-
3
-
-
84867726955
-
Animal models of inflammatory bowel diseases: Illuminating the pathogenesis of colitis, ileitis and cancer
-
Neurath MF. Animal models of inflammatory bowel diseases: illuminating the pathogenesis of colitis, ileitis and cancer. Dig Dis 2012;30(Suppl 1):91-4.
-
(2012)
Dig Dis
, vol.30
, pp. 91-94
-
-
Neurath, M.F.1
-
4
-
-
0028861975
-
Antibodies to interleukin 12 abrogate established experimental colitis in mice
-
Neurath MF, Fuss I, Kelsall BL, et al. Antibodies to interleukin 12 abrogate established experimental colitis in mice. J Exp Med 1995;182:1281-90.
-
(1995)
J Exp Med
, vol.182
, pp. 1281-1290
-
-
Neurath, M.F.1
Fuss, I.2
Kelsall, B.L.3
-
5
-
-
23244455992
-
Interleukin-13 is the key effector Th2 cytokine in ulcerative colitis that affects epithelial tight junctions, apoptosis, and cell restitution
-
Heller F, Florian P, Bojarski C, et al. Interleukin-13 is the key effector Th2 cytokine in ulcerative colitis that affects epithelial tight junctions, apoptosis, and cell restitution. Gastroenterology 2005;129:550-64.
-
(2005)
Gastroenterology
, vol.129
, pp. 550-564
-
-
Heller, F.1
Florian, P.2
Bojarski, C.3
-
6
-
-
0036850908
-
Oxazolone colitis, a Th2 colitis model resembling ulcerative colitis, is mediated by IL-13-producing NK-T cells
-
Heller F, Fuss IJ, Nieuwenhuis EE, et al. Oxazolone colitis, a Th2 colitis model resembling ulcerative colitis, is mediated by IL-13-producing NK-T cells. Immunity 2002;17:629-38.
-
(2002)
Immunity
, vol.17
, pp. 629-638
-
-
Heller, F.1
Fuss, I.J.2
Nieuwenhuis, E.E.3
-
8
-
-
0022640843
-
Two types of murine helper T cell clone. I. Definition according to profiles of lymphokine activities and secreted proteins
-
Mosmann TR, Cherwinski H, Bond MW, et al. Two types of murine helper T cell clone. I. Definition according to profiles of lymphokine activities and secreted proteins. J Immunol 1986;136:2348-57.
-
(1986)
J Immunol
, vol.136
, pp. 2348-2357
-
-
Mosmann, T.R.1
Cherwinski, H.2
Bond, M.W.3
-
9
-
-
0024353079
-
TH1 and TH2 cells: Different patterns of lymphokine secretion lead to different functional properties
-
Mosmann TR, Coffman RL. TH1 and TH2 cells: different patterns of lymphokine secretion lead to different functional properties. Annu Rev Immunol 1989;7:145-73.
-
(1989)
Annu Rev Immunol
, vol.7
, pp. 145-173
-
-
Mosmann, T.R.1
Coffman, R.L.2
-
10
-
-
83555163767
-
Functional relevance of T helper 17 (Th17) cells and the IL-17 cytokine family in inflammatory bowel disease
-
Hundorfean G, Neurath MF, Mudter J. Functional relevance of T helper 17 (Th17) cells and the IL-17 cytokine family in inflammatory bowel disease. Inflamm Bowel Dis 2012;18:180-6.
-
(2012)
Inflamm Bowel Dis
, vol.18
, pp. 180-186
-
-
Hundorfean, G.1
Neurath, M.F.2
Mudter, J.3
-
11
-
-
56549104968
-
IL23 differentially regulates the Th1/Th17 balance in ulcerative colitis and Crohn's disease
-
Kobayashi T, Okamoto S, Hisamatsu T, et al. IL23 differentially regulates the Th1/Th17 balance in ulcerative colitis and Crohn's disease. Gut 2008;57:1682-9.
-
(2008)
Gut
, vol.57
, pp. 1682-1689
-
-
Kobayashi, T.1
Okamoto, S.2
Hisamatsu, T.3
-
12
-
-
84873638253
-
Th9 cells: Differentiation and disease
-
Kaplan MH. Th9 cells: differentiation and disease. Immunol Rev 2013;252:104-15.
-
(2013)
Immunol Rev
, vol.252
, pp. 104-115
-
-
Kaplan, M.H.1
-
13
-
-
72849131815
-
Th22 cells represent a distinct human T cell subset involved in epidermal immunity and remodeling
-
Eyerich S, Eyerich K, Pennino D, et al. Th22 cells represent a distinct human T cell subset involved in epidermal immunity and remodeling. J Clin Invest 2009;119:3573-85.
-
(2009)
J Clin Invest
, vol.119
, pp. 3573-3585
-
-
Eyerich, S.1
Eyerich, K.2
Pennino, D.3
-
14
-
-
80054927155
-
An IL-9 fate reporter demonstrates the induction of an innate IL-9 response in lung inflammation
-
Wilhelm C, Hirota K, Stieglitz B, et al. An IL-9 fate reporter demonstrates the induction of an innate IL-9 response in lung inflammation. Nat Immunol 2011;12:1071-7.
-
(2011)
Nat Immunol
, vol.12
, pp. 1071-1077
-
-
Wilhelm, C.1
Hirota, K.2
Stieglitz, B.3
-
15
-
-
84862615185
-
The many lives of IL-9: A question of survival?
-
Wilhelm C, Turner JE, Van Snick J, et al. The many lives of IL-9: a question of survival? Nat Immunol 2012;13:637-41.
-
(2012)
Nat Immunol
, vol.13
, pp. 637-641
-
-
Wilhelm, C.1
Turner, J.E.2
Van Snick, J.3
-
16
-
-
56349093347
-
IL-4 inhibits TGF-beta-induced Foxp3+ T cells and, together with TGF-beta, generates IL-9+ IL-10+ Foxp3(-) effector T cells
-
Dardalhon V, Awasthi A, Kwon H, et al. IL-4 inhibits TGF-beta-induced Foxp3+ T cells and, together with TGF-beta, generates IL-9+ IL-10+ Foxp3(-) effector T cells. Nat Immunol 2008;9:1347-55.
-
(2008)
Nat Immunol
, vol.9
, pp. 1347-1355
-
-
Dardalhon, V.1
Awasthi, A.2
Kwon, H.3
-
17
-
-
56349154943
-
Transforming growth factor-beta 'reprograms' the differentiation of T helper 2 cells and promotes an interleukin 9-producing subset
-
Veldhoen M, Uyttenhove C, van Snick J, et al. Transforming growth factor-beta 'reprograms' the differentiation of T helper 2 cells and promotes an interleukin 9-producing subset. Nat Immunol 2008;9:1341-6.
-
(2008)
Nat Immunol
, vol.9
, pp. 1341-1346
-
-
Veldhoen, M.1
Uyttenhove, C.2
Van Snick, J.3
-
18
-
-
84863010992
-
STAT6-dependent regulation of Th9 development
-
Goswami R, Jabeen R, Yagi R, et al. STAT6-dependent regulation of Th9 development. J Immunol 2012;188:968-75.
-
(2012)
J Immunol
, vol.188
, pp. 968-975
-
-
Goswami, R.1
Jabeen, R.2
Yagi, R.3
-
19
-
-
77955902281
-
Interferon-regulatory factor 4 is essential for the developmental program of T helper 9 cells
-
Staudt V, Bothur E, Klein M, et al. Interferon-regulatory factor 4 is essential for the developmental program of T helper 9 cells. Immunity 2010;33:192-202.
-
(2010)
Immunity
, vol.33
, pp. 192-202
-
-
Staudt, V.1
Bothur, E.2
Klein, M.3
-
20
-
-
77952584843
-
The transcription factor PU.1 is required for the development of IL-9-producing T cells and allergic inflammation
-
Chang HC, Sehra S, Goswami R, et al. The transcription factor PU.1 is required for the development of IL-9-producing T cells and allergic inflammation. Nat Immunol 2010;11:527-34.
-
(2010)
Nat Immunol
, vol.11
, pp. 527-534
-
-
Chang, H.C.1
Sehra, S.2
Goswami, R.3
-
21
-
-
46749154270
-
The transcription factor IFN regulatory factor-4 controls experimental colitis in mice via T cell-derived IL-6
-
Mudter J, Amoussina L, Schenk M, et al. The transcription factor IFN regulatory factor-4 controls experimental colitis in mice via T cell-derived IL-6. J Clin Invest 2008;118:2415-26.
-
(2008)
J Clin Invest
, vol.118
, pp. 2415-2426
-
-
Mudter, J.1
Amoussina, L.2
Schenk, M.3
-
22
-
-
79955835559
-
IRF4 regulates IL-17A promoter activity and controls RORgammat-dependent Th17 colitis in vivo
-
Mudter J, Yu J, Zufferey C, et al. IRF4 regulates IL-17A promoter activity and controls RORgammat-dependent Th17 colitis in vivo. Inflamm Bowel Dis 2011;17:1343-58.
-
(2011)
Inflamm Bowel Dis
, vol.17
, pp. 1343-1358
-
-
Mudter, J.1
Yu, J.2
Zufferey, C.3
-
23
-
-
34848893583
-
Histologic inflammation is a risk factor for progression to colorectal neoplasia in ulcerative colitis: A cohort study
-
quiz 340-1
-
Gupta RB, Harpaz N, Itzkowitz S, et al. Histologic inflammation is a risk factor for progression to colorectal neoplasia in ulcerative colitis: a cohort study. Gastroenterology 2007;133:1099-105; quiz 340-1.
-
(2007)
Gastroenterology
, vol.133
, pp. 1099-1105
-
-
Gupta, R.B.1
Harpaz, N.2
Itzkowitz, S.3
-
24
-
-
84874056674
-
IL-9-producing invariant NKT cells protect against DSS-induced colitis in an IL-4-dependent manner
-
Kim HS, Chung DH. IL-9-producing invariant NKT cells protect against DSS-induced colitis in an IL-4-dependent manner. Mucosal Immunol 2013;6:347-57.
-
(2013)
Mucosal Immunol
, vol.6
, pp. 347-357
-
-
Kim, H.S.1
Chung, D.H.2
-
25
-
-
0035865357
-
Functional expression of IL-9 receptor by human neutrophils from asthmatic donors: Role in IL-8 release
-
Abdelilah S, Latifa K, Esra N, et al. Functional expression of IL-9 receptor by human neutrophils from asthmatic donors: role in IL-8 release. J Immunol 2001;166:2768-74.
-
(2001)
J Immunol
, vol.166
, pp. 2768-2774
-
-
Abdelilah, S.1
Latifa, K.2
Esra, N.3
-
26
-
-
84859387081
-
Neutrophil function: From mechanisms to disease
-
Amulic B, Cazalet C, Hayes GL, et al. Neutrophil function: from mechanisms to disease. Annu Rev Immunol 2012;30:459-89.
-
(2012)
Annu Rev Immunol
, vol.30
, pp. 459-489
-
-
Amulic, B.1
Cazalet, C.2
Hayes, G.L.3
-
27
-
-
84860557456
-
New therapies for inflammatory bowel disease: From the bench to the bedside
-
Danese S. New therapies for inflammatory bowel disease: from the bench to the bedside. Gut 2012;61:918-32.
-
(2012)
Gut
, vol.61
, pp. 918-932
-
-
Danese, S.1
-
28
-
-
84880269392
-
How cytokine networks fuel inflammation: Toward a cytokine-based disease taxonomy
-
Schett G, Elewaut D, McInnes IB, et al. How Cytokine Networks Fuel Inflammation: toward a cytokine-based disease taxonomy. Nat Med 2013;19:822-4.
-
(2013)
Nat Med
, vol.19
, pp. 822-824
-
-
Schett, G.1
Elewaut, D.2
McInnes, I.B.3
-
29
-
-
84878667737
-
Adalimumab prevents barrier dysfunction and antagonizes distinct effects of TNF-alpha on tight junction proteins and signaling pathways in intestinal epithelial cells
-
Fischer A, Gluth M, Pape UF, et al. Adalimumab prevents barrier dysfunction and antagonizes distinct effects of TNF-alpha on tight junction proteins and signaling pathways in intestinal epithelial cells. Am J Physiol Gastrointest Liver Physiol 2013;304:G970-9.
-
(2013)
Am J Physiol Gastrointest Liver Physiol
, vol.304
, pp. G970-G979
-
-
Fischer, A.1
Gluth, M.2
Pape, U.F.3
-
31
-
-
33744481749
-
Origins of the T(H)1-T(H)2 model: A personal perspective
-
Coffman RL. Origins of the T(H)1-T(H)2 model: a personal perspective. Nat Immunol 2006;7:539-41.
-
(2006)
Nat Immunol
, vol.7
, pp. 539-541
-
-
Coffman, R.L.1
-
32
-
-
79959736367
-
Calprotectin, calgranulin C, and other members of the s100 protein family in inflammatory bowel disease
-
Manolakis AC, Kapsoritakis AN, Tiaka EK, et al. Calprotectin, calgranulin C, and other members of the s100 protein family in inflammatory bowel disease. Dig Dis Sci 2011;56:1601-11.
-
(2011)
Dig Dis Sci
, vol.56
, pp. 1601-1611
-
-
Manolakis, A.C.1
Kapsoritakis, A.N.2
Tiaka, E.K.3
-
33
-
-
1642634949
-
Interleukin 9 production in the lungs of infants with severe respiratory syncytial virus bronchiolitis
-
McNamara PS, Flanagan BF, Baldwin LM, et al. Interleukin 9 production in the lungs of infants with severe respiratory syncytial virus bronchiolitis. Lancet 2004;363:1031-7.
-
(2004)
Lancet
, vol.363
, pp. 1031-1037
-
-
McNamara, P.S.1
Flanagan, B.F.2
Baldwin, L.M.3
-
34
-
-
77952482484
-
Human CD4 memory T cells can become CD4+IL-9+ T cells
-
Putheti P, Awasthi A, Popoola J, et al. Human CD4 memory T cells can become CD4+IL-9+ T cells. PloS ONE 2010;5:e8706.
-
(2010)
PloS ONE
, vol.5
, pp. e8706
-
-
Putheti, P.1
Awasthi, A.2
Popoola, J.3
-
35
-
-
84893388714
-
Human TH9 cells are skin-tropic and have autocrine and paracrine proinflammatory capacity
-
Schlapbach C, Gehad A, Yang C, et al. Human TH9 cells are skin-tropic and have autocrine and paracrine proinflammatory capacity. Sci Transl Med 2014;6:219ra8.
-
(2014)
Sci Transl Med
, vol.6
, pp. 219ra8
-
-
Schlapbach, C.1
Gehad, A.2
Yang, C.3
-
36
-
-
77955658181
-
Regulation of human Th9 differentiation by type i interferons and IL-21
-
Wong MT, Ye JJ, Alonso MN, et al. Regulation of human Th9 differentiation by type I interferons and IL-21. Immunol Cell Biol 2010;88:624-31.
-
(2010)
Immunol Cell Biol
, vol.88
, pp. 624-631
-
-
Wong, M.T.1
Ye, J.J.2
Alonso, M.N.3
-
37
-
-
0032733508
-
Expression of lymphocyte-endothelial receptor-ligand pairs, alpha4beta7/MAdCAM-1 and OX40/OX40 ligand in the colon and jejunum of patients with inflammatory bowel disease
-
Souza HS, Elia CC, Spencer J, et al. Expression of lymphocyte-endothelial receptor-ligand pairs, alpha4beta7/MAdCAM-1 and OX40/OX40 ligand in the colon and jejunum of patients with inflammatory bowel disease. Gut 1999;45:856-63.
-
(1999)
Gut
, vol.45
, pp. 856-863
-
-
Souza, H.S.1
Elia, C.C.2
Spencer, J.3
-
38
-
-
20444469332
-
Treatment of ulcerative colitis with a humanized antibody to the alpha4beta7 integrin
-
Feagan BG, Greenberg GR, Wild G, et al. Treatment of ulcerative colitis with a humanized antibody to the alpha4beta7 integrin. N Engl J Med 2005;352:2499-507.
-
(2005)
N Engl J Med
, vol.352
, pp. 2499-2507
-
-
Feagan, B.G.1
Greenberg, G.R.2
Wild, G.3
-
39
-
-
84890916350
-
New targets for mucosal healing and therapy in inflammatory bowel diseases
-
Neurath MF. New targets for mucosal healing and therapy in inflammatory bowel diseases. Mucosal Immunol 2014;7:6-19.
-
(2014)
Mucosal Immunol
, vol.7
, pp. 6-19
-
-
Neurath, M.F.1
-
40
-
-
0028243704
-
Isolation and characterization of the human interleukin-9 receptor gene
-
Chang MS, Engel G, Benedict C, et al. Isolation and characterization of the human interleukin-9 receptor gene. Blood 1994;83:3199-205.
-
(1994)
Blood
, vol.83
, pp. 3199-3205
-
-
Chang, M.S.1
Engel, G.2
Benedict, C.3
-
41
-
-
0032168074
-
Human neutrophils express the interleukin-15 receptor alpha chain (IL-15Ralpha) but not the IL-9Ralpha component
-
Girard D, Boiani N, Beaulieu AD. Human neutrophils express the interleukin-15 receptor alpha chain (IL-15Ralpha) but not the IL-9Ralpha component. Clin Immunol Immunopathol 1998;88:232-40.
-
(1998)
Clin Immunol Immunopathol
, vol.88
, pp. 232-240
-
-
Girard, D.1
Boiani, N.2
Beaulieu, A.D.3
-
42
-
-
51449114896
-
Accumulation, activation, and survival of neutrophils in ulcerative colitis: Regulation by locally produced factors in the colon and impact of steroid treatment
-
Lampinen M, Sangfelt P, Taha Y, et al. Accumulation, activation, and survival of neutrophils in ulcerative colitis: regulation by locally produced factors in the colon and impact of steroid treatment. Int J Colorectal Dis 2008;23:939-46.
-
(2008)
Int J Colorectal Dis
, vol.23
, pp. 939-946
-
-
Lampinen, M.1
Sangfelt, P.2
Taha, Y.3
-
43
-
-
79960829290
-
Neutrophils in the activation and regulation of innate and adaptive immunity
-
Mantovani A, Cassatella MA, Costantini C, et al. Neutrophils in the activation and regulation of innate and adaptive immunity. Nat Rev Immunol 2011;11:519-31.
-
(2011)
Nat Rev Immunol
, vol.11
, pp. 519-531
-
-
Mantovani, A.1
Cassatella, M.A.2
Costantini, C.3
-
44
-
-
0034655090
-
Granulocyte-macrophage colony-stimulating factor delays neutrophil constitutive apoptosis through phosphoinositide 3-kinase and extracellular signal-regulated kinase pathways
-
Klein JB, Rane MJ, Scherzer JA, et al. Granulocyte-macrophage colony-stimulating factor delays neutrophil constitutive apoptosis through phosphoinositide 3-kinase and extracellular signal-regulated kinase pathways. J Immunol 2000;164:4286-91.
-
(2000)
J Immunol
, vol.164
, pp. 4286-4291
-
-
Klein, J.B.1
Rane, M.J.2
Scherzer, J.A.3
-
45
-
-
0033038648
-
IL-9 induces chemokine expression in lung epithelial cells and baseline airway eosinophilia in transgenic mice
-
Dong Q, Louahed J, Vink A, et al. IL-9 induces chemokine expression in lung epithelial cells and baseline airway eosinophilia in transgenic mice. Eur J Immunol 1999;29:2130-9.
-
(1999)
Eur J Immunol
, vol.29
, pp. 2130-2139
-
-
Dong, Q.1
Louahed, J.2
Vink, A.3
-
46
-
-
12344312064
-
IL-9 and its receptor: From signal transduction to tumorigenesis
-
Knoops L, Renauld JC. IL-9 and its receptor: from signal transduction to tumorigenesis. Growth Factors 2004;22:207-15.
-
(2004)
Growth Factors
, vol.22
, pp. 207-215
-
-
Knoops, L.1
Renauld, J.C.2
-
47
-
-
38449084547
-
Determination of drug permeability and prediction of drug absorption in Caco-2 monolayers
-
Hubatsch I, Ragnarsson EG, Artursson P. Determination of drug permeability and prediction of drug absorption in Caco-2 monolayers. Nat Protoc 2007;2:2111-19.
-
(2007)
Nat Protoc
, vol.2
, pp. 2111-2119
-
-
Hubatsch, I.1
Ragnarsson, E.G.2
Artursson, P.3
-
48
-
-
0029944560
-
IL-8 induces T cell chemotaxis, suppresses IL-4, and up-regulates IL-8 production by CD4+ T cells
-
Gesser B, Lund M, Lohse N, et al. IL-8 induces T cell chemotaxis, suppresses IL-4, and up-regulates IL-8 production by CD4+ T cells. J Leukoc Biol 1996;59:407-11.
-
(1996)
J Leukoc Biol
, vol.59
, pp. 407-411
-
-
Gesser, B.1
Lund, M.2
Lohse, N.3
-
49
-
-
0028817350
-
Interleukin-8 is a potent mediator of eosinophil chemotaxis through endothelium and epithelium
-
Erger RA, Casale TB. Interleukin-8 is a potent mediator of eosinophil chemotaxis through endothelium and epithelium. Am J Physiol 1995;268:L117-22.
-
(1995)
Am J Physiol
, vol.268
, pp. L117-L122
-
-
Erger, R.A.1
Casale, T.B.2
|