-
1
-
-
0035850402
-
The continuing epidemics of obesity and diabetes in the United States
-
Mokdad AH, Bowman BA, Ford ES, et al. The continuing epidemics of obesity and diabetes in the United States. JAMA 2001;286:1195-1200.
-
(2001)
JAMA
, vol.286
, pp. 1195-1200
-
-
Mokdad, A.H.1
Bowman, B.A.2
Ford, E.S.3
-
3
-
-
0028139089
-
Positional cloning of the mouse obese gene and its human homologue
-
Zhang Y, Proenca R, Maffei M, et al. Positional cloning of the mouse obese gene and its human homologue. Nature 1994;372:425-432.
-
(1994)
Nature
, vol.372
, pp. 425-432
-
-
Zhang, Y.1
Proenca, R.2
Maffei, M.3
-
5
-
-
0014031401
-
Distinction of brown from white adipose tissue
-
Hull D, Segall MM. Distinction of brown from white adipose tissue. Nature 1966;212:469-472.
-
(1966)
Nature
, vol.212
, pp. 469-472
-
-
Hull, D.1
Segall, M.M.2
-
6
-
-
84984082775
-
A comparison of the histological organization and histochemical reactions of brown fat and ordinary fat
-
Fawcett DW. A comparison of the histological organization and histochemical reactions of brown fat and ordinary fat. . Morphol 1952;90:363-372.
-
(1952)
J Morphol
, vol.90
, pp. 363-372
-
-
Fawcett, D.W.1
-
7
-
-
0029970595
-
Tyrosine hydroxylase, neuropeptide Y, substance P, calcitonin gene-related peptide and vasoactive intestinal peptide in nerves of rat periovarian adipose tissue: an immunohistochemical and ultrastructural investigation
-
Giordano A, Morroni M, Santone G, et al. Tyrosine hydroxylase, neuropeptide Y, substance P, calcitonin gene-related peptide and vasoactive intestinal peptide in nerves of rat periovarian adipose tissue: an immunohistochemical and ultrastructural investigation. . Neurocytol 1996;25:125-136.
-
(1996)
J Neurocytol
, vol.25
, pp. 125-136
-
-
Giordano, A.1
Morroni, M.2
Santone, G.3
-
8
-
-
0031765344
-
Innervation of mammalian white adipose tissue: implications for the regulation of total body fat
-
Bartness TJ, Bamshad M. Innervation of mammalian white adipose tissue: implications for the regulation of total body fat. Am J Physiol 1998;275: R1399-1411.
-
(1998)
Am J Physiol
, vol.275
, pp. R1399-R1411
-
-
Bartness, T.J.1
Bamshad, M.2
-
9
-
-
0004236075
-
-
Milan, Italy: Editrice Kurtis
-
Cinti S. The adipose organ. Milan, Italy: Editrice Kurtis, 1999.
-
(1999)
The adipose organ.
-
-
Cinti, S.1
-
10
-
-
0014830814
-
Structure-function relationships in the adipose cell, I: ultrastructure of the isolated adipose cell
-
Cushman SW. Structure-function relationships in the adipose cell, I: ultrastructure of the isolated adipose cell. . Cell Biol 1970;46:326-341.
-
(1970)
J Cell Biol
, vol.46
, pp. 326-341
-
-
Cushman, S.W.1
-
11
-
-
0014833184
-
Structure-function relationships in the adipose cell, II: pinocytosis and factors influencing its activity in the isolated adipose cell
-
Cushman SW. Structure-function relationships in the adipose cell, II: pinocytosis and factors influencing its activity in the isolated adipose cell. . Cell Biol 1970;6:342-353.
-
(1970)
J Cell Biol
, vol.6
, pp. 342-353
-
-
Cushman, S.W.1
-
12
-
-
0025772167
-
Perilipin, a major hormonally regulated adipocyte-specific phosphoprotein associated with the periphery of lipid storage droplets
-
Greenberg AS, Egan JJ, Wek SA, et al. Perilipin, a major hormonally regulated adipocyte-specific phosphoprotein associated with the periphery of lipid storage droplets. . Biol Chem 1990;11341-11346.
-
(1990)
J Biol Chem
, pp. 11341-11346
-
-
Greenberg, A.S.1
Egan, J.J.2
Wek, S.A.3
-
13
-
-
0029972402
-
The regulation of adipose tissue distribution in humans
-
Bjorntorp P. The regulation of adipose tissue distribution in humans. Int J Obes Relat Metab Disord 1996;20:291-302.
-
(1996)
Int J Obes Relat Metab Disord
, vol.20
, pp. 291-302
-
-
Bjorntorp, P.1
-
14
-
-
0034119138
-
The perils of portliness: causes and consequences of visceral adiposity
-
Montague CT, O'Rahilly S. The perils of portliness: causes and consequences of visceral adiposity. Diabetes 2000;49:883-888.
-
(2000)
Diabetes
, vol.49
, pp. 883-888
-
-
Montague, C.T.1
O'Rahilly, S.2
-
15
-
-
0016161878
-
A review of development of adipose cellularity in man and animals
-
Stern JS, Greenwood MR. A review of development of adipose cellularity in man and animals. Fed Proc 1974;33:1952-1955.
-
(1974)
Fed Proc
, vol.33
, pp. 1952-1955
-
-
Stern, J.S.1
Greenwood, M.R.2
-
16
-
-
0016361825
-
Size, number and function of adipose tissue cells in human obesity
-
Bjorntorp P. Size, number and function of adipose tissue cells in human obesity. Horm Metab Res 1974[Suppl 4]:77-83.
-
(1974)
Horm Metab Res
, pp. 77-83
-
-
Bjorntorp, P.1
-
17
-
-
0000828672
-
Diet-induced adipocyte number increase in adult rats: a new model of obesity
-
Faust IM, Johnson PR, Stern JS, et al. Diet-induced adipocyte number increase in adult rats: a new model of obesity. Am J Physiol 1978;235:E279-E286.
-
(1978)
Am J Physiol
, vol.235
, pp. E279-E286
-
-
Faust, I.M.1
Johnson, P.R.2
Stern, J.S.3
-
18
-
-
0017333657
-
Morphological changes of the adipose cell plasma membrane during lipolysis
-
Carpentier J, Perrelet A, Orci, L. Morphological changes of the adipose cell plasma membrane during lipolysis. . Cell Biol 1977;72:104-117.
-
(1977)
J Cell Biol
, vol.72
, pp. 104-117
-
-
Carpentier, J.1
Perrelet, A.2
Orci, L.3
-
19
-
-
1242281221
-
Lipid-depleted white adipose cells: an electron microscope study
-
Napolitano L, Gagne H. Lipid-depleted white adipose cells: an electron microscope study. Anat Rec 1963;147:273-278.
-
(1963)
Anat Rec
, vol.147
, pp. 273-278
-
-
Napolitano, L.1
Gagne, H.2
-
20
-
-
0018193895
-
Vasodilatation and modulation of vasoconstriction in canine subcutaneous adipose tissue caused by activation of beta-adrenoceptors
-
Belfrage E. Vasodilatation and modulation of vasoconstriction in canine subcutaneous adipose tissue caused by activation of beta-adrenoceptors. Acta Physiol Scand 1978;102:459-468.
-
(1978)
Acta Physiol Scand
, vol.102
, pp. 459-468
-
-
Belfrage, E.1
-
21
-
-
0345900899
-
Paracrine regulation of angiogenesis and adipocyte differentiation during in vivo adipogenesis
-
Fukumura D, Ushiyama A, Duda DG, et al. Paracrine regulation of angiogenesis and adipocyte differentiation during in vivo adipogenesis. Circ Res 2003;93:88e-97.
-
(2003)
Circ Res
, vol.93
, pp. 88e-897
-
-
Fukumura, D.1
Ushiyama, A.2
Duda, D.G.3
-
22
-
-
0036678477
-
Adipose tissue mass can be regulated through the vasculature
-
Rupnick MA, Panigraphy D, Zhang CY, et al. Adipose tissue mass can be regulated through the vasculature. Proc Natl Acad Sci U S A 2002;99:10730-10735.
-
(2002)
Proc Natl Acad Sci U S A
, vol.99
, pp. 10730-10735
-
-
Rupnick, M.A.1
Panigraphy, D.2
Zhang, C.Y.3
-
23
-
-
3042786130
-
Angiogenesis inhibitor, TNP-470, prevents diet-induced and genetic obesity in mice
-
Brakenhielm E, Cao R, Gao B, et al. Angiogenesis inhibitor, TNP-470, prevents diet-induced and genetic obesity in mice. Circ Res 2004;94:1579-1588.
-
(2004)
Circ Res
, vol.94
, pp. 1579-1588
-
-
Brakenhielm, E.1
Cao, R.2
Gao, B.3
-
24
-
-
0345117960
-
Elevated serum vascular endothelial growth factor is associated with visceral fat accumulation in human obese subjects
-
Miyazawa-Hoshimoto S, Takahashi K, Bujo H, et al. Elevated serum vascular endothelial growth factor is associated with visceral fat accumulation in human obese subjects. Diabetologia 2003;46:1483-1438.
-
(2003)
Diabetologia
, vol.46
, pp. 1483-1438
-
-
Miyazawa-Hoshimoto, S.1
Takahashi, K.2
Bujo, H.3
-
25
-
-
0036173661
-
White adipocyte vascular endothelial growth factor regulation by insulin
-
Mick GJ, Wang X, McCormick K. White adipocyte vascular endothelial growth factor regulation by insulin. Endocrinology 2002;143:948-953.
-
(2002)
Endocrinology
, vol.143
, pp. 948-953
-
-
Mick, G.J.1
Wang, X.2
McCormick, K.3
-
26
-
-
2942703809
-
Reversal of obesity by targeted ablation of adipose tissue
-
Kolonin MG, Saha PK, Chan L, et al. Reversal of obesity by targeted ablation of adipose tissue. Nat Med 2004;10:625-632.
-
(2004)
Nat Med
, vol.10
, pp. 625-632
-
-
Kolonin, M.G.1
Saha, P.K.2
Chan, L.3
-
27
-
-
0347985272
-
Obesity-induced inflammatory changes in adipose tissue
-
Wellen KE, Hotamisligil GS. Obesity-induced inflammatory changes in adipose tissue. . Clin Invest 2003;112:1785-1788.
-
(2003)
J Clin Invest
, vol.112
, pp. 1785-1788
-
-
Wellen, K.E.1
Hotamisligil, G.S.2
-
28
-
-
0348230958
-
Obesity is associated with macrophase accumulation in adipose tissue
-
Weisberg SP, McCann D, Desai M, et al. Obesity is associated with macrophase accumulation in adipose tissue. . Clin Invest 2003;112:1796-1808.
-
(2003)
J Clin Invest
, vol.112
, pp. 1796-1808
-
-
Weisberg, S.P.1
McCann, D.2
Desai, M.3
-
29
-
-
9144223683
-
Chronic inflammation in fat plays a crucial role in the development of obesity-related insulin resistance
-
Xu H, Barnes GT, Yang Q, et al. Chronic inflammation in fat plays a crucial role in the development of obesity-related insulin resistance. . Clin Invest 2003;112:1821-1830.
-
(2003)
J Clin Invest
, vol.112
, pp. 1821-1830
-
-
Xu, H.1
Barnes, G.T.2
Yang, Q.3
-
30
-
-
0034903710
-
Prevention of fat-induced insulin resistance by salicylate
-
Kim JK, Kim YJ, Fillmore JJ, et al. Prevention of fat-induced insulin resistance by salicylate. . Clin Invest 2001;108:437-446.
-
(2001)
J Clin Invest
, vol.108
, pp. 437-446
-
-
Kim, J.K.1
Kim, Y.J.2
Fillmore, J.J.3
-
31
-
-
0003851178
-
-
New York: American Elsevier Publishing
-
Lindberg O. Brown adipose tissue. New York: American Elsevier Publishing, 1970.
-
(1970)
Brown adipose tissue.
-
-
Lindberg, O.1
-
32
-
-
0000426810
-
Thermogenic activity of the hibernating gland in the cold-acclimated rat
-
Smith R. Thermogenic activity of the hibernating gland in the cold-acclimated rat. Physiologist 1961;4:113.
-
(1961)
Physiologist
, vol.4
, pp. 113
-
-
Smith, R.1
-
33
-
-
0000446201
-
On the action of hormones which accelerate the rate of oxygen consumption and fatty acid release in rat adipose tissue
-
Ball E, Jungas R. On the action of hormones which accelerate the rate of oxygen consumption and fatty acid release in rat adipose tissue in vitro. Proc Natl Acad Sci U S A 1961;47:932-941.
-
(1961)
in vitro. Proc Natl Acad Sci U S A
, vol.47
, pp. 932-941
-
-
Ball, E.1
Jungas, R.2
-
34
-
-
0000143140
-
Brown adipose tissue hyperplasia: a fundamental mechanism of adaptation to a cold and hyperphagia
-
Bukowiecki L, Collet A, Follea N, et al. Brown adipose tissue hyperplasia: a fundamental mechanism of adaptation to a cold and hyperphagia. Am J Physiol 1982;242:E353-E359.
-
(1982)
Am J Physiol
, vol.242
, pp. E353-E359
-
-
Bukowiecki, L.1
Collet, A.2
Follea, N.3
-
35
-
-
0027055792
-
Role of sympathetic innervation in brown adipocyte proliferation
-
Góloën A, Collet AJ, Bukowiecki LJ. Role of sympathetic innervation in brown adipocyte proliferation. Am J Physiol 1992;263:R1176-R1181.
-
(1992)
Am J Physiol
, vol.263
, pp. R1176-R1181
-
-
Góloën, A.1
Collet, A.J.2
Bukowiecki, L.J.3
-
36
-
-
0017391789
-
The regulation of the biological furnace of warm blooded animals
-
Girardier L. The regulation of the biological furnace of warm blooded animals. Experientia 1977;33:1121-1131.
-
(1977)
Experientia
, vol.33
, pp. 1121-1131
-
-
Girardier, L.1
-
37
-
-
0020359244
-
Exclusive occurrence of thermogenin antigen in brown adipose tissue
-
Cannon, B, Hedin A, Nedergaard J. Exclusive occurrence of thermogenin antigen in brown adipose tissue. FEBS Lett 1982;150:129-132.
-
(1982)
FEBS Lett
, vol.150
, pp. 129-132
-
-
Cannon, B.1
Hedin, A.2
Nedergaard, J.3
-
38
-
-
0034668852
-
Mitochondrial uncoupling proteins: from mitochondria to the regulation of energy balance
-
Ricquier D, Bouillaud F. Mitochondrial uncoupling proteins: from mitochondria to the regulation of energy balance. . Physiol 2000;529(Pt 1):3-10.
-
(2000)
J Physiol
, vol.529
, pp. 3-10
-
-
Ricquier, D.1
Bouillaud, F.2
-
39
-
-
0016042975
-
Growth and distribution of human fetal brown fat
-
Merklin RJ. Growth and distribution of human fetal brown fat. Anat Rec 1974;178:637-645.
-
(1974)
Anat Rec
, vol.178
, pp. 637-645
-
-
Merklin, R.J.1
-
40
-
-
0035787319
-
The D-adrenergic receptors and the control of adipose tissue metabolism and thermogenesis. In: Means AR, ed
-
Bethesda, MD: Endocrine Society Press
-
Collins S, Surwit RS. The D-adrenergic receptors and the control of adipose tissue metabolism and thermogenesis. In: Means AR, ed. Recent progress in hormone research. Bethesda, MD: Endocrine Society Press, 2001:309-328.
-
(2001)
Recent progress in hormone research.
, pp. 309-328
-
-
Collins, S.1
Surwit, R.S.2
-
41
-
-
0022482362
-
Brown adipose tissue in patients with phaeochromocytoma
-
Lean ME, James WP, Jennings G, et al. Brown adipose tissue in patients with phaeochromocytoma. Int J Obes 1986;10:219-227.
-
(1986)
Int J Obes
, vol.10
, pp. 219-227
-
-
Lean, M.E.1
James, W.P.2
Jennings, G.3
-
42
-
-
0016292538
-
Postnatal development of adipocyte cellularity in the normal rat
-
Greenwood MR, Hirsch J. Postnatal development of adipocyte cellularity in the normal rat. . Lipid Res 1974;15:474-483.
-
(1974)
J Lipid Res
, vol.15
, pp. 474-483
-
-
Greenwood, M.R.1
Hirsch, J.2
-
43
-
-
0020955532
-
Cellular and vascular development in immature rat adipose tissue
-
Hausman GJ, Richardson RL. Cellular and vascular development in immature rat adipose tissue. . Lipid Res 1983;24:522-532.
-
(1983)
J Lipid Res
, vol.24
, pp. 522-532
-
-
Hausman, G.J.1
Richardson, R.L.2
-
44
-
-
0034214246
-
Transcriptional regulation of adipogenesis
-
Rosen ED, Walkey CJ, Puigserver P, et al. Transcriptional regulation of adipogenesis. Genes Dev 2000;14:1293-1307.
-
(2000)
Genes Dev
, vol.14
, pp. 1293-1307
-
-
Rosen, E.D.1
Walkey, C.J.2
Puigserver, P.3
-
45
-
-
0029065480
-
Differential effects of fat and sucrose on the development of obesity and diabetes in C57BL/6J and A/J mice
-
Surwit RS, Feinglos MN, Rodin J, et al. Differential effects of fat and sucrose on the development of obesity and diabetes in C57BL/6J and A/J mice. Metabolism 1995;44:645-651.
-
(1995)
Metabolism
, vol.44
, pp. 645-651
-
-
Surwit, R.S.1
Feinglos, M.N.2
Rodin, J.3
-
46
-
-
12144291563
-
Peroxisome proliferator-activated receptor gamma is required in mature white and brown adipocytes for their survival in the mouse
-
Imai T, Takakuwa R, Marchand S, et al. Peroxisome proliferator-activated receptor gamma is required in mature white and brown adipocytes for their survival in the mouse. Proc Natl Acad Sci U S A 2004;101:4543-4547.
-
(2004)
Proc Natl Acad Sci U S A
, vol.101
, pp. 4543-4547
-
-
Imai, T.1
Takakuwa, R.2
Marchand, S.3
-
47
-
-
0016243979
-
Sublines of mouse 3T3 cells that accumulate lipid
-
Green H, Kehinde O. Sublines of mouse 3T3 cells that accumulate lipid. Cell 1974;1:113-116.
-
(1974)
Cell
, vol.1
, pp. 113-116
-
-
Green, H.1
Kehinde, O.2
-
48
-
-
0033251387
-
Insights into the transcriptional control of adipocyte differentiation
-
Morrison RF, Farmer SR. Insights into the transcriptional control of adipocyte differentiation. . Cell Biochem 1999[Suppl 32-33]:59-67.
-
(1999)
J Cell Biochem
, pp. 59-67
-
-
Morrison, R.F.1
Farmer, S.R.2
-
49
-
-
0028641559
-
Stimulation of adipogenesis in fibroblasts by PPAR gamma2, a lipid-activated factor
-
Tontonoz P, Hu E, Spiegelman BM. Stimulation of adipogenesis in fibroblasts by PPAR gamma2, a lipid-activated factor. Cell 1994;79:1147-1156.
-
(1994)
Cell
, vol.79
, pp. 1147-1156
-
-
Tontonoz, P.1
Hu, E.2
Spiegelman, B.M.3
-
50
-
-
0033083803
-
Cross-regulation of C/EBPα and PPARγ controls the transcriptional pathway of adipogenesis and insulin sensitivity
-
Wu Z, Rosen ED, Brun R, et al. Cross-regulation of C/EBPα and PPARγ controls the transcriptional pathway of adipogenesis and insulin sensitivity. Mol Cell 1999;3:151-158.
-
(1999)
Mol Cell
, vol.3
, pp. 151-158
-
-
Wu, Z.1
Rosen, E.D.2
Brun, R.3
-
51
-
-
0032801844
-
Role of PPAR gamma in regulating adipocyte differentiation and insulin-responsive glucose uptake
-
Hamm JK, el Jack AK, Pilch PF, et al. Role of PPAR gamma in regulating adipocyte differentiation and insulin-responsive glucose uptake. Ann N Y Acad Sci 1999;892:134-145.
-
(1999)
Ann N Y Acad Sci
, vol.892
, pp. 134-145
-
-
Hamm, J.K.1
el Jack, A.K.2
Pilch, P.F.3
-
52
-
-
0035808331
-
CAATT/enhancer binding protein-α is required for transcription of the D3AR gene during adipogenesis
-
Dixon TM, Daniel KW, Farmer SR, et al. CAATT/enhancer binding protein-α is required for transcription of the D3AR gene during adipogenesis. Biol Chem 2001;276:722-728.
-
(2001)
J Biol Chem
, vol.276
, pp. 722-728
-
-
Dixon, T.M.1
Daniel, K.W.2
Farmer, S.R.3
-
53
-
-
0028180070
-
mPPAR2: tissue-specific regulator of an adipocyte enhancer
-
Tontonoz P, Hu E, Graves RA, et al. mPPAR2: tissue-specific regulator of an adipocyte enhancer. Genes Dev 1994;8:1224-1234.
-
(1994)
Genes Dev
, vol.8
, pp. 1224-1234
-
-
Tontonoz, P.1
Hu, E.2
Graves, R.A.3
-
54
-
-
0028321529
-
Differential expression and activation of a family of murine peroxisome proliferator-activates receptors
-
Kliewer SA, Forman BM, Blumberg B, et al. Differential expression and activation of a family of murine peroxisome proliferator-activates receptors. Proc Natl Acad Sci U S A 1994;91:7355-7359.
-
(1994)
Proc Natl Acad Sci U S A
, vol.91
, pp. 7355-7359
-
-
Kliewer, S.A.1
Forman, B.M.2
Blumberg, B.3
-
55
-
-
1842279106
-
Expression of specific mRNAs during adipose differentiation: identification of an mRNA encoding a homologue of myelin P2 protein
-
Bernlohr DA, Angus CW, Lane MD, et al. Expression of specific mRNAs during adipose differentiation: identification of an mRNA encoding a homologue of myelin P2 protein. Proc Natl Acad Sci U S A 1984;81:5468-5472.
-
(1984)
Proc Natl Acad Sci U S A
, vol.81
, pp. 5468-5472
-
-
Bernlohr, D.A.1
Angus, C.W.2
Lane, M.D.3
-
56
-
-
0026080933
-
Identification of a potent adipocyte-specific enhancer: involvement of an NF-1-like factor
-
Graves RA, Tontonoz P, Ross SR, et al. Identification of a potent adipocyte-specific enhancer: involvement of an NF-1-like factor. Genes Dev 1991;5:428-437.
-
(1991)
Genes Dev
, vol.5
, pp. 428-437
-
-
Graves, R.A.1
Tontonoz, P.2
Ross, S.R.3
-
57
-
-
0026525053
-
Analysis of a tissue-specific enhancer: ARF6 regulates adipogenic gene expression
-
Graves RA, Tontonoz P, Spiegelman BM. Analysis of a tissue-specific enhancer: ARF6 regulates adipogenic gene expression. Mol Cell Biol 1992;12: 1202-1208.
-
(1992)
Mol Cell Biol
, vol.12
, pp. 1202-1208
-
-
Graves, R.A.1
Tontonoz, P.2
Spiegelman, B.M.3
-
58
-
-
0033213631
-
PPAR gamma is required for the differentiation of adipose tissue in vivo and in vitro
-
Rosen ED, Sarraf P, Troy AE, et al. PPAR gamma is required for the differentiation of adipose tissue in vivo and in vitro. Mol Cell 1999;4:611-617.
-
(1999)
Mol Cell
, vol.4
, pp. 611-617
-
-
Rosen, E.D.1
Sarraf, P.2
Troy, A.E.3
-
59
-
-
3242720242
-
Selective disruption of PPARgamma 2 impairs the development of adipose tissue and insulin sensitivity
-
Zhang J, Fu M, Cui T, et al. Selective disruption of PPARgamma 2 impairs the development of adipose tissue and insulin sensitivity. Proc Natl Acad Sci U S A 2004;101:10703-10708.
-
(2004)
Proc Natl Acad Sci U S A
, vol.101
, pp. 10703-10708
-
-
Zhang, J.1
Fu, M.2
Cui, T.3
-
60
-
-
0036007024
-
C/EBPalpha induces adipogenesis through PPARgamma: a unified pathway
-
Rosen ED, Hsu CH, Wang X, et al. C/EBPalpha induces adipogenesis through PPARgamma: a unified pathway. Genes Dev 2002;16:22-26.
-
(2002)
Genes Dev
, vol.16
, pp. 22-26
-
-
Rosen, E.D.1
Hsu, C.H.2
Wang, X.3
-
61
-
-
0036007025
-
PPARgamma knockdown by engineered transcription factors: exogenous PPARgamma2 but not PPARgamma1 reactivates adipogenesis
-
Ren D, Collingwood TN, Rebar EJ, et al. PPARgamma knockdown by engineered transcription factors: exogenous PPARgamma2 but not PPARgamma1 reactivates adipogenesis. Genes Dev 2002;16:27-32.
-
(2002)
Genes Dev
, vol.16
, pp. 27-32
-
-
Ren, D.1
Collingwood, T.N.2
Rebar, E.J.3
-
62
-
-
0033105510
-
Molecular recognition of fatty acids by peroxisome proliferator-activated receptors
-
Xu HE, Lambert MH, Montana VG, et al. Molecular recognition of fatty acids by peroxisome proliferator-activated receptors. Mol Cell 1999;3:397-403.
-
(1999)
Mol Cell
, vol.3
, pp. 397-403
-
-
Xu, H.E.1
Lambert, M.H.2
Montana, V.G.3
-
63
-
-
0032611495
-
Metabolism of xenobiotics and chemical carcinogenesis
-
Lang M, Pelkonen O. Metabolism of xenobiotics and chemical carcinogenesis. IARC Sci Publ; 1999:13-22.
-
(1999)
IARC Sci Publ
, pp. 13-22
-
-
Lang, M.1
Pelkonen, O.2
-
64
-
-
0035940360
-
C/EBPalpha is required for differentiation of white, but not brown, adipose tissue
-
Linhart HG, Ishimura-Oka K, DeMayo F, et al. C/EBPalpha is required for differentiation of white, but not brown, adipose tissue. Proc Natl Acad Sci U S A 2001;98:12532-12537.
-
(2001)
Proc Natl Acad Sci U S A
, vol.98
, pp. 12532-12537
-
-
Linhart, H.G.1
Ishimura-Oka, K.2
DeMayo, F.3
-
65
-
-
0033212964
-
PPAR gamma mediates high-fat dietinduced adipocyte hypertrophy and insulin resistance
-
Kubota N, Terauchi Y, Miki H, et al. PPAR gamma mediates high-fat dietinduced adipocyte hypertrophy and insulin resistance. Mol Cell 1999;4:597-609.
-
(1999)
Mol Cell
, vol.4
, pp. 597-609
-
-
Kubota, N.1
Terauchi, Y.2
Miki, H.3
-
66
-
-
0033213637
-
PPAR gamma is required for placental, cardiac, and adipose tissue development
-
Barak Y, Nelson MC, Ong ES, et al. PPAR gamma is required for placental, cardiac, and adipose tissue development. Mol Cell 1999;4:585-595.
-
(1999)
Mol Cell
, vol.4
, pp. 585-595
-
-
Barak, Y.1
Nelson, M.C.2
Ong, E.S.3
-
67
-
-
9144229185
-
Adipose-specific peroxisome proliferatoractivated receptor gamma knockout causes insulin resistance in fat and liver but not in muscle
-
He W, Barak Y, Hevener A, et al. Adipose-specific peroxisome proliferatoractivated receptor gamma knockout causes insulin resistance in fat and liver but not in muscle. Proc Natl Acad Sci U S A 2003;100:15712-15717.
-
(2003)
Proc Natl Acad Sci U S A
, vol.100
, pp. 15712-15717
-
-
He, W.1
Barak, Y.2
Hevener, A.3
-
68
-
-
0026778277
-
Adrenergic regulation of the mitochondrial uncoupling protein gene in brown fat tumor cells
-
Kozak UC, Held W, Kreutter D, et al. Adrenergic regulation of the mitochondrial uncoupling protein gene in brown fat tumor cells. Mol Endocrinol 1992; 6:763-772.
-
(1992)
Mol Endocrinol
, vol.6
, pp. 763-772
-
-
Kozak, U.C.1
Held, W.2
Kreutter, D.3
-
69
-
-
0027982813
-
Norepinephrine-dependent selection of brown adipocyte cell lines
-
Kozak UC, Kozak LP. Norepinephrine-dependent selection of brown adipocyte cell lines. Endocrinology 1994;134:906-913.
-
(1994)
Endocrinology
, vol.134
, pp. 906-913
-
-
Kozak, U.C.1
Kozak, L.P.2
-
70
-
-
0026655613
-
Hibernoma formation in transgenic mice and isolation of a brown adipocyte cell line expressing the uncoupling protein gene
-
Ross SR, Choy L, Graves RA, et al. Hibernoma formation in transgenic mice and isolation of a brown adipocyte cell line expressing the uncoupling protein gene. Proc Natl Acad Sci U S A 1992;89:7561-7565.
-
(1992)
Proc Natl Acad Sci U S A
, vol.89
, pp. 7561-7565
-
-
Ross, S.R.1
Choy, L.2
Graves, R.A.3
-
71
-
-
0033574032
-
Immortal brown adipocytes from p53-knockout mice: differentiation and expression of uncoupling proteins
-
Irie Y, Asano A, Canas X, et al. Immortal brown adipocytes from p53-knockout mice: differentiation and expression of uncoupling proteins. Biochem Biophys Res Commun 1999;255:221-225.
-
(1999)
Biochem Biophys Res Commun
, vol.255
, pp. 221-225
-
-
Irie, Y.1
Asano, A.2
Canas, X.3
-
72
-
-
0028935963
-
Regulation of the uncoupling protein gene (Ucp) by D1, D2, D3-adrenergic subtypes in immortalized brown adipose cell lines
-
Rohlfs EM, Daniel KW, Premont RT, et al. Regulation of the uncoupling protein gene (Ucp) by D1, D2, D3-adrenergic subtypes in immortalized brown adipose cell lines. . Biol Chem 1995;270:10723-10732.
-
(1995)
J Biol Chem
, vol.270
, pp. 10723-10732
-
-
Rohlfs, E.M.1
Daniel, K.W.2
Premont, R.T.3
-
73
-
-
0035168994
-
Gene expression in visceral and subcutaneous adipose tissues
-
Vidal H. Gene expression in visceral and subcutaneous adipose tissues. Ann Med 2001;33:547-555.
-
(2001)
Ann Med
, vol.33
, pp. 547-555
-
-
Vidal, H.1
-
74
-
-
0021112422
-
Molecular cloning of mRNA from 3T3 adipocytes. Regulation of mRNA content for glycerophosphate dehydrogenase and other differentiation-dependent proteins during adipocyte development
-
Spiegelman BM, Frank M, Green H. Molecular cloning of mRNA from 3T3 adipocytes. Regulation of mRNA content for glycerophosphate dehydrogenase and other differentiation-dependent proteins during adipocyte development. . Biol Chem 1983;258:10083-10089.
-
(1983)
J Biol Chem
, vol.258
, pp. 10083-10089
-
-
Spiegelman, B.M.1
Frank, M.2
Green, H.3
-
75
-
-
0032549811
-
A cold-inducible coactivator of nuclear receptors linked to adaptive thermogenesis
-
Puigserver P, Wu Z, Park C, et al. A cold-inducible coactivator of nuclear receptors linked to adaptive thermogenesis. Cell 1998;92:829-839.
-
(1998)
Cell
, vol.92
, pp. 829-839
-
-
Puigserver, P.1
Wu, Z.2
Park, C.3
-
76
-
-
0033538473
-
Mechanisms controlling mitochondrial biogenesis and respiration through the thermogenic coactivator PGC-1
-
Wu Z, Puigserver P, Andersson U, et al. Mechanisms controlling mitochondrial biogenesis and respiration through the thermogenic coactivator PGC-1. Cell 1999;98:115-124.
-
(1999)
Cell
, vol.98
, pp. 115-124
-
-
Wu, Z.1
Puigserver, P.2
Andersson, U.3
-
77
-
-
1642293248
-
p38 mitogen-activated protein kinase is the central regulator of cyclic AMP-dependent transcription of the brown fat uncoupling protein 1 gene
-
Cao W, Daniel KW, Robidoux J, et al. p38 mitogen-activated protein kinase is the central regulator of cyclic AMP-dependent transcription of the brown fat uncoupling protein 1 gene. Mol Cell Biol 2004;24:3057-3067.
-
(2004)
Mol Cell Biol
, vol.24
, pp. 3057-3067
-
-
Cao, W.1
Daniel, K.W.2
Robidoux, J.3
-
78
-
-
84958689411
-
The role of depot fat in the hypothalamic control of food intake in the rat
-
Kennedy GL. The role of depot fat in the hypothalamic control of food intake in the rat. Proc R Soc Lond 1953;140:579-592.
-
(1953)
Proc R Soc Lond
, vol.140
, pp. 579-592
-
-
Kennedy, G.L.1
-
79
-
-
0032558725
-
Leptin and the regulation of body weight in mammals
-
Friedman JM, Halaas JL. Leptin and the regulation of body weight in mammals. Nature 1998;395:763-770.
-
(1998)
Nature
, vol.395
, pp. 763-770
-
-
Friedman, J.M.1
Halaas, J.L.2
-
80
-
-
0014608866
-
Effects of parabiosis of normal with genetically diabetic mice
-
Coleman DL, Hummel KP. Effects of parabiosis of normal with genetically diabetic mice. Am J Physiol 1969;217:1298-1304.
-
(1969)
Am J Physiol
, vol.217
, pp. 1298-1304
-
-
Coleman, D.L.1
Hummel, K.P.2
-
81
-
-
0015792424
-
Effects of parabiosis of obese with diabetes and normal mice
-
Coleman DL. Effects of parabiosis of obese with diabetes and normal mice Diabetologia 1973;9:294-298.
-
(1973)
Diabetologia
, vol.9
, pp. 294-298
-
-
Coleman, D.L.1
-
82
-
-
2442654859
-
Identification and expression cloning of a leptin receptor, OB-R
-
Tartaglia LA, Dembski M, Weng X, et al. Identification and expression cloning of a leptin receptor, OB-R. Cell 1995;83:1263-1271.
-
(1995)
Cell
, vol.83
, pp. 1263-1271
-
-
Tartaglia, L.A.1
Dembski, M.2
Weng, X.3
-
83
-
-
0030039272
-
Abnormal splicing of the leptin receptor in diabetic mice
-
Lee G-H, Proenca R, Montez JM, et al. Abnormal splicing of the leptin receptor in diabetic mice. Nature 1996;379:632-635.
-
(1996)
Nature
, vol.379
, pp. 632-635
-
-
Lee, G.-H.1
Proenca, R.2
Montez, J.M.3
-
85
-
-
0031760170
-
Evidence that glucose metabolism regulates leptin secretion from cultured rat adipocytes
-
Mueller WM, Gregoire FM, Stanhope KL, et al. Evidence that glucose metabolism regulates leptin secretion from cultured rat adipocytes. Endocrinology 1998;139:551-558.
-
(1998)
Endocrinology
, vol.139
, pp. 551-558
-
-
Mueller, W.M.1
Gregoire, F.M.2
Stanhope, K.L.3
-
86
-
-
0032543680
-
A nutrient-sensing pathway regulates leptin gene expression in muscle and fat
-
Wang J, Liu R, Hawkins M, et al. A nutrient-sensing pathway regulates leptin gene expression in muscle and fat. Nature 1998;393:684-688.
-
(1998)
Nature
, vol.393
, pp. 684-688
-
-
Wang, J.1
Liu, R.2
Hawkins, M.3
-
87
-
-
0036068133
-
Adipose tissue selective insulin receptor protects against obesity and obesity-related glucose intolerance
-
Bluher M, Michael MD, Peroni OK, et al. Adipose tissue selective insulin receptor protects against obesity and obesity-related glucose intolerance. Dev Cell 2002;3:25-38.
-
(2002)
Dev Cell
, vol.3
, pp. 25-38
-
-
Bluher, M.1
Michael, M.D.2
Peroni, O.K.3
-
88
-
-
0029066265
-
Effects of the obese gene product on body weight regulation in obob mice
-
Pelleymounter MA, Cullen MJ, Baker MB, et al. Effects of the obese gene product on body weight regulation in obob mice. Science 1995;269:540-543.
-
(1995)
Science
, vol.269
, pp. 540-543
-
-
Pelleymounter, M.A.1
Cullen, M.J.2
Baker, M.B.3
-
89
-
-
0029073613
-
Weight-reducing effects of the plasma protein encoded by the obese gene
-
Halaas JL, Gajiwala KS, Maffei M, et al. Weight-reducing effects of the plasma protein encoded by the obese gene. Science 1995;269:543-546.
-
(1995)
Science
, vol.269
, pp. 543-546
-
-
Halaas, J.L.1
Gajiwala, K.S.2
Maffei, M.3
-
90
-
-
0029048408
-
Recombinant mouse OB protein: evidence for a peripheral signal linking adiposity and central neural networks
-
Campfield LA, Smith FJ, Guisez Y, et al. Recombinant mouse OB protein: evidence for a peripheral signal linking adiposity and central neural networks. Science 1995;269:546-549.
-
(1995)
Science
, vol.269
, pp. 546-549
-
-
Campfield, L.A.1
Smith, F.J.2
Guisez, Y.3
-
91
-
-
15844409555
-
Role of leptin in fat regulation
-
Collins S, Kuhn CM, Petro AE, et al. Role of leptin in fat regulation. Nature 1996;380:677.
-
(1996)
Nature
, vol.380
, pp. 677
-
-
Collins, S.1
Kuhn, C.M.2
Petro, A.E.3
-
92
-
-
0032713705
-
Sympathetic inhibition, leptin, and uncoupling protein subtype expression in normal fasting rats
-
Sivitz WI, Fink BD, Morgan DA, et al. Sympathetic inhibition, leptin, and uncoupling protein subtype expression in normal fasting rats. Am J Physiol 1999;277:E668-677.
-
(1999)
Am J Physiol
, vol.277
, pp. E668-E677
-
-
Sivitz, W.I.1
Fink, B.D.2
Morgan, D.A.3
-
93
-
-
0033082380
-
From lesions to leptin: hypothalamic control of food intake and body weight
-
Elmquist JK, Elias CF, Saper CB. From lesions to leptin: hypothalamic control of food intake and body weight. Neuron 1999;22:221-232.
-
(1999)
Neuron
, vol.22
, pp. 221-232
-
-
Elmquist, J.K.1
Elias, C.F.2
Saper, C.B.3
-
94
-
-
0035970842
-
Virus-assisted mapping of neural inputs to a feeding center in the hypothalamus
-
DeFalco J, Tomishima M, Liu H, et al. Virus-assisted mapping of neural inputs to a feeding center in the hypothalamus. Science 2001;291:2608-2613.
-
(2001)
Science
, vol.291
, pp. 2608-2613
-
-
DeFalco, J.1
Tomishima, M.2
Liu, H.3
-
95
-
-
0035757975
-
Brain pathways controlling food intake and body weight
-
(Maywood)
-
Schwartz MW. Brain pathways controlling food intake and body weight. Exp Biol Med (Maywood) 2001;226:978-981.
-
(2001)
Exp Biol Med
, vol.226
, pp. 978-981
-
-
Schwartz, M.W.1
-
96
-
-
0030942844
-
The leptin receptor
-
Tartaglia LA. The leptin receptor. . Biol Chem 1997;272:6093-6096.
-
(1997)
J Biol Chem
, vol.272
, pp. 6093-6096
-
-
Tartaglia, L.A.1
-
97
-
-
0032014178
-
Identification of SOCS-3 as a potential mediator of central leptin resistance
-
Bjorbaek C, Elmquist JK, Frantz JD, et al. Identification of SOCS-3 as a potential mediator of central leptin resistance. Mol Cell 1998;1:619-625.
-
(1998)
Mol Cell
, vol.1
, pp. 619-625
-
-
Bjorbaek, C.1
Elmquist, J.K.2
Frantz, J.D.3
-
98
-
-
0035851907
-
Hypothalamic pathways underlying the endocrine, autonomic, and behavioral effects of leptin
-
Elmquist JK. Hypothalamic pathways underlying the endocrine, autonomic, and behavioral effects of leptin. Physiol Behav 2001;74:703-708.
-
(2001)
Physiol Behav
, vol.74
, pp. 703-708
-
-
Elmquist, J.K.1
-
99
-
-
0035950093
-
Intracellular signalling. Key enzyme in leptin-induced anorexia
-
Niswender KD, Morton GJ, Stearns WH, et al. Intracellular signalling. Key enzyme in leptin-induced anorexia. Nature 2001;413:794-795.
-
(2001)
Nature
, vol.413
, pp. 794-795
-
-
Niswender, K.D.1
Morton, G.J.2
Stearns, W.H.3
-
100
-
-
0036913187
-
Hypothalamic insulin signaling is required for inhibition of glucose production Nat Med 2002;8:1376-1382. 100a. Minokoshi Y, Kim YB, Peroni OD, et al. Leptin stimulates fatty-acid oxidation by activating AMP-activated protein kinase
-
Obici S, Zhang BB, Karkanias G, et al. Hypothalamic insulin signaling is required for inhibition of glucose production Nat Med 2002;8:1376-1382. 100a. Minokoshi Y, Kim YB, Peroni OD, et al. Leptin stimulates fatty-acid oxidation by activating AMP-activated protein kinase. Nature 2002;415:339-343. 100b. Andersson U, Filipsson K, Abbott CR, et al. AMP-activated protein kinase plays a role in the control of food intake. . Biol Chem 2004;279:12005-12008. 100c. Minokoshi Y, Alquier T, Furukawa N, et al. AMP-kinase regulates food intake by responding to hormonal and nutrient signals in the hypothalamus. Nature 2004;428:569-574.
-
(2004)
Nature 2002;415:339-343. 100b. Andersson U, Filipsson K, Abbott CR, et al. AMP-activated protein kinase plays a role in the control of food intake. . Biol Chem 2004;279:12005-12008. 100c. Minokoshi Y, Alquier T, Furukawa N, et al. AMP-kinase regulates food intake by responding to hormonal and nutrient signals in the hypothalamus. Nature
, vol.428
, pp. 569-574
-
-
Obici, S.1
Zhang, B.B.2
Karkanias, G.3
-
102
-
-
0029896530
-
Role of leptin in the neuroendocrine response to fasting
-
Ahima RS, Prabakaran D, Mantzoros C, et al. Role of leptin in the neuroendocrine response to fasting. Nature 1996;382:250-252.
-
(1996)
Nature
, vol.382
, pp. 250-252
-
-
Ahima, R.S.1
Prabakaran, D.2
Mantzoros, C.3
-
103
-
-
0036800760
-
Beneficial effects of leptin on obesity, T cell hyporesponsiveness, and neuroendocrine dysfunction of human congenital leptin deficiency
-
Farooqi IS, Matarese G, Lord GM, et al. Beneficial effects of leptin on obesity, T cell hyporesponsiveness, and neuroendocrine dysfunction of human congenital leptin deficiency. . Clin Invest 2002;110:1093-2003.
-
(2002)
J Clin Invest
, vol.110
, pp. 1093-2003
-
-
Farooqi, I.S.1
Matarese, G.2
Lord, G.M.3
-
104
-
-
0034776770
-
Selective deletion of leptin receptor in neurons leads to obesity
-
Cohen P, Zhao C, Cai X, et al. Selective deletion of leptin receptor in neurons leads to obesity. . Clin Invest 2001;108:1113-1121.
-
(2000)
J Clin Invest 2001;108:1113-1121. 104a. El-Haschimi K, Pierroz DD, Hileman SM, et al. Two defects contribute to hypothalamic leptin resistance in mice with diet-induced obesity. . Clin Invest
, vol.105
, pp. 1827-1832 104b
-
-
Cohen, P.1
Zhao, C.2
Cai, X.3
-
105
-
-
9244219587
-
Region-specific leptin resistance within the hypothalamus of diet-induced obese mice
-
Jul 22
-
Munzberg H, Flier JS, Bjorbaek C. Region-specific leptin resistance within the hypothalamus of diet-induced obese mice. Endocrinology 2004;Jul 22.
-
(2004)
Endocrinology
-
-
Munzberg, H.1
Flier, J.S.2
Bjorbaek, C.3
-
106
-
-
0037456304
-
STAT3 signalling is required for leptin regulation of energy balance but not reproduction
-
Bates SH, Stearns WH, Dundon TA, et al. STAT3 signalling is required for leptin regulation of energy balance but not reproduction. Nature 2003;421: 856-859.
-
(2003)
Nature
, vol.421
, pp. 856-859
-
-
Bates, S.H.1
Stearns, W.H.2
Dundon, T.A.3
-
107
-
-
1842584949
-
Disruption of neural signal transducer and activator of transcription 3 causes obesity, diabetes, infertility, and thermal dysregulation
-
Gao Q, Wolfgang MJ, Neschen S, et al. Disruption of neural signal transducer and activator of transcription 3 causes obesity, diabetes, infertility, and thermal dysregulation. Proc Natl Acad Sci U S A 2004;101:4661-4666.
-
(2004)
Proc Natl Acad Sci U S A
, vol.101
, pp. 4661-4666
-
-
Gao, Q.1
Wolfgang, M.J.2
Neschen, S.3
-
108
-
-
3142723983
-
Socs3 deficiency in the brain elevates leptin sensitivity and confers resistance to diet-induced obesity
-
Mori H, Hanada R, Hanada T, et al. Socs3 deficiency in the brain elevates leptin sensitivity and confers resistance to diet-induced obesity. Nat Med 2004; 10:739-743.
-
(2004)
Nat Med
, vol.10
, pp. 739-743
-
-
Mori, H.1
Hanada, R.2
Hanada, T.3
-
109
-
-
3142782772
-
Enhanced leptin sensitivity and attenuation of diet-induced obesity in mice with haploinsufficiency of Socs3
-
Howard JK, Cave BJ, Oksanen LJ, et al. Enhanced leptin sensitivity and attenuation of diet-induced obesity in mice with haploinsufficiency of Socs3. Nat Med 2004;10:734-738.
-
(2004)
Nat Med
, vol.10
, pp. 734-738
-
-
Howard, J.K.1
Cave, B.J.2
Oksanen, L.J.3
-
110
-
-
0031050415
-
Relatively low plasma leptin concentrations precede weight gain in Pima Indians
-
Ravussin E, Pratley RE, Maffei M, et al. Relatively low plasma leptin concentrations precede weight gain in Pima Indians. Nat Med 1997;3:238-240.
-
(1997)
Nat Med
, vol.3
, pp. 238-240
-
-
Ravussin, E.1
Pratley, R.E.2
Maffei, M.3
-
111
-
-
0030804112
-
Low plasma leptin in response to dietary fat in diabetes-and obesity-prone mice
-
Surwit R, Petro A, Parekh P, et al. Low plasma leptin in response to dietary fat in diabetes-and obesity-prone mice. Diabetes 1997;46:1516-1520.
-
(1997)
Diabetes
, vol.46
, pp. 1516-1520
-
-
Surwit, R.1
Petro, A.2
Parekh, P.3
-
112
-
-
0031785868
-
Is a low leptin concentration, a low resting metabolic rate, or both the expression of the "thrifty genotype"? Results from Mexican Pima Indians
-
Fox CS, Esparza J, Nicolson M, et al. Is a low leptin concentration, a low resting metabolic rate, or both the expression of the "thrifty genotype"? Results from Mexican Pima Indians. Am J Clin Nutr 1998;68:1053-1057.
-
(1998)
Am J Clin Nutr
, vol.68
, pp. 1053-1057
-
-
Fox, C.S.1
Esparza, J.2
Nicolson, M.3
-
113
-
-
0033921914
-
Transient effects of long-term leptin supplementation in the prevention of diet-induced obesity in mice
-
Surwit RS, Edwards CL, Murthy S, et al. Transient effects of long-term leptin supplementation in the prevention of diet-induced obesity in mice. Diabetes 2000;49:1203-1208.
-
(2000)
Diabetes
, vol.49
, pp. 1203-1208
-
-
Surwit, R.S.1
Edwards, C.L.2
Murthy, S.3
-
114
-
-
0036093071
-
Low dose leptin administration reverses effects of sustained weight-reduction on energy expenditure and circulating concentrations of thryoid hormoes
-
Rosenbaum M, Murphy EM, Heymsfield SB, et al. Low dose leptin administration reverses effects of sustained weight-reduction on energy expenditure and circulating concentrations of thryoid hormoes. . Clin Endocrinol Metab 2002;87:2391-2394.
-
(2002)
J Clin Endocrinol Metab
, vol.87
, pp. 2391-2394
-
-
Rosenbaum, M.1
Murphy, E.M.2
Heymsfield, S.B.3
-
115
-
-
0037651108
-
The role of falling leptin levels in the neuroendocrine and metabolic adaptation to short-term starvation in healthy men
-
Chan JL, Heist K, DePaoli AM, et al. The role of falling leptin levels in the neuroendocrine and metabolic adaptation to short-term starvation in healthy men. . Clin Invest 2003;111:1409-1421.
-
(2003)
J Clin Invest
, vol.111
, pp. 1409-1421
-
-
Chan, J.L.1
Heist, K.2
DePaoli, A.M.3
-
116
-
-
0031025130
-
Hypoleptinemia in women athletes: absence of a diurnal rhythm with amenorrhea
-
Laughlin GA, Yen SS. Hypoleptinemia in women athletes: absence of a diurnal rhythm with amenorrhea. . Clin Endocrinol Metab 1997;82:318-321.
-
(1997)
J Clin Endocrinol Metab
, vol.82
, pp. 318-321
-
-
Laughlin, G.A.1
Yen, S.S.2
-
117
-
-
0033849777
-
Obesity and insulin resistance
-
Kahn BB, Flier JS. Obesity and insulin resistance. . Clin Invest 2000;106: 473-481.
-
(2000)
J Clin Invest
, vol.106
, pp. 473-481
-
-
Kahn, B.B.1
Flier, J.S.2
-
118
-
-
0032464788
-
Lipoprotein lipase and the disposition of dietary fatty acids
-
Fielding BA, Frayn KN. Lipoprotein lipase and the disposition of dietary fatty acids. Br J Nutr 1998;80:495-502.
-
(1998)
Br J Nutr
, vol.80
, pp. 495-502
-
-
Fielding, B.A.1
Frayn, K.N.2
-
119
-
-
0032529189
-
Caenorhabditis elegans Akt/PKB transduces insulin receptor-like signals from AGE-1 PI3 kinase to the DAF-16 transcription factor
-
Paradis S, Ruvkun G. Caenorhabditis elegans Akt/PKB transduces insulin receptor-like signals from AGE-1 PI3 kinase to the DAF-16 transcription factor. Genes Dev 1998;12:2488-2498.
-
(1998)
Genes Dev
, vol.12
, pp. 2488-2498
-
-
Paradis, S.1
Ruvkun, G.2
-
120
-
-
0031616132
-
The IRS-signaling system: a network of docking proteins that mediate insulin and cytokine action
-
White MF. The IRS-signaling system: a network of docking proteins that mediate insulin and cytokine action. Recent Prog Horm Res 1998;53:119-138.
-
(1998)
Recent Prog Horm Res
, vol.53
, pp. 119-138
-
-
White, M.F.1
-
121
-
-
0032566525
-
Platelet-derived growth factor inhibits insulin stimulation of insulin receptor substrate-1-associated phosphatidylinositol 3-kinase in 3T3-L1 adipocytes without affecting glucose transport
-
Staubs PA, Nelson JG, Reichart DR, et al. Platelet-derived growth factor inhibits insulin stimulation of insulin receptor substrate-1-associated phosphatidylinositol 3-kinase in 3T3-L1 adipocytes without affecting glucose transport. . Biol Chem 1998;273:25139-25147.
-
(1998)
J Biol Chem
, vol.273
, pp. 25139-25147
-
-
Staubs, P.A.1
Nelson, J.G.2
Reichart, D.R.3
-
122
-
-
0033593461
-
Signaling mechanisms that regulate glucose transport
-
Czech MP, Corvera S. Signaling mechanisms that regulate glucose transport. . Biol Chem 1999;274:1865-1868.
-
(1999)
J Biol Chem
, vol.274
, pp. 1865-1868
-
-
Czech, M.P.1
Corvera, S.2
-
123
-
-
0033049422
-
Protein kinase B/Akt participates in GLUT4 translocation by insulin in L6 myoblasts
-
Wang Q, Somwar R, Bilan PJ, et al. Protein kinase B/Akt participates in GLUT4 translocation by insulin in L6 myoblasts. Mol Cell Biol 1999;19:4008-4018.
-
(1999)
Mol Cell Biol
, vol.19
, pp. 4008-4018
-
-
Wang, Q.1
Somwar, R.2
Bilan, P.J.3
-
124
-
-
0031806103
-
Requirement for activation of the serine-threonine kinase Akt (protein kinase B) in insulin stimulation of protein synthesis but not of glucose transport
-
Kitamura T, Ogawa W, Sakaue H, et al. Requirement for activation of the serine-threonine kinase Akt (protein kinase B) in insulin stimulation of protein synthesis but not of glucose transport. Mol Cell Biol 1998;18:3708-3717.
-
(1998)
Mol Cell Biol
, vol.18
, pp. 3708-3717
-
-
Kitamura, T.1
Ogawa, W.2
Sakaue, H.3
-
125
-
-
0031724590
-
Requirement of atypical protein kinase C lambda for insulin stimulation of glucose uptake but not for Akt activation in 3T3-L1 adipocytes
-
Kotani K, Ogawa W, Matsumoto M, et al. Requirement of atypical protein kinase C lambda for insulin stimulation of glucose uptake but not for Akt activation in 3T3-L1 adipocytes. Mol Cell Biol 1998;18:6971-6982.
-
(1998)
Mol Cell Biol
, vol.18
, pp. 6971-6982
-
-
Kotani, K.1
Ogawa, W.2
Matsumoto, M.3
-
126
-
-
0032766006
-
Insulin-induced phosphorylation and activation of cyclic nucleotide phosphodiesterase 3B by the serine-threonine kinase Akt
-
Kitamura T, Kitamura Y, Kuroda S, et al. Insulin-induced phosphorylation and activation of cyclic nucleotide phosphodiesterase 3B by the serine-threonine kinase Akt. Mol Cell Biol 1999;19:6286-6296.
-
(1999)
Mol Cell Biol
, vol.19
, pp. 6286-6296
-
-
Kitamura, T.1
Kitamura, Y.2
Kuroda, S.3
-
127
-
-
0031963963
-
Nutritional and insulin regulation of fatty acid synthetase and leptin gene expression through ADD1/SREBP1
-
Kim J, Sarraf P, Wright M, et al. Nutritional and insulin regulation of fatty acid synthetase and leptin gene expression through ADD1/SREBP1. . Clin Invest 1998;101:1-9.
-
(1998)
J Clin Invest
, vol.101
, pp. 1-9
-
-
Kim, J.1
Sarraf, P.2
Wright, M.3
-
128
-
-
0033570119
-
Increased levels of nuclear SREBP-1c associated with fatty livers in two mouse models of diabetes mellitus
-
Shimomura I, Bashmakov Y, Horton JD. Increased levels of nuclear SREBP-1c associated with fatty livers in two mouse models of diabetes mellitus. . Biol Chem 1999;274:30028-30032.
-
(1999)
J Biol Chem
, vol.274
, pp. 30028-30032
-
-
Shimomura, I.1
Bashmakov, Y.2
Horton, J.D.3
-
129
-
-
0033607176
-
Sterol regulatory element binding protein-1c is a major mediator of insulin action on the hepatic expression of glucokinase and lipogenesis-related genes
-
Foretz M, Guichard C, Ferre P, et al. Sterol regulatory element binding protein-1c is a major mediator of insulin action on the hepatic expression of glucokinase and lipogenesis-related genes. Proc Natl Acad Sci U S A 1999;96: 12737-12742.
-
(1999)
Proc Natl Acad Sci U S A
, vol.96
, pp. 12737-12742
-
-
Foretz, M.1
Guichard, C.2
Ferre, P.3
-
130
-
-
0032759047
-
Forkhead transcription factors: new insights into protein kinase B (c-Akt) signaling
-
Kops GJ, Burgering BM. Forkhead transcription factors: new insights into protein kinase B (c-Akt) signaling. . Mol Med 1999;77:656-665.
-
(1999)
J Mol Med
, vol.77
, pp. 656-665
-
-
Kops, G.J.1
Burgering, B.M.2
-
131
-
-
0038187621
-
Insulin-regulated hepatic gluconeogenesis through FOXO1-PGC-1alpha interaction
-
Puigserver P, Rhee J, Donovan J, et al. Insulin-regulated hepatic gluconeogenesis through FOXO1-PGC-1alpha interaction. Nature 2003;423:550-555.
-
(2003)
Nature
, vol.423
, pp. 550-555
-
-
Puigserver, P.1
Rhee, J.2
Donovan, J.3
-
132
-
-
0029037649
-
Pathophysiology of insulin resistance in human disease
-
Reaven GM. Pathophysiology of insulin resistance in human disease. Physiol Rev 1995;75:473-486.
-
(1995)
Physiol Rev
, vol.75
, pp. 473-486
-
-
Reaven, G.M.1
-
134
-
-
84971016304
-
The C57BL/6J mouse as a model of insulin resistance and hypertension. In: Hansen BC, ed
-
Madras: Newgen Imaging Systems
-
Martin T, Collins S, Surwit RS. The C57BL/6J mouse as a model of insulin resistance and hypertension. In: Hansen BC, ed. Lessons from animal diabetes. Madras: Newgen Imaging Systems, 2002:73-86.
-
(2002)
Lessons from animal diabetes.
, pp. 73-86
-
-
Martin, T.1
Collins, S.2
Surwit, R.S.3
-
135
-
-
0030890580
-
Insulin receptor substrate (IRS) 1 is reduced and IRS-2 is the main docking protein for phosphatidylinositol 3-kinase in adipocytes from subjects with non-insulin-dependent diabetes mellitus
-
Rondinone CM, Wang LM, Lonnroth P, et al. Insulin receptor substrate (IRS) 1 is reduced and IRS-2 is the main docking protein for phosphatidylinositol 3-kinase in adipocytes from subjects with non-insulin-dependent diabetes mellitus. Proc Natl Acad Sci U S A 1997;94;4171-4175.
-
(1997)
Proc Natl Acad Sci U S A
, vol.94
, pp. 4171-4175
-
-
Rondinone, C.M.1
Wang, L.M.2
Lonnroth, P.3
-
136
-
-
0034635374
-
Tyrosine dephosphorylation and deactivation of insulin receptor substrate-1 by protein-tyrosine phosphatase 1B: possible facilitation by the formation of a ternary complex with the Grb2 adaptor protein
-
Goldstein B, Bittner-Kowalczyk J, White A, et al. Tyrosine dephosphorylation and deactivation of insulin receptor substrate-1 by protein-tyrosine phosphatase 1B: possible facilitation by the formation of a ternary complex with the Grb2 adaptor protein. . Biol Chem 2000;275:4283-4289.
-
(2000)
J Biol Chem
, vol.275
, pp. 4283-4289
-
-
Goldstein, B.1
Bittner-Kowalczyk, J.2
White, A.3
-
137
-
-
0035942161
-
Overexpression of the LAR (leukocyte antigen-related) protein-tyrosine phosphatase in muscle causes insulin resistance
-
Zabolotny JM, Kim YB, Peroni OD, et al. Overexpression of the LAR (leukocyte antigen-related) protein-tyrosine phosphatase in muscle causes insulin resistance. Proc Natl Acad Sci U S A 2001;98:5187-5192.
-
(2001)
Proc Natl Acad Sci U S A
, vol.98
, pp. 5187-5192
-
-
Zabolotny, J.M.1
Kim, Y.B.2
Peroni, O.D.3
-
138
-
-
2642541849
-
Transgenic overexpression of proteintyrosine phosphatase 1B in muscle causes insulin resistance, but overexpression with leukocyte antigen-related phosphatase does not additively impair insulin action
-
Zabolotny JM, Haj FG, Kim YB, et al. Transgenic overexpression of proteintyrosine phosphatase 1B in muscle causes insulin resistance, but overexpression with leukocyte antigen-related phosphatase does not additively impair insulin action. . Biol Chem 2004;279:24844-24851.
-
(2004)
J Biol Chem
, vol.279
, pp. 24844-24851
-
-
Zabolotny, J.M.1
Haj, F.G.2
Kim, Y.B.3
-
139
-
-
0033525870
-
Increased insulin sensitivity and obesity resistance in mice lacking the protein tyrosine phosphatase-1B gene
-
Elchebly M, Payette P, Michaliszyn E, et al. Increased insulin sensitivity and obesity resistance in mice lacking the protein tyrosine phosphatase-1B gene. Science 1999;283:1544-1548.
-
(1999)
Science
, vol.283
, pp. 1544-1548
-
-
Elchebly, M.1
Payette, P.2
Michaliszyn, E.3
-
140
-
-
0031594367
-
Transgenic mice deficient in the LAR protein-tyrosine phosphatase exhibit profound defects in glucose homeostasis
-
Ren JM, Li PM, Zhang WR, et al. Transgenic mice deficient in the LAR protein-tyrosine phosphatase exhibit profound defects in glucose homeostasis. Diabetes 1998;47:493-497.
-
(1998)
Diabetes
, vol.47
, pp. 493-497
-
-
Ren, J.M.1
Li, P.M.2
Zhang, W.R.3
-
141
-
-
0036228770
-
Attenuation of leptin action and regulation of obesity by protein tyrosine phosphatase 1B
-
Cheng A, Uetani N, Simoncic PD, et al. Attenuation of leptin action and regulation of obesity by protein tyrosine phosphatase 1B. Dev Cell 2002;2:497-503.
-
(2002)
Dev Cell
, vol.2
, pp. 497-503
-
-
Cheng, A.1
Uetani, N.2
Simoncic, P.D.3
-
143
-
-
0022036226
-
Dose-response curves for in vivo insulin sensitivity in individual tissues in rats
-
Kraegen EW, James DE, Jenkins AB, et al. Dose-response curves for in vivo insulin sensitivity in individual tissues in rats. Am J Physiol 1985;248:E353-362.
-
(1985)
Am J Physiol
, vol.248
, pp. E353-E362
-
-
Kraegen, E.W.1
James, D.E.2
Jenkins, A.B.3
-
144
-
-
0027453501
-
Adipose tissue hyperplasia and enhanced glucose disposal in transgenic mice overexpressing GLUT4 selectively in adipose tissue
-
Shepherd PR, Gnudi L, Tozzi E, et al. Adipose tissue hyperplasia and enhanced glucose disposal in transgenic mice overexpressing GLUT4 selectively in adipose tissue. . Biol Chem 1993;268:22243-22246.
-
(1993)
J Biol Chem
, vol.268
, pp. 22243-22246
-
-
Shepherd, P.R.1
Gnudi, L.2
Tozzi, E.3
-
145
-
-
0030988551
-
Amelioration of insulin resistance in streptozocin diabetic mice by transgenic overexpression of GLUT4 driven by an adipose-specific promoter
-
Tozzo E, Gnudi L, Kahn BB. Amelioration of insulin resistance in streptozocin diabetic mice by transgenic overexpression of GLUT4 driven by an adipose-specific promoter. Endocrinology 1997;138:1604-1611.
-
(1997)
Endocrinology
, vol.138
, pp. 1604-1611
-
-
Tozzo, E.1
Gnudi, L.2
Kahn, B.B.3
-
146
-
-
0035825643
-
Adipose-selective targeting of the GLUT4 gene impairs insulin action in muscle and liver
-
Abel ED, Peroni O, Kim JK, et al. Adipose-selective targeting of the GLUT4 gene impairs insulin action in muscle and liver. Nature 2001;409:729-733.
-
(2001)
Nature
, vol.409
, pp. 729-733
-
-
Abel, E.D.1
Peroni, O.2
Kim, J.K.3
-
147
-
-
0025148179
-
Weight as a risk factor for clinical diabetes in women
-
Colditz GA, Willett WC, Stampfer MJ, et al. Weight as a risk factor for clinical diabetes in women. Am J Epidemiol 1990;132:501-513.
-
(1990)
Am J Epidemiol
, vol.132
, pp. 501-513
-
-
Colditz, G.A.1
Willett, W.C.2
Stampfer, M.J.3
-
148
-
-
0343683306
-
Body fat distribution, insulin resistance, and metabolic diseases
-
Bjorntorp P. Body fat distribution, insulin resistance, and metabolic diseases. Nutrition 1997;13:795-803.
-
(1997)
Nutrition
, vol.13
, pp. 795-803
-
-
Bjorntorp, P.1
-
149
-
-
0035034068
-
Racial differences in rates of type 2 diabetes in American women: how much is due to differences in overall adiposity
-
Okosun IS. Racial differences in rates of type 2 diabetes in American women: how much is due to differences in overall adiposity? Ethn Health 2001;6: 27-34.
-
(2001)
Ethn Health
, vol.6
, pp. 27-34
-
-
Okosun, I.S.1
-
150
-
-
0028091785
-
Regional adiposity and morbidity
-
Kissebah AH, Krakower GR. Regional adiposity and morbidity. Physiol Rev 1994;74:761-811.
-
(1994)
Physiol Rev
, vol.74
, pp. 761-811
-
-
Kissebah, A.H.1
Krakower, G.R.2
-
151
-
-
0033779714
-
Free fatty acids and pathogenesis of type 2 diabetes mellitus
-
Bergman RN, Ader M. Free fatty acids and pathogenesis of type 2 diabetes mellitus. Trends Endocrinol Metab 2000;11:351-356.
-
(2000)
Trends Endocrinol Metab
, vol.11
, pp. 351-356
-
-
Bergman, R.N.1
Ader, M.2
-
152
-
-
0030296425
-
Lessons from transgenic and knockout animals about noninsulin-dependent diabetes mellitus
-
Patti M-E, Kahn CR. Lessons from transgenic and knockout animals about noninsulin-dependent diabetes mellitus. Trends Endocrinol Metab 1996;7: 311-319.
-
(1996)
Trends Endocrinol Metab
, vol.7
, pp. 311-319
-
-
Patti, M.-E.1
Kahn, C.R.2
-
153
-
-
0029151863
-
Lipotoxicity in the pathogenesis of obesity-dependent NIDDM
-
Unger RH. Lipotoxicity in the pathogenesis of obesity-dependent NIDDM. Diabetes 1995;44:863-870.
-
(1995)
Diabetes
, vol.44
, pp. 863-870
-
-
Unger, R.H.1
-
154
-
-
0345086474
-
Free fatty acid-induced insulin resistance is associated with activation of protein kinase C theta and alterations in the insulin signaling cascade
-
Griffin ME, Marcucci MJ, Cline GW, et al. Free fatty acid-induced insulin resistance is associated with activation of protein kinase C theta and alterations in the insulin signaling cascade. Diabetes 1999;48:1270-1274.
-
(1999)
Diabetes
, vol.48
, pp. 1270-1274
-
-
Griffin, M.E.1
Marcucci, M.J.2
Cline, G.W.3
-
155
-
-
0030987889
-
High-fat feeding impairs insulinstimulated GLUT4 recruitment via an early insulin-signaling defect
-
Zierath JR, Houseknecht KL, Gnudi L, et al. High-fat feeding impairs insulinstimulated GLUT4 recruitment via an early insulin-signaling defect. Diabetes 1997;46:215-223.
-
(1997)
Diabetes
, vol.46
, pp. 215-223
-
-
Zierath, J.R.1
Houseknecht, K.L.2
Gnudi, L.3
-
156
-
-
0027395358
-
The relation between insulin sensitivity and the fatty-acid composition of skeletal-muscle phospholipids
-
Borkman M, Storlien LH, Pan DA, et al. The relation between insulin sensitivity and the fatty-acid composition of skeletal-muscle phospholipids. . Engl J Med 1993;328:238-244.
-
(1993)
N Engl J Med
, vol.328
, pp. 238-244
-
-
Borkman, M.1
Storlien, L.H.2
Pan, D.A.3
-
157
-
-
0032484132
-
Lipoapoptosis in beta-cells of obese prediabetic fa/fa rats. Role of serine palmitoyltransferase overexpression
-
Shimabukuro M, Higa M, Zhou YT, et al. Lipoapoptosis in beta-cells of obese prediabetic fa/fa rats. Role of serine palmitoyltransferase overexpression. . Biol Chem 1998;273:32487-32490.
-
(1998)
J Biol Chem
, vol.273
, pp. 32487-32490
-
-
Shimabukuro, M.1
Higa, M.2
Zhou, Y.T.3
-
158
-
-
0033517284
-
Leptin reverses insulin resistance and diabetes mellitus in mice with congenital lipodystrophy
-
Shimomura I, Hammer RE, Ikemoto S, et al. Leptin reverses insulin resistance and diabetes mellitus in mice with congenital lipodystrophy. Nature 1999;401:73-76.
-
(1999)
Nature
, vol.401
, pp. 73-76
-
-
Shimomura, I.1
Hammer, R.E.2
Ikemoto, S.3
-
159
-
-
0033965557
-
Surgical implantation of adipose tissue reverses diabetes in lipoatrophic mice
-
Gavrilova O, Marcus-Samuels B, Graham D, et al. Surgical implantation of adipose tissue reverses diabetes in lipoatrophic mice. . Clin Invest 2000;105:271-278.
-
(2000)
J Clin Invest
, vol.105
, pp. 271-278
-
-
Gavrilova, O.1
Marcus-Samuels, B.2
Graham, D.3
-
160
-
-
0032848779
-
Increased glucose metabolism and insulin sensitivity in transgenic skinny mice overexpressing leptin
-
Ogawa Y, Masuzaki H, Hosoda K, et al. Increased glucose metabolism and insulin sensitivity in transgenic skinny mice overexpressing leptin. Diabetes 1999;48:1822-1829.
-
(1999)
Diabetes
, vol.48
, pp. 1822-1829
-
-
Ogawa, Y.1
Masuzaki, H.2
Hosoda, K.3
-
161
-
-
0036100839
-
Leptin: a novel therapeutic role in lipodystrophy
-
Savage DB, O'Reilly S. Leptin: a novel therapeutic role in lipodystrophy. . Clin Invest 2002;109:1285-1286.
-
(2002)
J Clin Invest
, vol.109
, pp. 1285-1286
-
-
Savage, D.B.1
O'Reilly, S.2
-
162
-
-
0036114844
-
Leptin reverses insulin resistance and hepatic steatosis in patients with severe lipodystrophy
-
Petersen KF, Oral EA, Dufour S, et al. Leptin reverses insulin resistance and hepatic steatosis in patients with severe lipodystrophy. . Clin Invest 2002;109: 1345-1350.
-
(2002)
J Clin Invest
, vol.109
, pp. 1345-1350
-
-
Petersen, K.F.1
Oral, E.A.2
Dufour, S.3
-
163
-
-
0037148928
-
Leptin-replacement therapy for lipodystrophy
-
Oral EA, Simha V, Ruiz E, et al. Leptin-replacement therapy for lipodystrophy. . Engl J Med 2002;346:570-578.
-
(2002)
N Engl J Med
, vol.346
, pp. 570-578
-
-
Oral, E.A.1
Simha, V.2
Ruiz, E.3
-
164
-
-
0037122766
-
Leptin stimulates fatty-acid oxidation by activating AMP-activated protein kinase
-
Minokoshi Y, Kim YB, Peroni OD, et al. Leptin stimulates fatty-acid oxidation by activating AMP-activated protein kinase. Nature 2002;415:339-343.
-
(2002)
Nature
, vol.415
, pp. 339-343
-
-
Minokoshi, Y.1
Kim, Y.B.2
Peroni, O.D.3
-
166
-
-
0027536169
-
Coexistence of beta 1-, beta 2-, and beta 3-adrenoceptors in dog fat cells and their differential activation by catecholamines
-
Galitzky J, Reverte M, Portill M, et al. Coexistence of beta 1-, beta 2-, and beta 3-adrenoceptors in dog fat cells and their differential activation by catecholamines. Am J Physiol 1993;264:E403-E412.
-
(1993)
Am J Physiol
, vol.264
, pp. E403-E412
-
-
Galitzky, J.1
Reverte, M.2
Portill, M.3
-
167
-
-
0028281432
-
Impaired expression and functional activity of the beta 3-and beta 1-adrenergic receptors in adipose tissue of congenitally obese (C57BL/6J ob/ob) mice
-
Collins S, Daniel KW, Rohlfs EM, et al. Impaired expression and functional activity of the beta 3-and beta 1-adrenergic receptors in adipose tissue of congenitally obese (C57BL/6J ob/ob) mice. Mol Endocrinol 1994;8:516-527.
-
(1994)
Mol Endocrinol
, vol.8
, pp. 516-527
-
-
Collins, S.1
Daniel, K.W.2
Rohlfs, E.M.3
-
168
-
-
0031252806
-
Role of beta1-and beta3-adrenoceptors in the regulation of lipolysis and thermogenesis in rat brown adipocytes
-
Atgie C, D'Allaire F, Bukowiecki LJ. Role of beta1-and beta3-adrenoceptors in the regulation of lipolysis and thermogenesis in rat brown adipocytes. Am J Physiol 1997;273:C1136-C1142.
-
(1997)
Am J Physiol
, vol.273
, pp. C1136-C1142
-
-
Atgie, C.1
D'Allaire, F.2
Bukowiecki, L.J.3
-
169
-
-
0031686860
-
Physiological consequences of D-adrenergic receptor disruption
-
Rohrer DK. Physiological consequences of D-adrenergic receptor disruption. . Mol Med 1999;76:764-772.
-
(1999)
J Mol Med
, vol.76
, pp. 764-772
-
-
Rohrer, D.K.1
-
170
-
-
0037008157
-
BetaAR signaling is required for diet-induced thermogenesis and obesity resistance
-
Bachman ES, Dhillon H, Zhang CY, et al. BetaAR signaling is required for diet-induced thermogenesis and obesity resistance. Science 2002;297:843-845.
-
(2002)
Science
, vol.297
, pp. 843-845
-
-
Bachman, E.S.1
Dhillon, H.2
Zhang, C.Y.3
-
171
-
-
18644381610
-
et al. Beta(1)/beta(2)/beta(3)-adrenoceptor knockout mice are obese and cold-sensitive but have normal lipolytic responses to fasting
-
Jimenez M, Leger B, Canola K. et al. Beta(1)/beta(2)/beta(3)-adrenoceptor knockout mice are obese and cold-sensitive but have normal lipolytic responses to fasting. FEBS Lett 2002;530:37-40.
-
(2002)
FEBS Lett
, vol.530
, pp. 37-40
-
-
Jimenez, M.1
Leger, B.2
Canola, K.3
-
172
-
-
0033596981
-
The D3-adrenergic receptor activates mitogen-activated protein kinase in adipocytes through a Gi-dependent mechanism
-
Soeder KS, Snedden SK, Cao W, et al. The D3-adrenergic receptor activates mitogen-activated protein kinase in adipocytes through a Gi-dependent mechanism. . Biol Chem 1999;274:12017-12022.
-
(1999)
J Biol Chem
, vol.274
, pp. 12017-12022
-
-
Soeder, K.S.1
Snedden, S.K.2
Cao, W.3
-
173
-
-
0035920122
-
D-Adrenergic activation of p38 MAP kinase in adipocytes: cAMP induction of the uncoupling protein-1 (UCP1) gene requires p38 MAP kinase
-
Cao W, Medvedev AV, Daniel KW, et al. D-Adrenergic activation of p38 MAP kinase in adipocytes: cAMP induction of the uncoupling protein-1 (UCP1) gene requires p38 MAP kinase. . Biol Chem 2001;276:27077-27082.
-
(2001)
J Biol Chem
, vol.276
, pp. 27077-27082
-
-
Cao, W.1
Medvedev, A.V.2
Daniel, K.W.3
-
174
-
-
0031731021
-
The activation of p38 MAPK by the beta-adrenergic agonist isoproterenol in rat epididymal fat cells
-
Moule SK, Denton RM. The activation of p38 MAPK by the beta-adrenergic agonist isoproterenol in rat epididymal fat cells. FEBS Lett 1998;439:287-290.
-
(1998)
FEBS Lett
, vol.439
, pp. 287-290
-
-
Moule, S.K.1
Denton, R.M.2
-
175
-
-
0035976955
-
Stimulation of lipolysis and hormone-sensitive lipase via the extracellular signal-regulated kinase pathway
-
Greenberg AS, Shen WJ, Muliro K, et al. Stimulation of lipolysis and hormone-sensitive lipase via the extracellular signal-regulated kinase pathway. . Biol Chem 2001;276:45456-45461.
-
(2001)
J Biol Chem
, vol.276
, pp. 45456-45461
-
-
Greenberg, A.S.1
Shen, W.J.2
Muliro, K.3
-
177
-
-
0028972839
-
Fat cell 2-adrenoceptors: the regulation of fat cell function and lipolysis
-
Lafontan M, Berlan M. Fat cell 2-adrenoceptors: the regulation of fat cell function and lipolysis. Endocr Rev 1995;16:716-738.
-
(1995)
Endocr Rev
, vol.16
, pp. 716-738
-
-
Lafontan, M.1
Berlan, M.2
-
178
-
-
0029813768
-
The D3-adrenergic receptor inhibits insulin-stimulated leptin secretion from isolated rat adipocytes
-
Gettys TW, Harkness PJ, Watson PM. The D3-adrenergic receptor inhibits insulin-stimulated leptin secretion from isolated rat adipocytes. Endocrinology 1996;137:4054-4057.
-
(1996)
Endocrinology
, vol.137
, pp. 4054-4057
-
-
Gettys, T.W.1
Harkness, P.J.2
Watson, P.M.3
-
179
-
-
0030735541
-
Isoproterenol and somatostatin decrease plasma leptin in humans: a novel mechanism regulating leptin secretion
-
Donahoo WT, Jensen DR, Yost TJ, et al. Isoproterenol and somatostatin decrease plasma leptin in humans: a novel mechanism regulating leptin secretion. . Clin Endocrinol Metab 1997;82:4139-4143.
-
(1997)
J Clin Endocrinol Metab
, vol.82
, pp. 4139-4143
-
-
Donahoo, W.T.1
Jensen, D.R.2
Yost, T.J.3
-
180
-
-
0033794784
-
Catecholamines suppress leptin release from in vitro differentiated subcutaneous human adipocytes in primary culture via beta1-and beta2-adrenergic receptors
-
Scriba D, Aprath-Husmann I, Blum WF, et al. Catecholamines suppress leptin release from in vitro differentiated subcutaneous human adipocytes in primary culture via beta1-and beta2-adrenergic receptors. Eur J Endocrinol 2000;143:439-445.
-
(2000)
Eur J Endocrinol
, vol.143
, pp. 439-445
-
-
Scriba, D.1
Aprath-Husmann, I.2
Blum, W.F.3
-
181
-
-
18644381610
-
beta(1)/beta(2)/beta(3)-adrenergic receptor knockout mice are obese and cold-sensitive but have normal lipolytic responses to fasting
-
Jimenez M, Leger B, Canola K, et al. beta(1)/beta(2)/beta(3)-adrenergic receptor knockout mice are obese and cold-sensitive but have normal lipolytic responses to fasting. FEBS Lett 2002;530:37.
-
(2002)
FEBS Lett
, vol.530
, pp. 37
-
-
Jimenez, M.1
Leger, B.2
Canola, K.3
-
182
-
-
0025836657
-
D3-Adrenergic receptor stimulation restores message and expression of brown-fat mitochondrial uncoupling protein in adult dogs
-
Champigny O, Ricquier D, Blondel O, et al. D3-Adrenergic receptor stimulation restores message and expression of brown-fat mitochondrial uncoupling protein in adult dogs. Proc Natl Acad Sci U S A 1991;88:10774-10777.
-
(1991)
Proc Natl Acad Sci U S A
, vol.88
, pp. 10774-10777
-
-
Champigny, O.1
Ricquier, D.2
Blondel, O.3
-
183
-
-
0028224485
-
Effect of CL-316,243, a thermogenic D3-agonist, on energy balance and brown and white adipose tissues in rats
-
Himms-Hagen J, Cui J, Danforth E Jr, et al. Effect of CL-316,243, a thermogenic D3-agonist, on energy balance and brown and white adipose tissues in rats. Am J Physiol 1994;266:R1371-R1382.
-
(1994)
Am J Physiol
, vol.266
, pp. R1371-R1382
-
-
Himms-Hagen, J.1
Cui, J.2
Danforth, E.3
-
184
-
-
0031025546
-
Strain-specific response to D3-adrenergic receptor agonist treatment of diet-induced obesity in mice
-
Collins S, Daniel KW, Petro AE, et al. Strain-specific response to D3-adrenergic receptor agonist treatment of diet-induced obesity in mice. Endocrinology 1997;138:405-413.
-
(1997)
Endocrinology
, vol.138
, pp. 405-413
-
-
Collins, S.1
Daniel, K.W.2
Petro, A.E.3
-
185
-
-
0031011161
-
Appearance of brown adipocytes in white adipose tissue during CL 316,243-induced reversal of obesity and diabetes in Zucker fa/fa rats
-
Ghorbani M, Himms-Hagen J. Appearance of brown adipocytes in white adipose tissue during CL 316,243-induced reversal of obesity and diabetes in Zucker fa/fa rats. Int J Obes Relat Metab Disord 1997;21:465-475.
-
(1997)
Int J Obes Relat Metab Disord
, vol.21
, pp. 465-475
-
-
Ghorbani, M.1
Himms-Hagen, J.2
-
186
-
-
0032081279
-
A selective human beta3 adrenergic receptor agonist increases metabolic rate in rhesus monkeys
-
Fisher MH, Amend AM, Bach TJ, et al. A selective human beta3 adrenergic receptor agonist increases metabolic rate in rhesus monkeys. . Clin Invest 1998;101:2387-2393.
-
(1998)
J Clin Invest
, vol.101
, pp. 2387-2393
-
-
Fisher, M.H.1
Amend, A.M.2
Bach, T.J.3
-
187
-
-
0032043141
-
Anti-obesity effects of selective agonists to the D3-adrenergic receptor in dogs. II. Recruitment of thermogenic brown adipocytes and reduction of adiposity after chronic treatment with a D3-adrenergic agonist
-
Sasaki N, Uchida E, Niiyama M, et al. Anti-obesity effects of selective agonists to the D3-adrenergic receptor in dogs. II. Recruitment of thermogenic brown adipocytes and reduction of adiposity after chronic treatment with a D3-adrenergic agonist. . Vet Med Sci 1998;60:465-469.
-
(1998)
J Vet Med Sci
, vol.60
, pp. 465-469
-
-
Sasaki, N.1
Uchida, E.2
Niiyama, M.3
-
188
-
-
0030745159
-
Hypertrophy of brown adipocytes in brown and white adipose tissues and reversal of diet-induced obesity in rats treated with a beta3-adrenoceptor agonist
-
Ghorbani M, Claus TH, Himms-Hagen J. Hypertrophy of brown adipocytes in brown and white adipose tissues and reversal of diet-induced obesity in rats treated with a beta3-adrenoceptor agonist. Biochem Pharmacol 1997;54: 121-131.
-
(1997)
Biochem Pharmacol
, vol.54
, pp. 121-131
-
-
Ghorbani, M.1
Claus, T.H.2
Himms-Hagen, J.3
-
189
-
-
0030803534
-
CL-316,243, a beta3-specific adrenoceptor agonist, enhances insulin-stimulated glucose disposal in nonobese rats
-
de Souza CJ, Hirshman MF, Horton ES. CL-316,243, a beta3-specific adrenoceptor agonist, enhances insulin-stimulated glucose disposal in nonobese rats. Diabetes 1997;46:1257-1263.
-
(1997)
Diabetes
, vol.46
, pp. 1257-1263
-
-
de Souza, C.J.1
Hirshman, M.F.2
Horton, E.S.3
-
190
-
-
0031661901
-
Increase in insulin action and fat oxidation after treatment with CL 316,243, a highly selective beta3-adrenoceptor agonist in humans
-
Weyer C, Tataranni PA, Snitker S, et al. Increase in insulin action and fat oxidation after treatment with CL 316,243, a highly selective beta3-adrenoceptor agonist in humans. Diabetes 1998;47:1555-1561.
-
(1998)
Diabetes
, vol.47
, pp. 1555-1561
-
-
Weyer, C.1
Tataranni, P.A.2
Snitker, S.3
-
191
-
-
0345327617
-
White adipose tissue contributes to UCP1-independent thermogenesis
-
Granneman JG, Burnazi M, Zhu Z, et al. White adipose tissue contributes to UCP1-independent thermogenesis. Am J Physiol Endocrinol Metab 2003;285: E1230-1236.
-
(2003)
Am J Physiol Endocrinol Metab
, vol.285
, pp. E1230-E1236
-
-
Granneman, J.G.1
Burnazi, M.2
Zhu, Z.3
-
192
-
-
0037304599
-
Mitochondrial biogenesis and remodeling during adipogenesis and in response to the insulin sensitizer rosiglitazone
-
Wilson-Fritch L, Burkart A, Bell G, et al. Mitochondrial biogenesis and remodeling during adipogenesis and in response to the insulin sensitizer rosiglitazone. Mol Cell Biol 2003;23:1085-1094.
-
(2003)
Mol Cell Biol
, vol.23
, pp. 1085-1094
-
-
Wilson-Fritch, L.1
Burkart, A.2
Bell, G.3
-
195
-
-
0033655538
-
Androgen effect on body composition and fat metabolism
-
Jensen MD. Androgen effect on body composition and fat metabolism. Mayo Clin Proc 2000;75[Suppl]:S65-68.
-
(2000)
Mayo Clin Proc
, vol.75
, pp. S65-S68
-
-
Jensen, M.D.1
-
196
-
-
0034474076
-
Sex steroid hormones, sex hormone-binding globulin, and obesity in men and women
-
Tchernof A, Despres JP. Sex steroid hormones, sex hormone-binding globulin, and obesity in men and women. Horm Metab Res 2000;32:526-536.
-
(2000)
Horm Metab Res
, vol.32
, pp. 526-536
-
-
Tchernof, A.1
Despres, J.P.2
-
197
-
-
85047683614
-
Minireview: 11beta-hydroxysteroid dehydrogenase type 1-a tissue-specific amplifier of glucocorticoid action
-
Seckl JR, Walker BR. Minireview: 11beta-hydroxysteroid dehydrogenase type 1-a tissue-specific amplifier of glucocorticoid action. Endocrinology 2001; 142:1371-1376.
-
(2001)
Endocrinology
, vol.142
, pp. 1371-1376
-
-
Seckl, J.R.1
Walker, B.R.2
-
198
-
-
0031948398
-
Cortisol, hypertension and obesity: the role of 11 beta-hydroxysteroid dehydrogenase
-
Stewart PM. Cortisol, hypertension and obesity: the role of 11 beta-hydroxysteroid dehydrogenase. . R Coll Physicians Lond 1998;32:154-159.
-
(1998)
J R Coll Physicians Lond
, vol.32
, pp. 154-159
-
-
Stewart, P.M.1
-
199
-
-
0035824440
-
A transgenic model of visceral obesity and the metabolic syndrome
-
Masuzaki H, Paterson J, Shinyama H, et al. A transgenic model of visceral obesity and the metabolic syndrome. Science 2001;294:2166-2170.
-
(2001)
Science
, vol.294
, pp. 2166-2170
-
-
Masuzaki, H.1
Paterson, J.2
Shinyama, H.3
-
200
-
-
0030936556
-
Does central obesity reflect "Cushing's disease of the omentum"
-
Bujalska IJ, Kumar S, Stewart PM. Does central obesity reflect "Cushing's disease of the omentum"? Lancet 1997;349:1210-1213.
-
(1997)
Lancet
, vol.349
, pp. 1210-1213
-
-
Bujalska, I.J.1
Kumar, S.2
Stewart, P.M.3
-
201
-
-
0035824440
-
A transgenic model of visceral obesity and the metabolic syndrome
-
Masuzaki H, Paterson J, Shinyama H, et al. A transgenic model of visceral obesity and the metabolic syndrome. Science 2001;294:2166-2170.
-
(2001)
Science
, vol.294
, pp. 2166-2170
-
-
Masuzaki, H.1
Paterson, J.2
Shinyama, H.3
-
202
-
-
12144291638
-
Novel adipose tissue-mediated resistance to diet-induced visceral obesity in 11D-hydroxysteroid dehydrogenase type 1-deficient mice
-
Morton NM, Paterson JM, Masuzaki H, et al. Novel adipose tissue-mediated resistance to diet-induced visceral obesity in 11D-hydroxysteroid dehydrogenase type 1-deficient mice. Diabetes 2004;53:931-938.
-
(2004)
Diabetes
, vol.53
, pp. 931-938
-
-
Morton, N.M.1
Paterson, J.M.2
Masuzaki, H.3
-
203
-
-
0035798621
-
Improved lipid and lipoprotein profile, hepatic insulin sensitivity, and glucose tolerance in 11D-hydroxysteroid dehydrogenase type 1 null mice
-
Morton NM, Holmes MC, Fievet C, et al. Improved lipid and lipoprotein profile, hepatic insulin sensitivity, and glucose tolerance in 11D-hydroxysteroid dehydrogenase type 1 null mice. . Biol Chem 2004;276:41293-41300.
-
(2004)
J Biol Chem
, vol.276
, pp. 41293-41300
-
-
Morton, N.M.1
Holmes, M.C.2
Fievet, C.3
-
204
-
-
0024405827
-
The biology of cachectin/TNF-a primary mediator of the host response
-
Beutler B, Cerami A. The biology of cachectin/TNF-a primary mediator of the host response. Annu Rev Immunol 1989;7:625-655.
-
(1989)
Annu Rev Immunol
, vol.7
, pp. 625-655
-
-
Beutler, B.1
Cerami, A.2
-
205
-
-
0026549669
-
Tumor necrosis factor impairs insulin action on peripheral glucose disposal and hepatic glucose output
-
Lang CH, Dobrescu C, Bagby GJ. Tumor necrosis factor impairs insulin action on peripheral glucose disposal and hepatic glucose output. Endocrinology 1992;130:43-52.
-
(1992)
Endocrinology
, vol.130
, pp. 43-52
-
-
Lang, C.H.1
Dobrescu, C.2
Bagby, G.J.3
-
206
-
-
0027459878
-
Adipose expression of tumor necrosis factor-alpha: direct role in obesity-linked insulin resistance
-
Hotamisligil G, Shargill N, Spiegelman B. Adipose expression of tumor necrosis factor-alpha: direct role in obesity-linked insulin resistance. Science 1993;259:87-91.
-
(1993)
Science
, vol.259
, pp. 87-91
-
-
Hotamisligil, G.1
Shargill, N.2
Spiegelman, B.3
-
207
-
-
0028931724
-
Increased adipose tissue expression of tumor necrosis factor-α in human obesity and insulin resistance
-
Hotamisligil GS, Arner P, Caro JF, et al. Increased adipose tissue expression of tumor necrosis factor-α in human obesity and insulin resistance. Clin Invest 1995;95:2409-2415.
-
(1995)
J Clin Invest
, vol.95
, pp. 2409-2415
-
-
Hotamisligil, G.S.1
Arner, P.2
Caro, J.F.3
-
208
-
-
0032587240
-
The role of TNFalpha and TNF receptors in obesity and insulin resistance
-
Hotamisligil GS. The role of TNFalpha and TNF receptors in obesity and insulin resistance. . Intern Med 1999;245:621-625.
-
(1999)
J Intern Med
, vol.245
, pp. 621-625
-
-
Hotamisligil, G.S.1
-
209
-
-
0031762908
-
Omental and subcutaneous adipose tissues of obese subjects release interleukin-6: depot difference and regulation by glucocorticoid
-
Fried SK, Bunkin DA, Greenberg AS. Omental and subcutaneous adipose tissues of obese subjects release interleukin-6: depot difference and regulation by glucocorticoid. . Clin Endocrinol Metab 1998;83:847-850.
-
(1998)
J Clin Endocrinol Metab
, vol.83
, pp. 847-850
-
-
Fried, S.K.1
Bunkin, D.A.2
Greenberg, A.S.3
-
210
-
-
0032943709
-
C-reactive protein in healthy subjects: associations with obesity, insulin resistance, and endothelial dysfunction: a potential role for cytokines originating from adipose tissue
-
Yudkin JS, Stehouwer CD, Emeis JJ, et al. C-reactive protein in healthy subjects: associations with obesity, insulin resistance, and endothelial dysfunction: a potential role for cytokines originating from adipose tissue? Arterioscler Thromb Vasc Biol 1999;19:972-978.
-
(1999)
Arterioscler Thromb Vasc Biol
, vol.19
, pp. 972-978
-
-
Yudkin, J.S.1
Stehouwer, C.D.2
Emeis, J.J.3
-
211
-
-
15844381594
-
Enhanced expression of PAI-1 in visceral fat: possible contributor to vascular disease in obesity
-
Shimomura I, Funahashi T, Takahashi M, et al. Enhanced expression of PAI-1 in visceral fat: possible contributor to vascular disease in obesity. Nat Med 1996;2:800-803.
-
(1996)
Nat Med
, vol.2
, pp. 800-803
-
-
Shimomura, I.1
Funahashi, T.2
Takahashi, M.3
-
212
-
-
0032742971
-
Hemostatic gene expression and vascular disease in obesity: insights from studies of genetically obese mice
-
Samad F, Loskutoff DJ. Hemostatic gene expression and vascular disease in obesity: insights from studies of genetically obese mice. Thromb Haemost 1999;82:742-747.
-
(1999)
Thromb Haemost
, vol.82
, pp. 742-747
-
-
Samad, F.1
Loskutoff, D.J.2
-
213
-
-
0033071540
-
Role of adipocytokines on the pathogenesis of atherosclerosis in visceral obesity
-
Funahashi T, Nakamura T, Shimomura I, et al. Role of adipocytokines on the pathogenesis of atherosclerosis in visceral obesity. Intern Med 1999;38: 202-206.
-
(1999)
Intern Med
, vol.38
, pp. 202-206
-
-
Funahashi, T.1
Nakamura, T.2
Shimomura, I.3
-
214
-
-
0034043503
-
The fat mouse. Apowerful genetic model to study hemostatic gene expression in obesity/NIDDM
-
Loskutoff DJ, Fujisawa K, Samad F. The fat mouse. Apowerful genetic model to study hemostatic gene expression in obesity/NIDDM. Ann N Y Acad Sci 2000;902:272-281.
-
(2000)
Ann N Y Acad Sci
, vol.902
, pp. 272-281
-
-
Loskutoff, D.J.1
Fujisawa, K.2
Samad, F.3
-
215
-
-
0030803977
-
Nutrition and the immune system: an introduction
-
Chandra RK. Nutrition and the immune system: an introduction. Am J Clin Nutr 1997;66:460S-463S.
-
(1997)
Am J Clin Nutr
, vol.66
, pp. 460S-463S
-
-
Chandra, R.K.1
-
216
-
-
0035195887
-
Leptin regulation of the immune response and the immunodeficiency of malnutrition
-
Faggioni R, Feingold KR, Grunfeld C. Leptin regulation of the immune response and the immunodeficiency of malnutrition. FASEB J 2001;15: 2565-2571.
-
(2001)
FASEB J
, vol.15
, pp. 2565-2571
-
-
Faggioni, R.1
Feingold, K.R.2
Grunfeld, C.3
-
217
-
-
0017234902
-
The complement abnormalities of lipodystrophy
-
Sisson JG, West RJ, Fallow J, et al. The complement abnormalities of lipodystrophy. . Engl J Med 1976;294:461-465.
-
(1976)
N Engl J Med
, vol.294
, pp. 461-465
-
-
Sisson, J.G.1
West, R.J.2
Fallow, J.3
-
218
-
-
0023663615
-
Adipsin: a circulating serine protease homolog secreted by adipose tissue and sciatic nerve
-
Cook KS, Min HY, Johnson D, et al. Adipsin: a circulating serine protease homolog secreted by adipose tissue and sciatic nerve. Science 1987;237: 402-405.
-
(1987)
Science
, vol.237
, pp. 402-405
-
-
Cook, K.S.1
Min, H.Y.2
Johnson, D.3
-
219
-
-
0026638667
-
Adipsin and an endogenous pathway of complement from adipose cells
-
Choy LN, Rosen BS, Spiegelman BM. Adipsin and an endogenous pathway of complement from adipose cells. . Biol Chem 1992;267:12736-12741.
-
(1992)
J Biol Chem
, vol.267
, pp. 12736-12741
-
-
Choy, L.N.1
Rosen, B.S.2
Spiegelman, B.M.3
-
220
-
-
0023663610
-
Severely impaired adipsin expression in genetic and acquired obesity
-
Flier JS, Cook KS, Usher P, et al. Severely impaired adipsin expression in genetic and acquired obesity. Science 1987;237:405-408.
-
(1987)
Science
, vol.237
, pp. 405-408
-
-
Flier, J.S.1
Cook, K.S.2
Usher, P.3
-
221
-
-
0026794743
-
Human adipsin is identical to complement factor D and is expressed at high levels in adipose tissue
-
White RT, Damm D, Hancock N, et al. Human adipsin is identical to complement factor D and is expressed at high levels in adipose tissue. . Biol Chem 1992;267:9210-9213.
-
(1992)
J Biol Chem
, vol.267
, pp. 9210-9213
-
-
White, R.T.1
Damm, D.2
Hancock, N.3
-
222
-
-
0028296701
-
Concentrations of adipsin in blood and rates of adipsin secretion by adipose tissue in humans with normal, elevated and diminished adipose tissue mass
-
Napolitano A, Lowell BB, Damm D, et al. Concentrations of adipsin in blood and rates of adipsin secretion by adipose tissue in humans with normal, elevated and diminished adipose tissue mass. Int J Obes Relat Metab Disord 1994; 18:213-218.
-
(1994)
Int J Obes Relat Metab Disord
, vol.18
, pp. 213-218
-
-
Napolitano, A.1
Lowell, B.B.2
Damm, D.3
-
223
-
-
0032783129
-
The complement system: a pathway linking host defence and adipocyte biology
-
Esterbauer H, Krempler F, Oberkofler H, et al. The complement system: a pathway linking host defence and adipocyte biology. Eur J Clin Invest 1999; 29:653-656.
-
(1999)
Eur J Clin Invest
, vol.29
, pp. 653-656
-
-
Esterbauer, H.1
Krempler, F.2
Oberkofler, H.3
-
225
-
-
0027283572
-
The adipsin-acylation stimulating protein system and regulation of intracellular triglyceride synthesis
-
Baldo A, Sniderman AD, St-Luce S, et al. The adipsin-acylation stimulating protein system and regulation of intracellular triglyceride synthesis. . Clin Invest 1993;92:1543-1547.
-
(1993)
J Clin Invest
, vol.92
, pp. 1543-1547
-
-
Baldo, A.1
Sniderman, A.D.2
St-Luce, S.3
-
226
-
-
0033579513
-
Acylation stimulating protein (ASP) deficiency alters postprandial and adipose tissue metabolism in male mice
-
Murray I, Sniderman AD, Havel PJ, et al. Acylation stimulating protein (ASP) deficiency alters postprandial and adipose tissue metabolism in male mice. . Biol Chem 1999;274:36219-36225.
-
(1999)
J Biol Chem
, vol.274
, pp. 36219-36225
-
-
Murray, I.1
Sniderman, A.D.2
Havel, P.J.3
-
227
-
-
0028787490
-
Anovel serum protein similar to C1q, produced exclusively in adipocytes
-
Scherer P, Williams S, Fogliano M, et al. Anovel serum protein similar to C1q, produced exclusively in adipocytes. . Biol Chem 1995;270:26746-26749.
-
(1995)
J Biol Chem
, vol.270
, pp. 26746-26749
-
-
Scherer, P.1
Williams, S.2
Fogliano, M.3
-
228
-
-
17544382289
-
AdipoQ is a novel adipose-specific gene dysregulated in obesity
-
Hu E, Liang P, Spiegelman BM. AdipoQ is a novel adipose-specific gene dysregulated in obesity. . Biol Chem 1996;271:10697-10703.
-
(1996)
J Biol Chem
, vol.271
, pp. 10697-10703
-
-
Hu, E.1
Liang, P.2
Spiegelman, B.M.3
-
229
-
-
0029836585
-
Isolation and characterization of GBP28, a novel gelatin-binding protein purified from human plasma
-
(Tokyo)
-
Nakano Y, Tobe T, Choi-Miura NH, et al. Isolation and characterization of GBP28, a novel gelatin-binding protein purified from human plasma. . Biochem (Tokyo) 1996;120:803-812.
-
(1996)
J Biochem
, vol.120
, pp. 803-812
-
-
Nakano, Y.1
Tobe, T.2
Choi-Miura, N.H.3
-
230
-
-
0033515761
-
Paradoxical decrease of an adipose-specific protein, adiponectin, in obesity
-
Arita Y, Kihara S, Ouchi N, et al. Paradoxical decrease of an adipose-specific protein, adiponectin, in obesity. Biochem Biophys Res Commun 1999;257:79-83.
-
(1999)
Biochem Biophys Res Commun
, vol.257
, pp. 79-83
-
-
Arita, Y.1
Kihara, S.2
Ouchi, N.3
-
231
-
-
0029980285
-
cDNA cloning and expression of a novel adipose specific collagen-like factor, apM1 (AdiPose most abundant gene transcript 1)
-
Maeda K, Okubo K, Shimomura I, et al. cDNA cloning and expression of a novel adipose specific collagen-like factor, apM1 (AdiPose most abundant gene transcript 1). Biochem Biophys Res Commun 1996;221:286-289.
-
(1996)
Biochem Biophys Res Commun
, vol.221
, pp. 286-289
-
-
Maeda, K.1
Okubo, K.2
Shimomura, I.3
-
232
-
-
0032510463
-
The crystal structure of a complement-1q family protein suggests an evolutionary link to tumor necrosis factor
-
Shapiro L, Scherer PE. The crystal structure of a complement-1q family protein suggests an evolutionary link to tumor necrosis factor. Curr Biol 1998;8:335-338.
-
(1998)
Curr Biol
, vol.8
, pp. 335-338
-
-
Shapiro, L.1
Scherer, P.E.2
-
233
-
-
0036511213
-
ACRP30/adiponectin: an adipokine regulating glucose and lipid metabolism
-
Berg AH, Combs TP, Scherer PE. ACRP30/adiponectin: an adipokine regulating glucose and lipid metabolism. Trends Endocrinol Metab 2002;13:84-89.
-
(2002)
Trends Endocrinol Metab
, vol.13
, pp. 84-89
-
-
Berg, A.H.1
Combs, T.P.2
Scherer, P.E.3
-
234
-
-
0035852760
-
Proteolytic cleavage product of 30-kDa adipocyte complement-related protein increases fatty acid oxidation in muscle and causes weight loss in mice
-
Fruebis J, Tsao TS, Javorschi S, et al. Proteolytic cleavage product of 30-kDa adipocyte complement-related protein increases fatty acid oxidation in muscle and causes weight loss in mice. Proc Natl Acad Sci U S A 2001;98:2005-2010.
-
(2001)
Proc Natl Acad Sci U S A
, vol.98
, pp. 2005-2010
-
-
Fruebis, J.1
Tsao, T.S.2
Javorschi, S.3
-
235
-
-
0035663963
-
Endogenous glucose production is inhibited by the adipose-derived protein Acrp30
-
Combs TP, Berg AH, Obici S, et al. Endogenous glucose production is inhibited by the adipose-derived protein Acrp30. . Clin Invest 2001;108:1875-1881.
-
(2001)
J Clin Invest
, vol.108
, pp. 1875-1881
-
-
Combs, T.P.1
Berg, A.H.2
Obici, S.3
-
236
-
-
0036851817
-
Adiponectin stimulates glucose utilization and fatty-acid oxidation by activating AMP-activated protein kinase
-
Yamauchi T, Kamon J, Minokoshi Y, et al. Adiponectin stimulates glucose utilization and fatty-acid oxidation by activating AMP-activated protein kinase. Nat Med 2002;8:1288-1295.
-
(2002)
Nat Med
, vol.8
, pp. 1288-1295
-
-
Yamauchi, T.1
Kamon, J.2
Minokoshi, Y.3
-
237
-
-
0037135523
-
Disruption of adiponectin causes insulin resistance and neointimal formation
-
Kubota N, Terauchi Y, Yamauchi T, et al. Disruption of adiponectin causes insulin resistance and neointimal formation. . Biol Chem 2002;277:25863-25866.
-
(2002)
J Biol Chem
, vol.277
, pp. 25863-25866
-
-
Kubota, N.1
Terauchi, Y.2
Yamauchi, T.3
-
238
-
-
0036063777
-
Diet-induced insulin resistance in mice lacing adiponectin/ACRP30
-
Maeda N, Shimomura I, Kishida K, et al. Diet-induced insulin resistance in mice lacing adiponectin/ACRP30. Nat Med 2002;8:731-737.
-
(2002)
Nat Med
, vol.8
, pp. 731-737
-
-
Maeda, N.1
Shimomura, I.2
Kishida, K.3
-
239
-
-
0034891684
-
Weight reduction increases plasma levels of an adipose-derived anti-inflammatory protein, adiponectin
-
Yang WS, Lee WJ, Funahashi T, et al. Weight reduction increases plasma levels of an adipose-derived anti-inflammatory protein, adiponectin. . Clin Endocrinol Metab 2001;86:3815-3819.
-
(2001)
J Clin Endocrinol Metab
, vol.86
, pp. 3815-3819
-
-
Yang, W.S.1
Lee, W.J.2
Funahashi, T.3
-
240
-
-
0034999667
-
Hypoadiponectinemia in obesity and type 2 diabetes: close association with insulin resistance and hyperinsulinemia
-
Weyer C, Funahashi T, Tanaka S, et al. Hypoadiponectinemia in obesity and type 2 diabetes: close association with insulin resistance and hyperinsulinemia. . Clin Endocrinol Metab 2001;86:1930-1935.
-
(2001)
J Clin Endocrinol Metab
, vol.86
, pp. 1930-1935
-
-
Weyer, C.1
Funahashi, T.2
Tanaka, S.3
-
241
-
-
0035039227
-
Circulating concentrations of the adipocyte protein adiponectin are decreased in parallel with reduced insulin sensitivity during the progression to type 2 diabetes in rhesus monkeys
-
Hotta K, Funahashi T, Bodkin NL, et al. Circulating concentrations of the adipocyte protein adiponectin are decreased in parallel with reduced insulin sensitivity during the progression to type 2 diabetes in rhesus monkeys. Diabetes 2001;50:1126-1133.
-
(2001)
Diabetes
, vol.50
, pp. 1126-1133
-
-
Hotta, K.1
Funahashi, T.2
Bodkin, N.L.3
-
242
-
-
0035957040
-
Adipocyte-derived plasma protein, adiponectin, suppresses lipid accumulation and class A scavenger receptor expression in human monocyte-derived macrophages
-
Ouchi N, Kihara S, Arita Y, et al. Adipocyte-derived plasma protein, adiponectin, suppresses lipid accumulation and class A scavenger receptor expression in human monocyte-derived macrophages. Circulation 2001;103: 1057-1063.
-
(2001)
Circulation
, vol.103
, pp. 1057-1063
-
-
Ouchi, N.1
Kihara, S.2
Arita, Y.3
-
243
-
-
0034641647
-
Adiponectin, an adipocyte-derived plasma protein, inhibits endothelial NF-kappaB signaling through a cAMP-dependent pathway
-
Ouchi N, Kihara S, Arita Y, et al. Adiponectin, an adipocyte-derived plasma protein, inhibits endothelial NF-kappaB signaling through a cAMP-dependent pathway. Circulation 2000;102:1296-1301.
-
(2000)
Circulation
, vol.102
, pp. 1296-1301
-
-
Ouchi, N.1
Kihara, S.2
Arita, Y.3
-
244
-
-
0034096988
-
Plasma concentrations of a novel, adipose-specific protein, adiponectin, in type 2 diabetic patients
-
Hotta K, Funahashi T, Arita Y, et al. Plasma concentrations of a novel, adipose-specific protein, adiponectin, in type 2 diabetic patients. Arterioscler Thromb Vasc Biol 2000;20:1595-1599.
-
(2000)
Arterioscler Thromb Vasc Biol
, vol.20
, pp. 1595-1599
-
-
Hotta, K.1
Funahashi, T.2
Arita, Y.3
-
245
-
-
11144355637
-
Complex distribution, not absolute amount of adiponectin, correlates with thiazolidinedione-mediated improvement in insulin sensitivity
-
Pajvani UB, Hawkins M, Combs TP, et al. Complex distribution, not absolute amount of adiponectin, correlates with thiazolidinedione-mediated improvement in insulin sensitivity. . Biol Chem 2004;279:12152-12162.
-
(2004)
J Biol Chem
, vol.279
, pp. 12152-12162
-
-
Pajvani, U.B.1
Hawkins, M.2
Combs, T.P.3
-
246
-
-
0037494960
-
Cloning of adiponectin receptors that mediate antidiabetic metabolic effects
-
Yamauchi T, Kamon J, Ito Y, et al. Cloning of adiponectin receptors that mediate antidiabetic metabolic effects. Nature 2003;423:762-769.
-
(2003)
Nature
, vol.423
, pp. 762-769
-
-
Yamauchi, T.1
Kamon, J.2
Ito, Y.3
-
247
-
-
3142761477
-
T-cadherin is a receptor for hexameric and high-molecular-weight forms of Acrp30/adiponectin
-
Hug C, Wang J, Ahmad NS, et al. T-cadherin is a receptor for hexameric and high-molecular-weight forms of Acrp30/adiponectin. Proc Natl Acad Sci U S A 2004;101:10308-10313.
-
(2004)
Proc Natl Acad Sci U S A
, vol.101
, pp. 10308-10313
-
-
Hug, C.1
Wang, J.2
Ahmad, N.S.3
-
248
-
-
0023681544
-
Location and regulation of rat angiotensinogen messenger RNA
-
Cassis LA, Saye J, Peach MJ. Location and regulation of rat angiotensinogen messenger RNA. Hypertension 1988;11:591-596.
-
(1988)
Hypertension
, vol.11
, pp. 591-596
-
-
Cassis, L.A.1
Saye, J.2
Peach, M.J.3
-
249
-
-
0033026451
-
Co-expression of renin-angiotensin system genes in human adipose tissue
-
Engeli S, Gorzelniak K, Kreutz R, et al. Co-expression of renin-angiotensin system genes in human adipose tissue. . Hypertens 1999;17:555-560.
-
(1999)
J Hypertens
, vol.17
, pp. 555-560
-
-
Engeli, S.1
Gorzelniak, K.2
Kreutz, R.3
-
250
-
-
0031733280
-
Human adipose tissue expresses angiotensinogen and enzymes required for its conversion to angiotensin. II
-
Karlsson C, Lindell K, Ottosson M, et al. Human adipose tissue expresses angiotensinogen and enzymes required for its conversion to angiotensin. II. . Clin Endocrinol Metab 1998;83:3925-3929.
-
(1998)
J Clin Endocrinol Metab
, vol.83
, pp. 3925-3929
-
-
Karlsson, C.1
Lindell, K.2
Ottosson, M.3
-
251
-
-
0026740639
-
Tissue-specific nutritional regulation of angiotensinogen in adipose tissue
-
Frederich RC Jr, Kahn BB, Peach MJ, et al. Tissue-specific nutritional regulation of angiotensinogen in adipose tissue. Hypertension 1992;19:339-344.
-
(1992)
Hypertension
, vol.19
, pp. 339-344
-
-
Frederich, R.C.1
Kahn, B.B.2
Peach, M.J.3
-
252
-
-
0024591167
-
Angiotensinogen gene expression in 3T3-L1 cells
-
Saye JA, Cassis LA, Sturgill TW, et al. Angiotensinogen gene expression in 3T3-L1 cells. Am J Physiol 1989;256:C448-451.
-
(1989)
Am J Physiol
, vol.256
, pp. C448-C451
-
-
Saye, J.A.1
Cassis, L.A.2
Sturgill, T.W.3
-
253
-
-
0025299376
-
Changes in angiotensinogen messenger RNA in differentiating 3T3-F442A adipocytes
-
Saye J, Lynch KR, Peach MJ. Changes in angiotensinogen messenger RNA in differentiating 3T3-F442A adipocytes. Hypertension 1990;15:867-871.
-
(1990)
Hypertension
, vol.15
, pp. 867-871
-
-
Saye, J.1
Lynch, K.R.2
Peach, M.J.3
-
254
-
-
0031045605
-
Regulation by fatty acids of angiotensinogen gene expression in preadipose cells
-
Safonova I, Aubert J, Negrel R, et al. Regulation by fatty acids of angiotensinogen gene expression in preadipose cells. Biochem J 1997;322: 235-239.
-
(1997)
Biochem J
, vol.322
, pp. 235-239
-
-
Safonova, I.1
Aubert, J.2
Negrel, R.3
-
255
-
-
17944364171
-
Angiotensinogen-deficient mice exhibit impairment of diet-induced weight gain with alteration in adipose tissue development and increased locomotor activity
-
Massiera F, Seydoux J, Geloen A, et al. Angiotensinogen-deficient mice exhibit impairment of diet-induced weight gain with alteration in adipose tissue development and increased locomotor activity. Endocrinology 2001;142:5220-5225.
-
(2001)
Endocrinology
, vol.142
, pp. 5220-5225
-
-
Massiera, F.1
Seydoux, J.2
Geloen, A.3
-
256
-
-
0035650575
-
Adipose angiotensinogen is involved in adipose tissue growth and blood pressure regulation
-
Massiera F, Bloch-Faure M, Ceiler D, et al. Adipose angiotensinogen is involved in adipose tissue growth and blood pressure regulation. FASEB J 2001;15:2727-2729.
-
(2001)
FASEB J
, vol.15
, pp. 2727-2729
-
-
Massiera, F.1
Bloch-Faure, M.2
Ceiler, D.3
-
257
-
-
85047693986
-
Transgenic amplification of glucocorticoid action in adipose tissue causes high blood pressure in lmice
-
Masuzaki H, Yamamoto H, Kenyon CJ, et al. Transgenic amplification of glucocorticoid action in adipose tissue causes high blood pressure in lmice. . Clin Invest 2003;112:83-90.
-
(2003)
J Clin Invest
, vol.112
, pp. 83-90
-
-
Masuzaki, H.1
Yamamoto, H.2
Kenyon, C.J.3
-
258
-
-
0035905758
-
The hormone resistin links obesity to diabetes
-
Steppan CM, Bailey ST, Bhat S, et al. The hormone resistin links obesity to diabetes. Nature 2001;409:307-312.
-
(2001)
Nature
, vol.409
, pp. 307-312
-
-
Steppan, C.M.1
Bailey, S.T.2
Bhat, S.3
-
259
-
-
0034254655
-
FIZZ1, a novel cysteine-rich secreted protein associated with pulmonary inflammation, defines a new gene family
-
Holcomb IN, Kabakoff RC, Chan B, et al. FIZZ1, a novel cysteine-rich secreted protein associated with pulmonary inflammation, defines a new gene family. EMBO J 2000;19:4046-4055.
-
(2000)
EMBO J
, vol.19
, pp. 4046-4055
-
-
Holcomb, I.N.1
Kabakoff, R.C.2
Chan, B.3
-
261
-
-
0035815608
-
A cysteine-rich adipose tissue-specific secretory factor inhibits adipocyte differentiation
-
Kim KH, Lee K, Moon YS, et al. A cysteine-rich adipose tissue-specific secretory factor inhibits adipocyte differentiation. . Biol Chem 2001;276: 11252-11256.
-
(2001)
J Biol Chem
, vol.276
, pp. 11252-11256
-
-
Kim, K.H.1
Lee, K.2
Moon, Y.S.3
-
262
-
-
0242641149
-
Adipose tissue resistin expression is severely suppressed in obesity and stimulated by peroxisome proliferatoractivated receptor gamma agonists
-
Way JM, Gorgun CZ, Tong Q, et al. Adipose tissue resistin expression is severely suppressed in obesity and stimulated by peroxisome proliferatoractivated receptor gamma agonists. . Biol Chem 2001;276:25651-25653.
-
(2001)
J Biol Chem
, vol.276
, pp. 25651-25653
-
-
Way, J.M.1
Gorgun, C.Z.2
Tong, Q.3
-
263
-
-
0036090282
-
Increased resistin gene and protein expression in human abdominal adipose tissue
-
McTernan PG, McTernan CL, Chetty R, et al. Increased resistin gene and protein expression in human abdominal adipose tissue. . Clin Endocrinol Metab 2002;87:2407-2410.
-
(2002)
J Clin Endocrinol Metab
, vol.87
, pp. 2407-2410
-
-
McTernan, P.G.1
McTernan, C.L.2
Chetty, R.3
-
264
-
-
0035487109
-
Resistin/Fizz3 expression in relation to obesity and peroxisome proliferator-activated receptor-gamma action in humans
-
Savage DB, Sewter CP, Klenk ES, et al. Resistin/Fizz3 expression in relation to obesity and peroxisome proliferator-activated receptor-gamma action in humans. Diabetes 2001;50:2199-2202.
-
(2001)
Diabetes
, vol.50
, pp. 2199-2202
-
-
Savage, D.B.1
Sewter, C.P.2
Klenk, E.S.3
-
265
-
-
2442707674
-
Disulfide-dependent multimeric assembly of resistin family hormones
-
Patel SD, Rajala MW, Rossetti L, et al. Disulfide-dependent multimeric assembly of resistin family hormones. Science 2004;304:1154-1158.
-
(2004)
Science
, vol.304
, pp. 1154-1158
-
-
Patel, S.D.1
Rajala, M.W.2
Rossetti, L.3
-
266
-
-
4043085036
-
Adenovirus-mediated chronic "hyperresistinemia" leads to in vivo insuln resistance in normal rats
-
Satoh H, Nguyen MT, Miles PD, et al. Adenovirus-mediated chronic "hyperresistinemia" leads to in vivo insuln resistance in normal rats. . Clin Invest 2004;114:224-231.
-
(2004)
J Clin Invest
, vol.114
, pp. 224-231
-
-
Satoh, H.1
Nguyen, M.T.2
Miles, P.D.3
-
267
-
-
10744225368
-
Regulation of fasted blood glucose by resistin
-
Banerjee RR, Rangwala SM, Shapiro JS, et al. Regulation of fasted blood glucose by resistin. Science 2004;303:1195-1198.
-
(2004)
Science
, vol.303
, pp. 1195-1198
-
-
Banerjee, R.R.1
Rangwala, S.M.2
Shapiro, J.S.3
-
268
-
-
4043082182
-
Role of resistin in diet-induced hepatic insulin resistance
-
Muse ED, Obici S, Bhanot S, et al. Role of resistin in diet-induced hepatic insulin resistance. . Clin Invest 2004;114:232-239.
-
(2004)
J Clin Invest
, vol.114
, pp. 232-239
-
-
Muse, E.D.1
Obici, S.2
Bhanot, S.3
-
269
-
-
3042784523
-
Regulation of resistin expression and circulating levels in obesity, diabetes, and fasting
-
Rajala MW, Qi Y, Patel HR, et al. Regulation of resistin expression and circulating levels in obesity, diabetes, and fasting. Diabetes 2004;53:1671-1679.
-
(2004)
Diabetes
, vol.53
, pp. 1671-1679
-
-
Rajala, M.W.1
Qi, Y.2
Patel, H.R.3
-
270
-
-
0035487109
-
Resistin/Fizz3 expression in relation to obesity and peroxisome proliferator-activated receptor-gamma action in humans
-
Savage DB, Sewter CP, Klenk ES, et al. Resistin/Fizz3 expression in relation to obesity and peroxisome proliferator-activated receptor-gamma action in humans. Diabetes 2001;50:2199-2202.
-
(2001)
Diabetes
, vol.50
, pp. 2199-2202
-
-
Savage, D.B.1
Sewter, C.P.2
Klenk, E.S.3
-
271
-
-
1842506529
-
The current biology of resistin
-
Steppan CM, Lazar MA. The current biology of resistin. . Intern Med 2004; 255:439-447.
-
(2004)
J Intern Med
, vol.255
, pp. 439-447
-
-
Steppan, C.M.1
Lazar, M.A.2
|