Physiological consequences of β-adrenergic receptor disruption

Journal of Molecular Medicine

Volumn 76, Issue 11, 1998, Pages 764-772

  Rohrer, Daniel K ^a,b,c,d  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b Department of Molecular Pharmacology

^c STANFORD UNIVERSITY   (United States)

^d ROCHE BIOSCIENCE   (United States)

Author keywords

Adrenergic; Knockout; Transgenic

Indexed keywords

ADENYLATE CYCLASE; BETA 1 ADRENERGIC RECEPTOR; BETA 2 ADRENERGIC RECEPTOR; BETA 3 ADRENERGIC RECEPTOR; PROTEIN KINASE;

ADRENERGIC SYSTEM; BETA ADRENERGIC STIMULATION; BLOOD VESSEL TONE; BROWN ADIPOSE TISSUE; CARBOHYDRATE METABOLISM; CARDIOVASCULAR FUNCTION; CHRONOTROPISM; GENE OVEREXPRESSION; HEART PERFORMANCE; INOTROPISM; LIPID METABOLISM; NONHUMAN; REVIEW; TRANSGENIC ANIMAL; WHITE ADIPOSE TISSUE;

ANIMALS; GENE EXPRESSION; HUMANS; MICE; MICE, KNOCKOUT; RECEPTORS, ADRENERGIC, BETA;

EID: 0031686860     PISSN: 09462716     EISSN: None     Source Type: Journal    
DOI: 10.1007/s001090050278     Document Type: Review

References (72)

1. Ahlquist RP (1948) A study of the adrenotropic receptors. Am J Physiol 153:586-600
2. Lands AM, Luduena FP, Buzzo HJ (1967) Differentiation of receptors responsive to isoproterenol. Life Sci 6:2241-2249
3. Lands AM, Arnold A, McAuliff JP, Luduena FP, Brown TJ (1967) Differentiation of receptor systems activated by sympathomimetic amines. Nature 214:597-598
4. Harms HH, Zaagsma J, et al (1977) Differentiation of beta-adrenoceptors in right atrium, diaphragm and adipose tissue of the rat, using stereoisomers of propranolol, alprenolol, nifenalol and practolol. Life Sci 21:123-128
5. Arch JR, Ainsworth AT, Cawthorne MA, Piercy V, Sennitt MV, Thody VE, Wilson C, Wilson S (1984) Atypical beta-adrenoceptor on brown adipocytes as target for anti-obesity drugs. Nature 309:163-165
6. Brodele OE (1991) Beta 1- and beta 2-adrenoceptors in the human heart: properties, function, and alterations in chronic heart failure. Pharmacol Rev 43:203-242 (published erratum appears in 43:350)
7. Ruffolo RJ, Hieble JP (1994) Alpha-adrenoceptors. Pharmacol Ther 61:1-64
8. Lafontan M (1994) Differential recruitment and differential regulation by physiological amines of fat cell beta-1, beta-2 and beta-3 adrenergic receptors expressed in native fat cells and in transfected cell lines. Cell Signal 6:363-392
9. Strosberg AD (1997) Structure and function of the beta 3-adrenergic receptor. Annu Rev Pharmacol Toxicol 37:421-150
10. Van Waarde A, Meeder JG, Blanksma PK, Brodde OE, Visser GM, Elsinga PH, Paans AM, Vaalburg W, Lie KI (1992) Uptake of radioligands by rat heart and lung in vivo: CGP 12177 does and CGP 26505 does not reflect binding to beta-adrenoceptors. Eur J Pharmacol 222:107-112
11. Frielle T, Collins S, Daniel KW, Caron MG, Lefkowitz RJ, Kobilka BK (1987) Cloning of the cDNA for the human beta 1-adrenergic receptor. Proc Natl Acad Sci USA 84:7920-7924
12. Dixon RA, Kobilka BK, Strader DJ, Benovic JL, Dohlman HG, Frielle T, Bolanowski MA, Bennett CD, Rands E, Diehl RE, et al (1986) Cloning of the gene and cDNA for mammalian beta-adrenergic receptor and homology with rhodopsin. Nature 321:75-79
13. Emorine LJ, Marullo S, Briend SM, Patey G, Tate K, Delavier KC, Strosberg AD (1989) Molecular characterization of the human beta 3-adrenergic receptor. Science 245:1118-1121
14. Strader CD, Fong TM, Graziano MP, Tota MR (1995) The family of G-protein-coupled receptors. FASEB J 9:745-954
15. Xiao RP, Ji X, Lakatta EG (1995) Functional coupling of the beta 2-adrenoceptor to a pertussis toxin-sensitive G protein in cardiac myocytes. Mol Pharmacol 47:322-329
16. Gauthier C, Tavernier G, Charpentier F, Langin D, Le MH (1996) Functional beta3-adrenoceptor in the human heart. J Clin Invest 98:556-562
17. Wei LN (1997) Transgenic animals as new approaches in pharmacological studies. Annu Rev Pharmacol Toxicol 37:119-141
18. Milano CA, Allen LF, Rockman HA, Dolber PC, McMinn TR, Chien KR, Johnson TD, Bond RA, Lefkowitz RJ (1994) Enhanced myocardial function in transgenic mice overexpressing the beta 2-adrenergic receptor. Science 264:582-586
19. Bertin B, Mansier P, Makeh I, Briand P, Rostene W, Swynghedauw B, Strosberg AD (1993) Specific atrial overexpression of G protein coupled human beta 1 adrenoceptors in transgenic mice. Cardiovasc Res 27:1606-1612
20. Grujic D, Susulic VS, Harper ME, Himms HJ, Cunningham BA, Corkey BE, Lowell BB (1997) Beta3-adrenergic receptors on white and brown adipocytes mediate beta3-selective agonist-induced effects on energy expenditure, insulin secretion, and food intake. A study usina transgenic and gene knockout mice. J Biol Chem 272:17686-17693
21. Susulic VS, Frederich RC, Lawitts J, Tozzo E, Kahn BB, Harper ME, Himms HJ, Flier JS, Lowell BB (1995) Targeted disruption of the beta 3-adrenergic receptor gene. J Biol Chem 270:29483-29492
22. Rohrer DK, Desai KH, Jasper JR, Stevens ME, Regula DJ, Barsh GS, Bernstein D, Kobilka BK (1996) Targeted disruption of the mouse beta1-adrenergic receptor gene: developmental and cardiovascular effects. Proc Natl Acad Sci USA 93:7375-7380
23. Revelli JP, Preitner F, Samec S, Muniesa P, Kuehne F, Boss O, Vassalli JD, Dulloo A, Seydoux J, Giacobino JP, Huarte J, Ody C (1997) Targeted gene disruption reveals a leptin-independent role for the mouse beta3-adrenoceptor in the regulation of body composition. J Clin Invest 100:1098-1106
24. Koch WJ, Rockman HA, Samama P, Hamilton RA, Bond RA, Milano CA, Lefkowitz RJ (1995) Cardiac function in mice overexpressing the beta-adrenergic receptor kinase or a beta ARK inhibitor. Science 268:1350-1353
25. Murphree SS and Saffitz JE (1988) Delineation of the distribution of beta-adrenergic receptor subtypes in canine myocardium. Circ Res 63:117-125
26. Muntz KH, Zhao M, Miller JC (1994) Downregulation of myocardial beta-adrenergic receptors. Receptor subtype selectivity. Circ Res 74:369-375
27. Kaumann AJ (1986) The beta 1-adrenoceptor antagonist CGP 20712 A unmasks beta 2-adrenoceptors activated by (-)-adrenaline in rat sinoatrial node. Naunyn Schmiedebergs Arch Pharmacol 332:406-409
28. Kaumann AJ and Lemoine H (1987) Beta 2-adrenoceptor-mediated positive inotropic effect of adrenaline in human ventricular myocardium. Quantitative discrepancies with binding and adenylate cyclase stimulation. Naunyn Schmiedebergs Arch Pharmacol 335:403-411
29. Takei M, Furukawa Y, Narita M, Murakami M, Ren LM, Karasawa Y, Chiba S (1992) Sympathetic nerve stimulation activates both beta 1- and beta 2-adrenoceptors of SA and AV nodes in anesthetized dog hearts. Jpn J Pharmacol 59:23-30
30. Hall JA, Petch MC, Brown MJ (1989) Intracoronary injections of salbutamol demonstrate the presence of functional beta 2-adrenoceptors in the human heart. Circ Res 65:546-553
31. Juberg EN, Minneman KP, Abel PW (1985) Beta 1- and beta 2-adrenoceptor binding and functional response in right and left atria of rat heart. Naunyn Schmiedebergs Arch Pharmacol 330:193-202
32. Piercy V (1988) Method for assessing the activity of drugs at beta 1- and beta 2-adrenoceptors in the same animal. J Pharmacol Toxicol Methods 20:125-133
33. Zhou QY, Quaife CJ, Palmiter RD (1995) Targeted disruption of the tyrosine hydroxylase gene reveals that catecholamines are required for mouse fetal development. Nature 374:640-643
34. Thomas SA, Matsumoto AM, Palmiter RD (1995) Noradrenaline is essential for mouse fetal development. Nature 374:643-646
35. Threadgill DW, Dlugosz AA, Hansen LA, Tennenbaum T, Lichti U, Yee D, LaMantia C, Mourton T, Herrup K, Harris RC, et al (1995) Targeted disruption of mouse EGF receptor: effect of genetic background on mutant phenotype. Science 269:230-234
36. Sibilia M and Wagner EF (1995) Strain-dependent epithelial defects in mice lacking the EGF receptor. Science 269:234-238 (published erratum appears in 269:909)
37. Bonyadi M, Rusholme SA, Cousins FM, Su HC, Biron CA, Farrall M, Akhurst RJ (1997) Mapping of a major genetic moditier of embryonic lethality in TGF beta 1 knockout mice. Nat Genet 15:207-211
38. Pavan WJ, Mac S, Cheng M, Tilghman SM (1995) Quantitative trait loci that modify the severity of spotting in piebald mice. Genome Res 5:29-41
39. MacPhee M, Chepenik KP, Liddell RA, Nelson KK, Siracusa LD, Buchberg AM (1995) The secretory phospholipase A2 gene is a candidate for the Mom1 locus, a major modifier of ApcMin-induced intestinal neoplasia. Cell 81:957-966
40. Bristow MR, Hershberger RE, Port JD, Minobe W, Rasmussen R (1989) Beta 1- and beta 2-adrenergic receptor-mediated adenylate cyclase stimulation in nonfailing and failing human ventricular myocardium. Mol Pharmacol 35:295-303
41. Green SA, Holt BD, Liggett SB (1992) Beta 1- and beta 2-adrenergic receptors display subtype-selective coupling to Gs. Mol Pharmacol 41:889-893
42. Levy FO, Zhu X, Kaumann AJ, Birnhaumer L (1993) Efficacy of beta 1-adrenergic receptors is lower than that of beta 2-adrenergic receptors. Proc Natl Acad Sci USA 90:10798-10802
43. Rohrer DK, Schauble EH, Desai KH, Kobilka BK, Bernstein D (1998) Alterations in dynamic heart rate control in the beta-1 adrenergic receptor knockout mouse. Am J Physiol 274:H1184-1193
44. Desai KH, Rohrer DK, Kobilka BK, Bernstein D (1996) Diminished contractile response to isoproterenol in beta-1 adrenergic receptor deficient mice (abstract). Circulation 94 [Suppl 1]:1288
45. Bond RA, Leff P, Johnson TD, Milano CA, Rockman HA, McMinn TR, Apparsundaram S, Hyek MF, Kenakin TP, Allen LF, et al (1995) Physiological effects of inverse agonists in transgenic mice with myocardial overexpression of the beta 2-adrenoceptor. Nature 374:272-276
46. Christensen G, Wang Y, Chien KR (1997) physiological assesment of complex cardiac phenotypes in genetically engineered mice. Am J Physiol 272:H2513-2524
47. Kendall MJ and Rajman I (1994) A risk-benefit assessment of celiprolol in the treatment of cardiovascular disease. Drug Saf 10:220-232
48. Gilbert EM, Abraham WT, Olsen S, Hauler B, White M, Mealy P, Larrabee P, Bristow MR (1996) Comparative hemodynamic, left ventricular functional, and antiadrenergic effects of chronic treatment with metoprolol versus carvedilol in the failing heart. Circulation 94:2817-2825
49. Heidenreich PA, Lee TT, Massie BM (1997) Effect of beta-blockade on mortality in patients with heart failure: a meta-analysis of randomized clinical trials. J Am Coll Cardiol 30:27-34
50. Kaumann AJ and Molenaar P (1997) Modulation of human cardiac function through 4 beta-adrenoceptor populations. Naunyn-Schmeidebergs Arch Pharmacol 355:667-681
51. Walston J, Silver K, Bogardus C, Knowler WC, Celi HS, Austin S, Manning B, Strosberg AD, Stern MP, Raben N, et al (1995) Time of onset of non-insulin-dependent diabetes mellitus and genetic variation in the beta 3-adrenergic-receptor gene. N Engl J Med 333:343-347
52. Clement K, Vaisse C, Manning BS, Basdevant A, Guy GB, Ruiz J, Silver KD, Shuldiner AR, Froguel P, Strosberg AD (1995) Genetic variation in the beta 3-adrenergic receptor and an increased capacity to gain weight in patients with morbid obesity. N Engl J Med 333:352-354
53. Kadowaki H, Yasuda K, Iwamoto K, Otabe S, Shimokawa K, Silver K, Walston J, Yoshinaga H, Kosaka K, Yamada N, et al (1995) A mutation in the beta 3-adrenergic receptor gene is associated with obesity and hyperinsulinemia in Japanese subjects. Biochem Biophys Res Commun 215:555-560
54. Yuan X, Yamada K, Koyama K, Ichikawa F, Ishiyama S, Koyanagi A, Koyama W, Nonaka K (1997) Beta 3-adrenergic receptor gene polymorphism is not a major genetic determinant of obesity and diabetes in Japanese general population. Diabetes Res Clin Pract 37:1-7
55. Rissamen J, Kuopusjarvi J, Pihlajamaki J, Sipilainen R, Heikkinen S, Vanhala M, Kekalainen P, Kuusisto J, Laakso M (1997) The Trp64Arg polymorphism of the beta 3-Adrenergic receptor gene. Lack of association with NIDDM and features of insulin resistance syndrome. Diabetes Care 20:1319-1323
56. Collins S, Daniel KW, Rohlfs EM, Ramkumar V, Taylor IL, Gettys TW (1994) Impaired expression and functional activity of the beta 3- and beta 1-adrenergic receptors in adipose tissue of congenitally obese (C57BL/6 J ob/ob) mice. Mol Endocrinol 8:518-527
57. Gerlai R (1996) Gene-targeting studies of mammalian behavior: is it the mutation or the background genotype? Trends Neurosci 19:177-181
58. Xu M, Moratalla R, Gold LH, Hiroi N, Koob GF, Graybiel AM, Tonegawa S (1994) Dopamine D1 receptor mutant mice arc deficient in striatal expression of dynorphin and in dopamine-mediated behavioral responses. Cell 79:729-742
59. Drago J, Gerfen CR, Lachowicz JE, Steiner H, Hollon TR, Love PE, Ooi GT, Grinberg A, Lee EJ, Huang SP, et al (1994) Altered striatal function in a mutant mouse lacking D1 A dopamine receptors. Proc Natl Acad Sci USA 91:12564-12568
60. Aiba A, Chen C, Herrup K, Rosenmund C, Stevens CF, Tonegawa S (1994) Reduced hippocampal long-term potentiation and context-specific deficit in associative learning in mGluR1 mutant mice. Cell 79:365-375
61. Conquet F, Bashir ZI, Davies CH, Daniel H, Ferraguti F, Bordi F, Franz BK, Reggiani A, Matarese V, Conde F, et al (1994) Motor deficit and impairment of synaptic plasticity in mice lacking mGluR1. Nature 372:237-243
62. Mantzoros CS, Qu D, Frederich RC, Susulic VS, Lowell BB, Maratos FE, Flier JS (1996) Activation of beta(3) adrenergic receptors suppresses leptin expression and mediates a leptin-independent inhibition of food intake in mice. Diabetes 45:909-414
63. Muzzin P, Revelli JP, Kuhne F, Gocayne JD, McCombie WR, Venter JC, Giacobino JP, Fraser CM (1991) An adipose tissue-specific beta-adrenergic receptor. Molecular cloning and down-regulation in obesity. J Biol Chem 266:24053-24058
64. Mansier P, Medigue C, Charlotte N, Vermeiren C, Corabocuf E, Deroubai E, Ratner E, Chevalier B, Clairambault J, Carre F, Dahkli T, Berlin B, Briand P, Strosberg D, Swyngliedauw B (1996) Decreased heart rate variability in transgenic mice overexpressing atrial beta 1-adrenoceptors. Am J Physiol 270:H1465-1472
65. Choi D, Koch WJ, Hunter JJ, Rockman HA (1997) Mechanism of beta-adrenergic receptor desensitization in cardiac hypertrophy is increased beta-adrenergic receptor kinase. J Biol Chem 272:17223-17229
66. Green SA, Cole G, Jacinto M, Innis M, Liggett SB (1993) A polymorphism of the human beta 2-adrenergic receptor within the fourth transmembrane domain alters ligand binding and functional properties of the receptor. J Biol Chem 268:23116-23121
67. Hasty P, Ramirez SR, Krumlauf R, Bradley A (1991) Introduction of a subtle mutation into the Hox-2.6 locus in embryonic stem cells. Nature 350:243-246 (published erratum appears in 353:94)
68. Hanks M, Wurst W, Anson CL, Auerbach AB, Joyner AL (1995) Rescue of the En-1 mutant phenotype by replacement of En-1 with En-2. Science 269:679-682
69. MacMillan LB, Hein L, Smith MS, Piascik MT, Limbird LE (1996) Central hypotensive effects of the alpha2a-adrenergic receptor subtype. Science 273:801-803
70. Wang Y, Schnegelsberg PN, Dausman J, Jaenisch R (1996) Functional redundancy of the muscle-specific transcription factors Myf5 and myogenin. Nature 379:823-825
71. Turki J, Lorenz JN, Green SA, Donnelly ET, Jacinto M, Liggett SB (1996) Myocardial signaling defects and impaired cardiac function of a human beta 2-adrenergic receptor polymorphism expressed in transgenic mice. Proc Natl Acad Sci USA 93:10483-10488
72. Eason MG, Kurose H, Holt BD, Raymond JR, Liggett SB (1992) Simultaneous coupling of alpha 2-adrenergic receptors to two G-proteins with opposing effects. Subtype-selective coupling of alpha 2C10, alpha 2C4, and alpha 2C2 adrenergic receptors to Gi and Gs. J Biol Chem 267:15795-15801