Activation of STAT3 is a marker of poor prognosis in human colorectal cancer

Oncology Reports

Volumn 15, Issue 6, 2006, Pages 1445-1451

  Kusaba, Takafumi ^a   Nakayama, Toshiyuki ^a   Yamazumi, Kazuyuki ^a   Yakata, Yuichi ^a   Yoshizaki, Ayumi ^a   Inoue, Kenichiro ^b   Nagayasu, Takeshi ^a   Sekine, Ichiro ^a  

^a NAGASAKI UNIVERSITY GRADUATE SCHOOL OF BIOMEDICAL SCIENCES   (Japan)

^b Shunkaikai Inoue Hospital   (Japan)

Author keywords

Colorectal cancer; Invasion; Overall survival; p STAT3; Prognosis

Indexed keywords

STAT3 PROTEIN;

ADENOCARCINOMA; ADULT; AGED; ARTICLE; BIOSYNTHESIS; CANCER STAGING; COLORECTAL TUMOR; DISEASE FREE SURVIVAL; FEMALE; HUMAN; LYMPH NODE METASTASIS; MALE; METABOLISM; MIDDLE AGED; PATHOLOGY;

ADENOCARCINOMA; ADULT; AGED; AGED, 80 AND OVER; COLORECTAL NEOPLASMS; DISEASE-FREE SURVIVAL; FEMALE; HUMANS; LYMPHATIC METASTASIS; MALE; MIDDLE AGED; NEOPLASM STAGING; STAT3 TRANSCRIPTION FACTOR;

EID: 33847406439     PISSN: 1021335X     EISSN: 17912431     Source Type: Journal    
DOI: 10.3892/or.15.6.1445     Document Type: Article

References (40)

1. Parkin DM, Pisani P and Ferlay J: Estimates of the worldwide incidence of eighteen major cancers in 1985. Int J Cancer 54: 594-606, 1993. (Pubitemid 23188190)
2. Finlay IG and Pickford IR: Colorectal carcinoma. In: Current Medicine. Lawson DH, (ed). 4th edition. Churchill Livingstone, Edinburgh, pp51-64, 1994.
3. Yiu HY, Whittemore AS and Shibata A: Increasing colorectal cancer incidence rates in Japan. Int J Cancer 109: 777-781, 2004. (Pubitemid 38405628)
4. Newland RC, Dent OF, Lyttle MN, Chapuis PH and Bokey EL: Pathologic determinants of survival associated with colon or rectal cancer with lymph node metastases: a multivariate analysis of 579 patients. Cancer 73: 2076-2082, 1994. (Pubitemid 24107961)
5. Steinberg SM, Barwick KW and Stablein DM: Importance of tumor pathology and morphology in patients with surgically resected colon cancer. Findings from the Gastrointestinal Tumor Study Group. Cancer 58: 1340-1345, 1986. (Pubitemid 16053150)
6. Takeda K, Noguchi K, Shi W, Tanaka T, Matsumoto M, Yoshida N, Kishimoto T and Akira S: Targeted disruption of the mouse Stat3 gene leads to early embryonic lethality. Proc Natl Acad Sci USA 94: 3801-3804, 1997. (Pubitemid 27180453)
7. Darnell JE Jr: STATs and gene regulation. Science 277: 1630-1635, 1997.
8. Zhong Z, Wen Z and Darnell JE Jr: Stat3 and Stat4: members of the family of signal transducers and activators of transcription. Proc Natl Acad Sci USA 91: 4806-4810, 1994. (Pubitemid 24177738)
9. Chakraborty A and Tweardy DJ: Stat3 and G-CSF-induced myeloid differentiation. Leuk Lymphoma 30: 433-442, 1998. (Pubitemid 28393677)
10. Chakraborty A and Tweardy DJ: Granulocyte colony-stimulating factor activates a 72 kDa isoform of Stat3 in human neutrophils. J Leukoc Biol 64: 675-680, 1998. (Pubitemid 28511989)
11. Zhong Z, Wen Z and Darnell JE Jr: Stat3: a STAT family member activated by tyrosine phosphorylation in response to epidermal growth factor and interleukin-6. Science 264: 95-98, 1994. (Pubitemid 24144493)
12. Scholz A, Heinze S, Detjen KM, Peters M, Welzel M, Hauff P, Schirner M, Wiedenmann B and Rosewicz S: Activated signal transducer and activator of transcription 3 (STAT3) supports the malignant phenotype of human pancreatic cancer. Gastroenterology 125: 891-905, 2003. (Pubitemid 37070705)
13. Bowman T, Garcia R, Turkson J and Jove R: STATs in oncogenesis. Oncogene 19: 2474-2488, 2000. (Pubitemid 30339203)
14. Huang M, Page C, Reynolds RK and Lin J: Constitutive activation of stat 3 oncogene product in human ovarian carcinoma cells. Gynecol Oncol 79: 67-73, 2000.
15. Song JI and Grandis JR: STAT signaling in head and neck cancer. Oncogene 19: 2489-2495, 2000. (Pubitemid 30339204)
16. Kusaba T, Nakayama T, Yamazumi K, Yakata Y, Yoshizaki A, Nagayasu T and Sekine I: Expression of p-STAT3 in human colorectal adenocarcinoma and adenoma; correlation with clinicopathological factors. J Clin Pathol 58: 833-838, 2005. (Pubitemid 41113390)
17. Jass JR and Sobin LH: Histological Typing of Intestinal Tumors. 2nd edition. Springer-Verlag, Berlin, 1989.
18. AJCC cancer staging manual. Greene FL, Page DL, Fleming ID, Fritz AG, Balch CM and Haller DG, (eds). 6th edition. Springer, New York, pp127-129, 2002.
19. Dukes CE: The classification of cancer of the rectum. J Pathol Bacteriol 35: 323-332, 1932.
20. Dukes CE: The surgical pathology of rectal cancer. J Clin Pathol 2: 95-98, 1949.
21. Whittaker M and Goligher JC: The prognosis after surgical treatment for carcinoma of the rectum. Br J Surg 63: 384-388, 1976.
22. Seefeld PH and Bargen JA: The spread of cancer of the rectum: invasion of the lymphatics, veins and nerves. Ann Surg 118: 76-89, 1943.
23. Talbot IC, Ritchie S, Leighton M, Hughes AO, Bussey HJ and Morson BC: Invasion of veins by carcinoma of rectum: method of detection, histological features and significance. Histopathology 5: 141-163, 1981. (Pubitemid 11039331)
24. Campbell CL, Jiang Z, Savarese DM and Savarese TM: Increased expression of the interleukin-11 receptor and evidence of STAT3 activation in prostate carcinoma. Am J Pathol 158: 25-32, 2001. (Pubitemid 32096467)
25. Bromberg J: Stat proteins and oncogenesis. J Clin Invest 109: 1139-1142, 2002.
26. Horiguchi A, Oya M, Shimada T, Uchida A, Marumo K and Murai M: Activation of signal transducer and activator of transcription 3 in renal cell carcinoma: a study of incidence and its association with pathological features and clinical outcome. J Urology 168: 762-765, 2002. (Pubitemid 34793359)
27. Masuda M, Suzui M, Yasumatu R, Nakashima T, Kuratomi Y, Azuma K, Tomita K, Komiyama S and Bernard Weinstein I: Constitutive activation of signal transducers and activators of transcription 3 correlates with cyclin D1 overexpression and may provide a novel prognostic marker in head and neck squamous cell carcinoma. Cancer Research 62: 3351-3355, 2002.
28. Dolled-Filhart M, Camp RL, Kowalski DP, Smith BL and Rimm DL: Tissue microarray analysis of signal transducers and activators of transcription 3 (Stat3) and phospho-Stat3 (Tyr705) in node-negative breast cancer shows nuclear localization is associated with a better prognosis. Clin Cancer Res 9: 594-600, 2003. (Pubitemid 36182589)
29. Hsiao JR, Jin YT, Tsai ST, Shiau AL, Wu CL and Su WC: Constitutive activation of STAT3 and STAT5 is present in the majority of nasopharyngeal carcinoma and correlates with better prognosis. Br J Cancer 89: 344-349, 2003.
30. Gong W, Wang L, Yao JC, Ajani JA, Wei D, Aldape KD, Xie K, Sawaya R and Huang S: Expression of activated signal transducer and activator of transcription 3 predicts expression of vascular endothelial growth factor in and angiogenic phenotype of human gastric cancer. Clin Cancer Res 11: 1386-1393, 2005. (Pubitemid 40315217)
31. Ma XT, Wang S, Ye YJ, Du RY, Cui ZR and Somsouk M: Constitutive activation of Stat3 signaling pathway in human colorectal carcinoma. World J Gastroenterol 10: 1569-1573, 2004. (Pubitemid 38786933)
32. Xie TX, Wei D, Liu M, Gao AC, Ali-Osman F, Sawaya R and Huang S: Stat3 activation regulates the expression of matrix metalloproteinase-2 and tumor invasion and metastasis. Oncogene 23: 3550-3560, 2004. (Pubitemid 38658421)
33. Emmert-Buck MR, Roth MJ, Zhuang Z, Campo E, Rozhin J, Sloane BF, Liotta LA and Stetler-Stevenson WG: Increased gelatinase A (MMP-2) and cathepsin B activity in invasive tumor regions of human colon cancer samples. Am J Pathol 145: 1285-1290, 1994. (Pubitemid 24378482)
34. Niu G, Wright KL, Huang M, Song L, Haura E, Turkson J, Zhang S, Wang T, Sinibaldi D, Coppola D, Heller R, Ellis LM, Karras J, Bromberg J, Pardoll D, Jove R and Yu H: Constitutive Stat3 activity up-regulates VEGF expression and tumor angiogenesis. Oncogene 21: 2000-2008, 2002. (Pubitemid 34270888)
35. Wei LH, Kuo ML, Chen CA, Chou CH, Lai KB, Lee CN and Hsieh CY: Interleukin-6 promotes cervical tumor growth by VEGF-dependent angiogenesis via a STAT3 pathway. Oncogene 22: 1517-1527, 2003. (Pubitemid 36390601)
36. Bromberg JF, Wrzeszczynska MH, Devgan G, Zhao Y, Pestell RG, Albanese C and Darnell JE Jr: Stat3 as an oncogene. Cell 98: 295-303, 1999. (Pubitemid 29380565)
37. Nakajima K, Yamanaka Y, Nakae K, Kojima H, Ichiba M, Kiuchi N, Kitaoka T, Fukada T, Hibi M and Hirano T: A central role for Stat3 in IL-6-induced regulation of growth and differentiation in M1 leukemia cells. EMBO J 15: 3651-3658, 1996. (Pubitemid 26239777)
38. Catlett-Falcone R, Landowski TH, Oshiro MM, Turkson J, Levitzki A, Savino R, Ciliberto G, Moscinski L, Fernandez- Luna JL, Nunez G, Dalton WS and Jove R: Constitutive activation of Stat3 signaling confers resistance to apoptosis in human U266 myeloma cells. Immunity 10: 105-115, 1999. (Pubitemid 29077388)
39. Niu G, Bowman T, Huang M, Shivers S, Reintgen D, Daud A, Chang A, Kraker A, Jove R and Yu H: Roles of activated Src and Stat3 signaling in melanoma tumor cell growth. Oncogene 21: 7001-7010, 2002. (Pubitemid 35252974)
40. Kanda N, Seno H, Konda Y, Marusawa H, Kanai M, Nakajima T, Kawashima T, Nanakin A, Sawabu T, Uenoyama Y, Sekikawa A, Kawada M, Suzuki K, Kayahara T, Fukui H, Sawada M and Chiba T: STAT3 is constitutively activated and supports cell survival in association with survivin expression in gastric cancer cells. Oncogene 23: 4921-4929, 2004. (Pubitemid 38932164)