Interleukin-6 released by colon cancer-associated fibroblasts is critical for tumour angiogenesis: Anti-interleukin-6 receptor antibody suppressed angiogenesis and inhibited tumour-stroma interaction

British Journal of Cancer

Volumn 110, Issue 2, 2014, Pages 469-478

  Nagasaki, T ^a   Hara, M ^a   Nakanishi, H ^b   Takahashi, H ^a   Sato, M ^a   Takeyama, H ^a  

^a NAGOYA CITY UNIVERSITY   (Japan)

^b AICHI CANCER CENTER HOSPITAL   (Japan)

Author keywords

angiogenesis; cancer associated fibroblast (CAF); cancer stroma interaction (CSI); colon cancer; Interlerukin 6 (IL 6); VEGF

Indexed keywords

ANGIOGENESIS INHIBITOR; INTERLEUKIN 6; MR 16 1; RECEPTOR ANTIBODY; TOCILIZUMAB; UNCLASSIFIED DRUG; VASCULOTROPIN;

ANGIOGENESIS; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIANGIOGENIC ACTIVITY; ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER CELL CULTURE; CANCER GROWTH; CELL ISOLATION; COLON CANCER; CONTROLLED STUDY; CYTOKINE PRODUCTION; CYTOKINE RELEASE; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; FIBROBLAST; FIBROBLAST CULTURE; HUMAN; HUMAN CELL; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; REAL TIME POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; TUMOR XENOGRAFT;

ANIMALS; ANTIBODIES; CELL LINE; CELL LINE, TUMOR; COLONIC NEOPLASMS; FIBROBLASTS; HT29 CELLS; HUMANS; INFLAMMATION; INTERLEUKIN-6; MICE; MICE, NUDE; NEOVASCULARIZATION, PATHOLOGIC; RECEPTORS, INTERLEUKIN-6; STROMAL CELLS; VASCULAR ENDOTHELIAL GROWTH FACTOR A;

EID: 84892917277     PISSN: 00070920     EISSN: 15321827     Source Type: Journal    
DOI: 10.1038/bjc.2013.748     Document Type: Article

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