dedhar S, Gaboury L, Galloway P, Eaves C. Human granulocyte-macrophage colony-stimulating factor is a growth factor active on a variety of cell types of nonhemopoietic origin. Proc Natl Acad Sci U S A. 1988;85:9253-9257.
-
(1988)
Proc Natl Acad Sci U S A
, vol.85
, pp. 9253-9257
-
-
Dedhar, S.1
Gaboury, L.2
Galloway, P.3
Eaves, C.4
-
35
-
-
0024531796
-
Granulocyte- and granulocyte-macrophage-colony stimulating factors induce human endothelial cells to migrate and proliferate
-
Bussolino F, Wang JM, Defilippi P, et al. Granulocyte- and granulocyte-macrophage-colony stimulating factors induce human endothelial cells to migrate and proliferate. Nature. 1989;337:471-473.
-
(1989)
Nature
, vol.337
, pp. 471-473
-
-
Bussolino, F.1
Wang, J.M.2
Defilippi, P.3
-
36
-
-
0032006883
-
Expression of granulocyte-macrophage colony-stimulating factor receptors in human prostate cancer
-
Rivas CI, Vera JC, Delgado-Lopez F, et al. Expression of granulocyte-macrophage colony-stimulating factor receptors in human prostate cancer. Blood. 1998;91:1037-1043.
-
(1998)
Blood
, vol.91
, pp. 1037-1043
-
-
Rivas, C.I.1
Vera, J.C.2
Delgado-Lopez, F.3
-
37
-
-
0033970452
-
Novel murine myeloid cell lines that exhibit a differentiation switch in response to IL-3 or GM-CSF, or to different constitutively active mutants of the GM-CSF receptor β subunit
-
McCormack MP, Gonda TJ. Novel murine myeloid cell lines that exhibit a differentiation switch in response to IL-3 or GM-CSF, or to different constitutively active mutants of the GM-CSF receptor β subunit. Blood. 2000;95:120-127.
-
(2000)
Blood
, vol.95
, pp. 120-127
-
-
McCormack, M.P.1
Gonda, T.J.2
-
38
-
-
58149151542
-
IL-3 induces a Pim1-dependent antiapoptotic pathway in primary human basophils
-
Didichenko SA, Spiegl N, Brunner T, Dahinden CA. IL-3 induces a Pim1-dependent antiapoptotic pathway in primary human basophils. Blood. 2008;112:3949-3958.
-
(2008)
Blood
, vol.112
, pp. 3949-3958
-
-
Didichenko, S.A.1
Spiegl, N.2
Brunner, T.3
Dahinden, C.A.4
-
39
-
-
48449102092
-
The structure of the GM-CSF receptor complex reveals a distinct mode of cytokine receptor assembly
-
Hansen G, Hercus TR, McClure BJ, et al. The structure of the GM-CSF receptor complex reveals a distinct mode of cytokine receptor assembly. Cell. 2008;134:496-507.
-
(2008)
Cell
, vol.134
, pp. 496-507
-
-
Hansen, G.1
Hercus, T.R.2
McClure, B.J.3
-
40
-
-
0026065403
-
Identification of functionally distinct domains of human granulocyte-macrophage colony-stimulating factor using monoclonal antibodies
-
Kanakura Y, Cannistra SA, Brown CB, et al. Identification of functionally distinct domains of human granulocyte-macrophage colony-stimulating factor using monoclonal antibodies. Blood. 1991;77:1033-1043.
-
(1991)
Blood
, vol.77
, pp. 1033-1043
-
-
Kanakura, Y.1
Cannistra, S.A.2
Brown, C.B.3
-
41
-
-
0025610054
-
Monoclonal antibodies that recognize human granulocyte-macrophage colony-stimulating factor and neutralize its bioactivity in vitro
-
Dempsey PJ, Layton JE, Duhrsen U, et al. Monoclonal antibodies that recognize human granulocyte-macrophage colony-stimulating factor and neutralize its bioactivity in vitro. Hybridoma. 1990;9:545-558.
-
(1990)
Hybridoma
, vol.9
, pp. 545-558
-
-
Dempsey, P.J.1
Layton, J.E.2
Duhrsen, U.3
-
42
-
-
0033568467
-
Simultaneous antagonism of interleukin-5, granulocyte-macrophage colony-stimulating factor, and interleukin-3 stimulation of human eosinophils by targetting the common cytokine binding site of their receptors
-
Sun Q, Jones K, McClure B, et al. Simultaneous antagonism of interleukin-5, granulocyte-macrophage colony-stimulating factor, and interleukin-3 stimulation of human eosinophils by targetting the common cytokine binding site of their receptors. Blood. 1999;94:1943-1951.
-
(1999)
Blood
, vol.94
, pp. 1943-1951
-
-
Sun, Q.1
Jones, K.2
McClure, B.3
-
43
-
-
0028233122
-
Identification of residues in the first and fourth helices of human granulocyte-macrophage colony stimulating factor involved in binding to the α- and β-chains of the receptor
-
Hercus TR, Cambareri B, Dottore M, et al. Identification of residues in the first and fourth helices of human granulocyte-macrophage colony stimulating factor involved in binding to the α- and β-chains of the receptor. Blood. 1994;83:3500-3508.
-
(1994)
Blood
, vol.83
, pp. 3500-3508
-
-
Hercus, T.R.1
Cambareri, B.2
Dottore, M.3
-
45
-
-
0029860206
-
A single tyrosine residue in the membrane-proximal domain of the GM-CSF, IL-3 and IL-5 receptor common β chain is necessary and sufficient for high affinity binding and signalling by all three ligands
-
Woodcock JM, Bagley CJ, Zacharakis B, Lopez AF. A single tyrosine residue in the membrane-proximal domain of the GM-CSF, IL-3 and IL-5 receptor common β chain is necessary and sufficient for high affinity binding and signalling by all three ligands. J Biol Chem. 1996;271:25999-26006.
-
(1996)
J Biol Chem
, vol.271
, pp. 25999-26006
-
-
Woodcock, J.M.1
Bagley, C.J.2
Zacharakis, B.3
Lopez, A.F.4
-
46
-
-
0030960120
-
Crucial role of the residue R280 at the F′-G′ loop of the human granulocyte/macrophage colony-stimulating factor receptor α chain for ligand recognition
-
Rajotte D, Cadieux C, Haman A, et al. Crucial role of the residue R280 at the F′-G′ loop of the human granulocyte/macrophage colony-stimulating factor receptor α chain for ligand recognition. J Exp Med. 1997;185:1939-1950.
-
(1997)
J Exp Med
, vol.185
, pp. 1939-1950
-
-
Rajotte, D.1
Cadieux, C.2
Haman, A.3
-
47
-
-
0033607540
-
Molecular determinants of the granulocyte-macrophage colony-stimulating factor receptor complex assembly
-
Haman A, Cadieux C, Wilkes B, et al. Molecular determinants of the granulocyte-macrophage colony-stimulating factor receptor complex assembly. J Biol Chem. 1999;274:34155-34163.
-
(1999)
J Biol Chem
, vol.274
, pp. 34155-34163
-
-
Haman, A.1
Cadieux, C.2
Wilkes, B.3
-
48
-
-
0025766757
-
Identification of critical amino acid residues in human and mouse granulocyte-macrophage colony-stimulating factor and their involvement in species specificity
-
Shanafelt AB, Johnson KE, Kastelein RA. Identification of critical amino acid residues in human and mouse granulocyte-macrophage colony-stimulating factor and their involvement in species specificity. J Biol Chem. 1991;266:13804-13810.
-
(1991)
J Biol Chem
, vol.266
, pp. 13804-13810
-
-
Shanafelt, A.B.1
Johnson, K.E.2
Kastelein, R.A.3
-
49
-
-
0028013295
-
Histidine-367 of the human common β chain of the receptor is critical for high-affinity binding of human granulocyte-macrophage colony-stimulating factor
-
Lock P, Metcalf D, Nicola NA. Histidine-367 of the human common β chain of the receptor is critical for high-affinity binding of human granulocyte-macrophage colony-stimulating factor. Proc Natl Acad Sci U S A. 1994;91:252-256.
-
(1994)
Proc Natl Acad Sci U S A
, vol.91
, pp. 252-256
-
-
Lock, P.1
Metcalf, D.2
Nicola, N.A.3
-
50
-
-
0029805606
-
Refined crystal structure and mutagenesis of human granulocyte-macrophage colony-stimulating factor
-
Rozwarski DA, Diederichs K, Hecht R, Boone T, Karplus PA. Refined crystal structure and mutagenesis of human granulocyte-macrophage colony-stimulating factor. Proteins. 1996;26:304-313.
-
(1996)
Proteins
, vol.26
, pp. 304-313
-
-
Rozwarski, D.A.1
Diederichs, K.2
Hecht, R.3
Boone, T.4
Karplus, P.A.5
-
51
-
-
0034655647
-
Structure of the activation domain of the GMC-SF/IL-3/IL-5 receptor common β chain bound to an antagonist
-
Rossjohn J, McKinstry WJ, Woodcock JM, et al. Structure of the activation domain of the GMC-SF/IL-3/IL-5 receptor common β chain bound to an antagonist. Blood. 2000;95:2491-2498.
-
(2000)
Blood
, vol.95
, pp. 2491-2498
-
-
Rossjohn, J.1
McKinstry, W.J.2
Woodcock, J.M.3
-
52
-
-
0034615779
-
The solution structure of the cytokine-binding domain of the common β-chain of the receptors for granulocyte-macrophage colony-stimulating factor, interleukin-3 and interleukin-5
-
Mulhern TD, Lopez AF, D'Andrea RJ, et al. The solution structure of the cytokine-binding domain of the common β-chain of the receptors for granulocyte-macrophage colony-stimulating factor, interleukin-3 and interleukin-5. J Mol Biol. 2000;297:989-1001.
-
(2000)
J Mol Biol
, vol.297
, pp. 989-1001
-
-
Mulhern, T.D.1
Lopez, A.F.2
D'Andrea, R.J.3
-
53
-
-
17744386517
-
Structure of the complete extracellular domain of the common β subunit of the human GM-CSF, IL-3, and IL-5 receptors reveals a novel dimer configuration
-
Carr PD, Gustin SE, Church AP, et al. Structure of the complete extracellular domain of the common β subunit of the human GM-CSF, IL-3, and IL-5 receptors reveals a novel dimer configuration. Cell. 2001;104:291-300.
-
(2001)
Cell
, vol.104
, pp. 291-300
-
-
Carr, P.D.1
Gustin, S.E.2
Church, A.P.3
-
54
-
-
0344089342
-
Molecular assembly of the ternary granulocyte-macrophage colony-stimulating factor receptor complex
-
McClure BJ, Hercus TR, Cambareri BA, et al. Molecular assembly of the ternary granulocyte-macrophage colony-stimulating factor receptor complex. Blood. 2003;101:1308-1315.
-
(2003)
Blood
, vol.101
, pp. 1308-1315
-
-
McClure, B.J.1
Hercus, T.R.2
Cambareri, B.A.3
-
55
-
-
49249101222
-
Crystallization and preliminary X-ray diffraction analysis of the ternary human GM-CSF receptor complex
-
Hansen G, Hercus TR, Xu Y, et al. Crystallization and preliminary X-ray diffraction analysis of the ternary human GM-CSF receptor complex. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2008;64:711-714.
-
(2008)
Acta Crystallogr Sect F Struct Biol Cryst Commun
, vol.64
, pp. 711-714
-
-
Hansen, G.1
Hercus, T.R.2
Xu, Y.3
-
56
-
-
33745152640
-
An improved resolution structure of the human β common receptor involved in IL-3, IL-5 and GM-CSF signalling which gives better definition of the high-affinity binding epitope
-
Carr PD, Conlan F, Ford S, Ollis DL, Young IG. An improved resolution structure of the human β common receptor involved in IL-3, IL-5 and GM-CSF signalling which gives better definition of the high-affinity binding epitope. Acta Crystallographr Sect F Struct Biol Cryst Commun. 2006;62:509-513.
-
(2006)
Acta Crystallographr Sect F Struct Biol Cryst Commun
, vol.62
, pp. 509-513
-
-
Carr, P.D.1
Conlan, F.2
Ford, S.3
Ollis, D.L.4
Young, I.G.5
-
57
-
-
0026598960
-
Human growth hormone and extracellular domain of its receptor: Crystal structure of the complex
-
de Vos AM, Ultsch M, Kossiakoff AA. Human growth hormone and extracellular domain of its receptor: crystal structure of the complex. Science. 1992;255:306-312.
-
(1992)
Science
, vol.255
, pp. 306-312
-
-
De Vos, A.M.1
Ultsch, M.2
Kossiakoff, A.A.3
-
58
-
-
0029982521
-
Hematopoietic receptor complexes
-
Wells JA, De Vos AM. Hematopoietic receptor complexes. Annu Rev Biochem. 1996;65:609-634.
-
(1996)
Annu Rev Biochem
, vol.65
, pp. 609-634
-
-
Wells, J.A.1
De Vos, A.M.2
-
59
-
-
0026511904
-
Residue 21 of human granulocyte-macrophage colony-stimulating factor is critical for biological activity and for high but not low affinity binding
-
Lopez AF, Shannon MF, Hercus T, et al. Residue 21 of human granulocyte-macrophage colony-stimulating factor is critical for biological activity and for high but not low affinity binding. EMBO J. 1992;11:909-916.
-
(1992)
EMBO J
, vol.11
, pp. 909-916
-
-
Lopez, A.F.1
Shannon, M.F.2
Hercus, T.3
-
60
-
-
0028226252
-
Specific human granulocyte-macrophage colony-stimulating factor antagonists
-
Hercus TR, Bagley CJ, Cambareri B, et al. Specific human granulocyte-macrophage colony-stimulating factor antagonists. Proc Natl Acad Sci U S A. 1994;91:5838-5842.
-
(1994)
Proc Natl Acad Sci U S A
, vol.91
, pp. 5838-5842
-
-
Hercus, T.R.1
Bagley, C.J.2
Cambareri, B.3
-
61
-
-
0038532303
-
A novel functional epitope formed by domains 1 and 4 of the human common β-subunit is involved in receptor activation by granulocyte macrophage colony-stimulating factor and interleukin 5
-
Murphy JM, Ford SC, Wiedemann UM, et al. A novel functional epitope formed by domains 1 and 4 of the human common β-subunit is involved in receptor activation by granulocyte macrophage colony-stimulating factor and interleukin 5. J Biol Chem. 2003;278:10572-10577.
-
(2003)
J Biol Chem
, vol.278
, pp. 10572-10577
-
-
Murphy, J.M.1
Ford, S.C.2
Wiedemann, U.M.3
-
62
-
-
0028245262
-
Two contiguous residues in human interleukin-3, Asp21 and Glu22, selectively interact with the α- and β-chains of its receptor and participate in function
-
Barry SC, Bagley CJ, Phillips J, et al. Two contiguous residues in human interleukin-3, Asp21 and Glu22, selectively interact with the α- and β-chains of its receptor and participate in function. J Biol Chem. 1994;269:8488-8492.
-
(1994)
J Biol Chem
, vol.269
, pp. 8488-8492
-
-
Barry, S.C.1
Bagley, C.J.2
Phillips, J.3
-
63
-
-
0029000927
-
Identification of receptor-binding domains on human interleukin 5 and design of an interleukin 5-derived receptor antagonist
-
Tavernier J, Tuypens T, Verhee A, et al. Identification of receptor-binding domains on human interleukin 5 and design of an interleukin 5-derived receptor antagonist. Proc Natl Acad Sci U S A. 1995;92:5194-5198.
-
(1995)
Proc Natl Acad Sci U S A
, vol.92
, pp. 5194-5198
-
-
Tavernier, J.1
Tuypens, T.2
Verhee, A.3
-
64
-
-
0030744972
-
The human granulocyte-macrophage colony-stimulating factor (GM-CSF) receptor exists as a preformed receptor complex that can be activated by GM-CSF interleukin-3, or interleukin-5
-
Woodcock JM, McClure B, Stomski FC, et al. The human granulocyte- macrophage colony-stimulating factor (GM-CSF) receptor exists as a preformed receptor complex that can be activated by GM-CSF interleukin-3, or interleukin-5. Blood. 1997;90:3005-3017.
-
(1997)
Blood
, vol.90
, pp. 3005-3017
-
-
Woodcock, J.M.1
McClure, B.2
Stomski, F.C.3
-
66
-
-
0141527338
-
Convergent mechanisms for recognition of divergent cytokines by the shared signaling receptor gp130
-
Boulanger MJ, Bankovich AJ, Kortemme T, Baker D, Garcia KC. Convergent mechanisms for recognition of divergent cytokines by the shared signaling receptor gp130. Mol Cell. 2003;12:577-589.
-
(2003)
Mol Cell
, vol.12
, pp. 577-589
-
-
Boulanger, M.J.1
Bankovich, A.J.2
Kortemme, T.3
Baker, D.4
Garcia, K.C.5
-
67
-
-
27944505913
-
Structure of the quaternary complex of interleukin-2 with its α, β, and γc receptors
-
Wang X, Rickert M, Garcia KC. Structure of the quaternary complex of interleukin-2 with its α, β, and γc receptors. Science. 2005;310:1159-1163.
-
(2005)
Science
, vol.310
, pp. 1159-1163
-
-
Wang, X.1
Rickert, M.2
Garcia, K.C.3
-
68
-
-
33644540157
-
Crystal structure of the IL-2 signaling complex: Paradigm for a heterotrimeric cytokine receptor
-
Stauber DJ, Debler EW, Horton PA, Smith KA, Wilson IA. Crystal structure of the IL-2 signaling complex: paradigm for a heterotrimeric cytokine receptor. Proc Natl Acad Sci U S A. 2006;103:2788-2793.
-
(2006)
Proc Natl Acad Sci U S A
, vol.103
, pp. 2788-2793
-
-
Stauber, D.J.1
Debler, E.W.2
Horton, P.A.3
Smith, K.A.4
Wilson, I.A.5
-
69
-
-
38649137731
-
Molecular and structural basis of cytokine receptor pleiotropy in the interleukin-4/13 system
-
LaPorte SL, Juo ZS, Vaclavikova J, et al. Molecular and structural basis of cytokine receptor pleiotropy in the interleukin-4/13 system. Cell. 2008;132:259-272.
-
(2008)
Cell
, vol.132
, pp. 259-272
-
-
LaPorte, S.L.1
Juo, Z.S.2
Vaclavikova, J.3
-
70
-
-
0033574713
-
Crystal structure of the interleukin-4/receptor α chain complex reveals a mosaic binding interface
-
Hage T, Sebald W, Reinemer P. Crystal structure of the interleukin-4/receptor α chain complex reveals a mosaic binding interface. Cell. 1999;97:271-281.
-
(1999)
Cell
, vol.97
, pp. 271-281
-
-
Hage, T.1
Sebald, W.2
Reinemer, P.3
-
71
-
-
22444442637
-
Signaling conformations of the tall cytokine receptor gp130 when in complex with IL-6 and IL-6 receptor
-
Skiniotis G, Boulanger MJ, Garcia KC, Walz T. Signaling conformations of the tall cytokine receptor gp130 when in complex with IL-6 and IL-6 receptor. Nat Struct Mol Biol. 2005;12:545-551.
-
(2005)
Nat Struct Mol Biol
, vol.12
, pp. 545-551
-
-
Skiniotis, G.1
Boulanger, M.J.2
Garcia, K.C.3
Walz, T.4
-
72
-
-
0034644539
-
Cell signaling by receptor tyrosine kinases
-
Schlessinger J. Cell signaling by receptor tyrosine kinases. Cell. 2000;103:211-225.
-
(2000)
Cell
, vol.103
, pp. 211-225
-
-
Schlessinger, J.1
-
73
-
-
0026733625
-
Critical cytoplasmic domains of the common β subunit of the human GM-CSF, IL-3 and IL-5 receptors for growth signal transduction and tyrosine phosphorylation
-
Sakamaki K, Miyajima I, Kitamura T, Miyajima A. Critical cytoplasmic domains of the common β subunit of the human GM-CSF, IL-3 and IL-5 receptors for growth signal transduction and tyrosine phosphorylation. EMBO J. 1992;11:3541-3549.
-
(1992)
EMBO J
, vol.11
, pp. 3541-3549
-
-
Sakamaki, K.1
Miyajima, I.2
Kitamura, T.3
Miyajima, A.4
-
74
-
-
0029598480
-
Roles of the cytoplasmic domains of the α and β subunits of human granulocyte-macrophage colony-stimulating factor receptor
-
Muto A, Watanabe S, Itoh T, et al. Roles of the cytoplasmic domains of the α and β subunits of human granulocyte-macrophage colony-stimulating factor receptor. J Allergy Clin Immunol. 1995;96:1100-1114.
-
(1995)
J Allergy Clin Immunol
, vol.96
, pp. 1100-1114
-
-
Muto, A.1
Watanabe, S.2
Itoh, T.3
-
75
-
-
0027960979
-
Convergence of signaling by interleukin-3, granulocyte-macrophage colony-stimulating factor, and mast cell growth factor on JAK2 tyrosine kinase
-
Brizzi MF, Zini MG, Aronica MG, et al. Convergence of signaling by interleukin-3, granulocyte-macrophage colony-stimulating factor, and mast cell growth factor on JAK2 tyrosine kinase. J Biol Chem. 1994;269:31680-31684.
-
(1994)
J Biol Chem
, vol.269
, pp. 31680-31684
-
-
Brizzi, M.F.1
Zini, M.G.2
Aronica, M.G.3
-
76
-
-
0028180569
-
c chain of the receptor for granulocyte-macrophage colony-stimulating factor, and its activation requires the membrane proximal region
-
c chain of the receptor for granulocyte-macrophage colony-stimulating factor, and its activation requires the membrane proximal region. Mol Cell Biol. 1994;14:4335-4341.
-
(1994)
Mol Cell Biol
, vol.14
, pp. 4335-4341
-
-
Quelle, F.W.1
Sato, N.2
Witthuhn, B.A.3
-
77
-
-
0035869410
-
Distinct domains of the human granulocyte-macrophage colony-stimulating factor receptor α subunit mediate activation of Jak/Stat signaling and differentiation
-
Lilly MB, Zemskova M, Frankel AE, Salo J, Kraft AS. Distinct domains of the human granulocyte-macrophage colony-stimulating factor receptor α subunit mediate activation of Jak/Stat signaling and differentiation. Blood. 2001;97:1662-1670.
-
(2001)
Blood
, vol.97
, pp. 1662-1670
-
-
Lilly, M.B.1
Zemskova, M.2
Frankel, A.E.3
Salo, J.4
Kraft, A.S.5
-
78
-
-
0029903629
-
A dominant negative granulocyte-macrophage colony-stimuating factor receptor α chain reveals the multimeric structure of the receptor complex
-
Lia F, Rajotte D, Clark SC, Hoang T. A dominant negative granulocyte-macrophage colony-stimuating factor receptor α chain reveals the multimeric structure of the receptor complex. J Biol Chem. 1996;271:28287-28293.
-
(1996)
J Biol Chem
, vol.271
, pp. 28287-28293
-
-
Lia, F.1
Rajotte, D.2
Clark, S.C.3
Hoang, T.4
-
79
-
-
65549106958
-
A new isoform of interleukin-3 receptor α with novel differentiation activity and high affinity binding mode
-
Chen J, Olsen J, Ford S, et al. A new isoform of interleukin-3 receptor α with novel differentiation activity and high affinity binding mode. J Biol Chem. 2009;284:5763-5773.
-
(2009)
J Biol Chem
, vol.284
, pp. 5763-5773
-
-
Chen, J.1
Olsen, J.2
Ford, S.3
-
80
-
-
0031667742
-
Mechanism of activation of the GM-CSF, IL-3 and IL-5 family of receptors
-
Guthridge MA, Stomski FC, Thomas D, et al. Mechanism of activation of the GM-CSF, IL-3 and IL-5 family of receptors. Stem Cells. 1998;16:301-313.
-
(1998)
Stem Cells
, vol.16
, pp. 301-313
-
-
Guthridge, M.A.1
Stomski, F.C.2
Thomas, D.3
-
81
-
-
0028872649
-
Specificity of receptor tyrosine kinase signaling: Transient versus sustained extracellular signal-regulated kinase activation
-
Marshall CJ. Specificity of receptor tyrosine kinase signaling: transient versus sustained extracellular signal-regulated kinase activation. Cell. 1995;80:179-185.
-
(1995)
Cell
, vol.80
, pp. 179-185
-
-
Marshall, C.J.1
-
82
-
-
0033635183
-
Site-specific serine phosphorylation of the IL-3 receptor is required for hemopoietic cell survival
-
Guthridge MA, Stomski FC, Barry EF, et al. Site-specific serine phosphorylation of the IL-3 receptor is required for hemopoietic cell survival. Mol Cell. 2000;6:99-108.
-
(2000)
Mol Cell
, vol.6
, pp. 99-108
-
-
Guthridge, M.A.1
Stomski, F.C.2
Barry, E.F.3
-
83
-
-
1642541230
-
The phosphoserine-585-dependent pathway of the GM-CSF/IL-3/IL-5 receptors mediates hematopoietic cell survival through activation of NF-κB and induction of bcl-2
-
Guthridge MA, Barry EF, Felquer FA, et al. The phosphoserine-585- dependent pathway of the GM-CSF/IL-3/IL-5 receptors mediates hematopoietic cell survival through activation of NF-κB and induction of bcl-2. Blood. 2004;103:820-827.
-
(2004)
Blood
, vol.103
, pp. 820-827
-
-
Guthridge, M.A.1
Barry, E.F.2
Felquer, F.A.3
-
84
-
-
0022539985
-
Purified colony-stimulating factors enhance the survival of human neutrophils and eosinophils in vitro: A rapid and sensitive microassay for colony-stimulating factors
-
Begley CG, Lopez AF, Nicola NA, et al. Purified colony-stimulating factors enhance the survival of human neutrophils and eosinophils in vitro: a rapid and sensitive microassay for colony-stimulating factors. Blood. 1986;68:162-166.
-
(1986)
Blood
, vol.68
, pp. 162-166
-
-
Begley, C.G.1
Lopez, A.F.2
Nicola, N.A.3
-
85
-
-
0025091773
-
Haemopoietic colony stimulating factors promote cell survival by suppressing apoptosis
-
Williams GT, Smith CA, Spooncer E, Dexter TM, Taylor DR. Haemopoietic colony stimulating factors promote cell survival by suppressing apoptosis. Nature. 1990;343:76-79.
-
(1990)
Nature
, vol.343
, pp. 76-79
-
-
Williams, G.T.1
Smith, C.A.2
Spooncer, E.3
Dexter, T.M.4
Taylor, D.R.5
-
86
-
-
0041856377
-
Threonine 391 phosphorylation of the human prolactin receptor mediates a novel interaction with 14-3-3 proteins
-
Olayioye MA, Guthridge MA, Stomski FC, et al. Threonine 391 phosphorylation of the human prolactin receptor mediates a novel interaction with 14-3-3 proteins. J Biol Chem. 2003;278:32929-32935.
-
(2003)
J Biol Chem
, vol.278
, pp. 32929-32935
-
-
Olayioye, M.A.1
Guthridge, M.A.2
Stomski, F.C.3
-
87
-
-
34247107080
-
Phosphotyrosine/phosphoserine binary switches: A new paradigm for the regulation of PI3K signalling and growth factor pleiotropy?
-
Guthridge MA, Lopez AF. Phosphotyrosine/phosphoserine binary switches: a new paradigm for the regulation of PI3K signalling and growth factor pleiotropy? Biochem Soc Trans. 2007;35:250-252.
-
(2007)
Biochem Soc Trans
, vol.35
, pp. 250-252
-
-
Guthridge, M.A.1
Lopez, A.F.2
-
88
-
-
43249088084
-
Fibroblast growth factor receptor 2 phosphorylation on serine 779 couples to 14-3-3 and regulates cell survival and proliferation
-
Lonic A, Barry EF, Quach C, et al. Fibroblast growth factor receptor 2 phosphorylation on serine 779 couples to 14-3-3 and regulates cell survival and proliferation. Mol Cell Biol. 2008;28:3372-3385.
-
(2008)
Mol Cell Biol
, vol.28
, pp. 3372-3385
-
-
Lonic, A.1
Barry, E.F.2
Quach, C.3
-
89
-
-
36348943571
-
The Shc binding site of the βc subunit of the GM-CSF/IL-3/IL-5 receptors is a negative regulator of hematopoiesis
-
Ramshaw HS, Guthridge MA, Stomski FC, et al. The Shc binding site of the βc subunit of the GM-CSF/IL-3/IL-5 receptors is a negative regulator of hematopoiesis. Blood. 2007;110:3582-3590.
-
(2007)
Blood
, vol.110
, pp. 3582-3590
-
-
Ramshaw, H.S.1
Guthridge, M.A.2
Stomski, F.C.3
-
90
-
-
66449092365
-
14-3-3: SHC scaffolds integrate phoshoserine and phosphotyrosine signaling to regulate PI 3-kinase activation and cell survival
-
Barry EF, Felquer FA, Powell JA, et al. 14-3-3: SHC scaffolds integrate phoshoserine and phosphotyrosine signaling to regulate PI 3-kinase activation and cell survival. J Biol Chem. 2009;284:12080-12090.
-
(2009)
J Biol Chem
, vol.284
, pp. 12080-12090
-
-
Barry, E.F.1
Felquer, F.A.2
Powell, J.A.3
-
91
-
-
0031876318
-
Mcl-1 is an immediate-early gene activated by the granulocyte-macrophage colony-stimulating factor (GM-CSF) signalling pathway and is one component of the GM-CSF viability response
-
Chao J-R, Wang T-F, Lee S-F, et al. mcl-1 is an immediate-early gene activated by the granulocyte-macrophage colony-stimulating factor (GM-CSF) signalling pathway and is one component of the GM-CSF viability response. Mol Biol Cell. 1998;18:4883-4898.
-
(1998)
Mol Biol Cell
, vol.18
, pp. 4883-4898
-
-
Chao, J.-R.1
Wang, T.-F.2
Lee, S.-F.3
-
92
-
-
33745967414
-
Cell death in the absence of Bax and Bak
-
Lindsten T, Thompson CB. Cell death in the absence of Bax and Bak. Cell Death Differ. 2006;13:1272-1276.
-
(2006)
Cell Death Differ
, vol.13
, pp. 1272-1276
-
-
Lindsten, T.1
Thompson, C.B.2
-
93
-
-
33747190755
-
Cell death provoked by loss of interleukin-3 signaling is independent of Bad, Bim, and PI3 kinase, but depends in part on Puma
-
Ekert PG, Jabbour AM, Manoharan A, et al. Cell death provoked by loss of interleukin-3 signaling is independent of Bad, Bim, and PI3 kinase, but depends in part on Puma. Blood. 2006;108:1461-1468.
-
(2006)
Blood
, vol.108
, pp. 1461-1468
-
-
Ekert, P.G.1
Jabbour, A.M.2
Manoharan, A.3
-
94
-
-
33745966804
-
BH3-only proteins: Orchestrating cell death
-
Fletcher JI, Huang DC. BH3-only proteins: orchestrating cell death. Cell Death Differ. 2006;13:1268-1271.
-
(2006)
Cell Death Differ
, vol.13
, pp. 1268-1271
-
-
Fletcher, J.I.1
Huang, D.C.2
-
95
-
-
0033607506
-
Proapoptotic Bcl-2 relative Bim required for certain apoptotic responses, leukocyte homeostasis, and to preclude autoimmunity
-
Bouillet P, Metcalf D, Huang DC, et al. Proapoptotic Bcl-2 relative Bim required for certain apoptotic responses, leukocyte homeostasis, and to preclude autoimmunity. Science. 1999;286:1735-1738.
-
(1999)
Science
, vol.286
, pp. 1735-1738
-
-
Bouillet, P.1
Metcalf, D.2
Huang, D.C.3
-
96
-
-
10744228800
-
Puma is an essential mediator of p53-dependent and -independent apoptotic pathways
-
Jeffers JR, Parganas E, Lee Y, et al. Puma is an essential mediator of p53-dependent and -independent apoptotic pathways. Cancer Cells. 2003;4:321-328.
-
(2003)
Cancer Cells
, vol.4
, pp. 321-328
-
-
Jeffers, J.R.1
Parganas, E.2
Lee, Y.3
-
97
-
-
36048986227
-
The BH3-only protein Puma plays an essential role in cytokine deprivation induced apoptosis of mast cells
-
Ekoff M, Kaufmann T, Engstrom M, et al. The BH3-only protein Puma plays an essential role in cytokine deprivation induced apoptosis of mast cells. Blood. 2007;110:3209-3217.
-
(2007)
Blood
, vol.110
, pp. 3209-3217
-
-
Ekoff, M.1
Kaufmann, T.2
Engstrom, M.3
-
98
-
-
0030584088
-
Serine phosphorylation of death agonist BAD in response to survival factor results in binding to 14-3-3 not bcl-xL
-
Zha J, Harada H, Yang E, Jockel J, Korsmeyer SJ. Serine phosphorylation of death agonist BAD in response to survival factor results in binding to 14-3-3 not bcl-xL. Cell. 1996;87:619-628.
-
(1996)
Cell
, vol.87
, pp. 619-628
-
-
Zha, J.1
Harada, H.2
Yang, E.3
Jockel, J.4
Korsmeyer, S.J.5
-
99
-
-
1842333237
-
Interleukin-3-induced phosphorylation of Bad through the protein kinase Akt
-
del Peso L, Gonzalez-Garcia M, Page C, Herrera R, Nunez G. Interleukin-3-induced phosphorylation of Bad through the protein kinase Akt. Science. 1997;278:687-689.
-
(1997)
Science
, vol.278
, pp. 687-689
-
-
Del Peso, L.1
Gonzalez-Garcia, M.2
Page, C.3
Herrera, R.4
Nunez, G.5
-
100
-
-
23044514254
-
Regulatory phosphorylation of Bim: Sorting out the ERK from the JNK
-
Ley R, Ewings KE, Hadfield K, Cook SJ. Regulatory phosphorylation of Bim: sorting out the ERK from the JNK. Cell Death Differ. 2005;12:1008-1014.
-
(2005)
Cell Death Differ
, vol.12
, pp. 1008-1014
-
-
Ley, R.1
Ewings, K.E.2
Hadfield, K.3
Cook, S.J.4
-
101
-
-
10744230034
-
FoxO3a transcriptional regulation of Bim controls apoptosis in paclitaxel-treated breast cancer cell lines
-
Sunters A, Fernandez de MS, Stahl M, et al. FoxO3a transcriptional regulation of Bim controls apoptosis in paclitaxel-treated breast cancer cell lines. J Biol Chem. 2003;278:49795-49805.
-
(2003)
J Biol Chem
, vol.278
, pp. 49795-49805
-
-
Sunters, A.1
De Fernandez, M.S.2
Stahl, M.3
-
102
-
-
33745841375
-
FOXO3a-dependent regulation of Puma in response to cytokine/growth factor withdrawal
-
You H, Pellegrini M, Tsuchihara K, et al. FOXO3a-dependent regulation of Puma in response to cytokine/growth factor withdrawal. J Exp Med. 2006;203:1657-1663.
-
(2006)
J Exp Med
, vol.203
, pp. 1657-1663
-
-
You, H.1
Pellegrini, M.2
Tsuchihara, K.3
-
103
-
-
33644855216
-
Glycogen synthase kinase-3 regulates mitochondrial outer membrane permeabilization and apoptosis by destabilization of MCL-1
-
Maurer U, Charvet C, Wagman AS, Dejardin E, Green DR. Glycogen synthase kinase-3 regulates mitochondrial outer membrane permeabilization and apoptosis by destabilization of MCL-1. Mol Cell. 2006;21:749-760.
-
(2006)
Mol Cell
, vol.21
, pp. 749-760
-
-
Maurer, U.1
Charvet, C.2
Wagman, A.S.3
Dejardin, E.4
Green, D.R.5
-
104
-
-
34250179471
-
Glycogen synthase kinase 3α and 3β mediate a glucose-sensitive antiapoptotic signaling pathway to stabilize Mcl-1
-
Zhao Y, Altman BJ, Coloff JL, et al. Glycogen synthase kinase 3α and 3β mediate a glucose-sensitive antiapoptotic signaling pathway to stabilize Mcl-1. Mol Cell Biol. 2007;27:4328-4339.
-
(2007)
Mol Cell Biol
, vol.27
, pp. 4328-4339
-
-
Zhao, Y.1
Altman, B.J.2
Coloff, J.L.3
-
105
-
-
0036529829
-
Transient hematologic and clinical effect of E21R in a child with end-stage juvenile myelomonocytic leukemia
-
Bernard F, Thomas C, Emile JF, et al. Transient hematologic and clinical effect of E21R in a child with end-stage juvenile myelomonocytic leukemia. Blood. 2002;99:2615-2616.
-
(2002)
Blood
, vol.99
, pp. 2615-2616
-
-
Bernard, F.1
Thomas, C.2
Emile, J.F.3
-
106
-
-
0032400865
-
Diphtheria toxin fused to granulocyte-macrophage colony-stimulating factor is toxic to blasts from patients with juvenile myelomonocytic leukemia and chronic myelomonocytic leukemia
-
Frankel AE, Lilly M, Kreitman R, et al. Diphtheria toxin fused to granulocyte-macrophage colony-stimulating factor is toxic to blasts from patients with juvenile myelomonocytic leukemia and chronic myelomonocytic leukemia. Blood. 1998;92:4279-4286.
-
(1998)
Blood
, vol.92
, pp. 4279-4286
-
-
Frankel, A.E.1
Lilly, M.2
Kreitman, R.3
-
107
-
-
0347123433
-
Tumor-educated macrophages promote tumor progression and metastasis
-
Pollard JW. Tumor-educated macrophages promote tumor progression and metastasis. Nat Rev Cancer. 2004;4:71-78.
-
(2004)
Nat Rev Cancer
, vol.4
, pp. 71-78
-
-
Pollard, J.W.1
-
108
-
-
31044433663
-
Macrophages: Obligate partners for tumor cell migration, invasion, and metastasis
-
Condeelis J, Pollard JW. Macrophages: obligate partners for tumor cell migration, invasion, and metastasis. Cell. 2006;124:263-266.
-
(2006)
Cell
, vol.124
, pp. 263-266
-
-
Condeelis, J.1
Pollard, J.W.2
-
109
-
-
33751551172
-
Dual role of macrophages in tumor growth and angiogenesis
-
Lamagna C, Aurrand-Lions M, Imhof BA. Dual role of macrophages in tumor growth and angiogenesis. J Leukocyte Biol. 2006;80:705-713.
-
(2006)
J Leukocyte Biol
, vol.80
, pp. 705-713
-
-
Lamagna, C.1
Aurrand-Lions, M.2
Imhof, B.A.3
-
110
-
-
0034851864
-
Blockade of collagen-induced arthritis post-onset by antibody to granulocyte-macrophage colony-stimulating factor (GM-CSF): Requirement for GM-CSF in the effector phase of disease
-
Cook AD, Braine EL, Campbell IK, Rich MJ, Hamilton JA. Blockade of collagen-induced arthritis post-onset by antibody to granulocyte-macrophage colony-stimulating factor (GM-CSF): requirement for GM-CSF in the effector phase of disease. Arthritis Res. 2001;3:293-298.
-
(2001)
Arthritis Res
, vol.3
, pp. 293-298
-
-
Cook, A.D.1
Braine, E.L.2
Campbell, I.K.3
Rich, M.J.4
Hamilton, J.A.5
-
111
-
-
0035476518
-
Granulocyte macrophage colony-stimulating factor: A new putative therapeutic target in multiple sclerosis
-
McQualter JL, Darwiche R, Ewing C, et al. Granulocyte macrophage colony-stimulating factor: a new putative therapeutic target in multiple sclerosis. J Exp Med. 2001;194:873-882.
-
(2001)
J Exp Med
, vol.194
, pp. 873-882
-
-
McQualter, J.L.1
Darwiche, R.2
Ewing, C.3
-
112
-
-
0037044696
-
Local delivery of granulocyte macrophage colony-stimulating factor by retrovirally transduced antigen-specific T cells leads to severe, chronic experimental autoimmune encephalomyelitis in mice
-
Marusic S, Miyashiro JS, Douhan J, III, et al. Local delivery of granulocyte macrophage colony-stimulating factor by retrovirally transduced antigen-specific T cells leads to severe, chronic experimental autoimmune encephalomyelitis in mice. Neurosci Lett. 2002;332:185-189.
-
(2002)
Neurosci Lett
, vol.332
, pp. 185-189
-
-
Marusic, S.1
Miyashiro, J.S.2
Douhan III, J.3
-
113
-
-
33846018916
-
GMCSF production by autoreactive T cells is required for the activation of microglial cells and the onset of experimental autoimmune encephalomyelitis
-
Ponomarev ED, Shriver LP, Maresz K, et al. GMCSF production by autoreactive T cells is required for the activation of microglial cells and the onset of experimental autoimmune encephalomyelitis. J Immunol. 2007;178:39-48.
-
(2007)
J Immunol
, vol.178
, pp. 39-48
-
-
Ponomarev, E.D.1
Shriver, L.P.2
Maresz, K.3
-
114
-
-
0036154058
-
The requirement for granulocyte-macrophage colony-stimulating factor and granulocyte colony-stimulating factor in leukocyte-mediated immune glomerular injury
-
Kitching AR, Ru Huang X, Turner AL, et al. The requirement for granulocyte-macrophage colony-stimulating factor and granulocyte colony-stimulating factor in leukocyte-mediated immune glomerular injury. J Am Soc Nephrol. 2002;13:350-358.
-
(2002)
J Am Soc Nephrol
, vol.13
, pp. 350-358
-
-
Kitching, A.R.1
Ru Huang, X.2
Turner, A.L.3
-
115
-
-
33644814617
-
Granulocyte macrophage colony-stimulating factor expression by both renal parenchymal and immune cells mediates murine crescentic glomerulonephritis
-
Timoshanko JR, Kitching AR, Semple TJ, Holdsworth SR, Tipping PG. Granulocyte macrophage colony-stimulating factor expression by both renal parenchymal and immune cells mediates murine crescentic glomerulonephritis. J Am Soc Nephrol. 2005;16:2646-2656.
-
(2005)
J Am Soc Nephrol
, vol.16
, pp. 2646-2656
-
-
Timoshanko, J.R.1
Kitching, A.R.2
Semple, T.J.3
Holdsworth, S.R.4
Tipping, P.G.5
-
116
-
-
0033815950
-
The interleukin-3 receptor α chain is a unique marker for human acute myelogenous leukemia stem cells
-
Jordan CT, Upchurch D, Szilvassy SJ, et al. The interleukin-3 receptor α chain is a unique marker for human acute myelogenous leukemia stem cells. Leukemia. 2000;14:1777-1784.
-
(2000)
Leukemia
, vol.14
, pp. 1777-1784
-
-
Jordan, C.T.1
Upchurch, D.2
Szilvassy, S.J.3
-
117
-
-
0035662980
-
Interleukin-3 receptor α chain (CD123) is widely expressed in hematologic malignancies
-
Muñoz L, Nomdedeu JF, Lopez O, et al. Interleukin-3 receptor α chain (CD123) is widely expressed in hematologic malignancies. Haematologica. 2001;86:1261-1269.
-
(2001)
Haematologica
, vol.86
, pp. 1261-1269
-
-
Muñoz, L.1
Nomdedeu, J.F.2
Lopez, O.3
-
118
-
-
0742286841
-
Expression and prognostic value of hemopoietic cytokine receptors in acute myeloid leukemia (AML): Implications for future therapeutical strategies
-
Graf M, Hecht K, Reif S, et al. Expression and prognostic value of hemopoietic cytokine receptors in acute myeloid leukemia (AML): implications for future therapeutical strategies. Eur J Haematol. 2004;72:89-106.
-
(2004)
Eur J Haematol
, vol.72
, pp. 89-106
-
-
Graf, M.1
Hecht, K.2
Reif, S.3
-
119
-
-
61949250521
-
CD123 (IL-3 receptor α chain) neutralization by a monoclonal antibody selectively eliminates human acute myeloid leukemic stem cells
-
Lock RB, Jin L, Lee EM, et al. CD123 (IL-3 receptor α chain) neutralization by a monoclonal antibody selectively eliminates human acute myeloid leukemic stem cells. Blood (ASH Annual Meeting Abstracts). 2007;110:161.
-
(2007)
Blood (ASH Annual Meeting Abstracts)
, vol.110
, pp. 161
-
-
Lock, R.B.1
Jin, L.2
Lee, E.M.3
-
121
-
-
40949146020
-
Treatment of patients with the hypereosinophilic syndrome with mepolizumab
-
Rothenberg ME, Klion AD, Roufosse FE, et al. Treatment of patients with the hypereosinophilic syndrome with mepolizumab. N Engl J Med. 2008;358:1215-1228.
-
(2008)
N Engl J Med
, vol.358
, pp. 1215-1228
-
-
Rothenberg, M.E.1
Klion, A.D.2
Roufosse, F.E.3
-
122
-
-
61849155730
-
Mepolizumab for prednisone-dependent asthma with sputum eosinophilia
-
Nair P, Pizzichini MM, Kjarsgaard M, et al. Mepolizumab for prednisone-dependent asthma with sputum eosinophilia. N Engl J Med. 2009;360:985-993.
-
(2009)
N Engl J Med
, vol.360
, pp. 985-993
-
-
Nair, P.1
Pizzichini, M.M.2
Kjarsgaard, M.3
-
123
-
-
61849086181
-
Mepolizumab and exacerbations of refractory eosinophilic asthma
-
Haldar P, Brightling CE, Hargadon B, et al. Mepolizumab and exacerbations of refractory eosinophilic asthma. N Engl J Med. 2009;360:973-984.
-
(2009)
N Engl J Med
, vol.360
, pp. 973-984
-
-
Haldar, P.1
Brightling, C.E.2
Hargadon, B.3
-
124
-
-
0036826485
-
Attenuation of airway hyperresponsiveness in a murine asthma model by neutralization of granulocyte-macrophage colony-stimulating factor (GM-CSF)
-
Yamashita N, Tashimo H, Ishida H, et al. Attenuation of airway hyperresponsiveness in a murine asthma model by neutralization of granulocyte-macrophage colony-stimulating factor (GM-CSF). Cell Immunol. 2002;219:92-97.
-
(2002)
Cell Immunol
, vol.219
, pp. 92-97
-
-
Yamashita, N.1
Tashimo, H.2
Ishida, H.3
-
125
-
-
0037044792
-
Granulocyte/Macrophage-colony-stimulating factor (GM-CSF) regulates lung innate immunity to lipopolysaccharide through Akt/Erk activation of NFκB and AP-1 in vivo
-
Bozinovski S, Jones JE, Vlahos R, Hamilton JA, Anderson GP. Granulocyte/Macrophage-colony-stimulating factor (GM-CSF) regulates lung innate immunity to lipopolysaccharide through Akt/Erk activation of NFκB and AP-1 in vivo. J Biol Chem. 2002;277:42808-42814.
-
(2002)
J Biol Chem
, vol.277
, pp. 42808-42814
-
-
Bozinovski, S.1
Jones, J.E.2
Vlahos, R.3
Hamilton, J.A.4
Anderson, G.P.5
-
126
-
-
33748053351
-
Therapeutic potential of treating chronic obstructive pulmonary disease (COPD) by neutralizing granulocyte macrophage-colony stimulating factor (GM-CSF)
-
Vlahos R, Bozinovski S, Hamilton JA, Anderson GP. Therapeutic potential of treating chronic obstructive pulmonary disease (COPD) by neutralizing granulocyte macrophage-colony stimulating factor (GM-CSF). Pharmacol Ther. 2006;112:106-115.
-
(2006)
Pharmacol Ther
, vol.112
, pp. 106-115
-
-
Vlahos, R.1
Bozinovski, S.2
Hamilton, J.A.3
Anderson, G.P.4
-
127
-
-
40449117731
-
The IL-3/IL-5/GM-CSF common receptor plays a pivotal role in the regulation of Th2 immunity and allergic airway inflammation
-
Asquith KL, Ramshaw HS, Hansbro PM, et al. The IL-3/IL-5/GM-CSF common receptor plays a pivotal role in the regulation of Th2 immunity and allergic airway inflammation. J Immunol. 2008;180:1199-1206.
-
(2008)
J Immunol
, vol.180
, pp. 1199-1206
-
-
Asquith, K.L.1
Ramshaw, H.S.2
Hansbro, P.M.3
-
128
-
-
54349086521
-
Mutations of JAK2 in acute lymphoblastic leukemias associated with Down's syndrome
-
Bercovich D, Ganmore I, Scott LM, et al. Mutations of JAK2 in acute lymphoblastic leukemias associated with Down's syndrome. Lancet. 2008;372:1484-1492.
-
(2008)
Lancet
, vol.372
, pp. 1484-1492
-
-
Bercovich, D.1
Ganmore, I.2
Scott, L.M.3
-
129
-
-
43549109620
-
The Jak2V617F oncogene associated with myeloproliferative diseases requires a functional FERM domain for transformation and for expression of the Myc and Pim proto-oncogenes
-
Wernig G, Gonneville JR, Crowley BJ, et al. The Jak2V617F oncogene associated with myeloproliferative diseases requires a functional FERM domain for transformation and for expression of the Myc and Pim proto-oncogenes. Blood. 2008;111:3751-3759.
-
(2008)
Blood
, vol.111
, pp. 3751-3759
-
-
Wernig, G.1
Gonneville, J.R.2
Crowley, B.J.3
-
130
-
-
30044437118
-
Expression of a homodimeric type I cytokine receptor is required for JAK2V617F-mediated transformation
-
Lu X, Levine R, Tong W, et al. Expression of a homodimeric type I cytokine receptor is required for JAK2V617F-mediated transformation. Proc Natl Acad Sci U S A. 2005;102:18962-18967.
-
(2005)
Proc Natl Acad Sci U S A
, vol.102
, pp. 18962-18967
-
-
Lu, X.1
Levine, R.2
Tong, W.3
-
131
-
-
41949118675
-
Dimerization by a cytokine receptor is necessary for constitutive activation of JAK2V617F
-
Lu X, Huang LJ, Lodish HF. Dimerization by a cytokine receptor is necessary for constitutive activation of JAK2V617F. J Biol Chem. 2008;283:5258-5266.
-
(2008)
J Biol Chem
, vol.283
, pp. 5258-5266
-
-
Lu, X.1
Huang, L.J.2
Lodish, H.F.3
-
132
-
-
0026667283
-
Polycythemia vera. II. Hypersensitivity of bone marrow erythroid, granulocyte-macrophage, and megakaryocyte progenitor cells to interleukin-3 and granulocyte-macrophage colony-stimulating factor
-
Dai CH, Krantz SB, Dessypris EN, et al. Polycythemia vera. II. Hypersensitivity of bone marrow erythroid, granulocyte-macrophage, and megakaryocyte progenitor cells to interleukin-3 and granulocyte-macrophage colony-stimulating factor. Blood. 1992;80:891-899.
-
(1992)
Blood
, vol.80
, pp. 891-899
-
-
Dai, C.H.1
Krantz, S.B.2
Dessypris, E.N.3
-
133
-
-
0034651043
-
Inhibition of juvenile myelomonocytic leukemia cell growth in vitro by farnesyltransferase inhibitors
-
Emanuel PD, Snyder RC, Wiley T, Gopurala B, Castleberry RP. Inhibition of juvenile myelomonocytic leukemia cell growth in vitro by farnesyltransferase inhibitors. Blood. 2000;95:639-645.
-
(2000)
Blood
, vol.95
, pp. 639-645
-
-
Emanuel, P.D.1
Snyder, R.C.2
Wiley, T.3
Gopurala, B.4
Castleberry, R.P.5
-
134
-
-
0036090222
-
Primitive, quiescent, Philadelphia-positive stem cells from patients with chronic myeloid leukemia are insensitive to STI571 in vitro
-
Graham SM, Jorgensen HG, Allan E, et al. Primitive, quiescent, Philadelphia-positive stem cells from patients with chronic myeloid leukemia are insensitive to STI571 in vitro. Blood. 2002;99:319-325.
-
(2002)
Blood
, vol.99
, pp. 319-325
-
-
Graham, S.M.1
Jorgensen, H.G.2
Allan, E.3
-
135
-
-
43749122581
-
BCR-ABL oncogenic transformation of NIH 3T3 fibroblasts requires the IL-3 receptor
-
Tao WJ, Lin H, Sun T, Samanta AK, Arlinghaus R. BCR-ABL oncogenic transformation of NIH 3T3 fibroblasts requires the IL-3 receptor. Oncogene. 2008;27:3194-3200.
-
(2008)
Oncogene
, vol.27
, pp. 3194-3200
-
-
Tao, W.J.1
Lin, H.2
Sun, T.3
Samanta, A.K.4
Arlinghaus, R.5
-
136
-
-
38049187096
-
Mammalian target of rapamycin (mTOR) inhibition activates phosphatidylinositol 3-kinase/Akt by upregulating insulin-like growth factor-1 receptor signaling in acute myeloid leukemia: Rationale for therapeutic inhibition of both pathways
-
Tamburini J, Chapuis N, Bardet V, et al. Mammalian target of rapamycin (mTOR) inhibition activates phosphatidylinositol 3-kinase/Akt by upregulating insulin-like growth factor-1 receptor signaling in acute myeloid leukemia: rationale for therapeutic inhibition of both pathways. Blood. 2008;111:379-382.
-
(2008)
Blood
, vol.111
, pp. 379-382
-
-
Tamburini, J.1
Chapuis, N.2
Bardet, V.3
-
137
-
-
22544444889
-
Essential role for the p110 isoform in phosphoinositide 3-kinase activation and cell proliferation in acute myeloid leukemia
-
Sujobert P, Bardet V, Cornillet-Lefebvre P, et al. Essential role for the p110 isoform in phosphoinositide 3-kinase activation and cell proliferation in acute myeloid leukemia. Blood. 2005;106:1063-1066.
-
(2005)
Blood
, vol.106
, pp. 1063-1066
-
-
Sujobert, P.1
Bardet, V.2
Cornillet-Lefebvre, P.3
-
138
-
-
34547932268
-
Constitutive phosphoinositide 3-kinase/Akt activation represents a favorable prognostic factor in de novo acute myelogenous leukemia patients
-
Tamburini J, Elie C, Bardet V, et al. Constitutive phosphoinositide 3-kinase/Akt activation represents a favorable prognostic factor in de novo acute myelogenous leukemia patients. Blood. 2007;110:1025-1028.
-
(2007)
Blood
, vol.110
, pp. 1025-1028
-
-
Tamburini, J.1
Elie, C.2
Bardet, V.3
-
139
-
-
55349109688
-
Pathways to cancer therapy
-
Jones D. Pathways to cancer therapy. Nat Rev Drug Discov. 2008;7:875-876.
-
(2008)
Nat Rev Drug Discov
, vol.7
, pp. 875-876
-
-
Jones, D.1
-
140
-
-
0021821903
-
Involvement of the bcl-2 gene in human follicular lymphoma
-
Tsujimoto Y, Cossman J, Jaffe E, Croce CM. Involvement of the bcl-2 gene in human follicular lymphoma. Science. 1985;228:1440-1443.
-
(1985)
Science
, vol.228
, pp. 1440-1443
-
-
Tsujimoto, Y.1
Cossman, J.2
Jaffe, E.3
Croce, C.M.4
-
141
-
-
0346492579
-
Apaf-1 and caspase-9 do not act as tumor suppressors in myc-induced lymphomagenesis or mouse embryo fibroblast transformation
-
Scott CL, Schuler M, Marsden VS, et al. Apaf-1 and caspase-9 do not act as tumor suppressors in myc-induced lymphomagenesis or mouse embryo fibroblast transformation. J Cell Biol. 2004;164:89-96.
-
(2004)
J Cell Biol
, vol.164
, pp. 89-96
-
-
Scott, C.L.1
Schuler, M.2
Marsden, V.S.3
-
143
-
-
60849086456
-
Bcl-2 inhibitors: Small molecules with a big impact on cancer therapy
-
Vogler M, Dinsdale D, Dyer MJ, Cohen GM. Bcl-2 inhibitors: small molecules with a big impact on cancer therapy. Cell Death Differ. 2009;16:360-367.
-
(2009)
Cell Death Differ
, vol.16
, pp. 360-367
-
-
Vogler, M.1
Dinsdale, D.2
Dyer, M.J.3
Cohen, G.M.4
|