-
1
-
-
70949087383
-
Inflammatory bowel disease and mutations affecting the interleukin-10 receptor
-
Glocker, E. O. et al. Inflammatory bowel disease and mutations affecting the interleukin-10 receptor. N. Engl. J. Med. 361, 2033-2045 (2009).
-
(2009)
N. Engl. J. Med
, vol.361
, pp. 2033-2045
-
-
Glocker, E.O.1
-
2
-
-
84873733916
-
IL-10R polymorphisms are associated with very-early-onset ulcerative colitis
-
Moran, C. J. et al. IL-10R polymorphisms are associated with very-early-onset ulcerative colitis. Inflamm. Bowel. Dis. 19, 115-123 (2013).
-
(2013)
Inflamm. Bowel. Dis
, vol.19
, pp. 115-123
-
-
Moran, C.J.1
-
3
-
-
0027521572
-
Interleukin-10- deficient mice develop chronic enterocolitis
-
Kuhn, R., Lohler, J., Rennick, D., Rajewsky, K. & Muller, W. Interleukin-10- deficient mice develop chronic enterocolitis. Cell 75, 263-274 (1993).
-
(1993)
Cell
, vol.75
, pp. 263-274
-
-
Kuhn, R.1
Lohler, J.2
Rennick, D.3
Rajewsky, K.4
Muller, W.5
-
4
-
-
0032536530
-
The orphan receptor CRF2-4 is an essential subunit of the interleukin 10 receptor
-
Spencer, S. D. et al. The orphan receptor CRF2-4 is an essential subunit of the interleukin 10 receptor. J. Exp. Med. 187, 571-578 (1998).
-
(1998)
J. Exp. Med
, vol.187
, pp. 571-578
-
-
Spencer, S.D.1
-
5
-
-
33646397611
-
IL-23 is essential for T cell-mediated colitis and promotes inflammation via IL-17 and IL-6
-
Yen, D. et al. IL-23 is essential for T cell-mediated colitis and promotes inflammation via IL-17 and IL-6. J. Clin. Invest. 116, 1310-1316 (2006).
-
(2006)
J. Clin. Invest
, vol.116
, pp. 1310-1316
-
-
Yen, D.1
-
6
-
-
0030704726
-
A CD4 T-cell subset inhibits antigen-specific T-cell responses and prevents colitis
-
Groux, H. et al. A CD4 T-cell subset inhibits antigen-specific T-cell responses and prevents colitis. Nature 389, 737-742 (1997).
-
(1997)
Nature
, vol.389
, pp. 737-742
-
-
Groux, H.1
-
7
-
-
0036893171
-
Prevention of colitis by interleukin 10-transduced T lymphocytes in the SCID mice transfer model
-
Van Montfrans, C. et al. Prevention of colitis by interleukin 10-transduced T lymphocytes in the SCID mice transfer model. Gastroenterology 123, 1865-1876 (2002).
-
(2002)
Gastroenterology
, vol.123
, pp. 1865-1876
-
-
Van Montfrans, C.1
-
8
-
-
0038783387
-
Colitogenic Th1 cells are present in the antigen-experienced T cell pool in normal mice: Control by CD4+ regulatory T cells and IL-10
-
Asseman, C., Read, S. & Powrie, F. Colitogenic Th1 cells are present in the antigen-experienced T cell pool in normal mice: control by CD4+ regulatory T cells and IL-10. J. Immunol. 171, 971-978 (2003).
-
(2003)
J. Immunol
, vol.171
, pp. 971-978
-
-
Asseman, C.1
Read, S.2
Powrie, F.3
-
9
-
-
9244237038
-
T cell-specific inactivation of the interleukin 10 gene in mice results in enhanced T cell responses but normal innate responses to lipopolysaccharide or skin irritation
-
Roers, A. et al. T cell-specific inactivation of the interleukin 10 gene in mice results in enhanced T cell responses but normal innate responses to lipopolysaccharide or skin irritation. J. Exp. Med. 200, 1289-1297 (2004).
-
(2004)
J. Exp. Med
, vol.200
, pp. 1289-1297
-
-
Roers, A.1
-
10
-
-
41549159660
-
Regulatory T cell-derived interleukin-10 limits inflammation at environmental interfaces
-
Rubtsov, Y. P. et al. Regulatory T cell-derived interleukin-10 limits inflammation at environmental interfaces. Immunity 28, 546-558 (2008).
-
(2008)
Immunity
, vol.28
, pp. 546-558
-
-
Rubtsov, Y.P.1
-
11
-
-
70350464351
-
Interleukin 10 acts on regulatory T cells to maintain expression of the transcription factor Foxp3 and suppressive function in mice with colitis
-
Murai, M. et al. Interleukin 10 acts on regulatory T cells to maintain expression of the transcription factor Foxp3 and suppressive function in mice with colitis. Nat. Immunol. 10, 1178-1184 (2009).
-
(2009)
Nat. Immunol
, vol.10
, pp. 1178-1184
-
-
Murai, M.1
-
12
-
-
33845574337
-
Interleukin-10 derived from macrophages and/or neutrophils regulates the inflammatory response to LPS but not the response to CpG DNA
-
Siewe, L. et al. Interleukin-10 derived from macrophages and/or neutrophils regulates the inflammatory response to LPS but not the response to CpG DNA. Eur. J. Immunol. 36, 3248-3255 (2006).
-
(2006)
Eur. J. Immunol
, vol.36
, pp. 3248-3255
-
-
Siewe, L.1
-
13
-
-
75149114226
-
Monocytes/macrophages and/or neutrophils are the target of IL-10 in the LPS endotoxemia model
-
Pils, M. C. et al. Monocytes/macrophages and/or neutrophils are the target of IL-10 in the LPS endotoxemia model. Eur. J. Immunol. 40, 443-448 (2010).
-
(2010)
Eur. J. Immunol
, vol.40
, pp. 443-448
-
-
Pils, M.C.1
-
14
-
-
84900448316
-
Macrophage-restricted interleukin-10 receptor deficiency, but not IL-10 deficiency, causes severe spontaneous colitis
-
Zigmond, E. et al. Macrophage-restricted interleukin-10 receptor deficiency, but not IL-10 deficiency, causes severe spontaneous colitis. Immunity 40, 720-733 (2014).
-
(2014)
Immunity
, vol.40
, pp. 720-733
-
-
Zigmond, E.1
-
15
-
-
0029112601
-
Effects of in vivo administration of anti-IL-10 monoclonal antibody on the host defence mechanism against murine Salmonella infection
-
Arai, T. et al. Effects of in vivo administration of anti-IL-10 monoclonal antibody on the host defence mechanism against murine Salmonella infection. Immunology 85, 381-388 (1995).
-
(1995)
Immunology
, vol.85
, pp. 381-388
-
-
Arai, T.1
-
16
-
-
0029073130
-
Neutralization of IL-10 increases survival in a murine model of Klebsiella pneumonia
-
Greenberger, M. J. et al. Neutralization of IL-10 increases survival in a murine model of Klebsiella pneumonia. J. Immunol. 155, 722-729 (1995).
-
(1995)
J. Immunol
, vol.155
, pp. 722-729
-
-
Greenberger, M.J.1
-
17
-
-
0029959459
-
In the absence of endogenous IL-10, mice acutely infected with Toxoplasma gondii succumb to a lethal immune response dependent on CD4+ T cells and accompanied by overproduction of IL-12, IFN- gamma and TNF-alpha
-
Gazzinelli, R. T. et al. In the absence of endogenous IL-10, mice acutely infected with Toxoplasma gondii succumb to a lethal immune response dependent on CD4+ T cells and accompanied by overproduction of IL-12, IFN- gamma and TNF-alpha. J. Immunol. 157, 798-805 (1996).
-
(1996)
J. Immunol
, vol.157
, pp. 798-805
-
-
Gazzinelli, R.T.1
-
18
-
-
0031091727
-
Both innate and acquired immunity to Listeria monocytogenes infection are increased in IL-10-deficient mice
-
Dai, W. J., Kohler, G. & Brombacher, F. Both innate and acquired immunity to Listeria monocytogenes infection are increased in IL-10-deficient mice. J. Immunol. 158, 2259-2267 (1997).
-
(1997)
J. Immunol
, vol.158
, pp. 2259-2267
-
-
Dai, W.J.1
Kohler, G.2
Brombacher, F.3
-
19
-
-
0032942815
-
Early resistance of interleukin-10 knockout mice to acute systemic candidiasis
-
Vazquez-Torres, A., Jones-Carson, J., Wagner, R. D., Warner, T. & Balish, E. Early resistance of interleukin-10 knockout mice to acute systemic candidiasis. Infect. Immun. 67, 670-674 (1999).
-
(1999)
Infect. Immun
, vol.67
, pp. 670-674
-
-
Vazquez-Torres, A.1
Jones-Carson, J.2
Wagner, R.D.3
Warner, T.4
Balish, E.5
-
20
-
-
84898913683
-
Attenuation of intestinal inflammation in IL-10 deficient mice infected with Citrobacter rodentium
-
Dann, S. M. et al. Attenuation of intestinal inflammation in IL-10 deficient mice infected with Citrobacter rodentium. Infect. Immun. 82, 1949-1958 (2014).
-
(2014)
Infect. Immun
, vol.82
, pp. 1949-1958
-
-
Dann, S.M.1
-
21
-
-
0033230388
-
Paralysis of dendritic cell IL-12 production by microbial products prevents infection-induced immunopathology
-
Reis e Sousa, C. et al. Paralysis of dendritic cell IL-12 production by microbial products prevents infection-induced immunopathology. Immunity 11, 637-647 (1999).
-
(1999)
Immunity
, vol.11
, pp. 637-647
-
-
Reis E Sousa, C.1
-
22
-
-
0034658617
-
IL-10 is required for prevention of necrosis in the small intestine and mortality in both genetically resistant BALB/c and susceptible C57BL/6 mice following peroral infection with Toxoplasma gondii
-
Suzuki, Y. et al. IL-10 is required for prevention of necrosis in the small intestine and mortality in both genetically resistant BALB/c and susceptible C57BL/6 mice following peroral infection with Toxoplasma gondii. J. Immunol. 164, 5375-5382 (2000).
-
(2000)
J. Immunol
, vol.164
, pp. 5375-5382
-
-
Suzuki, Y.1
-
23
-
-
0031112271
-
IL- 10 is required to prevent immune hyperactivity during infection with Trypanosoma cruzi
-
Hunter, C. A. et al. IL- 10 is required to prevent immune hyperactivity during infection with Trypanosoma cruzi. J. Immunol. 158, 3311-3316 (1997).
-
(1997)
J. Immunol
, vol.158
, pp. 3311-3316
-
-
Hunter, C.A.1
-
24
-
-
28044461045
-
Citrobacter rodentium of mice and man
-
Mundy, R., MacDonald, T. T., Dougan, G., Frankel, G. & Wiles, S. Citrobacter rodentium of mice and man. Cell. Microbiol. 7, 1697-1706 (2005).
-
(2005)
Cell. Microbiol
, vol.7
, pp. 1697-1706
-
-
Mundy, R.1
Macdonald, T.T.2
Dougan, G.3
Frankel, G.4
Wiles, S.5
-
25
-
-
33749011189
-
Animal models of inflammatory bowel disease: Lessons from enteric infections
-
Eckmann, L. Animal models of inflammatory bowel disease: lessons from enteric infections. Ann. NY Acad. Sci. 1072, 28-38 (2006).
-
(2006)
Ann. NY Acad. Sci
, vol.1072
, pp. 28-38
-
-
Eckmann, L.1
-
26
-
-
84880964887
-
The Citrobacter rodentium mouse model: Studying pathogen and host contributions to infectious colitis
-
Bhinder, G. et al. The Citrobacter rodentium mouse model: studying pathogen and host contributions to infectious colitis. J. Vis. Exp. e50222 (2013).
-
(2013)
J. Vis. Exp
-
-
Bhinder, G.1
-
27
-
-
0031943618
-
The interleukin-12/interleukin-12-receptor system: Role in normal and pathologic immune responses
-
Gately, M. K. et al. The interleukin-12/interleukin-12-receptor system: role in normal and pathologic immune responses. Annu. Rev. Immunol. 16, 495-521 (1998).
-
(1998)
Annu. Rev. Immunol
, vol.16
, pp. 495-521
-
-
Gately, M.K.1
-
28
-
-
33845606612
-
IL-12p40: An inherently agonistic cytokine
-
Cooper, A. M. & Khader, S. A. IL-12p40: an inherently agonistic cytokine. Trends. Immunol. 28, 33-38 (2007).
-
(2007)
Trends. Immunol
, vol.28
, pp. 33-38
-
-
Cooper, A.M.1
Khader, S.A.2
-
29
-
-
84883172356
-
Notch2- dependent classical dendritic cells orchestrate intestinal immunity to attaching-and-effacing bacterial pathogens
-
Satpathy, A. T. et al. Notch2- dependent classical dendritic cells orchestrate intestinal immunity to attaching-and-effacing bacterial pathogens. Nat. Immunol. 14, 937-948 (2013).
-
(2013)
Nat. Immunol
, vol.14
, pp. 937-948
-
-
Satpathy, A.T.1
-
30
-
-
84864659874
-
HVEM signalling at mucosal barriers provides host defence against pathogenic bacteria
-
Shui, J. W. et al. HVEM signalling at mucosal barriers provides host defence against pathogenic bacteria. Nature 488, 222-225 (2012).
-
(2012)
Nature
, vol.488
, pp. 222-225
-
-
Shui, J.W.1
-
31
-
-
21844444831
-
New IL-12-family members: IL-23 and IL-27, cytokines with divergent functions
-
Hunter, C. A. New IL-12-family members: IL-23 and IL-27, cytokines with divergent functions. Nat. Rev. Immunol. 5, 521-531 (2005).
-
(2005)
Nat. Rev. Immunol
, vol.5
, pp. 521-531
-
-
Hunter, C.A.1
-
32
-
-
84874082076
-
CX(3)CR1(+) macrophages support IL-22 production by innate lymphoid cells during infection with Citrobacter rodentium
-
Manta, C. et al. CX(3)CR1(+) macrophages support IL-22 production by innate lymphoid cells during infection with Citrobacter rodentium. Mucosal Immunol. 6, 177-188 (2012).
-
(2012)
Mucosal Immunol
, vol.6
, pp. 177-188
-
-
Manta, C.1
-
33
-
-
0033802512
-
Human monocytes express CD163, which is upregulated by IL-10 and identical to p155
-
Sulahian, T. H. et al. Human monocytes express CD163, which is upregulated by IL-10 and identical to p155. Cytokine 12, 1312-1321 (2000).
-
(2000)
Cytokine
, vol.12
, pp. 1312-1321
-
-
Sulahian, T.H.1
-
34
-
-
0026094306
-
Interleukin 10(IL-10) inhibits cytokine synthesis by human monocytes: An autoregulatory role of IL-10 produced by monocytes
-
de Waal Malefyt, R., Abrams, J., Bennett, B., Figdor, C. G. & de Vries, J. E. Interleukin 10(IL-10) inhibits cytokine synthesis by human monocytes: an autoregulatory role of IL-10 produced by monocytes. J. Exp. Med. 174, 1209-1220 (1991).
-
(1991)
J. Exp. Med
, vol.174
, pp. 1209-1220
-
-
De Waal Malefyt, R.1
Abrams, J.2
Bennett, B.3
Figdor, C.G.4
De Vries, J.E.5
-
35
-
-
77649184739
-
The regulation of IL-10 production by immune cells
-
Saraiva, M. & O'Garra, A. The regulation of IL-10 production by immune cells. Nat. Rev. Immunol. 10, 170-181 (2010).
-
(2010)
Nat. Rev. Immunol
, vol.10
, pp. 170-181
-
-
Saraiva, M.1
O'Garra, A.2
-
36
-
-
84861972274
-
Regulated virulence controls the ability of a pathogen to compete with the gut microbiota
-
Kamada, N. et al. Regulated virulence controls the ability of a pathogen to compete with the gut microbiota. Science New York, NY 336, 1325-1329 (2012).
-
(2012)
Science New York, NY
, vol.336
, pp. 1325-1329
-
-
Kamada, N.1
-
37
-
-
34548764423
-
Lamina propria macrophages and dendritic cells differentially induce regulatory and interleukin 17-producing T cell responses
-
Denning, T. L., Wang, Y. C., Patel, S. R., Williams, I. R. & Pulendran, B. Lamina propria macrophages and dendritic cells differentially induce regulatory and interleukin 17-producing T cell responses. Nat. Immunol. 8, 1086-1094 (2007).
-
(2007)
Nat. Immunol
, vol.8
, pp. 1086-1094
-
-
Denning, T.L.1
Wang, Y.C.2
Patel, S.R.3
Williams, I.R.4
Pulendran, B.5
-
38
-
-
78650412729
-
Commensal microbiota induce LPS hyporesponsiveness in colonic macrophages via the production of IL-10
-
Ueda, Y. et al. Commensal microbiota induce LPS hyporesponsiveness in colonic macrophages via the production of IL-10. Int. Immunol. 22, 953-962 (2010).
-
(2010)
Int. Immunol
, vol.22
, pp. 953-962
-
-
Ueda, Y.1
-
39
-
-
84055200171
-
CX3CR1 regulates intestinal macrophage homeostasis, bacterial translocation, and colitogenic Th17 responses in mice
-
Medina-Contreras, O. et al. CX3CR1 regulates intestinal macrophage homeostasis, bacterial translocation, and colitogenic Th17 responses in mice. J. Clin. Invest. 121, 4787-4795 (2011).
-
(2011)
J. Clin. Invest
, vol.121
, pp. 4787-4795
-
-
Medina-Contreras, O.1
-
40
-
-
84856815290
-
Inflammation switches the differentiation program of Ly6Chi monocytes from antiinflammatory macrophages to inflammatory dendritic cells in the colon
-
Rivollier, A., He, J., Kole, A., Valatas, V. & Kelsall, B. L. Inflammation switches the differentiation program of Ly6Chi monocytes from antiinflammatory macrophages to inflammatory dendritic cells in the colon. J. Exp. Med. 209, 139-155 (2012).
-
(2012)
J. Exp. Med
, vol.209
, pp. 139-155
-
-
Rivollier, A.1
He, J.2
Kole, A.3
Valatas, V.4
Kelsall, B.L.5
-
41
-
-
33747089041
-
Differential activity of IL-12 and IL-23 in mucosal and systemic innate immune pathology
-
Uhlig, H. H. et al. Differential activity of IL-12 and IL-23 in mucosal and systemic innate immune pathology. Immunity 25, 309-318 (2006).
-
(2006)
Immunity
, vol.25
, pp. 309-318
-
-
Uhlig, H.H.1
-
42
-
-
33750505009
-
Interleukin-23 drives innate and T cell-mediated intestinal inflammation
-
Hue, S. et al. Interleukin-23 drives innate and T cell-mediated intestinal inflammation. J. Exp. Med. 203, 2473-2483 (2006).
-
(2006)
J. Exp. Med
, vol.203
, pp. 2473-2483
-
-
Hue, S.1
-
43
-
-
0035877257
-
Ubiquitous transgenic expression of the IL-23 subunit p19 induces multiorgan inflammation, runting, infertility, and premature death
-
Wiekowski, M. T. et al. Ubiquitous transgenic expression of the IL-23 subunit p19 induces multiorgan inflammation, runting, infertility, and premature death. J. Immunol. 166, 7563-7570 (2001).
-
(2001)
J. Immunol
, vol.166
, pp. 7563-7570
-
-
Wiekowski, M.T.1
-
44
-
-
84869455238
-
MyD88 signalling in colonic mononuclear phagocytes drives colitis in IL-10-deficient mice
-
Hoshi, N. et al. MyD88 signalling in colonic mononuclear phagocytes drives colitis in IL-10-deficient mice. Nat. Commun. 3, 1120 (2012).
-
(2012)
Nat. Commun
, vol.3
, pp. 1120
-
-
Hoshi, N.1
-
45
-
-
84900428511
-
Interleukin-10 receptor signaling in innate immune cells regulates mucosal immune tolerance and anti-inflammatory macrophage function
-
Shouval, D. S. et al. Interleukin-10 receptor signaling in innate immune cells regulates mucosal immune tolerance and anti-inflammatory macrophage function. Immunity 40, 706-719 (2014).
-
(2014)
Immunity
, vol.40
, pp. 706-719
-
-
Shouval, D.S.1
-
46
-
-
70350093623
-
Th1/Th17 immune response is induced by mesenteric lymph node dendritic cells in Crohn's disease
-
Sakuraba, A. et al. Th1/Th17 immune response is induced by mesenteric lymph node dendritic cells in Crohn's disease. Gastroenterology 137, 1736-1745 (2009).
-
(2009)
Gastroenterology
, vol.137
, pp. 1736-1745
-
-
Sakuraba, A.1
-
47
-
-
0037320462
-
Peyer's patch is the essential site in initiating murine acute and lethal graft-versus-host reaction
-
Murai, M. et al. Peyer's patch is the essential site in initiating murine acute and lethal graft-versus-host reaction. Nat. Immunol. 4, 154-160 (2003).
-
(2003)
Nat. Immunol
, vol.4
, pp. 154-160
-
-
Murai, M.1
-
48
-
-
84890040690
-
TSC1 regulates the balance between effector and regulatory T cells
-
Park, Y. et al. TSC1 regulates the balance between effector and regulatory T cells. J. Clin. Invest. 123, 5165-5178 (2013).
-
(2013)
J. Clin. Invest
, vol.123
, pp. 5165-5178
-
-
Park, Y.1
-
49
-
-
28744458859
-
Bioconductor: Open software development for computational biology and bioinformatics
-
Gentleman, R. C. et al. Bioconductor: open software development for computational biology and bioinformatics. Genome. Biol. 5, R80 (2004).
-
(2004)
Genome. Biol
, vol.5
, pp. R80
-
-
Gentleman, R.C.1
|