메뉴 건너뛰기




Volumn 63, Issue 5, 2014, Pages 419-435

Interleukin 12: Still a promising candidate for tumor immunotherapy?

Author keywords

Cancer immunotherapy; Cytokine; Gene therapy; Interleukin 12

Indexed keywords

5 AZA 2' DEOXYCYTIDINE; ANGIOGENESIS INHIBITOR; CANCER ANTIBODY; CETUXIMAB; CISPLATIN; CPG OLIGODEOXYNUCLEOTIDE; CYCLOPHOSPHAMIDE; DOXORUBICIN; FLUOROURACIL; IMMUNOMODULATING AGENT; INTERFERON; INTERLEUKIN 10; INTERLEUKIN 12; MITOMYCIN; MITOXANTRONE; MONOCLONAL ANTIBODY; PACLITAXEL; PEPTIDE VACCINE; RECOMBINANT GRANULOCYTE COLONY STIMULATING FACTOR; RECOMBINANT GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; RECOMBINANT INTERLEUKIN 12; RECOMBINANT INTERLEUKIN 18; RECOMBINANT INTERLEUKIN 2; RECOMBINANT TUMOR NECROSIS FACTOR ALPHA; RETINOIC ACID; SORAFENIB; SUNITINIB; TRANSFORMING GROWTH FACTOR BETA; TUMOR VACCINE; UNINDEXED DRUG;

EID: 84899950432     PISSN: 03407004     EISSN: 14320851     Source Type: Journal    
DOI: 10.1007/s00262-014-1523-1     Document Type: Review
Times cited : (370)

References (188)
  • 1
    • 0025028960 scopus 로고
    • Purification to homogeneity and partial characterization of cytotoxic lymphocyte maturation factor from human B-lymphoblastoid cells
    • 54627 2204066
    • Stern AS, Podlaski FJ, Hulmes JD et al (1990) Purification to homogeneity and partial characterization of cytotoxic lymphocyte maturation factor from human B-lymphoblastoid cells. Proc Natl Acad Sci USA 87:6808-6812
    • (1990) Proc Natl Acad Sci USA , vol.87 , pp. 6808-6812
    • Stern, A.S.1    Podlaski, F.J.2    Hulmes, J.D.3
  • 2
    • 0024467154 scopus 로고
    • Identification and purification of natural killer cell stimulatory factor (NKSF), a cytokine with multiple biologic effects on human lymphocytes
    • 2504877
    • Kobayashi M, Fitz L, Ryan M et al (1989) Identification and purification of natural killer cell stimulatory factor (NKSF), a cytokine with multiple biologic effects on human lymphocytes. J Exp Med 170:827-845
    • (1989) J Exp Med , vol.170 , pp. 827-845
    • Kobayashi, M.1    Fitz, L.2    Ryan, M.3
  • 3
    • 0346365485 scopus 로고    scopus 로고
    • Natural mechanisms protecting against cancer
    • 14687712
    • Jakobisiak M, Lasek W, Golab J (2003) Natural mechanisms protecting against cancer. Immunol Lett 90:103-122
    • (2003) Immunol Lett , vol.90 , pp. 103-122
    • Jakobisiak, M.1    Lasek, W.2    Golab, J.3
  • 4
    • 13344259977 scopus 로고    scopus 로고
    • Interleukin-12 is produced by dendritic cells and mediates T helper 1 development as well as interferon-gamma production by T helper 1 cells
    • 8605935
    • Heufler C, Koch F, Stanzl U et al (1996) Interleukin-12 is produced by dendritic cells and mediates T helper 1 development as well as interferon-gamma production by T helper 1 cells. Eur J Immunol 26:659-668
    • (1996) Eur J Immunol , vol.26 , pp. 659-668
    • Heufler, C.1    Koch, F.2    Stanzl, U.3
  • 5
    • 84886900071 scopus 로고    scopus 로고
    • Human CD1c + dendritic cells secrete high levels of IL-12 and potently prime cytotoxic T cell responses
    • Nizzoli G, Krietsch J, Weick A et al (2013) Human CD1c + dendritic cells secrete high levels of IL-12 and potently prime cytotoxic T cell responses. Blood 122:932-942
    • (2013) Blood , vol.122 , pp. 932-942
    • Nizzoli, G.1    Krietsch, J.2    Weick, A.3
  • 6
    • 0027336689 scopus 로고
    • Development of TH1 CD4+ T cells through IL-12 produced by Listeria-induced macrophages
    • 8097338
    • Hsieh CS, Macatonia SE, Tripp CS, Wolf SF, O'Garra A, Murphy KM (1993) Development of TH1 CD4+ T cells through IL-12 produced by Listeria-induced macrophages. Science 260:547-549
    • (1993) Science , vol.260 , pp. 547-549
    • Hsieh, C.S.1    Macatonia, S.E.2    Tripp, C.S.3    Wolf, S.F.4    O'Garra, A.5    Murphy, K.M.6
  • 8
    • 84870799837 scopus 로고    scopus 로고
    • Identification and characterization of polyclonal alphabeta-T cells with dendritic cell properties
    • 3528357 23187623
    • Kuka M, Munitic I, Ashwell JD (2012) Identification and characterization of polyclonal alphabeta-T cells with dendritic cell properties. Nat Commun 3:1223
    • (2012) Nat Commun , vol.3 , pp. 1223
    • Kuka, M.1    Munitic, I.2    Ashwell, J.D.3
  • 9
    • 0031837912 scopus 로고    scopus 로고
    • The regulation and biological activity of interleukin 12
    • 9643557
    • Lee SM, Suen Y, Qian J, Knoppel E, Cairo MS (1998) The regulation and biological activity of interleukin 12. Leuk Lymphoma 29:427-438
    • (1998) Leuk Lymphoma , vol.29 , pp. 427-438
    • Lee, S.M.1    Suen, Y.2    Qian, J.3    Knoppel, E.4    Cairo, M.S.5
  • 11
    • 77950909696 scopus 로고    scopus 로고
    • Interleukin 12 a key immunoregulatory cytokine in infection applications
    • 2869233 20479986
    • Hamza T, Barnett JB, Li B (2010) Interleukin 12 a key immunoregulatory cytokine in infection applications. Int J Mol Sci 11:789-806
    • (2010) Int J Mol Sci , vol.11 , pp. 789-806
    • Hamza, T.1    Barnett, J.B.2    Li, B.3
  • 12
    • 70350439428 scopus 로고    scopus 로고
    • Interleukin-12 receptor beta2: From cytokine receptor to gatekeeper gene in human B-cell malignancies
    • 19720917
    • Pistoia V, Cocco C, Airoldi I (2009) Interleukin-12 receptor beta2: from cytokine receptor to gatekeeper gene in human B-cell malignancies. J Clin Oncol 27:4809-4816
    • (2009) J Clin Oncol , vol.27 , pp. 4809-4816
    • Pistoia, V.1    Cocco, C.2    Airoldi, I.3
  • 13
    • 15844396183 scopus 로고    scopus 로고
    • Requirement for Stat4 in interleukin-12-mediated responses of natural killer and T cells
    • 8700208
    • Thierfelder WE, van Deursen JM, Yamamoto K et al (1996) Requirement for Stat4 in interleukin-12-mediated responses of natural killer and T cells. Nature 382:171-174
    • (1996) Nature , vol.382 , pp. 171-174
    • Thierfelder, W.E.1    Van Deursen, J.M.2    Yamamoto, K.3
  • 14
    • 0033697454 scopus 로고    scopus 로고
    • CD40 triggering of heterodimeric IL-12 p70 production by dendritic cells in vivo requires a microbial priming signal
    • 11070164
    • Schulz O, Edwards AD, Schito M, Aliberti J, Manickasingham S, Sher A, Reis e Sousa C (2000) CD40 triggering of heterodimeric IL-12 p70 production by dendritic cells in vivo requires a microbial priming signal. Immunity 13:453-462
    • (2000) Immunity , vol.13 , pp. 453-462
    • Schulz, O.1    Edwards, A.D.2    Schito, M.3    Aliberti, J.4    Manickasingham, S.5    Sher, A.6    Reis Sousa E, C.7
  • 16
    • 0034872151 scopus 로고    scopus 로고
    • IL-1 beta induces dendritic cells to produce IL-12
    • 11470775
    • Wesa AK, Galy A (2001) IL-1 beta induces dendritic cells to produce IL-12. Int Immunol 13:1053-1061
    • (2001) Int Immunol , vol.13 , pp. 1053-1061
    • Wesa, A.K.1    Galy, A.2
  • 17
    • 0030460164 scopus 로고    scopus 로고
    • Interleukin-12 production by dendritic cells the role of CD40-CD40L interactions in Th1 T-cell responses
    • 8958922
    • Kelsall BL, Stuber E, Neurath M, Strober W (1996) Interleukin-12 production by dendritic cells. The role of CD40-CD40L interactions in Th1 T-cell responses. Ann N Y Acad Sci 795:116-126
    • (1996) Ann N y Acad Sci , vol.795 , pp. 116-126
    • Kelsall, B.L.1    Stuber, E.2    Neurath, M.3    Strober, W.4
  • 18
    • 0035954824 scopus 로고    scopus 로고
    • Functional maturation of dendritic cells by exposure to CD40L transgenic tumor cells, fibroblasts or keratinocytes
    • 11403919
    • Felzmann T, Buchberger M, Lehner M, Printz D, Kircheis R, Wagner E, Gadner H, Holter W (2001) Functional maturation of dendritic cells by exposure to CD40L transgenic tumor cells, fibroblasts or keratinocytes. Cancer Lett 168:145-154
    • (2001) Cancer Lett , vol.168 , pp. 145-154
    • Felzmann, T.1    Buchberger, M.2    Lehner, M.3    Printz, D.4    Kircheis, R.5    Wagner, E.6    Gadner, H.7    Holter, W.8
  • 19
    • 0032080850 scopus 로고    scopus 로고
    • Type i IFNs inhibit human dendritic cell IL-12 production and Th1 cell development
    • 9574532
    • McRae BL, Semnani RT, Hayes MP, van Seventer GA (1998) Type I IFNs inhibit human dendritic cell IL-12 production and Th1 cell development. J Immunol 160:4298-4304
    • (1998) J Immunol , vol.160 , pp. 4298-4304
    • McRae, B.L.1    Semnani, R.T.2    Hayes, M.P.3    Van Seventer, G.A.4
  • 20
    • 0032770957 scopus 로고    scopus 로고
    • Tumor-associated transforming growth factor-beta and interleukin-10 contribute to a systemic Th2 immune phenotype in pancreatic carcinoma patients
    • 1866873 10433946
    • Bellone G, Turletti A, Artusio E, Mareschi K, Carbone A, Tibaudi D, Robecchi A, Emanuelli G, Rodeck U (1999) Tumor-associated transforming growth factor-beta and interleukin-10 contribute to a systemic Th2 immune phenotype in pancreatic carcinoma patients. Am J Pathol 155:537-547
    • (1999) Am J Pathol , vol.155 , pp. 537-547
    • Bellone, G.1    Turletti, A.2    Artusio, E.3    Mareschi, K.4    Carbone, A.5    Tibaudi, D.6    Robecchi, A.7    Emanuelli, G.8    Rodeck, U.9
  • 21
    • 3442889057 scopus 로고    scopus 로고
    • Regulation of interleukin-12 gene expression and its anti-tumor activities by prostaglandin E2 derived from mammary carcinomas
    • 2965202 15123779
    • Mitsuhashi M, Liu J, Cao S, Shi X, Ma X (2004) Regulation of interleukin-12 gene expression and its anti-tumor activities by prostaglandin E2 derived from mammary carcinomas. J Leukoc Biol 76:322-332
    • (2004) J Leukoc Biol , vol.76 , pp. 322-332
    • Mitsuhashi, M.1    Liu, J.2    Cao, S.3    Shi, X.4    Ma, X.5
  • 22
    • 84866412983 scopus 로고    scopus 로고
    • Immunology: TIM3 suppresses antitumour DCs
    • 22918413
    • Alderton GK (2012) Immunology: TIM3 suppresses antitumour DCs. Nat Rev Cancer 12:584
    • (2012) Nat Rev Cancer , vol.12 , pp. 584
    • Alderton, G.K.1
  • 23
    • 84866694932 scopus 로고    scopus 로고
    • CD4+ CD25+ Treg derived from hepatocellular carcinoma mice inhibits tumor immunity
    • 23000301
    • Chen X, Du Y, Huang Z (2012) CD4+ CD25+ Treg derived from hepatocellular carcinoma mice inhibits tumor immunity. Immunol Lett 148:83-89
    • (2012) Immunol Lett , vol.148 , pp. 83-89
    • Chen, X.1    Du, Y.2    Huang, Z.3
  • 26
    • 0033381309 scopus 로고    scopus 로고
    • Identification of IFN-gamma-producing cells in IL-12/IL-18-treated mice
    • 10648125
    • Otani T, Nakamura S, Toki M, Motoda R, Kurimoto M, Orita K (1999) Identification of IFN-gamma-producing cells in IL-12/IL-18-treated mice. Cell Immunol 198:111-119
    • (1999) Cell Immunol , vol.198 , pp. 111-119
    • Otani, T.1    Nakamura, S.2    Toki, M.3    Motoda, R.4    Kurimoto, M.5    Orita, K.6
  • 27
    • 0027483008 scopus 로고
    • Interleukin-12 promotes the proliferation and cytolytic maturation of immune effectors: Implications for the immunotherapy of cancer
    • Zeh HJ III, Hurd S, Storkus WJ, Lotze MT (1993) Interleukin-12 promotes the proliferation and cytolytic maturation of immune effectors: implications for the immunotherapy of cancer. J Immunother Emphas Tumor Immunol 14:155-161
    • (1993) J Immunother Emphas Tumor Immunol , vol.14 , pp. 155-161
    • Zeh III, H.J.1    Hurd, S.2    Storkus, W.J.3    Lotze, M.T.4
  • 29
    • 0036791488 scopus 로고    scopus 로고
    • IL-12 enhances the natural killer cell cytokine response to Ab-coated tumor cells
    • 151155 12370276
    • Parihar R, Dierksheide J, Hu Y, Carson WE (2002) IL-12 enhances the natural killer cell cytokine response to Ab-coated tumor cells. J Clin Invest 110:983-992
    • (2002) J Clin Invest , vol.110 , pp. 983-992
    • Parihar, R.1    Dierksheide, J.2    Hu, Y.3    Carson, W.E.4
  • 30
    • 84865799326 scopus 로고    scopus 로고
    • Cetuximab therapy in head and neck cancer: Immune modulation with interleukin-12 and other natural killer cell-activating cytokines
    • 3432674 22770960
    • Luedke E, Jaime-Ramirez AC, Bhave N, Roda J, Choudhary MM, Kumar B, Teknos TN, Carson WE III (2012) Cetuximab therapy in head and neck cancer: immune modulation with interleukin-12 and other natural killer cell-activating cytokines. Surgery 152:431-440
    • (2012) Surgery , vol.152 , pp. 431-440
    • Luedke, E.1    Jaime-Ramirez, A.C.2    Bhave, N.3    Roda, J.4    Choudhary, M.M.5    Kumar, B.6    Teknos, T.N.7    Carson III, W.E.8
  • 31
    • 0032145231 scopus 로고    scopus 로고
    • LPS-stimulated SJL macrophages produce IL-12 and IL-18 that inhibit IgE production in vitro by induction of IFN-gamma production from CD3intIL-2R beta + T cells
    • 9686615
    • Yoshimoto T, Nagai N, Ohkusu K, Ueda H, Okamura H, Nakanishi K (1998) LPS-stimulated SJL macrophages produce IL-12 and IL-18 that inhibit IgE production in vitro by induction of IFN-gamma production from CD3intIL-2R beta + T cells. J Immunol 161:1483-1492
    • (1998) J Immunol , vol.161 , pp. 1483-1492
    • Yoshimoto, T.1    Nagai, N.2    Ohkusu, K.3    Ueda, H.4    Okamura, H.5    Nakanishi, K.6
  • 32
    • 0030475607 scopus 로고    scopus 로고
    • A role for the interferon-inducible protein 10 in inhibition of angiogenesis by interleukin-12
    • 8958926
    • Angiolillo AL, Sgadari C, Tosato G (1996) A role for the interferon-inducible protein 10 in inhibition of angiogenesis by interleukin-12. Ann N Y Acad Sci 795:158-167
    • (1996) Ann N y Acad Sci , vol.795 , pp. 158-167
    • Angiolillo, A.L.1    Sgadari, C.2    Tosato, G.3
  • 33
    • 84879696103 scopus 로고    scopus 로고
    • Collapse of the tumor stroma is triggered by IL-12 induction of Fas
    • 23568260
    • Kerkar SP, Leonardi AJ, van Panhuys N et al (2013) Collapse of the tumor stroma is triggered by IL-12 induction of Fas. Mol Ther 21:1369-1377
    • (2013) Mol Ther , vol.21 , pp. 1369-1377
    • Kerkar, S.P.1    Leonardi, A.J.2    Van Panhuys, N.3
  • 34
    • 84055217292 scopus 로고    scopus 로고
    • IL-12 triggers a programmatic change in dysfunctional myeloid-derived cells within mouse tumors
    • 3226001 22056381
    • Kerkar SP, Goldszmid RS, Muranski P et al (2011) IL-12 triggers a programmatic change in dysfunctional myeloid-derived cells within mouse tumors. J Clin Invest 121:4746-4757
    • (2011) J Clin Invest , vol.121 , pp. 4746-4757
    • Kerkar, S.P.1    Goldszmid, R.S.2    Muranski, P.3
  • 35
    • 0032107371 scopus 로고    scopus 로고
    • Exogenous recombinant human IL-12 augments MHC class i antigen expression on human cancer cells in vitro
    • 9823783
    • Suzuki S, Umezu Y, Saijo Y, Satoh G, Abe Y, Satoh K, Nukiwa T (1998) Exogenous recombinant human IL-12 augments MHC class I antigen expression on human cancer cells in vitro. Tohoku J Exp Med 185:223-226
    • (1998) Tohoku J Exp Med , vol.185 , pp. 223-226
    • Suzuki, S.1    Umezu, Y.2    Saijo, Y.3    Satoh, G.4    Abe, Y.5    Satoh, K.6    Nukiwa, T.7
  • 36
    • 0033124626 scopus 로고    scopus 로고
    • Antitumor effects of interleukin-12 in pre-clinical and early clinical studies (review)
    • 10202188
    • Golab J, Zagozdzon R (1999) Antitumor effects of interleukin-12 in pre-clinical and early clinical studies (review). Int J Mol Med 3:537-544
    • (1999) Int J Mol Med , vol.3 , pp. 537-544
    • Golab, J.1    Zagozdzon, R.2
  • 38
    • 84859701005 scopus 로고    scopus 로고
    • IL-12 upregulates TIM-3 expression and induces T cell exhaustion in patients with follicular B cell non-Hodgkin lymphoma
    • 3314462 22426209
    • Yang ZZ, Grote DM, Ziesmer SC, Niki T, Hirashima M, Novak AJ, Witzig TE, Ansell SM (2012) IL-12 upregulates TIM-3 expression and induces T cell exhaustion in patients with follicular B cell non-Hodgkin lymphoma. J Clin Invest 122:1271-1282
    • (2012) J Clin Invest , vol.122 , pp. 1271-1282
    • Yang, Z.Z.1    Grote, D.M.2    Ziesmer, S.C.3    Niki, T.4    Hirashima, M.5    Novak, A.J.6    Witzig, T.E.7    Ansell, S.M.8
  • 39
    • 84875827526 scopus 로고    scopus 로고
    • Tim-3 alters the balance of IL-12/IL-23 and drives TH17 cells: Role in hepatitis B vaccine failure during hepatitis C infection
    • 23499521
    • Wang JM, Ma CJ, Li GY et al (2013) Tim-3 alters the balance of IL-12/IL-23 and drives TH17 cells: role in hepatitis B vaccine failure during hepatitis C infection. Vaccine 31:2238-2245
    • (2013) Vaccine , vol.31 , pp. 2238-2245
    • Wang, J.M.1    Ma, C.J.2    Li, G.Y.3
  • 41
    • 1642566054 scopus 로고    scopus 로고
    • Candidate genes associated with tumor regression mediated by intratumoral IL-12 electroporation gene therapy
    • 15006601
    • Li S, Xia X, Mellieon FM, Liu J, Steele S (2004) Candidate genes associated with tumor regression mediated by intratumoral IL-12 electroporation gene therapy. Mol Ther 9:347-354
    • (2004) Mol Ther , vol.9 , pp. 347-354
    • Li, S.1    Xia, X.2    Mellieon, F.M.3    Liu, J.4    Steele, S.5
  • 42
    • 84884812786 scopus 로고    scopus 로고
    • Antiangiogenic therapy promoted metastasis of hepatocellular carcinoma by suppressing host-derived interleukin-12b in mouse models
    • Zhu XD, Sun HC, Xu HX et al (2013) Antiangiogenic therapy promoted metastasis of hepatocellular carcinoma by suppressing host-derived interleukin-12b in mouse models. Angiogenesis 16:809-820
    • (2013) Angiogenesis , vol.16 , pp. 809-820
    • Zhu, X.D.1    Sun, H.C.2    Xu, H.X.3
  • 43
    • 0032400932 scopus 로고    scopus 로고
    • Recruitment of hepatic NK cells by IL-12 is dependent on IFN-gamma and VCAM-1 and is rapidly down-regulated by a mechanism involving T cells and expression of Fas
    • 9834083
    • Fogler WE, Volker K, Watanabe M, Wigginton JM, Roessler P, Brunda MJ, Ortaldo JR, Wiltrout RH (1998) Recruitment of hepatic NK cells by IL-12 is dependent on IFN-gamma and VCAM-1 and is rapidly down-regulated by a mechanism involving T cells and expression of Fas. J Immunol 161:6014-6021
    • (1998) J Immunol , vol.161 , pp. 6014-6021
    • Fogler, W.E.1    Volker, K.2    Watanabe, M.3    Wigginton, J.M.4    Roessler, P.5    Brunda, M.J.6    Ortaldo, J.R.7    Wiltrout, R.H.8
  • 46
    • 2642599039 scopus 로고    scopus 로고
    • Augmented antitumor effects of combination therapy with interleukin-12, cisplatin, and tumor necrosis factor-alpha in a murine melanoma model
    • 9494557
    • Zagozdzon R, Stoklosa T, Golab J, Giermasz A, Dabrowska A, Lasek W, Jakobisiak M (1997) Augmented antitumor effects of combination therapy with interleukin-12, cisplatin, and tumor necrosis factor-alpha in a murine melanoma model. Anticancer Res 17:4493-4498
    • (1997) Anticancer Res , vol.17 , pp. 4493-4498
    • Zagozdzon, R.1    Stoklosa, T.2    Golab, J.3    Giermasz, A.4    Dabrowska, A.5    Lasek, W.6    Jakobisiak, M.7
  • 47
    • 0028837129 scopus 로고
    • Administration of systemic or local interleukin-2 enhances the anti-tumor effects of interleukin-12 gene therapy
    • 7861776
    • Pappo I, Tahara H, Robbins PD, Gately MK, Wolf SF, Barnea A, Lotze MT (1995) Administration of systemic or local interleukin-2 enhances the anti-tumor effects of interleukin-12 gene therapy. J Surg Res 58:218-226
    • (1995) J Surg Res , vol.58 , pp. 218-226
    • Pappo, I.1    Tahara, H.2    Robbins, P.D.3    Gately, M.K.4    Wolf, S.F.5    Barnea, A.6    Lotze, M.T.7
  • 48
    • 0028084718 scopus 로고
    • Lysis of neuroblastoma cell lines by human natural killer cells activated by interleukin-2 and interleukin-12
    • 7906963
    • Rossi AR, Pericle F, Rashleigh S, Janiec J, Djeu JY (1994) Lysis of neuroblastoma cell lines by human natural killer cells activated by interleukin-2 and interleukin-12. Blood 83:1323-1328
    • (1994) Blood , vol.83 , pp. 1323-1328
    • Rossi, A.R.1    Pericle, F.2    Rashleigh, S.3    Janiec, J.4    Djeu, J.Y.5
  • 49
    • 12144288325 scopus 로고    scopus 로고
    • Complete tumour regressions induced by vaccination with IL-12 gene-transduced tumour cells in combination with IL-15 in a melanoma model in mice
    • 14605763
    • Lasek W, Basak G, Switaj T et al (2004) Complete tumour regressions induced by vaccination with IL-12 gene-transduced tumour cells in combination with IL-15 in a melanoma model in mice. Cancer Immunol Immunother 53:363-372
    • (2004) Cancer Immunol Immunother , vol.53 , pp. 363-372
    • Lasek, W.1    Basak, G.2    Switaj, T.3
  • 50
    • 84872225254 scopus 로고    scopus 로고
    • Sustained effector function of IL-12/15/18-preactivated NK cells against established tumors
    • 3526364 23209317
    • Ni J, Miller M, Stojanovic A, Garbi N, Cerwenka A (2012) Sustained effector function of IL-12/15/18-preactivated NK cells against established tumors. J Exp Med 209:2351-2365
    • (2012) J Exp Med , vol.209 , pp. 2351-2365
    • Ni, J.1    Miller, M.2    Stojanovic, A.3    Garbi, N.4    Cerwenka, A.5
  • 52
    • 0031905393 scopus 로고    scopus 로고
    • Granulocyte-macrophage colony-stimulating factor potentiates antitumor activity of interleukin-12 in melanoma model in mice
    • 9486559
    • Golab J, Stoklosa T, Zagozdzon R et al (1998) Granulocyte-macrophage colony-stimulating factor potentiates antitumor activity of interleukin-12 in melanoma model in mice. Tumour Biol 19:77-87
    • (1998) Tumour Biol , vol.19 , pp. 77-87
    • Golab, J.1    Stoklosa, T.2    Zagozdzon, R.3
  • 53
    • 6844259872 scopus 로고    scopus 로고
    • G-CSF prevents the suppression of bone marrow hematopoiesis induced by IL-12 and augments its antitumor activity in a melanoma model in mice
    • 9541685
    • Golab J, Stoklosa T, Zagozdzon R et al (1998) G-CSF prevents the suppression of bone marrow hematopoiesis induced by IL-12 and augments its antitumor activity in a melanoma model in mice. Ann Oncol 9:63-69
    • (1998) Ann Oncol , vol.9 , pp. 63-69
    • Golab, J.1    Stoklosa, T.2    Zagozdzon, R.3
  • 54
    • 0032100515 scopus 로고    scopus 로고
    • Erythropoietin prevents the development of interleukin-12-induced anemia and thrombocytopenia but does not decrease its antitumor activity in mice
    • 9596689
    • Golab J, Zagozdzon R, Stoklosa T, Jakobisiak M, Pojda Z, Machaj E (1998) Erythropoietin prevents the development of interleukin-12-induced anemia and thrombocytopenia but does not decrease its antitumor activity in mice. Blood 91:4387-4388
    • (1998) Blood , vol.91 , pp. 4387-4388
    • Golab, J.1    Zagozdzon, R.2    Stoklosa, T.3    Jakobisiak, M.4    Pojda, Z.5    Machaj, E.6
  • 55
    • 45549097962 scopus 로고    scopus 로고
    • Multilineage hematopoietic recovery with concomitant antitumor effects using low dose Interleukin-12 in myelosuppressed tumor-bearing mice
    • 2424034 18489769
    • Basile LA, Gallaher TK, Shibata D, Miller JD, Douer D (2008) Multilineage hematopoietic recovery with concomitant antitumor effects using low dose Interleukin-12 in myelosuppressed tumor-bearing mice. J Transl Med 6:26
    • (2008) J Transl Med , vol.6 , pp. 26
    • Basile, L.A.1    Gallaher, T.K.2    Shibata, D.3    Miller, J.D.4    Douer, D.5
  • 57
    • 0030028620 scopus 로고    scopus 로고
    • In vivo studies with interleukin-12 alone and in combination with monocyte colony-stimulating factor and/or fractionated radiation treatment
    • 8543401
    • Teicher BA, Ara G, Menon K, Schaub RG (1996) In vivo studies with interleukin-12 alone and in combination with monocyte colony-stimulating factor and/or fractionated radiation treatment. Int J Cancer 65:80-84
    • (1996) Int J Cancer , vol.65 , pp. 80-84
    • Teicher, B.A.1    Ara, G.2    Menon, K.3    Schaub, R.G.4
  • 58
    • 12444252093 scopus 로고    scopus 로고
    • Interleukin 12-based immunotherapy improves the antitumor effectiveness of a low-dose 5-Aza-2′-deoxycitidine treatment in L1210 leukemia and B16F10 melanoma models in mice
    • 12912964
    • Kozar K, Kaminski R, Switaj T et al (2003) Interleukin 12-based immunotherapy improves the antitumor effectiveness of a low-dose 5-Aza-2′-deoxycitidine treatment in L1210 leukemia and B16F10 melanoma models in mice. Clin Cancer Res 9:3124-3133
    • (2003) Clin Cancer Res , vol.9 , pp. 3124-3133
    • Kozar, K.1    Kaminski, R.2    Switaj, T.3
  • 59
    • 84877267246 scopus 로고    scopus 로고
    • Enhanced antitumor response mediated by the codelivery of paclitaxel and adenoviral vector expressing IL-12
    • 23534449
    • Cao L, Zeng Q, Xu C, Shi S, Zhang Z, Sun X (2013) Enhanced antitumor response mediated by the codelivery of paclitaxel and adenoviral vector expressing IL-12. Mol Pharm 10:1804-1814
    • (2013) Mol Pharm , vol.10 , pp. 1804-1814
    • Cao, L.1    Zeng, Q.2    Xu, C.3    Shi, S.4    Zhang, Z.5    Sun, X.6
  • 60
    • 0030795160 scopus 로고    scopus 로고
    • Optimal scheduling of interleukin 12 and chemotherapy in the murine MB-49 bladder carcinoma and B16 melanoma
    • 9815857
    • Teicher BA, Ara G, Buxton D, Leonard J, Schaub RG (1997) Optimal scheduling of interleukin 12 and chemotherapy in the murine MB-49 bladder carcinoma and B16 melanoma. Clin Cancer Res 3:1661-1667
    • (1997) Clin Cancer Res , vol.3 , pp. 1661-1667
    • Teicher, B.A.1    Ara, G.2    Buxton, D.3    Leonard, J.4    Schaub, R.G.5
  • 61
    • 0033257934 scopus 로고    scopus 로고
    • Potentiation of antitumor effects of IL-12 in combination with paclitaxel in murine melanoma model in vivo
    • 10567677
    • Zagozdzon R, Golab J, Mucha K, Foroncewicz B, Jakobisiak M (1999) Potentiation of antitumor effects of IL-12 in combination with paclitaxel in murine melanoma model in vivo. Int J Mol Med 4:645-648
    • (1999) Int J Mol Med , vol.4 , pp. 645-648
    • Zagozdzon, R.1    Golab, J.2    Mucha, K.3    Foroncewicz, B.4    Jakobisiak, M.5
  • 62
    • 0035065930 scopus 로고    scopus 로고
    • Potentiated antitumor effectiveness of combined chemo-immunotherapy with interleukin-12 and 5-fluorouracil of L1210 leukemia in vivo
    • Golab J, Zagozdzon R, Kaminski R et al (2001) Potentiated antitumor effectiveness of combined chemo-immunotherapy with interleukin-12 and 5-fluorouracil of L1210 leukemia in vivo. Leukemia 15:613-620
    • (2001) Leukemia , vol.15 , pp. 613-620
    • Golab, J.1    Zagozdzon, R.2    Kaminski, R.3
  • 63
    • 84886631100 scopus 로고    scopus 로고
    • Intra-arterial interleukin-12 gene delivery combined with chemoembolization: Anti-tumor effect in a rabbit hepatocellular carcinoma (HCC) model
    • Xia X, Li X, Feng G, Zheng C, Liang H, Zhou G (2013) Intra-arterial interleukin-12 gene delivery combined with chemoembolization: anti-tumor effect in a rabbit hepatocellular carcinoma (HCC) model. Acta Radiol
    • (2013) Acta Radiol
    • Xia, X.1    Li, X.2    Feng, G.3    Zheng, C.4    Liang, H.5    Zhou, G.6
  • 64
    • 0033631317 scopus 로고    scopus 로고
    • Potentiated anti-tumor effectiveness of combined therapy with interleukin-12 and mitoxantrone of L1210 leukemia in vivo
    • 10601614
    • Golab J, Zagozdzon R, Kozar K, Kaminski R, Giermasz A, Stoklosa T, Lasek W, Jakobisiak M (2000) Potentiated anti-tumor effectiveness of combined therapy with interleukin-12 and mitoxantrone of L1210 leukemia in vivo. Oncol Rep 7:177-181
    • (2000) Oncol Rep , vol.7 , pp. 177-181
    • Golab, J.1    Zagozdzon, R.2    Kozar, K.3    Kaminski, R.4    Giermasz, A.5    Stoklosa, T.6    Lasek, W.7    Jakobisiak, M.8
  • 65
    • 2642620202 scopus 로고    scopus 로고
    • Effective chemo-immunotherapy of L1210 leukemia in vivo using interleukin-12 combined with doxorubicin but not with cyclophosphamide, paclitaxel or cisplatin
    • 9688305
    • Zagozdzon R, Golab J, Stoklosa T, Giermasz A, Nowicka D, Feleszko W, Lasek W, Jakobisiak M (1998) Effective chemo-immunotherapy of L1210 leukemia in vivo using interleukin-12 combined with doxorubicin but not with cyclophosphamide, paclitaxel or cisplatin. Int J Cancer 77:720-727
    • (1998) Int J Cancer , vol.77 , pp. 720-727
    • Zagozdzon, R.1    Golab, J.2    Stoklosa, T.3    Giermasz, A.4    Nowicka, D.5    Feleszko, W.6    Lasek, W.7    Jakobisiak, M.8
  • 66
    • 0035863738 scopus 로고    scopus 로고
    • Complete regression of established spontaneous mammary carcinoma and the therapeutic prevention of genetically programmed neoplastic transition by IL-12/pulse IL-2: Induction of local T cell infiltration, Fas/Fas ligand gene expression, and mammary epithelial apoptosis
    • 11145697
    • Wigginton JM, Park JW, Gruys ME et al (2001) Complete regression of established spontaneous mammary carcinoma and the therapeutic prevention of genetically programmed neoplastic transition by IL-12/pulse IL-2: induction of local T cell infiltration, Fas/Fas ligand gene expression, and mammary epithelial apoptosis. J Immunol 166:1156-1168
    • (2001) J Immunol , vol.166 , pp. 1156-1168
    • Wigginton, J.M.1    Park, J.W.2    Gruys, M.E.3
  • 67
    • 0033019078 scopus 로고    scopus 로고
    • Potent antitumor effects mediated by local expression of the mature form of the interferon-gamma inducing factor, interleukin-18 (IL-18)
    • 10505105
    • Osaki T, Hashimoto W, Gambotto A, Okamura H, Robbins PD, Kurimoto M, Lotze MT, Tahara H (1999) Potent antitumor effects mediated by local expression of the mature form of the interferon-gamma inducing factor, interleukin-18 (IL-18). Gene Ther 6:808-815
    • (1999) Gene Ther , vol.6 , pp. 808-815
    • Osaki, T.1    Hashimoto, W.2    Gambotto, A.3    Okamura, H.4    Robbins, P.D.5    Kurimoto, M.6    Lotze, M.T.7    Tahara, H.8
  • 68
    • 0035209760 scopus 로고    scopus 로고
    • Potentiated antitumor effects of interleukin 12 and interferon alpha against B16F10 melanoma in mice
    • 11845979
    • Dabrowska A, Giermasz A, Golab J, Jakobisiak M (2001) Potentiated antitumor effects of interleukin 12 and interferon alpha against B16F10 melanoma in mice. Neoplasma 48:358-361
    • (2001) Neoplasma , vol.48 , pp. 358-361
    • Dabrowska, A.1    Giermasz, A.2    Golab, J.3    Jakobisiak, M.4
  • 69
    • 2942555182 scopus 로고    scopus 로고
    • IL-12 pretreatments enhance IFN-alpha-induced Janus kinase-STAT signaling and potentiate the antitumor effects of IFN-alpha in a murine model of malignant melanoma
    • 15187113
    • Lesinski GBB, Zimmerer J, Crespin T, Hu Y, Abood G, Carson WE III (2004) IL-12 pretreatments enhance IFN-alpha-induced Janus kinase-STAT signaling and potentiate the antitumor effects of IFN-alpha in a murine model of malignant melanoma. J Immunol 172:7368-7376
    • (2004) J Immunol , vol.172 , pp. 7368-7376
    • Lesinski, G.B.B.1    Zimmerer, J.2    Crespin, T.3    Hu, Y.4    Abood, G.5    Carson III, W.E.6
  • 70
    • 0034284301 scopus 로고    scopus 로고
    • Effective targeting of tumor vasculature by the angiogenesis inhibitors vasostatin and interleukin-12
    • 10961892
    • Yao L, Pike SE, Setsuda J, Parekh J, Gupta G, Raffeld M, Jaffe ES, Tosato G (2000) Effective targeting of tumor vasculature by the angiogenesis inhibitors vasostatin and interleukin-12. Blood 96:1900-1905
    • (2000) Blood , vol.96 , pp. 1900-1905
    • Yao, L.1    Pike, S.E.2    Setsuda, J.3    Parekh, J.4    Gupta, G.5    Raffeld, M.6    Jaffe, E.S.7    Tosato, G.8
  • 71
    • 0031923243 scopus 로고    scopus 로고
    • Optimal scheduling of interleukin-12 and fractionated radiation therapy in the murine Lewis lung carcinoma
    • 9572683
    • Teicher BA, Ara G, Buxton D, Leonard J, Schaub RG (1998) Optimal scheduling of interleukin-12 and fractionated radiation therapy in the murine Lewis lung carcinoma. Radiat Oncol Investig 6:71-80
    • (1998) Radiat Oncol Investig , vol.6 , pp. 71-80
    • Teicher, B.A.1    Ara, G.2    Buxton, D.3    Leonard, J.4    Schaub, R.G.5
  • 72
    • 77955509674 scopus 로고    scopus 로고
    • IL-12 enhances efficacy and shortens enrichment time in cytokine-induced killer cell immunotherapy
    • 20532883
    • Helms MW, Prescher JA, Cao YA, Schaffert S, Contag CH (2010) IL-12 enhances efficacy and shortens enrichment time in cytokine-induced killer cell immunotherapy. Cancer Immunol Immunother 59:1325-1334
    • (2010) Cancer Immunol Immunother , vol.59 , pp. 1325-1334
    • Helms, M.W.1    Prescher, J.A.2    Cao, Y.A.3    Schaffert, S.4    Contag, C.H.5
  • 73
    • 84872788695 scopus 로고    scopus 로고
    • Synergistic antitumor effect of JAWSII dendritic cells and interleukin 12 in a melanoma mouse model
    • 23254470
    • Zapala L, Wolny R, Wachowska M, Jakobisiak M, Lasek W (2013) Synergistic antitumor effect of JAWSII dendritic cells and interleukin 12 in a melanoma mouse model. Oncol Rep 29:1208-1214
    • (2013) Oncol Rep , vol.29 , pp. 1208-1214
    • Zapala, L.1    Wolny, R.2    Wachowska, M.3    Jakobisiak, M.4    Lasek, W.5
  • 74
    • 0035887149 scopus 로고    scopus 로고
    • Administration of interleukin-12 enhances the therapeutic efficacy of dendritic cell-based tumor vaccines in mouse hepatocellular carcinoma
    • 11606395
    • Tatsumi T, Takehara T, Kanto T et al (2001) Administration of interleukin-12 enhances the therapeutic efficacy of dendritic cell-based tumor vaccines in mouse hepatocellular carcinoma. Cancer Res 61:7563-7567
    • (2001) Cancer Res , vol.61 , pp. 7563-7567
    • Tatsumi, T.1    Takehara, T.2    Kanto, T.3
  • 76
    • 0032911087 scopus 로고    scopus 로고
    • Anti-tumor activity of interleukin-2-producing tumor cells and recombinant interleukin 12 against mouse glioma cells located in the central nervous system
    • 9935185
    • Kikuchi T, Joki T, Saitoh S, Hata Y, Abe T, Kato N, Kobayashi A, Miyazaki T, Ohno T (1999) Anti-tumor activity of interleukin-2-producing tumor cells and recombinant interleukin 12 against mouse glioma cells located in the central nervous system. Int J Cancer 80:425-430
    • (1999) Int J Cancer , vol.80 , pp. 425-430
    • Kikuchi, T.1    Joki, T.2    Saitoh, S.3    Hata, Y.4    Abe, T.5    Kato, N.6    Kobayashi, A.7    Miyazaki, T.8    Ohno, T.9
  • 77
    • 0028944328 scopus 로고
    • Influence of interleukin 12 on p53 peptide vaccination against established Meth A sarcoma
    • 42455 7892250
    • Noguchi Y, Richards EC, Chen YT, Old LJ (1995) Influence of interleukin 12 on p53 peptide vaccination against established Meth A sarcoma. Proc Natl Acad Sci USA 92:2219-2223
    • (1995) Proc Natl Acad Sci USA , vol.92 , pp. 2219-2223
    • Noguchi, Y.1    Richards, E.C.2    Chen, Y.T.3    Old, L.J.4
  • 78
    • 79953832076 scopus 로고    scopus 로고
    • Mechanism of synergistic effect of chemotherapy and immunotherapy of cancer
    • 20976448
    • Ramakrishnan R, Gabrilovich DI (2011) Mechanism of synergistic effect of chemotherapy and immunotherapy of cancer. Cancer Immunol Immunother 60:419-423
    • (2011) Cancer Immunol Immunother , vol.60 , pp. 419-423
    • Ramakrishnan, R.1    Gabrilovich, D.I.2
  • 79
    • 84875600868 scopus 로고    scopus 로고
    • Immunomodulatory effects of low dose chemotherapy and perspectives of its combination with immunotherapy
    • 22927096
    • Nars MS, Kaneno R (2013) Immunomodulatory effects of low dose chemotherapy and perspectives of its combination with immunotherapy. Int J Cancer 132:2471-2478
    • (2013) Int J Cancer , vol.132 , pp. 2471-2478
    • Nars, M.S.1    Kaneno, R.2
  • 80
    • 68349123372 scopus 로고    scopus 로고
    • Chemotherapeutic agents in noncytotoxic concentrations increase antigen presentation by dendritic cells via an IL-12-dependent mechanism
    • 19535620
    • Shurin GV, Tourkova IL, Kaneno R, Shurin MR (2009) Chemotherapeutic agents in noncytotoxic concentrations increase antigen presentation by dendritic cells via an IL-12-dependent mechanism. J Immunol 183:137-144
    • (2009) J Immunol , vol.183 , pp. 137-144
    • Shurin, G.V.1    Tourkova, I.L.2    Kaneno, R.3    Shurin, M.R.4
  • 82
    • 34948820602 scopus 로고    scopus 로고
    • Toll-like receptor 4-dependent contribution of the immune system to anticancer chemotherapy and radiotherapy
    • 17704786
    • Apetoh L, Ghiringhelli F, Tesniere A et al (2007) Toll-like receptor 4-dependent contribution of the immune system to anticancer chemotherapy and radiotherapy. Nat Med 13:1050-1059
    • (2007) Nat Med , vol.13 , pp. 1050-1059
    • Apetoh, L.1    Ghiringhelli, F.2    Tesniere, A.3
  • 83
    • 84863145540 scopus 로고    scopus 로고
    • HemaMax, a recombinant human interleukin-12, is a potent mitigator of acute radiation injury in mice and non-human primates
    • 3286478 22383962
    • Basile LA, Ellefson D, Gluzman-Poltorak Z et al (2012) HemaMax, a recombinant human interleukin-12, is a potent mitigator of acute radiation injury in mice and non-human primates. PLoS ONE 7:e30434
    • (2012) PLoS ONE , vol.7 , pp. 30434
    • Basile, L.A.1    Ellefson, D.2    Gluzman-Poltorak, Z.3
  • 87
    • 0028916621 scopus 로고
    • The stimulatory effects of interleukin (IL)-12 on hematopoiesis are antagonized by IL-12-induced interferon gamma in vivo
    • 7722464
    • Eng VM, Car BD, Schnyder B, Lorenz M, Lugli S, Aguet M, Anderson TD, Ryffel B, Quesniaux VF (1995) The stimulatory effects of interleukin (IL)-12 on hematopoiesis are antagonized by IL-12-induced interferon gamma in vivo. J Exp Med 181:1893-1898
    • (1995) J Exp Med , vol.181 , pp. 1893-1898
    • Eng, V.M.1    Car, B.D.2    Schnyder, B.3    Lorenz, M.4    Lugli, S.5    Aguet, M.6    Anderson, T.D.7    Ryffel, B.8    Quesniaux, V.F.9
  • 90
    • 84874868120 scopus 로고    scopus 로고
    • Eradication of liver-implanted tumors by Semliki Forest virus expressing IL-12 requires efficient long-term immune responses
    • 23401594
    • Quetglas JI, Rodriguez-Madoz JR, Bezunartea J et al (2013) Eradication of liver-implanted tumors by Semliki Forest virus expressing IL-12 requires efficient long-term immune responses. J Immunol 190:2994-3004
    • (2013) J Immunol , vol.190 , pp. 2994-3004
    • Quetglas, J.I.1    Rodriguez-Madoz, J.R.2    Bezunartea, J.3
  • 92
    • 0036594813 scopus 로고    scopus 로고
    • IL-12 plasmid delivery by in vivo electroporation for the successful treatment of established subcutaneous B16.F10 melanoma
    • 12027550
    • Lucas ML, Heller L, Coppola D, Heller R (2002) IL-12 plasmid delivery by in vivo electroporation for the successful treatment of established subcutaneous B16.F10 melanoma. Mol Ther 5:668-675
    • (2002) Mol Ther , vol.5 , pp. 668-675
    • Lucas, M.L.1    Heller, L.2    Coppola, D.3    Heller, R.4
  • 93
    • 0033052989 scopus 로고    scopus 로고
    • Intratumoral delivery of IL-12 gene by polyvinyl polymeric vector system to murine renal and colon carcinoma results in potent antitumor immunity
    • 10505108
    • Mendiratta SK, Quezada A, Matar M, Wang J, Hebel HL, Long S, Nordstrom JL, Pericle F (1999) Intratumoral delivery of IL-12 gene by polyvinyl polymeric vector system to murine renal and colon carcinoma results in potent antitumor immunity. Gene Ther 6:833-839
    • (1999) Gene Ther , vol.6 , pp. 833-839
    • Mendiratta, S.K.1    Quezada, A.2    Matar, M.3    Wang, J.4    Hebel, H.L.5    Long, S.6    Nordstrom, J.L.7    Pericle, F.8
  • 94
    • 0034465697 scopus 로고    scopus 로고
    • Tumor regression induced by intratumoral injection of DNA coding for human interleukin 12 into melanoma metastases in gray horses
    • Heinzerling LM, Feige K, Rieder S, Akens MK, Dummer R, Stranzinger G, Moelling K (2001) Tumor regression induced by intratumoral injection of DNA coding for human interleukin 12 into melanoma metastases in gray horses. J Mol Med (Berl) 78:692-702
    • (2001) J Mol Med (Berl) , vol.78 , pp. 692-702
    • Heinzerling, L.M.1    Feige, K.2    Rieder, S.3    Akens, M.K.4    Dummer, R.5    Stranzinger, G.6    Moelling, K.7
  • 96
    • 0032996037 scopus 로고    scopus 로고
    • Adenovirus-mediated interleukin-12 gene therapy for prostate cancer: Suppression of orthotopic tumor growth and pre-established lung metastases in an orthotopic model
    • 10435084
    • Nasu Y, Bangma CH, Hull GW et al (1999) Adenovirus-mediated interleukin-12 gene therapy for prostate cancer: suppression of orthotopic tumor growth and pre-established lung metastases in an orthotopic model. Gene Ther 6:338-349
    • (1999) Gene Ther , vol.6 , pp. 338-349
    • Nasu, Y.1    Bangma, C.H.2    Hull, G.W.3
  • 97
    • 0029148905 scopus 로고
    • Cancer immunotherapy of established tumors with IL-12. Effective delivery by genetically engineered fibroblasts
    • 7636204
    • Zitvogel L, Tahara H, Robbins PD, Storkus WJ, Clarke MR, Nalesnik MA, Lotze MT (1995) Cancer immunotherapy of established tumors with IL-12. Effective delivery by genetically engineered fibroblasts. J Immunol 155:1393-1403
    • (1995) J Immunol , vol.155 , pp. 1393-1403
    • Zitvogel, L.1    Tahara, H.2    Robbins, P.D.3    Storkus, W.J.4    Clarke, M.R.5    Nalesnik, M.A.6    Lotze, M.T.7
  • 98
    • 0033780172 scopus 로고    scopus 로고
    • IL-12 plasmid-enhanced DNA vaccination against carcinoembryonic antigen (CEA) studied in immune-gene knockout mice
    • 11021590
    • Song K, Chang Y, Prud'homme GJ (2000) IL-12 plasmid-enhanced DNA vaccination against carcinoembryonic antigen (CEA) studied in immune-gene knockout mice. Gene Ther 7:1527-1535
    • (2000) Gene Ther , vol.7 , pp. 1527-1535
    • Song, K.1    Chang, Y.2    Prud'Homme, G.J.3
  • 99
    • 0030589377 scopus 로고    scopus 로고
    • Immunotherapy of experimental metastases by vaccination with interleukin gene-transduced adenocarcinoma cells sharing tumor-associated antigens. Comparison between IL-12 and IL-2 gene-transduced tumor cell vaccines
    • 8955204
    • Rodolfo M, Zilocchi C, Melani C, Cappetti B, Arioli I, Parmiani G, Colombo MP (1996) Immunotherapy of experimental metastases by vaccination with interleukin gene-transduced adenocarcinoma cells sharing tumor-associated antigens. Comparison between IL-12 and IL-2 gene-transduced tumor cell vaccines. J Immunol 157:5536-5542
    • (1996) J Immunol , vol.157 , pp. 5536-5542
    • Rodolfo, M.1    Zilocchi, C.2    Melani, C.3    Cappetti, B.4    Arioli, I.5    Parmiani, G.6    Colombo, M.P.7
  • 100
    • 0034895257 scopus 로고    scopus 로고
    • Interleukin-12 gene therapy vaccines: Directing the immune system against minimal residual leukemia
    • 11378566
    • Dunussi-Joannopoulos K, Leonard JP (2001) Interleukin-12 gene therapy vaccines: directing the immune system against minimal residual leukemia. Leuk Lymphoma 41:483-492
    • (2001) Leuk Lymphoma , vol.41 , pp. 483-492
    • Dunussi-Joannopoulos, K.1    Leonard, J.P.2
  • 101
    • 84862489428 scopus 로고    scopus 로고
    • Therapeutic effect of intratumoral administration of DCs with conditional expression of combination of different cytokines
    • 22223258
    • Huang C, Ramakrishnan R, Trkulja M, Ren X, Gabrilovich DI (2012) Therapeutic effect of intratumoral administration of DCs with conditional expression of combination of different cytokines. Cancer Immunol Immunother 61:573-579
    • (2012) Cancer Immunol Immunother , vol.61 , pp. 573-579
    • Huang, C.1    Ramakrishnan, R.2    Trkulja, M.3    Ren, X.4    Gabrilovich, D.I.5
  • 103
    • 0035085327 scopus 로고    scopus 로고
    • Induction of ErbB-2/neu-specific protective and therapeutic antitumor immunity using genetically modified dendritic cells: Enhanced efficacy by cotransduction of gene encoding IL-12
    • 11313806
    • Chen Y, Emtage P, Zhu Q, Foley R, Muller W, Hitt M, Gauldie J, Wan Y (2001) Induction of ErbB-2/neu-specific protective and therapeutic antitumor immunity using genetically modified dendritic cells: enhanced efficacy by cotransduction of gene encoding IL-12. Gene Ther 8:316-323
    • (2001) Gene Ther , vol.8 , pp. 316-323
    • Chen, Y.1    Emtage, P.2    Zhu, Q.3    Foley, R.4    Muller, W.5    Hitt, M.6    Gauldie, J.7    Wan, Y.8
  • 104
    • 84858759305 scopus 로고    scopus 로고
    • Tumor-targeted T cells modified to secrete IL-12 eradicate systemic tumors without need for prior conditioning
    • 3359735 22354001
    • Pegram HJ, Lee JC, Hayman EG, Imperato GH, Tedder TF, Sadelain M, Brentjens RJ (2012) Tumor-targeted T cells modified to secrete IL-12 eradicate systemic tumors without need for prior conditioning. Blood 119:4133-4141
    • (2012) Blood , vol.119 , pp. 4133-4141
    • Pegram, H.J.1    Lee, J.C.2    Hayman, E.G.3    Imperato, G.H.4    Tedder, T.F.5    Sadelain, M.6    Brentjens, R.J.7
  • 105
    • 84887249684 scopus 로고    scopus 로고
    • Preclinical evaluation of oncolytic deltagamma(1)34.5 herpes simplex virus expressing interleukin-12 for therapy of breast cancer brain metastases
    • Cody JJ, Scaturro P, Cantor AB, Yancey Gillespie G, Parker JN, Markert JM (2012) Preclinical evaluation of oncolytic deltagamma(1)34.5 herpes simplex virus expressing interleukin-12 for therapy of breast cancer brain metastases. Int J Breast Cancer 2012:628697
    • (2012) Int J Breast Cancer , pp. 628697
    • Cody, J.J.1    Scaturro, P.2    Cantor, A.B.3    Yancey Gillespie, G.4    Parker, J.N.5    Markert, J.M.6
  • 106
    • 77953704558 scopus 로고    scopus 로고
    • Enhanced growth inhibition of metastatic lung tumors by intravenous injection of ATRA-cationic liposome/IL-12 pDNA complexes in mice
    • 20414324
    • Charoensit P, Kawakami S, Higuchi Y, Yamashita F, Hashida M (2010) Enhanced growth inhibition of metastatic lung tumors by intravenous injection of ATRA-cationic liposome/IL-12 pDNA complexes in mice. Cancer Gene Ther 17:512-522
    • (2010) Cancer Gene Ther , vol.17 , pp. 512-522
    • Charoensit, P.1    Kawakami, S.2    Higuchi, Y.3    Yamashita, F.4    Hashida, M.5
  • 107
    • 0035757052 scopus 로고    scopus 로고
    • Combined delivery of an antiangiogenic protein (angiostatin) and an immunomodulatory gene (interleukin-12) in the treatment of murine cancer
    • 11995969
    • Wilczynska U, Kucharska A, Szary J, Szala S (2001) Combined delivery of an antiangiogenic protein (angiostatin) and an immunomodulatory gene (interleukin-12) in the treatment of murine cancer. Acta Biochim Pol 48:1077-1084
    • (2001) Acta Biochim Pol , vol.48 , pp. 1077-1084
    • Wilczynska, U.1    Kucharska, A.2    Szary, J.3    Szala, S.4
  • 108
    • 0031759989 scopus 로고    scopus 로고
    • Intratumoral coinjection of adenoviral vectors expressing IL-2 and IL-12 results in enhanced frequency of regression of injected and untreated distal tumors
    • 9930346
    • Addison CL, Bramson JL, Hitt MM, Muller WJ, Gauldie J, Graham FL (1998) Intratumoral coinjection of adenoviral vectors expressing IL-2 and IL-12 results in enhanced frequency of regression of injected and untreated distal tumors. Gene Ther 5:1400-1409
    • (1998) Gene Ther , vol.5 , pp. 1400-1409
    • Addison, C.L.1    Bramson, J.L.2    Hitt, M.M.3    Muller, W.J.4    Gauldie, J.5    Graham, F.L.6
  • 109
    • 0032521153 scopus 로고    scopus 로고
    • Interleukin-12 and interleukin-18 synergistically induce murine tumor regression which involves inhibition of angiogenesis
    • 508700 9502787
    • Coughlin CM, Salhany KE, Wysocka M et al (1998) Interleukin-12 and interleukin-18 synergistically induce murine tumor regression which involves inhibition of angiogenesis. J Clin Invest 101:1441-1452
    • (1998) J Clin Invest , vol.101 , pp. 1441-1452
    • Coughlin, C.M.1    Salhany, K.E.2    Wysocka, M.3
  • 110
    • 77951923924 scopus 로고    scopus 로고
    • IL-12 and IL-27 sequential gene therapy via intramuscular electroporation delivery for eliminating distal aggressive tumors
    • 2824785 20139275
    • Zhu S, Lee DA, Li S (2010) IL-12 and IL-27 sequential gene therapy via intramuscular electroporation delivery for eliminating distal aggressive tumors. J Immunol 184:2348-2354
    • (2010) J Immunol , vol.184 , pp. 2348-2354
    • Zhu, S.1    Lee, D.A.2    Li, S.3
  • 111
    • 0035085442 scopus 로고    scopus 로고
    • Combined CXC chemokine and interleukin-12 gene transfer enhances antitumor immunity
    • 11313802
    • Palmer K, Hitt M, Emtage PC, Gyorffy S, Gauldie J (2001) Combined CXC chemokine and interleukin-12 gene transfer enhances antitumor immunity. Gene Ther 8:282-290
    • (2001) Gene Ther , vol.8 , pp. 282-290
    • Palmer, K.1    Hitt, M.2    Emtage, P.C.3    Gyorffy, S.4    Gauldie, J.5
  • 112
    • 0033586324 scopus 로고    scopus 로고
    • Adenoviral vectors expressing lymphotactin and interleukin 2 or lymphotactin and interleukin 12 synergize to facilitate tumor regression in murine breast cancer models
    • 10210138
    • Emtage PC, Wan Y, Hitt M, Graham FL, Muller WJ, Zlotnik A, Gauldie J (1999) Adenoviral vectors expressing lymphotactin and interleukin 2 or lymphotactin and interleukin 12 synergize to facilitate tumor regression in murine breast cancer models. Hum Gene Ther 10:697-709
    • (1999) Hum Gene Ther , vol.10 , pp. 697-709
    • Emtage, P.C.1    Wan, Y.2    Hitt, M.3    Graham, F.L.4    Muller, W.J.5    Zlotnik, A.6    Gauldie, J.7
  • 113
    • 0030931602 scopus 로고    scopus 로고
    • Interleukin 12 and B7-1 costimulatory molecule expressed by an adenovirus vector act synergistically to facilitate tumor regression
    • 23520 9380730
    • Putzer BM, Hitt M, Muller WJ, Emtage P, Gauldie J, Graham FL (1997) Interleukin 12 and B7-1 costimulatory molecule expressed by an adenovirus vector act synergistically to facilitate tumor regression. Proc Natl Acad Sci USA 94:10889-10894
    • (1997) Proc Natl Acad Sci USA , vol.94 , pp. 10889-10894
    • Putzer, B.M.1    Hitt, M.2    Muller, W.J.3    Emtage, P.4    Gauldie, J.5    Graham, F.L.6
  • 114
    • 84867052405 scopus 로고    scopus 로고
    • Immunotherapeutic synergy between anti-CD137 mAb and intratumoral administration of a cytopathic Semliki Forest virus encoding IL-12
    • 3437571 22735380
    • Quetglas JI, Dubrot J, Bezunartea J, Sanmamed MF, Hervas-Stubbs S, Smerdou C, Melero I (2012) Immunotherapeutic synergy between anti-CD137 mAb and intratumoral administration of a cytopathic Semliki Forest virus encoding IL-12. Mol Ther 20:1664-1675
    • (2012) Mol Ther , vol.20 , pp. 1664-1675
    • Quetglas, J.I.1    Dubrot, J.2    Bezunartea, J.3    Sanmamed, M.F.4    Hervas-Stubbs, S.5    Smerdou, C.6    Melero, I.7
  • 115
    • 0034616629 scopus 로고    scopus 로고
    • Immunomodulatory gene therapy with interleukin 12 and 4-1BB ligand: Long-term remission of liver metastases in a mouse model
    • 10841829
    • Martinet O, Ermekova V, Qiao JQ, Sauter B, Mandeli J, Chen L, Chen SH (2000) Immunomodulatory gene therapy with interleukin 12 and 4-1BB ligand: long-term remission of liver metastases in a mouse model. J Natl Cancer Inst 92:931-936
    • (2000) J Natl Cancer Inst , vol.92 , pp. 931-936
    • Martinet, O.1    Ermekova, V.2    Qiao, J.Q.3    Sauter, B.4    Mandeli, J.5    Chen, L.6    Chen, S.H.7
  • 116
    • 3042628507 scopus 로고    scopus 로고
    • CpG immunostimulatory oligodeoxynucleotide 1826 enhances antitumor effect of interleukin 12 gene-modified tumor vaccine in a melanoma model in mice
    • 15217954
    • Switaj T, Jalili A, Jakubowska AB et al (2004) CpG immunostimulatory oligodeoxynucleotide 1826 enhances antitumor effect of interleukin 12 gene-modified tumor vaccine in a melanoma model in mice. Clin Cancer Res 10:4165-4175
    • (2004) Clin Cancer Res , vol.10 , pp. 4165-4175
    • Switaj, T.1    Jalili, A.2    Jakubowska, A.B.3
  • 117
    • 0029868353 scopus 로고    scopus 로고
    • IL-12: A key cytokine in immune regulation
    • 8991382
    • Lamont AG, Adorini L (1996) IL-12: a key cytokine in immune regulation. Immunol Today 17:214-217
    • (1996) Immunol Today , vol.17 , pp. 214-217
    • Lamont, A.G.1    Adorini, L.2
  • 118
    • 0030005001 scopus 로고    scopus 로고
    • After initial setback, IL-12 regaining popularity
    • 8609654
    • Jenks S (1996) After initial setback, IL-12 regaining popularity. J Natl Cancer Inst 88:576-577
    • (1996) J Natl Cancer Inst , vol.88 , pp. 576-577
    • Jenks, S.1
  • 119
    • 0030766971 scopus 로고    scopus 로고
    • Effects of single-dose interleukin-12 exposure on interleukin-12- associated toxicity and interferon-gamma production
    • 9326219
    • Leonard JP, Sherman ML, Fisher GL et al (1997) Effects of single-dose interleukin-12 exposure on interleukin-12-associated toxicity and interferon-gamma production. Blood 90:2541-2548
    • (1997) Blood , vol.90 , pp. 2541-2548
    • Leonard, J.P.1    Sherman, M.L.2    Fisher, G.L.3
  • 120
    • 0028824039 scopus 로고
    • IL-12 deaths: Explanation and a puzzle
    • 7481785
    • Cohen J (1995) IL-12 deaths: explanation and a puzzle. Science 270:908
    • (1995) Science , vol.270 , pp. 908
    • Cohen, J.1
  • 121
    • 0030887047 scopus 로고    scopus 로고
    • Phase i evaluation of intravenous recombinant human interleukin 12 in patients with advanced malignancies
    • 9815699
    • Atkins MB, Robertson MJ, Gordon M et al (1997) Phase I evaluation of intravenous recombinant human interleukin 12 in patients with advanced malignancies. Clin Cancer Res 3:409-417
    • (1997) Clin Cancer Res , vol.3 , pp. 409-417
    • Atkins, M.B.1    Robertson, M.J.2    Gordon, M.3
  • 123
    • 0034103809 scopus 로고    scopus 로고
    • Phase i trial of twice-weekly intravenous interleukin 12 in patients with metastatic renal cell cancer or malignant melanoma: Ability to maintain IFN-gamma induction is associated with clinical response
    • 10815886
    • Gollob JA, Mier JW, Veenstra K, McDermott DF, Clancy D, Clancy M, Atkins MB (2000) Phase I trial of twice-weekly intravenous interleukin 12 in patients with metastatic renal cell cancer or malignant melanoma: ability to maintain IFN-gamma induction is associated with clinical response. Clin Cancer Res 6:1678-1692
    • (2000) Clin Cancer Res , vol.6 , pp. 1678-1692
    • Gollob, J.A.1    Mier, J.W.2    Veenstra, K.3    McDermott, D.F.4    Clancy, D.5    Clancy, M.6    Atkins, M.B.7
  • 124
    • 0031929620 scopus 로고    scopus 로고
    • Pilot study of subcutaneous recombinant human interleukin 12 in metastatic melanoma
    • 9516955
    • Bajetta E, Del Vecchio M, Mortarini R et al (1998) Pilot study of subcutaneous recombinant human interleukin 12 in metastatic melanoma. Clin Cancer Res 4:75-85
    • (1998) Clin Cancer Res , vol.4 , pp. 75-85
    • Bajetta, E.1    Del Vecchio, M.2    Mortarini, R.3
  • 126
    • 0036897227 scopus 로고    scopus 로고
    • Phase i study of intraperitoneal recombinant human interleukin 12 in patients with Mullerian carcinoma, gastrointestinal primary malignancies, and mesothelioma
    • 12473577
    • Lenzi R, Rosenblum M, Verschraegen C et al (2002) Phase I study of intraperitoneal recombinant human interleukin 12 in patients with Mullerian carcinoma, gastrointestinal primary malignancies, and mesothelioma. Clin Cancer Res 8:3686-3695
    • (2002) Clin Cancer Res , vol.8 , pp. 3686-3695
    • Lenzi, R.1    Rosenblum, M.2    Verschraegen, C.3
  • 127
    • 1342343087 scopus 로고    scopus 로고
    • A phase II trial of interleukin-12 in patients with advanced cervical cancer: Clinical and immunologic correlates. Eastern Cooperative Oncology Group study E1E96
    • 14984966
    • Wadler S, Levy D, Frederickson HL et al (2004) A phase II trial of interleukin-12 in patients with advanced cervical cancer: clinical and immunologic correlates. Eastern Cooperative Oncology Group study E1E96. Gynecol Oncol 92:957-964
    • (2004) Gynecol Oncol , vol.92 , pp. 957-964
    • Wadler, S.1    Levy, D.2    Frederickson, H.L.3
  • 128
    • 0033973093 scopus 로고    scopus 로고
    • Cytokines and soluble cytokine receptor induction after IL-12 administration in cancer patients
    • 1905550 10606961
    • Haicheur N, Escudier B, Dorval T et al (2000) Cytokines and soluble cytokine receptor induction after IL-12 administration in cancer patients. Clin Exp Immunol 119:28-37
    • (2000) Clin Exp Immunol , vol.119 , pp. 28-37
    • Haicheur, N.1    Escudier, B.2    Dorval, T.3
  • 129
    • 0033388981 scopus 로고    scopus 로고
    • Phase i study of subcutaneously administered recombinant human interleukin 12 in patients with advanced renal cell cancer
    • 10632329
    • Portielje JE, Kruit WH, Schuler M et al (1999) Phase I study of subcutaneously administered recombinant human interleukin 12 in patients with advanced renal cell cancer. Clin Cancer Res 5:3983-3989
    • (1999) Clin Cancer Res , vol.5 , pp. 3983-3989
    • Portielje, J.E.1    Kruit, W.H.2    Schuler, M.3
  • 130
    • 0037242365 scopus 로고    scopus 로고
    • Repeated administrations of interleukin (IL)-12 are associated with persistently elevated plasma levels of IL-10 and declining IFN-gamma, tumor necrosis factor-alpha, IL-6, and IL-8 responses
    • 12538454
    • Portielje JE, Lamers CH, Kruit WH, Sparreboom A, Bolhuis RL, Stoter G, Huber C, Gratama JW (2003) Repeated administrations of interleukin (IL)-12 are associated with persistently elevated plasma levels of IL-10 and declining IFN-gamma, tumor necrosis factor-alpha, IL-6, and IL-8 responses. Clin Cancer Res 9:76-83
    • (2003) Clin Cancer Res , vol.9 , pp. 76-83
    • Portielje, J.E.1    Lamers, C.H.2    Kruit, W.H.3    Sparreboom, A.4    Bolhuis, R.L.5    Stoter, G.6    Huber, C.7    Gratama, J.W.8
  • 131
    • 70949093473 scopus 로고    scopus 로고
    • A phase i trial of paclitaxel and trastuzumab in combination with interleukin-12 in patients with HER2/neu-expressing malignancies
    • 2996611 19887543
    • Bekaii-Saab TS, Roda JM, Guenterberg KD et al (2009) A phase I trial of paclitaxel and trastuzumab in combination with interleukin-12 in patients with HER2/neu-expressing malignancies. Mol Cancer Ther 8:2983-2991
    • (2009) Mol Cancer Ther , vol.8 , pp. 2983-2991
    • Bekaii-Saab, T.S.1    Roda, J.M.2    Guenterberg, K.D.3
  • 134
    • 4143149590 scopus 로고    scopus 로고
    • A phase i study of interleukin 12 with trastuzumab in patients with human epidermal growth factor receptor-2-overexpressing malignancies: Analysis of sustained interferon gamma production in a subset of patients
    • 15297404
    • Parihar R, Nadella P, Lewis A et al (2004) A phase I study of interleukin 12 with trastuzumab in patients with human epidermal growth factor receptor-2-overexpressing malignancies: analysis of sustained interferon gamma production in a subset of patients. Clin Cancer Res 10:5027-5037
    • (2004) Clin Cancer Res , vol.10 , pp. 5027-5037
    • Parihar, R.1    Nadella, P.2    Lewis, A.3
  • 135
    • 33750704288 scopus 로고    scopus 로고
    • Randomized phase II study of interleukin-12 in combination with rituximab in previously treated non-Hodgkin's lymphoma patients
    • 17062681
    • Ansell SM, Geyer SM, Maurer MJ et al (2006) Randomized phase II study of interleukin-12 in combination with rituximab in previously treated non-Hodgkin's lymphoma patients. Clin Cancer Res 12:6056-6063
    • (2006) Clin Cancer Res , vol.12 , pp. 6056-6063
    • Ansell, S.M.1    Geyer, S.M.2    Maurer, M.J.3
  • 136
    • 33846322927 scopus 로고    scopus 로고
    • Alum with interleukin-12 augments immunity to a melanoma peptide vaccine: Correlation with time to relapse in patients with resected high-risk disease
    • 17200357
    • Hamid O, Solomon JC, Scotland R, Garcia M, Sian S, Ye W, Groshen SL, Weber JS (2007) Alum with interleukin-12 augments immunity to a melanoma peptide vaccine: correlation with time to relapse in patients with resected high-risk disease. Clin Cancer Res 13:215-222
    • (2007) Clin Cancer Res , vol.13 , pp. 215-222
    • Hamid, O.1    Solomon, J.C.2    Scotland, R.3    Garcia, M.4    Sian, S.5    Ye, W.6    Groshen, S.L.7    Weber, J.S.8
  • 137
    • 0035884621 scopus 로고    scopus 로고
    • Effects of interleukin-12 on the immune response to a multipeptide vaccine for resected metastatic melanoma
    • 11559721
    • Lee P, Wang F, Kuniyoshi J et al (2001) Effects of interleukin-12 on the immune response to a multipeptide vaccine for resected metastatic melanoma. J Clin Oncol 19:3836-3847
    • (2001) J Clin Oncol , vol.19 , pp. 3836-3847
    • Lee, P.1    Wang, F.2    Kuniyoshi, J.3
  • 138
    • 33947359949 scopus 로고    scopus 로고
    • Long-term idiotype vaccination combined with interleukin-12 (IL-12), or IL-12 and granulocyte macrophage colony-stimulating factor, in early-stage multiple myeloma patients
    • 17332295
    • Hansson L, Abdalla AO, Moshfegh A, Choudhury A, Rabbani H, Nilsson B, Osterborg A, Mellstedt H (2007) Long-term idiotype vaccination combined with interleukin-12 (IL-12), or IL-12 and granulocyte macrophage colony-stimulating factor, in early-stage multiple myeloma patients. Clin Cancer Res 13:1503-1510
    • (2007) Clin Cancer Res , vol.13 , pp. 1503-1510
    • Hansson, L.1    Abdalla, A.O.2    Moshfegh, A.3    Choudhury, A.4    Rabbani, H.5    Nilsson, B.6    Osterborg, A.7    Mellstedt, H.8
  • 139
    • 0037811736 scopus 로고    scopus 로고
    • Immunization with Melan-A peptide-pulsed peripheral blood mononuclear cells plus recombinant human interleukin-12 induces clinical activity and T-cell responses in advanced melanoma
    • 12805336
    • Peterson AC, Harlin H, Gajewski TF (2003) Immunization with Melan-A peptide-pulsed peripheral blood mononuclear cells plus recombinant human interleukin-12 induces clinical activity and T-cell responses in advanced melanoma. J Clin Oncol 21:2342-2348
    • (2003) J Clin Oncol , vol.21 , pp. 2342-2348
    • Peterson, A.C.1    Harlin, H.2    Gajewski, T.F.3
  • 140
    • 39649118243 scopus 로고    scopus 로고
    • Phase 2 study of pegylated liposomal doxorubicin in combination with interleukin-12 for AIDS-related Kaposi sarcoma
    • 2234790 17846226
    • Little RF, Aleman K, Kumar P et al (2007) Phase 2 study of pegylated liposomal doxorubicin in combination with interleukin-12 for AIDS-related Kaposi sarcoma. Blood 110:4165-4171
    • (2007) Blood , vol.110 , pp. 4165-4171
    • Little, R.F.1    Aleman, K.2    Kumar, P.3
  • 141
    • 0038690512 scopus 로고    scopus 로고
    • Phase i trial of concurrent twice-weekly recombinant human interleukin-12 plus low-dose IL-2 in patients with melanoma or renal cell carcinoma
    • 12829677
    • Gollob JA, Veenstra KG, Parker RA, Mier JW, McDermott DF, Clancy D, Tutin L, Koon H, Atkins MB (2003) Phase I trial of concurrent twice-weekly recombinant human interleukin-12 plus low-dose IL-2 in patients with melanoma or renal cell carcinoma. J Clin Oncol 21:2564-2573
    • (2003) J Clin Oncol , vol.21 , pp. 2564-2573
    • Gollob, J.A.1    Veenstra, K.G.2    Parker, R.A.3    Mier, J.W.4    McDermott, D.F.5    Clancy, D.6    Tutin, L.7    Koon, H.8    Atkins, M.B.9
  • 142
    • 33644837418 scopus 로고    scopus 로고
    • Phase i study of the sequential combination of interleukin-12 and interferon alfa-2b in advanced cancer: Evidence for modulation of interferon signaling pathways by interleukin-12
    • 16314644
    • Eisenbeis CF, Lesinski GB, Anghelina M et al (2005) Phase I study of the sequential combination of interleukin-12 and interferon alfa-2b in advanced cancer: evidence for modulation of interferon signaling pathways by interleukin-12. J Clin Oncol 23:8835-8844
    • (2005) J Clin Oncol , vol.23 , pp. 8835-8844
    • Eisenbeis, C.F.1    Lesinski, G.B.2    Anghelina, M.3
  • 143
    • 4344684281 scopus 로고    scopus 로고
    • Clinical and immunologic effects of subcutaneously administered interleukin-12 and interferon alfa-2b: Phase i trial of patients with metastatic renal cell carcinoma or malignant melanoma
    • 15254058
    • Alatrash G, Hutson TE, Molto L et al (2004) Clinical and immunologic effects of subcutaneously administered interleukin-12 and interferon alfa-2b: phase I trial of patients with metastatic renal cell carcinoma or malignant melanoma. J Clin Oncol 22:2891-2900
    • (2004) J Clin Oncol , vol.22 , pp. 2891-2900
    • Alatrash, G.1    Hutson, T.E.2    Molto, L.3
  • 144
    • 0035831628 scopus 로고    scopus 로고
    • Interleukin 12 gene therapy of cancer by peritumoral injection of transduced autologous fibroblasts: Outcome of a phase i study
    • 11426466
    • Kang WK, Park C, Yoon HL et al (2001) Interleukin 12 gene therapy of cancer by peritumoral injection of transduced autologous fibroblasts: outcome of a phase I study. Hum Gene Ther 12:671-684
    • (2001) Hum Gene Ther , vol.12 , pp. 671-684
    • Kang, W.K.1    Park, C.2    Yoon, H.L.3
  • 145
    • 2342570309 scopus 로고    scopus 로고
    • Phase i trial of intratumoral injection of an adenovirus encoding interleukin-12 for advanced digestive tumors
    • 15084613
    • Sangro B, Mazzolini G, Ruiz J et al (2004) Phase I trial of intratumoral injection of an adenovirus encoding interleukin-12 for advanced digestive tumors. J Clin Oncol 22:1389-1397
    • (2004) J Clin Oncol , vol.22 , pp. 1389-1397
    • Sangro, B.1    Mazzolini, G.2    Ruiz, J.3
  • 146
    • 0042679543 scopus 로고    scopus 로고
    • Gene therapy of cancer with interleukin-12
    • 12871184
    • Mazzolini G, Prieto J, Melero I (2003) Gene therapy of cancer with interleukin-12. Curr Pharm Des 9:1981-1991
    • (2003) Curr Pharm des , vol.9 , pp. 1981-1991
    • Mazzolini, G.1    Prieto, J.2    Melero, I.3
  • 147
    • 0031895957 scopus 로고    scopus 로고
    • Vaccination with IL-12 gene-modified autologous melanoma cells: Preclinical results and a first clinical phase i study
    • 9614572
    • Sun Y, Jurgovsky K, Moller P, Alijagic S, Dorbic T, Georgieva J, Wittig B, Schadendorf D (1998) Vaccination with IL-12 gene-modified autologous melanoma cells: preclinical results and a first clinical phase I study. Gene Ther 5:481-490
    • (1998) Gene Ther , vol.5 , pp. 481-490
    • Sun, Y.1    Jurgovsky, K.2    Moller, P.3    Alijagic, S.4    Dorbic, T.5    Georgieva, J.6    Wittig, B.7    Schadendorf, D.8
  • 149
    • 20344403777 scopus 로고    scopus 로고
    • Phase i study of the intratumoral administration of recombinant canarypox viruses expressing B7.1 and interleukin 12 in patients with metastatic melanoma
    • 15930353
    • Triozzi PL, Allen KO, Carlisle RR, Craig M, LoBuglio AF, Conry RM (2005) Phase I study of the intratumoral administration of recombinant canarypox viruses expressing B7.1 and interleukin 12 in patients with metastatic melanoma. Clin Cancer Res 11:4168-4175
    • (2005) Clin Cancer Res , vol.11 , pp. 4168-4175
    • Triozzi, P.L.1    Allen, K.O.2    Carlisle, R.R.3    Craig, M.4    Lobuglio, A.F.5    Conry, R.M.6
  • 150
    • 0028797606 scopus 로고
    • IL-12 reverses cytokine and immune abnormalities in Sezary syndrome
    • 7822812
    • Rook AH, Kubin M, Cassin M et al (1995) IL-12 reverses cytokine and immune abnormalities in Sezary syndrome. J Immunol 154:1491-1498
    • (1995) J Immunol , vol.154 , pp. 1491-1498
    • Rook, A.H.1    Kubin, M.2    Cassin, M.3
  • 151
    • 0033178680 scopus 로고    scopus 로고
    • Interleukin-12 therapy of cutaneous T-cell lymphoma induces lesion regression and cytotoxic T-cell responses
    • 10419880
    • Rook AH, Wood GS, Yoo EK et al (1999) Interleukin-12 therapy of cutaneous T-cell lymphoma induces lesion regression and cytotoxic T-cell responses. Blood 94:902-908
    • (1999) Blood , vol.94 , pp. 902-908
    • Rook, A.H.1    Wood, G.S.2    Yoo, E.K.3
  • 152
    • 33749684290 scopus 로고    scopus 로고
    • A phase II open-label study of recombinant human interleukin-12 in patients with stage IA, IB, or IIA mycosis fungoides
    • 17052486
    • Duvic M, Sherman ML, Wood GS et al (2006) A phase II open-label study of recombinant human interleukin-12 in patients with stage IA, IB, or IIA mycosis fungoides. J Am Acad Dermatol 55:807-813
    • (2006) J Am Acad Dermatol , vol.55 , pp. 807-813
    • Duvic, M.1    Sherman, M.L.2    Wood, G.S.3
  • 153
    • 4143073644 scopus 로고    scopus 로고
    • Phase II clinical trial of interleukin-12 in patients with relapsed and refractory non-Hodgkin's lymphoma and Hodgkin's disease
    • 15328181
    • Younes A, Pro B, Robertson MJ et al (2004) Phase II clinical trial of interleukin-12 in patients with relapsed and refractory non-Hodgkin's lymphoma and Hodgkin's disease. Clin Cancer Res 10:5432-5438
    • (2004) Clin Cancer Res , vol.10 , pp. 5432-5438
    • Younes, A.1    Pro, B.2    Robertson, M.J.3
  • 154
    • 0036090166 scopus 로고    scopus 로고
    • Phase 1 study of interleukin-12 in combination with rituximab in patients with B-cell non-Hodgkin lymphoma
    • 11756154
    • Ansell SM, Witzig TE, Kurtin PJ et al (2002) Phase 1 study of interleukin-12 in combination with rituximab in patients with B-cell non-Hodgkin lymphoma. Blood 99:67-74
    • (2002) Blood , vol.99 , pp. 67-74
    • Ansell, S.M.1    Witzig, T.E.2    Kurtin, P.J.3
  • 155
    • 84868201843 scopus 로고    scopus 로고
    • Management of indolent lymphoma: Where are we now and where are we going
    • 3632507 23063143
    • Lunning MA, Vose JM (2012) Management of indolent lymphoma: where are we now and where are we going. Blood Rev 26:279-288
    • (2012) Blood Rev , vol.26 , pp. 279-288
    • Lunning, M.A.1    Vose, J.M.2
  • 158
    • 84874118594 scopus 로고    scopus 로고
    • Local targets for immune therapy to cancer: Tumor draining lymph nodes and tumor microenvironment
    • 22858832
    • Fransen MF, Arens R, Melief CJ (2013) Local targets for immune therapy to cancer: tumor draining lymph nodes and tumor microenvironment. Int J Cancer 132:1971-1976
    • (2013) Int J Cancer , vol.132 , pp. 1971-1976
    • Fransen, M.F.1    Arens, R.2    Melief, C.J.3
  • 160
    • 41149109074 scopus 로고    scopus 로고
    • Phase II study of intraperitoneal recombinant interleukin-12 (rhIL-12) in patients with peritoneal carcinomatosis (residual disease <1 cm) associated with ovarian cancer or primary peritoneal carcinoma
    • 2248163 18076766
    • Lenzi R, Edwards R, June C, Seiden MV, Garcia ME, Rosenblum M, Freedman RS (2007) Phase II study of intraperitoneal recombinant interleukin-12 (rhIL-12) in patients with peritoneal carcinomatosis (residual disease <1 cm) associated with ovarian cancer or primary peritoneal carcinoma. J Transl Med 5:66
    • (2007) J Transl Med , vol.5 , pp. 66
    • Lenzi, R.1    Edwards, R.2    June, C.3    Seiden, M.V.4    Garcia, M.E.5    Rosenblum, M.6    Freedman, R.S.7
  • 161
    • 77949424738 scopus 로고    scopus 로고
    • Phase-I clinical trial of IL-12 plasmid/lipopolymer complexes for the treatment of recurrent ovarian cancer
    • 20033066
    • Anwer K, Barnes MN, Fewell J, Lewis DH, Alvarez RD (2010) Phase-I clinical trial of IL-12 plasmid/lipopolymer complexes for the treatment of recurrent ovarian cancer. Gene Ther 17:360-369
    • (2010) Gene Ther , vol.17 , pp. 360-369
    • Anwer, K.1    Barnes, M.N.2    Fewell, J.3    Lewis, D.H.4    Alvarez, R.D.5
  • 162
    • 84885321751 scopus 로고    scopus 로고
    • Phase i trial of a formulated IL-12 plasmid in combination with carboplatin and docetaxel chemotherapy in the treatment of platinum-sensitive recurrent ovarian cancer
    • Anwer K, Kelly FJ, Chu C, Fewell JG, Lewis D, Alvarez RD (2013) Phase I trial of a formulated IL-12 plasmid in combination with carboplatin and docetaxel chemotherapy in the treatment of platinum-sensitive recurrent ovarian cancer. Gynecol Oncol 131:169-173
    • (2013) Gynecol Oncol , vol.131 , pp. 169-173
    • Anwer, K.1    Kelly, F.J.2    Chu, C.3    Fewell, J.G.4    Lewis, D.5    Alvarez, R.D.6
  • 165
    • 58049200809 scopus 로고    scopus 로고
    • Phase i trial of interleukin-12 plasmid electroporation in patients with metastatic melanoma
    • 2645111 19029422
    • Daud AI, DeConti RC, Andrews S et al (2008) Phase I trial of interleukin-12 plasmid electroporation in patients with metastatic melanoma. J Clin Oncol 26:5896-5903
    • (2008) J Clin Oncol , vol.26 , pp. 5896-5903
    • Daud, A.I.1    Deconti, R.C.2    Andrews, S.3
  • 167
    • 84858758766 scopus 로고    scopus 로고
    • Adoptive immunotherapy for cancer: Harnessing the T cell response
    • 22437939
    • Restifo NP, Dudley ME, Rosenberg SA (2012) Adoptive immunotherapy for cancer: harnessing the T cell response. Nat Rev Immunol 12:269-281
    • (2012) Nat Rev Immunol , vol.12 , pp. 269-281
    • Restifo, N.P.1    Dudley, M.E.2    Rosenberg, S.A.3
  • 168
    • 84887991307 scopus 로고    scopus 로고
    • Randomized selection design trial evaluating CD8+-enriched versus unselected tumor-infiltrating lymphocytes for adoptive cell therapy for patients with melanoma
    • 23650429
    • Dudley ME, Gross CA, Somerville RP et al (2013) Randomized selection design trial evaluating CD8+-enriched versus unselected tumor-infiltrating lymphocytes for adoptive cell therapy for patients with melanoma. J Clin Oncol 31:2152-2159
    • (2013) J Clin Oncol , vol.31 , pp. 2152-2159
    • Dudley, M.E.1    Gross, C.A.2    Somerville, R.P.3
  • 169
    • 84899896110 scopus 로고    scopus 로고
    • A phase i open-label study of Ad-RTS-hIL-12, an adenoviral vector engineered to express hIL-12 under the control of an oral activator ligand, in subjects with unrespectable stage III/IV melanoma
    • 2013 ASCO Annual Meeting Abstracts, abstr. No. 3022
    • Linette GP, Hamid O, Whitman ED et al (2013) A phase I open-label study of Ad-RTS-hIL-12, an adenoviral vector engineered to express hIL-12 under the control of an oral activator ligand, in subjects with unrespectable stage III/IV melanoma. J Clin Oncol 31(15) SUPPL., 2013 ASCO Annual Meeting Abstracts, abstr. No. 3022
    • (2013) J Clin Oncol , vol.31 , Issue.15 SUPPL.
    • Linette, G.P.1    Hamid, O.2    Whitman, E.D.3
  • 170
    • 84861171729 scopus 로고    scopus 로고
    • Dendritic/tumor fusion cells as cancer vaccines
    • 22595051
    • Avigan D, Rosenblatt J, Kufe D (2012) Dendritic/tumor fusion cells as cancer vaccines. Semin Oncol 39:287-295
    • (2012) Semin Oncol , vol.39 , pp. 287-295
    • Avigan, D.1    Rosenblatt, J.2    Kufe, D.3
  • 171
    • 0034840181 scopus 로고    scopus 로고
    • Results of a phase i clinical trial of vaccination of glioma patients with fusions of dendritic and glioma cells
    • 11676393
    • Kikuchi T, Akasaki Y, Irie M, Homma S, Abe T, Ohno T (2001) Results of a phase I clinical trial of vaccination of glioma patients with fusions of dendritic and glioma cells. Cancer Immunol Immunother 50:337-344
    • (2001) Cancer Immunol Immunother , vol.50 , pp. 337-344
    • Kikuchi, T.1    Akasaki, Y.2    Irie, M.3    Homma, S.4    Abe, T.5    Ohno, T.6
  • 172
    • 34748846272 scopus 로고    scopus 로고
    • Phase I/II study of vaccination with electrofused allogeneic dendritic cells/autologous tumor-derived cells in patients with stage IV renal cell carcinoma
    • 17893567
    • Avigan DE, Vasir B, George DJ et al (2007) Phase I/II study of vaccination with electrofused allogeneic dendritic cells/autologous tumor-derived cells in patients with stage IV renal cell carcinoma. J Immunother 30:749-761
    • (2007) J Immunother , vol.30 , pp. 749-761
    • Avigan, D.E.1    Vasir, B.2    George, D.J.3
  • 173
    • 78751510278 scopus 로고    scopus 로고
    • Vaccination with dendritic cell/tumor fusion cells results in cellular and humoral antitumor immune responses in patients with multiple myeloma
    • 3031474 21030562
    • Rosenblatt J, Vasir B, Uhl L et al (2011) Vaccination with dendritic cell/tumor fusion cells results in cellular and humoral antitumor immune responses in patients with multiple myeloma. Blood 117:393-402
    • (2011) Blood , vol.117 , pp. 393-402
    • Rosenblatt, J.1    Vasir, B.2    Uhl, L.3
  • 174
    • 84879863520 scopus 로고    scopus 로고
    • Vaccination with dendritic cell/tumor fusions following autologous stem cell transplant induces immunologic and clinical responses in multiple myeloma patients
    • 23685836
    • Rosenblatt J, Avivi I, Vasir B et al (2013) Vaccination with dendritic cell/tumor fusions following autologous stem cell transplant induces immunologic and clinical responses in multiple myeloma patients. Clin Cancer Res 19:3640-3648
    • (2013) Clin Cancer Res , vol.19 , pp. 3640-3648
    • Rosenblatt, J.1    Avivi, I.2    Vasir, B.3
  • 175
    • 0036529823 scopus 로고    scopus 로고
    • Immunization against murine multiple myeloma with fusions of dendritic and plasmacytoma cells is potentiated by interleukin 12
    • 11895787
    • Gong J, Koido S, Chen D, Tanaka Y, Huang L, Avigan D, Anderson K, Ohno T, Kufe D (2002) Immunization against murine multiple myeloma with fusions of dendritic and plasmacytoma cells is potentiated by interleukin 12. Blood 99:2512-2517
    • (2002) Blood , vol.99 , pp. 2512-2517
    • Gong, J.1    Koido, S.2    Chen, D.3    Tanaka, Y.4    Huang, L.5    Avigan, D.6    Anderson, K.7    Ohno, T.8    Kufe, D.9
  • 176
    • 84879037075 scopus 로고    scopus 로고
    • Impact of anti-CD25 monoclonal antibody on dendritic cell-tumor fusion vaccine efficacy in a murine melanoma model
    • 3691646 23768240
    • Tan C, Reddy V, Dannull J, Ding E, Nair SK, Tyler DS, Pruitt SK, Lee WT (2013) Impact of anti-CD25 monoclonal antibody on dendritic cell-tumor fusion vaccine efficacy in a murine melanoma model. J Transl Med 11:148
    • (2013) J Transl Med , vol.11 , pp. 148
    • Tan, C.1    Reddy, V.2    Dannull, J.3    Ding, E.4    Nair, S.K.5    Tyler, D.S.6    Pruitt, S.K.7    Lee, W.T.8
  • 177
    • 7444220033 scopus 로고    scopus 로고
    • Vaccination of glioma patients with fusions of dendritic and glioma cells and recombinant human interleukin 12
    • 15534489
    • Kikuchi T, Akasaki Y, Abe T, Fukuda T, Saotome H, Ryan JL, Kufe DW, Ohno T (2004) Vaccination of glioma patients with fusions of dendritic and glioma cells and recombinant human interleukin 12. J Immunother 27:452-459
    • (2004) J Immunother , vol.27 , pp. 452-459
    • Kikuchi, T.1    Akasaki, Y.2    Abe, T.3    Fukuda, T.4    Saotome, H.5    Ryan, J.L.6    Kufe, D.W.7    Ohno, T.8
  • 178
    • 33645105886 scopus 로고    scopus 로고
    • Cancer immunotherapy using dendritic/tumour-fusion vaccine induces elevation of serum anti-nuclear antibody with better clinical responses
    • 1809639 16542363
    • Homma S, Sagawa Y, Ito M, Ohno T, Toda G (2006) Cancer immunotherapy using dendritic/tumour-fusion vaccine induces elevation of serum anti-nuclear antibody with better clinical responses. Clin Exp Immunol 144:41-47
    • (2006) Clin Exp Immunol , vol.144 , pp. 41-47
    • Homma, S.1    Sagawa, Y.2    Ito, M.3    Ohno, T.4    Toda, G.5
  • 179
    • 84861164043 scopus 로고    scopus 로고
    • Sipuleucel-T for the treatment of advanced prostate cancer
    • 22595047
    • Frohlich MW (2012) Sipuleucel-T for the treatment of advanced prostate cancer. Semin Oncol 39:245-252
    • (2012) Semin Oncol , vol.39 , pp. 245-252
    • Frohlich, M.W.1
  • 181
    • 84861610591 scopus 로고    scopus 로고
    • Immunocytokines: A novel class of potent armed antibodies
    • 22289353
    • Pasche N, Neri D (2012) Immunocytokines: a novel class of potent armed antibodies. Drug Discov Today 17:583-590
    • (2012) Drug Discov Today , vol.17 , pp. 583-590
    • Pasche, N.1    Neri, D.2
  • 183
    • 0035294299 scopus 로고    scopus 로고
    • Immunization of HLA-A2+ melanoma patients with MAGE-3 or MelanA peptide-pulsed autologous peripheral blood mononuclear cells plus recombinant human interleukin 12
    • 11300489
    • Gajewski TF, Fallarino F, Ashikari A, Sherman M (2001) Immunization of HLA-A2+ melanoma patients with MAGE-3 or MelanA peptide-pulsed autologous peripheral blood mononuclear cells plus recombinant human interleukin 12. Clin Cancer Res 7:895s-901s
    • (2001) Clin Cancer Res , vol.7
    • Gajewski, T.F.1    Fallarino, F.2    Ashikari, A.3    Sherman, M.4
  • 184
    • 84865744445 scopus 로고    scopus 로고
    • CAR T cells transform to trucks: Chimeric antigen receptor-redirected T cells engineered to deliver inducible IL-12 modulate the tumour stroma to combat cancer
    • 22274776
    • Chmielewski M, Abken H (2012) CAR T cells transform to trucks: chimeric antigen receptor-redirected T cells engineered to deliver inducible IL-12 modulate the tumour stroma to combat cancer. Cancer Immunol Immunother 61:1269-1277
    • (2012) Cancer Immunol Immunother , vol.61 , pp. 1269-1277
    • Chmielewski, M.1    Abken, H.2
  • 185
    • 84876325876 scopus 로고    scopus 로고
    • Chimeric antigen receptor-modified T cells for acute lymphoid leukemia
    • 23527958
    • Grupp SA, Kalos M, Barrett D et al (2013) Chimeric antigen receptor-modified T cells for acute lymphoid leukemia. N Engl J Med 368:1509-1518
    • (2013) N Engl J Med , vol.368 , pp. 1509-1518
    • Grupp, S.A.1    Kalos, M.2    Barrett, D.3
  • 186
    • 80051720194 scopus 로고    scopus 로고
    • Chimeric antigen receptor-modified T cells in chronic lymphoid leukemia
    • 3387277 21830940
    • Porter DL, Levine BL, Kalos M, Bagg A, June CH (2011) Chimeric antigen receptor-modified T cells in chronic lymphoid leukemia. N Engl J Med 365:725-733
    • (2011) N Engl J Med , vol.365 , pp. 725-733
    • Porter, D.L.1    Levine, B.L.2    Kalos, M.3    Bagg, A.4    June, C.H.5
  • 187
    • 84861410440 scopus 로고    scopus 로고
    • Interleukin-12: Clinical usage and molecular markers of cancer susceptibility
    • 22515181
    • Yuzhalin AE, Kutikhin AG (2012) Interleukin-12: clinical usage and molecular markers of cancer susceptibility. Growth Factors 30:176-191
    • (2012) Growth Factors , vol.30 , pp. 176-191
    • Yuzhalin, A.E.1    Kutikhin, A.G.2
  • 188
    • 84877004454 scopus 로고    scopus 로고
    • Cytokine patterns in patients with cancer: A systematic review
    • 23639322
    • Lippitz BE (2013) Cytokine patterns in patients with cancer: a systematic review. Lancet Oncol 14:e218-e228
    • (2013) Lancet Oncol , vol.14
    • Lippitz, B.E.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.