Stage-dependent alterations of the serum cytokine pattern in colorectal carcinoma

British Journal of Cancer

Volumn 107, Issue 10, 2012, Pages 1729-1736

  Kantola, T ^a   Klintrup, K ^b   Vayrynen J P ^a   Vornanen, J ^a   Bloigu, R ^c   Karhu, T ^a   Herzig, K H ^a,d   Napankangas J ^a   Makela J ^b   Karttunen, T J ^a,b   Tuomisto, A ^a   Makinen M J ^a,b  

^a UNIVERSITY OF OULU   (Finland)

^b OULU UNIVERSITY HOSPITAL   (Finland)

^c UNIVERSITY OF OULU   (Finland)

^d KUOPIO UNIVERSITY HOSPITAL   (Finland)

Author keywords

Biomarker; Chemokine; Colorectal cancer; Cytokine; Serum; Tumour immunology

Indexed keywords

C REACTIVE PROTEIN; CYTOKINE; GAMMA INTERFERON INDUCIBLE PROTEIN 10; INTERLEUKIN 1 RECEPTOR BLOCKING AGENT; INTERLEUKIN 6; INTERLEUKIN 7; INTERLEUKIN 8; MONOCYTE CHEMOTACTIC PROTEIN 1; PLATELET DERIVED GROWTH FACTOR;

ADULT; AREA UNDER THE CURVE; ARTICLE; CANCER PROGNOSIS; CANCER STAGING; CARCINOGENESIS; CLINICAL ASSESSMENT; COLORECTAL CARCINOMA; CONTROLLED STUDY; CORRELATION COEFFICIENT; CYTOKINE PRODUCTION; FEMALE; HISTOPATHOLOGY; HUMAN; LOGISTIC REGRESSION ANALYSIS; LYMPHOCYTE; MAJOR CLINICAL STUDY; MALE; METASTASIS; NEUTROPHIL; PREDICTIVE VALIDITY; PRIORITY JOURNAL; PROSPECTIVE STUDY; RECEIVER OPERATING CHARACTERISTIC; SYSTEMIC INFLAMMATORY RESPONSE SYNDROME; TH2 CELL; TUMOR IMMUNOLOGY; TUMOR MICROENVIRONMENT;

AGED; CHEMOKINE CCL2; COLORECTAL NEOPLASMS; FEMALE; HUMANS; INFLAMMATION; INTERLEUKINS; MALE; NEOPLASM STAGING; PLATELET-DERIVED GROWTH FACTOR; PROSPECTIVE STUDIES;

EID: 84869096388     PISSN: 00070920     EISSN: 15321827     Source Type: Journal    
DOI: 10.1038/bjc.2012.456     Document Type: Article

References (50)

1. Bailey C, Negus R, Morris A, Ziprin P, Goldin R, Allavena P, Peck D, Darzi A (2007) Chemokine expression is associated with the accumulation of tumour associated macrophages (TAMs) and progression in human colorectal cancer. Clin Exp Metastasis 24: 121-130. (Pubitemid 46669245)
2. Belizon A, Balik E, Horst PK, Shantha Kumara HM, Nasar A, Whelan RL (2009) Platelet-derived growth factor (subtype BB) is elevated in patients with colorectal carcinoma. Dis Colon Rectum 52: 1166-1171.
3. Brozek W, Bises G, Girsch T, Cross HS, Kaiser HE, Peterlik M (2005) Differentiation-dependent expression and mitogenic action of interleukin-6 in human colon carcinoma cells: relevance for tumour progression. Eur J Cancer 41: 2347-2354. (Pubitemid 41415612)
4. Burn J, Gerdes AM, Macrae F, Mecklin JP, Moeslein G, Olschwang S, Eccles D, Evans DG, Maher ER, Bertario L, Bisgaard ML, Dunlop MG, Ho JW, Hodgson SV, Lindblom A, Lubinski J, Morrison PJ, Murday V, Ramesar R, Side L, Scott RJ, Thomas HJ, Vasen HF, Barker G, Crawford G, Elliott F, Movahedi M, Pylvanainen K, Wijnen JT, Fodde R, Lynch HT, Mathers JC, Bishop DT, on behalf of the CAPP2 Investigators (2011) Long-term effect of aspirin on cancer risk in carriers of hereditary colorectal cancer: An analysis from the CAPP2 randomised controlled trial. Lancet 378: 2081-2087.
5. Capitini CM, Chisti AA, Mackall CL (2009) Modulating T-cell homeostasis with IL-7: preclinical and clinical studies. J Intern Med 266: 141-153.
6. Chung YC, Chang YF (2003) Serum interleukin-6 levels reflect the disease status of colorectal cancer. J Surg Oncol 83: 222-226.
7. Commins SP, Borish L, Steinke JW (2010) Immunologic messenger molecules: cytokines, interferons, and chemokines. J Allergy Clin Immunol 125: S53-S72.
8. Cui G, Florholmen J (2008) Polarization of cytokine profile from Th1 into Th2 along colorectal adenoma-carcinoma sequence: implications for the biotherapeutic target? Inflamm Allergy Drug Targets 7: 94-97.
9. De Vita F, Orditura M, Lieto E, Infusino S, Morgillo F, Martinelli E, Castellano P, Romano C, Ciardiello F, Catalano G, Pignatelli C, Galizia G (2004) Elevated perioperative serum vascular endothelial growth factor levels in patients with colon carcinoma. Cancer 100: 270-278. (Pubitemid 38063634)
10. Duffy MJ (2001) Carcinoembryonic antigen as a marker for colorectal cancer: is it clinically useful? Clin Chem 47: 624-630. (Pubitemid 32275803)
11. Eaden JA, Abrams KR, Mayberry JF (2001) The risk of colorectal cancer in ulcerative colitis: A meta-Analysis. Gut 48: 526-535. (Pubitemid 32234798)
12. Ellyard JI, Simson L, Parish CR (2007) Th2-mediated anti-tumour immunity: friend or foe? Tissue Antigens 70: 1-11. (Pubitemid 46890289)
13. Erreni M, Mantovani A, Allavena P (2011) Tumor-Associated macrophages (TAM) and inflammation in colorectal cancer. Cancer Microenviron 4: 141-154.
14. Galon J, Costes A, Sanchez-Cabo F, Kirilovsky A, Mlecnik B, Lagorce-Pages C, Tosolini M, Camus M, Berger A, Wind P, Zinzindohoue F, Bruneval P, Cugnenc PH, Trajanoski Z, Fridman WH, Pages F (2006) Type, density, and location of immune cells within human colorectal tumors predict clinical outcome. Science 313: 1960-1964. (Pubitemid 44498003)
15. Hamilton SR, Bosman FT, Boffetta P, Ilyas M, Morreau H, Nakamura S-I, Quirke P, Riboli E, Sobin LH (2010) Carcinoma of the colon and rectum. In World Health Organization classification of tumours of the digestive system. Pathology and genetics of tumours of the digestive system, Bosman FT, Carneiro F, Hruban RH, Theise NDSR (eds). pp 134-146. IARC Press: Lyon.\
16. Hellberg C, Ostman A, Heldin CH (2010) PDGF and vessel maturation. Recent Results Cancer Res 180: 103-114.
17. Jenkins MA, Hayashi S, O'Shea AM, Burgart LJ, Smyrk TC, Shimizu D, Waring PM, Ruszkiewicz AR, Pollett AF, Redston M, Barker MA, Baron JA, Casey GR, Dowty JG, Giles GG, Limburg P, Newcomb P, Young JP, Walsh MD, Thibodeau SN, Lindor NM, Lemarchand L, Gallinger S, Haile RW, Potter JD, Hopper JL, Jass JR, Colon Cancer Family Registry (2007) Pathology features in Bethesda guidelines predict colorectal cancer microsatellite instability: A population-based study. Gastroenterology 133: 48-56. (Pubitemid 47039240)
18. Kaminska J, Nowacki MP, Kowalska M, Rysinska A, Chwalinski M, Fuksiewicz M, Michalski W, Chechlinska M (2005) Clinical significance of serum cytokine measurements in untreated colorectal cancer patients: soluble tumor necrosis factor receptor type IYan independent prognostic factor. Tumour Biol 26: 186-194. (Pubitemid 41379744)
19. Kang JC, Chen JS, Lee CH, Chang JJ, Shieh YS (2010) Intratumoral macrophage counts correlate with tumor progression in colorectal cancer. J Surg Oncol 102: 242-248.
20. Klintrup K. Mäkinen JM, Kauppila S, Väre PO, Melkko J, Tuominen H, Tuppurainen K, Mäkelä J, Karttunen TJ, Mäkinen MJ (2005) Inflammation and prognosis in colorectal cancer. Eur J Cancer 41: 2645-2654. (Pubitemid 41607555)
21. Knupfer H, Preiss R (2010) Serum interleukin-6 levels in colorectal cancer patientsYa summary of published results. Int J Colorectal Dis 25: 135-140.
22. Lee G, Lee JM, Gardner BK, Walser TC, Krysan K, Pak PS, Mao J, Hazra S, Dubinett SM (2010) Blood-based biomarker profiles for detecting lung cancer. J Thorac Oncol 5(Suppl 3): S220-S221.
23. Luster AD, Leder P (1993) IP-10, a -C-X-C- chemokine, elicits a potent thymus-dependent antitumor response in vivo. J Exp Med 178: 1057-1065. (Pubitemid 23260444)
24. Mackall CL, Fry TJ, Gress RE (2011) Harnessing the biology of IL-7 for therapeutic application. Nat Rev Immunol 11: 330-342.
25. Mantovani A, Allavena P, Sica A, Balkwill F (2008) Cancer-related inflammation. Nature 454: 436-444.
26. Melchionda F, Fry TJ, Milliron MJ, McKirdy MA, Tagaya Y, Mackall CL (2005) Adjuvant IL-7 or IL-15 overcomes immunodominance and improves survival of the CD8 memory cell pool. J Clin Invest 115: 1177-1187. (Pubitemid 40629036)
27. Mengus C, Le Magnen C, Trella E, Yousef K, Bubendorf L, Provenzano M, Bachmann A, Heberer M, Spagnoli GC, Wyler S (2011) Elevated levels of circulating IL-7 and IL-15 in patients with early stage prostate cancer. J Transl Med 9: 162.
28. Naito Y, Saito K, Shiiba K, Ohuchi A, Saigenji K, Nagura H, Ohtani H (1998) CD8 T cells infiltrated within cancer cell nests as a prognostic factor in human colorectal cancer. Cancer Res 58: 3491-3494. (Pubitemid 28376536)
29. Naugler WE, Karin M (2008) The wolf in sheep's clothing: The role of interleukin-6 in immunity, inflammation and cancer. Trends Mol Med 14: 109-119.
30. O'Connell JB, Maggard MA, Ko CY (2004) Colon cancer survival rates with the new American Joint Committee on Cancer sixth edition staging. J Natl Cancer Inst 96: 1420-1425. (Pubitemid 39429665)
31. Pages F, Galon J, Dieu-Nosjean MC, Tartour E, Sautes-Fridman C, Fridman WH (2010) Immune infiltration in human tumors: A prognostic factor that should not be ignored. Oncogene 29: 1093-1102.
32. Pancione M, Forte N, Sabatino L, Tomaselli E, Parente D, Febbraro A, Colantuoni V (2009) Reduced beta-catenin and peroxisome proliferatoractivated receptor-gamma expression levels are associated with colorectal cancer metastatic progression: correlation with tumor-Associated macrophages, cyclooxygenase 2, and patient outcome. Hum Pathol 40: 714-725.
33. Pellegrini P, Berghella AM, Del Beato T, Cicia S, Adorno D, Casciani CU (1996) Disregulation in TH1 and TH2 subsets of CD4 T cells in peripheral blood of colorectal cancer patients and involvement in cancer establishment and progression. Cancer Immunol Immunother 42: 1-8.
34. Puppa G, Sonzogni A, Colombari R, Pelosi G (2010) TNM staging system of colorectal carcinoma: A critical appraisal of challenging issues. Arch Pathol Lab Med 134: 837-852.
35. Ropponen KM, Eskelinen MJ, Lipponen PK, Alhava E, Kosma VM (1997) Prognostic value of tumour-infiltrating lymphocytes (TILs) in colorectal cancer. J Pathol 182: 318-324. (Pubitemid 27285785)
36. Rothwell PM, Wilson M, Elwin CE, Norrving B, Algra A, Warlow CP, Meade TW (2010) Long-term effect of aspirin on colorectal cancer incidence and mortality: 20-year follow-up of five randomised trials. Lancet 376: 1741-1750.
37. Roxburgh CS, McMillan DC (2010) Role of systemic inflammatory response in predicting survival in patients with primary operable cancer. Future Oncol 6: 149-163.
38. Roxburgh CS, Salmond JM, Horgan PG, Oien KA, McMillan DC (2009) Tumour inflammatory infiltrate predicts survival following curative resection for node-negative colorectal cancer. Eur J Cancer 45: 2138-2145.
39. Rubie C, Frick VO, Pfeil S, Wagner M, Kollmar O, Kopp B, Graber S, Rau BM, Schilling MK (2007) Correlation of IL-8 with induction, progression and metastatic potential of colorectal cancer. World J Gastroenterol 13: 4996-5002. (Pubitemid 47496833)
40. Sharma A, Greenman J, Walker LG, Monson JR (2010) Differences in cytokine levels due to gender in colorectal cancer patients. Cytokine 50: 91-93.
41. Sobin LH, Wittekind C (eds). (2002) TNM Classification Of Malignant Tumours. Wiley-Liss: New York Strieter RM, Kunkel SL, Arenberg DA, Burdick MD, Polverini PJ (1995) Interferon gamma-inducible protein 10 (IP-10), a member of the C-X-C chemokine family, is an inhibitor of angiogenesis. Biochem Biophys Res Commun 210: 51-57.
42. Sturgeon CM, Duffy MJ, Stenman UH, Lilja H, Brunner N, Chan DW, Babaian R, Bast Jr RC, Dowell B, Esteva FJ, Haglund C, Harbeck N, Hayes DF, Holten-Andersen M, Klee GG, Lamerz R, Looijenga LH, Molina R, Nielsen HJ, Rittenhouse H, Semjonow A, Shih I, Sibley P, Soletormos G, Stephan C, Sokoll L, Hoffman BR, Diamandis EP, National Academy of Clinical Biochemistry (2008) National Academy of Clinical Biochemistry laboratory medicine practice guidelines for use of tumor markers in testicular, prostate, colorectal, breast, and ovarian cancers. Clin Chem 54: e11-e79. (Pubitemid 352777353)
43. Tanaka S, Tatsuguchi A, Futagami S, Gudis K, Wada K, Seo T, Mitsui K, Yonezawa M, Nagata K, Fujimori S, Tsukui T, Kishida T, Sakamoto C (2006) Monocyte chemoattractant protein 1 and macrophage cyclooxygenase 2 expression in colonic adenoma. Gut 55: 54-61. (Pubitemid 41820636)
44. Terzic J, Grivennikov S, Karin E, Karin M (2010) Inflammation and colon cancer. Gastroenterology 138: 2101.e5-2114.e5.
45. Tonouchi H, Miki C, Ohmori Y, Kobayashi M, Mohri Y, Tanaka K, Konishi N, Kusunoki M (2004) Serum monocyte chemoattractant protein-1 in patients with postoperative infectious complications from gastrointestinal surgery for cancer. World J Surg 28: 130-136. (Pubitemid 38299015)
46. Tonouchi H, Miki C, Tanaka K, Kusunoki M (2002) Profile of monocyte chemoattractant protein-1 circulating levels in gastric cancer patients. Scand J Gastroenterol 37: 830-833. (Pubitemid 34836821)
47. Ueda T, Shimada E, Urakawa T (1994) Serum levels of cytokines in patients with colorectal cancer: possible involvement of interleukin-6 and interleukin-8 in hematogenous metastasis. J Gastroenterol 29: 423-429. (Pubitemid 24262709)
48. von Roon AC, Reese G, Teare J, Constantinides V, Darzi AW, Tekkis PP (2007) The risk of cancer in patients with Crohn's disease. Dis Colon Rectum 50: 839-855. (Pubitemid 46870441)
49. Wang D, Dubois RN, Richmond A (2009) The role of chemokines in intestinal inflammation and cancer. Curr Opin Pharmacol 9: 688-696.
50. Waugh DJ, Wilson C (2008) The interleukin-8 pathway in cancer. Clin Cancer Res 14: 6735-6741