VEGF-1 expression in colorectal cancer is associated with disease localization, stage, and long-term disease-specific survival

Anticancer Research

Volumn 28, Issue 6 B, 2008, Pages 3865-3870

  Bendardaf, Riyad ^a   Buhmeida, Abdelbaset ^a   Hilska, Marja ^a   Laato, Matti ^a   Syrjänen, Stina ^a   Syrjänen, Kari ^a   Collan, Yrjö ^a   Pyrhönen, Seppo ^a  

^a TURKU UNIVERSITY HOSPITAL   (Finland)

Author keywords

Adjuvant therapy; Colorectal cancer; Prognosis; VEGF 1 expression

Indexed keywords

PARAFFIN; UNCLASSIFIED DRUG; VASCULAR ENDOTHELIAL GROWTH FACTOR 1; VASCULOTROPIN;

ADULT; AGED; ARTICLE; CANCER LOCALIZATION; CANCER STAGING; CANCER SURVIVAL; COLORECTAL CANCER; CONTROLLED STUDY; FEMALE; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; MAJOR CLINICAL STUDY; MALE; OUTCOME ASSESSMENT; PRIORITY JOURNAL; PROTEIN EXPRESSION; TISSUE MICROARRAY; TREATMENT RESPONSE;

AGED; COLORECTAL NEOPLASMS; FEMALE; HUMANS; MALE; MIDDLE AGED; NEOPLASM STAGING; SURVIVAL RATE; TREATMENT OUTCOME; VASCULAR ENDOTHELIAL GROWTH FACTOR A;

EID: 58149150071     PISSN: 02507005     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (36)

1. Staib L, Link KH, Blatz A and Beger HG: Surgery of colorectal cancer: surgical morbidity and five- and ten-year results in 2,400 patients - monoinstitutional experience. World J of Surg 26: 59-66, 2002.
2. Young A and Rea D: ABC of colorectal cancer: treatment of advanced disease. BMJ 321: 1278-1281, 2000.
3. Christopoulou A: Chemotherapy in metastatic colorectal cancer. Tech Coloproctol 8(Suppl 1): S43-46, 2004.
4. Daly ME, Makris A, Reed M and Lewis CE: Hemostatic regulators of tumor angiogenesis: a source of antiangiogenic agents for cancer treatment? J Natl Cancer Inst 95: 1660-1673, 2003.
5. Folkman J: What is the evidence that tumors are angiogenesis dependent? J Natl Cancer Inst 82: 4-6, 1990.
6. Hanahan D and Folkman J: Patterns and emerging mechanisms of the angiogenic switch during tumorigenesis. Cell 86: 353-364, 1996.
7. Ellis LM: A targeted approach for antiangiogenic therapy of metastatic human colon cancer. Am Surg 69: 3-10, 2003.
8. Guba M, Seeliger H, Kleespies A, Jauch KW and Bruns C: Vascular endothelial growth factor in colorectal cancer. Int J Colorectal Dis 19: 510-517, 2004.
9. Clasper S, Royston D, Baban D, Cao Y, Ewers S, Butz S, Vestweber D and Jackson DG: A novel gene expression profile in lymphatics associated with tumor growth and nodal metastasis. Cancer Res 68: 7293-7303, 2008.
10. Choi JH, Oh YH, Park YW, Baik HK, Lee YY and Kim IS: Correlation of vascular endothelial growth factor-D expression and VEGFR-3-positive vessel density with lymph node metastasis in gastric carcinoma. J Korean Med Sci 23: 592-597, 2008.
11. Lee JC, Chow NH, Wang ST and Huang SM: Prognostic value of vascular endothelial growth factor expression in colorectal cancer patients. Eur J Cancer 36: 748-753, 2000.
12. Kondo Y, Arii, S, Mori A, Furutani M, Chiba T and Imamura M: Enhancement of angiogenesis, tumor growth and metastasis by transfection of vascular endothelial growth factor into LoVo human colon cancer cell line. Clin Cancer Res 6: 622-630, 2000.
13. Ishigami SI, Arii S, Furutani M, Niwano M, Harada T, Mizumoto M, Mori A, Onodera H and Imamura M: Predictive value of vascular endothelial growth factor (VEGF) in metastasis and prognosis of human colorectal cancer. Br J Cancer 78: 1379-1384, 1998.
14. Ferroni P, Palmirotta R, Spila A, Martini F, Formica V, Portarena I, Del Monte G, Buonomo O, Roselli M and Guadagni F: Prognostic value of carcinoembryonic antigen and vascular endothelial growth factor tumor tissue content in colorectal cancer. Oncology 71: 176-184, 2006.
15. Moehler M, Fring C, Mueller A, Gockel I, Schimanski CC, Biesterfeld S, Galle PR and Holtmann MH: VEGF-D expression correlates with colorectal cancer aggressiveness and is down-regulated by cetuximab. World J Gastroenterol 14: 4156-4167, 2008.
16. Hu WG, Li JW, Feng B, Beveridge M, Yue F, Lu A. G, Ma JJ, Wang ML, Guo Y, Jin XL and Zheng MH: Vascular endothelial growth factors C and D represent novel prognostic markers in colorectal carcinoma using quantitative image analysis. Eur Surg Res 39: 229-238, 2007.
17. Des Guetz, G, Uzzan, B, Nicolas P, Cucherat M, Morere JF, Benamouzig R, Breau JL and Perret GY: Microvessel density and VEGF expression are prognostic factors in colorectal cancer. Meta-analysis of the literature. Br J Cancer 94: 1823-1832, 2006.
18. Bufill JA: Colorectal cancer: evidence for distinct genetic categories based on proximal or distal tumor location. Ann Intern Med 113: 779-788, 1990.
19. Bleeker WA, Hayes VM, Karrenbeld A, Hofstra RM, Hermans J, Buys CC and Plukker JT: Impact of KRAS and TP53 mutations on survival in patients with left- and right-sided Dukes' C colon cancer. Am J Gastroenterol 95: 2953-2957, 2000.
20. Elsaleh H, Joseph D, Grieu F, Zeps N, Spry N and Iacopetta B: Association of tumour site and sex with survival benefit from adjuvant chemotherapy in colorectal cancer. Lancet 355: 1745-1750, 2000.
21. Callagy G, Dimitriadis E, Harmey J, Bouchier-Hayes D, Leader M and Kay E: Immunohistochemical measurement of tumor vascular endothelial growth factor in breast cancer. A more reliable predictor of tumor stage than microvessel density or serum vascular endothelial growth factor. Appl Immunohistochem Mol Morphol 8: 104-109, 2000.
22. George ML, Eccles SA, Tutton MG, Abulafi AM and Swift RI: Correlation of plasma and serum vascular endothelial growth factor levels with platelet count in colorectal cancer: clinical evidence of platelet scavenging? Clin Cancer Res 6: 3147-3152, 2000.
23. Chae YS, Kim JG, Sohn SK, Cho YY, Ahn BM, Moon JH, Jeon SW, Park JY, Lee IT, Choi GS and Jun SH: Association of vascular endothelial growth factor gene polymorphisms with susceptibility and clinicopathologic characteristics of colorectal cancer. J Korean Med Sci 23: 421-427, 2008.
24. Staton CA, Chetwood AS, Cameron IC, Cross SS, Brown NJ and Reed MW: The angiogenic switch occurs at the adenoma stage of the adenoma carcinoma sequence in colorectal cancer. Gut 56: 1426-1432, 2007.
25. Kumar H, Heer K, Lee PW, Duthie GS, MacDonald AW, Greenman J, Kerin MJ and Monson JR: Preoperative serum vascular endothelial growth factor can predict stage in colorectal cancer. Clin Cancer Res 4: 1279-1285, 1998.
26. Gil-Bazo I, Catalan Goni V, Alonso Gutierrez A, Rodriguez Rodriguez J, Paramo Fernandez JA, de la Camara Gomez J, Hernandez Lizoain JL and Garcia-Foncillas Lopez J: Impact of surgery and chemotherapy on von Willebrand factor and vascular endothelial growth factor levels in colorectal cancer. Clin Transl Oncol 7: 150-155, 2005.
27. Chin KF, Greenman J, Gardiner E, Kumar H, Topping K and Monson J: Pre-operative serum vascular endothelial growth factor can select patients for adjuvant treatment after curative resection in colorectal cancer. Br J Cancer 83: 1425-1431, 2000.
28. Simiantonaki N, Taxeidis M, Jayasinghe C and Kirkpatrick CJ: Epithelial expression of VEGF receptors in colorectal carcinomas and their relationship to metastatic status. Anticancer Res 27: 3245-3250, 2007.
29. Wang S, Liu H, Ren L, Pan Y and Zhang Y: Inhibiting colorectal carcinoma growth and metastasis by blocking the expression of VEGF using RNA interference. Neoplasia 10: 399-407, 2008.
30. Ferroni P, Spila A, Martini F, D'Alessandro R, Mariotti S, Del Monte G, Graziano P, Buonomo O, Guadagni F and Roselli M: Prognostic value of vascular endothelial growth factor tumor tissue content of colorectal cancer. Oncology 69: 145-153, 2005.
31. Ogata Y, Matono K, Mizobe T, Ishibashi N, Mori S, Akagi Y, Ikeda S, Ozasa H, Murakami H and Shirouzu K: The expression of vascular endothelial growth factor determines the efficacy of postoperative adjuvant chemotherapy using oral fluoropyrimidines in stage II or III colorectal cancer. Oncol Rep 15: 1111-1116, 2006.
32. Takahashi Y, Kitadai Y, Bucana CD, Cleary KR and Ellis LM: Expression of vascular endothelial growth factor and its receptor, KDR, correlates with vascularity, metastasis and proliferation of human colon cancer. Cancer Res 55: 3964-3968, 1995.
33. Takahashi Y, Tucker SL, Kitadai Y, Koura AN, Bucana CD, Cleary KR and Ellis LM: Vessel counts and expression of vascular endothelial growth factor as prognostic factors in node-negative colon cancer. Arch Surg 132: 541-546, 1997.
34. Elzagheid A, Buhmeida A, Korkeila E, Collan,Y, Syrjanen K and Pyrhonen S: Nuclear beta-catenin expression as a prognostic factor in advanced colorectal carcinoma. World J Gastroenterol 14: 3866-3871, 2008.
35. Hilska M, Collan YU, VJ OL, Kossi J, Hirsimaki P, Laato M and Roberts PJ: The significance of tumor markers for proliferation and apoptosis in predicting survival in colorectal cancer. Dis Colon Rectum 48: 2197-2208, 2005.
36. Hilska M, Roberts PJ, Collan YU, Laine VJ, Kossi J, Hirsimaki P, Rahkonen O and Laato M: Prognostic significance of matrix metalloproteinases-1, -2, -7 and -13 and tissue inhibitors of metalloproteinases-1, -2, -3 and -4 in colorectal cancer. Int J Cancer 121: 714-723, 2007.