The anti-tumor activity of IL-12: Mechanisms of innate immunity that are model and dose dependent

Journal of Immunology

Volumn 165, Issue 5, 2000, Pages 2665-2670

  Smyth, M J ^a   Taniguchi, M ^a   Street, S E A ^a  

^a PETER MACCALLUM CANCER CENTRE   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

INTERLEUKIN 12; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 1; PERFORIN;

ANIMAL CELL; ANTINEOPLASTIC ACTIVITY; ARTICLE; CONTROLLED STUDY; GENE TARGETING; IMMUNE RESPONSE; METASTASIS; MOUSE; NATURAL KILLER CELL; NONHUMAN; PRIORITY JOURNAL; T LYMPHOCYTE; TUMOR IMMUNITY;

EID: 0034284460     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.165.5.2665     Document Type: Article

References (43)

1. Identification and purification of natural killer cell stimulatory factor (NKSF), a cytokine with multiple biologic effects on human lymphocytes
2. Cloning of cDNA for natural killer cell stimulatory factor, a heterodimeric cytokine with multiple biologic effects on T and natural killer cells
3. Regulation of human cytolytic lymphocyte responses by interleukin-12
4. Interleukin-12: A cytokine produced by antigen-presenting cells with immunoregulatory functions in the generation of T-helper cells type 1 and cytotoxic lymphocytes
5. Regulation of interleukin-12 expression in human monocytes: Selective priming by interferon-γ of lipopolysaccharide-inducible p35 and p40 genes
6. Interleukin-12: A proinflammatory cytokine with immunoregulatory functions
7. Natural killer cell stimulatory factor (interleukin 12 [IL-12]) induces T helper type 1 (Th1)-specific immune responses and inhibits the development of IL-4-producing Th cells
8. Interleukin-12 and its role in the generation of TH1 cells
9. Interleukin 12 primes macrophages for nitric oxide production in vivo and restores depressed nitric oxide production by macrophages from tumor-bearing mice: Implications for the antitumor activity of interleukin 12 and/or interleukin 2
10. Inhibition of angiogenesis in vivo by interleukin 12
11. Contribution of natural killer cells to inhibition of angiogenesis by interleukin-12
12. Antitumor and antimetastatic activity of interleukin 12 against murine tumors
13. Interleukin-12
14. Systemic administration of rIL-12 induces complete tumor regression and protective immunity: Response is correlated with a striking reversal of suppressed IFN-γ production by anti-tumor T cells
15. Interleukin 12: Basic biology and potential applications in cancer treatment
16. Recombinant IL-12 administration induces tumor regression in association with IFN- γ production
17. Cytokine and chemokine expression in tumors of mice receiving systemic therapy with IL-12
18. Administration of interleukin 12 with pulse interleukin 2 and the rapid and complete eradication of murine renal carcinoma
19. Fibroblasts genetically engineered to secrete interleukin 12 can suppress tumor growth and induce antitumor immunity to a murine melanoma in vivo
20. Administration of recombinant interleukin 12 prevents outgrowth of tumor cells metastasizing spontaneously to lung and lymph nodes
21. Human interferon-inducible protein 10 is a potent inhibitor of angiogenesis in vivo
22. Mig and IP-10: CXC chemokines that target lymphocytes
23. Release of reactive nitrogen intermediates and reactive oxygen intermediates from mouse peritoneal macrophages
24. Molecular mechanisms underlying IFN-γ-mediated tumor growth inhibition induced during tumor immunotherapy with rIL-12
25. IL-12 induces T helper 1-directed antitumor response
26. Requirement for Val4 NKT cells in IL-12-mediated rejection of tumors
27. + αβ T cells activated by IL-12 as a major effector in inhibition of experimental tumor metastasis
28. Perforin-dependent NK celt cytotoxicity is sufficient for anti-metastatic effect of IL-12
29. Differential tumor surveillance by NK and NKT cells
30. Multiple defects of immune cell function in mice with disrupted interferon-γ genes
31. Cytotoxicity mediated by T cells and natural killer cells is greatly impaired in perforin-deficient mice
32. IL-12 deficient mice are defective in IFN-γ production and type I cytokine responses
33. Perforin is a major contributor to NK cell control of tumor metastasis
34. 2-microglobulin-deficient mice
35. + αβ T cells with intermediate TCR induced in liver of mice by IL-12
36. m144, A murine cytomegalovirus (MCMV)-encoded major histocompatibility complex class I homologue, confers tumor resistance to natural killer cell-mediated rejection
37. Recruitment and activation of natural killer (NK) cells in vivo determined by the target cell phenotype: An adaptive component of NK cell-mediated responses
38. + T cells in IL-12-induced immune responses in vivo
39. Cutting edge: Cross-talk between cells of the innate immune system: NKT ceils rapidly activate NK cells
40. Interferon-γ and interleukin-4 regulate T cell interleukin-12 responsiveness through the differential modulation of high-affinity interleukin-12 receptor expression
41. NKT cells are phenotypically and functionally diverse
42. T cell-mediated, IFN-γ-facilitated rejection of murine B16 melanomas
43. Reconstitution of H-2 class I expression by gene transfection decreases susceptibility to natural killer cells of an EL4 class I loss variant